{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T06:53:02Z","timestamp":1742971982680,"version":"3.40.3"},"publisher-location":"Berlin, Heidelberg","reference-count":9,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783662565360"},{"type":"electronic","value":"9783662565377"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-3-662-56537-7_86","type":"book-chapter","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T13:08:50Z","timestamp":1519132130000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Variational Networks for Joint Image Reconstruction and Classification of Tumor Immune Cell Interactions in Melanoma Tissue Sections"],"prefix":"10.1007","author":[{"given":"Alexander","family":"Effland","sequence":"first","affiliation":[]},{"given":"Michael","family":"H\u00f6lzel","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Klatzer","sequence":"additional","affiliation":[]},{"given":"Erich","family":"Kobler","sequence":"additional","affiliation":[]},{"given":"Jennifer","family":"Landsberg","sequence":"additional","affiliation":[]},{"given":"Leonie","family":"Neuh\u00e4user","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Pock","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Rumpf","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"86_CR1","doi-asserted-by":"crossref","unstructured":"Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515:568\u2013571.","DOI":"10.1038\/nature13954"},{"key":"86_CR2","doi-asserted-by":"crossref","unstructured":"Jacquelot N, Roberti MP, Enot DP, et al. Predictors of responses to immune checkpoint blockade in advanced melanoma. Nat Commun. 2017;8.","DOI":"10.1080\/2162402X.2017.1299303"},{"key":"86_CR3","doi-asserted-by":"crossref","unstructured":"Sirinukunwattana K, Raza SEA, Tsang YW, et al. Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images. IEEE Trans Med Imaging. 2016;35(5):1196\u20131206.","DOI":"10.1109\/TMI.2016.2525803"},{"key":"86_CR4","doi-asserted-by":"crossref","unstructured":"Xu J, Luo X, Wang G, et al. A Deep Convolutional Neural Network for segmenting and classifying epithelial and stromal regions in histopathological images. Neurocomputing. 2016;191:214\u2013223.","DOI":"10.1016\/j.neucom.2016.01.034"},{"key":"86_CR5","doi-asserted-by":"crossref","unstructured":"Janowczyk A, Madabhushi A. Deep Learning for Digital Pathology Image Analysis: A Comprehensive Tutorial with Selected Use Cases. J Pathol Inform. 2016;7.","DOI":"10.4103\/2153-3539.186902"},{"key":"86_CR6","doi-asserted-by":"crossref","unstructured":"Chen Y, Pock T. Trainable nonlinear reaction diffusion: A flexible framework for fast and effective image restoration. IEEE Trans Pattern Anal Mach Intell. 2017;39(6):1256\u20131272.","DOI":"10.1109\/TPAMI.2016.2596743"},{"key":"86_CR7","doi-asserted-by":"crossref","unstructured":"Kobler E, Klatzer T, Hammernik K, et al. Variational Networks: Connecting Variational Methods and Deep Learning. In: Ger Pattern Recognit Conf; 2017. p. 281\u2013293.","DOI":"10.1007\/978-3-319-66709-6_23"},{"key":"86_CR8","unstructured":"Kingma DP, Ba JL. Adam: AMethod for Stochastic Optimization. In: International Conference on Learning Representations; 2015."},{"key":"86_CR9","doi-asserted-by":"crossref","unstructured":"Landsberg J, Kohlmeyer J, Renn M, et al. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature. 2012;490:412\u2013416.","DOI":"10.1038\/nature11538"}],"container-title":["Informatik aktuell","Bildverarbeitung f\u00fcr die Medizin 2018"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-662-56537-7_86","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T06:00:53Z","timestamp":1558159253000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-662-56537-7_86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783662565360","9783662565377"],"references-count":9,"URL":"https:\/\/doi.org\/10.1007\/978-3-662-56537-7_86","relation":{},"ISSN":["1431-472X"],"issn-type":[{"type":"print","value":"1431-472X"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"21 February 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}