{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:10:33Z","timestamp":1789985433033,"version":"4.0.1"},"publisher-location":"Berlin, Heidelberg","reference-count":10,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9781573314916","type":"print"},{"value":"9783662410882","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004]]},"DOI":"10.1007\/978-3-662-41088-2_4","type":"book-chapter","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T01:11:26Z","timestamp":1387501886000},"page":"36-44","source":"Crossref","is-referenced-by-count":8,"title":["Mitochondrial ALDH2 Deficiency as an Oxidative Stress"],"prefix":"10.1007","author":[{"given":"Shigeo","family":"Ohta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuroh","family":"Ohsawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouzin","family":"Kamino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujiko","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shimokata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1006\/bbrc.2000.2923","volume":"273","author":"K Kamno","year":"2000","unstructured":"Kamno, K., K. Nagasaka, M. Imagawa, et al. 2000. Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer\u2019s disease in the Japanese population. Biochem. Biophys. Res. Commun. 273: 192\u2013196.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"S46","DOI":"10.2188\/jea.10.1sup_46","volume":"10","author":"H Shimokata","year":"2000","unstructured":"Shimokata, H., Y. Yamada, M. Nakagawa, et al. 2000. Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J. Epidemiol. 10: S46\u201355.","journal-title":"J. Epidemiol."},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s10038-003-0046-y","volume":"48","author":"L Ohsawa","year":"2003","unstructured":"Ohsawa, L, K. Kamno, K. Nagasaka, et al. 2003. Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling population. J. Hum. Genet. 48: 404\u2013409.","journal-title":"J. Hum. Genet."},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1046\/j.1471-4159.2003.01619.x","volume":"84","author":"L Ohsawa","year":"2003","unstructured":"Ohsawa, L, K. Nishimaki, C. Yasuda, et al. 2003. Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J. Neurochem. 84: 1110\u20131117.","journal-title":"J. Neurochem."},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/BF00400662","volume":"39","author":"Y Suzuki","year":"1996","unstructured":"Suzuki, Y, T. Muramatsu, M. Taniyama, et al. 1996. Association of aldehyde dehydrogenase with inheritance of NIDDM. Diabetologia 39: 1115\u20131118.","journal-title":"Diabetologia"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/carcin\/19.8.1383","volume":"19","author":"A Yokoyama","year":"1998","unstructured":"Yokoyama, A., T. Muramatsu, T. Ohmori, et al. 1998. Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 19: 1383\u20131387.","journal-title":"Carcinogenesis"},{"key":"4_CR7","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1291\/hypres.24.365","volume":"24","author":"S Takagi","year":"2001","unstructured":"Takagi, S., S. Baba, N. Iwai, et al. 2001. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. Hypertens. Res. 24: 365\u2013370.","journal-title":"Hypertens. Res."},{"key":"4_CR8","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1291\/hypres.25.857","volume":"25","author":"K Amamoto","year":"2002","unstructured":"Amamoto, K., T. Okamura, S. Tamaki, et al. 2002. Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. Hypertens. Res. 25: 857\u2013864.","journal-title":"Hypertens. Res."},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1291\/hypres.25.677","volume":"25","author":"S Takagi","year":"2002","unstructured":"Takagi, S., N. Iwai, R. Yamauchi, et al. 2002. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens. Res. 25: 677\u2013681.","journal-title":"Hypertens. Res."},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1046\/j.1471-4159.2000.0741426.x","volume":"74","author":"WA Pedersen","year":"2000","unstructured":"Pedersen, W.A., S.L. Chan & M.P. Mattson. 2000. A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 74: 1426\u20131433.","journal-title":"J. Neurochem."}],"container-title":["Mitochondrial Pathogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-662-41088-2_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T14:02:06Z","timestamp":1558792926000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-662-41088-2_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"ISBN":["9781573314916","9783662410882"],"references-count":10,"URL":"https:\/\/doi.org\/10.1007\/978-3-662-41088-2_4","relation":{},"subject":[],"published":{"date-parts":[[2004]]}}}