{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:09:29Z","timestamp":1758701369883},"publisher-location":"Berlin, Heidelberg","reference-count":133,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783642641947"},{"type":"electronic","value":"9783642599514"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999]]},"DOI":"10.1007\/978-3-642-59951-4_7","type":"book-chapter","created":{"date-parts":[[2011,9,18]],"date-time":"2011-09-18T02:16:57Z","timestamp":1316312217000},"page":"113-135","source":"Crossref","is-referenced-by-count":26,"title":["Effector and Regulatory Lymphoid Cells and Cytokines in Mucosal Sites"],"prefix":"10.1007","author":[{"given":"T. T.","family":"MacDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"7_CR1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/eji.1830260204","volume":"26","author":"AN Akbar","year":"1996","unstructured":"Akbar AN, Borthwick NJ, Wickremasinghe RG, Panayoitidis P, Pilling D, Bofill M, Krajewski S, Reed JC, Salmon M (1996) Interleukin-2 receptor common chain signalling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl- 2,bel-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur J Immunol 26:294\u201329","journal-title":"Eur J Immunol"},{"key":"7_CR2","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.4049\/jimmunol.158.7.3464","volume":"158","author":"B Aranda","year":"1997","unstructured":"Aranda B, Sydora BC, McAllister PL, Binder SW, Yang HY, Targan SR, Kronenberg M (1997) Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4 +, CD45RBhi T cells to SCID recipients. J Immunol 158:3464\u201373","journal-title":"J Immunol"},{"key":"7_CR3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00194698","volume":"426","author":"F Autschbach","year":"1995","unstructured":"Autschbach F, Schurmann G, Qiao L, Merz H, Wallich R, Meuer SC (1995) Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn\u2019s disease. Virchows Arch 426:51\u201360","journal-title":"Virchows Arch"},{"key":"7_CR4","first-page":"1469","volume":"151","author":"M Bajaj-Elliot","year":"1997","unstructured":"Bajaj-Elliot M, Breese E, Poulsom R, Fairclough PD, Pender SF, MacDonald TT (1997) Keratinocyte growth factor in inflammatory bowel disease: increased mRNA transcripts in ulcerative colitis compared to Crohn\u2019s disease in biopsies and isolated stromal cells. Am J Pathol 151:1469\u20131476","journal-title":"Am J Pathol"},{"key":"7_CR5","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1126\/science.1716785","volume":"253","author":"SP Balk","year":"1991","unstructured":"Balk SP, Ebert EC, Blumenthal RL, McDermott FV, Wucherpfennig KW, Landau SB, Blumberg RS (1991) Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 253:1411\u20131415","journal-title":"Science"},{"key":"7_CR6","first-page":"666","volume":"80","author":"S Bao","year":"1993","unstructured":"Bao S, Goldstone S, Husband AJ (1993) Localisation of IFN-gamma and IL-6 mRNA in murine intestine by in situ hybridisation. Immunology 80:666\u2013670","journal-title":"Immunology"},{"key":"7_CR7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/1529-0131(199802)41:2<290::AID-ART13>3.0.CO;2-R","volume":"41","author":"ML Barnet","year":"1998","unstructured":"Barnet ML, Kremer JM, St Clair EW, Clegg DO, F\u00fcrst D, Weisman M, Fletcher MJ, Chasan-Taber S, Finger E, Morales A, Le CH, Trentham DE (1998) Treatment of rheumatoid arthritis with oral type II collagen. Arthritis Rheum 41:290\u2013297","journal-title":"Arthritis Rheum"},{"key":"7_CR8","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/gut.39.6.818","volume":"39","author":"CG Beckett","year":"1996","unstructured":"Beckett CG, Dell\u2019Olio D, Kontakou M, Przemioslo RT, Rosen-Bronson S, Ciclitira PJ (1996) Analysis of interleukin-4 and interleukin-10 and their association with the lymphocytic infiltrate in the small intestine of patients with coeliac disease. Gut 39:818\u201323","journal-title":"Gut"},{"key":"7_CR9","first-page":"90","volume":"101","author":"M Berg","year":"1991","unstructured":"Berg M, Murakawa Y, Camerini D, James SP (1991) Lamina propria lymphocytes are derived from circulating cells that lack the Leu-8 lymph node homing receptor. J Immunol 101:90\u201399","journal-title":"J Immunol"},{"key":"7_CR10","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1172\/JCI118861","volume":"98","author":"DJ Berg","year":"1996","unstructured":"Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+ Thl-like responses. J Clin Invest 98:1010\u20131020","journal-title":"J Clin Invest"},{"key":"7_CR11","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1128\/IAI.65.7.2676-2684.1997","volume":"65","author":"C Berquist","year":"1997","unstructured":"Berquist C, Johansson EL, Lagergard T, Holmgren J, Rudin A (1997) Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and vagina. Infect Immun 65:2676\u20132684","journal-title":"Infect Immun"},{"key":"7_CR12","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1172\/JCI119082","volume":"98","author":"M Boirivant","year":"1996","unstructured":"Boirivant M, Pica R, DeMaria R, Testi R, Pallone F, Strober W (1996) Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. J Clin Invest 98:2616\u20132622","journal-title":"J Clin Invest"},{"key":"7_CR13","doi-asserted-by":"crossref","first-page":"985","DOI":"10.4049\/jimmunol.157.3.985","volume":"157","author":"R Boismenu","year":"1996","unstructured":"Boismenu R, Feng L, Xia YY, Chang JCC, Havran WL (1996) Chemokine expression by intraepithelial T cells. J Immunol 157:985\u2013992","journal-title":"J Immunol"},{"key":"7_CR14","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/0016-5085(89)90406-X","volume":"97","author":"P Brandtzaeg","year":"1989","unstructured":"Brandtzaeg P, Hastensen TS, Kett K, Krajki P, Kvale D, Rognum TO, Scott H, Sollid LM (1989) Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology 97:1562\u20131584","journal-title":"Gastroenterology"},{"key":"7_CR15","first-page":"521","volume":"149","author":"M Brauchle","year":"1996","unstructured":"Brauchle M, Madiener M, Wagner AD, Angermeyer K, Lauer U, Hofschneider PH, Gregor M, Werner S (1996) Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease. Am J Pathol 149:521\u2013529","journal-title":"Am J Pathol"},{"key":"7_CR16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/gut.41.2.215","volume":"41","author":"J Braunstein","year":"1997","unstructured":"Braunstein J, Qiao L, Autschbach F, Schurmann G, Meuer S (1997) T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 41:215\u2013220","journal-title":"Gut"},{"key":"7_CR17","first-page":"127","volume":"78","author":"E Breese","year":"1993","unstructured":"Breese E, Braegger CP, Corrigan CR, Walker-Smith JA, MacDonald TT (1993) Interleukin-2 and interferon-\u03b3 secreting T cells in normal and diseased human intestinal mucosa. Immunology 78:127\u2013131","journal-title":"Immunology"},{"key":"7_CR18","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/BF02090378","volume":"39","author":"EJ Breese","year":"1994","unstructured":"Breese EJ, Farthing MJG, Kumar P, MacDonald TT (1994a) Interleukin-2 and interferon-gamma producing cells in the lamina propria in coeliac disease. Dig Dis Sci 39:2243","journal-title":"Dig Dis Sci"},{"key":"7_CR19","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/0016-5085(94)90398-0","volume":"106","author":"EJ Breese","year":"1994","unstructured":"Breese EJ, Michie CA, Nicholls SW, Murch SH, Williams CB, Domizio P, Walker-Smith JA, MacDonald TT (1994b) Tumour necrosis factor-alpha producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 106:1455\u20131466","journal-title":"Gastroenterology"},{"key":"7_CR20","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.4049\/jimmunol.158.12.5883","volume":"158","author":"D Buzoni-Gatel","year":"1997","unstructured":"Buzoni-Gatel D, Lepage AC, Dimier-Poisson IH, Bout DT, Kasper LH (1997) Adoptive transfer of gut intraepithelial lymphocytes protects against murine infection with Toxoplasma gondii. J Immunol 158:5883\u20135889","journal-title":"J Immunol"},{"key":"7_CR21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/gut.42.5.643","volume":"42","author":"M Carol","year":"1998","unstructured":"Carol M, Lambrechts A, Van Gossum A, Libin M, Goldman M, Mascart-Lemone F (1998) Spontaneous secretion of interferon-gamma and interleukin-4 by human intraepithelial and lamina propria gut lymphocytes. Gut 42:643\u20139","journal-title":"Gut"},{"key":"7_CR22","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.4049\/jimmunol.154.5.2434","volume":"154","author":"V Casini-Raggi","year":"1995","unstructured":"Casini-Raggi V, Kam L, Chong YJT, Ficchi C, Pizzaro TT, Cominelli F (1995) Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. J Immunol 154:2434\u20132440","journal-title":"J Immunol"},{"key":"7_CR23","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.4049\/jimmunol.153.10.4596","volume":"153","author":"T Chardes","year":"1994","unstructured":"Chardes T, Buzoni-Gatel D, Lepage A, Bernard F, Bout D (1994) Toxoplasma gondii oral infection induces specific cytotoxic CD8\u03b1\u00df-Thl+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes. J Immunol 153:4596\u2013603","journal-title":"J Immunol"},{"key":"7_CR24","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1126\/science.7520605","volume":"265","author":"Y Chen","year":"1994","unstructured":"Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL (1994) Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237\u20131240","journal-title":"Science"},{"key":"7_CR25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/376177a0","volume":"376","author":"Y Chen","year":"1995","unstructured":"Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL (1995) Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376:177\u2013180","journal-title":"Nature"},{"key":"7_CR26","doi-asserted-by":"crossref","first-page":"910","DOI":"10.4049\/jimmunol.155.2.910","volume":"155","author":"Y Chen","year":"1995","unstructured":"Chen Y, Inobe J, Weiner HL (1995) Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediated active suppression. J Immunol 155:910\u2013916","journal-title":"J Immunol"},{"key":"7_CR27","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1073\/pnas.93.1.388","volume":"93","author":"Y Chen","year":"1996","unstructured":"Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA, Weiner HL (1996) Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose- dependent induction of regulatory cells. Proc Natl Acad Sci USA 93:388\u2013391","journal-title":"Proc Natl Acad Sci USA"},{"key":"7_CR28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/eji.1830230622","volume":"23","author":"CF Cuff","year":"1993","unstructured":"Cuff CF, Cebra CK, Rubin DH, Cebra JJ (1993) Developmental relationship between cytotoxic T cell receptor \u03b1\u00df-positive intraepithelial lymphocytes and Peyer\u2019s patch lymphocytes. Eur J Immunol 23:1333\u20131339","journal-title":"Eur J Immunol"},{"key":"7_CR29","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1073\/pnas.93.2.956","volume":"93","author":"R Daniel","year":"1996","unstructured":"Daniel R, Wegmann DR (1996) Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9\u201323). Proc Natl Acad Sei USA 93:956\u2013960","journal-title":"Proc Natl Acad Sei USA"},{"key":"7_CR30","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/eji.1830270723","volume":"27","author":"MM D\u2019Elios","year":"1997","unstructured":"D\u2019Elios MM, Manghetti M, Almerigogna F, Amedei A, Costa F, Burroni D, Baldari CT, Romagnani S, Telford JL, Del Prete G (1997a) Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with and without peptic ulcer. Eur J Immunol 27:1751\u20131755","journal-title":"Eur J Immunol"},{"key":"7_CR31","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.158.2.962","volume":"158","author":"MM D\u2019Elios","year":"1997","unstructured":"D\u2019Elios MM, Manghetti M, DeCarli M, Costa F, Baldari CT, Burroni D, Telford JL, Romagnani S, Del Prete G (1997b) T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J Immunol 158:962\u2013967","journal-title":"J Immunol"},{"key":"7_CR32","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1172\/JCI118418","volume":"97","author":"M Maria De","year":"1996","unstructured":"De Maria M, Boirivant M, Cifone MG, Roncaioli P, Hahne M, Tschopp J, Pallone F, Santoni A, Testi R (1996) Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes: a potential role for acidic sphingomyelinase pathway in normal immunoregulation. J Clin Invest 97:316\u2013322","journal-title":"J Clin Invest"},{"key":"7_CR33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0016-5085(97)70116-1","volume":"113","author":"P Desreumaux","year":"1997","unstructured":"Desreumaux P, Brandt E, Gambiez L, Emilie D, Geboes K, Klein O, Ectors N, Cortot A, Capron M, Colombel JF (1997) Distinct cytokine patterns in early and chronic ileal lesions of Crohn\u2019s disease. Gastroenterology 113:118\u2013126","journal-title":"Gastroenterology"},{"key":"7_CR34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0008-8749(86)90093-6","volume":"103","author":"SB Dillon","year":"1986","unstructured":"Dillon SB, Dalton BJ, MacDonald TT (1986) Lymphokine production by antigen and mitogen activated murine intraepithelial lymphocytes. Cell Immunol 103:326\u2013338","journal-title":"Cell Immunol"},{"key":"7_CR35","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/eji.1830260432","volume":"26","author":"R Duchmann","year":"1996","unstructured":"Duchmann R, Schmitt E, Knolle P, Meyer zum Buschenfelde KH, Neurath M (1996) Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur J Immunol 26:934\u20138","journal-title":"Eur J Immunol"},{"key":"7_CR36","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/0016-5085(93)91064-O","volume":"105","author":"L Eckman","year":"1993","unstructured":"Eckman L, Jung HC, Schuerer-Maly CC, Panja A, Morzycka-Wroblewska E, Kagnoff MF (1993) Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of IL-8. Gastroenterology 105:1689\u20131697","journal-title":"Gastroenterology"},{"key":"7_CR37","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/0016-5085(95)90599-5","volume":"109","author":"CO Elson","year":"1995","unstructured":"Elson CO, Sartor RB, Tennyson GS, Riddell RH (1995) Experimental models of inflammatory bowel disease. Gastroenterology 109:1344\u20131367","journal-title":"Gastroenterology"},{"key":"7_CR38","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.4049\/jimmunol.157.5.2174","volume":"157","author":"CO Elson","year":"1996","unstructured":"Elson CO, Beagley KW, Sharmanov AT, Fujihashi K, Kiyono H, Tennyson GS, Cong Y, Black CA, Ridwan BW, McGhee JR (1996) Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. J Immunol 157:2174\u20132185","journal-title":"J Immunol"},{"key":"7_CR39","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/IAI.64.2.569-575.1996","volume":"64","author":"M Emoto","year":"1996","unstructured":"Emoto M, Neuhaus O, Emoto Y, Kaufmann SH (1996) Influence of \u03b22-microglobulin expression on gamma-interferon secretion and target cell lysis by intraepithelial lymphocytes during intestinal Listeria monocytogenes infection. Infect Immun 64:569\u2013575","journal-title":"Infect Immun"},{"key":"7_CR40","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1365-2567.1996.d01-727.x","volume":"89","author":"IN Farstad","year":"1996","unstructured":"Farstad IN, Halstensen TS, Lien B, Kilshaw PJ, Lazarovitz AI, Brandtzaeg P (1996) Distribution of (37 integrins in human intestinal mucosa and organised gut-associated lymphoid tissue. Immunology 89:227\u2013237","journal-title":"Immunology"},{"key":"7_CR41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0016-5085(97)70231-2","volume":"112","author":"IN Farstad","year":"1997","unstructured":"Farstad IN, Norstein J, Brandtzaeg P (1997a) Phenotypes of B and T cells in human intestinal and mesenteric lymph. Gastroenterology 112:163\u2013173","journal-title":"Gastroenterology"},{"key":"7_CR42","first-page":"187","volume":"150","author":"IN Farstad","year":"1997","unstructured":"Farstad IN, Halstensen TS, Kvale D, Fausa O, Brandtzaeg P (1997a) Topographic distribution of homing receptors on B and T cells in human gut associated lymphoid tissue. Am J Pathol 150:187\u2013199","journal-title":"Am J Pathol"},{"key":"7_CR43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/gut.16.2.114","volume":"16","author":"A Ferguson","year":"1975","unstructured":"Ferguson A, Jarrett EEE (1975) Hypersensitivity reactions in small intestine. 1. Thymus-dependence of experimental \u201cpartial villous atrophy\u201d. Gut 16:114\u2013117","journal-title":"Gut"},{"key":"7_CR44","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1053\/gast.1996.v110.pm8566591","volume":"110","author":"PW Finch","year":"1996","unstructured":"Finch PW, Pricolo V, Wu A, Finkelstein SD (1996) Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. Gastroenterology 110:441\u2013451","journal-title":"Gastroenterology"},{"key":"7_CR45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1172\/JCI118779","volume":"98","author":"H Fukaura","year":"1996","unstructured":"Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA (1996) Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-\u03b21- secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 98:70\u201377","journal-title":"J Clin Invest"},{"key":"7_CR46","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1084\/jem.175.3.695","volume":"175","author":"K Fujihashi","year":"1992","unstructured":"Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone J A, Eldridge JH, Kiyono H (1992) Immunoregulatory functions for murine intraepithelial lymphocytes: \u03b3\u03b4 T cell receptor-positive (TCR +) T cells abrogate oral tolerance, while ap TCR + T cells provide B cell help. J Exp Med 175:695\u2013707","journal-title":"J Exp Med"},{"key":"7_CR47","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.4049\/jimmunol.151.12.6681","volume":"151","author":"K Fujihashi","year":"1993","unstructured":"Fujihashi K, Yamamoto M, McGhee JR, Kiyono H (1993) \u03b1\u03b2 T cell receptor-positive intraepithelial lymphocytes with CD4 +, 8- and CD4 +, CD8 + phenotypes from orally immunized mice provide Th2-like function for B cells responses. J Immunol 151:6681\u20136691","journal-title":"J Immunol"},{"key":"7_CR48","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.157.3.1261","volume":"157","author":"IJ Fuss","year":"1996","unstructured":"Fuss I J, Neurath M, Boirivant M, Klein JS, de la Motte C, Strong SA, Fiocchi C, Strober W (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. J Immunol 157:1261\u20131270","journal-title":"J Immunol"},{"key":"7_CR49","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.4049\/jimmunol.154.11.5649","volume":"154","author":"P Garside","year":"1995","unstructured":"Garside P, Steel M, Worthey EA, Satoskar A, Alexander J, Bluethmann H, Liew FY, Mowat AM (1995) T helper 2 cells are subject to high dose oral tolerance induction. J Immunol 154:5649\u20135655","journal-title":"J Immunol"},{"key":"7_CR50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0950-3528(96)90049-4","volume":"10","author":"M Goke","year":"1996","unstructured":"Goke M, Podolsky DK (1996) Regulation of the mucosal epithelial barrier. Baillieres Clin Gastroenterol 10:393\u2013405","journal-title":"Baillieres Clin Gastroenterol"},{"key":"7_CR51","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","volume":"389","author":"H Groux","year":"1997","unstructured":"Groux H, O\u2019Garra A, Bigler M, Rouleau M, Antonenko S, DeVries JE, Roncarolo MG (1997) A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737\u2013742","journal-title":"Nature"},{"key":"7_CR52","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1084\/jem.173.2.471","volume":"173","author":"D Guy-Grand","year":"1991","unstructured":"Guy-Grand D, Cerf-Bensussan N, Malissen B, Malassis-Seris M, Briottet C, Vassalli P (1991) Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med 173:471\u2013481","journal-title":"J Exp Med"},{"key":"7_CR53","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1002\/eji.1830260942","volume":"26","author":"D Guy-Grand","year":"1996","unstructured":"Guy-Grand D, Cuenod-Jabri B, Malassis-Seris M, Selz F, Vassalli P (1996) Complexity of the mouse gut T cell immune system:identification of two distinct natural killer T cell intraepithelial lineages. Eur J Immunol 26:2248\u20132256","journal-title":"Eur J Immunol"},{"key":"7_CR54","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1084\/jem.185.12.2101","volume":"185","author":"A Hagenbaugh","year":"1997","unstructured":"Hagenbaugh A, Sharma S, Dubinett SM, Wei SH-Y, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M (1997) Altered immune responses in interleukin 10 transgenic mice. J Exp Med 185:2101\u20132110","journal-title":"J Exp Med"},{"key":"7_CR55","first-page":"460","volume":"71","author":"TS Haistensen","year":"1990","unstructured":"Haistensen TS, Farstad IN, Scott H, Fausa O, Brandtzaeg P (1990) Intraepithelial TcR \u03b1\u00df+ lymphocytes express CD45R0 more often than the TcR \u03b3\u03b4 counterparts in celiac disease. Immunology 71:460\u2013466","journal-title":"Immunology"},{"key":"7_CR56","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1365-3083.1993.tb03245.x","volume":"38","author":"TS Haistensen","year":"1993","unstructured":"Haistensen TS, Scott H, Fausa O, Brandtzaeg P (1993) Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia. Scand J Immunol 38:581\u2013590","journal-title":"Scand J Immunol"},{"key":"7_CR57","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.4049\/jimmunol.159.9.4484","volume":"159","author":"K Haneda","year":"1997","unstructured":"Haneda K, Sano K, Tamura G, Sato T, Habu S, Shirato K (1997) TGF\u00df induced by oral tolerance ameliorates experimental tracheal eosinophilia. J Immunol 159:4484\u20134490","journal-title":"J Immunol"},{"key":"7_CR58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199711000-00014","volume":"42","author":"AC Hauer","year":"1997","unstructured":"Hauer AC, Breese EJ, Walker-Smith JA, MacDonald TT (1997) The frequency of cells secreting inter- feron-\u03b3, IL-4, IL-5 and IL-10 in the blood and duodenal mucosa of children with cows\u2019 milk hypersensitivity. Pediatr Res 42:1\u201310","journal-title":"Pediatr Res"},{"key":"7_CR59","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/0016-5085(94)90405-7","volume":"106","author":"M Heyman","year":"1994","unstructured":"Heyman M, Darmon N, Dupont C, Dugas B, Hirribaren A, Blaton MA, Desjeux JF (1994) Mononuclear cells from infants allergic to cow\u2019s milk secrete tumor necrosis factor a, altering intestinal function. Gastroenterology 106:1514\u20131523","journal-title":"Gastroenterology"},{"key":"7_CR60","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1172\/JCI118097","volume":"96","author":"W Holtmeier","year":"1995","unstructured":"Holtmeier W, Chowers Y, Lumeng A, Morzycka-Wroblewska E, Kagnoff MF (1995) The \u03b4T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage. J Clin Invest 96:1108\u20131117","journal-title":"J Clin Invest"},{"key":"7_CR61","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.4049\/jimmunol.158.12.5632","volume":"158","author":"W Holtmeier","year":"1997","unstructured":"Holtmeier W, Witthoft T, Hennemann A, Winter HS, Kagnoff MF (1997) The TCR\u03b4 repertoire in human intestine undergoes characteristic changes during fetal to adult development. J Immunol 158:5632\u20135641","journal-title":"J Immunol"},{"key":"7_CR62","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1002\/eji.1830230914","volume":"23","author":"E Horaquist","year":"1993","unstructured":"Horaquist E, Lycke N (1993) Cholera toxin adjuvant greatly promotes antigen priming of T cells. Eur J Immunol 23:2136\u20132143","journal-title":"Eur J Immunol"},{"key":"7_CR63","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1084\/jem.178.5.1783","volume":"178","author":"GF Hoyne","year":"1993","unstructured":"Hoyne GF, O\u2019Hehir RE, Wraith DC, Thomas WR, Lamb JR (1993) Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in na and sensitised mice. J Exp Med 178:1783\u20131788","journal-title":"J Exp Med"},{"key":"7_CR64","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.4049\/jimmunol.152.9.4663","volume":"152","author":"S Husby","year":"1994","unstructured":"Husby S, Mestecky J, Moldoveanu Z, Holland S, Elson CO (1994) Oral tolerance in humans. J Immunol 152:4663\u20134670","journal-title":"J Immunol"},{"key":"7_CR65","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/eji.1830200523","volume":"20","author":"A Jarry","year":"1990","unstructured":"Jarry A, Cerf-Bensussan N, Brousse N, Selz F, Guy-Grand D (1990) Subsets of CD3 + (T cell receptor \u03b1\u00df or \u03b3\u03b4) and CD3- lymphocytes isolated from normal human gut epithelium display phenotypic features different from their counterparts in peripheral blood. Eur J Immunol 20:1097\u20132103","journal-title":"Eur J Immunol"},{"key":"7_CR66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI117676","volume":"95","author":"HC Jung","year":"1995","unstructured":"Jung HC, Eckmann L, Yang S-K, Panja A, Fierer J, Morzycka-Wroblewska E, Kagnoff MF (1995) A distinct array of pro-inflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 95:55\u201365","journal-title":"J Clin Invest"},{"key":"7_CR67","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0016-5085(97)70135-5","volume":"112","author":"GC Kaiser","year":"1997","unstructured":"Kaiser GC, Polk DB (1997) Tumor necrosis factor a regulates proliferation in a mouse intestinal cell line. Gastroenterology 112:1231\u20131240","journal-title":"Gastroenterology"},{"key":"7_CR68","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/jcp.47.11.1015","volume":"11","author":"R Karttunen","year":"1994","unstructured":"Karttunen R, Breese E, MacDonald TT (1994) Loss of interleukin-4 secreting cells in inflammatory bowel disease. J Clin Path 11:1015\u20131018","journal-title":"J Clin Path"},{"key":"7_CR69","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/gut.36.3.341","volume":"36","author":"R Karttunen","year":"1995","unstructured":"Karttunen R, Karttunnen T, Ekre H-P T, MacDonald TT (1995) Interferon-gamma and interleukin-4 secreting cells in the gastric antrum in Helicobacter pylori associated gastritis. Gut 36:341\u2013345","journal-title":"Gut"},{"key":"7_CR70","first-page":"1355","volume":"176","author":"SJ Khoury","year":"1992","unstructured":"Khoury SJ, Hancock WW, Weiner HL (1992) Oral tolerance to myelin basic recovery and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of TGF\u00df, interleukin-4, and prostaglandin E expression in the brain. J Exp Med 176:1355\u20131364","journal-title":"E expression in the brain. J Exp Med"},{"key":"7_CR71","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.4049\/jimmunol.159.4.1775","volume":"159","author":"JC Koningsberger","year":"1997","unstructured":"Koningsberger JC, Chott A, Logtenberg T, Wiegman LJ, Blumberg RS, van Berge Henegouwen GP, Balk SP (1997) TCR expression in human fetal intestine and identification of an early T cell receptor \u00df-chain transcript. J Immunol 159:1775\u20131782","journal-title":"J Immunol"},{"key":"7_CR72","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1136\/gut.37.1.52","volume":"37","author":"M Kontakou","year":"1995","unstructured":"Kontakou M, Przemioslo RT, Sturgess RP, Limb GA, Ellis HJ, Day P, Ciclitira PJ (1995) Cytokine mRNA expression in the mucosa of treated coeliac patients after wheat peptide challenge. Gut 37:52- 57","journal-title":"Gut"},{"key":"7_CR73","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/0092-8674(95)90349-6","volume":"80","author":"VK Kuchroo","year":"1995","unstructured":"Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH (1995) B7\u20131 and B7\u20132 co-stimulatory molecules activate differentially the TH1\/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707\u2013718","journal-title":"Cell"},{"key":"7_CR74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0167-5699(92)90158-4","volume":"13","author":"CF Kuper","year":"1992","unstructured":"Kuper CF, Koornstra PJ, Hameleers DM, Biewenga J, Spit DJ, Duijvestijn AM, van Breda Vriesman PJ, Sminia T (1992) The role of nasopharyngeal lymphoid tissue. Immunol Today 13:219\u2013224","journal-title":"Immunol Today"},{"key":"7_CR75","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/0016-5085(91)90397-4","volume":"101","author":"K Kusugami","year":"1991","unstructured":"Kusugami K, Matsuura T, West GA, Youngman KR, Rachmilewitz D, Fiocchi C (1991) Loss of in- terleukin-2-producing intestinal CD4+ T cells in inflammatory bowel disease. Gastroenterology. 101:1594\u20131605","journal-title":"Gastroenterology"},{"key":"7_CR76","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1002\/eji.1830241226","volume":"24","author":"AS Lagoo","year":"1994","unstructured":"Lagoo AS, Eldridge JH, Lagoo-Deenadaylan S, Black CA, Ridwan BU, Hardy KJ, McGhee JR, Beagley KW (1994) Peyer\u2019s patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion. Eur J Immunol 24:3087\u20133092","journal-title":"Eur J Immunol"},{"key":"7_CR77","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.4049\/jimmunol.138.10.3375","volume":"138","author":"L Lefrancois","year":"1987","unstructured":"Lefrancois L (1987) Carbohydrate differentiation antigens of murine T cells: expression on intestinal lymphocytes and intestinal epithelium. J Immunol 138:3375\u20133384","journal-title":"J Immunol"},{"key":"7_CR78","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4049\/jimmunol.159.2.538","volume":"159","author":"L Lefrancois","year":"1997","unstructured":"Lefrancois L, Olson S (1997) Reconstitution of the extrathymic intestinal T cell compartment in the absence of irradiation. J Immunol 159:538\u2013541","journal-title":"J Immunol"},{"key":"7_CR79","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0167-5699(95)80065-4","volume":"16","author":"L Lefrancois","year":"1995","unstructured":"Lefrancois L, Puddington L (1995) Extrathymic T-cell development: virtual reality? Immunol Today 16:16\u201321","journal-title":"Immunol Today"},{"key":"7_CR80","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.184.2.597","volume":"184","author":"O Liesenfeld","year":"1996","unstructured":"Liesenfeld O, Kosek J, Remington JS, Suzuki Y (1996) Association of CD4+ T cell-dependent, inter- feron-\u03b3-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J Exp Med 184:597\u2013607","journal-title":"J Exp Med"},{"key":"7_CR81","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1084\/jem.178.1.187","volume":"178","author":"KE Lundin","year":"1993","unstructured":"Lundin KE, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM (1993) Gliadin specific, HLA-DQ ((*0501*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 178:187\u2013196","journal-title":"J Exp Med"},{"key":"7_CR82","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.4049\/jimmunol.157.5.1926","volume":"157","author":"C Lundqvist","year":"1996","unstructured":"Lundqvist C, Melgar S, Yeung M-W, Hammarstrom S, Hammarstrom M-L (1996) Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggests T helper 1 and cytotoxic functions. J Immunol 157:1926\u20131934","journal-title":"J Immunol"},{"key":"7_CR83","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/eji.1830250502","volume":"25","author":"S Lynch","year":"1995","unstructured":"Lynch S, Kelleher D, McManus R, O\u2019Farrelly C (1995) RAG1 and RAG2 expression in human intestinal epithelium:evidence of extrathymic T cell differentiation. Eur J Immunol 25:1143\u20131147","journal-title":"Eur J Immunol"},{"key":"7_CR84","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1365-2249.1996.50755.x","volume":"104","author":"CG Ma","year":"1996","unstructured":"Ma CG, Zhang GX, Xiao BG, Link H (1996) Cellular mRNA expression of interferon-gamma (IFN- gamma), IL-4 and transforming growth factor-beta (TGF-beta) in rats nasally tolerised against experimental autoimmune myasthenia gravis (EAMG). Clin Exp Immunol 104:509\u2013516","journal-title":"Clin Exp Immunol"},{"key":"7_CR85","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/00042737-199711000-00005","volume":"9","author":"TT MacDonald","year":"1997","unstructured":"MacDonald TT (1997) Cytokine gene deleted mice in the study of gastrointestinal inflammation. Eur J Gastoenterol Hepatol 9:1051\u20131055","journal-title":"Eur J Gastoenterol Hepatol"},{"key":"7_CR86","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.4049\/jimmunol.155.10.4621","volume":"155","author":"M Marinaro","year":"1995","unstructured":"Marinaro M, Staats HF, Hiroi T, Jackson RJ, Coste M, Boyaka PN, Okahashi N, Yamamoto M, Kiyono H, Bluethmann H, Fujihashi K, McGhee JR (1995) Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol 155:4621\u20134629","journal-title":"J Immunol"},{"key":"7_CR87","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/intimm\/5.9.1159","volume":"5","author":"B Metzler","year":"1993","unstructured":"Metzler B, Wraith DC (1993) Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of encephalitogenic peptide: influence of MHC binding affinity. Int Immunol 5:1159\u20131165","journal-title":"Int Immunol"},{"key":"7_CR88","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1084\/jem.174.4.791","volume":"174","author":"A Miller","year":"1991","unstructured":"Miller A, Lider O, Weiner HL (1991) Antigen-driven bystander suppression after oral administration of antigens. J Exp Med 174:791\u2013798","journal-title":"J Exp Med"},{"key":"7_CR89","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1073\/pnas.89.1.421","volume":"89","author":"A Miller","year":"1992","unstructured":"Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL (1992) Suppressor T cell generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor (3 after antigen-specific triggering. Proc Natl Acad Sci USA 89:421\u2013425","journal-title":"Proc Natl Acad Sci USA"},{"key":"7_CR90","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1084\/jem.183.3.847","volume":"183","author":"A Mizoguchi","year":"1996","unstructured":"Mizoguchi A, Mizoguchi E, Chiba C, Spiekermann GM, Tonegawa S, Nagler-Anderson C, Bhan AK (1996) Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease. J Exp Med 183:847\u2013856","journal-title":"J Exp Med"},{"key":"7_CR91","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0016-5085(97)70128-8","volume":"112","author":"G Monteleone","year":"1997","unstructured":"Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, Pallone F (1997) Interleukin 12 is expressed and actively released by Crohn\u2019s disease intestinal lamina propria mononuclear cells. Gastroenterology 112:1169\u20131178","journal-title":"Gastroenterology"},{"key":"7_CR92","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0167-5699(87)90853-X","volume":"8","author":"AM Mowat","year":"1987","unstructured":"Mowat AM (1987) The regulation of immune responses to dietary protein antigens. Immunol Today 1987 8:93\u201398","journal-title":"Immunol Today"},{"key":"7_CR93","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/0016-5085(92)91722-G","volume":"102","author":"GE Mullin","year":"1992","unstructured":"Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SP (1992) Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn\u2019s disease but not ulcerative colitis. Gastroenterology 102:1620\u20131627","journal-title":"Gastroenterology"},{"key":"7_CR94","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1084\/jem.182.5.1281","volume":"182","author":"MF Neurath","year":"1995","unstructured":"Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W (1995) Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 182:1281\u20131290","journal-title":"J Exp Med"},{"key":"7_CR95","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1084\/jem.183.6.2605","volume":"183","author":"MF Neurath","year":"1996","unstructured":"Neurath MF, Fuss I, Kelsall BL, Presky DH, Waegell W, Strober W (1996) Experimental granulomatous colitis in mice is abrogated by induction of TGF#x03B2;-mediated oral tolerance. J Exp Med 183:2605\u20132616","journal-title":"J Exp Med"},{"key":"7_CR96","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/eji.1830270722","volume":"27","author":"MF Neurath","year":"1997","unstructured":"Neurath MF, Fuss I, Pasparakis M, Alexapoulou L, Haralambous S, Meyer zum Buschenfelde KH, Strober W, Kollias G (1997) Predominant pathogenic role of tumor necrosis factor in experimental colitis. Eur J Immunol 27:1743\u20131750","journal-title":"Eur J Immunol"},{"key":"7_CR97","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2249.1995.tb03130.x","volume":"101","author":"M Niessner","year":"1995","unstructured":"Niessner M, Volk BA (1995) Altered Thl\/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 101:428\u2013435","journal-title":"Clin Exp Immunol"},{"key":"7_CR98","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/gut.37.6.766","volume":"37","author":"EM Nilsen","year":"1995","unstructured":"Nilsen EM, Lundin KEA, Krajci P, Scott H, Sollid LM, Brandtzaeg P (1995) Gluten-specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Thl or Th0 profile dominated by interferon-\u03b3. Gut 37:766\u2013776","journal-title":"Gut"},{"key":"7_CR99","first-page":"823","volume":"150","author":"P Parronchi","year":"1997","unstructured":"Parronchi P, Romagnani P, Annunziato F, Sampognaro S, Becchio A, Giannarini L, Maggi E, Pupilli C, Tonelli F, Romagnani S (1997) Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn\u2019s disease. Am J Pathol 150:823\u2013832","journal-title":"Am J Pathol"},{"key":"7_CR100","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4049\/jimmunol.158.4.1582","volume":"158","author":"SLF Pender","year":"1997","unstructured":"Pender SLF, Tickle SP, Docherty AJP, Howie D, Wathen NC, MacDonald TT (1997) A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 158:1582\u20131590","journal-title":"J Immunol"},{"key":"7_CR101","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.4049\/jimmunol.160.8.4098","volume":"160","author":"SLF Pender","year":"1998","unstructured":"Pender SLF, Fell JMC, Chamow SM, Ashkenazi A, MacDonald TT (1998) A p55 tumor necrosis factor (TNF) receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix me- talloproteinase production. J Immunol 160:4098\u2013103","journal-title":"J Immunol"},{"key":"7_CR102","first-page":"212","volume":"86","author":"LM Penney","year":"1995","unstructured":"Penney LM, Kilshaw PJ, MacDonald TT (1995) Regional variation in the proliferative rate and lifespan of alpha beta TCR+ and gamma delta TCR+ intraepithelial lymphocytes in the murine small intestine. Immunology 86:212\u2013218","journal-title":"Immunology"},{"key":"7_CR103","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1084\/jem.176.1.187","volume":"176","author":"P Poussier","year":"1992","unstructured":"Poussier P, Edouard P, Lee C, Binnie M, Julius M (1992) Thymus-independent development and negative selection of T cells expressing T cell receptor alpha\/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut-and thymus-derived T lymphocytes. J Exp Med 176:187\u2013199","journal-title":"J Exp Med"},{"key":"7_CR104","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.179.2.589","volume":"179","author":"F Powrie","year":"1994","unstructured":"Powrie F, Correa-Oliveira R, Mauze S, Coifman RL (1994a) Regulatory interactions between CD45RBhigh and CD45RBIow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 179:589\u2013600","journal-title":"J Exp Med"},{"key":"7_CR105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/1074-7613(94)90045-0","volume":"1","author":"F Powrie","year":"1994","unstructured":"Powrie F, Leach MW, Mauze S, Menon S, Caddie LB, Coffman RL (1994b) Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1:553\u2013562","journal-title":"Immunity"},{"key":"7_CR106","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1084\/jem.183.6.2669","volume":"183","author":"F Powrie","year":"1996","unstructured":"Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL (1996) A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 183:2669\u20132674","journal-title":"J Exp Med"},{"key":"7_CR107","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0016-5085(97)70030-1","volume":"112","author":"J Rugtveidt","year":"1997","unstructured":"Rugtveidt J, Nilsen EM, Bakka A, Carlsen H, Brandtzaeg P, Scott H (1997) Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease Gastroenterology 112:1493\u20131505","journal-title":"Gastroenterology"},{"key":"7_CR108","first-page":"519","volume":"148","author":"UK Saarialho-Kere","year":"1996","unstructured":"Saarialho-Kere UK, Vaalamo M, Puolakkainen P, Airola K, Parks WC, Karjalainen-Lindsberg ML (1996) Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers. Am J Pathol 148:519\u2013526","journal-title":"Am J Pathol"},{"key":"7_CR109","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/eji.1830270727","volume":"27","author":"A Saparov","year":"1997","unstructured":"Saparov A, Elson CO, Devore-Carter D, Bucy RP, Weaver CT (1997) Single cell analyses of CD4+ T cells from \u03b1\u03b2 T cell receptor transgenic mice: a distinct mucosal cytokine phenotype in the absence of transgene-specific antigen. Eur J Immunol 27:1774\u20131781","journal-title":"Eur J Immunol"},{"key":"7_CR110","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.4049\/jimmunol.149.8.2816","volume":"149","author":"HL Schieferdecker","year":"1992","unstructured":"Schieferdecker HL, Ullrich R, Hirseland H, Zeitz M (1992) T cell differentiation antigens on lymphocytes in the human intestinal lamina propria. J Immunol 149:2816\u20132822","journal-title":"J Immunol"},{"key":"7_CR111","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/eji.1830270104","volume":"27","author":"SJ Simpson","year":"1997","unstructured":"Simpson SJ, Hollander GA, Mizoguchi E, Allen D, Bhan AK, Wang B, Terhorst C (1997) Expression of pro-inflammatory cytokines by TCR \u03b1#x03B2; + and TCR \u03b3\u03b4 + T cells in an experimental model of colitis. Eur J Immunol 27:17\u201325","journal-title":"Eur J Immunol"},{"key":"7_CR112","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2249.1991.tb05690.x","volume":"85","author":"J Spencer","year":"1991","unstructured":"Spencer J, Isaacson P, MacDonald TT, Thomas AJ, Walker-Smith J A (1991) Gamma\/delta T cells and the diagnosis of coeliac disease. Clin Exp Immunol 85:109\u2013113","journal-title":"Clin Exp Immunol"},{"key":"7_CR113","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1365-2249.1996.tb08289.x","volume":"103","author":"NA Staines","year":"1996","unstructured":"Staines NA, Harper N, Ward FJ, Malmstrom V, Holmdahl R, Bansal S (1996) Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184\u2013198 of bovine type II collagen (CII) expressing a dominant T cell epitope. Clin Exp Immunol 103:368\u2013375","journal-title":"Clin Exp Immunol"},{"key":"7_CR114","first-page":"16","volume":"5","author":"HF Staats","year":"1997","unstructured":"Staats HF (1997) Intranasal immunisation with carrier-free synthetic peptides. Mucosal Immunol Update 5:16\u201320","journal-title":"Mucosal Immunol Update"},{"key":"7_CR115","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4049\/jimmunol.145.1.68","volume":"145","author":"T Taguchi","year":"1990","unstructured":"Taguchi T, McGhee JR, Coffman RL, Beagley KW, Eldridge JH, Takatsu K, Kiyono H (1990) Analysis of Thl and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-\u03b3 and IL-5. J Immunol 145:68\u201377","journal-title":"J Immunol"},{"key":"7_CR116","first-page":"8","volume":"5","author":"S Tamura","year":"1997","unstructured":"Tamura S, Kurata T (1997) Intranasal immunization for human application. Mucosal Immunol Update 5:8\u201310","journal-title":"Mucosal Immunol Update"},{"key":"7_CR117","doi-asserted-by":"crossref","first-page":"664","DOI":"10.4049\/jimmunol.154.2.664","volume":"154","author":"SR Targan","year":"1995","unstructured":"Targan SR, Deem DL, Liu M, Wang S, Nel A (1995) Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol 154:664\u2013675","journal-title":"J Immunol"},{"key":"7_CR118","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199710093371502","volume":"337","author":"SR Targan","year":"1997","unstructured":"Targan SR, Hanauer SB, VanDeventer SJH, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ (1997) A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor \u03b1 (for Crohn\u2019s disease. New Engl J Med 337:1029\u20131035","journal-title":"New Engl J Med"},{"key":"7_CR119","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1084\/jem.183.4.1561","volume":"183","author":"J Tian","year":"1996","unstructured":"Tian J, Atkinson MA, Clare-Salzer M, Herschenfeld A, Forsthuber T, Lehmann PV, Kaufman DL (1996) Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183:1561\u20131567","journal-title":"J Exp Med"},{"key":"7_CR120","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1126\/science.8378772","volume":"261","author":"DE Trentham","year":"1993","unstructured":"Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL (1993) Effects of oral administration of type II collagen on rheumatoid arthritis. Science 261:1727\u20131730","journal-title":"Science"},{"key":"7_CR121","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.181.1.41","volume":"181","author":"M Vajdy","year":"1995","unstructured":"Vajdy M, Kosco-Vilbois MH, Kopf M, Kohler G, Lycke N (1995) Inpaired mucosal immune responses in interleukin-4 targeted mice. J Exp Med 181:41\u201353","journal-title":"J Exp Med"},{"key":"7_CR122","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.4049\/jimmunol.156.4.1504","volume":"156","author":"JL Cott Van","year":"1996","unstructured":"Van Cott JL, Staats HF, Pasual DW, Roberts M, Chatfield SN, Yamamoto M, Coste M, Carter PB, Kiyono H, McGhee JR (1996) Regulation of mucosal and systemic antibody responses by T helper subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J Immunol 156:1504\u20131514","journal-title":"J Immunol"},{"key":"7_CR123","first-page":"583","volume":"66","author":"J Viney","year":"1989","unstructured":"Viney J, MacDonald TT, Kilshaw PJ (1989) T cell receptor expression in intestinal intraepithelial lymphocyte subpopulations of normal and athymic mice. Immunology 66:583\u2013587","journal-title":"Immunology"},{"key":"7_CR124","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/eji.1830200734","volume":"20","author":"JL Viney","year":"1990","unstructured":"Viney JL, Kilshaw PK, MacDonald TT (1990) Cytotoxic \u03b1\u00df \u03b3\u03b4 T cells in murine intestinal epithelium. Eur J Immunol 20:1623\u20131626","journal-title":"Eur J Immunol"},{"key":"7_CR125","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1172\/JCI118002","volume":"95","author":"M Watanabe","year":"1995","unstructured":"Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, Aiso S, Hibi T, Ishii H (1995) Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest 95:2495\u20132953","journal-title":"J Clin Invest"},{"key":"7_CR126","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0167-5699(97)01053-0","volume":"19","author":"HL Weiner","year":"1997","unstructured":"Weiner HL (1997) Oral tolerance: immune mechanisms and treatment of autoimmune disease. Immunol Today 19:335\u2013343","journal-title":"Immunol Today"},{"key":"7_CR127","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.7680493","volume":"259","author":"HL Weiner","year":"1993","unstructured":"Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM, Hafler DA (1993) Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 259:1321\u20131324","journal-title":"Science"},{"key":"7_CR128","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1053\/gast.1996.v110.pm8964392","volume":"110","author":"GA West","year":"1996","unstructured":"West GA, Matsuura T, Levine AD, Klein JS, Fiocchi C (1996) Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity. Gastroenterology 110:1683\u20131695","journal-title":"Gastroenterology"},{"key":"7_CR129","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1002\/eji.1830211007","volume":"21","author":"AD Wilson","year":"1991","unstructured":"Wilson AD, Bailey M, Williams NA, Stokes CR (1991) The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant. Eur J Immunol 21:2333\u20132339","journal-title":"Eur J Immunol"},{"key":"7_CR130","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/intimm\/4.4.433","volume":"4","author":"J Xu-Amanu","year":"1992","unstructured":"Xu-Amanu J, Aicher WK, Taguchi T, Kiyono H, McGhee JR (1992) Selective induction of Th2 cells in murine Peyer\u2019s patches by oral immunisation. Int Immunol 4:433\u2013445","journal-title":"Int Immunol"},{"key":"7_CR131","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1084\/jem.178.4.1309","volume":"178","author":"J Xu-Amanu","year":"1993","unstructured":"Xu-Amanu J, Kiyono H, Jackson RJ, Staats HF, Fujihashi K, Burrows PD, Elson CO, Pillai S, McGhee JR (1993) Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 178:1309\u20131320","journal-title":"J Exp Med"},{"key":"7_CR132","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1128\/IAI.61.5.2154-2161.1993","volume":"61","author":"S Yamamoto","year":"1993","unstructured":"Yamamoto S, Russ F, Teixeira HC, Conradt P, Kaufmann SH (1993) Listeria monocytogenes-inducedy-interferon secretion by intestinal intraepithelial lymphocytes. Infect Immun 61:2154\u20132161","journal-title":"Infect Immun"},{"key":"7_CR133","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1073\/pnas.94.10.5267","volume":"94","author":"S Yamamoto","year":"1997","unstructured":"Yamamoto S, Kiyono H, Yamamoto M, Imaoka K, Fujihashi K, Van Ginkel FW, N\u00f6da M, Takeda Y, McGhee JR (1997) A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sei USA 94:5267\u20135272","journal-title":"Proc Natl Acad Sei USA"}],"container-title":["Current Topics in Microbiology and Immunology","Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-59951-4_7.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T17:38:47Z","timestamp":1686332327000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-59951-4_7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"ISBN":["9783642641947","9783642599514"],"references-count":133,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-59951-4_7","relation":{},"ISSN":["0070-217X"],"issn-type":[{"type":"print","value":"0070-217X"}],"subject":[],"published":{"date-parts":[[1999]]}}}