{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T08:49:04Z","timestamp":1794386944917,"version":"4.9.0"},"publisher-location":"Vienna","reference-count":22,"publisher":"Springer Vienna","isbn-type":[{"value":"9783211837962","type":"print"},{"value":"9783709161395","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002]]},"DOI":"10.1007\/978-3-7091-6139-5_6","type":"book-chapter","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T06:14:51Z","timestamp":1303884891000},"page":"61-67","source":"Crossref","is-referenced-by-count":11,"title":["Can small-vessel disease-related cerebral abnormalities be used as a surrogate marker for vascular dementia trials?"],"prefix":"10.1007","author":[{"given":"F.","family":"Fazekas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ropele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"3","key":"6_CR1","first-page":"S30","volume":"13","author":"J Bowler","year":"1999","unstructured":"Bowler J, Steenhuis R, Hachinski V (1999) Conceptual background to vascular cognitive impairment. Alzheimer Dis Assoc Disord 13[Suppl 3]: S30\u2013S37","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"6_CR2","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1212\/WNL.54.5.1139","volume":"54","author":"M Cercignani","year":"2000","unstructured":"Cercignani M, Iannucci G, Rocca M, Comi G, Horsfield M, Filippi M (2000) Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI. Neurology 54: 1139\u20131144","journal-title":"Neurology"},{"key":"6_CR3","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/S0733-8619(05)70234-6","volume":"18","author":"H Chui","year":"2000","unstructured":"Chui H (2000) Vascular dementia, a new beginning: shifting focus from clinical phenotype to ischemic brain injury. Neurol Clin 18: 951\u2013978","journal-title":"Neurol Clin"},{"key":"6_CR4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1212\/WNL.42.3.473","volume":"42","author":"H Chui","year":"1992","unstructured":"Chui H, Victoroff J, Margolin D, Jagust W, Shankle R, Katzman R (1992) Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer\u2019s Disease Diagnostic and Treatment Centers. Neurology 42: 473\u2013480","journal-title":"Neurology"},{"issue":"3","key":"6_CR5","first-page":"S21","volume":"13","author":"D Desmond","year":"1999","unstructured":"Desmond D, Erkinjuntti T, Sano M, Cummings J, Bowler J, Pasquier F,Moroney J, Ferris S, Stern Y, Sachdev P, Hachinski V (1999) The cognitive syndrome of vascular dementia: implications for clinical trials. Alzheimer Dis Assoc Disord 13[Suppl 3]: S21\u2013S29","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"6_CR6","first-page":"3262","volume":"90","author":"T Erkinjuntti","year":"2000","unstructured":"Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Desmond D (2000) Limitations of clinical criteria for the diagnossis of vascular dementia in clinical trials: is focus on subcortical vascular dementia a solution? Ann NY Acad Sci 90: 3262\u20133272","journal-title":"Ann NY Acad Sci"},{"key":"6_CR7","first-page":"45","volume":"59","author":"F Fazekas","year":"2000","unstructured":"Fazekas F, Ropele S, Bammer R, Kapeller P, Stollberger R, Schmidt R (2000) Novel imaging technologies in the assessment of cerebral ageing and vascular dementia. J Neural Transm [Suppl] 59: 45\u201352","journal-title":"J Neural Transm"},{"key":"6_CR8","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/ana.410430414","volume":"43","author":"M Filippi","year":"1998","unstructured":"Filippi M, Horsfield M, Ader H, Barkhof F, Bruzzi P, Evans A, Frank J, Grossman R, McFarland H, Molyneux P, Paty D, Simon J, Tofts P, Wolinsky J, Miller D (1998) Guidelines for using quantitative measures of brain magnetic resonance imaging abnomrmalities in monitoring the treatment of multiple sclerosis. Ann Neurol 43: 499\u2013506","journal-title":"Ann Neurol"},{"key":"6_CR9","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1212\/WNL.54.4.807","volume":"54","author":"N Fox","year":"2000","unstructured":"Fox N, Jenkins R, Leary S, Stevenson V, LosseffN, CrumW, Harvey R, Rossor M, Miller D, Thompson A (2000) Progressive cerebral atrophy in MS: a serial study using registered, volumetric MRI. Neurology 54: 807\u2013812","journal-title":"volumetric MRI. Neurology"},{"key":"6_CR10","first-page":"1235","volume":"21","author":"H Hanyu","year":"2000","unstructured":"Hanyu H, Asano T, Iwamoto T, Takasaki M, Shindo H, Abe H (2000) Magnetization transfer measurements of the hippocampus in patients with Alzheimer\u2019s disease, vascular dementia, and other types of dementia. AJNR Am J Neuroradiol 21: 1235\u2013242","journal-title":"AJNR Am J Neuroradiol"},{"key":"6_CR11","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1212\/WNL.57.7.1216","volume":"57","author":"H Henon","year":"2001","unstructured":"Henon H, Durieu I, Guerouaou D, Lebert F, Pasquier F, Leys D (2001) Poststroke dementia: incidence and relationship to prestroke cognitive decline. Neurology 57:1216\u20131222","journal-title":"Neurology"},{"key":"6_CR12","first-page":"3510","volume":"90","author":"D Inzitari","year":"2000","unstructured":"Inzitari D, Erkinjuntti T, Wallin A, Del Ser T, Romanelli M, Pantoni L (2000) Subcortical vascular dementia as a specific target for clinical trials. Ann NY Acad Sci 90: 3510\u20133521","journal-title":"Ann NY Acad Sci"},{"key":"6_CR13","first-page":"658","volume":"60","author":"K Jellinger","year":"2001","unstructured":"Jellinger K (2001) Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol 60: 658\u2013659","journal-title":"J Neuropathol Exp Neurol"},{"key":"6_CR14","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s004150050007","volume":"247","author":"P Molyneux","year":"2000","unstructured":"Molyneux P, Miller D, Filippi M, Yousry T, Kappos L, Gasperini C, Ader H, Barkhof F (2000) The use of magnetic resonance imaging in multiple sclerosis treatment trials: power calculations for annual lesion load measurement. J Neurol 247: 34\u201340","journal-title":"J Neurol"},{"key":"6_CR15","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1001\/archneur.57.9.1295","volume":"57","author":"T Pohjasvaara","year":"2000","unstructured":"Pohjasvaara T, Mantyla R, Salonen 0, Aronen H, Ylikoski R, Hietanen M, Kaste M, Erkinjuntti T (2000) How complex interactions of ischemic brain infarcts, white matter lesions, and atrophy relate to poststroke dementia. Arch Neurol 57: 1295\u20131300","journal-title":"Arch Neurol"},{"key":"6_CR16","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.1161\/01.STR.31.12.2952","volume":"31","author":"T Pohjasvaara","year":"2000","unstructured":"Pohjasvaara T, Mantyla R, Ylikoski R, Kaste M, Erkinjuntti T (2000) Comparison of different clinical criteria (DSM-II1, ADDTC, ICD~lO, NINDS-AIREN, DSM-IV) for the diagnosis of vascular dementia. National Institute of Neurological Disorders and Stroke-Associahtion Internationale pour la Recherche et l\u2019Enseignement en Neurosciences. Stroke 31: 2952\u20132957","journal-title":"Stroke"},{"key":"6_CR17","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1212\/WNL.54.2.447","volume":"54","author":"K Rockwood","year":"2000","unstructured":"Rockwood K, Wentzel C, Hachinski V, Hogan D, MacKnight C, McDowell I (2000) Prevalence and outcomes of vascular cognitive impairment. Vascular Cognitive Impairment Investigators of the Canadian Study of Health and Ageing. Neurology 54: 447\u2013451","journal-title":"Neurology"},{"key":"6_CR18","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1212\/WNL.43.2.250","volume":"43","author":"G Roman","year":"1993","unstructured":"Roman G, Tatemichi T, Erkinjuntti T, Cummings J, Masdeu J, Garcia J, Arnaducci L, Orgogozo J, Brun A, Hofman A, Moody D, O\u2019Brien M, Yamaguchi T, Grafman J, Drayer B, Bennett D, Fisher M, Ogata J, Kokmen E, et al (1993) Vascular dementia:Small-vessel disease-related cerebral abnormalities 67 diagnostic criteria for research studies. Report of the NINDS-AIREN International Work Group. Neurology 43: 250\u2013260","journal-title":"Neurology"},{"key":"6_CR19","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1161\/01.STR.31.11.2665","volume":"31","author":"G Roob","year":"2000","unstructured":"Roob G, Lechner A, Schmidt R, Flooh E, Hartung H, Fazekas F. (2000) Frequency and location ofmicrobleeds in patients with primary intracerebral hemorrhage. Stroke 31:2665\u20132669","journal-title":"Stroke"},{"key":"6_CR20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1212\/WNL.53.1.132","volume":"53","author":"R Schmidt","year":"1999","unstructured":"Schmidt R, Fazekas F, Kapeller P, Schmidt H, Hartung H (1999) MRI white matter hyperintensities: three-year follow-up of the Austrian Stroke Prevention Study. Neurology 53: 132\u2013139","journal-title":"Neurology"},{"key":"6_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1212\/WNL.51.1.319","volume":"51","author":"J Veldink","year":"1998","unstructured":"Veldink J, Scheltens P, Jonker C, LJ L (1998) Progression of cerebral white matter hyperintensities on MRI is related to diastolic blood pressure. Neurology 51: 319\u2013320","journal-title":"Neurology"},{"key":"6_CR22","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/0730-725X(96)00098-7","volume":"14","author":"L Wahlund","year":"1996","unstructured":"Wahlund L, Almkvist 0, Basun H, Julin P (1996) MRI in successful ageing, a 5-year follow-up study from eighth to ninth decade of life. Magn Res Imag 14: 601\u2013608","journal-title":"Magn Res Imag"}],"container-title":["Journal of Neural Transmission. Supplementa","Ageing and Dementia Current and Future Concepts"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-7091-6139-5_6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T04:30:08Z","timestamp":1558845008000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-7091-6139-5_6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"ISBN":["9783211837962","9783709161395"],"references-count":22,"URL":"https:\/\/doi.org\/10.1007\/978-3-7091-6139-5_6","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-3-7091-6139-5","asserted-by":"object"}]},"ISSN":["0303-6995"],"issn-type":[{"value":"0303-6995","type":"print"}],"subject":[],"published":{"date-parts":[[2002]]}}}