{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:35Z","timestamp":1791308855515,"version":"4.3.1"},"publisher-location":"Berlin, Heidelberg","reference-count":264,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642335693","type":"print"},{"value":"9783642335709","type":"electronic"}],"license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-3-642-33570-9_11","type":"book-chapter","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T12:31:22Z","timestamp":1355401882000},"page":"219-255","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Complexity of Botulinum Neurotoxins: Challenges for Detection Technology"],"prefix":"10.1007","author":[{"given":"Martin B.","family":"Dorner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Melanie","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skadi","family":"Kull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte G.","family":"Dorner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,14]]},"reference":[{"key":"11_CR1","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1039\/b718587c","volume":"133","author":"M Adler","year":"2008","unstructured":"Adler M, Wacker R, Niemeyer CM (2008) Sensitivity by combination: immuno-PCR and related technologies. Analyst 133:702\u2013718","journal-title":"Analyst"},{"key":"11_CR2","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1089\/fpd.2004.1.247","volume":"1","author":"D Akbulut","year":"2004","unstructured":"Akbulut D, Grant KA, McLauchlin J (2004) Development and application of real-time PCR assays to detect fragments of the Clostridium botulinum types A, B, and E neurotoxin genes for investigation of human foodborne and infant botulism. Foodborne Pathog Dis 1:247\u2013257","journal-title":"Foodborne Pathog Dis"},{"key":"11_CR3","doi-asserted-by":"publisher","first-page":"4526","DOI":"10.1111\/j.1742-4658.2011.08113.x","volume":"278","author":"K Aktories","year":"2011","unstructured":"Aktories K, Lang AE, Schwan C et al (2011) Actin as target for modification by bacterial protein toxins. FEBS J 278:4526\u20134543","journal-title":"FEBS J"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.bios.2008.03.045","volume":"24","author":"GP Anderson","year":"2008","unstructured":"Anderson GP, Taitt CR (2008) Amplification of microsphere-based microarrays using catalyzed reporter deposition. Biosens Bioelectron 24:324\u2013328","journal-title":"Biosens Bioelectron"},{"key":"11_CR5","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1006\/abio.2001.5028","volume":"291","author":"C Anne","year":"2001","unstructured":"Anne C, Cornille F, Lenoir C et al (2001) High-throughput fluorogenic assay for determination of botulinum type B neurotoxin protease activity. Anal Biochem 291:253\u2013261","journal-title":"Anal Biochem"},{"key":"11_CR6","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.vetmic.2011.07.018","volume":"154","author":"F Anniballi","year":"2012","unstructured":"Anniballi F, Auricchio B, Delibato E et al (2012) Multiplex real-time PCR SYBR green for detection and typing of group III Clostridium botulinum. Vet Microbiol 154:332\u2013338","journal-title":"Vet Microbiol"},{"key":"11_CR260","doi-asserted-by":"publisher","unstructured":"Ahnert-Hilger G, M\u00fcnster-Wandowski A, H\u00f6ltje M (2012) Synaptic vesicle proteins: Targets and routes for Botulinum nurotoxins. doi:10.1007\/978-3-642-33570-9-8","DOI":"10.1007\/978-3-642-33570-9-8"},{"key":"11_CR7","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/S0041-0101(01)00101-5","volume":"39","author":"KR Aoki","year":"2001","unstructured":"Aoki KR (2001) A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice. Toxicon 39:1815\u20131820","journal-title":"Toxicon"},{"key":"11_CR8","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1046\/j.1472-765X.1997.00204.x","volume":"25","author":"E Aranda","year":"1997","unstructured":"Aranda E, Rodriguez MM, Asensio MA et al (1997) Detection of Clostridium botulinum types A, B, E and F in foods by PCR and DNA probe. Lett Appl Microbiol 25:186\u2013190","journal-title":"Lett Appl Microbiol"},{"key":"11_CR9","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1001\/jama.285.8.1059","volume":"285","author":"SS Arnon","year":"2001","unstructured":"Arnon SS, Schechter R, Inglesby TV et al (2001) Botulinum toxin as a biological weapon: medical and public health management. J Am Med Assoc 285:1059\u20131070","journal-title":"J Am Med Assoc"},{"key":"11_CR10","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1128\/JCM.01192-07","volume":"45","author":"I Artin","year":"2007","unstructured":"Artin I, Bjorkman P, Cronqvist J et al (2007) First case of type E wound botulism diagnosed using real-time PCR. J Clin Microbiol 45:3589\u20133594","journal-title":"J Clin Microbiol"},{"key":"11_CR11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jim.2007.06.003","volume":"325","author":"O Attr\u00e9e","year":"2007","unstructured":"Attr\u00e9e O, Guglielmo-Viret V, Gros V et al (2007) Development and comparison of two immunoassay formats for rapid detection of botulinum neurotoxin type A. J Immunol Methods 325:78\u201387","journal-title":"J Immunol Methods"},{"key":"11_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-61779-102-4_3","volume":"739","author":"K Bagramyan","year":"2011","unstructured":"Bagramyan K, Kalkum M (2011) Ultrasensitive detection of botulinum neurotoxins and anthrax lethal factor in biological samples by ALISSA. Methods Mol Biol 739:23\u201336","journal-title":"Methods Mol Biol"},{"key":"11_CR13","doi-asserted-by":"publisher","first-page":"e2041","DOI":"10.1371\/journal.pone.0002041","volume":"3","author":"K Bagramyan","year":"2008","unstructured":"Bagramyan K, Barash JR, Arnon SS et al (2008) Attomolar detection of botulinum toxin type A in complex biological matrices. PLoS ONE 3:e2041","journal-title":"PLoS ONE"},{"key":"11_CR14","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1039\/c0lc00431f","volume":"11","author":"J Balsam","year":"2011","unstructured":"Balsam J, Ossandon M, Kostov Y et al (2011) Lensless CCD-based fluorometer using a micromachined optical S\u00f6ller collimator. Lab Chip 11:941\u2013949","journal-title":"Lab Chip"},{"key":"11_CR15","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.3201\/eid1110.041279","volume":"11","author":"JR Barr","year":"2005","unstructured":"Barr JR, Moura H, Boyer AE et al (2005) Botulinum neurotoxin detection and differentiation by mass spectrometry. Emerg Infect Dis 11:1578\u20131583","journal-title":"Emerg Infect Dis"},{"key":"11_CR16","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.2307\/4576062","volume":"36","author":"I Bengtson","year":"1921","unstructured":"Bengtson I (1921) Direct inoculation test for B. botulinus toxin. Public Health Rep 36:1665\u20131671","journal-title":"Public Health Rep"},{"key":"11_CR17","doi-asserted-by":"publisher","first-page":"164","DOI":"10.2307\/4576258","volume":"37","author":"I Bengtson","year":"1922","unstructured":"Bengtson I (1922) Preliminary note on a toxin-producing anaerobe isolated from the larvae of Lucilia caesar. Public Health Rep 37:164\u2013170","journal-title":"Public Health Rep"},{"key":"11_CR261","doi-asserted-by":"publisher","unstructured":"Bercsenyi k, Giribaldi F, Schiavo G (2012) The elusive compass of clostridial Neurotoxins: Deciding when and where to go. doi:10.1007\/978-3-642-33570-9-5","DOI":"10.1007\/978-3-642-33570-9-5"},{"key":"11_CR18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/aem.38.2.297-300.1979","volume":"38","author":"MJ Betley","year":"1979","unstructured":"Betley MJ, Sugiyama H (1979) Noncorrelation between mouse toxicity and serologically assayed toxin in Clostridium botulinum type A culture fluids. Appl Environ Microbiol 38:297\u2013300","journal-title":"Appl Environ Microbiol"},{"key":"11_CR262","doi-asserted-by":"publisher","unstructured":"Binz T (2012) Clostridial Neurotoxin light chains:Devices for SNARE cleavage Mediated blockde of neurotransmission. doi:10.1007\/978-3-642-33570-9-7","DOI":"10.1007\/978-3-642-33570-9-7"},{"key":"11_CR19","doi-asserted-by":"publisher","first-page":"3916","DOI":"10.1021\/ac050485f","volume":"77","author":"AE Boyer","year":"2005","unstructured":"Boyer AE, Moura H, Woolfitt AR et al (2005) From the mouse to the mass spectrometer: detection and differentiation of the endoproteinase activities of botulinum neurotoxins A\u2013G by mass spectrometry. Anal Chem 77:3916\u20133924","journal-title":"Anal Chem"},{"key":"11_CR20","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.3390\/molecules16032391","volume":"16","author":"AE Boyer","year":"2011","unstructured":"Boyer AE, Gallegos-Candela M, Lins RC et al (2011) Quantitative mass spectrometry for bacterial protein toxins\u2014a sensitive, specific, high-throughput tool for detection and diagnosis. Molecules 16:2391\u20132413","journal-title":"Molecules"},{"key":"11_CR21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4315\/0362-028X-64.2.201","volume":"64","author":"A Braconnier","year":"2001","unstructured":"Braconnier A, Broussolle V, Perelle S et al (2001) Screening for Clostridium botulinum type A, B, and E in cooked chilled foods containing vegetables and raw material using polymerase chain reaction and molecular probes. J Food Prot 64:201\u2013207","journal-title":"J Food Prot"},{"key":"11_CR22","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/nature03123","volume":"432","author":"MA Breidenbach","year":"2004","unstructured":"Breidenbach MA, Brunger AT (2004) Substrate recognition strategy for botulinum neurotoxin serotype A. Nature 432:925\u2013929","journal-title":"Nature"},{"key":"11_CR23","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.vetmic.2009.12.030","volume":"144","author":"CE Brooks","year":"2010","unstructured":"Brooks CE, Clarke HJ, Finlay DA et al (2010) Culture enrichment assists the diagnosis of cattle botulism by a monoclonal antibody based sandwich ELISA. Vet Microbiol 144:226\u2013230","journal-title":"Vet Microbiol"},{"key":"11_CR24","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.toxicon.2008.12.027","volume":"54","author":"AT Brunger","year":"2009","unstructured":"Brunger AT, Rummel A (2009) Receptor and substrate interactions of clostridial neurotoxins. Toxicon 54:550\u2013560","journal-title":"Toxicon"},{"key":"11_CR25","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1007\/s00018-008-8088-0","volume":"65","author":"AT Brunger","year":"2008","unstructured":"Brunger AT, Jin R, Breidenbach MA (2008) Highly specific interactions between botulinum neurotoxins and synaptic vesicle proteins. Cell Mol Life Sci 65:2296\u20132306","journal-title":"Cell Mol Life Sci"},{"key":"11_CR26","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1128\/AEM.03059-09","volume":"76","author":"J Brunt","year":"2010","unstructured":"Brunt J, Webb MD, Peck MW (2010) Rapid affinity immunochromatography column-based tests for sensitive detection of Clostridium botulinum neurotoxins and Escherichia coli O157. Appl Environ Microbiol 76:4143\u20134150","journal-title":"Appl Environ Microbiol"},{"key":"11_CR27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1113\/jphysiol.1949.sp004364","volume":"109","author":"ASV Burgen","year":"1949","unstructured":"Burgen ASV, Dickens F, Zatman LJ (1949) The action of botulinum toxin on the neuro-muscular junction. J Physiol 109:10\u201324","journal-title":"J Physiol"},{"key":"11_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.toxicon.2003.10.013","volume":"43","author":"H-Y Chao","year":"2004","unstructured":"Chao H-Y, Wang Y-C, Tang S-S et al (2004) A highly sensitive immuno-polymerase chain reaction assay for Clostridium botulinum neurotoxin type A. Toxicon 43:27\u201334","journal-title":"Toxicon"},{"key":"11_CR29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jchromb.2004.05.033","volume":"809","author":"DJ Chiao","year":"2004","unstructured":"Chiao DJ, Shyu RH, Hu CS et al (2004) Colloidal gold-based immunochromatographic assay for detection of botulinum neurotoxin type B. J Chromatogr B Analyt Technol Biomed Life Sci 809:37\u201341","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"11_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1089\/hyb.2007.0550","volume":"27","author":"DJ Chiao","year":"2008","unstructured":"Chiao DJ, Wey JJ, Shyu RH et al (2008a) Monoclonal antibody-based lateral flow assay for detection of botulinum neurotoxin type A. Hybridoma (Larchmt) 27:31\u201335","journal-title":"Hybridoma (Larchmt)"},{"key":"11_CR31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1089\/hyb.2007.0529","volume":"27","author":"DJ Chiao","year":"2008","unstructured":"Chiao DJ, Wey JJ, Tang SS (2008b) Monoclonal antibody-based enzyme immunoassay for detection of botulinum neurotoxin type A. Hybridoma (Larchmt) 27:43\u201347","journal-title":"Hybridoma (Larchmt)"},{"key":"11_CR32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1046\/j.1365-2672.1997.00313.x","volume":"84","author":"MD Collins","year":"1998","unstructured":"Collins MD, East AK (1998) Phylogeny and taxonomy of the food-borne pathogen Clostridium botulinum and its neurotoxins. J Appl Microbiol 84:5\u201317","journal-title":"J Appl Microbiol"},{"key":"11_CR33","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/jaoac\/85.5.1025","volume":"85","author":"KE Craven","year":"2002","unstructured":"Craven KE, Ferreira JL, Harrison MA et al (2002) Specific detection of Clostridium botulinum types A, B, E, and F using the polymerase chain reaction. J AOAC Int 85:1025\u20131028","journal-title":"J AOAC Int"},{"key":"11_CR34","doi-asserted-by":"publisher","first-page":"6457","DOI":"10.1128\/AEM.00805-09","volume":"75","author":"D De Medici","year":"2009","unstructured":"De Medici D, Anniballi F, Wyatt GM et al (2009) Multiplex PCR to detect botulinum neurotoxin-producing clostridia in clinical, food and environmental samples. Appl Environ Microbiol 75:6457\u20136461","journal-title":"Appl Environ Microbiol"},{"key":"11_CR35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/jcm.20.3.379-383.1984","volume":"20","author":"M Dezfulian","year":"1984","unstructured":"Dezfulian M, Hatheway CL, Yolken RH et al (1984) Enzyme-linked immunosorbent assay for detection of Clostridium botulinum type A and type B toxins in stool samples of infants with botulism. J Clin Microbiol 20:379\u2013383","journal-title":"J Clin Microbiol"},{"key":"11_CR36","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1128\/jcm.31.9.2402-2409.1993","volume":"31","author":"GJ Doellgast","year":"1993","unstructured":"Doellgast GJ, Triscott MX, Beard GA et al (1993) Sensitive enzyme-linked immunosorbent assay for detection of Clostridium botulinum neurotoxins A, B, and E using signal amplification via enzyme-linked coagulation assay. J Clin Microbiol 31:2402\u20132409","journal-title":"J Clin Microbiol"},{"key":"11_CR37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/jcm.32.1.105-111.1994","volume":"32","author":"GJ Doellgast","year":"1994","unstructured":"Doellgast GJ, Beard GA, Bottoms JD et al (1994) Enzyme-linked immunosorbent assay and enzyme-linked coagulation assay for detection of Clostridium botulinum neurotoxins A, B, and E and solution-phase complexes with dual-label antibodies. J Clin Microbiol 32:105\u2013111","journal-title":"J Clin Microbiol"},{"key":"11_CR38","doi-asserted-by":"publisher","first-page":"14701","DOI":"10.1073\/pnas.0404107101","volume":"101","author":"M Dong","year":"2004","unstructured":"Dong M, Tepp WH, Johnson EA et al (2004) Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells. Proc Natl Acad Sci U S A 101:14701\u201314706","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0022-1759(02)00498-2","volume":"274","author":"BG Dorner","year":"2003","unstructured":"Dorner BG, Steinbach S, H\u00fcser MB et al (2003) Single-cell analysis of the murine chemokines MIP-1alpha, MIP-1beta, RANTES and ATAC\/lymphotactin by flow cytometry. J Immunol Methods 274:83\u201391","journal-title":"J Immunol Methods"},{"key":"11_CR40","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1002\/mds.20625","volume":"20","author":"D Dressler","year":"2005","unstructured":"Dressler D, Lange M, Bigalke H (2005) Mouse diaphragm assay for detection of antibodies against botulinum toxin type B. Mov Disord 20:1617\u20131619","journal-title":"Mov Disord"},{"key":"11_CR41","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF01575751","volume":"29","author":"AK East","year":"1994","unstructured":"East AK, Collins MD (1994) Conserved structure of genes encoding components of botulinum neurotoxin complex M and the sequence of the gene coding for the nontoxic component in nonproteolytic Clostridium botulinum type F. Curr Microbiol 29:69\u201377","journal-title":"Curr Microbiol"},{"key":"11_CR42","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0022-1759(94)00313-L","volume":"180","author":"TAN Ekong","year":"1995","unstructured":"Ekong TAN, McLellan K, Sesardic D (1995) Immunological detection of Clostridium botulinum toxin type A in therapeutic preparations. J Immunol Methods 180:181\u2013191","journal-title":"J Immunol Methods"},{"key":"11_CR43","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1111\/j.1365-2672.2009.04325.x","volume":"107","author":"ER Evans","year":"2009","unstructured":"Evans ER, Skipper PJ, Shone CC (2009) An assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin. J Appl Microbiol 107:1384\u20131391","journal-title":"J Appl Microbiol"},{"key":"11_CR44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1128\/aem.61.1.389-392.1995","volume":"61","author":"P Fach","year":"1995","unstructured":"Fach P, Gibert M, Griffais R et al (1995) PCR and gene probe identification of botulinum neurotoxin A-, B-, E-, F-, and G-producing Clostridium spp. and evaluation in food samples. Appl Environ Microbiol 61:389\u2013392","journal-title":"Appl Environ Microbiol"},{"key":"11_CR45","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1365-2672.2009.04215.x","volume":"107","author":"P Fach","year":"2009","unstructured":"Fach P, Micheau P, Mazuet C et al (2009) Development of real-time PCR tests for detecting botulinum neurotoxins A, B, E, F producing Clostridium botulinum, Clostridium baratii and Clostridium butyricum. J Appl Microbiol 107:465\u2013473","journal-title":"J Appl Microbiol"},{"key":"11_CR46","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1016\/j.ijfoodmicro.2010.04.006","volume":"145","author":"P Fach","year":"2011","unstructured":"Fach P, Fenicia L, Knutsson R et al (2011) An innovative molecular detection tool for tracking and tracing Clostridium botulinum types A, B, E, F and other botulinum neurotoxin producing Clostridia based on the GeneDisc cycler. Int J Food Microbiol 145:S145\u2013S151","journal-title":"Int J Food Microbiol"},{"key":"11_CR47","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1128\/AEM.02234-06","volume":"73","author":"L Fenicia","year":"2007","unstructured":"Fenicia L, Anniballi F, De MD et al (2007) SYBR green real-time PCR method to detect Clostridium botulinum type A. Appl Environ Microbiol 73:2891\u20132896","journal-title":"Appl Environ Microbiol"},{"key":"11_CR48","doi-asserted-by":"publisher","first-page":"S152","DOI":"10.1016\/j.ijfoodmicro.2011.02.001","volume":"145","author":"L Fenicia","year":"2011","unstructured":"Fenicia L, Fach P, van Rotterdam BJ et al (2011) Towards an international standard for detection and typing botulinum neurotoxin-producing Clostridia types A, B, E and F in food, feed and environmental samples: a European ring trial study to evaluate a real-time PCR assay. Int J Food Microbiol 145:S152\u2013S157","journal-title":"Int J Food Microbiol"},{"key":"11_CR49","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ab.2010.11.045","volume":"410","author":"G Ferracci","year":"2011","unstructured":"Ferracci G, Marconi S, Mazuet C et al (2011) A label-free biosensor assay for botulinum neurotoxin B in food and human serum. Anal Biochem 410:281\u2013288","journal-title":"Anal Biochem"},{"key":"11_CR50","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/jaoac\/84.1.85","volume":"84","author":"JL Ferreira","year":"2001","unstructured":"Ferreira JL (2001) Comparison of amplified ELISA and mouse bioassay procedures for determination of botulinal toxins A, B, E, and F. J AOAC Int 84:85\u201388","journal-title":"J AOAC Int"},{"key":"11_CR51","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0890-8508(87)90015-6","volume":"1","author":"JL Ferreira","year":"1987","unstructured":"Ferreira JL, Hamdy MK, Herd ZL et al (1987) Monoclonal antibody for the detection of Clostridium botulinum type A toxin. Mol Cell Probes 1:337\u2013345","journal-title":"Mol Cell Probes"},{"key":"11_CR52","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1128\/aem.56.3.808-811.1990","volume":"56","author":"JL Ferreira","year":"1990","unstructured":"Ferreira JL, Hamdy MK, McCay SG et al (1990) Monoclonal antibody to type F Clostridium botulinum toxin. Appl Environ Microbiol 56:808\u2013811","journal-title":"Appl Environ Microbiol"},{"key":"11_CR53","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/jaoac\/84.5.1460","volume":"84","author":"JL Ferreira","year":"2001","unstructured":"Ferreira JL, Eliasberg SJ, Harrison MA et al (2001) Detection of preformed type A botulinal toxin in hash brown potatoes by using the mouse bioasssay and a modified ELISA test. J AOAC Int 84:1460\u20131464","journal-title":"J AOAC Int"},{"key":"11_CR54","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/jaoac\/86.2.314","volume":"86","author":"JL Ferreira","year":"2003","unstructured":"Ferreira JL, Maslanka S, Johnson E et al (2003) Detection of botulinal neurotoxins A, B, E, and F by amplified enzyme-linked immunosorbent assay: collaborative study. J AOAC Int 86:314\u2013331","journal-title":"J AOAC Int"},{"key":"11_CR55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4315\/0362-028X-67.1.203","volume":"67","author":"JL Ferreira","year":"2004","unstructured":"Ferreira JL, Eliasberg SJ, Edmonds P et al (2004) Comparison of the mouse bioassay and enzyme-linked immunosorbent assay procedures for the detection of type A botulinal toxin in food. J Food Prot 67:203\u2013206","journal-title":"J Food Prot"},{"key":"11_CR263","doi-asserted-by":"publisher","unstructured":"Fischer A (2012) Synchronized Chapterone function of Botulinum neurotoxin domain Mediates light chain translocation into neutrons.doi:10.1007\/978-3-642-33570-9-6","DOI":"10.1007\/978-3-642-33570-9-6"},{"key":"11_CR56","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/andp.19484370105","volume":"437","author":"T F\u00f6rster","year":"1948","unstructured":"F\u00f6rster T (1948) Zwischenmolekulare Energiewanderung und Fluoreszenz. Ann Phys 437:55\u201375","journal-title":"Ann Phys"},{"key":"11_CR57","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1128\/jcm.32.8.1911-1917.1994","volume":"32","author":"G Franciosa","year":"1994","unstructured":"Franciosa G, Ferreira JL, Hatheway CL (1994) Detection of type A, B, and E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR: evidence of unexpressed type B toxin genes in type A toxigenic organisms. J Clin Microbiol 32:1911\u20131917","journal-title":"J Clin Microbiol"},{"key":"11_CR58","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1128\/jcm.34.4.882-885.1996","volume":"34","author":"G Franciosa","year":"1996","unstructured":"Franciosa G, Fenicia L, Caldiani C et al (1996) PCR for detection of Clostridium botulinum type C in avian and environmental samples. J Clin Microbiol 34:882\u2013885","journal-title":"J Clin Microbiol"},{"key":"11_CR59","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/jb\/mvj161","volume":"140","author":"Y Fujinaga","year":"2006","unstructured":"Fujinaga Y (2006) Transport of bacterial toxins into target cells: pathways followed by cholera toxin and botulinum progenitor toxin. J Biochem 140:155\u2013160","journal-title":"J Biochem"},{"key":"11_CR60","doi-asserted-by":"publisher","first-page":"974943","DOI":"10.1155\/2010\/974943","volume":"2010","author":"Y Fujinaga","year":"2010","unstructured":"Fujinaga Y (2010) Interaction of botulinum toxin with the epithelial barrier. J Biomed Biotechnol 2010:974943","journal-title":"J Biomed Biotechnol"},{"key":"11_CR61","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1006\/bbrc.1994.2805","volume":"205","author":"Y Fujinaga","year":"1994","unstructured":"Fujinaga Y, Inoue K, Shimazaki S et al (1994) Molecular construction of Clostridium botulinum type C progenitor toxin and its gene organization. Biochem Biophys Res Commun 205:1291\u20131298","journal-title":"Biochem Biophys Res Commun"},{"key":"11_CR62","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.toxicon.2008.11.014","volume":"54","author":"Y Fujinaga","year":"2009","unstructured":"Fujinaga Y, Matsumura T, Jin Y et al (2009) A novel function of botulinum toxin-associated proteins: HA proteins disrupt intestinal epithelial barrier to increase toxin absorption. Toxicon 54:583\u2013586","journal-title":"Toxicon"},{"key":"11_CR264","doi-asserted-by":"publisher","unstructured":"Fujinaga Y, Sugawara Y,Mtsumura T (2012) Uptake of Botulinum Neurotoxin in the intestine.doi: 10.1007\/978-3-642-33570-9-3","DOI":"10.1007\/978-3-642-33570-9-3"},{"key":"11_CR63","doi-asserted-by":"publisher","first-page":"5432","DOI":"10.2741\/3091","volume":"13","author":"R Ganapathy","year":"2008","unstructured":"Ganapathy R, Padmanabhan S, Eric YP et al (2008) Rapid detection of botulinum neurotoxins A, B, E, and F by optical immunoassay. Front Biosci 13:5432\u20135440","journal-title":"Front Biosci"},{"key":"11_CR64","doi-asserted-by":"publisher","first-page":"6600","DOI":"10.1021\/jf100789n","volume":"58","author":"EA Garber","year":"2010","unstructured":"Garber EA, Venkateswaran KV, O\u2019Brien TW (2010) Simultaneous multiplex detection and confirmation of the proteinaceous toxins abrin, ricin, botulinum toxins, and Staphylococcus enterotoxins A, B, and C in food. J Agric Food Chem 58:6600\u20136607","journal-title":"J Agric Food Chem"},{"key":"11_CR65","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1177\/104063870701900402","volume":"19","author":"PS Gaunt","year":"2007","unstructured":"Gaunt PS, Kalb SR, Barr JR (2007) Detection of botulinum type E toxin in channel catfish with visceral toxicosis syndrome using catfish bioassay and endopep mass spectrometry. J Vet Diagn Invest 19:349\u2013354","journal-title":"J Vet Diagn Invest"},{"key":"11_CR66","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.4315\/0362-028X-68.7.1477","volume":"68","author":"M Gauthier","year":"2005","unstructured":"Gauthier M, Cadieux B, Austin JW et al (2005) Cloth-based hybridization array system for the detection of Clostridium botulinum type A, B, E, and F neurotoxin genes. J Food Prot 68:1477\u20131483","journal-title":"J Food Prot"},{"key":"11_CR67","doi-asserted-by":"publisher","first-page":"7897","DOI":"10.1128\/AEM.71.12.7897-7903.2005","volume":"71","author":"F Gessler","year":"2005","unstructured":"Gessler F, Hampe K, B\u00f6hnel H (2005) Sensitive detection of botulinum neurotoxin types C and D with an immunoaffinity chromatographic column test. Appl Environ Microbiol 71:7897\u20137903","journal-title":"Appl Environ Microbiol"},{"key":"11_CR68","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.diagmicrobio.2006.04.014","volume":"56","author":"F Gessler","year":"2006","unstructured":"Gessler F, Hampe K, Schmidt M et al (2006) Immunomagnetic beads assay for the detection of botulinum neurotoxin types C and D. Diagn Microbiol Infect Dis 56:225\u2013232","journal-title":"Diagn Microbiol Infect Dis"},{"key":"11_CR69","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.diagmicrobio.2006.07.017","volume":"57","author":"F Gessler","year":"2007","unstructured":"Gessler F, Pagel-Wieder S, Avondet MA et al (2007) Evaluation of lateral flow assays for the detection of botulinum neurotoxin type A and their application in laboratory diagnosis of botulism. Diagn Microbiol Infect Dis 57:243\u2013249","journal-title":"Diagn Microbiol Infect Dis"},{"key":"11_CR70","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1365-2672.1987.tb04939.x","volume":"63","author":"AM Gibson","year":"1987","unstructured":"Gibson AM, Modi NK, Roberts TA et al (1987) Evaluation of a monoclonal antibody-based immunoassay for detecting type A Clostridium botulinum toxin produced in pure culture and an inoculated model cured meat system. J Appl Bacteriol 63:217\u2013226","journal-title":"J Appl Bacteriol"},{"key":"11_CR71","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-2672.1988.tb01873.x","volume":"64","author":"AM Gibson","year":"1988","unstructured":"Gibson AM, Modi NK, Roberts TA et al (1988) Evaluation of a monoclonal antibody-based immunoassay for detecting type B Clostridium botulinum toxin produced in pure culture and an inoculated model cured meat system. J Appl Bacteriol 64:285\u2013291","journal-title":"J Appl Bacteriol"},{"key":"11_CR72","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ab.2011.01.043","volume":"413","author":"MA Gilmore","year":"2011","unstructured":"Gilmore MA, Williams D, Okawa Y et al (2011) Depolarization after resonance energy transfer (DARET): a sensitive fluorescence-based assay for botulinum neurotoxin protease activity. Anal Biochem 413:36\u201342","journal-title":"Anal Biochem"},{"key":"11_CR73","unstructured":"Gim\u00e9nez DF, Cicarelli AS (1970) Studies on strain 84 of Clostridium botulinum. Zentralbl Bakteriol Parasitenkd Infektionskr Abt 1 Orig Reihe A 215:212\u2013220"},{"key":"11_CR74","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1039\/b900794f","volume":"134","author":"JW Grate","year":"2009","unstructured":"Grate JW, Warner MG, Ozanich RM Jr et al (2009) Renewable surface fluorescence sandwich immunoassay biosensor for rapid sensitive botulinum toxin detection in an automated fluidic format. Analyst 134:987\u2013996","journal-title":"Analyst"},{"key":"11_CR75","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1126\/science.1214270","volume":"335","author":"S Gu","year":"2012","unstructured":"Gu S, Rumpel S, Zhou J et al (2012) Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science 335:977\u2013981","journal-title":"Science"},{"key":"11_CR265","doi-asserted-by":"publisher","unstructured":"Gu S, Jin R (2012) Assembly and function of the Botulinum neurotoxin progenitor complex. doi: 10.1007\/978-3-642-33570-9-2","DOI":"10.1007\/978-3-642-33570-9-2"},{"key":"11_CR76","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jim.2005.04.003","volume":"301","author":"V Guglielmo-Viret","year":"2005","unstructured":"Guglielmo-Viret V, Attree O, Blanco-Gros V et al (2005) Comparison of electrochemiluminescence assay and ELISA for the detection of Clostridium botulinum type B neurotoxin. J Immunol Methods 301:164\u2013172","journal-title":"J Immunol Methods"},{"key":"11_CR77","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3181\/00379727-35-8938P","volume":"35","author":"JB Gunnison","year":"1936","unstructured":"Gunnison JB, Cummings JR, Meyer KF (1936) Clostridium botulinum Type E. Proc Soc Exp Biol Med 35:278\u2013280","journal-title":"Proc Soc Exp Biol Med"},{"key":"11_CR78","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/BF00500299","volume":"311","author":"E Habermann","year":"1980","unstructured":"Habermann E, Dreyer F, Bigalke H (1980) Tetanus toxin blocks the neuromuscular transmission in vitro like botulinum A toxin. Naunyn Schmiedebergs Arch Pharmacol 311:33\u201340","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"11_CR79","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/jcm.34.8.1934-1938.1996","volume":"34","author":"B Hallis","year":"1996","unstructured":"Hallis B, James BA, Shone CC (1996) Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activities. J Clin Microbiol 34:1934\u20131938","journal-title":"J Clin Microbiol"},{"key":"11_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2007.01.028","volume":"587","author":"SM Han","year":"2007","unstructured":"Han SM, Cho JH, Cho IH et al (2007) Plastic enzyme-linked immunosorbent assays (ELISA)-on-a-chip biosensor for botulinum neurotoxin A. Anal Chim Acta 587:1\u20138","journal-title":"Anal Chim Acta"},{"key":"11_CR81","doi-asserted-by":"publisher","first-page":"24777","DOI":"10.1074\/jbc.M703446200","volume":"282","author":"K Hasegawa","year":"2007","unstructured":"Hasegawa K, Watanabe T, Suzuki T et al (2007) A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms. J Biol Chem 282:24777\u201324783","journal-title":"J Biol Chem"},{"key":"11_CR82","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1128\/jcm.25.12.2334-2338.1987","volume":"25","author":"CL Hatheway","year":"1987","unstructured":"Hatheway CL, McCroskey LM (1987) Examination of feces and serum for diagnosis of infant botulism in 336 patients. J Clin Microbiol 25:2334\u20132338","journal-title":"J Clin Microbiol"},{"key":"11_CR83","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/infdis\/60.3.260","volume":"60","author":"EL Hazen","year":"1937","unstructured":"Hazen EL (1937) A strain of B. botulinus not classified as type A, B, or C. J Infect Dis 60:260\u2013264","journal-title":"J Infect Dis"},{"key":"11_CR84","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1099\/jmm.0.031179-0","volume":"60","author":"M Hedeland","year":"2011","unstructured":"Hedeland M, Moura H, Baverud V et al (2011) Confirmation of botulism in birds and cattle by the mouse bioassay and Endopep-MS. J Med Microbiol 60:1299\u20131305","journal-title":"J Med Microbiol"},{"key":"11_CR85","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1099\/jmm.0.46802-0","volume":"56","author":"A Heffron","year":"2007","unstructured":"Heffron A, Poxton IR (2007) A PCR approach to determine the distribution of toxin genes in closely related Clostridium species: Clostridium botulinum type C and D neurotoxins and C2 toxin, and Clostridium novyi \u03b1 toxin. J Med Microbiol 56:196\u2013201","journal-title":"J Med Microbiol"},{"key":"11_CR86","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1021\/bi801686b","volume":"48","author":"JS Henkel","year":"2009","unstructured":"Henkel JS, Jacobson M, Tepp W et al (2009) Catalytic properties of botulinum neurotoxin subtypes A3 and A4. Biochemistry 48:2522\u20132528","journal-title":"Biochemistry"},{"key":"11_CR87","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1128\/JB.01180-06","volume":"189","author":"KK Hill","year":"2007","unstructured":"Hill KK, Smith TJ, Helma CH et al (2007) Genetic diversity among botulinum neurotoxin-producing clostridial strains. J Bacteriol 189:818\u2013832","journal-title":"J Bacteriol"},{"key":"11_CR266","doi-asserted-by":"publisher","unstructured":"Hill KK, Smith TJ (2012) Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin Gene. Cluster and toxin subtypes. doi: 10.1007\/978-3-642-33570-9-1","DOI":"10.1007\/978-3-642-33570-9-1"},{"key":"11_CR88","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/1471-2180-10-267","volume":"10","author":"BJ Hill","year":"2010","unstructured":"Hill BJ, Skerry JC, Smith TJ et al (2010) Universal and specific quantitative detection of botulinum neurotoxin genes. BMC Microbiol 10:267","journal-title":"BMC Microbiol"},{"key":"11_CR89","doi-asserted-by":"publisher","first-page":"4478","DOI":"10.1128\/AEM.71.8.4478-4486.2005","volume":"71","author":"HB Hines","year":"2005","unstructured":"Hines HB, Lebeda F, Hale M et al (2005) Characterization of botulinum progenitor toxins by mass spectrometry. Appl Environ Microbiol 71:4478\u20134486","journal-title":"Appl Environ Microbiol"},{"key":"11_CR90","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/026119290803600205","volume":"36","author":"A Huber","year":"2008","unstructured":"Huber A, France RM, Riccalton-Banks L et al (2008) The intercostal NMJ assay: a new alternative to the conventional LD50 assay for the determination of the therapeutic potency of botulinum toxin preparations. Altern Lab Anim 36:141\u2013152","journal-title":"Altern Lab Anim"},{"key":"11_CR91","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1128\/iai.64.5.1589-1594.1996","volume":"64","author":"K Inoue","year":"1996","unstructured":"Inoue K, Fujinaga Y, Watanabe T et al (1996) Molecular composition of Clostridium botulinum type A progenitor toxins. Infect Immun 64:1589\u20131594","journal-title":"Infect Immun"},{"key":"11_CR92","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1749-6632.1994.tb17274.x","volume":"733","author":"R Jahn","year":"1994","unstructured":"Jahn R, Niemann H (1994) Molecular mechanisms of clostridial neurotoxins. Ann N Y Acad Sci 733:245\u2013255","journal-title":"Ann N Y Acad Sci"},{"key":"11_CR93","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0072-9752(07)01511-4","volume":"91","author":"EA Johnson","year":"2008","unstructured":"Johnson EA, Montecucco C (2008) Botulism. Handb Clin Neurol 91:333\u2013368","journal-title":"Handb Clin Neurol"},{"key":"11_CR94","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.toxicon.2006.05.007","volume":"48","author":"RG Jones","year":"2006","unstructured":"Jones RG, Alsop TA, Hull R et al (2006) Botulinum type A toxin neutralisation by specific IgG and its fragments: a comparison of mouse systemic toxicity and local flaccid paralysis assays. Toxicon 48:246\u2013254","journal-title":"Toxicon"},{"key":"11_CR95","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jim.2007.09.014","volume":"329","author":"RG Jones","year":"2008","unstructured":"Jones RG, Ochiai M, Liu Y et al (2008) Development of improved SNAP25 endopeptidase immuno-assays for botulinum type A and E toxins. J Immunol Methods 329:92\u2013101","journal-title":"J Immunol Methods"},{"key":"11_CR96","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jim.2009.01.001","volume":"343","author":"RG Jones","year":"2009","unstructured":"Jones RG, Liu Y, Sesardic D (2009) New highly specific botulinum type C1 endopeptidase immunoassays utilising SNAP25 or syntaxin substrates. J Immunol Methods 343:21\u201327","journal-title":"J Immunol Methods"},{"key":"11_CR97","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jpba.2010.08.013","volume":"54","author":"RG Jones","year":"2011","unstructured":"Jones RG, Liu Y, Halls C et al (2011) Release of proteolytic activity following reduction in therapeutic human serum albumin containing products: detection with a new neoepitope endopeptidase immunoassay. J Pharm Biomed Anal 54:74\u201380","journal-title":"J Pharm Biomed Anal"},{"key":"11_CR98","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.vascn.2011.11.002","volume":"65","author":"SG Joshi","year":"2012","unstructured":"Joshi SG (2012) Detection of biologically active botulinum neurotoxin-A in serum using high-throughput FRET-assay. J Pharmacol Toxicol Methods 65:8\u201312","journal-title":"J Pharmacol Toxicol Methods"},{"key":"11_CR99","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00210-010-0589-3","volume":"383","author":"I Just","year":"2011","unstructured":"Just I, Rohrbeck A, H\u00fclsenbeck SC et al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn Schmiedebergs Arch Pharmacol 383:247\u2013252","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"11_CR100","doi-asserted-by":"publisher","first-page":"6140","DOI":"10.1021\/ac0511748","volume":"77","author":"SR Kalb","year":"2005","unstructured":"Kalb SR, Goodnough MC, Malizio CJ et al (2005) Detection of botulinum neurotoxin A in a spiked milk sample with subtype identification through toxin proteomics. Anal Chem 77:6140\u20136146","journal-title":"Anal Chem"},{"key":"11_CR101","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ab.2006.01.027","volume":"351","author":"SR Kalb","year":"2006","unstructured":"Kalb SR, Moura H, Boyer AE et al (2006) The use of endopep-MS for the detection of botulinum toxins A, B, E, and F in serum and stool samples. Anal Biochem 351:84\u201392","journal-title":"Anal Biochem"},{"key":"11_CR102","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ijms.2008.04.004","volume":"278","author":"SR Kalb","year":"2008","unstructured":"Kalb SR, Smith TJ, Moura H et al (2008) The use of endopep-MS to detect multiple subtypes of botulinum neurotoxins A, B, E, and F. Int J Mass Spectrom 278:101\u2013108","journal-title":"Int J Mass Spectrom"},{"key":"11_CR103","doi-asserted-by":"publisher","first-page":"e5355","DOI":"10.1371\/journal.pone.0005355","volume":"4","author":"SR Kalb","year":"2009","unstructured":"Kalb SR, Lou J, Garcia-Rodriguez C et al (2009) Extraction and inhibition of enzymatic activity of botulinum neurotoxins\/A1,\/A2, and\/A3 by a panel of monoclonal anti-BoNT\/A antibodies. PLoS ONE 4:e5355","journal-title":"PLoS ONE"},{"key":"11_CR104","doi-asserted-by":"publisher","first-page":"e12237","DOI":"10.1371\/journal.pone.0012237","volume":"5","author":"SR Kalb","year":"2010","unstructured":"Kalb SR, Garcia-Rodriguez C, Lou J et al (2010) Extraction of BoNT\/A,\/B,\/E, and\/F with a single, high affinity monoclonal antibody for detection of botulinum neurotoxin by endopep-MS. PLoS ONE 5:e12237","journal-title":"PLoS ONE"},{"key":"11_CR105","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-90-481-9815-3_8","volume-title":"Detection of biological agents for the prevention of bioterrorism","author":"SR Kalb","year":"2011","unstructured":"Kalb SR, Pirkle JL, Barr JR (2011a) Mass spectrometric detection of botulinum neurotoxin by measuring its activity in serum and milk. In: Banoub J (ed) Detection of biological agents for the prevention of bioterrorism. Springer, Dordrecht, pp 115\u2013129"},{"key":"11_CR106","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1471-2091-12-58","volume":"12","author":"SR Kalb","year":"2011","unstructured":"Kalb SR, Santana WI, Geren IN et al (2011b) Extraction and inhibition of enzymatic activity of botulinum neurotoxins\/B1,\/B2,\/B3,\/B4, and\/B5 by a panel of monoclonal anti-BoNT\/B antibodies. BMC Biochem 12:58","journal-title":"BMC Biochem"},{"key":"11_CR107","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00216-012-5767-3","volume":"403","author":"SR Kalb","year":"2012","unstructured":"Kalb SR, Baudys J, Rees JC et al (2012a) De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics. Anal Bioanal Chem 403:215\u2013226","journal-title":"Anal Bioanal Chem"},{"key":"11_CR108","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.febslet.2011.11.033","volume":"586","author":"SR Kalb","year":"2012","unstructured":"Kalb SR, Baudys J, Webb RP et al (2012b) Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5. FEBS Lett 586:109\u2013115","journal-title":"FEBS Lett"},{"key":"11_CR109","first-page":"541","volume":"60","author":"DA Kautter","year":"1977","unstructured":"Kautter DA, Solomon HM (1977) Collaborative study of a method for the detection of Clostridium botulinum and its toxins in foods. J Assoc Off Anal Chem 60:541\u2013545","journal-title":"J Assoc Off Anal Chem"},{"key":"11_CR110","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0014-5793(99)00948-5","volume":"456","author":"JE Keller","year":"1999","unstructured":"Keller JE, Neale EA, Oyler G et al (1999a) Persistence of botulinum neurotoxin action in cultured spinal cord cells. FEBS Lett 456:137\u2013142","journal-title":"FEBS Lett"},{"key":"11_CR111","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1002\/(SICI)1099-1263(199912)19:1+<S13::AID-JAT607>3.0.CO;2-3","volume":"19","author":"JE Keller","year":"1999","unstructured":"Keller JE, Nowakowski JL, Filbert MG et al (1999b) Rapid microplate assay for monitoring botulinum neurotoxin B catalytic activity. J Appl Toxicol 19:S13\u2013S17","journal-title":"J Appl Toxicol"},{"key":"11_CR112","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1128\/AEM.67.1.206-216.2001","volume":"67","author":"B Kimura","year":"2001","unstructured":"Kimura B, Kawasaki S, Nakano H et al (2001) Rapid, quantitative PCR monitoring of growth of Clostridium botulinum type E in modified-atmosphere-packaged fish. Appl Environ Microbiol 67:206\u2013216","journal-title":"Appl Environ Microbiol"},{"key":"11_CR113","doi-asserted-by":"publisher","first-page":"4387","DOI":"10.1128\/AEM.02490-09","volume":"76","author":"S Kirchner","year":"2010","unstructured":"Kirchner S, Kr\u00e4mer KM, Schulze M et al (2010) Pentaplexed quantitative real-time PCR assay for the simultaneous detection and quantification of botulinum neurotoxin-producing clostridia in food and clinical samples. Appl Environ Microbiol 76:4387\u20134395","journal-title":"Appl Environ Microbiol"},{"key":"11_CR114","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.jchromb.2009.02.053","volume":"877","author":"B Klaubert","year":"2009","unstructured":"Klaubert B, Vujtovic-Ockenga N, Wermter R et al (2009) Determination of botulinum toxins after peptic sample pre-treatment by multidimensional nanoscale liquid chromatography and nano-electrospray ion-trap mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 877:1084\u20131092","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"11_CR115","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.snb.2005.07.007","volume":"113","author":"T Klewitz","year":"2006","unstructured":"Klewitz T, Gessler F, Beer H et al (2006) Immunochromatographic assay for determination of botulinum neurotoxin type D. Sens Actuators B Chem 113:582\u2013589","journal-title":"Sens Actuators B Chem"},{"key":"11_CR116","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/256495a0","volume":"256","author":"G K\u00f6hler","year":"1975","unstructured":"K\u00f6hler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495\u2013497","journal-title":"Nature"},{"key":"11_CR117","doi-asserted-by":"publisher","first-page":"e1355","DOI":"10.1542\/peds.2006-3386","volume":"120","author":"K K\u00f6nig","year":"2007","unstructured":"K\u00f6nig K, Ringe H, Dorner BG et al (2007) Atypical tetanus in a completely immunized 14-year-old boy. Pediatrics 120:e1355\u2013e1358","journal-title":"Pediatrics"},{"key":"11_CR118","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nsb879","volume":"10","author":"LK Koriazova","year":"2003","unstructured":"Koriazova LK, Montal M (2003) Translocation of botulinum neurotoxin light chain protease through the heavy chain channel. Nat Struct Biol 10:13\u201318","journal-title":"Nat Struct Biol"},{"key":"11_CR119","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/978-1-60327-567-5_14","volume":"503","author":"Y Kostov","year":"2009","unstructured":"Kostov Y, Sergeev N, Wilson S et al (2009) A simple portable electroluminescence illumination-based CCD detector. Methods Mol Biol 503:259\u2013272","journal-title":"Methods Mol Biol"},{"key":"11_CR120","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1128\/iai.18.3.761-766.1977","volume":"18","author":"S Kozaki","year":"1977","unstructured":"Kozaki S, Miyazaki S, Sakaguchi G (1977) Development of antitoxin with each of two complementary fragments of Clostridium botulinum type B derivative toxin. Infect Immun 18:761\u2013766","journal-title":"Infect Immun"},{"key":"11_CR121","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7883\/yoken1952.32.199","volume":"32","author":"S Kozaki","year":"1979","unstructured":"Kozaki S, Dufrenne J, Hagenaars AM et al (1979) Enzyme linked immunosorbent assay (ELISA) for detection of Clostridium botulinum type B toxin. Jpn J Med Sci Biol 32:199\u2013205","journal-title":"Jpn J Med Sci Biol"},{"key":"11_CR122","doi-asserted-by":"publisher","first-page":"2916","DOI":"10.1021\/ac902909r","volume":"82","author":"S Kull","year":"2010","unstructured":"Kull S, Pauly D, St\u00f6rmann B et al (2010) Multiplex detection of microbial and plant toxins by immunoaffinity enrichment and matrix-assisted laser desorption\/ionization mass spectrometry. Anal Chem 82:2916\u20132924","journal-title":"Anal Chem"},{"key":"11_CR123","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0956-5663(94)80015-4","volume":"9","author":"P Kumar","year":"1994","unstructured":"Kumar P, Colston JT, Chambers JP et al (1994) Detection of botulinum toxin using an evanescent wave immunosensor. Biosens Bioelectron 9:57\u201363","journal-title":"Biosens Bioelectron"},{"key":"11_CR124","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.snb.2007.07.140","volume":"130","author":"J Ladd","year":"2008","unstructured":"Ladd J, Taylor AD, Homola J et al (2008) Detection of botulinum neurotoxins in buffer and honey using a surface plasmon resonance (SPR) sensor. Sens Actuators B Chem 130:129\u2013134","journal-title":"Sens Actuators B Chem"},{"key":"11_CR125","first-page":"449","volume":"14","author":"G Landmann","year":"1904","unstructured":"Landmann G (1904) Ueber die Ursache der Darmst\u00e4dter Bohnenvergiftung. Hyg Rundsch 14:449\u2013452","journal-title":"Hyg Rundsch"},{"key":"11_CR126","first-page":"205","volume":"10","author":"JK Lee","year":"1982","unstructured":"Lee JK, Yang KH (1982) Enzyme-linked immunosorbent assay (ELISA) for detection of Clostridium type F toxin. Kor J Appl Microbiol Bioeng 10:205\u2013209","journal-title":"Kor J Appl Microbiol Bioeng"},{"key":"11_CR127","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/BF02284114","volume":"65","author":"J Leuchs","year":"1910","unstructured":"Leuchs J (1910) Beitr\u00e4ge zur Kenntnis des toxins und antitoxins des Bacillus botulinus. Z Hyg 65:55\u201384","journal-title":"Z Hyg"},{"key":"11_CR128","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1128\/aem.42.6.1018-1022.1981","volume":"42","author":"GE Lewis Jr","year":"1981","unstructured":"Lewis GE Jr, Kulinski SS, Reichard DW et al (1981) Detection of Clostridium botulinum type G toxin by enzyme-linked immunosorbent assay. Appl Environ Microbiol 42:1018\u20131022","journal-title":"Appl Environ Microbiol"},{"key":"11_CR129","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1128\/AEM.01882-09","volume":"76","author":"G Lin","year":"2010","unstructured":"Lin G, Tepp WH, Pier CL et al (2010) Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex. Appl Environ Microbiol 76:40\u201347","journal-title":"Appl Environ Microbiol"},{"key":"11_CR130","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.vetmic.2010.04.030","volume":"146","author":"A Lindberg","year":"2010","unstructured":"Lindberg A, Skarin H, Knutsson R et al (2010) Real-time PCR for Clostridium botulinum type C neurotoxin (BoNTC) gene, also covering a chimeric C\/D sequence-application on outbreaks of botulism in poultry. Vet Microbiol 146:118\u2013123","journal-title":"Vet Microbiol"},{"key":"11_CR131","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1128\/CMR.19.2.298-314.2006","volume":"19","author":"M Lindstr\u00f6m","year":"2006","unstructured":"Lindstr\u00f6m M, Korkeala H (2006) Laboratory diagnostics of botulism. Clin Microbiol Rev 19:298\u2013314","journal-title":"Clin Microbiol Rev"},{"key":"11_CR132","doi-asserted-by":"publisher","first-page":"5694","DOI":"10.1128\/AEM.67.12.5694-5699.2001","volume":"67","author":"M Lindstr\u00f6m","year":"2001","unstructured":"Lindstr\u00f6m M, Keto R, Markkula A et al (2001) Multiplex PCR assay for detection and identification of Clostridium botulinum types A, B, E, and F in food and fecal material. Appl Environ Microbiol 67:5694\u20135699","journal-title":"Appl Environ Microbiol"},{"key":"11_CR133","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ab.2012.02.038","volume":"425","author":"YY Liu","year":"2012","unstructured":"Liu YY, Rigsby P, Sesardic D et al (2012) A functional dual-coated (FDC) microtiter plate method to replace the botulinum toxin LD(50) test. Anal Biochem 425:28\u201335","journal-title":"Anal Biochem"},{"key":"11_CR134","doi-asserted-by":"publisher","first-page":"6094","DOI":"10.1128\/AEM.01009-09","volume":"75","author":"C L\u00faquez","year":"2009","unstructured":"L\u00faquez C, Raphael BH, Maslanka SE (2009) Neurotoxin gene clusters in Clostridium botulinum type Ab strains. Appl Environ Microbiol 75:6094\u20136101","journal-title":"Appl Environ Microbiol"},{"key":"11_CR135","doi-asserted-by":"publisher","first-page":"8625","DOI":"10.1128\/AEM.05155-11","volume":"77","author":"TE Macdonald","year":"2011","unstructured":"Macdonald TE, Helma CH, Shou Y et al (2011) Analysis of Clostridium botulinum serotype E strains by using multilocus sequence typing, amplified fragment length polymorphism, variable-number tandem-repeat analysis, and botulinum neurotoxin gene sequencing. Appl Environ Microbiol 77:8625\u20138634","journal-title":"Appl Environ Microbiol"},{"key":"11_CR136","doi-asserted-by":"publisher","first-page":"21950","DOI":"10.1074\/jbc.273.34.21950","volume":"273","author":"AB Maksymowych","year":"1998","unstructured":"Maksymowych AB, Simpson LL (1998) Binding and transcytosis of botulinum neurotoxin by polarized human colon carcinoma cells. J Biol Chem 273:21950\u201321957","journal-title":"J Biol Chem"},{"key":"11_CR137","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1124\/jpet.104.066845","volume":"310","author":"AB Maksymowych","year":"2004","unstructured":"Maksymowych AB, Simpson LL (2004) Structural features of the botulinum neurotoxin molecule that govern binding and transcytosis across polarized human intestinal epithelial cells. J Pharmacol Exp Ther 310:633\u2013641","journal-title":"J Pharmacol Exp Ther"},{"key":"11_CR138","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1038\/nprot.2006.331","volume":"1","author":"JT Mason","year":"2006","unstructured":"Mason JT, Xu L, Sheng ZM et al (2006) Liposome polymerase chain reaction assay for the sub-attomolar detection of cholera toxin and botulinum neurotoxin type A. Nat Protoc 1:2003\u20132011","journal-title":"Nat Protoc"},{"key":"11_CR139","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/0006-291X(82)90708-2","volume":"104","author":"M Matsuda","year":"1982","unstructured":"Matsuda M, Sugimoto N, Ozutsumi K et al (1982) Acute botulinum-like intoxication by tetanus neurotoxin in mice. Biochem Biophys Res Commun 104:799\u2013805","journal-title":"Biochem Biophys Res Commun"},{"key":"11_CR140","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/0041-0101(96)00070-0","volume":"34","author":"K McLellan","year":"1996","unstructured":"McLellan K, Das RE, Ekong TA et al (1996) Therapeutic botulinum type A toxin: factors affecting potency. Toxicon 34:975\u2013985","journal-title":"Toxicon"},{"key":"11_CR141","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s00003-007-0174-y","volume":"2","author":"U Messelh\u00e4usser","year":"2007","unstructured":"Messelh\u00e4usser U, Zucker R, Ziegler H et al (2007) Nachweis von Clostridium botulinum Typ A, B, E und F mittels real-time-PCR. J Verbr Lebensm 2:198\u2013201","journal-title":"J Verbr Lebensm"},{"key":"11_CR142","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/infdis\/45.2.96","volume":"45","author":"KF Meyer","year":"1929","unstructured":"Meyer KF, Gunnison JB (1929) European strains of Cl. botulinum. XXXVI. J Infect Dis 45:96\u2013105","journal-title":"J Infect Dis"},{"key":"11_CR143","first-page":"233","volume":"1","author":"OA Meyer","year":"1979","unstructured":"Meyer OA, Tilson HA, Byrd WC et al (1979) A method for the routine assessment of fore- and hindlimb grip strength of rats and mice. Neurobehav Toxicol 1:233\u2013236","journal-title":"Neurobehav Toxicol"},{"key":"11_CR144","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0022-1759(86)90193-6","volume":"93","author":"M Michalik","year":"1986","unstructured":"Michalik M, Grzybowski J, Ligi\u0119za J et al (1986) Enzyme-linked immunosorbent assay (ELISA) for the detection and differentiation of Clostridium botulinum toxins type A and B. J Immunol Methods 93:225\u2013230","journal-title":"J Immunol Methods"},{"key":"11_CR145","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1699-0463.1960.tb04741.x","volume":"48","author":"V M\u00f8ller","year":"1960","unstructured":"M\u00f8ller V, Scheibel I (1960) Preliminary report on the isolation of an apparently new type of Cl. botulinum. Acta Pathol Microbiol Scand 48:80","journal-title":"Acta Pathol Microbiol Scand"},{"key":"11_CR146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2958.1994.tb00396.x","volume":"13","author":"C Montecucco","year":"1994","unstructured":"Montecucco C, Schiavo G (1994) Mechanism of action of tetanus and botulinum neurotoxins. Mol Microbiol 13:1\u20138","journal-title":"Mol Microbiol"},{"key":"11_CR147","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0167-4781(96)00006-1","volume":"1307","author":"K Moriishi","year":"1996","unstructured":"Moriishi K, Koura M, Abe N et al (1996) Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organisms. Biochim Biophys Acta 1307:123\u2013126","journal-title":"Biochim Biophys Acta"},{"key":"11_CR148","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1574-695X.2010.00774.x","volume":"61","author":"H Moura","year":"2011","unstructured":"Moura H, Terilli RR, Woolfitt AR et al (2011) Studies on botulinum neurotoxins type\/C1 and mosaic\/DC using endopep-MS and proteomics. FEMS Immunol Med Microbiol 61:288\u2013300","journal-title":"FEMS Immunol Med Microbiol"},{"key":"11_CR149","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1101\/SQB.1986.051.01.032","volume":"51","author":"K Mullis","year":"1986","unstructured":"Mullis K, Faloona F, Scharf S et al (1986) Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. Cold Spring Harb Symp Quant Biol 51:263\u2013273","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"11_CR150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7883\/yoken1952.31.81","volume":"31","author":"S Notermans","year":"1978","unstructured":"Notermans S, Dufrenne J, Schothorst M (1978) Enzyme-linked immunosorbent assay for detection of Clostridium botulinum toxin type A. Jpn J Med Sci Biol 31:81\u201385","journal-title":"Jpn J Med Sci Biol"},{"key":"11_CR151","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1128\/aem.37.6.1173-1175.1979","volume":"37","author":"S Notermans","year":"1979","unstructured":"Notermans S, Dufrenne J, Kozaki S (1979) Enzyme-linked immunosorbent assay for detection of Clostridium botulinum type E toxin. Appl Environ Microbiol 37:1173\u20131175","journal-title":"Appl Environ Microbiol"},{"key":"11_CR152","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7883\/yoken1952.35.203","volume":"35","author":"S Notermans","year":"1982","unstructured":"Notermans S, Dufrenne J, Kozaki S (1982a) The relation between toxicity and toxin-related-antigen contents of Clostridium botulinum types C and D cultures as determined by mouse bioassay and ELISA. Jpn J Med Sci Biol 35:203\u2013211","journal-title":"Jpn J Med Sci Biol"},{"key":"11_CR153","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0076-6879(82)84020-2","volume":"84","author":"S Notermans","year":"1982","unstructured":"Notermans S, Hagenaars AM, Kozaki S (1982b) The enzyme-linked immunosorbent assay (ELISA) for the detection and determination of Clostridium botulinum toxins A, B, and E. Methods Enzymol 84:223\u2013238","journal-title":"Methods Enzymol"},{"key":"11_CR154","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0956-5663(99)00061-5","volume":"14","author":"T O\u2019Brien","year":"2000","unstructured":"O\u2019Brien T, Johnson LH 3rd, Aldrich JL et al (2000) The development of immunoassays to four biological threat agents in a bidiffractive grating biosensor. Biosens Bioelectron 14:815\u2013828","journal-title":"Biosens Bioelectron"},{"key":"11_CR155","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/0003-2697(92)90440-I","volume":"205","author":"RA Ogert","year":"1992","unstructured":"Ogert RA, Brown JE, Singh BR et al (1992) Detection of Clostridium botulinum toxin A using a fiber optic-based biosensor. Anal Biochem 205:306\u2013312","journal-title":"Anal Biochem"},{"key":"11_CR156","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1128\/iai.28.2.303-309.1980","volume":"28","author":"I Ohishi","year":"1980","unstructured":"Ohishi I, Sakaguchi G (1980) Oral toxicities of Clostridium botulinum type C and D toxins of different molecular sizes. Infect Immun 28:303\u2013309","journal-title":"Infect Immun"},{"key":"11_CR157","doi-asserted-by":"publisher","first-page":"5783","DOI":"10.1021\/ac9006914","volume":"81","author":"RM Ozanich Jr","year":"2009","unstructured":"Ozanich RM Jr, Bruckner-Lea CJ, Warner MG et al (2009) Rapid multiplexed flow cytometric assay for botulinum neurotoxin detection using an automated fluidic microbead-trapping flow cell for enhanced sensitivity. Anal Chem 81:5783\u20135793","journal-title":"Anal Chem"},{"key":"11_CR158","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1021\/ac201910q","volume":"83","author":"BA Parks","year":"2011","unstructured":"Parks BA, Shearer JD, Baudys J et al (2011) Quantification of botulinum neurotoxin serotypes A and B from serum using mass spectrometry. Anal Chem 83:9047\u20139053","journal-title":"Anal Chem"},{"key":"11_CR159","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1039\/b911525k","volume":"134","author":"D Pauly","year":"2009","unstructured":"Pauly D, Kirchner S, St\u00f6rmann B et al (2009) Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay. Analyst 134:2028\u20132039","journal-title":"Analyst"},{"key":"11_CR160","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1006\/taap.1994.1181","volume":"128","author":"LB Pearce","year":"1994","unstructured":"Pearce LB, Borodic GE, First ER et al (1994) Measurement of botulinum toxin activity: evaluation of the lethality assay. Toxicol Appl Pharmacol 128:69\u201377","journal-title":"Toxicol Appl Pharmacol"},{"issue":"183\u2013265","key":"11_CR161","first-page":"320","volume":"55","author":"MW Peck","year":"2009","unstructured":"Peck MW (2009) Biology and genomic analysis of Clostridium botulinum. Adv Microb Physiol 55(183\u2013265):320","journal-title":"Adv Microb Physiol"},{"key":"11_CR267","doi-asserted-by":"publisher","unstructured":"Pellett S (2012) Progress in cell based assays for botulinum neurotoxin detection. doi: 10.1007\/978-3-642-33570-9-12","DOI":"10.1007\/978-3-642-33570-9-12"},{"key":"11_CR162","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1080\/02652030802060875","volume":"25","author":"RW Phillips","year":"2008","unstructured":"Phillips RW, Abbott D (2008) High-throughput enzyme-linked immunoabsorbant assay (ELISA) electrochemiluminescent detection of botulinum toxins in foods for food safety and defence purposes. Food Addit Contam 25:1084\u20131088","journal-title":"Food Addit Contam"},{"key":"11_CR163","doi-asserted-by":"publisher","first-page":"7815","DOI":"10.1128\/AEM.06165-11","volume":"77","author":"TM Piazza","year":"2011","unstructured":"Piazza TM, Blehert DS, Dunning FM et al (2011) In vitro detection and quantification of botulinum neurotoxin type E activity in avian blood. Appl Environ Microbiol 77:7815\u20137822","journal-title":"Appl Environ Microbiol"},{"key":"11_CR164","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.febslet.2010.11.045","volume":"585","author":"CL Pier","year":"2011","unstructured":"Pier CL, Chen C, Tepp WH et al (2011) Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. FEBS Lett 585:199\u2013206","journal-title":"FEBS Lett"},{"key":"11_CR165","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.toxicon.2008.12.016","volume":"53","author":"M Pires-Alves","year":"2009","unstructured":"Pires-Alves M, Ho M, Aberle KK et al (2009) Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity. Toxicon 53:392\u2013399","journal-title":"Toxicon"},{"key":"11_CR166","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0041-0101(01)00288-4","volume":"40","author":"MA Poli","year":"2002","unstructured":"Poli MA, Rivera VR, Neal D (2002) Development of sensitive colorimetric capture ELISAs for Clostridium botulinum neurotoxin serotypes E and F. Toxicon 40:797\u2013802","journal-title":"Toxicon"},{"key":"11_CR167","first-page":"137","volume":"216","author":"MR Popoff","year":"2003","unstructured":"Popoff MR, Walker JM (2003) Detection of toxigenic Clostridia. Methods Mol Biol 216:137\u2013152","journal-title":"Methods Mol Biol"},{"key":"11_CR168","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1128\/AEM.00091-09","volume":"75","author":"H Poras","year":"2009","unstructured":"Poras H, Ouimet T, Orng SV et al (2009) Detection and quantification of botulinum neurotoxin type a by a novel rapid in vitro fluorimetric assay. Appl Environ Microbiol 75:4382\u20134390","journal-title":"Appl Environ Microbiol"},{"key":"11_CR169","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00216-008-2287-2","volume":"393","author":"GA Posthuma-Trumpie","year":"2009","unstructured":"Posthuma-Trumpie GA, Korf J, van Amerongen A (2009) Lateral flow (immuno)assay: its strengths, weaknesses, opportunities and threats. A literature survey. Anal Bioanal Chem 393:569\u2013582","journal-title":"Anal Bioanal Chem"},{"key":"11_CR170","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4315\/0362-028X-56.10.856","volume":"56","author":"MD Potter","year":"1993","unstructured":"Potter MD, Meng JH, Kinsey P (1993) An ELISA for detection of botulinal toxin types A, B, and E in inoculated food samples. J Food Protect 56:856\u2013861","journal-title":"J Food Protect"},{"key":"11_CR171","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1111\/j.1471-4159.1993.tb03640.x","volume":"61","author":"B Poulain","year":"1993","unstructured":"Poulain B, Rossetto O, Deloye F et al (1993) Antibodies against rat brain vesicle-associated membrane protein (synaptobrevin) prevent inhibition of acetylcholine release by tetanus toxin or botulinum neurotoxin type B. J Neurochem 61:1175\u20131178","journal-title":"J Neurochem"},{"key":"11_CR172","first-page":"975","volume":"130","author":"IR Poxton","year":"1984","unstructured":"Poxton IR (1984) Demonstration of the common antigens of Clostridium botulinum, C. sporogenes and C. novyi by an enzyme-linked immunosorbent assay and electroblot transfer. J Gen Microbiol 130:975\u2013981","journal-title":"J Gen Microbiol"},{"key":"11_CR173","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1099\/00222615-17-2-171","volume":"17","author":"IR Poxton","year":"1984","unstructured":"Poxton IR, Byrne MD (1984) Demonstration of shared antigens in the genus Clostridium by an enzyme-linked immunosorbent assay. J Med Microbiol 17:171\u2013176","journal-title":"J Med Microbiol"},{"key":"11_CR174","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1863-2378.2007.01070.x","volume":"54","author":"V Pr\u00e9vot","year":"2007","unstructured":"Pr\u00e9vot V, Tweepenninckx F, van Nerom E et al (2007) Optimization of polymerase chain reaction for detection of Clostridium botulinum type C and D in bovine samples. Zoonoses Public Health 54:320\u2013327","journal-title":"Zoonoses Public Health"},{"key":"11_CR175","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s12161-011-9300-7","volume":"5","author":"A Rajkovic","year":"2012","unstructured":"Rajkovic A, El Moualij B, Fikri Y et al (2012) Detection of Clostridium botulinum neurotoxins A and B in milk by ELISA and immuno-PCR at higher sensitivity than mouse bio-assay. Food Anal Methods 5:319\u2013326","journal-title":"Food Anal Methods"},{"key":"11_CR176","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.mimet.2007.09.016","volume":"71","author":"BH Raphael","year":"2007","unstructured":"Raphael BH, Andreadis JD (2007) Real-time PCR detection of the nontoxic nonhemagglutinin gene as a rapid screening method for bacterial isolates harboring the botulinum neurotoxin (A\u2013G) gene complex. J Microbiol Methods 71:343\u2013346","journal-title":"J Microbiol Methods"},{"key":"11_CR177","doi-asserted-by":"publisher","first-page":"4390","DOI":"10.1128\/AEM.00260-08","volume":"74","author":"BH Raphael","year":"2008","unstructured":"Raphael BH, Luquez C, McCroskey LM et al (2008) Genetic homogeneity of Clostridium botulinum type A1 strains with unique toxin gene clusters. Appl Environ Microbiol 74:4390\u20134397","journal-title":"Appl Environ Microbiol"},{"key":"11_CR178","doi-asserted-by":"publisher","first-page":"4805","DOI":"10.1128\/AEM.03109-09","volume":"76","author":"BH Raphael","year":"2010","unstructured":"Raphael BH, Choudoir MJ, Luquez C et al (2010a) Sequence diversity of genes encoding botulinum neurotoxin type F. Appl Environ Microbiol 76:4805\u20134812","journal-title":"Appl Environ Microbiol"},{"key":"11_CR179","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.mcp.2009.12.003","volume":"24","author":"BH Raphael","year":"2010","unstructured":"Raphael BH, Joseph LA, McCroskey LM et al (2010b) Detection and differentiation of Clostridium botulinum type A strains using a focused DNA microarray. Mol Cell Probes 24:146\u2013153","journal-title":"Mol Cell Probes"},{"key":"11_CR180","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.toxicon.2009.01.019","volume":"53","author":"C Rasetti-Escargueil","year":"2009","unstructured":"Rasetti-Escargueil C, Jones RG, Liu Y et al (2009) Measurement of botulinum types A, B and E neurotoxicity using the phrenic nerve-hemidiaphragm: improved precision with in-bred mice. Toxicon 53:503\u2013511","journal-title":"Toxicon"},{"key":"11_CR181","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.toxicon.2011.04.003","volume":"57","author":"C Rasetti-Escargueil","year":"2011","unstructured":"Rasetti-Escargueil C, Liu Y, Rigsby P et al (2011) Phrenic nerve-hemidiaphragm as a highly sensitive replacement assay for determination of functional botulinum toxin antibodies. Toxicon 57:1008\u20131016","journal-title":"Toxicon"},{"key":"11_CR182","doi-asserted-by":"publisher","first-page":"4309","DOI":"10.1128\/AEM.00617-08","volume":"74","author":"R Rasooly","year":"2008","unstructured":"Rasooly R, Do PM (2008) Development of an in vitro activity assay as an alternative to the mouse bioassay for Clostridium botulinum neurotoxin type A. Appl Environ Microbiol 74:4309\u20134313","journal-title":"Appl Environ Microbiol"},{"key":"11_CR183","doi-asserted-by":"publisher","first-page":"12557","DOI":"10.1021\/jf1028398","volume":"58","author":"R Rasooly","year":"2010","unstructured":"Rasooly R, Do PM (2010) Clostridium botulinum neurotoxin type B Is heat-stable in milk and not inactivated by pasteurization. J Agric Food Chem 58:12557\u201312561","journal-title":"J Agric Food Chem"},{"key":"11_CR184","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ijfoodmicro.2008.05.012","volume":"126","author":"R Rasooly","year":"2008","unstructured":"Rasooly R, Stanker LH, Carter JM et al (2008) Detection of botulinum neurotoxin-A activity in food by peptide cleavage assay. Int J Food Microbiol 126:135\u2013139","journal-title":"Int J Food Microbiol"},{"key":"11_CR185","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/pssc.201100296","volume":"9","author":"F Ren","year":"2012","unstructured":"Ren F, Pearton SJ (2012) Sensors using AlGaN\/GaN based high electron mobility transistor for environmental and bio-applications. Phys Status Solidi C 9:393\u2013398","journal-title":"Phys Status Solidi C"},{"key":"11_CR186","doi-asserted-by":"publisher","first-page":"15650","DOI":"10.1523\/JNEUROSCI.2618-11.2011","volume":"31","author":"L Restani","year":"2011","unstructured":"Restani L, Antonucci F, Gianfranceschi L et al (2011) Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT\/A). J Neurosci 31:15650\u201315659","journal-title":"J Neurosci"},{"key":"11_CR187","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ab.2006.02.030","volume":"353","author":"VR Rivera","year":"2006","unstructured":"Rivera VR, Gamez FJ, Keener WK et al (2006) Rapid detection of Clostridium botulinum toxins A, B, E, and F in clinical samples, selected food matrices, and buffer using paramagnetic bead-based electrochemiluminescence detection. Anal Biochem 353:248\u2013256","journal-title":"Anal Biochem"},{"key":"11_CR188","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.ab.2011.01.002","volume":"411","author":"DR Ruge","year":"2011","unstructured":"Ruge DR, Dunning FM, Piazza TM et al (2011) Detection of six serotypes of botulinum neurotoxin using fluorogenic reporters. Anal Biochem 411:200\u2013209","journal-title":"Anal Biochem"},{"key":"11_CR268","doi-asserted-by":"publisher","unstructured":"Rummel A (2012) Double Receptor ancharage of botulinum neurotoxins accounts for thier exquisite neurospecificity. doi: 10.1007\/978-3-642-3-570-9-4","DOI":"10.1007\/978-3-642-3-570-9-4"},{"key":"11_CR189","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1126\/science.2448875","volume":"239","author":"RK Saiki","year":"1988","unstructured":"Saiki RK, Gelfand DH, Stoffel S et al (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487\u2013491","journal-title":"Science"},{"key":"11_CR190","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0163-7258(82)90061-4","volume":"19","author":"G Sakaguchi","year":"1982","unstructured":"Sakaguchi G (1982) Clostridium botulinum toxins. Pharmacol Ther 19:165\u2013194","journal-title":"Pharmacol Ther"},{"key":"11_CR191","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7883\/yoken1952.27.161","volume":"27","author":"G Sakaguchi","year":"1974","unstructured":"Sakaguchi G, Sakaguchi S, Kozaki S et al (1974) Cross reaction in reversed passive hemagglutination between Clostridium botulinum type A and B toxins and its avoidance by the sue of anti-toxic component immunoglobulin isolated by affinity chromatography. Jpn J Med Sci Biol 27:161\u2013172","journal-title":"Jpn J Med Sci Biol"},{"key":"11_CR192","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.toxicon.2009.06.020","volume":"54","author":"T Sakamoto","year":"2009","unstructured":"Sakamoto T, Torii Y, Takahashi M et al (2009) Quantitative determination of the biological activity of botulinum toxin type A by measuring the compound muscle action potential (CMAP) in rats. Toxicon 54:857\u2013861","journal-title":"Toxicon"},{"key":"11_CR193","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1111\/j.1365-2672.2008.04084.x","volume":"106","author":"T Sakuma","year":"2009","unstructured":"Sakuma T, Kurosaki Y, Fujinami Y et al (2009) Rapid and simple detection of Clostridium botulinum types A and B by loop-mediated isothermal amplification. J Appl Microbiol 106:1252\u20131259","journal-title":"J Appl Microbiol"},{"key":"11_CR194","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00217-007-0746-1","volume":"227","author":"L S\u00e1nchez-Hern\u00e1ndez","year":"2008","unstructured":"S\u00e1nchez-Hern\u00e1ndez L, Cifuentes A, Jim\u00e9nez B et al (2008) Detection of Clostridium botulinum neurotoxin coding genes: analysis of PCR products by real time versus capillary gel electrophoresis methods. Eur Food Res Technol 227:495\u2013502","journal-title":"Eur Food Res Technol"},{"key":"11_CR195","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.1128\/AEM.71.9.5590-5592.2005","volume":"71","author":"KE Sapsford","year":"2005","unstructured":"Sapsford KE, Taitt CR, Loo N et al (2005) Biosensor detection of botulinum toxoid A and staphylococcal enterotoxin B in food. Appl Environ Microbiol 71:5590\u20135592","journal-title":"Appl Environ Microbiol"},{"key":"11_CR196","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.bios.2008.06.018","volume":"24","author":"KE Sapsford","year":"2008","unstructured":"Sapsford KE, Sun S, Francis J et al (2008) A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity. Biosens Bioelectron 24:618\u2013625","journal-title":"Biosens Bioelectron"},{"key":"11_CR197","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1099\/jmm.0.012567-0","volume":"59","author":"BA Satterfield","year":"2010","unstructured":"Satterfield BA, Stewart AF, Lew CS et al (2010) A quadruplex real-time PCR assay for rapid detection and differentiation of the Clostridium botulinum toxin genes A, B, E and F. J Med Microbiol 59:55\u201364","journal-title":"J Med Microbiol"},{"key":"11_CR198","doi-asserted-by":"crossref","first-page":"23784","DOI":"10.1016\/S0021-9258(20)80452-9","volume":"268","author":"G Schiavo","year":"1993","unstructured":"Schiavo G, Rossetto O, Catsicas S et al (1993) Identification of the nerve terminal targets of botulinum serotypes A, D, and E. J Biol Chem 268:23784\u201323786","journal-title":"J Biol Chem"},{"key":"11_CR199","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1006\/abio.2001.5236","volume":"296","author":"JJ Schmidt","year":"2001","unstructured":"Schmidt JJ, Stafford RG, Millard CB (2001) High-throughput assays for botulinum neurotoxin proteolytic activity: serotypes A, B, D, and F. Anal Biochem 296:130\u2013137","journal-title":"Anal Biochem"},{"key":"11_CR200","doi-asserted-by":"publisher","first-page":"e11047","DOI":"10.1371\/journal.pone.0011047","volume":"5","author":"MC Scotcher","year":"2010","unstructured":"Scotcher MC, Cheng LW, Stanker LH (2010) Detection of botulinum neurotoxin serotype B at sub mouse LD50 levels by a sandwich immunoassay and its application to toxin detection in milk. PLoS ONE 5:e11047","journal-title":"PLoS ONE"},{"key":"11_CR201","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0368-1742(22)80021-7","volume":"35","author":"HR Seddon","year":"1922","unstructured":"Seddon HR (1922) Bulbar paralysis in cattle due to the action of toxicogenic bacillus, with a discussion on the relationship of the condition to forage poisoning (botulism). J Comp Pathol Therapeut 35:147\u2013190","journal-title":"J Comp Pathol Therapeut"},{"key":"11_CR202","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1600-0773.1996.tb01376.x","volume":"78","author":"D Sesardic","year":"1996","unstructured":"Sesardic D, McLellan K, Ekong TA et al (1996) Refinement and validation of an alternative bioassay for potency testing of therapeutic botulinum type A toxin. Pharmacol Toxicol 78:283\u2013288","journal-title":"Pharmacol Toxicol"},{"key":"11_CR203","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.biologicals.2003.08.001","volume":"31","author":"D Sesardic","year":"2003","unstructured":"Sesardic D, Leung T, Gaines Das R (2003) Role for standards in assays of botulinum toxins: international collaborative study of three preparations of botulinum type A toxin. Biologicals 31:265\u2013276","journal-title":"Biologicals"},{"key":"11_CR204","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1002\/mds.20021","volume":"19","author":"D Sesardic","year":"2004","unstructured":"Sesardic D, Jones RG, Leung T et al (2004) Detection of antibodies against botulinum toxins. Mov Disord 19:S85\u2013S91","journal-title":"Mov Disord"},{"key":"11_CR205","doi-asserted-by":"publisher","first-page":"3935","DOI":"10.1128\/AEM.71.7.3935-3941.2005","volume":"71","author":"SK Sharma","year":"2005","unstructured":"Sharma SK, Eblen BS, Bull RL et al (2005) Evaluation of lateral-flow Clostridium botulinum neurotoxin detection kits for food analysis. Appl Environ Microbiol 71:3935\u20133941","journal-title":"Appl Environ Microbiol"},{"key":"11_CR206","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1128\/AEM.72.2.1231-1238.2006","volume":"72","author":"SK Sharma","year":"2006","unstructured":"Sharma SK, Ferreira JL, Eblen BS et al (2006) Detection of type A, B, E, and F Clostridium botulinum neurotoxins in foods by using an amplified enzyme-linked immunosorbent assay with digoxigenin-labeled antibodies. Appl Environ Microbiol 72:1231\u20131238","journal-title":"Appl Environ Microbiol"},{"key":"11_CR207","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1016-8478(23)07347-8","volume":"24","author":"NR Shin","year":"2007","unstructured":"Shin NR, Yoon SY, Shin JH et al (2007) Development of enrichment semi-nested PCR for Clostridium botulinum types A, B, E, and F and its application to Korean environmental samples. Mol Cells 24:329\u2013337","journal-title":"Mol Cells"},{"key":"11_CR208","unstructured":"Shine N, Eaton L, Crawford K (2002) A continuous fluorimetric assay for high throughput screening for BoNT\/A inhibitors. Naunyns Schmiedebergs Arch Pharmacol 365(Suppl. 2), Abstract R128"},{"key":"11_CR209","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1128\/aem.50.1.63-67.1985","volume":"50","author":"C Shone","year":"1985","unstructured":"Shone C, Wilton-Smith P, Appleton N et al (1985) Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bioassay. Appl Environ Microbiol 50:63\u201367","journal-title":"Appl Environ Microbiol"},{"key":"11_CR210","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0925-4005(93)85261-8","volume":"11","author":"LC Shriver-Lake","year":"1993","unstructured":"Shriver-Lake LC, Ogert RA, Ligler FS (1993) A fiber-optic evanescent-wave immunosensor for large molecules. Sens Actuators B Chem 11:239\u2013243","journal-title":"Sens Actuators B Chem"},{"key":"11_CR211","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0028-3908(73)90085-3","volume":"12","author":"LL Simpson","year":"1973","unstructured":"Simpson LL (1973) The interaction between divalent cations and botulinum toxin type A in the paralysis of the rat phrenic nerve-hemidiaphragm preparation. Neuropharmacology 12:165\u2013176","journal-title":"Neuropharmacology"},{"key":"11_CR212","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/0028-3908(74)90014-8","volume":"13","author":"LL Simpson","year":"1974","unstructured":"Simpson LL (1974) Studies on the binding of botulinum toxin type A to the rat phrenic nerve-hemidiaphragm preparation. Neuropharmacology 13:683\u2013691","journal-title":"Neuropharmacology"},{"key":"11_CR213","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev.pharmtox.44.101802.121554","volume":"44","author":"LL Simpson","year":"2004","unstructured":"Simpson LL (2004) Identification of the major steps in botulinum toxin action. Annu Rev Pharmacol Toxicol 44:167\u2013193","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"11_CR214","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/0028-3908(67)90048-2","volume":"6","author":"LL Simpson","year":"1967","unstructured":"Simpson LL, Tapp JT (1967) Actions of calcium and magnesium on the rate of onset of botulinum toxin paralysis of the rat diaphragm. Int J Neuropharmacol 6:485\u2013492","journal-title":"Int J Neuropharmacol"},{"key":"11_CR215","doi-asserted-by":"publisher","first-page":"5450","DOI":"10.1128\/IAI.73.9.5450-5457.2005","volume":"73","author":"TJ Smith","year":"2005","unstructured":"Smith TJ, Lou J, Geren IN et al (2005) Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect Immun 73:5450\u20135457","journal-title":"Infect Immun"},{"key":"11_CR216","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jim.2008.03.003","volume":"336","author":"LH Stanker","year":"2008","unstructured":"Stanker LH, Merrill P, Scotcher MC et al (2008) Development and partial characterization of high-affinity monoclonal antibodies for botulinum toxin type A and their use in analysis of milk by sandwich ELISA. J Immunol Methods 336:1\u20138","journal-title":"J Immunol Methods"},{"key":"11_CR217","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.febslet.2011.12.037","volume":"586","author":"J Strotmeier","year":"2012","unstructured":"Strotmeier J, Willjes G, Binz T et al (2012) Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity. FEBS Lett 586:310\u2013313","journal-title":"FEBS Lett"},{"key":"11_CR218","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/mr.44.3.419-448.1980","volume":"44","author":"H Sugiyama","year":"1980","unstructured":"Sugiyama H (1980) Clostridium botulinum neurotoxin. Microbiol Rev 44:419\u2013448","journal-title":"Microbiol Rev"},{"key":"11_CR219","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1128\/am.27.2.333-336.1974","volume":"27","author":"H Sugiyama","year":"1974","unstructured":"Sugiyama H, Oishi I, Dasgupta BR (1974) Evaluation of type A botulinal toxin assays that use antitoxin to crystalline toxin. Appl Microbiol 27:333\u2013336","journal-title":"Appl Microbiol"},{"key":"11_CR220","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1128\/am.30.3.420-423.1975","volume":"30","author":"H Sugiyama","year":"1975","unstructured":"Sugiyama H, Brenner SL, Dasgupta BR (1975) Detection of Clostridium botulinum toxin by local paralysis elicited with intramuscular challenge. Appl Microbiol 30:420\u2013423","journal-title":"Appl Microbiol"},{"key":"11_CR221","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1039\/b912097a","volume":"9","author":"S Sun","year":"2009","unstructured":"Sun S, Ossandon M, Kostov Y et al (2009) Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis. Lab Chip 9:3275\u20133281","journal-title":"Lab Chip"},{"key":"11_CR222","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.snb.2010.02.009","volume":"146","author":"S Sun","year":"2010","unstructured":"Sun S, Francis J, Sapsford KE et al (2010) Multi-wavelength Spatial LED illumination based detector for in vitro detection of botulinum neurotoxin A activity. Sens Actuators B Chem 146:297\u2013306","journal-title":"Sens Actuators B Chem"},{"key":"11_CR223","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1128\/aem.58.1.418-420.1992","volume":"58","author":"EA Szabo","year":"1992","unstructured":"Szabo EA, Pemberton JM, Desmarchelier PM (1992) Specific detection of Clostridium botulinum type B by using the polymerase chain reaction. Appl Environ Microbiol 58:418\u2013420","journal-title":"Appl Environ Microbiol"},{"key":"11_CR224","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1128\/aem.59.9.3011-3020.1993","volume":"59","author":"EA Szabo","year":"1993","unstructured":"Szabo EA, Pemberton JM, Desmarchelier PM (1993) Detection of the genes encoding botulinum neurotoxin types A to E by the polymerase chain reaction. Appl Environ Microbiol 59:3011\u20133020","journal-title":"Appl Environ Microbiol"},{"key":"11_CR225","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1365-2672.1994.tb01650.x","volume":"76","author":"EA Szabo","year":"1994","unstructured":"Szabo EA, Pemberton JM, Gibson AM et al (1994) Polymerase chain reaction for detection of Clostridium botulinum types A, B and E in food, soil and infant faeces. J Appl Bacteriol 76:539\u2013545","journal-title":"J Appl Bacteriol"},{"key":"11_CR226","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0041-0101(99)00168-3","volume":"38","author":"M Sz\u00edlagyi","year":"2000","unstructured":"Sz\u00edlagyi M, Rivera VR, Neal D et al (2000) Development of sensitive colorimetric capture ELISAs for Clostridium botulinum neurotoxin serotypes A and B. Toxicon 38:381\u2013389","journal-title":"Toxicon"},{"key":"11_CR227","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0168-1605(90)90020-6","volume":"11","author":"M Takahashi","year":"1990","unstructured":"Takahashi M, Kameyama S, Sakaguchi G (1990) Assay in mice for low levels of Clostridium botulinum toxin. Int J Food Microbiol 11:271\u2013277","journal-title":"Int J Food Microbiol"},{"key":"11_CR228","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4315\/0362-028X-73.4.688","volume":"73","author":"H Takahashi","year":"2010","unstructured":"Takahashi H, Takakura C, Kimura B (2010) A quantitative real-time PCR method for monitoring Clostridium botulinum type A in rice samples. J Food Prot 73:688\u2013694","journal-title":"J Food Prot"},{"key":"11_CR229","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1637\/7347-022305R1.1","volume":"49","author":"M Takeda","year":"2005","unstructured":"Takeda M, Tsukamoto K, Kohda T et al (2005) Characterization of the neurotoxin produced by isolates associated with avian botulism. Avian Dis 49:376\u2013381","journal-title":"Avian Dis"},{"key":"11_CR230","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1348-0421.1996.tb03310.x","volume":"40","author":"K Takeshi","year":"1996","unstructured":"Takeshi K, Fujinaga Y, Inoue K et al (1996) Simple method for detection of Clostridium botulinum type A to F neurotoxin genes by ploymerase chain reaction. Microbiol Immunol 40:5\u201311","journal-title":"Microbiol Immunol"},{"key":"11_CR231","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/1471-2180-11-232","volume":"11","author":"RR Terilli","year":"2011","unstructured":"Terilli RR, Moura H, Woolfitt AR et al (2011) A historical and proteomic analysis of botulinum neurotoxin type\/G. BMC Microbiol 11:232","journal-title":"BMC Microbiol"},{"key":"11_CR232","first-page":"165","volume":"31","author":"A Theiler","year":"1927","unstructured":"Theiler A, Robinson EM (1927) Der Botulismus der Haustiere. Z Infektionskr Haustiere 31:165\u2013220","journal-title":"Z Infektionskr Haustiere"},{"key":"11_CR233","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1751-0813.1991.tb00769.x","volume":"68","author":"RJ Thomas","year":"1991","unstructured":"Thomas RJ (1991) Detection of Clostridium botulinum types C and D toxin by ELISA. Aust Vet J 68:111\u2013113","journal-title":"Aust Vet J"},{"key":"11_CR234","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.toxicon.2009.09.005","volume":"55","author":"Y Torii","year":"2010","unstructured":"Torii Y, Goto Y, Takahashi M et al (2010a) Quantitative determination of biological activity of botulinum toxins utilizing compound muscle action potentials (CMAP), and comparison of neuromuscular transmission blockage and muscle flaccidity among toxins. Toxicon 55:407\u2013414","journal-title":"Toxicon"},{"key":"11_CR235","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.toxicon.2009.09.004","volume":"55","author":"Y Torii","year":"2010","unstructured":"Torii Y, Takahashi M, Ishida S et al (2010b) Quantification of potency of neutralizing antibodies to botulinum toxin using compound muscle action potential (CMAP). Toxicon 55:662\u2013665","journal-title":"Toxicon"},{"key":"11_CR236","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.toxicon.2010.10.009","volume":"57","author":"Y Torii","year":"2011","unstructured":"Torii Y, Kiyota N, Sugimoto N et al (2011) Comparison of effects of botulinum toxin subtype A1 and A2 using twitch tension assay and rat grip strength test. Toxicon 57:93\u201399","journal-title":"Toxicon"},{"key":"11_CR237","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1128\/JCM.00077-09","volume":"47","author":"K Umeda","year":"2009","unstructured":"Umeda K, Seto Y, Kohda T et al (2009) Genetic characterization of Clostridium botulinum associated with type B infant botulism in Japan. J Clin Microbiol 47:2720\u20132728","journal-title":"J Clin Microbiol"},{"key":"11_CR238","first-page":"308","volume":"54","author":"K Umeda","year":"2010","unstructured":"Umeda K, Seto Y, Kohda T et al (2010) A novel multiplex PCR method for Clostridium botulinum neurotoxin type A gene cluster typing. Microbiol Immunol 54:308\u2013312","journal-title":"Microbiol Immunol"},{"key":"11_CR239","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0021-9673(02)00508-3","volume":"970","author":"BL van Baar","year":"2002","unstructured":"van Baar BL, Hulst AG, de Jong AL et al (2002) Characterisation of botulinum toxins type A and B, by matrix-assisted laser desorption ionisation and electrospray mass spectrometry. J Chromatogr A 970:95\u2013115","journal-title":"J Chromatogr A"},{"key":"11_CR240","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.chroma.2004.02.047","volume":"1035","author":"BL van Baar","year":"2004","unstructured":"van Baar BL, Hulst AG, de Jong AL et al (2004) Characterisation of botulinum toxins type C, D, E, and F by matrix-assisted laser desorption ionisation and electrospray mass spectrometry. J Chromatogr A 1035:97\u2013114","journal-title":"J Chromatogr A"},{"key":"11_CR241","first-page":"1","volume":"26","author":"E van Ermengem","year":"1897","unstructured":"van Ermengem E (1897) Ueber einen neuen ana\u00ebroben Bacillus und seine Beziehungen zum Botulismus. Z Hyg 26:1\u201356","journal-title":"Z Hyg"},{"key":"11_CR242","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.aca.2006.04.047","volume":"570","author":"SM Varnum","year":"2006","unstructured":"Varnum SM, Warner MG, Dockendorff B et al (2006) Enzyme-amplified protein microarray and a fluidic renewable surface fluorescence immunoassay for botulinum neurotoxin detection using high-affinity recombinant antibodies. Anal Chim Acta 570:137\u2013143","journal-title":"Anal Chim Acta"},{"key":"11_CR243","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0022-1759(84)90092-9","volume":"67","author":"R Viscidi","year":"1984","unstructured":"Viscidi R, Laughon BE, Hanvanich M et al (1984) Improved enzyme immunoassays for the detection of antigens in fecal specimens. Investigation and correction of interfering factors. J Immunol Methods 67:129\u2013143","journal-title":"J Immunol Methods"},{"key":"11_CR244","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jim.2007.11.006","volume":"330","author":"H Volland","year":"2008","unstructured":"Volland H, Lamourette P, Nevers M-C et al (2008) A sensitive sandwich enzyme immunoassay for free or complexed Clostridium botulinum neurotoxin type A. J Immunol Methods 330:120\u2013129","journal-title":"J Immunol Methods"},{"key":"11_CR245","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ab.2011.01.025","volume":"412","author":"D Wang","year":"2011","unstructured":"Wang D, Baudys J, Kalb SR et al (2011) Improved detection of botulinum neurotoxin type A in stool by mass spectrometry. Anal Biochem 412:67\u201373","journal-title":"Anal Biochem"},{"key":"11_CR246","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bios.2009.06.031","volume":"25","author":"MG Warner","year":"2009","unstructured":"Warner MG, Grate JW, Tyler A et al (2009) Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodies. Biosens Bioelectron 25:179\u2013184","journal-title":"Biosens Bioelectron"},{"key":"11_CR247","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1128\/AEM.02937-09","volume":"76","author":"OG Weingart","year":"2010","unstructured":"Weingart OG, Schreiber T, Mascher C et al (2010) The case of botulinum toxin in milk: experimental data. Appl Environ Microbiol 76:3293\u20133300","journal-title":"Appl Environ Microbiol"},{"key":"11_CR248","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.3390\/s120202324","volume":"12","author":"OG Weingart","year":"2012","unstructured":"Weingart OG, Gao H, Crevoisier F et al (2012) A bioanalytical platform for simultaneous detection and quantification of biological toxins. Sensors (Basel) 12:2324\u20132339","journal-title":"Sensors (Basel)"},{"key":"11_CR249","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1128\/AEM.65.9.3787-3792.1999","volume":"65","author":"M Wictome","year":"1999","unstructured":"Wictome M, Newton K, Jameson K et al (1999a) Development of an in vitro bioassay for Clostridium botulinum type B neurotoxin in foods that is more sensitive than the mouse bioassay. Appl Environ Microbiol 65:3787\u20133792","journal-title":"Appl Environ Microbiol"},{"key":"11_CR250","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1574-695X.1999.tb01300.x","volume":"24","author":"M Wictome","year":"1999","unstructured":"Wictome M, Newton KA, Jameson K et al (1999b) Development of in vitro assays for the detection of botulinum toxins in foods. FEMS Immunol Med Microbiol 24:319\u2013323","journal-title":"FEMS Immunol Med Microbiol"},{"key":"11_CR251","first-page":"235","volume":"61","author":"TD Wilder-Kofie","year":"2011","unstructured":"Wilder-Kofie TD, L\u00faquez C, Adler M et al (2011) An alternative in vivo method to refine the mouse bioassay for botulinum toxin detection. Comp Med 61:235\u2013242","journal-title":"Comp Med"},{"key":"11_CR252","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.1128\/AEM.07568-11","volume":"78","author":"C Woudstra","year":"2012","unstructured":"Woudstra C, Skarin H, Anniballi F et al (2012) Neurotoxin gene profiling of Clostridium botulinum types C and D native to different countries within Europe. Appl Environ Microbiol 78:3120\u20133127","journal-title":"Appl Environ Microbiol"},{"key":"11_CR253","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1046\/j.1472-765X.2001.00909.x","volume":"32","author":"HC Wu","year":"2001","unstructured":"Wu HC, Huang YL, Lai SC et al (2001) Detection of Clostridium botulinum neurotoxin type A using immuno-PCR. Lett Appl Microbiol 32:321\u2013325","journal-title":"Lett Appl Microbiol"},{"key":"11_CR254","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11419-007-0031-9","volume":"25","author":"S Yamashiro","year":"2007","unstructured":"Yamashiro S, Sano Y, Komano A et al (2007) Detection of proteinous toxins using the bio-threat alert system, part 4. Differences in detectability according to manufactural lots and according to toxin subtypes. Forensic Toxicol 25:80\u201383","journal-title":"Forensic Toxicol"},{"key":"11_CR255","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1348-0421.2005.tb03755.x","volume":"49","author":"SY Yoon","year":"2005","unstructured":"Yoon SY, Chung GT, Kang DH et al (2005) Application of real-time PCR for quantitative detection of Clostridium botulinum type A toxin gene in food. Microbiol Immunol 49:505\u2013511","journal-title":"Microbiol Immunol"}],"container-title":["Current Topics in Microbiology and Immunology","Botulinum Neurotoxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-33570-9_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T10:04:47Z","timestamp":1710497087000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-642-33570-9_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9783642335693","9783642335709"],"references-count":264,"aliases":["10.1007\/978-3-662-45790-0_11"],"URL":"https:\/\/doi.org\/10.1007\/978-3-642-33570-9_11","relation":{},"ISSN":["0070-217X"],"issn-type":[{"value":"0070-217X","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"14 December 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}