{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:12:28Z","timestamp":1781503948019,"version":"3.54.1"},"publisher-location":"Berlin, Heidelberg","reference-count":26,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540089735","type":"print"},{"value":"9783642812651","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979]]},"DOI":"10.1007\/978-3-642-81265-1_5","type":"book-chapter","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T16:07:34Z","timestamp":1323101254000},"page":"97-107","source":"Crossref","is-referenced-by-count":15,"title":["Structure-Activity Relationships in Glucocorticoids"],"prefix":"10.1007","author":[{"given":"M. E.","family":"Wolff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5_CR1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0025-6196(24)00526-3","volume":"24","author":"PS Hench","year":"1949","unstructured":"Hench, P. S., Kendall, E. C., Slocumb, C. H., Polley, H. F.: The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc. Staff Meetings Mayo Clinic 24, 181\u2013197 (1949).","journal-title":"Proc. Staff Meetings Mayo Clinic"},{"key":"5_CR2","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1021\/ja01105a527","volume":"75","author":"J Fried","year":"1953","unstructured":"Fried, J., Sabo, E. F.: Synthesis of 17\u03b1-hydroxycorticosterone and its 9a-halo derivatives from 11-epi-17\u03b1-hydroxycorticosterone. J. Am. Chem. Soc. 75, 2273\u201374 (1953).","journal-title":"J. Am. Chem. Soc."},{"key":"5_CR3","first-page":"13","volume-title":"Progress in Drug Research","author":"LH Sarett","year":"1963","unstructured":"Sarett, L. H., Patchett, A. A., Steelman, S.: The effects of structural alteration on the antiinflammatory properties of hydroxycortisone. In: Progress in Drug Research. Jucker, E. (ed.) Basel: Birkhauser Verlag 1963, Vol. V, pp. 13\u2013153."},{"key":"5_CR4","volume-title":"Anti-inflammatory Agents","author":"TL Popper","year":"1974","unstructured":"Popper, T. L., Watnick, A. S.: Anti-inflammatory steroids. In: Anti-inflammatory Agents. Scherer, R. A., Whitehouse, M. W. (eds.) New York: Academic Press 1974, Vol. I."},{"key":"5_CR5","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-46262-7","volume-title":"Steroid Protein Interactions","author":"U Westphal","year":"1971","unstructured":"Westphal, U.: Steroid Protein Interactions. New York: Springer 1971."},{"key":"5_CR6","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/BF02670028","volume":"41","author":"U Westphal","year":"1964","unstructured":"Westphal, U.: Binding of steroids to proteins. J. Am. Oil Chem. Soc. 41, 481\u2013490 (1964).","journal-title":"J. Am. Oil Chem. Soc."},{"key":"5_CR7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9258(18)71331-8","volume":"206","author":"KB Eik-Nes","year":"1954","unstructured":"Eik-Nes, K. B., Schellman, J. A., Lumry, C., Samuels, L. T.: The binding of steroids to proteins. I. Solubility determinations. J. Biol. Chem. 206, 411\u2013419 (1954).","journal-title":"J. Biol. Chem"},{"key":"5_CR8","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1016\/S0021-9258(18)69682-6","volume":"234","author":"U Westphal","year":"1959","unstructured":"Westphal, U., Ashley, B. D.: Steroid protein interactions. VI. Stereochemical aspects of interaction between 3-oxo steroids and human serum albumin. J. Biol. Chem. 234, 2847\u20132851 (1959).","journal-title":"J. Biol. Chem."},{"key":"5_CR9","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/0003-9861(67)90390-6","volume":"118","author":"U Westphal","year":"1967","unstructured":"Westphal, U.: Steroid-protein interactions. XIII. Concentrations and binding affinities of corticosteroid-binding globulins in sera of man, monkey, rat, rabbit and guinea pig. Arch. Biochem. Biophys. 118, 556\u2013567 (1967).","journal-title":"Arch. Biochem. Biophys."},{"key":"5_CR10","first-page":"237","volume":"236","author":"JR Florini","year":"1961","unstructured":"Florini, J. R., Buyske, D. A.: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J. Biol. Chem. 236, 237\u2013251 (1961).","journal-title":"J. Biol. Chem."},{"key":"5_CR11","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/0006-2952(69)90153-1","volume":"18","author":"EA Peets","year":"1969","unstructured":"Peets, E. A., Staub, M., Symchowicz, S.: Plasma binding of betamethasone 3H, dexamethasone 3H and Cortisol-14C \u2014 a comparative study. Biochem. Pharmacol 18, 1655\u20131663 (1969).","journal-title":"Biochem. Pharmacol"},{"key":"5_CR12","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1126\/science.135.3508.1062","volume":"135","author":"WR Slaunwhite Jr.","year":"1962","unstructured":"Slaunwhite, W. R., Jr., Lockie, G. N., Back, N., Sandberg, A. A.: Inactivity in vivo of trans-cortin-bound Cortisol. Science 135, 1062\u20131063 (1962).","journal-title":"Science"},{"key":"5_CR13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1172\/JCI104695","volume":"42","author":"AA Sandberg","year":"1963","unstructured":"Sandberg, A. A., Slaunwhite, W. R., Jr.: Transcortin: a corticosteroid-binding protein of plasma. V. In vitro inhibition of Cortisol metabolism. J. Clin. Invest. 42, 51\u201354 (1963).","journal-title":"J. Clin. Invest."},{"key":"5_CR14","volume-title":"Advances in Steroid Biochemistry and Pharmacology","author":"K Fotherby","year":"1972","unstructured":"Fotherby, K., James, F.: Metabolism of synthetic steroids. In: Advances in Steroid Biochemistry and Pharmacology. Briggs, M. H., Christie, G. A. (eds.) New York: Academic Press 1972."},{"key":"5_CR15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0021-9258(18)64906-3","volume":"225","author":"GM Tomkins","year":"1957","unstructured":"Tomkins, G. M., Michael, P. J.: The enzymic reduction of \u03944-3-ketosteroids. J. Biol. Chem. 225, 13\u201324 (1957).","journal-title":"J. Biol. Chem."},{"key":"5_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1210\/endo-61-1-128","volume":"61","author":"EM Glenn","year":"1957","unstructured":"Glenn, E. M., Stafford, R. O., Lyscer, S. C., Bowman, B. J.: Relation between biological activity of hydrocortisone analogs and their rates of inactivation by rat liver enzyme systems. Endocrinology 61, 128\u2013142 (1957).","journal-title":"Endocrinology"},{"key":"5_CR17","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0021-9258(18)64239-5","volume":"236","author":"JR Florini","year":"1961","unstructured":"Florini, J. R., Smith, L. L., Buyske, D. A.: Metabolic fate of a synthetic corticosteroid (triamcinolone) in the dog. J. Biol. Chem. 236, 1038\u20131042 (1961).","journal-title":"J. Biol. Chem."},{"key":"5_CR18","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1210\/jcem-37-5-811","volume":"37","author":"HL Bradlow","year":"1973","unstructured":"Bradlow, H. L., Zumoff, B., Monder, C., Lee, H. J., Hellman, L.: Isolation and identification of four new carboxyclic acid metabolites of Cortisol in man. J. Clin. Endocrinol. Metab. 37, 811\u2013818 (1973).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"5_CR19","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1021\/bi00609a005","volume":"17","author":"ME Wolff","year":"1978","unstructured":"Wolff, M. E., Baxter, J., Kollman, P. A., Lee, D. L., Kuntz, I. D., Bloom, E., Matulich, D., Morris, J.: Nature of steroid-glucocorticoid receptor interactions: thermodynamic analysis of the binding reaction. Biochem. 17, 3201\u20133208 (1978).","journal-title":"Biochem"},{"key":"5_CR20","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1016\/S0021-9258(20)79907-2","volume":"249","author":"HE Smith","year":"1974","unstructured":"Smith, H. E., Smith, R. G., Toft, D. O., Neergaard, J. R., Burrows, E. P., O\u2019Malley, B. W.: Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus. J. Biol. Chem. 249, 5924\u20135932 (1974).","journal-title":"J. Biol. Chem."},{"key":"5_CR21","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/254304a0","volume":"254","author":"C Chothia","year":"1975","unstructured":"Chothia, C.: Hydrophobic binding and accessible surface area in proteins. Nature 248, 338\u2013339 (1974); Ibid: Structural invariants in protein folding. Nature 254, 304\u2013308 (1975).","journal-title":"Nature"},{"key":"5_CR22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0022-2836(76)80148-9","volume":"100","author":"J Janin","year":"1976","unstructured":"Janin, J., Chothia, C.: Stability and specificity of protein-protein interactions: The case of the trypsin-trypsin inhibitor complexes. J. Mol. Biol. 100, 197\u2013211 (1976).","journal-title":"J. Mol. Biol."},{"key":"5_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0083-6729(08)60320-9","volume":"16","author":"J Fried","year":"1958","unstructured":"Fried, J., Borman, A.: Synthetic derivatives of cortical hormones. Vitamins and Hormones 16, 303\u2013374 (1958).","journal-title":"Vitamins and Hormones"},{"key":"5_CR24","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1021\/ja00790a021","volume":"95","author":"CM Weeks","year":"1973","unstructured":"Weeks, C. M., Duax, W. L., Wolff, M. E.: A comparison of the molecular structures of six corticosteroids. J. Am. Chem. Soc. 95, 2865\u20132868 (1973).","journal-title":"J. Am. Chem. Soc."},{"key":"5_CR25","volume-title":"Applied General Statistics","author":"FE Croxton","year":"1955","unstructured":"Croxton, F. E., Cowdon, D. J.: Applied General Statistics. Inglewood Cliffs, New Jersey: Prentice-Hall 1955."},{"key":"5_CR26","first-page":"1083","volume":"57","author":"JA Rupley","year":"1967","unstructured":"Rupley, J. A., Butler, L., Gerring, M., Hartdegen, F. J., Pecoraro, R.: Studies on the Enzymatic Activity of Lysozyme III. The Binding of Saccharides. Proc. Natl. Acad. Sci. U.S.A. 57, 1083 (1967).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Monographs on Endocrinology","Glucocorticoid Hormone Action"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-642-81265-1_5.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T22:09:00Z","timestamp":1741990140000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-642-81265-1_5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979]]},"ISBN":["9783540089735","9783642812651"],"references-count":26,"URL":"https:\/\/doi.org\/10.1007\/978-3-642-81265-1_5","relation":{},"ISSN":["0077-1015"],"issn-type":[{"value":"0077-1015","type":"print"}],"subject":[],"published":{"date-parts":[[1979]]}}}