{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T04:16:41Z","timestamp":1778991401964,"version":"3.51.4"},"publisher-location":"Vienna","reference-count":46,"publisher":"Springer Vienna","isbn-type":[{"value":"9783211833773","type":"print"},{"value":"9783709163801","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999]]},"DOI":"10.1007\/978-3-7091-6380-1_14","type":"book-chapter","created":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T04:38:37Z","timestamp":1307594317000},"page":"221-232","source":"Crossref","is-referenced-by-count":6,"title":["Serotonin (5-HT) in brains of adult patients with Down Syndrome"],"prefix":"10.1007","author":[{"given":"R.","family":"Seidl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. T.","family":"Kaehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Prast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Singewald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gratzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lubec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"14_CR1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000213319","volume":"38","author":"A Andersson","year":"1992","unstructured":"Andersson A, Sundman I, Marcusson J (1992) Age stability of human brain 5-HT terminals studied with 3H paroxetine binding. Gerontol 38: 127\u2013132","journal-title":"Gerontol"},{"issue":"[Suppl 12]","key":"14_CR2","first-page":"4","volume":"52","author":"E Azmitia","year":"1991","unstructured":"Azmitia E, Whitaker-Azmitia P (1991) Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system. J Clin Psychiatry 52 [Suppl 12]: 4\u201316","journal-title":"J Clin Psychiatry"},{"key":"14_CR3","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/S0140-6736(67)91708-4","volume":"i","author":"M Bazelon","year":"1967","unstructured":"Bazelon M, Paine RS, Coeiw VA, Hunt P, Houck JC, Mahanand D (1967) Reversal of hypotonia in infants with Down\u2019s syndrome by administration of 5-hydroxytry-ptophan. Lancet i: 1130\u20131133","journal-title":"Lancet"},{"key":"14_CR4","first-page":"133","volume":"373","author":"LE Becker","year":"1991","unstructured":"Becker LE, Mito T, Takashima S, Onodera K (1991) Growth and development of the brain in Down syndrome. Prog Clin Biol Res 373: 133\u2013152","journal-title":"Prog Clin Biol Res"},{"key":"14_CR5","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1046\/j.1471-4159.1995.64020749.x","volume":"64","author":"LM Bierer","year":"1995","unstructured":"Bierer LM, Haroutunian V, Gabriel S, Knott PJ, Carlin LS, Purohit DP, Perl DP, Schmeidler J, Kanof P, Davis KL (1995) Neurochemical correlates of dementia severity in Alzheimer\u2019s disease: relative importance of the cholinergic deficits. J Neurochem 64: 749\u2013760","journal-title":"J Neurochem"},{"key":"14_CR6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0166-2236(94)90091-4","volume":"17","author":"BB Bowen","year":"1994","unstructured":"Bowen BB, Francis PT, Chessel IP, Webster MT (1994) Neurotransmission-the link integrating Alzheimer\u2019s disease? Trends Neurosci 17: 149\u2013150","journal-title":"Trends Neurosci"},{"key":"14_CR7","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S0006-3223(98)00202-9","volume":"44","author":"RC Casper","year":"1998","unstructured":"Casper RC (1998) Serotonin, a major player in regulation of feeding and affect. Biol Psychiatry 44: 795\u2013797","journal-title":"Biol Psychiatry"},{"key":"14_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/BF00166940","volume":"347","author":"P Celeda","year":"1993","unstructured":"Celeda P, Artigas F (1993) Effects of local and systemic MAO inhibitors on extracellular brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the frontal cortex and raphe nuclei of freely moving rats. An in vivo microdialysis study. Naunyn Schmiedebergs Arch Pharmacol 347: 583\u2013590","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"14_CR9","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1046\/j.1471-4159.1996.66041592.x","volume":"66","author":"CP Chen","year":"1996","unstructured":"Chen CP, Alder JT, Bowen DM, Esiri MM, McDonald B, Hope T, Jobst KA, Francis PT (1996) Presynaptic serotonergic markers in community-acquired cases of Alzheimer\u2019s disease: correlations with depression and neuroleptic medication. J Neurochem 66:1592\u20131598","journal-title":"J Neurochem"},{"key":"14_CR10","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1212\/WNL.21.9.911","volume":"21","author":"M Coleman","year":"1971","unstructured":"Coleman M (1971) Infantile spasms associated with 5-hydroxytryptophan administered in patients with Down\u2019s syndrome. Neurol 21: 911","journal-title":"Neurol"},{"key":"14_CR11","first-page":"749","volume-title":"The metabolic and molecular bases of inherited disease","author":"CJ Epstein","year":"1995","unstructured":"Epstein CJ (1995) Down Syndrome (Trisomy 21). In: Scriver SR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 749\u2013794"},{"key":"14_CR12","first-page":"263","volume-title":"Basic neurochemistry, molecular, cellular and medical aspects","author":"A Frazer","year":"1999","unstructured":"Frazer A, Hensler JG (1999) Serotonin. In: Siegel GJ, Agranoff BW, Albers RW, Fisher SK, Uhler MD (eds) Basic neurochemistry, molecular, cellular and medical aspects, 6th edn. Lippincott Raven, Philadelphia New York, pp 263\u2013293","edition":"6"},{"key":"14_CR13","first-page":"195","volume":"34","author":"A Gedye","year":"1990","unstructured":"Gedye A (1990) Dietary increase in serotonin reduces self-injurious behaviour in a Down\u2019s syndrome adult. J Ment Defic Res 34: 195","journal-title":"J Ment Defic Res"},{"key":"14_CR14","first-page":"247","volume":"35","author":"A Gedye","year":"1991","unstructured":"Gedye A (1991) Serotonergic treatment for aggression in a Down\u2019s syndrome adult showing signs of Alzheimer\u2019s disease. J Ment Defic Res 35: 247\u2013258","journal-title":"J Ment Defic Res"},{"key":"14_CR15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/089198879701000302","volume":"10","author":"DS Geldmacher","year":"1997","unstructured":"Geldmacher DS, Lerner AJ, Voci JM, Noelker EA, Somple LC, Whitehouse PJ (1997) Treatment of functional decline in adults with Down syndrome using seletive serotonin-reuptake inhibitor drugs. J Geriatr Psychiat Neurol 10: 99\u2013104","journal-title":"J Geriatr Psychiat Neurol"},{"key":"14_CR16","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1136\/jnnp.50.6.775","volume":"50","author":"H Godridge","year":"1987","unstructured":"Godridge H, Reynolds GP, Czudek C, Calcutt NA, Benton M (1987) Alzheimer-like neurotransmitter deficits in adult Down\u2019s syndrome brain tissue. J Neurol Neurosurg Psychiatry 50: 775\u2013778","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"14_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0197-4580(83)90002-7","volume":"4","author":"CG Gottfries","year":"1983","unstructured":"Gottfries CG, Adolfsson R, Aquilonius SM, Carlsson A, Eckernas SA, Nordberg A, Oreland L, Svennerholm L, Wiberg A, Winblad B (1983) Biochemical changes in dementia disorders of Alzheimer type (AD\/SDAT). Neurobiol Aging 4: 261\u2013271","journal-title":"Neurobiol Aging"},{"key":"14_CR18","first-page":"193","volume":"33","author":"JV Haxby","year":"1989","unstructured":"Haxby JV (1989) Neuropsychological evaluation of adults with Down\u2019s syndrome: patterns of selective impairment in nondemented old adults. J Ment Defic Res 33: 193\u2013197","journal-title":"J Ment Defic Res"},{"key":"14_CR19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1001\/archneur.1997.00550140025008","volume":"54","author":"K Holthoff-Detto","year":"1997","unstructured":"Holthoff-Detto K, Kessler J, Herholz K, Bonner H, Pietrzyk U, Wurker M, Ghaemi M, Wienhard K, Wagner R, Heiss WD (1997) Functional effects of striatal dysfunction in Parkinson disease. Arch Neurol 54: 145\u2013150","journal-title":"Arch Neurol"},{"key":"14_CR20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","volume":"72","author":"BL Jacobs","year":"1992","unstructured":"Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72: 165\u2013229","journal-title":"Physiol Rev"},{"key":"14_CR21","first-page":"461","volume-title":"Psychopharmacology: the fourth generation of progess","author":"B Jacobs","year":"1995","unstructured":"Jacobs B, Fornai C (1995) Serotonin and behavior, a general hypothesis. In: Bloom F, Kupfer D (eds) Psychopharmacology: the fourth generation of progess. Raven Press, New York, pp 461\u2013469"},{"key":"14_CR22","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0166-2236(93)90162-F","volume":"16","author":"JM Lauder","year":"1993","unstructured":"Lauder JM (1993) Neurotransmitters as growth regulatory signals: role of receptors and second messengers. Trends Neurosci 16: 233\u2013240","journal-title":"Trends Neurosci"},{"key":"14_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0006-3223(98)00121-8","volume":"44","author":"KP Lesch","year":"1998","unstructured":"Lesch KP, M\u00f6ssner R (1998) Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental and neurodgenerative disorders? Biol Psychiatry 44: 179\u2013192","journal-title":"Biol Psychiatry"},{"key":"14_CR24","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1097\/00001756-199702100-00021","volume":"8","author":"T Li","year":"1997","unstructured":"Li T, Holmes C, Sham PC, Vallada H, Birkett J, Kirov G (1997) Allelic functional variation of serotonin transporter expression is a susceptibility factor for late-onset Alzheimer\u2019s disease. Neuroreport 8: 683\u2013686","journal-title":"Neuroreport"},{"key":"14_CR25","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0006-3223(98)00139-5","volume":"44","author":"I Lucki","year":"1998","unstructured":"Lucki I (1998) The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44: 151\u2013162","journal-title":"Biol Psychiatry"},{"key":"14_CR26","first-page":"147","volume":"5","author":"DMA Mann","year":"1986","unstructured":"Mann DMA, Yates PO (1986) Neurotransmitter deficits in Alzheimer\u2019s disease and in other dementing disorders. Hum Neurobiol 5: 147\u2013158","journal-title":"Hum Neurobiol"},{"key":"14_CR27","first-page":"125","volume":"29","author":"DMA Mann","year":"1985","unstructured":"Mann DMA, Yates PO, Marcyniuk B, Ravindra CR (1985) Pathological evidence for neurotransmitter deficits in Down\u2019s syndrome of middle age. J Ment Defic Res 29: 125\u2013135","journal-title":"J Ment Defic Res"},{"key":"14_CR28","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0022-510X(90)90152-D","volume":"99","author":"DMA Mann","year":"1990","unstructured":"Mann DMA, Royston MC, Ravindra CR (1990) Some morphological observations on the brains of patients with Down\u2019s syndrome: their relationship to age and dementia. J Neurol Sci 99: 153","journal-title":"J Neurol Sci"},{"key":"14_CR29","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1212\/WNL.41.4.479","volume":"41","author":"SS Mirra","year":"1991","unstructured":"Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ (1991) The consortium to establish a registry for Alzheimer\u2019s disease (CERAD). II. Standardisation of the neuropatho-logical assessment of Alzheimer\u2019s Disease. Neurol 41: 479\u2013486","journal-title":"Neurol"},{"key":"14_CR30","volume-title":"Down Syndrome and Alzheimer disease","year":"1992","unstructured":"Nadel L, Epstein CJ (eds) (1992) Down Syndrome and Alzheimer disease. Wiley-Liss, New York (Prog Clin Biol Res 379)"},{"key":"14_CR31","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/ana.410230616","volume":"23","author":"AM Palmer","year":"1988","unstructured":"Palmer AM, Stratmann GC, Procter AW, Bowen DM (1988) Possible neurotransmitter basis of behavioral changes in Alzheimer\u2019s disease. Ann Neurol 23: 616\u2013620","journal-title":"Ann Neurol"},{"key":"14_CR32","first-page":"193","volume-title":"Neurobiolgy of Alzheimer disease","author":"AW Procter","year":"1995","unstructured":"Procter AW, Francis PT, Chen CPLH, Chessel IP, Dijk S, Clarke NA, Webster MT, Bowen DM (1995) The neurochemical pathology of Alzheimer\u2019s disease. In: Allen SJ, Dawbarn D (eds) Neurobiolgy of Alzheimer disease. BIOS Scientific Publ, Oxford, pp 193\u2013221"},{"key":"14_CR33","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1016\/S0140-6736(85)92666-2","volume":"ii","author":"GP Reynolds","year":"1985","unstructured":"Reynolds GP, Godridge H (1985) Alzheimer-like brain monoamine deficits in adults with Down\u2019s syndrome. Lancet ii: 1368\u20131369","journal-title":"Lancet"},{"key":"14_CR34","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0024-3205(97)00067-2","volume":"60","author":"D Risser","year":"1997","unstructured":"Risser D, Lubec G, Cairns N, Herrera-Marschitz M (1997) Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome. Life Sci 60: 1231\u20131237","journal-title":"Life Sci"},{"key":"14_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0047-6374(94)01525-Q","volume":"77","author":"JA Rodriguez-Gomez","year":"1995","unstructured":"Rodriguez-Gomez JA, de la Roza C, Machado A, Cano J (1995) The effect of age on the monoamines of the hypothalamus. Mech Ageing Dev 77: 185\u2013195","journal-title":"Mech Ageing Dev"},{"key":"14_CR36","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/j.1460-9568.1997.tb01632.x","volume":"9","author":"N Singewald","year":"1997","unstructured":"Singewald N, Kaehler S, Hemeida R, Philippu A (1997) Release of serotonin in the rat locus coeruleus: effects of cardiovascular, stressful and noxious stimuli. Eur J Neurosci 9: 556\u2013562","journal-title":"Eur J Neurosci"},{"key":"14_CR37","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0006-3223(98)00185-1","volume":"44","author":"JK Staley","year":"1998","unstructured":"Staley JK, Malison RT, Innis RB (1998) Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biol Psychiatry 44: 534\u2013549","journal-title":"Biol Psychiatry"},{"key":"14_CR38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1212\/WNL.38.3.359","volume":"38","author":"MC Tierney","year":"1998","unstructured":"Tierney MC, Fisher RH, Lewis AJ, Torzitto ML, Snow WG, Reid DW, Nieuwstraten P, Van Rooijen LAA, Derks HJGM, Van Wijk R, Bischop A (1998) The NINCDA-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer\u2019s disease. Neurol 38: 359\u2013364","journal-title":"Neurol"},{"issue":"7415","key":"14_CR39","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S0140-6736(65)90454-X","volume":"ii","author":"JB Tu","year":"1965","unstructured":"Tu JB, Zellweger H (1965) Blood-serotonin deficiency in Down\u2019s syndrome. Lancet ii(7415): 715\u2013716","journal-title":"Lancet"},{"key":"14_CR40","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1192\/bjp.155.2.202","volume":"155","author":"AC Warren","year":"1989","unstructured":"Warren AC, Holroyd S, Folstein P (1989) Major depression in Down\u2019s syndrome. Br J Psychiatry 155: 202\u2013207","journal-title":"Br J Psychiatry"},{"key":"14_CR41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1542\/peds.54.2.165","volume":"54","author":"P Weise","year":"1974","unstructured":"Weise P, Koch R, Shaw KNF, Rosenfeld MJ (1974) The use of 5-HTP in the treatment of Down\u2019s syndrome. Pediatr 54: 165\u2013167","journal-title":"Pediatr"},{"key":"14_CR42","first-page":"289","volume":"7","author":"KE Wisniewski","year":"1994","unstructured":"Wisniewski KE, Kida E (1994) Abnormal neurogenesis and synaptogenesis in Down syndrome brain. Dev Brain Dysfunct 7: 289\u2013301","journal-title":"Dev Brain Dysfunct"},{"key":"14_CR43","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/ana.410170310","volume":"17","author":"KE Wisniewski","year":"1985","unstructured":"Wisniewski KE, Wisniewski HM, Wen GY (1985) Occurrence of neuropathological changes and dementia of Alzheimer\u2019s disease in Down syndrome. Ann Neurol 17: 278\u2013282","journal-title":"Ann Neurol"},{"key":"14_CR44","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0140-6736(80)92137-6","volume":"1st","author":"CM Yates","year":"1980","unstructured":"Yates CM, Simpson J, Maloney AFJ, Gordon A, Reid AH (1980) Alzheimer-like cholinergic deficiency in Down syndrome. Lancet Nov 1st: 979","journal-title":"Lancet Nov"},{"key":"14_CR45","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0006-8993(83)91179-4","volume":"280","author":"CM Yates","year":"1983","unstructured":"Yates CM, Simpson J, Gordon A, Maloney AFJ, Allison Y, Ritchie IM, Urquhart A (1983) Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down\u2019s syndrome. Brain Res 280: 119\u2013126","journal-title":"Brain Res"},{"key":"14_CR46","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0304-3940(86)90302-2","volume":"65","author":"CM Yates","year":"1986","unstructured":"Yates CM, Simpson J, Gordon A (1986) Regional brain 5-hydroxytryptamine levels are reduced in senile Down\u2019s syndrome as in Alzheimer\u2019s disease. Neurosci Lett 65:189\u2013192","journal-title":"Neurosci Lett"}],"container-title":["The Molecular Biology of Down Syndrome"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-7091-6380-1_14.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T11:34:17Z","timestamp":1712489657000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-7091-6380-1_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"ISBN":["9783211833773","9783709163801"],"references-count":46,"URL":"https:\/\/doi.org\/10.1007\/978-3-7091-6380-1_14","relation":{},"subject":[],"published":{"date-parts":[[1999]]}}}