{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:52:13Z","timestamp":1771001533204,"version":"3.50.1"},"publisher-location":"Vienna","reference-count":25,"publisher":"Springer Vienna","isbn-type":[{"value":"9783211403556","type":"print"},{"value":"9783709160909","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003]]},"DOI":"10.1007\/978-3-7091-6090-9_15","type":"book-chapter","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T23:49:45Z","timestamp":1343519385000},"page":"93-103","source":"Crossref","is-referenced-by-count":18,"title":["Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma"],"prefix":"10.1007","author":[{"given":"F. W.","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Floeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Asher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bucholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Berge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pradoss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bruces","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"Raino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Westphal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Warnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Rand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. N.","family":"Hingorani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. K.","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"15_CR1","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1073\/pnas.91.6.2076","volume":"91","author":"RH Bobo","year":"1994","unstructured":"Bobo RH, Laske DW, Akbasak A et al (1994) Convectionenhanced delivery of macromolecules in the brain. Proc Nat! Acad Sci USA 91: 2076\u20132080","journal-title":"Acad Sci USA"},{"key":"15_CR2","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/S0140-6736(95)90755-6","volume":"345","author":"H Brem","year":"1995","unstructured":"Brem H, Piantadosi S, Burger PC et al (1995) Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet 345: 1008\u20131012","journal-title":"Lancet"},{"key":"15_CR3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1056\/NEJM200101113440207","volume":"344","author":"LM DeAngelis","year":"2001","unstructured":"DeAngelis LM (2001) Brain tumors. N Engl J Med 344: 114\u2013124","journal-title":"N Engl J Med"},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/bjc.1997.147","volume":"75","author":"AM Massimo Di","year":"1997","unstructured":"Di Massimo AM, Di Loreto M, Pacilli A et al (1997) Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata. Br J Cancer 75: 822\u2013828","journal-title":"Br J Cancer"},{"key":"15_CR5","first-page":"326","volume":"6","author":"AE Frankel","year":"2000","unstructured":"Frankel AE, Kreitman RJ, Sausville EA (2000) Targeted toxins. Clin Cancer Res 6: 326\u2013334","journal-title":"Clin Cancer Res"},{"issue":"4","key":"15_CR6","first-page":"899","volume":"7","author":"J Guyotat","year":"2000","unstructured":"Guyotat J, Signorelli F, Frappaz D et al (2000) Is reoperation for recurrence of glioblastoma justified? Oncol Rep 7(4): 899\u2013904","journal-title":"Oncol Rep"},{"key":"15_CR7","first-page":"3649","volume":"58","author":"SR Husain","year":"1998","unstructured":"Husain SR, Behari N, Kreitman RJ et al (1998) Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy. Cancer Res 58: 3649\u20133653","journal-title":"Cancer Res"},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1182>3.0.CO;2-N","volume":"92","author":"SR Husain","year":"2001","unstructured":"Husain SR, Joshi BH, Puri RK (2001) Interleukin-13 receptor as a unique target for anti-glioblastoma therapy. Int J Cancer 92: 168\u2013175","journal-title":"Int J Cancer"},{"key":"15_CR9","first-page":"316","volume":"59","author":"W Jin","year":"1999","unstructured":"Jin W, Bi W, Huang ES et al (1999) Glioblastoma cell-specific expression offibroblast growth factor receptor-1 beta requires an intronic repressor ofRNA splicing. Cancer Res 59: 316\u2013519","journal-title":"Cancer Res"},{"key":"15_CR10","first-page":"8058","volume":"61","author":"BH Joshi","year":"2001","unstructured":"Joshi BH, Leland P, Asher A et al (2001) In situ expression of interleukin-4 receptors in human brain tumors and cytotoxicity of a recombinant interleukin-4 (IL-4) cytotoxin in primary glioblastoma cell cultures. Cancer Res 61: 8058\u20138061","journal-title":"Cancer Res"},{"key":"15_CR11","first-page":"1168","volume":"60","author":"BH Joshi","year":"2001","unstructured":"Joshi BH, Plautz GE, Puri RK (2001) Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas. Cancer Res 60: 1168\u20131172","journal-title":"Cancer Res"},{"key":"15_CR12","doi-asserted-by":"publisher","first-page":"6889","DOI":"10.1073\/pnas.91.15.6889","volume":"91","author":"RJ Kreitman","year":"1994","unstructured":"Kreitman RJ, Puri RK, Pastan I (1994) A circularly permuted recombinant interleukin 4 toxin with increased activity. Proc Nat! Acad Sci USA 91: 6889\u20136893","journal-title":"Acad Sci USA"},{"key":"15_CR13","first-page":"3357","volume":"55","author":"RJ Kreitman","year":"1995","unstructured":"Kreitman RJ, Puri RK, Pastan I (1995) Increased antitumor activity of a circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma. Cancer Res 55: 3357\u20133363","journal-title":"Cancer Res"},{"key":"15_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/glia.440150306","volume":"15","author":"SN Kurpad","year":"1995","unstructured":"Kurpad SN, Zhao XG, Wikstrand CJ et al (1995) Tumor antigens in astrocytic gliomas. Glia 15: 244\u2013256","journal-title":"Glia"},{"key":"15_CR15","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3171\/jns.1994.80.3.0520","volume":"80","author":"DW Laske","year":"1994","unstructured":"Laske DW, Ilercil O, Akbasak A et al (1994) Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. J Neurosurg 80: 520\u2013526","journal-title":"J Neurosurg"},{"key":"15_CR16","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1038\/nm1297-1362","volume":"3","author":"DW Laske","year":"1997","unstructured":"Laske DW, Youle RJ, Oldfield EH (1997) Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med 3: 1362\u20131368","journal-title":"Nat Med"},{"key":"15_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/BF00666210","volume":"32","author":"CF LeMaistre","year":"1994","unstructured":"LeMaistre CF, Meneghetti C, Howes L et al (1994) Targeting the EGF receptor in breast cancer treatment. Breast Cancer Res Treat 32: 97\u2013103","journal-title":"Breast Cancer Res Treat"},{"key":"15_CR18","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3171\/jns.1995.82.6.1021","volume":"82","author":"DM Lieberman","year":"1995","unstructured":"Lieberman DM, Laske DW, Morrison PF et al (1995) Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg 82: 1021\u20131029","journal-title":"J Neurosurg"},{"key":"15_CR19","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1006\/cyto.2000.0773","volume":"12","author":"H Liu","year":"2000","unstructured":"Liu H, Prayson RA, Estes ML et al (2000) In vivo expression of the interleukin 4 receptor alpha by astrocytes in epilepsy cerebral cortex. Cytokine 12: 1656\u20131661","journal-title":"Cytokine"},{"key":"15_CR20","first-page":"5631","volume":"56","author":"RK Puri","year":"1996","unstructured":"Puri RK, Hoon DS, Leland P et al (1996) Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. Cancer Res 56: 5631\u20135637","journal-title":"Cancer Res"},{"key":"15_CR21","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/ijc.2910580421","volume":"58","author":"RK Puri","year":"1994","unstructured":"Puri RK, Leland P, Kreitman RJ et al (1994) Human neurological cancer cells Express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein. Int J Cancer 58: 574\u2013581","journal-title":"Int J Cancer"},{"key":"15_CR22","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1006\/cimm.1996.0176","volume":"171","author":"RK Puri","year":"1996","unstructured":"Puri RK, Leland P, Obiri NI et al (1996) An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. Cell Immunol 171: 80\u201386","journal-title":"Cell Immunol"},{"key":"15_CR23","first-page":"1103","volume":"62","author":"SO Rahaman","year":"2002","unstructured":"Rahaman SO, Shrama P, Harbor PC et al (2002) Il-13Ralpha2, a decoy receptor for IL-13 acts as an inhibitor ofIL-4-dependent signal transudation in glioblastoma cells. Cancer Res 62: 1103\u20131109","journal-title":"Cancer Res"},{"key":"15_CR24","first-page":"2157","volume":"6","author":"RW Rand","year":"2000","unstructured":"Rand RW, Kreitman RJ, Patronas N et al (2000) Intratumoral administration of recombinant circularly permuted interleukin4-Pseudomonas exotoxin in patients with high-grade glioma. Clin Cancer Res 6: 2157\u20132165","journal-title":"Clin Cancer Res"},{"key":"15_CR25","first-page":"14","volume":"1","author":"TS Surawicz","year":"1999","unstructured":"Surawicz TS et al (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990\u20131994. Neurooncology 1: 1990\u20131994","journal-title":"Neurooncology"}],"container-title":["Local Therapies for Glioma Present Status and Future Developments"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-7091-6090-9_15.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T09:23:05Z","timestamp":1606123385000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-7091-6090-9_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"ISBN":["9783211403556","9783709160909"],"references-count":25,"URL":"https:\/\/doi.org\/10.1007\/978-3-7091-6090-9_15","relation":{},"subject":[],"published":{"date-parts":[[2003]]}}}