{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:18:27Z","timestamp":1760984307415,"version":"3.40.3"},"publisher-location":"Berlin, Heidelberg","reference-count":32,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783642804625"},{"type":"electronic","value":"9783642804601"}],"license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998]]},"DOI":"10.1007\/978-3-642-80460-1_11","type":"book-chapter","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T01:28:47Z","timestamp":1323221327000},"page":"107-119","source":"Crossref","is-referenced-by-count":47,"title":["Isolated Hepatic Perfusion with Tumor Necrosis Factor \u03b1 and Melphalan: Experimental Studies in Pigs and Phase I Data from Humans"],"prefix":"10.1007","author":[{"given":"M. R.","family":"de Vries","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. H. Borel","family":"Rinkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. H.","family":"van de Velde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Wiggers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A. E. M.","family":"Tollenaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J. K.","family":"Kuppen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L.","family":"Vahrmeijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. M.","family":"Eggermont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"11_CR1","first-page":"5602","volume":"51","author":"D Aderka","year":"1991","unstructured":"Aderka D, Engelmann H, Hornik V, Skornick Y, Levo Y, Wallach D, Kusthai G (1991) Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. Cancer Res 51: 5602\u20135607","journal-title":"Cancer Res"},{"key":"11_CR2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1084\/jem.175.2.323","volume":"175","author":"D Aderka","year":"1992","unstructured":"Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D (1992) Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med 175: 323\u2013329","journal-title":"J Exp Med"},{"key":"11_CR3","first-page":"11","volume":"1","author":"KR Aigner","year":"1988","unstructured":"Aigner KR (1988) Isolated liver perfusion: 5-year-results. Reg Cancer Treat 1: 11\u201320","journal-title":"Reg Cancer Treat"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/bjs.1800760607","volume":"76","author":"SG Archer","year":"1989","unstructured":"Archer SG, Gray BN (1989) Vascularization of small liver metastases. Br J Surg 76: 545\u2013548","journal-title":"Br J Surg"},{"key":"11_CR5","doi-asserted-by":"crossref","unstructured":"B\u00f6rdel Rinkes IHM, De Vries MR, Jonker AM, Swaak TJG, Hack CE, Nooijen PTGA, Wiggers T, Eggermont AMM (1997) Isolated hepatic perfusion in the pig with TNF\u03b1 with and without melphalan. Br J Cancer (in press)","DOI":"10.1038\/bjc.1997.248"},{"key":"11_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/0168-8278(90)90223-E","volume":"11","author":"KJ Busam","year":"1990","unstructured":"Busam KJ, Bauer TM, Bauer J, Gerok W, Decker B (1990) Interleukin-6 release by rat liver macrophages. J Hepatol 11: 367\u2013373","journal-title":"J Hepatol"},{"key":"11_CR7","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1073\/pnas.72.9.3666","volume":"72","author":"EA Carswell","year":"1975","unstructured":"Carswell EA, Old JJ, Kassel RL, Green S, Fiore N, Williamson B (1975) An endotoxin induced serum factor that causes necrosis of tumours. Proc Natl Acad Sci USA 72: 3666\u20133670","journal-title":"Proc Natl Acad Sci USA"},{"key":"11_CR8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0022-4804(88)90041-8","volume":"44","author":"LM Brauw","year":"1988","unstructured":"De Brauw LM, Van de Velde CJH, Tjaden LR, De Bruijn EA, Bell AVRJ, Hermans J, Zwaveling A (1988) In vivo isolated liver perfusion technique in a rat hepatic metastasis model: 5-fluorouracil concentrations in tumor tissue. J Surg Res 44: 137\u2013145","journal-title":"J Surg Res"},{"key":"11_CR9","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/bjc.1994.68","volume":"69","author":"PG Takats","year":"1994","unstructured":"De Takats PG, Kerr DJ, Poole CJ, Warren HW, McArdle CS (1994) Hepatic arterial chemotherapy for metastatic colorectal carcinoma (review). Br J Cancer 69: 372\u2013378","journal-title":"Br J Cancer"},{"key":"11_CR10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00000658-199612000-00011","volume":"224","author":"AMM Eggermont","year":"1996","unstructured":"Eggermont AMM, Schraffordt Koops H, Klausner JM. ( 1996 a) Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience. Ann Surg 224: 756\u2013765","journal-title":"Ann Surg"},{"issue":"S1","key":"11_CR11","first-page":"108","volume":"27","author":"MR Vries","year":"1995","unstructured":"De Vries MR, Borel Rinkes IHM, Buurman WA, Wiggers T, Van de Velde CJH, Eggermont AMM (1995 a) Soluble TNFa receptor induction by isolated hepatic perfusion with TNFa and melphalan. Eur J Surg Res 27(S1):108","journal-title":"Eur J Surg Res"},{"issue":"S1","key":"11_CR12","first-page":"109","volume":"27","author":"MR Vries","year":"1995","unstructured":"De Vries MR, Borel Rinkes IHM, Hack CE, Wiggers T, Van de Velde CJH, Kuppen PJK, Eggermont AMM (1995 b) Isolated hepatic perfusion with TNFa and melphalan: local and systemic effects on secondary cytokine release, coagulation and fibrinolysis. Eur J Surg Res 27(S1):109","journal-title":"Eur J Surg Res"},{"key":"11_CR13","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1200\/JCO.1996.14.10.2653","volume":"14","author":"AMM Eggermont","year":"1996","unstructured":"Eggermont AMM, Schraffordt Koops H, Lienard D, Kroon BBR, Van Geel AN, Hoekstra HJ, Lejeune FJ (1996 b) Isolated limb perfusion with high-dose tumor necrosis factor a in combination with interferon y and melphalan for nonresectable extremity soft tissue sar-comas: a multicenter trial. J Clin Oncol 14: 2653\u20132665","journal-title":"J Clin Oncol"},{"key":"11_CR14","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1200\/JCO.1988.6.8.1328","volume":"6","author":"B Feinberg","year":"1988","unstructured":"Feinberg B, Kurzrock R, Talpaz M et al (1988) A phase I trial of intravenously administered recombinant tumor necrosis factor in patients with advanced cancer. J Clin Oncol 6: 1328\u20131334","journal-title":"J Clin Oncol"},{"key":"11_CR15","first-page":"5","volume":"39","author":"L Genari","year":"1992","unstructured":"Genari L (1992) Liver metastases: a many-sided therapeutical problem. Hepatogastroenterology 39: 5\u20139","journal-title":"Hepatogastroenterology"},{"key":"11_CR16","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1128\/iai.60.7.2835-2842.1992","volume":"60","author":"CE Hack","year":"1992","unstructured":"Hack CE, Hart M, Strack van Schijndel A et al (1992) Interleukin-8 in sepsis: relation to shock and inflammatory mediators. Infect Immunol 60: 2835\u20132842","journal-title":"Infect Immunol"},{"key":"11_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/0022-1759(91)90063-L","volume":"138","author":"M Helle","year":"1991","unstructured":"Helle M, Boeije L, De Groot ER, De Vos A, Aarden LA (1991) Sensitive ELISA for interleukin-6. Detection of IL-6 in biological fluids: synovial fluids and sera. J Immunol Methods 138: 42\u201356","journal-title":"J Immunol Methods"},{"key":"11_CR18","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0022-4804(90)90252-W","volume":"49","author":"MP Kahky","year":"1990","unstructured":"Kahky MP, Daniel CO, Cruz AB, Gaskill HV (1990) Portal infusion of tumor necrosis factor increases mortality in rats. J Surg Res 49: 138\u2013145","journal-title":"J Surg Res"},{"key":"11_CR19","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/S0039-6060(05)80250-8","volume":"117","author":"Y Ku","year":"1995","unstructured":"Ku Y, Fukumoto T, Iwasaki T et al (1995) Clinical pilot study with high-dose intraarterial chemotherapy with direct hemoperfusion under hepatic venous isolation in patients with advanced hepatocellular carcinoma. Surgery 117: 510\u2013519","journal-title":"Surgery"},{"key":"11_CR20","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.4049\/jimmunol.152.8.4036","volume":"152","author":"JFM Leeuwenberg","year":"1994","unstructured":"Leeuwenberg JFM, Jeunhomme TMAA, Buurman WA (1994) Slow release of soluble TNF receptors by monocytes in vitro. J Immunol 152: 4036\u20134043","journal-title":"J Immunol"},{"key":"11_CR21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1200\/JCO.1992.10.1.52","volume":"10","author":"D Lienard","year":"1992","unstructured":"Lienard D, Ewalenko P, Delmotte JJ, Renard N, Lejeune FJ (1992) High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolated perfusion of the limbs for melanoma and sarcoma. J Clin Oncol 10: 50\u201362","journal-title":"J Clin Oncol"},{"key":"11_CR22","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/bjs.1800830438","volume":"83","author":"ER Manusama","year":"1996","unstructured":"Manusama ER, Nooijen PTGA, Stavast J, Durante NMC, Marquet RL, Eggermont AMM (1996) Synergistic antitumor effect of recombinant human tumor necrosis factor a with melphalan in isolated limb perfusion in the rat. Br J Surg 83: 551\u2013555","journal-title":"Br J Surg"},{"key":"11_CR23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/bjc.1991.242","volume":"64","author":"A Marinelli","year":"1991","unstructured":"Marinelli A, Dijkstra FR, Van Dierendonck JH, Kuppen PJK, Cornelisse CJ, Van de Velde CJH (1991) Effectiveness of isolated liver perfusion with mitomycin C in the treatment of liver tumor of rat colorectal cancer. Br J Cancer 64: 74\u201378","journal-title":"Br J Cancer"},{"key":"11_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/bjs.1800810234","volume":"81","author":"FG Que","year":"1994","unstructured":"Que FG, Nagorney DM (1994) Resection of \u2018recurrent\u2019 colorectal metastases to the liver. Br J Surg 81: 255\u2013258","journal-title":"Br J Surg"},{"key":"11_CR25","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/ijc.2910570508","volume":"57","author":"N Renard","year":"1994","unstructured":"Renard N, Lienard D, Lespagnard L, Eggermont AMM, Heimann R, Lejeune FJ (1994) Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumor necrosis factor alpha (TNFa) Int J Cancer 57: 656\u2013663","journal-title":"Int J Cancer"},{"key":"11_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0022-4804(83)90051-3","volume":"34","author":"JL Skibba","year":"1983","unstructured":"Skibba JL, Almagro UA, Condon RE, Petroff RJ Jr (1983) A technique for isolated perfusion of the canine liver with survival. J Surg Res 34: 123\u2013132","journal-title":"J Surg Res"},{"key":"11_CR27","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/jnci\/80.13.1039","volume":"80","author":"DR Spriggs","year":"1988","unstructured":"Spriggs DR, Sherman ML, Micjie H. (1988) Recombinant human tumor necrosis factor administered as a 24-hour intravenous infusion. A phase I and pharmacological study. J Natl Cancer Inst 80: 1039\u20131044","journal-title":"J Natl Cancer Inst"},{"key":"11_CR28","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1159\/000146210","volume":"126","author":"T Strohmeyer","year":"1986","unstructured":"Strohmeyer T, Haugeberg G, Lierse W (1986) Vaskularisation von Lebermetastasen: eine korrosionsanatomische Studie. Acta Anat (Basel) 126: 172\u2013176","journal-title":"Acta Anat (Basel)"},{"key":"11_CR29","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1365-2362.1993.tb00735.x","volume":"23","author":"AJG Swaak","year":"1993","unstructured":"Swaak AJG, Lienard D, Schrafforgt Koops H, Lejeune FJ, Eggermont AMM (1993) Effects of recombinant tumour necrosis factor (rTNFa) in cancer. Observations on the acute phase protein reaction and immunoglobulin synthesis after high dose Rtnf\u03b1 administration in isolated limb perfusions in cancer patients. Eur J Clin Invest 23: 812\u2013818","journal-title":"Eur J Clin Invest"},{"key":"11_CR30","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1365-2362.1992.tb01495.x","volume":"22","author":"G Vreugdenhil","year":"1992","unstructured":"Vreugdenhil G, Lowenberg B, Van Eijk HG, Swaak AJ (1992) Tumor necrosis factor alpha is associated with disease activity and the degree of anemia in patients with rheumatoid arthritis. Eur J Clin Invest 22: 488\u2013493","journal-title":"Eur J Clin Invest"},{"key":"11_CR31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/00000658-198405000-00002","volume":"199","author":"JS Wagner","year":"1984","unstructured":"Wagner JS, Adson MA, Van Heerden JA, Adson MH, Ilstrup DM (1984) The natural history of hepatic metastases from colorectal origin. A comparison with resective treatment. Ann Surg 199: 502\u2013508","journal-title":"Ann Surg"},{"key":"11_CR32","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1200\/JCO.1993.11.3.499","volume":"11","author":"J Weber","year":"1993","unstructured":"Weber J, Yang JC, Topalian SL et al (1993) Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies. J Clin Oncol 11: 499\u2013506","journal-title":"J Clin Oncol"}],"container-title":["Recent Results in Cancer Research","Isolated Liver Perfusion for Hepatic Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-80460-1_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T12:03:03Z","timestamp":1676116983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-642-80460-1_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"ISBN":["9783642804625","9783642804601"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-80460-1_11","relation":{},"ISSN":["0080-0015"],"issn-type":[{"type":"print","value":"0080-0015"}],"subject":[],"published":{"date-parts":[[1998]]}}}