{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:35:14Z","timestamp":1790717714285,"version":"4.1.0"},"publisher-location":"Berlin, Heidelberg","reference-count":83,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783662434918","type":"print"},{"value":"9783662434925","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014]]},"DOI":"10.1007\/978-3-662-43492-5_1","type":"book-chapter","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T04:37:14Z","timestamp":1404794234000},"page":"1-18","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["IL-10 in Humans: Lessons from the Gut, IL-10\/IL-10 Receptor Deficiencies, and IL-10 Polymorphisms"],"prefix":"10.1007","author":[{"given":"Karin R.","family":"Engelhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Grimbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"1_CR1","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1056\/NEJMra0804647","volume":"361","author":"C Abraham","year":"2009","unstructured":"Abraham C, Cho JH (2009) Inflammatory bowel disease. N Engl J Med 361:2066\u20132078. doi:10.1056\/NEJMra0804647","journal-title":"N Engl J Med"},{"key":"1_CR2","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1126\/science.1104816","volume":"307","author":"F B\u00e4ckhed","year":"2005","unstructured":"B\u00e4ckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 307:1915\u20131920","journal-title":"Science"},{"key":"1_CR3","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.immuni.2009.08.011","volume":"31","author":"MJ Barnes","year":"2009","unstructured":"Barnes MJ, Powrie F (2009) Regulatory T cells reinforce intestinal homeostasis. Immunity 31:401\u2013411. doi:10.1016\/j.immuni.2009.08.011","journal-title":"Immunity"},{"key":"1_CR4","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/ng.175","volume":"40","author":"JC Barrett","year":"2008","unstructured":"Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD et al (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn\u2019s disease. Nat Genet 40:955\u2013962. doi:10.1038\/ng.175","journal-title":"Nat Genet"},{"key":"1_CR5","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","volume":"369","author":"DC Baumgart","year":"2007","unstructured":"Baumgart DC, Carding SR (2007) Inflammatory bowel disease: cause and immunobiology. Lancet 369:1627\u20131640","journal-title":"Lancet"},{"key":"1_CR6","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1038\/ajg.2011.112","volume":"106","author":"B Begue","year":"2011","unstructured":"Begue B, Verdier J, Rieux-Laucat F, Goulet O, Morali A, Canioni D et al (2011) Defective IL-10 signaling defining a subgroup of patients with inflammatory bowel disease. Am J Gastroenterol 106:1544\u20131555. doi:10.1038\/ajg.2011.112","journal-title":"Am J Gastroenterol"},{"key":"1_CR7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.cgh.2006.03.028","volume":"4","author":"H Braat","year":"2006","unstructured":"Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP et al (2006) A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn\u2019s disease. Clin Gastroenterol Hepatol 4:754\u2013759","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1_CR8","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","volume":"34","author":"A Chaudhry","year":"2011","unstructured":"Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM et al (2011) Interleukin-10 signaling in regulatory T cells is required for suppression of th17 cell-mediated inflammation. Immunity 34:566\u2013578. doi:10.1016\/j.immuni.2011.03.018","journal-title":"Immunity"},{"key":"1_CR9","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.clim.2009.03.514","volume":"132","author":"LE Cheng","year":"2009","unstructured":"Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB et al (2009) Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol 132:124\u2013131. doi:10.1016\/j.clim.2009.03.514","journal-title":"Clin Immunol"},{"key":"1_CR10","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nri2340","volume":"8","author":"JH Cho","year":"2008","unstructured":"Cho JH (2008) The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 8:458\u2013466. doi:10.1038\/nri2340","journal-title":"Nat Rev Immunol"},{"key":"1_CR11","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.jaci.2008.02.026","volume":"121","author":"S Commins","year":"2008","unstructured":"Commins S, Steinke JW, Borish L (2008) The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. J Allergy Clin Immunol 121:1108\u20131111. doi:10.1016\/j.jaci.2008.02.026","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR12","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1089\/107999099313695","volume":"19","author":"RP Donnelly","year":"1999","unstructured":"Donnelly RP, Dickensheets H, Finbloom DS (1999) The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J Interferon Cytokine Res 19:563\u2013573","journal-title":"J Interferon Cytokine Res"},{"key":"1_CR13","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1189\/jlb.0204117","volume":"76","author":"RP Donnelly","year":"2004","unstructured":"Donnelly RP, Sheikh F, Kotenko SV, Dickensheets H (2004) The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain. J Leukoc Biol 76:314\u2013321","journal-title":"J Leukoc Biol"},{"key":"1_CR14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.0105-2896.2005.00291.x","volume":"206","author":"CO Elson","year":"2005","unstructured":"Elson CO, Cong Y, McCracken VJ, Dimmitt RA, Lorenz RG, Weaver CT (2005) Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol Rev 206:60\u201376","journal-title":"Immunol Rev"},{"key":"1_CR15","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1053\/j.gastro.2007.03.104","volume":"132","author":"CO Elson","year":"2007","unstructured":"Elson CO, Cong Y, Weaver CT, Schoeb TR, McClanahan TK, Fick RB, Kastelein RA (2007) Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132:2359\u20132370","journal-title":"Gastroenterology"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00535-010-0219-3","volume":"45","author":"MA Engel","year":"2010","unstructured":"Engel MA, Neurath MF (2010) New pathophysiological insights and modern treatment of IBD. J Gastroenterol 45:571\u2013583. doi:10.1007\/s00535-010-0219-3","journal-title":"J Gastroenterol"},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.jaci.2012.09.025","volume":"131","author":"KR Engelhardt","year":"2013","unstructured":"Engelhardt KR, Shah N, Faizura-Yeop I, Kocacik Uygun DF, Frede N, Muise AM et al (2013) Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation. J Allergy Clin Immunol 131:825\u2013830. doi:10.1016\/j.jaci.2012.09.025","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR18","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3748\/wjg.v17.i5.557","volume":"17","author":"F Fava","year":"2011","unstructured":"Fava F, Danese S (2011) Intestinal microbiota in inflammatory bowel disease: friend or foe? World J Gastroenterol 17:557\u2013566. doi:10.3748\/wjg.v17.i5.557","journal-title":"World J Gastroenterol"},{"key":"1_CR19","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","volume":"147","author":"DF Fiorentino","year":"1991","unstructured":"Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O\u2019Garra A (1991a) IL-10 inhibits cytokine production by activated macrophages. J Immunol 147:3815\u20133822","journal-title":"J Immunol"},{"key":"1_CR20","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.4049\/jimmunol.146.10.3444","volume":"146","author":"DF Fiorentino","year":"1991","unstructured":"Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O\u2019Garra A (1991b) IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 146:3444\u20133451","journal-title":"J Immunol"},{"key":"1_CR21","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ng.148","volume":"40","author":"A Franke","year":"2008","unstructured":"Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T et al (2008a) Replication of signals from recent studies of Crohn\u2019s disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet 40:713\u2013715. doi:10.1038\/ng.(a)","journal-title":"Nat Genet"},{"key":"1_CR22","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/ng.221","volume":"40","author":"A Franke","year":"2008","unstructured":"Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G et al (2008b) Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 40:1319\u20131323. doi:10.1038\/ng.221.(b)","journal-title":"Nat Genet"},{"key":"1_CR23","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ng.717","volume":"42","author":"A Franke","year":"2010","unstructured":"Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T et al (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn\u2019s disease susceptibility loci. Nat Genet 42:1118\u20131125. doi:10.1038\/ng.717","journal-title":"Nat Genet"},{"key":"1_CR24","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1056\/NEJMoa0907206","volume":"361","author":"EO Glocker","year":"2009","unstructured":"Glocker EO, Kotlarz D, Boztug K, Gertz EM, Sch\u00e4ffer AA, Noyan F et al (2009) Inflammatory bowel disease and mutations affecting the Interleukin-10 Receptor. N Engl J Med 361:2033\u20132045. doi:10.1056\/NEJMoa0907206","journal-title":"N Engl J Med"},{"key":"1_CR25","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/S0140-6736(10)61008-2","volume":"376","author":"EO Glocker","year":"2010","unstructured":"Glocker EO, Frede N, Perro M, Sebire N, Elawad M, Shah N et al (2010) Infant colitis\u2014it\u2019s in the genes. Lancet 376:1272. doi:10.1016\/S0140-6736(10)61008-2","journal-title":"Lancet"},{"key":"1_CR26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/07853890701197615","volume":"39","author":"P Goyette","year":"2007","unstructured":"Goyette P, Labb\u00e9 C, Trinh TT, Xavier RJ, Rioux JD (2007) Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine. Ann Med 39:177\u2013199","journal-title":"Ann Med"},{"key":"1_CR27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ng1954","volume":"39","author":"J Hampe","year":"2007","unstructured":"Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K et al (2007) A genome-wide association scan of non-synonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39:207\u2013211","journal-title":"Nat Genet"},{"key":"1_CR28","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1056\/NEJMoa073687","volume":"357","author":"SM Holland","year":"2007","unstructured":"Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N et al (2007) STAT3 mutations in the hyper-IgE syndrome. N Engl J Med 357:1608\u20131619","journal-title":"N Engl J Med"},{"key":"1_CR29","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.immuni.2011.01.020","volume":"34","author":"S Huber","year":"2011","unstructured":"Huber S, Gagliani N, Esplugues E, O\u2019Connor W Jr, Huber FJ, Chaudhry A et al (2011) Th17 cells express interleukin-10 receptor and are controlled by Foxp3(\u2212) and Foxp3(+) regulatory CD4(+) T cells in an interleukin-10-dependent manner. Immunity 34:554\u2013565. doi:10.1016\/j.immuni.2011.01.020","journal-title":"Immunity"},{"key":"1_CR30","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot JP, Chamaillard M, Zouali H, Lesage S, C\u00e9zard JP, Belaiche J et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease. Nature 411:599\u2013603","journal-title":"Nature"},{"key":"1_CR31","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/ng.489","volume":"41","author":"M Imielinski","year":"2009","unstructured":"Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M et al (2009) Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet 41:1335\u20131340. doi:10.1038\/ng.489","journal-title":"Nat Genet"},{"key":"1_CR32","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1084\/jem.20061660","volume":"204","author":"T Ito","year":"2007","unstructured":"Ito T, Yang M, Wang YH, Lande R, Gregorio J, Perng OA et al (2007) Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med 204:105\u2013115","journal-title":"J Exp Med"},{"key":"1_CR33","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.0105-2896.2006.00423.x","volume":"212","author":"A Izcue","year":"2006","unstructured":"Izcue A, Coombes JL, Powrie F (2006) Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev 212:256\u2013271","journal-title":"Immunol Rev"},{"key":"1_CR34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY et al (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491:119\u2013124. doi:10.1038\/nature11582","journal-title":"Nature"},{"key":"1_CR35","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","volume":"134","author":"A Kaser","year":"2008","unstructured":"Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H et al (2008) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134:743\u2013756. doi:10.1016\/j.cell.2008.07.021","journal-title":"Cell"},{"key":"1_CR36","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1016\/j.yexcr.2011.07.008","volume":"317","author":"A Kaser","year":"2011","unstructured":"Kaser A, Flak MB, Tomczak MF, Blumberg RS (2011) The\u00a0unfolded protein response and its role in intestinal homeostasis and inflammation. Exp Cell Res 317:2772\u20132779. doi:10.1016\/j.yexcr.2011.07.008","journal-title":"Exp Cell Res"},{"key":"1_CR37","doi-asserted-by":"publisher","first-page":"5894","DOI":"10.1093\/emboj\/16.19.5894","volume":"16","author":"SV Kotenko","year":"1997","unstructured":"Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997) Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J 16:5894\u20135903","journal-title":"EMBO J"},{"key":"1_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/ni875","volume":"4","author":"SV Kotenko","year":"2003","unstructured":"Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK et al (2003) IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 4:69\u201377","journal-title":"Nat Immunol"},{"key":"1_CR39","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1053\/j.gastro.2012.04.045","volume":"143","author":"D Kotlarz","year":"2012","unstructured":"Kotlarz D, Beier R, Murugan D, Diestelhorst J, Jensen O, Boztug K et al (2012) Loss of interleukin-10 signaling and infantile inflammatory bowel disease\u2014implications for diagnosis and therapy. Gastroenterology 143:347\u2013355. doi:10.1053\/j.gastro.2012.04.045","journal-title":"Gastroenterology"},{"key":"1_CR40","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","volume":"75","author":"R K\u00fchn","year":"1993","unstructured":"K\u00fchn R, L\u00f6hler J, Rennick D, Rajewsky K, M\u00fcller W (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263\u2013274","journal-title":"Cell"},{"key":"1_CR41","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1002\/ibd.21493","volume":"17","author":"A Levine","year":"2011","unstructured":"Levine A, Griffiths A, Markowitz J, Wilson DC, Turner D, Russell RK et al (2011) Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis 17:1314\u20131321. doi:10.1002\/ibd.21493","journal-title":"Inflamm Bowel Dis"},{"key":"1_CR42","doi-asserted-by":"crossref","unstructured":"Liu Y, Wei SH, Ho AS, de Waal R, Malefyt, Moore KW (1994) Expression cloning and characterization of a human IL-10 receptor. J Immunol 152:1821\u20131829","DOI":"10.4049\/jimmunol.152.4.1821"},{"key":"1_CR43","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.4049\/jimmunol.173.5.3119","volume":"173","author":"S Makita","year":"2004","unstructured":"Makita S, Kanai T, Oshima S, Uraushihara K, Totsuka T, Sawada T et al (2004) CD4\u00a0+\u00a0CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 173:3119\u20133130","journal-title":"J Immunol"},{"key":"1_CR44","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/gene.2012.8","volume":"13","author":"H Mao","year":"2012","unstructured":"Mao H, Yang W, Lee PP, Ho MH, Yang J, Zeng S et al (2012) Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn\u2019s disease. Genes Immun 13:437\u2013442. doi:10.1038\/gene.2012.8","journal-title":"Genes Immun"},{"key":"1_CR45","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/path.2291","volume":"214","author":"DJ Marks","year":"2008","unstructured":"Marks DJ, Segal AW (2008) Innate immunity in inflammatory bowel disease: a disease hypothesis. J Pathol 214:260\u2013266","journal-title":"J Pathol"},{"key":"1_CR46","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/ajg.2008.72","volume":"104","author":"DJ Marks","year":"2009","unstructured":"Marks DJ, Miyagi K, Rahman FZ, Novelli M, Bloom SL, Segal AW (2009) Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn\u2019s disease. Am J Gastroenterol 104:117\u2013124. doi:10.1038\/ajg.2008.72","journal-title":"Am J Gastroenterol"},{"key":"1_CR47","doi-asserted-by":"publisher","unstructured":"Maxwell JR, Viney JL (2009) Overview of mouse models of inflammatory bowel disease and their use in drug discovery. Curr Protoc Pharmacol Chapter 5: Unit5.57. doi: 10.1002\/0471141755.ph0557s47","DOI":"10.1002\/0471141755.ph0557s47"},{"key":"1_CR48","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/ni1504","volume":"8","author":"CL Maynard","year":"2007","unstructured":"Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, Rudensky AY, Weaver CT (2007) Regulatory T cells expressing interleukin 10 develop from Foxp3\u00a0+\u00a0and Foxp3-precursor cells in the absence of interleukin 10. Nat Immunol 8:931\u2013941","journal-title":"Nat Immunol"},{"key":"1_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00535-007-2111-3","volume":"43","author":"A Mizoguchi","year":"2008","unstructured":"Mizoguchi A, Mizoguchi E (2008) Inflammatory bowel disease, past, present, and future: lessons from animal models. J Gastroenterol 43:1\u201317. doi:10.1007\/s00535-007-2111-3","journal-title":"J Gastroenterol"},{"key":"1_CR50","doi-asserted-by":"crossref","unstructured":"Moore KW, O\u2019Garra A, de Waal Malefyt R, Vieira P, Mosmann TR (1993) Interleukin-10. Annu Rev Immunol 11:165\u201390","DOI":"10.1146\/annurev.iy.11.040193.001121"},{"key":"1_CR51","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal Malefyt R, Coffman RL, O\u2019Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683\u2013765","journal-title":"Annu Rev Immunol"},{"issue":"Suppl 1","key":"1_CR52","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1007\/s10875-008-9176-5","volume":"28","author":"D Moraes-Vasconcelos","year":"2008","unstructured":"Moraes-Vasconcelos D, Costa-Carvalho BT, Torgerson TR, Ochs HD (2008) Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED. J Clin Immunol 28(Suppl 1):S11\u2013S19. doi:10.1007\/s10875-008-9176-5","journal-title":"J Clin Immunol"},{"key":"1_CR53","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/ibd.22974","volume":"19","author":"CJ Moran","year":"2013","unstructured":"Moran CJ, Walters TD, Guo CH, Kugathasan S, Klein C, Turner D et al (2013) IL10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis 19:115\u2013123","journal-title":"Inflamm Bowel Dis"},{"key":"1_CR54","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/ni.1791","volume":"10","author":"M Murai","year":"2009","unstructured":"Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H et al (2009) Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 10:1178\u20131184. doi:10.1038\/ni.1791","journal-title":"Nat Immunol"},{"key":"1_CR55","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/02648725.2006.10648073","volume":"22","author":"S Neirynck","year":"2006","unstructured":"Neirynck S, Steidler L (2006) Delivery of therapeutic proteins through Lactococcus lactis. Biotechnol Genet Eng Rev 22:253\u2013266","journal-title":"Biotechnol Genet Eng Rev"},{"key":"1_CR56","doi-asserted-by":"publisher","first-page":"652","DOI":"10.4161\/cc.9.4.10615","volume":"9","author":"C Neufert","year":"2010","unstructured":"Neufert C, Pickert G, Zheng Y, Wittkopf N, Warntjen M, Nikolaev A et al (2010) Activation of epithelial STAT3 regulates intestinal homeostasis. Cell Cycle 9:652\u2013655","journal-title":"Cell Cycle"},{"key":"1_CR57","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.trsl.2011.09.001","volume":"160","author":"MG Neuman","year":"2012","unstructured":"Neuman MG, Nanau RM (2012) Inflammatory bowel disease: role of diet, microbiota, life style. Transl Res 160:29\u201344. doi:10.1016\/j.trsl.2011.09.001","journal-title":"Transl Res"},{"key":"1_CR58","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/ibd.21747","volume":"18","author":"SC Ng","year":"2012","unstructured":"Ng SC, Woodrow S, Patel N, Subhani J, Harbord M (2012) Role of genetic and environmental factors in British twins with inflammatory bowel disease. Inflamm Bowel Dis 18:725\u2013736. doi:10.1002\/ibd.21747","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"1_CR59","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/ni0909-929","volume":"10","author":"A O\u2019Garra","year":"2009","unstructured":"O\u2019Garra A, Murphy KM (2009) From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development. Nat Immunol 10(9):929\u2013932. doi:10.1038\/ni0909-929","journal-title":"Nat Immunol"},{"key":"1_CR60","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1182\/blood-2010-07-298372","volume":"117","author":"J Pachlopnik Schmid","year":"2011","unstructured":"Pachlopnik Schmid J, Canioni D, Moshous D, Touzot F, Mahlaoui N, Hauck F et al (2011) Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1\/SAP deficiency) vs type 2 (XLP-2\/XIAP deficiency). Blood 117:1522\u20131529. doi:10.1182\/blood-2010-07-298372","journal-title":"Blood"},{"key":"1_CR61","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/ng2061","volume":"39","author":"M Parkes","year":"2007","unstructured":"Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA et al (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn\u2019s disease susceptibility. Nat Genet 39:830\u2013832","journal-title":"Nat Genet"},{"key":"1_CR62","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1146\/annurev.immunol.22.012703.104622","volume":"22","author":"S Pestka","year":"2004","unstructured":"Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB (2004) Interleukin-10 and related cytokines and receptors. Annu Rev Immunol 22:929\u2013979","journal-title":"Annu Rev Immunol"},{"key":"1_CR63","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1056\/NEJMra020831","volume":"347","author":"DK Podolsky","year":"2002","unstructured":"Podolsky DK (2002) Inflammatory bowel disease. N Engl J Med 347:417\u2013429","journal-title":"N Engl J Med"},{"key":"1_CR64","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/ng2032","volume":"39","author":"JD Rioux","year":"2007","unstructured":"Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A et al (2007) Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39:596\u2013604","journal-title":"Nat Genet"},{"key":"1_CR65","doi-asserted-by":"publisher","first-page":"3776","DOI":"10.3748\/wjg.15.3776","volume":"15","author":"R Sanchez","year":"2009","unstructured":"Sanchez R, Levy E, Costea F, Sinnett D (2009) IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn\u2019s disease location. World J Gastroenterol 15:3776\u20133782","journal-title":"World J Gastroenterol"},{"key":"1_CR66","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1136\/gut.35.5.696","volume":"35","author":"J Satsangi","year":"1994","unstructured":"Satsangi J, Jewell DP, Rosenberg WM, Bell JI (1994) Genetics of inflammatory bowel disease. Gut 35:696\u2013700","journal-title":"Gut"},{"key":"1_CR67","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1136\/adc.88.11.995","volume":"88","author":"A Sawczenko","year":"2003","unstructured":"Sawczenko A, Sandhu BK (2003) Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child 88:995\u20131000","journal-title":"Arch Dis Child"},{"issue":"1 Suppl","key":"1_CR68","doi-asserted-by":"publisher","first-page":"S123","DOI":"10.1016\/j.bbmt.2010.09.008","volume":"17","author":"BH Segal","year":"2011","unstructured":"Segal BH, Veys P, Malech H, Cowan MJ (2011) Chronic granulomatous disease: lessons from a rare disorder. Biol Blood Marrow Transplant 17(1 Suppl):S123\u2013S131. doi:10.1016\/j.bbmt.2010.09.008","journal-title":"Biol Blood Marrow Transplant"},{"key":"1_CR69","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1084\/jem.187.4.571","volume":"187","author":"SD Spencer","year":"1998","unstructured":"Spencer SD, Di Marco F, Hooley J, Pitts-Meek S, Bauer M, Ryan AM et al (1998) The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med 187:571\u2013578","journal-title":"J Exp Med"},{"key":"1_CR70","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/ng1345","volume":"36","author":"M Stoll","year":"2004","unstructured":"Stoll M, Corneliussen B, Costello CM, Waetzig GH, Mellgard B, Koch WA et al (2004) Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 36:476\u2013480","journal-title":"Nat Genet"},{"key":"1_CR71","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrm1203","volume":"4","author":"D Taupin","year":"2003","unstructured":"Taupin D, Podolsky DK (2003) Trefoil factors: initiators of mucosal healing. Nat Rev Mol Cell Biol 4:721\u2013732","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1_CR72","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nri2724","volume":"10","author":"AJ Thrasher","year":"2010","unstructured":"Thrasher AJ, Burns SO (2010) WASP: a key immunological multitasker. Nat Rev Immunol 10:182\u2013192. doi:10.1038\/nri2724","journal-title":"Nat Rev Immunol"},{"key":"1_CR73","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.jaci.2007.08.044","volume":"120","author":"TR Torgerson","year":"2007","unstructured":"Torgerson TR, Ochs HD (2007) Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol 120:744\u2013750","journal-title":"J Allergy Clin Immunol"},{"key":"1_CR74","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.2353\/ajpath.2006.060681","volume":"169","author":"JR Turner","year":"2006","unstructured":"Turner JR (2006) Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol 169:1901\u20131909","journal-title":"Am J Pathol"},{"key":"1_CR75","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00281-005-0206-6","volume":"27","author":"HH Uhlig","year":"2005","unstructured":"Uhlig HH, Powrie F (2005) The role of mucosal T lymphocytes in regulating intestinal inflammation. Springer Semin Immunopathol 27:167\u2013180","journal-title":"Springer Semin Immunopathol"},{"key":"1_CR76","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev-genom-082908-150013","volume":"10","author":"J Van Limbergen","year":"2009","unstructured":"Van Limbergen J, Wilson DC, Satsangi J (2009) The genetics of Crohn\u2019s disease. Annu Rev Genomics Hum Genet 10:89\u2013116. doi:10.1146\/annurev-genom-082908-150013","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"1_CR77","doi-asserted-by":"publisher","first-page":"27954","DOI":"10.1074\/jbc.271.44.27954","volume":"271","author":"RM Weber-Nordt","year":"1996","unstructured":"Weber-Nordt RM, Riley JK, Greenlund AC, Moore KW, Darnell JE, Schreiber RD (1996) Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain. J Biol Chem 271:27954\u201327961","journal-title":"J Biol Chem"},{"key":"1_CR78","doi-asserted-by":"publisher","first-page":"567","DOI":"10.4049\/jimmunol.172.1.567","volume":"172","author":"L Williams","year":"2004","unstructured":"Williams L, Bradley L, Smith A, Foxwell B (2004) Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J Immunol 172:567\u2013576","journal-title":"J Immunol"},{"key":"1_CR79","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","volume":"21","author":"K Wolk","year":"2004","unstructured":"Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R (2004) IL-22 increases the innate immunity of tissues. Immunity 21:241\u2013254","journal-title":"Immunity"},{"key":"1_CR80","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1002\/eji.200535503","volume":"36","author":"K Wolk","year":"2006","unstructured":"Wolk K, Witte E, Wallace E, D\u00f6cke WD, Kunz S, Asadullah K et al (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 36:1309\u20131323","journal-title":"Eur J Immunol"},{"key":"1_CR81","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"RJ Xavier","year":"2007","unstructured":"Xavier RJ, Podolsky DK (2007) Unraveling the pathogenesis of inflammatory bowel disease. Nature 448:427\u2013434","journal-title":"Nature"},{"key":"1_CR82","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/ar4069","volume":"14","author":"PF Yong","year":"2012","unstructured":"Yong PF, Freeman AF, Engelhardt KR, Holland S, Puck JM, Grimbacher B (2012) An update on the hyper-IgE syndromes. Arthritis Res Ther 14:228","journal-title":"Arthritis Res Ther"},{"key":"1_CR83","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.it.2011.02.002","volume":"32","author":"MH Zaki","year":"2011","unstructured":"Zaki MH, Lamkanfi M, Kanneganti TD (2011) The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol 32:171\u2013179. doi:10.1016\/j.it.2011.02.002","journal-title":"Trends Immunol"}],"container-title":["Current Topics in Microbiology and Immunology","Interleukin-10 in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-662-43492-5_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T20:24:27Z","timestamp":1674159867000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-3-662-43492-5_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"ISBN":["9783662434918","9783662434925"],"references-count":83,"URL":"https:\/\/doi.org\/10.1007\/978-3-662-43492-5_1","relation":{},"ISSN":["0070-217X","2196-9965"],"issn-type":[{"value":"0070-217X","type":"print"},{"value":"2196-9965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"9 July 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}