{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:30:13Z","timestamp":1790836213155,"version":"4.1.0"},"publisher-location":"Berlin, Heidelberg","reference-count":167,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642415876","type":"print"},{"value":"9783642415883","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-3-642-41588-3_4","type":"book-chapter","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T08:35:51Z","timestamp":1397550951000},"page":"51-89","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["The Role of Non-pore-Forming \u03b2 Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels"],"prefix":"10.1007","author":[{"given":"Jeffrey D.","family":"Calhoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L.","family":"Isom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"issue":"1","key":"4_CR1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tcm.2005.01.001","volume":"15","author":"H Abriel","year":"2005","unstructured":"Abriel H, Kass RS (2005) Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends Cardiovasc Med 15(1):35\u201340","journal-title":"Trends Cardiovasc Med"},{"issue":"47","key":"4_CR2","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1038\/sj.onc.1208067","volume":"23","author":"K Adachi","year":"2004","unstructured":"Adachi K, Toyota M, Sasaki Y, Yamashita T, Ishida S, Ohe-Toyota M, Maruyama R, Hinoda Y, Saito T, Imai K, Kudo R, Tokino T (2004) Identification of SCN3B as a novel p53-inducible proapoptotic gene. Oncogene 23(47):7791\u20137798","journal-title":"Oncogene"},{"issue":"7","key":"4_CR3","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1523\/JNEUROSCI.4531-08.2009","volume":"29","author":"TK Aman","year":"2009","unstructured":"Aman TK, Grieco-Calub TM, Chen C, Rusconi R, Slat EA, Isom LL, Raman IM (2009) Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels. J Neurosci 29(7):2027\u20132042","journal-title":"J Neurosci"},{"issue":"3","key":"4_CR4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/CIRCULATIONAHA.106.658021","volume":"115","author":"M Arnestad","year":"2007","unstructured":"Arnestad M, Crotti L, Rognum TO, Insolia R, Pedrazzini M, Ferrandi C, Vege A, Wang DW, Rhodes TE, George AL Jr, Schwartz PJ (2007) Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation 115(3):361\u2013367","journal-title":"Circulation"},{"issue":"5","key":"4_CR5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00401-003-0677-2","volume":"105","author":"E Aronica","year":"2003","unstructured":"Aronica E, Troost D, Rozemuller AJ, Yankaya B, Jansen GH, Isom LL, Gorter JA (2003) Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies. Acta Neuropathol 105(5):515\u2013523","journal-title":"Acta Neuropathol"},{"issue":"6","key":"4_CR6","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1212\/01.WNL.0000080362.55784.1C","volume":"61","author":"D Audenaert","year":"2003","unstructured":"Audenaert D, Claes L, Ceulemans B, Lofgren A, Van Broeckhoven C, De Jonghe P (2003) A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy. Neurology 61(6):854\u2013856","journal-title":"Neurology"},{"issue":"6","key":"4_CR7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0896-6273(88)90176-6","volume":"1","author":"VJ Auld","year":"1988","unstructured":"Auld VJ, Goldin AL, Krafte DS, Marshall J, Dunn JM, Catterall WA, Lester HA, Davidson N, Dunn RJ (1988) A rat brain Na+ channel alpha subunit with novel gating properties. Neuron 1(6):449\u2013461","journal-title":"Neuron"},{"issue":"27","key":"4_CR8","doi-asserted-by":"crossref","first-page":"12357","DOI":"10.1073\/pnas.1005633107","volume":"107","author":"JS Bant","year":"2010","unstructured":"Bant JS, Raman IM (2010) Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neurons. Proc Natl Acad Sci U S A 107(27):12357\u201312362","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"4_CR9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neuron.2005.01.006","volume":"45","author":"BP Bean","year":"2005","unstructured":"Bean BP (2005) The molecular machinery of resurgent sodium current revealed. Neuron 45(2):185\u2013187","journal-title":"Neuron"},{"issue":"5","key":"4_CR10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4161\/chan.21910","volume":"6","author":"WJ Brackenbury","year":"2012","unstructured":"Brackenbury WJ (2012) Voltage-gated sodium channels and metastatic disease. Channels 6(5):352\u2013361","journal-title":"Channels"},{"issue":"5","key":"4_CR11","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1073\/pnas.0909434107","volume":"107","author":"WJ Brackenbury","year":"2010","unstructured":"Brackenbury WJ, Calhoun JD, Chen C, Miyazaki H, Nukina N, Oyama F, Ranscht B, Isom LL (2010) Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proc Natl Acad Sci U S A 107(5):2283\u20132288","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"4_CR12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10549-006-9281-1","volume":"101","author":"WJ Brackenbury","year":"2007","unstructured":"Brackenbury WJ, Chioni AM, Diss JK, Djamgoz MB (2007) The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat 101(2):149\u2013160","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"4_CR13","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1523\/JNEUROSCI.5446-07.2008","volume":"28","author":"WJ Brackenbury","year":"2008","unstructured":"Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, Ranscht B, Isom LL (2008) Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci 28(12):3246\u20133256","journal-title":"J Neurosci"},{"issue":"9","key":"4_CR14","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1517\/14728222.12.9.1191","volume":"12","author":"WJ Brackenbury","year":"2008","unstructured":"Brackenbury WJ, Isom LL (2008) Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert Opin Ther Targets 12(9):1191\u20131203","journal-title":"Expert Opin Ther Targets"},{"key":"4_CR15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphar.2011.00053","volume":"2","author":"WJ Brackenbury","year":"2011","unstructured":"Brackenbury WJ, Isom LL (2011) Na channel beta subunits: overachievers of the ion channel family. Front Pharmacol 2:53","journal-title":"Front Pharmacol"},{"issue":"3","key":"4_CR16","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1073\/pnas.1208767110","volume":"110","author":"WJ Brackenbury","year":"2013","unstructured":"Brackenbury WJ, Yuan Y, O\u2019Malley HA, Parent JM, Isom LL (2013) Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proc Natl Acad Sci U S A 110(3):1089\u20131094","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"4_CR17","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1161\/01.RES.0000074908.17214.FD","volume":"92","author":"F Brette","year":"2003","unstructured":"Brette F, Orchard C (2003) T-tubule function in mammalian cardiac myocytes. Circ Res 92(11):1182\u20131192","journal-title":"Circ Res"},{"issue":"14","key":"4_CR18","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1523\/JNEUROSCI.4051-12.2013","volume":"33","author":"SA Buffington","year":"2013","unstructured":"Buffington SA, Rasband MN (2013) Na+ channel-dependent recruitment of navbeta4 to axon initial segments and nodes of ranvier. J Neurosci 33(14):6191\u20136202","journal-title":"J Neurosci"},{"issue":"4","key":"4_CR19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ng0895-461","volume":"10","author":"DL Burgess","year":"1995","unstructured":"Burgess DL, Kohrman DC, Galt J, Plummer NW, Jones JM, Spear B, Meisler MH (1995) Mutation of a new sodium channel gene, Scn8a, in the mouse mutant \u2018motor endplate disease\u2019. Nat Genet 10(4):461\u2013465","journal-title":"Nat Genet"},{"issue":"10","key":"4_CR20","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/01.wnr.0000134927.02776.ae","volume":"15","author":"MA Casula","year":"2004","unstructured":"Casula MA, Facer P, Powell AJ, Kinghorn IJ, Plumpton C, Tate SN, Bountra C, Birch R, Anand P (2004) Expression of the sodium channel beta3 subunit in injured human sensory neurons. Neuroreport 15(10):1629\u20131632","journal-title":"Neuroreport"},{"issue":"1","key":"4_CR21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","volume":"26","author":"WA Catterall","year":"2000","unstructured":"Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26(1):13\u201325","journal-title":"Neuron"},{"issue":"32","key":"4_CR22","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1021\/bi200942y","volume":"50","author":"K Charalambous","year":"2011","unstructured":"Charalambous K, Wallace BA (2011) NaChBac: the long lost sodium channel ancestor. Biochemistry 50(32):6742\u20136752","journal-title":"Biochemistry"},{"issue":"26","key":"4_CR23","doi-asserted-by":"crossref","first-page":"17072","DOI":"10.1073\/pnas.212638099","volume":"99","author":"C Chen","year":"2002","unstructured":"Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ 3rd, Kazen-Gillespie KA, Kazarinova-Noyes K, Shrager P, Saunders TL, Macdonald RL, Ransom BR, Scheuer T, Catterall WA, Isom LL (2002) Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A 99(26):17072\u201317077","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"46","key":"4_CR24","doi-asserted-by":"crossref","first-page":"39061","DOI":"10.1074\/jbc.M112.397646","volume":"287","author":"C Chen","year":"2012","unstructured":"Chen C, Calhoun JD, Zhang Y, Lopez-Santiago L, Zhou N, Davis TH, Salzer JL, Isom LL (2012) Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 Subunits. J Biol Chem 287(46):39061\u201339069","journal-title":"J Biol Chem"},{"issue":"16","key":"4_CR25","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1523\/JNEUROSCI.4139-03.2004","volume":"24","author":"C Chen","year":"2004","unstructured":"Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O\u2019Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL (2004) Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 24(16):4030\u20134042","journal-title":"J Neurosci"},{"issue":"4","key":"4_CR26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.mcn.2008.05.009","volume":"38","author":"Y Chen","year":"2008","unstructured":"Chen Y, Yu FH, Sharp EM, Beacham D, Scheuer T, Catterall WA (2008) Functional properties and differential neuromodulation of Na(v)1.6 channels. Mol Cell Neurosci 38(4):607\u2013615","journal-title":"Mol Cell Neurosci"},{"issue":"5","key":"4_CR27","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.biocel.2008.11.001","volume":"41","author":"AM Chioni","year":"2009","unstructured":"Chioni AM, Brackenbury WJ, Calhoun JD, Isom LL, Djamgoz MB (2009) A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit. Int J Biochem Cell Biol 41(5):1216\u20131227","journal-title":"Int J Biochem Cell Biol"},{"key":"4_CR28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2148-7-113","volume":"7","author":"SS Chopra","year":"2007","unstructured":"Chopra SS, Watanabe H, Zhong TP, Roden DM (2007) Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates. BMC Evol Biol 7:113","journal-title":"BMC Evol Biol"},{"issue":"9791","key":"4_CR29","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0140-6736(11)60756-3","volume":"378","author":"S Cirak","year":"2011","unstructured":"Cirak S, Arechavala-Gomeza V, Guglieri M, Feng L, Torelli S, Anthony K, Abbs S, Garralda ME, Bourke J, Wells DJ, Dickson G, Wood MJ, Wilton SD, Straub V, Kole R, Shrewsbury SB, Sewry C, Morgan JE, Bushby K, Muntoni F (2011) Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study. Lancet 378(9791):595\u2013605","journal-title":"Lancet"},{"issue":"6","key":"4_CR30","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1086\/320609","volume":"68","author":"L Claes","year":"2001","unstructured":"Claes L, Del-Favero J, Ceulemans B, Lagae L, Van Broeckhoven C, De Jonghe P (2001) De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of infancy. Am J Hum Genet 68(6):1327\u20131332","journal-title":"Am J Hum Genet"},{"issue":"49","key":"4_CR31","doi-asserted-by":"crossref","first-page":"51424","DOI":"10.1074\/jbc.M410830200","volume":"279","author":"TH Davis","year":"2004","unstructured":"Davis TH, Chen C, Isom LL (2004) Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons. J Biol Chem 279(49):51424\u201351432","journal-title":"J Biol Chem"},{"issue":"1","key":"4_CR32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.hrthm.2004.02.003","volume":"1","author":"M Delmar","year":"2004","unstructured":"Delmar M (2004) The intercalated disk as a single functional unit. Heart Rhythm 1(1):12\u201313","journal-title":"Heart Rhythm"},{"issue":"3","key":"4_CR33","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.yjmcc.2008.05.001","volume":"45","author":"I Deschenes","year":"2008","unstructured":"Deschenes I, Armoundas AA, Jones SP, Tomaselli GF (2008) Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol 45(3):336\u2013346","journal-title":"J Mol Cell Cardiol"},{"issue":"1\u20133","key":"4_CR34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0014-5793(02)03296-9","volume":"528","author":"I Deschenes","year":"2002","unstructured":"Deschenes I, Tomaselli GF (2002) Modulation of Kv4.3 current by accessory subunits. FEBS Lett 528(1\u20133):183\u2013188","journal-title":"FEBS Lett"},{"issue":"9","key":"4_CR35","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1161\/01.CIR.103.9.1303","volume":"103","author":"J Dhar Malhotra","year":"2001","unstructured":"Dhar Malhotra J, Chen C, Rivolta I, Abriel H, Malhotra R, Mattei LN, Brosius FC, Kass RS, Isom LL (2001) Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. Circulation 103(9):1303\u20131310","journal-title":"Circulation"},{"issue":"2","key":"4_CR36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2010.08.077","volume":"486","author":"SD Dib-Hajj","year":"2010","unstructured":"Dib-Hajj SD, Waxman SG (2010) Isoform-specific and pan-channel partners regulate trafficking and plasma membrane stability; and alter sodium channel gating properties. Neurosci Lett 486(2):84\u201391","journal-title":"Neurosci Lett"},{"issue":"4","key":"4_CR37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.pcan.4501012","volume":"11","author":"JK Diss","year":"2008","unstructured":"Diss JK, Fraser SP, Walker MM, Patel A, Latchman DS, Djamgoz MB (2008) Beta-subunits of voltage-gated sodium channels in human prostate cancer: quantitative in vitro and in vivo analyses of mRNA expression. Prostate Cancer Prostatic Dis 11(4):325\u2013333","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"44","key":"4_CR38","doi-asserted-by":"crossref","first-page":"36639","DOI":"10.1074\/jbc.M112.393637","volume":"287","author":"PD Eckford","year":"2012","unstructured":"Eckford PD, Li C, Ramjeesingh M, Bear CE (2012) Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner. J Biol Chem 287(44):36639\u201336649","journal-title":"J Biol Chem"},{"issue":"2","key":"4_CR39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0306-4522(03)00168-4","volume":"119","author":"RK Ellerkmann","year":"2003","unstructured":"Ellerkmann RK, Remy S, Chen J, Sochivko D, Elger CE, Urban BW, Becker A, Beck H (2003) Molecular and functional changes in voltage-dependent Na(+) channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience 119(2):323\u2013333","journal-title":"Neuroscience"},{"issue":"9","key":"4_CR40","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1111\/j.1528-1167.2010.02640.x","volume":"51","author":"A Escayg","year":"2010","unstructured":"Escayg A, Goldin AL (2010) Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia 51(9):1650\u20131658","journal-title":"Epilepsia"},{"issue":"4","key":"4_CR41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/74159","volume":"24","author":"A Escayg","year":"2000","unstructured":"Escayg A, MacDonald BT, Meisler MH, Baulac S, Huberfeld G, An-Gourfinkel I, Brice A, LeGuern E, Moulard B, Chaigne D, Buresi C, Malafosse A (2000) Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2. Nat Genet 24(4):343\u2013345","journal-title":"Nat Genet"},{"key":"4_CR42","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1471-2164-8-226","volume":"8","author":"AJ Fein","year":"2007","unstructured":"Fein AJ, Meadows LS, Chen C, Slat EA, Isom LL (2007) Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant. BMC Genom 8:226","journal-title":"BMC Genom"},{"issue":"47","key":"4_CR43","doi-asserted-by":"crossref","first-page":"12510","DOI":"10.1523\/JNEUROSCI.4329-08.2008","volume":"28","author":"AJ Fein","year":"2008","unstructured":"Fein AJ, Wright MA, Slat EA, Ribera AB, Isom LL (2008) scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity. J Neurosci 28(47):12510\u201312522","journal-title":"J Neurosci"},{"issue":"5","key":"4_CR44","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1468-1331.2010.03216.x","volume":"18","author":"N Fendri-Kriaa","year":"2011","unstructured":"Fendri-Kriaa N, Kammoun F, Salem IH, Kifagi C, Mkaouar-Rebai E, Hsairi I, Rebai A, Triki C, Fakhfakh F (2011) New mutation c.374C>T and a putative disease-associated haplotype within SCN1B gene in Tunisian families with febrile seizures. Eur J Neurol 18(5):695\u2013702","journal-title":"Eur J Neurol"},{"issue":"2","key":"4_CR45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1083\/jcb.122.2.451","volume":"122","author":"MT Filbin","year":"1993","unstructured":"Filbin MT, Tennekoon GI (1993) Homophilic adhesion of the myelin P0 protein requires glycosylation of both molecules in the homophilic pair. J Cell Biol 122(2):451\u2013459","journal-title":"J Cell Biol"},{"issue":"Pt 5","key":"4_CR46","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1242\/jeb.205.5.575","volume":"205","author":"AL Goldin","year":"2002","unstructured":"Goldin AL (2002) Evolution of voltage-gated Na(+) channels. J Exp Biol 205(Pt 5):575\u2013584","journal-title":"J Exp Biol"},{"issue":"19","key":"4_CR47","doi-asserted-by":"crossref","first-page":"7503","DOI":"10.1073\/pnas.83.19.7503","volume":"83","author":"AL Goldin","year":"1986","unstructured":"Goldin AL, Snutch T, Lubbert H, Dowsett A, Marshall J, Auld V, Downey W, Fritz LC, Lester HA, Dunn R et al (1986) Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc Natl Acad Sci U S A 83(19):7503\u20137507","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"4_CR48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuron.2004.12.035","volume":"45","author":"TM Grieco","year":"2005","unstructured":"Grieco TM, Malhotra JD, Chen C, Isom LL, Raman IM (2005) Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron 45(2):233\u2013244","journal-title":"Neuron"},{"issue":"1","key":"4_CR49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1748-1716.2009.02048.x","volume":"198","author":"P Hakim","year":"2010","unstructured":"Hakim P, Brice N, Thresher R, Lawrence J, Zhang Y, Jackson AP, Grace AA, Huang CL (2010) Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties. Acta Physiol 198(1):47\u201359","journal-title":"Acta Physiol"},{"issue":"2\u20133","key":"4_CR50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pbiomolbio.2009.01.005","volume":"98","author":"P Hakim","year":"2008","unstructured":"Hakim P, Gurung IS, Pedersen TH, Thresher R, Brice N, Lawrence J, Grace AA, Huang CL (2008) Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. Prog Biophys Mol Biol 98(2\u20133):251\u2013266","journal-title":"Prog Biophys Mol Biol"},{"issue":"3","key":"4_CR51","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S0021-9258(17)43460-0","volume":"259","author":"RP Hartshorne","year":"1984","unstructured":"Hartshorne RP, Catterall WA (1984) The sodium channel from rat brain. Purification and subunit composition. J Biol Chem 259(3):1667\u20131675","journal-title":"J Biol Chem"},{"issue":"23","key":"4_CR52","doi-asserted-by":"crossref","first-page":"13888","DOI":"10.1016\/S0021-9258(19)45312-X","volume":"257","author":"RP Hartshorne","year":"1982","unstructured":"Hartshorne RP, Messner DJ, Coppersmith JC, Catterall WA (1982) The saxitoxin receptor of the sodium channel from rat brain. Evidence for two nonidentical beta subunits. J Biol Chem 257(23):13888\u201313891","journal-title":"J Biol Chem"},{"issue":"6","key":"4_CR53","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1074\/jbc.M109.057455","volume":"285","author":"K Irie","year":"2010","unstructured":"Irie K, Kitagawa K, Nagura H, Imai T, Shimomura T, Fujiyoshi Y (2010) Comparative study of the gating motif and C-type inactivation in prokaryotic voltage-gated sodium channels. J Biol Chem 285(6):3685\u20133694","journal-title":"J Biol Chem"},{"issue":"4","key":"4_CR54","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1253\/circj.CJ-12-0995","volume":"77","author":"T Ishikawa","year":"2013","unstructured":"Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A (2013) Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J 77(4):959\u2013967","journal-title":"Circ J"},{"issue":"1","key":"4_CR55","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/107385840100700108","volume":"7","author":"LL Isom","year":"2001","unstructured":"Isom LL (2001) Sodium channel beta subunits: anything but auxiliary. Neuroscientist 7(1):42\u201354","journal-title":"Neuroscientist"},{"issue":"6","key":"4_CR56","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0896-6273(94)90436-7","volume":"12","author":"LL Isom","year":"1994","unstructured":"Isom LL, De Jongh KS, Catterall WA (1994) Auxiliary subunits of voltage-gated ion channels. Neuron 12(6):1183\u20131194","journal-title":"Neuron"},{"issue":"5058","key":"4_CR57","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.256.5058.839","volume":"256","author":"LL Isom","year":"1992","unstructured":"Isom LL, De Jongh KS, Patton DE, Reber BF, Offord J, Charbonneau H, Walsh K, Goldin AL, Catterall WA (1992) Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science 256(5058):839\u2013842","journal-title":"Science"},{"issue":"3","key":"4_CR58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0092-8674(95)90121-3","volume":"83","author":"LL Isom","year":"1995","unstructured":"Isom LL, Ragsdale DS, De Jongh KS, Westenbroek RE, Reber BF, Scheuer T, Catterall WA (1995a) Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif. Cell 83(3):433\u2013442","journal-title":"Cell"},{"issue":"7","key":"4_CR59","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1074\/jbc.270.7.3306","volume":"270","author":"LL Isom","year":"1995","unstructured":"Isom LL, Scheuer T, Brownstein AB, Ragsdale DS, Murphy BJ, Catterall WA (1995b) Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. J Biol Chem 270(7):3306\u20133312","journal-title":"J Biol Chem"},{"issue":"29","key":"4_CR60","doi-asserted-by":"crossref","first-page":"10566","DOI":"10.1073\/pnas.0402692101","volume":"101","author":"M Ito","year":"2004","unstructured":"Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA (2004) The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. Proc Natl Acad Sci U S A 101(29):10566\u201310571","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"36","key":"4_CR61","doi-asserted-by":"crossref","first-page":"25875","DOI":"10.1074\/jbc.M605060200","volume":"281","author":"D Johnson","year":"2006","unstructured":"Johnson D, Bennett ES (2006) Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating. J Biol Chem 281(36):25875\u201325881","journal-title":"J Biol Chem"},{"issue":"43","key":"4_CR62","doi-asserted-by":"crossref","first-page":"44303","DOI":"10.1074\/jbc.M408900200","volume":"279","author":"D Johnson","year":"2004","unstructured":"Johnson D, Montpetit ML, Stocker PJ, Bennett ES (2004) The sialic acid component of the beta1 subunit modulates voltage-gated sodium channel function. J Biol Chem 279(43):44303\u201344310","journal-title":"J Biol Chem"},{"issue":"2","key":"4_CR63","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0169-328X(90)90087-T","volume":"7","author":"RH Joho","year":"1990","unstructured":"Joho RH, Moorman JR, VanDongen AM, Kirsch GE, Silberberg H, Schuster G, Brown AM (1990) Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes. Brain Res Mol Brain Res 7(2):105\u2013113","journal-title":"Brain Res Mol Brain Res"},{"issue":"1","key":"4_CR64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0896-6273(01)00266-5","volume":"30","author":"MR Kaplan","year":"2001","unstructured":"Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA (2001) Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron 30(1):105\u2013119","journal-title":"Neuron"},{"key":"4_CR65","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2013.05.006","volume":"61","author":"SG Kaufmann","year":"2013","unstructured":"Kaufmann SG, Westenbroek RE, Maass AH, Lange V, Renner A, Wischmeyer E, Bonz A, Muck J, Ertl G, Catterall WA, Scheuer T, Maier SK (2013) Distribution and function of sodium channel subtypes in human atrial myocardium. J Mol Cell Cardiol 61:133\u2013141","journal-title":"J Mol Cell Cardiol"},{"issue":"19","key":"4_CR66","doi-asserted-by":"crossref","first-page":"7517","DOI":"10.1523\/JNEUROSCI.21-19-07517.2001","volume":"21","author":"K Kazarinova-Noyes","year":"2001","unstructured":"Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC (2001) Contactin associates with Na+ channels and increases their functional expression. J Neurosci 21(19):7517\u20137525","journal-title":"J Neurosci"},{"issue":"2","key":"4_CR67","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1074\/jbc.275.2.1079","volume":"275","author":"KA Kazen-Gillespie","year":"2000","unstructured":"Kazen-Gillespie KA, Ragsdale DS, D\u2019Andrea MR, Mattei LN, Rogers KE, Isom LL (2000) Cloning, localization, and functional expression of sodium channel beta1A subunits. J Biol Chem 275(2):1079\u20131088","journal-title":"J Biol Chem"},{"issue":"7","key":"4_CR68","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ncb1602","volume":"9","author":"DY Kim","year":"2007","unstructured":"Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM (2007) BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol 9(7):755\u2013764","journal-title":"Nat Cell Biol"},{"issue":"24","key":"4_CR69","doi-asserted-by":"crossref","first-page":"23251","DOI":"10.1074\/jbc.M412938200","volume":"280","author":"DY Kim","year":"2005","unstructured":"Kim DY, Ingano LA, Carey BW, Pettingell WH, Kovacs DM (2005) Presenilin\/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration. J Biol Chem 280(24):23251\u201323261","journal-title":"J Biol Chem"},{"issue":"4","key":"4_CR70","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00424-004-1348-4","volume":"449","author":"SH Ko","year":"2005","unstructured":"Ko SH, Lenkowski PW, Lee HC, Mounsey JP, Patel MK (2005) Modulation of Na(v)1.5 by beta1\u2013 and beta3-subunit co-expression in mammalian cells. Pflugers Arch 449(4):403\u2013412","journal-title":"Pflugers Arch"},{"issue":"10","key":"4_CR71","doi-asserted-by":"crossref","first-page":"9532","DOI":"10.1074\/jbc.M313100200","volume":"279","author":"R Koishi","year":"2004","unstructured":"Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE (2004) A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem 279(10):9532\u20139538","journal-title":"J Biol Chem"},{"issue":"4","key":"4_CR72","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1085\/jgp.96.4.689","volume":"96","author":"DS Krafte","year":"1990","unstructured":"Krafte DS, Goldin AL, Auld VJ, Dunn RJ, Davidson N, Lester HA (1990) Inactivation of cloned Na channels expressed in Xenopus oocytes. J Gen Physiol 96(4):689\u2013706","journal-title":"J Gen Physiol"},{"issue":"41","key":"4_CR73","doi-asserted-by":"crossref","first-page":"29042","DOI":"10.1074\/jbc.274.41.29042","volume":"274","author":"EM Kramer","year":"1999","unstructured":"Kramer EM, Klein C, Koch T, Boytinck M, Trotter J (1999) Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination. J Biol Chem 274(41):29042\u201329049","journal-title":"J Biol Chem"},{"issue":"1\u20133","key":"4_CR74","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(03)01595-4","volume":"467","author":"PW Lenkowski","year":"2003","unstructured":"Lenkowski PW, Shah BS, Dinn AE, Lee K, Patel MK (2003) Lidocaine block of neonatal Nav1.3 is differentially modulated by co-expression of beta1 and beta3 subunits. Eur J Pharmacol 467(1\u20133):23\u201330","journal-title":"Eur J Pharmacol"},{"key":"4_CR75","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3892\/ijmm.2013.1355","volume":"32","author":"RG Li","year":"2013","unstructured":"Li RG, Wang Q, Xu YJ, Zhang M, Qu XK, Liu X, Fang WY, Yang YQ (2013) Mutations of the SCN4B-encoded sodium channel beta4 subunit in familial atrial fibrillation. Int J Mol Med 32:144\u2013150","journal-title":"Int J Mol Med"},{"key":"4_CR76","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/1471-2148-11-337","volume":"11","author":"J Li","year":"2011","unstructured":"Li J, Waterhouse RM, Zdobnov EM (2011) A remarkably stable TipE gene cluster: evolution of insect para sodium channel auxiliary subunits. BMC Evol Biol 11:337","journal-title":"BMC Evol Biol"},{"issue":"15","key":"4_CR77","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1097\/00001756-200210280-00015","volume":"13","author":"AC Lo","year":"2002","unstructured":"Lo AC, Black JA, Waxman SG (2002) Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis. Neuroreport 13(15):1909\u20131912","journal-title":"Neuroreport"},{"issue":"5","key":"4_CR78","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1152\/jn.00434.2003","volume":"90","author":"AC Lo","year":"2003","unstructured":"Lo AC, Saab CY, Black JA, Waxman SG (2003) Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo. J Neurophysiol 90(5):3566\u20133571","journal-title":"J Neurophysiol"},{"issue":"26","key":"4_CR79","doi-asserted-by":"crossref","first-page":"22913","DOI":"10.1074\/jbc.M111.242370","volume":"286","author":"LF Lopez-Santiago","year":"2011","unstructured":"Lopez-Santiago LF, Brackenbury WJ, Chen C, Isom LL (2011) Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo. J Biol Chem 286(26):22913\u201322923","journal-title":"J Biol Chem"},{"issue":"5","key":"4_CR80","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.yjmcc.2007.07.062","volume":"43","author":"LF Lopez-Santiago","year":"2007","unstructured":"Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol 43(5):636\u2013647","journal-title":"J Mol Cell Cardiol"},{"issue":"30","key":"4_CR81","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1523\/JNEUROSCI.2211-06.2006","volume":"26","author":"LF Lopez-Santiago","year":"2006","unstructured":"Lopez-Santiago LF, Pertin M, Morisod X, Chen C, Hong S, Wiley J, Decosterd I, Isom LL (2006) Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J Neurosci 26(30):7984\u20137994","journal-title":"J Neurosci"},{"issue":"5","key":"4_CR82","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nrm2679","volume":"10","author":"LA Lowery","year":"2009","unstructured":"Lowery LA, Van Vactor D (2009) The trip of the tip: understanding the growth cone machinery. Nat Rev Mol Cell Biol 10(5):332\u2013343","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"4_CR83","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.eplepsyres.2005.03.003","volume":"64","author":"PT Lucas","year":"2005","unstructured":"Lucas PT, Meadows LS, Nicholls J, Ragsdale DS (2005) An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin. Epilepsy Res 64(3):77\u201384","journal-title":"Epilepsy Res"},{"issue":"11","key":"4_CR84","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/01.CIR.0000121421.61896.24","volume":"109","author":"SK Maier","year":"2004","unstructured":"Maier SK, Westenbroek RE, McCormick KA, Curtis R, Scheuer T, Catterall WA (2004) Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart. Circulation 109(11):1421\u20131427","journal-title":"Circulation"},{"issue":"15","key":"4_CR85","doi-asserted-by":"crossref","first-page":"11383","DOI":"10.1074\/jbc.275.15.11383","volume":"275","author":"JD Malhotra","year":"2000","unstructured":"Malhotra JD, Kazen-Gillespie K, Hortsch M, Isom LL (2000) Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell\u2013cell contact. J Biol Chem 275(15):11383\u201311388","journal-title":"J Biol Chem"},{"issue":"29","key":"4_CR86","doi-asserted-by":"crossref","first-page":"26681","DOI":"10.1074\/jbc.M202354200","volume":"277","author":"JD Malhotra","year":"2002","unstructured":"Malhotra JD, Koopmann MC, Kazen-Gillespie KA, Fettman N, Hortsch M, Isom LL (2002) Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin. J Biol Chem 277(29):26681\u201326688","journal-title":"J Biol Chem"},{"issue":"39","key":"4_CR87","doi-asserted-by":"crossref","first-page":"40748","DOI":"10.1074\/jbc.M407243200","volume":"279","author":"JD Malhotra","year":"2004","unstructured":"Malhotra JD, Thyagarajan V, Chen C, Isom LL (2004) Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. J Biol Chem 279(39):40748\u201340754","journal-title":"J Biol Chem"},{"issue":"17","key":"4_CR88","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1523\/JNEUROSCI.6450-11.2012","volume":"32","author":"C Marionneau","year":"2012","unstructured":"Marionneau C, Carrasquillo Y, Norris AJ, Townsend RR, Isom LL, Link AJ, Nerbonne JM (2012) The sodium channel accessory subunit Navbeta1 regulates neuronal excitability through modulation of repolarizing voltage-gated K(+) channels. J Neurosci 32(17):5716\u20135727","journal-title":"J Neurosci"},{"issue":"7","key":"4_CR89","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1074\/jbc.273.7.3954","volume":"273","author":"KA McCormick","year":"1998","unstructured":"McCormick KA, Isom LL, Ragsdale D, Smith D, Scheuer T, Catterall WA (1998) Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit. J Biol Chem 273(7):3954\u20133962","journal-title":"J Biol Chem"},{"issue":"3","key":"4_CR90","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neulet.2009.07.020","volume":"462","author":"DP McEwen","year":"2009","unstructured":"McEwen DP, Chen C, Meadows LS, Lopez-Santiago L, Isom LL (2009) The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin. Neurosci Lett 462(3):272\u2013275","journal-title":"Neurosci Lett"},{"issue":"50","key":"4_CR91","doi-asserted-by":"crossref","first-page":"52744","DOI":"10.1074\/jbc.M405990200","volume":"279","author":"DP McEwen","year":"2004","unstructured":"McEwen DP, Isom LL (2004) Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules. J Biol Chem 279(50):52744\u201352752","journal-title":"J Biol Chem"},{"issue":"16","key":"4_CR92","doi-asserted-by":"crossref","first-page":"16044","DOI":"10.1074\/jbc.M400856200","volume":"279","author":"DP McEwen","year":"2004","unstructured":"McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL (2004) Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. J Biol Chem 279(16):16044\u201316049","journal-title":"J Biol Chem"},{"issue":"3","key":"4_CR93","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0306-4522(02)00242-7","volume":"114","author":"LS Meadows","year":"2002","unstructured":"Meadows LS, Chen YH, Powell AJ, Clare JJ, Ragsdale DS (2002a) Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits. Neuroscience 114(3):745\u2013753","journal-title":"Neuroscience"},{"issue":"24","key":"4_CR94","doi-asserted-by":"crossref","first-page":"10699","DOI":"10.1523\/JNEUROSCI.22-24-10699.2002","volume":"22","author":"LS Meadows","year":"2002","unstructured":"Meadows LS, Malhotra J, Loukas A, Thyagarajan V, Kazen-Gillespie KA, Koopman MC, Kriegler S, Isom LL, Ragsdale DS (2002b) Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. J Neurosci 22(24):10699\u201310709","journal-title":"J Neurosci"},{"issue":"6","key":"4_CR95","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1046\/j.1471-4159.2001.00192.x","volume":"76","author":"L Meadows","year":"2001","unstructured":"Meadows L, Malhotra JD, Stetzer A, Isom LL, Ragsdale DS (2001) The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit. J Neurochem 76(6):1871\u20131878","journal-title":"J Neurochem"},{"issue":"2","key":"4_CR96","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/CIRCULATIONAHA.106.659086","volume":"116","author":"A Medeiros-Domingo","year":"2007","unstructured":"Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusie-Luna MT, Makielski JC, Ackerman MJ (2007) SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. Circulation 116(2):134\u2013142","journal-title":"Circulation"},{"issue":"8","key":"4_CR97","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1172\/JCI25466","volume":"115","author":"MH Meisler","year":"2005","unstructured":"Meisler MH, Kearney JA (2005) Sodium channel mutations in epilepsy and other neurological disorders. J Clin Investig 115(8):2010\u20132017","journal-title":"J Clin Investig"},{"issue":"19","key":"4_CR98","doi-asserted-by":"crossref","first-page":"10597","DOI":"10.1016\/S0021-9258(19)85127-X","volume":"260","author":"DJ Messner","year":"1985","unstructured":"Messner DJ, Catterall WA (1985) The sodium channel from rat brain. Separation and characterization of subunits. J Biol Chem 260(19):10597\u201310604","journal-title":"J Biol Chem"},{"issue":"2","key":"4_CR99","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/bi00271a032","volume":"22","author":"JA Miller","year":"1983","unstructured":"Miller JA, Agnew WS, Levinson SR (1983) Principal glycopeptide of the tetrodotoxin\/saxitoxin binding protein from electrophorus electricus: isolation and partial chemical and physical characterization. Biochemistry 22(2):462\u2013470","journal-title":"Biochemistry"},{"issue":"1","key":"4_CR100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbrc.2007.06.170","volume":"361","author":"H Miyazaki","year":"2007","unstructured":"Miyazaki H, Oyama F, Wong HK, Kaneko K, Sakurai T, Tamaoka A, Nukina N (2007) BACE1 modulates filopodia-like protrusions induced by sodium channel beta4 subunit. Biochem Biophys Res Commun 361(1):43\u201348","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"4_CR101","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1073\/pnas.030362197","volume":"97","author":"K Morgan","year":"2000","unstructured":"Morgan K, Stevens EB, Shah B, Cox PJ, Dixon AK, Lee K, Pinnock RD, Hughes J, Richardson PJ, Mizuguchi K, Jackson AP (2000) beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc Natl Acad Sci U S A 97(5):2308\u20132313","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"45","key":"4_CR102","doi-asserted-by":"crossref","first-page":"18577","DOI":"10.1073\/pnas.1209142109","volume":"109","author":"HM Nguyen","year":"2012","unstructured":"Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG (2012) Modulation of voltage-gated K+ channels by the sodium channel beta1 subunit. Proc Natl Acad Sci U S A 109(45):18577\u201318582","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6082","key":"4_CR103","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/322826a0","volume":"322","author":"M Noda","year":"1986","unstructured":"Noda M, Ikeda T, Suzuki H, Takeshima H, Takahashi T, Kuno M, Numa S (1986) Expression of functional sodium channels from cloned cDNA. Nature 322(6082):826\u2013828","journal-title":"Nature"},{"key":"4_CR104","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","volume":"34","author":"RJ O\u2019Brien","year":"2011","unstructured":"O\u2019Brien RJ, Wong PC (2011) Amyloid precursor protein processing and Alzheimer\u2019s disease. Annu Rev Neurosci 34:185\u2013204","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"4_CR105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mcn.2008.10.001","volume":"40","author":"HA O\u2019Malley","year":"2009","unstructured":"O\u2019Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL (2009) Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci 40(2):143\u2013155","journal-title":"Mol Cell Neurosci"},{"issue":"12","key":"4_CR106","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1111\/epi.12040","volume":"53","author":"I Ogiwara","year":"2012","unstructured":"Ogiwara I, Nakayama T, Yamagata T, Ohtani H, Mazaki E, Tsuchiya S, Inoue Y, Yamakawa K (2012) A homozygous mutation of voltage-gated sodium channel beta(I) gene SCN1B in a patient with Dravet syndrome. Epilepsia 53(12):e200\u2013203","journal-title":"Epilepsia"},{"issue":"2\u20133","key":"4_CR107","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(97)00694-0","volume":"234","author":"Y Oh","year":"1997","unstructured":"Oh Y, Lee YJ, Waxman SG (1997) Regulation of Na+ channel beta 1 and beta 2 subunit mRNA levels in cultured rat astrocytes. Neurosci Lett 234(2\u20133):107\u2013110","journal-title":"Neurosci Lett"},{"issue":"3","key":"4_CR108","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/glia.440130303","volume":"13","author":"Y Oh","year":"1995","unstructured":"Oh Y, Waxman SG (1995) Differential Na+ channel beta 1 subunit mRNA expression in stellate and flat astrocytes cultured from rat cortex and cerebellum: a combined in situ hybridization and immunocytochemistry study. Glia 13(3):166\u2013173","journal-title":"Glia"},{"issue":"4","key":"4_CR109","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/cvr\/cvq348","volume":"89","author":"MS Olesen","year":"2011","unstructured":"Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH (2011) Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc Res 89(4):786\u2013793","journal-title":"Cardiovasc Res"},{"issue":"2","key":"4_CR110","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1471-4159.2006.03893.x","volume":"98","author":"F Oyama","year":"2006","unstructured":"Oyama F, Miyazaki H, Sakamoto N, Becquet C, Machida Y, Kaneko K, Uchikawa C, Suzuki T, Kurosawa M, Ikeda T, Tamaoka A, Sakurai T, Nukina N (2006) Sodium channel beta4 subunit: down-regulation and possible involvement in neuritic degeneration in Huntington\u2019s disease transgenic mice. J Neurochem 98(2):518\u2013529","journal-title":"J Neurochem"},{"issue":"41","key":"4_CR111","doi-asserted-by":"crossref","first-page":"14577","DOI":"10.1523\/JNEUROSCI.0361-11.2011","volume":"31","author":"GA Patino","year":"2011","unstructured":"Patino GA, Brackenbury WJ, Bao Y, Lopez-Santiago LF, O'Malley HA, Chen C, Calhoun JD, Lafreniere RG, Cossette P, Rouleau GA, Isom LL (2011) Voltage-gated Na+ channel beta1B: a secreted cell adhesion molecule involved in human epilepsy. J Neurosci 31(41):14577\u201314591","journal-title":"J Neurosci"},{"issue":"34","key":"4_CR112","doi-asserted-by":"crossref","first-page":"10764","DOI":"10.1523\/JNEUROSCI.2475-09.2009","volume":"29","author":"GA Patino","year":"2009","unstructured":"Patino GA, Claes LR, Lopez-Santiago LF, Slat EA, Dondeti RS, Chen C, O'Malley HA, Gray CB, Miyazaki H, Nukina N, Oyama F, De Jonghe P, Isom LL (2009) A functional null mutation of SCN1B in a patient with Dravet syndrome. J Neurosci 29(34):10764\u201310778","journal-title":"J Neurosci"},{"issue":"2","key":"4_CR113","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2010.06.050","volume":"486","author":"GA Patino","year":"2010","unstructured":"Patino GA, Isom LL (2010) Electrophysiology and beyond: multiple roles of Na+ channel beta subunits in development and disease. Neurosci Lett 486(2):53\u201359","journal-title":"Neurosci Lett"},{"issue":"7356","key":"4_CR114","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature10238","volume":"475","author":"J Payandeh","year":"2011","unstructured":"Payandeh J, Scheuer T, Zheng N, Catterall WA (2011) The crystal structure of a voltage-gated sodium channel. Nature 475(7356):353\u2013358","journal-title":"Nature"},{"issue":"47","key":"4_CR115","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1523\/JNEUROSCI.3066-05.2005","volume":"25","author":"M Pertin","year":"2005","unstructured":"Pertin M, Ji RR, Berta T, Powell AJ, Karchewski L, Tate SN, Isom LL, Woolf CJ, Gilliard N, Spahn DR, Decosterd I (2005) Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. J Neurosci 25(47):10970\u201310980","journal-title":"J Neurosci"},{"issue":"12","key":"4_CR116","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nrn1253","volume":"4","author":"S Poliak","year":"2003","unstructured":"Poliak S, Peles E (2003) The local differentiation of myelinated axons at nodes of Ranvier. Nat Rev Neurosci 4(12):968\u2013980","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"4_CR117","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","volume":"16","author":"N Prevarskaya","year":"2010","unstructured":"Prevarskaya N, Skryma R, Shuba Y (2010) Ion channels and the hallmarks of cancer. Trends Mol Med 16(3):107\u2013121","journal-title":"Trends Mol Med"},{"issue":"23","key":"4_CR118","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1046\/j.1432-1033.2003.03878.x","volume":"270","author":"N Qin","year":"2003","unstructured":"Qin N, D\u2019Andrea MR, Lubin ML, Shafaee N, Codd EE, Correa AM (2003) Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. Eur J Biochem\/FEBS 270(23):4762\u20134770","journal-title":"Eur J Biochem\/FEBS"},{"issue":"1","key":"4_CR119","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainresrev.2008.01.003","volume":"58","author":"DS Ragsdale","year":"2008","unstructured":"Ragsdale DS (2008) How do mutant Nav1.1 sodium channels cause epilepsy? Brain Res Rev 58(1):149\u2013159","journal-title":"Brain Res Rev"},{"issue":"12","key":"4_CR120","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1523\/JNEUROSCI.17-12-04517.1997","volume":"17","author":"IM Raman","year":"1997","unstructured":"Raman IM, Bean BP (1997) Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci 17(12):4517\u20134526","journal-title":"J Neurosci"},{"issue":"4","key":"4_CR121","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80969-1","volume":"19","author":"IM Raman","year":"1997","unstructured":"Raman IM, Sprunger LK, Meisler MH, Bean BP (1997) Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 19(4):881\u2013891","journal-title":"Neuron"},{"issue":"8","key":"4_CR122","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrn2852","volume":"11","author":"MN Rasband","year":"2010","unstructured":"Rasband MN (2010) The axon initial segment and the maintenance of neuronal polarity. Nat Rev Neurosci 11(8):552\u2013562","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"4_CR123","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/74805","volume":"3","author":"CF Ratcliffe","year":"2000","unstructured":"Ratcliffe CF, Qu Y, McCormick KA, Tibbs VC, Dixon JE, Scheuer T, Catterall WA (2000) A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta. Nat Neurosci 3(5):437\u2013444","journal-title":"Nat Neurosci"},{"issue":"2","key":"4_CR124","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1083\/jcb.200102086","volume":"154","author":"CF Ratcliffe","year":"2001","unstructured":"Ratcliffe CF, Westenbroek RE, Curtis R, Catterall WA (2001) Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain. J Cell Biol 154(2):427\u2013434","journal-title":"J Cell Biol"},{"issue":"5","key":"4_CR125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1755-5922.2010.00210.x","volume":"28","author":"CA Remme","year":"2010","unstructured":"Remme CA, Bezzina CR (2010) Sodium channel (dys)function and cardiac arrhythmias. Cardiovasc Ther 28(5):287\u2013294","journal-title":"Cardiovasc Ther"},{"issue":"11","key":"4_CR126","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/CIRCRESAHA.109.194423","volume":"104","author":"CA Remme","year":"2009","unstructured":"Remme CA, Scicluna BP, Verkerk AO, Amin AS, van Brunschot S, Beekman L, Deneer VH, Chevalier C, Oyama F, Miyazaki H, Nukina N, Wilders R, Escande D, Houlgatte R, Wilde AA, Tan HL, Veldkamp MW, de Bakker JM, Bezzina CR (2009) Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy. Circ Res 104(11):1283\u20131292","journal-title":"Circ Res"},{"issue":"5550","key":"4_CR127","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1126\/science.1065635","volume":"294","author":"D Ren","year":"2001","unstructured":"Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE (2001) A prokaryotic voltage-gated sodium channel. Science 294(5550):2372\u20132375","journal-title":"Science"},{"issue":"7","key":"4_CR128","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/humu.22328","volume":"34","author":"H Riuro","year":"2013","unstructured":"Riuro H, Beltran-Alvarez P, Tarradas A, Selga E, Campuzano O, Verges M, Pagans S, Iglesias A, Brugada J, Brugada P, Vazquez FM, Perez GJ, Scornik FS, Brugada R (2013) A missense mutation in the sodium channel beta2 subunit reveals SCN2B as a new candidate gene for Brugada syndrome. Hum Mutat 34(7):961\u2013966","journal-title":"Hum Mutat"},{"issue":"7","key":"4_CR129","doi-asserted-by":"crossref","first-page":"E747","DOI":"10.1002\/humu.21041","volume":"30","author":"R Rusconi","year":"2009","unstructured":"Rusconi R, Combi R, Cestele S, Grioni D, Franceschetti S, Dalpra L, Mantegazza M (2009) A rescuable folding defective Nav1.1 (SCN1A) sodium channel mutant causes GEFS+: common mechanism in Nav1.1 related epilepsies? Hum Mutat 30(7):E747\u2013760","journal-title":"Hum Mutat"},{"issue":"41","key":"4_CR130","doi-asserted-by":"crossref","first-page":"11037","DOI":"10.1523\/JNEUROSCI.3515-07.2007","volume":"27","author":"R Rusconi","year":"2007","unstructured":"Rusconi R, Scalmani P, Cassulini RR, Giunti G, Gambardella A, Franceschetti S, Annesi G, Wanke E, Mantegazza M (2007) Modulatory proteins can rescue a trafficking defective epileptogenic Nav1.1 Na+ channel mutant. J Neurosci 27(41):11037\u201311046","journal-title":"J Neurosci"},{"issue":"Pt 1","key":"4_CR131","first-page":"100","volume":"130","author":"IE Scheffer","year":"2007","unstructured":"Scheffer IE, Harkin LA, Grinton BE, Dibbens LM, Turner SJ, Zielinski MA, Xu R, Jackson G, Adams J, Connellan M, Petrou S, Wellard RM, Briellmann RS, Wallace RH, Mulley JC, Berkovic SF (2007) Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. Brain 130(Pt 1):100\u2013109","journal-title":"Brain"},{"issue":"4944","key":"4_CR132","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1126\/science.2154850","volume":"247","author":"T Scheuer","year":"1990","unstructured":"Scheuer T, Auld VJ, Boyd S, Offord J, Dunn R, Catterall WA (1990) Functional properties of rat brain sodium channels expressed in a somatic cell line. Science 247(4944):854\u2013858","journal-title":"Science"},{"issue":"3","key":"4_CR133","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0092-8674(86)90664-1","volume":"46","author":"JW Schmidt","year":"1986","unstructured":"Schmidt JW, Catterall WA (1986) Biosynthesis and processing of the alpha subunit of the voltage-sensitive sodium channel in rat brain neurons. Cell 46(3):437\u2013444","journal-title":"Cell"},{"issue":"14","key":"4_CR134","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1073\/pnas.82.14.4847","volume":"82","author":"J Schmidt","year":"1985","unstructured":"Schmidt J, Rossie S, Catterall WA (1985) A large intracellular pool of inactive Na channel alpha subunits in developing rat brain. Proc Natl Acad Sci U S A 82(14):4847\u20134851","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"4_CR135","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1046\/j.1460-9568.2000.00294.x","volume":"12","author":"BS Shah","year":"2000","unstructured":"Shah BS, Stevens EB, Gonzalez MI, Bramwell S, Pinnock RD, Lee K, Dixon AK (2000) beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain. Eur J Neurosci 12(11):3985\u20133990","journal-title":"Eur J Neurosci"},{"issue":"Pt 3","key":"4_CR136","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1469-7793.2001.t01-1-00763.x","volume":"534","author":"BS Shah","year":"2001","unstructured":"Shah BS, Stevens EB, Pinnock RD, Dixon AK, Lee K (2001) Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta3, in rat CNS. J Physiol 534(Pt 3):763\u2013776","journal-title":"J Physiol"},{"issue":"10","key":"4_CR137","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.braindev.2009.08.009","volume":"31","author":"X Shi","year":"2009","unstructured":"Shi X, Yasumoto S, Nakagawa E, Fukasawa T, Uchiya S, Hirose S (2009) Missense mutation of the sodium channel gene SCN2A causes Dravet syndrome. Brain Dev 31(10):758\u2013762","journal-title":"Brain Dev"},{"issue":"44","key":"4_CR138","doi-asserted-by":"crossref","first-page":"10022","DOI":"10.1523\/JNEUROSCI.2034-04.2004","volume":"24","author":"J Spampanato","year":"2004","unstructured":"Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, Soltesz I, Benna P, Montalenti E, Isom LL, Goldin AL, Meisler MH (2004) A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J Neurosci 24(44):10022\u201310034","journal-title":"J Neurosci"},{"issue":"26","key":"4_CR139","doi-asserted-by":"crossref","first-page":"15753","DOI":"10.1073\/pnas.95.26.15753","volume":"95","author":"J Srinivasan","year":"1998","unstructured":"Srinivasan J, Schachner M, Catterall WA (1998) Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R. Proc Natl Acad Sci U S A 95(26):15753\u201315757","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"4_CR140","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1073\/pnas.111065098","volume":"98","author":"T Sugawara","year":"2001","unstructured":"Sugawara T, Tsurubuchi Y, Agarwala KL, Ito M, Fukuma G, Mazaki-Miyazaki E, Nagafuji H, Noda M, Imoto K, Wada K, Mitsudome A, Kaneko S, Montal M, Nagata K, Hirose S, Yamakawa K (2001) A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proc Natl Acad Sci U S A 98(11):6384\u20136389","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"4_CR141","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/WCO.0b013e3283506714","volume":"25","author":"R Surges","year":"2012","unstructured":"Surges R, Sander JW (2012) Sudden unexpected death in epilepsy: mechanisms, prevalence, and prevention. Curr Opin Neurol 25(2):201\u2013207","journal-title":"Curr Opin Neurol"},{"issue":"21","key":"4_CR142","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.1016\/S0021-9258(19)38359-0","volume":"265","author":"EM Sutkowski","year":"1990","unstructured":"Sutkowski EM, Catterall WA (1990) Beta 1 subunits of sodium channels. Studies with subunit-specific antibodies. J Biol Chem 265(21):12393\u201312399","journal-title":"J Biol Chem"},{"issue":"2","key":"4_CR143","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0306-4522(03)00432-9","volume":"121","author":"N Takahashi","year":"2003","unstructured":"Takahashi N, Kikuchi S, Dai Y, Kobayashi K, Fukuoka T, Noguchi K (2003) Expression of auxiliary beta subunits of sodium channels in primary afferent neurons and the effect of nerve injury. Neuroscience 121(2):441\u2013450","journal-title":"Neuroscience"},{"issue":"6","key":"4_CR144","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.hrthm.2010.01.032","volume":"7","author":"BH Tan","year":"2010","unstructured":"Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, Makielski JC, Ackerman MJ (2010) Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm 7(6):771\u2013778","journal-title":"Heart Rhythm"},{"issue":"4","key":"4_CR145","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1124\/mol.111.072751","volume":"80","author":"JW Theile","year":"2011","unstructured":"Theile JW, Cummins TR (2011) Inhibition of Navbeta4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide. Mol Pharmacol 80(4):724\u2013734","journal-title":"Mol Pharmacol"},{"issue":"50","key":"4_CR146","doi-asserted-by":"crossref","first-page":"42001","DOI":"10.1074\/jbc.M112.421883","volume":"287","author":"CH Thompson","year":"2012","unstructured":"Thompson CH, Porter JC, Kahlig KM, Daniels MA, George AL Jr (2012) Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression. J Biol Chem 287(50):42001\u201342008","journal-title":"J Biol Chem"},{"issue":"6","key":"4_CR147","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.hrthm.2010.02.025","volume":"7","author":"JA Towbin","year":"2010","unstructured":"Towbin JA (2010) The A, B, Cs of sudden infant death syndrome: an electrical disorder? Heart Rhythm 7(6):779\u2013780","journal-title":"Heart Rhythm"},{"issue":"8","key":"4_CR148","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/mcp.O112.018366","volume":"11","author":"JC Trinidad","year":"2012","unstructured":"Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11(8):215\u2013229","journal-title":"Mol Cell Proteomics"},{"issue":"11","key":"4_CR149","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/j.1528-1167.2012.03675.x","volume":"53","author":"M Uebachs","year":"2012","unstructured":"Uebachs M, Albus C, Opitz T, Isom L, Niespodziany I, Wolff C, Beck H (2012) Loss of beta1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents. Epilepsia 53(11):1959\u20131967","journal-title":"Epilepsia"},{"issue":"25","key":"4_CR150","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.1523\/JNEUROSCI.1534-10.2010","volume":"30","author":"M Uebachs","year":"2010","unstructured":"Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J Neurosci 30(25):8489\u20138501","journal-title":"J Neurosci"},{"issue":"27","key":"4_CR151","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1523\/JNEUROSCI.1101-06.2006","volume":"26","author":"A Van Wart","year":"2006","unstructured":"Van Wart A, Matthews G (2006) Impaired firing and cell-specific compensation in neurons lacking nav1.6 sodium channels. J Neurosci 26(27):7172\u20137180","journal-title":"J Neurosci"},{"issue":"2","key":"4_CR152","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/cne.21173","volume":"500","author":"A Van Wart","year":"2007","unstructured":"Van Wart A, Trimmer JS, Matthews G (2007) Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol 500(2):339\u2013352","journal-title":"J Comp Neurol"},{"issue":"8","key":"4_CR153","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1016\/S0021-9258(18)32546-8","volume":"258","author":"CJ Waechter","year":"1983","unstructured":"Waechter CJ, Schmidt JW, Catterall WA (1983) Glycosylation is required for maintenance of functional sodium channels in neuroblastoma cells. J Biol Chem 258(8):5117\u20135123","journal-title":"J Biol Chem"},{"issue":"9","key":"4_CR154","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1212\/WNL.58.9.1426","volume":"58","author":"RH Wallace","year":"2002","unstructured":"Wallace RH, Scheffer IE, Parasivam G, Barnett S, Wallace GB, Sutherland GR, Berkovic SF, Mulley JC (2002) Generalized epilepsy with febrile seizures plus: mutation of the sodium channel subunit SCN1B. Neurology 58(9):1426\u20131429","journal-title":"Neurology"},{"issue":"4","key":"4_CR155","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/1252","volume":"19","author":"RH Wallace","year":"1998","unstructured":"Wallace RH, Wang DW, Singh R, Scheffer IE, George AL Jr, Phillips HA, Saar K, Reis A, Johnson EW, Sutherland GR, Berkovic SF, Mulley JC (1998) Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet 19(4):366\u2013370","journal-title":"Nat Genet"},{"issue":"3","key":"4_CR156","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/CIRCULATIONAHA.106.646513","volume":"115","author":"DW Wang","year":"2007","unstructured":"Wang DW, Desai RR, Crotti L, Arnestad M, Insolia R, Pedrazzini M, Ferrandi C, Vege A, Rognum T, Schwartz PJ, George AL Jr (2007) Cardiac sodium channel dysfunction in sudden infant death syndrome. Circulation 115(3):368\u2013376","journal-title":"Circulation"},{"issue":"3","key":"4_CR157","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1161\/CIRCEP.108.779181","volume":"2","author":"H Watanabe","year":"2009","unstructured":"Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM (2009) Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2(3):268\u2013275","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"6","key":"4_CR158","first-page":"2260","volume":"118","author":"H Watanabe","year":"2008","unstructured":"Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott JJ, Demolombe S, Probst V, Anselme F, Escande D, Wiesfeld AC, Pfeufer A, Kaab S, Wichmann HE, Hasdemir C, Aizawa Y, Wilde AA, Roden DM, Bezzina CR (2008) Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Investig 118(6):2260\u20132268","journal-title":"J Clin Investig"},{"issue":"12","key":"4_CR159","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrn2023","volume":"7","author":"SG Waxman","year":"2006","unstructured":"Waxman SG (2006) Axonal conduction and injury in multiple sclerosis: the role of sodium channels. Nat Rev Neurosci 7(12):932\u2013941","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"4_CR160","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI42219","volume":"120","author":"VC Wimmer","year":"2010","unstructured":"Wimmer VC, Reid CA, Mitchell S, Richards KL, Scaf BB, Leaw BT, Hill EL, Royeck M, Horstmann MT, Cromer BA, Davies PJ, Xu R, Lerche H, Berkovic SF, Beck H, Petrou S (2010) Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J Clin Investig 120(8):2661\u20132671","journal-title":"J Clin Investig"},{"issue":"24","key":"4_CR161","doi-asserted-by":"crossref","first-page":"23009","DOI":"10.1074\/jbc.M414648200","volume":"280","author":"HK Wong","year":"2005","unstructured":"Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N (2005) beta subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. J Biol Chem 280(24):23009\u201323017","journal-title":"J Biol Chem"},{"issue":"37","key":"4_CR162","doi-asserted-by":"crossref","first-page":"26511","DOI":"10.1074\/jbc.274.37.26511","volume":"274","author":"ZC Xiao","year":"1999","unstructured":"Xiao ZC, Ragsdale DS, Malhotra JD, Mattei LN, Braun PE, Schachner M, Isom LL (1999) Tenascin-R is a functional modulator of sodium channel beta subunits. J Biol Chem 274(37):26511\u201326517","journal-title":"J Biol Chem"},{"issue":"1","key":"4_CR163","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuroscience.2007.05.038","volume":"148","author":"R Xu","year":"2007","unstructured":"Xu R, Thomas EA, Gazina EV, Richards KL, Quick M, Wallace RH, Harkin LA, Heron SE, Berkovic SF, Scheffer IE, Mulley JC, Petrou S (2007) Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience 148(1):164\u2013174","journal-title":"Neuroscience"},{"issue":"2","key":"4_CR164","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10549-012-2102-9","volume":"134","author":"M Yang","year":"2012","unstructured":"Yang M, Kozminski DJ, Wold LA, Modak R, Calhoun JD, Isom LL, Brackenbury WJ (2012) Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer. Breast Cancer Res Treat 134(2):603\u2013615","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"4_CR165","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1096\/fj.12-209445","volume":"27","author":"NR Yereddi","year":"2013","unstructured":"Yereddi NR, Cusdin FS, Namadurai S, Packman LC, Monie TP, Slavny P, Clare JJ, Powell AJ, Jackson AP (2013) The immunoglobulin domain of the sodium channel beta3 subunit contains a surface-localized disulfide bond that is required for homophilic binding. FASEB J 27(2):568\u2013580","journal-title":"FASEB J"},{"issue":"20","key":"4_CR166","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.1523\/JNEUROSCI.23-20-07577.2003","volume":"23","author":"FH Yu","year":"2003","unstructured":"Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, Scheuer T, Curtis R (2003) Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci 23(20):7577\u20137585","journal-title":"J Neurosci"},{"issue":"5","key":"4_CR167","doi-asserted-by":"crossref","first-page":"630","DOI":"10.7150\/ijbs.3684","volume":"8","author":"TT Zhou","year":"2012","unstructured":"Zhou TT, Zhang ZW, Liu J, Zhang JP, Jiao BH (2012) Glycosylation of the sodium channel beta4 subunit is developmentally regulated and involves in neuritic degeneration. Int J Biol Sci 8(5):630\u2013639","journal-title":"Int J Biol Sci"}],"container-title":["Handbook of Experimental Pharmacology","Voltage Gated Sodium Channels"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-41588-3_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T01:45:48Z","timestamp":1676857548000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-642-41588-3_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9783642415876","9783642415883"],"references-count":167,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-41588-3_4","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"15 February 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}