{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T04:09:50Z","timestamp":1741925390825,"version":"3.38.0"},"publisher-location":"Berlin, Heidelberg","reference-count":47,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783540122043"},{"type":"electronic","value":"9783642689703"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983]]},"DOI":"10.1007\/978-3-642-68970-3_5","type":"book-chapter","created":{"date-parts":[[2011,10,22]],"date-time":"2011-10-22T05:36:20Z","timestamp":1319261780000},"page":"59-74","source":"Crossref","is-referenced-by-count":9,"title":["Biochemical Modulation of Blood-Brain Barrier Permeability"],"prefix":"10.1007","author":[{"given":"A.","family":"Gjedde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch.","family":"Crone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"5_CR1","first-page":"333","volume":"49","author":"L Michaelis","year":"1913","unstructured":"Michaelis L, Menten ML (1913) Die Kinetik der Invertinwirkung. Biochem Z 49: 333\u2013369","journal-title":"Biochem Z"},{"key":"5_CR2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0031-6997(25)07001-2","volume":"13","author":"PP LeFevre","year":"1961","unstructured":"LeFevre PP (1961) Sugar transport in the red blood cell: Structure-activity relationships in substrates and antagonists. Pharmacol Rev 13: 39\u201370","journal-title":"Pharmacol Rev"},{"key":"5_CR3","first-page":"257","volume-title":"Membrane transport in red cells","author":"RJ Naftalin","year":"1977","unstructured":"Naftalin RJ, Holman GD (1977) Transport of sugars in human red cells. In: Ellory JC, Lew VL (eds) Membrane transport in red cells. Academic Press, New York, pp 257\u2013299"},{"key":"5_CR4","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/j.1748-1716.1963.tb02652.x","volume":"58","author":"C Crone","year":"1963","unstructured":"Crone C (1963) The permeability of capillaries in various organs as determined by use of the \u2018indicator diffusion method\u2019. Acta physiol scand 58: 292\u2013305","journal-title":"Acta physiol scand"},{"key":"5_CR5","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/0006-8993(70)90123-X","volume":"24","author":"WH Oldendorf","year":"1970","unstructured":"Oldendorf WH (1970) Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. Brain Res 24: 372\u2013376","journal-title":"Brain Res"},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1748-1716.1980.tb06540.x","volume":"108","author":"A Gjedde","year":"1980","unstructured":"Gjedde A, Hansen AJ, Siemkowicz E (1980) Rapid simultaneous determination of regional blood flow and blood-brain glucose transfer in brain of rat. Acta physiol scand 108: 321\u2013330","journal-title":"Acta physiol scand"},{"key":"5_CR7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/j.1748-1716.1980.tb06541.x","volume":"108","author":"A Gjedde","year":"1980","unstructured":"Gjedde A (1980) Rapid steady-state analysis of blood-brain glucose transfer in rat. Acta physiol scand 108: 331\u2013339","journal-title":"Acta physiol scand"},{"key":"5_CR8","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/BF00254490","volume":"20","author":"WM Pardridge","year":"1981","unstructured":"Pardridge WM (1981) Transport of nutrients and hormones through the blood-brain barrier. Diabetologia 20: 246\u2013254","journal-title":"Diabetologia"},{"key":"5_CR9","first-page":"916","volume":"28897-","author":"L Sokoloff","year":"1977","unstructured":"Sokoloff L, Reivich M, Kennedy C, des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara O (1977) The [14c]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anaesthetized albino rat. J Neurochem 28: 897\u2013916","journal-title":"J Neurochem"},{"key":"5_CR10","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1748-1716.1977.tb06027.x","volume":"101","author":"AJ Hansen","year":"1977","unstructured":"Hansen AJ, Lund-Andersen H, Crone C (1977) K+-permeability of blood-brain barrier, investigated by aid of K+-sensitive microelectrode. Acta physiol scand 101: 438\u2013445","journal-title":"Acta physiol scand"},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1111\/j.1471-4159.1981.tb00587.x","volume":"36","author":"A Gjedde","year":"1981","unstructured":"Gjedde A (1981a) High and low affinity transport of D-glucose from blood to brain. J Neurochem 36: 1463\u20131471","journal-title":"J Neurochem"},{"key":"5_CR12","first-page":"251","volume":"2","author":"C Font","year":"1981","unstructured":"Font C, Campos MG, Hansen AJ, Siemkowicz E, Crone C, Gjedde A (1981) Constantes de difusion del inositol en cerebro de ratas. Fed Espan Soc Biol Exp 2: 251","journal-title":"Fed Espan Soc Biol Exp"},{"key":"5_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000137466","volume":"22","author":"JH James","year":"1981","unstructured":"James JH, Fischer JE (1981) Transport of neutral amino acids at the blood-brain barrier. Pharmacol 22: 1\u20137","journal-title":"Pharmacol"},{"key":"5_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0070-2161(08)60859-X","volume-title":"Current topics in membranes and transport (Vol 7)","author":"PG LeFevre","year":"1975","unstructured":"LeFevre PG (1975) The present state of the carrier hypothesis. In: Bronner F, Kleinzeller A (eds) Current topics in membranes and transport (Vol 7). Academic Press, New York, pp 109\u2013215"},{"key":"5_CR15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1042\/bj1800677","volume":"180","author":"JE Cremer","year":"1979","unstructured":"Cremer JE, Cunningham VJ (1979) Effects of some chlorinated sugar derivatives on the hexose transport system of the blood-brain barrier. Biochem J 180: 677\u2013679","journal-title":"Biochem J"},{"key":"5_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/0005-2736(75)90279-5","volume":"382","author":"WM Pardridge","year":"1975","unstructured":"Pardridge WM, Oldendorf WH (1975) Kinetics of blood-brain barrier transport of hexoses. Biochim Piophys Acta 382: 377\u2013392","journal-title":"Biochim Piophys Acta"},{"key":"5_CR17","first-page":"E492","volume":"232","author":"WM Pardridge","year":"1977","unstructured":"Pardridge WM (1977) Unidirectional influx of glutamine and other neutral amino acids into liver of fed and fasted rat in vivo. Am J Physiol 232: E492\u2013E496","journal-title":"Am J Physiol"},{"key":"5_CR18","volume-title":"A review of amino acid transport processes in animal cells and tissues","author":"J Lerner","year":"1978","unstructured":"Lerner J (1978) A review of amino acid transport processes in animal cells and tissues. University of Maine at Orono Press, Orono"},{"key":"5_CR19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/ajplegacy.1975.229.5.1165","volume":"229","author":"A Gjedde","year":"1975","unstructured":"Gjedde A, Crone C (1975) Induction processes in blood-brain transfer of ketone bodies during starvation. Am J Physiol 229: 1165\u20131169","journal-title":"Am J Physiol"},{"key":"5_CR20","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1126\/science.7027439","volume":"214","author":"A Gjedde","year":"1981","unstructured":"Gjedde A, Crone C (1981) Blood-brain glucose transfer: Repression in chronic hyperglycemia. Science 214: 456\u2013457","journal-title":"Science"},{"key":"5_CR21","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/0005-2736(75)90240-0","volume":"401","author":"AL Betz","year":"1975","unstructured":"Betz AL, Gilboe DD, Drewes LR (1975) Accelerative exchange diffusion kinetics of glucose between blood and brain and its relation to transport during anoxia. Biochim Biophys Acta 401: 416\u2013428","journal-title":"Biochim Biophys Acta"},{"key":"5_CR22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1748-1716.1982.tb07070.x","volume":"115","author":"O Christensen","year":"1982","unstructured":"Christensen O, Lund-Andersen H, Betz AL, Gilboe DD (1982) Transport of glucose across the blood-brain barrier: Re-evaluation of the accelerative exchange diffusion. Acta physiol scand 115: 233\u2013238","journal-title":"Acta physiol scand"},{"key":"5_CR23","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1126\/science.663619","volume":"200","author":"JH James","year":"1978","unstructured":"James JH, Escourrou J, Fischer JE (1978) Blood-brain neutral amino acid transport activity is increased after portacaval anastomosis. Science 200: 1395\u20131397","journal-title":"Science"},{"key":"5_CR24","first-page":"Gl63","volume":"24l","author":"P-M Huet","year":"1981","unstructured":"Huet P-M, Pomier-Layrargues G, Duguay L, du Souich P (1981) Blood-brain transport of tryptophan and phenylalanine: Effect of portacaval shunt in dogs. Am J Physiol 24l: Gl63\u2013Gl69","journal-title":"Am J Physiol"},{"key":"5_CR25","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1111\/j.1471-4159.1980.tb09013.x","volume":"35","author":"A Gjedde","year":"1980","unstructured":"Gjedde A, Rasmussen M (1980) Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. J Neurochem 35: 1382\u20131387","journal-title":"J Neurochem"},{"key":"5_CR26","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0006-8993(81)90782-4","volume":"221","author":"JE Cremer","year":"1981","unstructured":"Cremer JE, Ray DE, Sarna GS, Cunningham VJ (1981) A study of the kinetic behaviour of glucose based on simultaneous estimates of influx and phosphorylation in brain regions of rats in different physiological states. Brain Res 221: 331\u2013342","journal-title":"Brain Res"},{"key":"5_CR27","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1111\/j.1471-4159.1981.tb04465.x","volume":"37","author":"A Gjedde","year":"1981","unstructured":"Gjedde A, Hansen AJ, Quistorff B (1981) Blood-brain glucose transfer in spreading depression. J Neurochem 37: 807\u2013812","journal-title":"J Neurochem"},{"key":"5_CR28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/ajplegacy.1975.229.1.215","volume":"229","author":"WW Eckman","year":"1975","unstructured":"Eckman WW, Phair RD, Fenstermacher JD, Patlak CS, Kennedy C, Sokoloff L (1975) Permeability limitation in estimation of local brain blood flow with [14c]antipyrine. Am J Physiol 229: 215\u2013221","journal-title":"Am J Physiol"},{"key":"5_CR29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1365-2362.1977.tb01578.x","volume":"7","author":"TG Bolwig","year":"1977","unstructured":"Bolwig TG, Hertz MM, Paulson OB, Spotoft H, Rafaelsen OJ (1977a) The permeability of the blood-brain barrier during electrically induced seizures in man. Europ J Clin Invest 7: 87\u201393","journal-title":"Europ J Clin Invest"},{"key":"5_CR30","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-2362.1977.tb01579.x","volume":"7","author":"TG Bolwig","year":"1977","unstructured":"Bolwig TG, Hertz MM, Holm-Jensen J (1977b) Blood-brain barrier permeability during electroshock seizures in the rat. Europ Clin Invest 7: 95\u2013100","journal-title":"Europ Clin Invest"},{"key":"5_CR31","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/BF00637105","volume":"4","author":"G Behnsen","year":"1927","unstructured":"Behnsen G (1927) Ober die Farbstoffspeicherung im Zentralnervensystem der weissen Maus in verschiedenen Alterzust\u00e4nden. Z Zellforsch Mikr Anat 4: 513\u2013572","journal-title":"Z Zellforsch Mikr Anat"},{"key":"5_CR32","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1203\/00006450-198201001-00008","volume":"16","author":"J Hellmann","year":"1982","unstructured":"Hellmann J, Vannucci RC, Nardis EE (1982) Blood-brain barrier permeability to lactic acid in the newborn dog: Lactate as a cerebral metabolic fuel. Pediatr Res 16: 40\u201344","journal-title":"Pediatr Res"},{"key":"5_CR33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0140-6736(82)90257-4","volume":"I","author":"J Fernandes","year":"1982","unstructured":"Fernandes J, Berger R, Smit GPA (1982) Lactate as energy source for brain in glucose-6-phosphatase deficient child. Lancet I: 113","journal-title":"Lancet"},{"key":"5_CR34","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1471-4159.1979.tb05173.x","volume":"33","author":"JE Cremer","year":"1979","unstructured":"Cremer JE, Cunningham VJ, Pardridge WM, Braun LD, Oldendorf WH (1979) Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats. J Neurochem 33: 439\u2013446","journal-title":"J Neurochem"},{"key":"5_CR35","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1203\/00006450-198204000-00017","volume":"16","author":"EM Cornford","year":"1982","unstructured":"Cornford EM, Braun LD, Oldendorf WH (1982) Developmental modulations of blood-brain barrier permeability as an indicator of changing nutritional requirements in the brain. Pediatr Res 16: 324\u2013328","journal-title":"Pediatr Res"},{"key":"5_CR36","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1111\/j.1471-4159.1982.tb05335.x","volume":"38","author":"WM Pardridge","year":"1982","unstructured":"Pardridge, WM, Mietus LJ (1982) Kinetics of neutral amino acid transport through the blood-brain barrier of the newborn rabbit. J Neurochem 38: 955\u2013962","journal-title":"J Neurochem"},{"key":"5_CR37","first-page":"307","volume":"7","author":"A Gjedde","year":"1981","unstructured":"Gjedde A (1981b) Regulation and adaptation of substrate transport to brain. Adv Physiol Sci 7: 307\u2013315","journal-title":"Adv Physiol Sci"},{"key":"5_CR38","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/S0140-6736(79)92119-6","volume":"II","author":"JH James","year":"1979","unstructured":"James JH, Ziparo V, Jeppson B, Fischer JE (1979) Hyperammonemia, plasma amino acid imbalance, and blood-brain amino acid transport: A unified theory of portal-systemic encephalopathy. Lancet II: 772\u2013775","journal-title":"Lancet"},{"key":"5_CR39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/archneur.1973.00490190063008","volume":"28","author":"WH Oldendorf","year":"1973","unstructured":"Oldendorf WH (1973) Saturation of blood-brain barrier transport of amino acids in phenyl ketonuria. Arch Neurol 28: 45\u201348","journal-title":"Arch Neurol"},{"key":"5_CR40","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1111\/j.1471-4159.1982.tb07945.x","volume":"39","author":"JE Cremer","year":"1982","unstructured":"Cremer JE, Teal HM, Cunningham VJ (1982) Inhibition, by 2-oxo acids that accumulate in maple-syrup-urine disease, of lactate, pyruvate, and 3-hydroxybutyrate transport across the blood-brain barrier. J Neurochem 39: 674\u2013677","journal-title":"J Neurochem"},{"key":"5_CR41","first-page":"44P","volume":"305","author":"PM Daniel","year":"1980","unstructured":"Daniel PM, Love ER, Pratt OE (1980) Inhibition of glucose transport into the brains of suckling rats by raising the level of galactose in the blood. J Physiol (Lond) 305: 44P\u201345P","journal-title":"J Physiol (Lond)"},{"key":"5_CR42","first-page":"602","volume":"11","author":"BD Wyke","year":"1959","unstructured":"Wyke BD (1959) Electroencephalographic studies in the syndrome of relative cerebral hypoglycaemia. Electroenceph Clin Neurophysiol 11: 602","journal-title":"Electroenceph Clin Neurophysiol"},{"key":"5_CR43","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0165-0173(82)90018-2","volume":"4","author":"A Gjedde","year":"1982","unstructured":"Gjedde A (1982) Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: A re-examination. Brain Res Rev 4: 237\u2013274","journal-title":"Brain Res Rev"},{"key":"5_CR44","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1111\/j.1471-4159.1981.tb06322.x","volume":"37","author":"JM Bertoni","year":"1981","unstructured":"Bertoni JM (1981) Competitive inhibition of rat brain hexokinase by 2-deoxyglucose, glucosamine, and metrizamide. J Neurochem 37: 1523\u20131528","journal-title":"J Neurochem"},{"key":"5_CR45","first-page":"319","volume-title":"Advances in experimental medicine: A centenary tribute to Claude Bernard","author":"C Crone","year":"1980","unstructured":"Crone C (1980) Substrate supply to the brain. In: Parvez H, Parvez S (eds) Advances in experimental medicine: A centenary tribute to Claude Bernard. Elsevier\/North-Holland Biomedical Press, Amsterdam, pp 319\u2013349"},{"key":"5_CR46","first-page":"258","volume-title":"Water transport across epithelia (Alfred Benzon Symposium 15)","author":"C Crone","year":"1981","unstructured":"Crone C (1981) Tight and leaky endothelia. In: Ussing HH, Bindslev N, Lassen NA, Sten-Knudsen O (eds) Water transport across epithelia (Alfred Benzon Symposium 15). Munksgaard, Copenhagen, pp 258\u2013267"},{"key":"5_CR47","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0006-8993(82)91227-6","volume":"241","author":"C Crone","year":"1982","unstructured":"Crone C, Olesen SP (1982) Electrical resistance of brain microvascular endothelium. Brain Res 241: 49\u201355","journal-title":"Brain Res"}],"container-title":["Acta Neuropathologica Supplementum","Cerebrovascular Transport Mechanisms"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-68970-3_5.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T05:24:20Z","timestamp":1741843460000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-68970-3_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983]]},"ISBN":["9783540122043","9783642689703"],"references-count":47,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-68970-3_5","relation":{},"ISSN":["0065-1435"],"issn-type":[{"type":"print","value":"0065-1435"}],"subject":[],"published":{"date-parts":[[1983]]}}}