{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T11:26:35Z","timestamp":1725708395761},"publisher-location":"Vienna","reference-count":24,"publisher":"Springer Vienna","isbn-type":[{"type":"print","value":"9783211204542"},{"type":"electronic","value":"9783709105726"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004]]},"DOI":"10.1007\/978-3-7091-0572-6_17","type":"book-chapter","created":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T18:13:18Z","timestamp":1354385598000},"page":"191-200","source":"Crossref","is-referenced-by-count":1,"title":["A novel principle of attenuation for the development of new generation live flavivirus vaccines"],"prefix":"10.1007","author":[{"given":"R. M.","family":"Kofler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. X.","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Mandl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"17_CR1","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1128\/JVI.69.9.5816-5820.1995","volume":"69","author":"SL Allison","year":"1995","unstructured":"Allison SL, Stadler K, Mandl CW, Kunz C, Heinz FX (1995) Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form. J Virol 69:5816\u20135820","journal-title":"J Virol"},{"key":"17_CR2","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1128\/JVI.75.2.934-942.2001","volume":"75","author":"J Arroyo","year":"2001","unstructured":"Arroyo J, Guirakhoo F, Fenner S, Zhang ZX, Monath TP, Chambers TJ (2001) Molecular basis for attenuation of neurovirulence of a yellow fever virus\/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE). J Virol 75:934\u2013942","journal-title":"J Virol"},{"key":"17_CR3","doi-asserted-by":"crossref","first-page":"9778","DOI":"10.1021\/bi990923a","volume":"38","author":"P Braun","year":"1999","unstructured":"Braun P, von Heijne G (1999) The aromatic residues Trp and Phe have different effects on the positioning of a transmembrane helix in the microsomal membrane. Biochem 38:9778\u20139782","journal-title":"Biochem"},{"key":"17_CR4","first-page":"1043","volume-title":"Fields virology","author":"DS Burke","year":"2001","unstructured":"Burke DS, Monath TP (2001) Flaviviruses, pp 1043\u20131125. In: Knipe DM, Howley PM et al. (eds), Fields virology, 4th edn. Lippincot Williams & Wilkins, Philadelphia, Pa","edition":"4th edn"},{"key":"17_CR5","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S1097-2765(01)00206-4","volume":"7","author":"I Ferlenghi","year":"2001","unstructured":"Ferlenghi I, Clarke M, Ruttan T, Allison SL, Schalich J, Heinz FX, Harrison SC, Rey FA, Fuller SD (2001) Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. Mol Cell 7:593\u2013602","journal-title":"Mol Cell"},{"key":"17_CR6","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1016\/0264-410X(95)00133-L","volume":"13","author":"FX Heinz","year":"1995","unstructured":"Heinz FX, Allison SL, Stiasny K, Schalich J, Holzmann H, Mandl CW, Kunz C (1995) Recombinant and virion-derived soluble and particulate immunogens for vaccination against tick-borne encephalitis. Vaccine 13:1636\u20131642","journal-title":"Vaccine"},{"key":"17_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/0092-1157(86)90032-6","volume":"14","author":"FX Heinz","year":"1986","unstructured":"Heinz FX, Tuma W, Guirakhoo F, Kunz C (1986) A model study of the use of monoclonal antibodies in capture enzyme immunoassays for antigen quantification exploiting the epitope map of tick-borne encephalitis virus. J Biol Stand 14:133\u2013141","journal-title":"J Biol Stand"},{"key":"17_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1099\/0022-1317-78-1-31","volume":"78","author":"H Holzmann","year":"1997","unstructured":"Holzmann H, Stiasny K, Ecker M, Kunz C, Heinz FX (1997) Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice. J Gen Virol 78:31\u201337","journal-title":"J Gen Virol"},{"key":"17_CR9","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1128\/JVI.76.7.3534-3543.2002","volume":"76","author":"RM Kofler","year":"2002","unstructured":"Kofler RM, Heinz FX, Mandl CW (2002) Capsid protein C of tick-borne encephalitis virus tolerates large internal deletions and is a favorable target for attenuation of virulence. J Virol 76:3534\u20133543","journal-title":"J Virol"},{"key":"17_CR10","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1128\/JVI.77.1.443-451.2003","volume":"77","author":"RM Kofler","year":"2003","unstructured":"Kofler RM, Leitner A, O\u2019Riordain G, Heinz FX, Mandl CW (2003) Spontaneous mutations restore the viability of tick-borne encephalitis virus mutants with large deletions in protein C. J Virol 77:443\u2013451","journal-title":"J Virol"},{"key":"17_CR11","first-page":"991","volume-title":"Fields Virology","author":"BD Lindenbach","year":"2001","unstructured":"Lindenbach BD, Rice CM (2001) Flaviviridae: The viruses and their replication. In:Knipe DM, Howley PM et al. (eds), Fields Virology. 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 991\u20131041","edition":"4th"},{"key":"17_CR12","doi-asserted-by":"publisher","first-page":"9601","DOI":"10.1128\/JVI.74.20.9601-9609.2000","volume":"74","author":"CW Mandl","year":"2000","unstructured":"Mandl CW, Allison SL, Holzmann H, Meixner T, Heinz FX (2000) Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site. J Virol 74:9601\u20139609","journal-title":"J Virol"},{"key":"17_CR13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1099\/0022-1317-78-5-1049","volume":"78","author":"CW Mandl","year":"1997","unstructured":"Mandl CW, Ecker M, Holzmann H, Kunz C, Heinz FX (1997) Infectious cDNA clones of tick-borne encephalitis virus European subtype prototypic strain Neudoerfl and high virulence strain Hypr. J Gen Virol 78:1049\u20131057","journal-title":"J Gen Virol"},{"key":"17_CR14","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0042-6822(88)90161-4","volume":"166","author":"CW Mandl","year":"1988","unstructured":"Mandl CW, Heinz FX, Kunz C (1988) Sequence of the structural proteins of tick-borne encephalitis virus (Western subtype) and comparative analysis with other flaviviruses. Virology 166:197\u2013205","journal-title":"Virology"},{"key":"17_CR15","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0042-6822(89)90246-8","volume":"173","author":"CW Mandl","year":"1989","unstructured":"Mandl CW, Heinz FX, Stockl E, Kunz C (1989) Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of non structural proteins with other flaviviruses. Virology 173:291\u2013301","journal-title":"Virology"},{"key":"17_CR16","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1128\/JVI.72.3.2132-2140.1998","volume":"72","author":"CW Mandl","year":"1998","unstructured":"Mandl CW, Holzmann H, Meixner T, Rauscher S, Stadler PF, Allison SL, Heinz FX (1998) Spontaneous and engineered deletions in the 3\u2032 noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus. J Virol 72:2132\u20132140","journal-title":"J Virol"},{"key":"17_CR17","doi-asserted-by":"publisher","first-page":"5627","DOI":"10.1128\/JVI.75.12.5627-5637.2001","volume":"75","author":"CW Mandl","year":"2001","unstructured":"Mandl CW, Kroschewski H, Allison SL, Kofler R, Holzmann H, Meixner T, Heinz FX (2001) Adaptation of tick-borne encephalitis virus to BHK-21 cells results in the formation of multiple heparan sulfate binding sites in the envelope protein and attenuation in vivo. J Virol 75:5627\u20135637","journal-title":"J Virol"},{"key":"17_CR18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1006\/viro.1997.8608","volume":"233","author":"L Markoff","year":"1997","unstructured":"Markoff L, Falgout B, Chang A (1997) A conserved internal hydrophobic domain mediates the stable membrane integration of the dengue virus capsid protein. Virology 233:105\u2013117","journal-title":"Virology"},{"key":"17_CR19","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/0042-6822(91)90034-9","volume":"180","author":"PW Mason","year":"1991","unstructured":"Mason PW, Pincus S, Fournier MJ, Mason TL, Shope RE, Paoletti E (1991) Japanese encephalitis virus-vaccinia recombinants produce particulate forms of the structural membrane proteins and induce high levels of protection against lethal JEV infection. Virology 180:294\u2013305","journal-title":"Virology"},{"key":"17_CR20","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1099\/0022-1317-78-11-2711","volume":"78","author":"P McMinn","year":"1997","unstructured":"McMinn PC (1997) The molecular basis of virulence of the encephalitogenic flaviviruses. J Gen Virol 78:2711\u20132722","journal-title":"J Gen Virol"},{"key":"17_CR21","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0065-3527(08)60348-6","volume":"53","author":"N Ruggli","year":"1999","unstructured":"Ruggli N, Rice CM (1999) Functional cDNA clones of the flaviviridae: strategies and applications. Adv Virus Res 53:183\u2013207","journal-title":"Adv Virus Res"},{"key":"17_CR22","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1128\/JVI.70.7.4549-4557.1996","volume":"70","author":"J Schalich","year":"1996","unstructured":"Schalich J, Allison SL, Stiasny K, Mandl CW, Kunz C, Heinz FX (1996) Recombinant subviral particles from tick-borne encephalitis virus are fusogenic and provide a model system for studying flavivirus envelope glycoprotein functions. J Virol 70:4549\u20134557","journal-title":"J Virol"},{"key":"17_CR23","unstructured":"van Regenmortel MHV, Faquet CM, Bishop DHL, Carstens EB, Estes MK, Lemon SM, Maniloff J, Mayo MA, McGeoch DJ, Pringle CR, Wickner RB (eds) (2000) Virus taxonomy: classification and nomenclature of viruses. Academic Press, London, pp 859\u2013878"},{"key":"17_CR24","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1099\/0022-1317-77-5-1035","volume":"77","author":"G Wallner","year":"1996","unstructured":"Wallner G, Mandl CW, Ecker M, Holzmann H, Stiasny K, Kunz C, Heinz FX (1996) Characterization and complete genome sequences of high-and low-virulence variants of tick-borne encephalitis virus. J Gen Virol 77:1035\u20131042","journal-title":"J Gen Virol"}],"container-title":["Emergence and Control of Zoonotic Viral Encephalitides"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-7091-0572-6_17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T05:49:18Z","timestamp":1594964958000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-7091-0572-6_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"ISBN":["9783211204542","9783709105726"],"references-count":24,"URL":"https:\/\/doi.org\/10.1007\/978-3-7091-0572-6_17","relation":{},"subject":[],"published":{"date-parts":[[2004]]}}}