{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:44:38Z","timestamp":1772829878888,"version":"3.50.1"},"publisher-location":"Berlin, Heidelberg","reference-count":29,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642391453","type":"print"},{"value":"9783642391460","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013]]},"DOI":"10.1007\/978-3-642-39146-0_18","type":"book-chapter","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T01:46:34Z","timestamp":1372211194000},"page":"195-206","source":"Crossref","is-referenced-by-count":11,"title":["On Knowledge Discovery in Open Medical Data on the Example of the FDA Drug Adverse Event Reporting System for Alendronate (Fosamax)"],"prefix":"10.1007","author":[{"given":"Pinar","family":"Yildirim","sequence":"first","affiliation":[]},{"given":"Ilyas Ozgur","family":"Ekmekci","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Holzinger","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"18_CR1","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1016\/S0140-6736(11)60647-8","volume":"377","author":"G. Boulton","year":"2011","unstructured":"Boulton, G., Rawlins, M., Vallance, P., Walport, M.: Science as a public enterprise: the case for open data. The Lancet\u00a0377, 1633\u20131635 (2011)","journal-title":"The Lancet"},{"key":"18_CR2","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1126\/science.289.5486.1881","volume":"289","author":"L. Rowen","year":"2000","unstructured":"Rowen, L., Wong, G.K.S., Lane, R.P., Hood, L.: Intellectual property - Publication rights in the era of open data release policies. Science\u00a0289, 1881 (2000)","journal-title":"Science"},{"key":"18_CR3","doi-asserted-by":"crossref","unstructured":"Thompson, M., Heneghan, C.: BMJ OPEN DATA CAMPAIGN We need to move the debate on open clinical trial data forward. British Medical Journal\u00a0345 (2012)","DOI":"10.1136\/bmj.e8351"},{"key":"18_CR4","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.4155\/fmc.12.159","volume":"4","author":"A. Hersey","year":"2012","unstructured":"Hersey, A., Senger, S., Overington, J.P.: Open data for drug discovery: learning from the biological community. Future Medicinal Chemistry\u00a04, 1865\u20131867 (2012)","journal-title":"Future Medicinal Chemistry"},{"key":"18_CR5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0140-6736(10)62234-9","volume":"377","author":"M. Walport","year":"2011","unstructured":"Walport, M., Brest, P.: Sharing research data to improve public health. The Lancet\u00a0377, 537\u2013539 (2011)","journal-title":"The Lancet"},{"issue":"1","key":"18_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2196\/jmir.1629","volume":"14","author":"K. Emam El","year":"2012","unstructured":"El Emam, K., Arbuckle, L., Koru, G., Eze, B., Gaudette, L., Neri, E., Rose, S., Howard, J., Gluck, J.: De-identification methods for open health data: the case of the Heritage Health Prize claims dataset. J. Med. Internet Res.\u00a014(1), 1\u201324 (2012)","journal-title":"J. Med. Internet Res."},{"key":"18_CR7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/009286150704100510","volume":"41","author":"A.M. Hochberg","year":"2007","unstructured":"Hochberg, A.M., Reisinger, S.J., Pearson, R.K., O\u2019Hara, D.J., Hall, K.: Using Data Mining to Predict Safety Actions From FDA Adverse Event Reporting System Data. Drug Information Journal\u00a041, 633\u2013643 (2007)","journal-title":"Drug Information Journal"},{"issue":"1","key":"18_CR8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1046\/j.1525-1497.2003.20130.x","volume":"18","author":"S.R.. Ahmad","year":"2003","unstructured":"Ahmad, S.R.: Adverse Drug Event Monitoring at the Food and Drug Administration. J. Gen. Intern. Med.\u00a018(1), 57\u201360 (2003)","journal-title":"J. Gen. Intern. Med."},{"key":"18_CR9","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1001\/archinte.165.12.1363","volume":"165","author":"D.K. Wysowski","year":"2005","unstructured":"Wysowski, D.K., Swartz, L.: Adverse Drug Event Surveillance and Drug Withdrawals in the United States, 1969-2002. Arch. Intern. Med.\u00a0165, 1363\u20131369 (2005)","journal-title":"Arch. Intern. Med."},{"key":"18_CR10","doi-asserted-by":"crossref","unstructured":"Hoblitzell, A., Mukhopadhyay, S., You, Q., et al.: Text mining for bone biology. In: HPDC 2010 (2010)","DOI":"10.1145\/1851476.1851552"},{"issue":"11","key":"18_CR11","first-page":"713","volume":"28","author":"M. Honeywell","year":"2003","unstructured":"Honeywell, M., Philips, S., Vo, K., et al.: Teriparatide for Osteoporosis: A Clinical Review. Drug Forecast\u00a028(11), 713\u2013716 (2003)","journal-title":"Drug Forecast"},{"issue":"9319","key":"18_CR12","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","volume":"359","author":"S.R. Cummings","year":"2002","unstructured":"Cummings, S.R., Melton, L.J.: Epidemiology and outcomes of osteoporotic fractures. Lancet 2002\u00a0359(9319), 1761\u20131767 (2002)","journal-title":"Lancet 2002"},{"key":"18_CR13","unstructured":"Carmona, R.H.: Bone Health and Osteoporosis: A Report of the U.S. Surgeon General (2004)"},{"issue":"1","key":"18_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/clpt.2011.83","volume":"90","author":"N.P. Tatonetti","year":"2011","unstructured":"Tatonetti, N.P., Denny, J.C., Murphy, S.N., Fernald, G.H., Krishnan, G., Castro, V., Yue, P., Tsau, P.S., Kohane, I., Roden, D.M., Altman, R.B.: Detecting Drug Interactions From Adverse\u2013Event Reports: Interaction Between Paroxetine and Pravastatin Increases Blood Glucose Levels. Clin. Pharmacol. Ther.\u00a090(1), 133\u2013142 (2011)","journal-title":"Clin. Pharmacol. Ther."},{"issue":"93","key":"18_CR15","first-page":"1","volume":"30","author":"K. Kadoyama","year":"2011","unstructured":"Kadoyama, K., Kuwahara, A., Yamamori, M., Brown, J.B., Sakaeda, T., Okuno, Y.: Hypersensitivity Reactions to Anticancer Agents: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS. Journal of Experimental & Clinical Cancer Research\u00a030(93), 1\u20136 (2011)","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"issue":"6","key":"18_CR16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.7150\/ijms.4549","volume":"9","author":"T. Tamura","year":"2012","unstructured":"Tamura, T., Sakaeda, T., Kadoyama, K., Okuno, Y.: Aspirin and Clopidogrel-associated Bleeding Complications: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS. International Journal of Medical Sciences\u00a09(6), 441\u2013446 (2012)","journal-title":"International Journal of Medical Sciences"},{"key":"18_CR17","first-page":"1","volume":"12","author":"P.K. Gandhi","year":"2012","unstructured":"Gandhi, P.K., Gentry, W.M., Bottorff, M.B.: Cardiovascular thromboembolic events associated with febuxostat: Investigation of cases from the FDA adverse event reporting system database. Seminars in Arthritis and Rheumatism\u00a012, 1\u20135 (2012)","journal-title":"Seminars in Arthritis and Rheumatism"},{"issue":"1","key":"18_CR18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.7150\/ijms.9.33","volume":"9","author":"K. Kadoyama","year":"2012","unstructured":"Kadoyama, K., Miki, I., Tamura, T., Brown, J.B., Sakaeda, T., Okuno, Y.: Adverse Event Profiles of 5-Fluorouracil and Capecitabine: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS, and Reproducibility of Clinical Observations. Int. J. Med. Sci.\u00a09(1), 33\u201339 (2012)","journal-title":"Int. J. Med. Sci."},{"issue":"6","key":"18_CR19","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1248\/bpb.35.967","volume":"35","author":"K. Kadoyama","year":"2012","unstructured":"Kadoyama, K., Sakaeda, T., Tamon, A., Okuno, Y.: Adverse event Profile of Tigecycline: Data Mining of the Public Version of the U.S. Food and Drug Administraion Adverse Event Reporting System. Biol. Pharm. Bull.\u00a035(6), 967\u2013970 (2012)","journal-title":"Biol. Pharm. Bull."},{"key":"18_CR20","volume-title":"Data mining: concepts and techniques","author":"J. Han","year":"2001","unstructured":"Han, J., Micheline, K.: Data mining: concepts and techniques. Morgan Kaufmann, San Francisco (2001)"},{"key":"18_CR21","unstructured":"Zhu, A., Li, J., Leong, T.: Automated Knowledge Extraction for Decision Model Construction: A Data Mining Approach. In: AMIA 2003 Symposium Proceedings, pp. 758\u2013762 (2003)"},{"key":"18_CR22","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10557-004-6226-y","volume":"18","author":"J. Kim","year":"2004","unstructured":"Kim, J., Washio, T., Yamagishi, M., Yasumura, Y., Nakatani, S., Hashimura, K., Hanatani, A., Komamura, K., Miyatake, K., Kitamura, S., Tomoike, H., Kitakaze, M.: A Novel Data Mining Approach to the Identification of Effective Drugs or Combinations for Targeted Endpoints:Application to Chronic Heart Failure as a New Form of Evidence-based Medicine. Cardiovascular Drugs and Therapy\u00a018, 483\u2013489 (2004)","journal-title":"Cardiovascular Drugs and Therapy"},{"key":"18_CR23","unstructured":"Drugbank, http:\/\/www.drugbank.ca (last access: January 02, 2013)"},{"key":"18_CR24","doi-asserted-by":"crossref","unstructured":"Hall, M., Frank, E., Holmes, G., Pfahringe, B., Reutemann, P., Witten, I.E.: The WEKA data mining software: an update. ACM SIGKDD Explorations Newsletter\u00a011(1) (2009)","DOI":"10.1145\/1656274.1656278"},{"key":"18_CR25","unstructured":"WEKA: Weka 3: Data Mining Software in Java, http:\/\/www.cs.waikato.ac.nz\/ml\/weka (last access: May 02, 2012)"},{"key":"18_CR26","series-title":"LNAI","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/3-540-44794-6_35","volume-title":"Principles of Data Mining and Knowledge Discovery","author":"T. Scheffer","year":"2001","unstructured":"Scheffer, T.: Finding Association Rules That Trade Support Optimally against Confidence. In: Siebes, A., De Raedt, L. (eds.) PKDD 2001. LNCS (LNAI), vol.\u00a02168, pp. 424\u2013435. Springer, Heidelberg (2001)"},{"key":"18_CR27","first-page":"573","volume-title":"IEEE COMPSAC 36th International Conference on Computer Software and Application","author":"A. Holzinger","year":"2012","unstructured":"Holzinger, A., Simonic, K.M., Yildirim, P.: Disease-disease relationships for rheumatic diseases Web-based biomedical textmining and knowledge discovery to assist medical decision making. In: IEEE COMPSAC 36th International Conference on Computer Software and Application, pp. 573\u2013580. IEEE, New York (2012)"},{"key":"18_CR28","series-title":"ISRL","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-3-642-37688-7_7","volume-title":"Quality Issues in the Management of Web Information","author":"A. Holzinger","year":"2013","unstructured":"Holzinger, A., Yildirim, P., Geier, M., Simonic, K.-M.: Quality-based knowledge discovery from medical text on the Web Example of computational methods in Web intelligence. In: Pasi, G., Bordogna, G., Jain, L.C. (eds.) Qual. Issues in the Management of Web Information. ISRL, vol.\u00a050, pp. 145\u2013158. Springer, Heidelberg (2013)"},{"key":"18_CR29","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/978-3-642-32395-9_13","volume-title":"Information Technology in Bio- and Medical Informatics","author":"A. Holzinger","year":"2012","unstructured":"Holzinger, A., Scherer, R., Seeber, M., Wagner, J., M\u00fcller-Putz, G.: Computational Sensemaking on Examples of Knowledge Discovery from Neuroscience Data: Towards Enhancing Stroke Rehabilitation. In: B\u00f6hm, C., Khuri, S., Lhotsk\u00e1, L., Renda, M.E. (eds.) ITBAM 2012. LNCS, vol.\u00a07451, pp. 166\u2013168. Springer, Heidelberg (2012)"}],"container-title":["Lecture Notes in Computer Science","Human-Computer Interaction and Knowledge Discovery in Complex, Unstructured, Big Data"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-39146-0_18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T07:23:22Z","timestamp":1563261802000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-39146-0_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"ISBN":["9783642391453","9783642391460"],"references-count":29,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-39146-0_18","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}