{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T19:55:00Z","timestamp":1794426900557,"version":"4.9.1"},"publisher-location":"Vienna","reference-count":34,"publisher":"Springer Vienna","isbn-type":[{"value":"9783709173121","type":"print"},{"value":"9783709163917","type":"electronic"}],"license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999]]},"DOI":"10.1007\/978-3-7091-6391-7_15","type":"book-chapter","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T19:50:04Z","timestamp":1343505004000},"page":"89-92","source":"Crossref","is-referenced-by-count":49,"title":["Apolipoprotein E and the Response of the Brain to Injury"],"prefix":"10.1007","author":[{"given":"D. I.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Horsburgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. R.","family":"Nicoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Teasdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"15_CR1","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/42257","volume":"388","author":"SW Barger","year":"1997","unstructured":"Barger SW, Harmon RE (1997) Microglial activation by Alzheimer amyloid precursor protein and modulation of apolipo-protein E. Nature 388: 878\u2013881","journal-title":"Nature"},{"key":"15_CR2","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1006\/exnr.1996.0064","volume":"138","author":"LM Fleming","year":"1996","unstructured":"Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV (1996) Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Exp Neurol 138: 252\u2013260","journal-title":"Exp Neurol"},{"key":"15_CR3","first-page":"526","volume":"145","author":"G Gallo","year":"1994","unstructured":"Gallo G, Wisniewski T, Choi-Miura NH, Ghiso J, Frangione B (1994) Potential role of apolipoprotein-E in fibrillogenesis. Am J Pathol 145: 526\u2013530","journal-title":"Am J Pathol"},{"key":"15_CR4","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1097\/00001756-199704140-00039","volume":"8","author":"SM Gentleman","year":"1997","unstructured":"Gentleman SM, Greenberg BD, Savage MJ (1997) A\u00df42 is the predominant form of amyloid \u00df-protein in the brains of short-term survivors of head injury. Neuroreport 8: 1519\u20131572","journal-title":"Neuroreport"},{"key":"15_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1365-2990.1995.tb01025.x","volume":"21","author":"DI Graham","year":"1995","unstructured":"Graham DI, Gentleman SM, Lynch A, Roberts GW (1995) Distribution of \u03b2-amyloid protein in the brain following severe head injury. Neuropath Appl Neurobiol 21: 27\u201334","journal-title":"Neuropath Appl Neurobiol"},{"key":"15_CR6","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1161\/01.STR.27.8.1333","volume":"27","author":"SM Greenberg","year":"1996","unstructured":"Greenberg SM, Briggs ME, Hyman BT, Kokoris GJ, Takis C, Kanter DS, Kase CS, Pessin MS (1996) Apolipoprotein E epi-solin 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke 27: 1333\u20131337","journal-title":"Stroke"},{"key":"15_CR7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0165-6147(91)90609-V","volume":"12","author":"J Hardy","year":"1991","unstructured":"Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer\u2019s disease. Trends Pharmacol Sci 12: 383\u2013388","journal-title":"Trends Pharmacol Sci"},{"key":"15_CR8","doi-asserted-by":"publisher","first-page":"9480","DOI":"10.1073\/pnas.92.21.9480","volume":"92","author":"DM Holtzman","year":"1995","unstructured":"Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL (1995) Low density lipoprotein receptor-related protein mediates apolipoprotein E dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci USA 92: 9480\u20139484","journal-title":"Proc Natl Acad Sci USA"},{"key":"15_CR9","unstructured":"Horsburgh K, Kelly S, McCulloch J, Higgins G, Roses AD, Nicoll JAR (1998) Apolipoprotein E deficient mice have increased neuronal damage following global ischaemia. Neurobiol Aging (abs)"},{"key":"15_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1001\/jama.1997.03550020068040","volume":"278","author":"BD Jordan","year":"1997","unstructured":"Jordan BD, Relkin NR, Ravdin LD, Jacobs AR, Bennett A, Gandy S (1997) Apolipoprotein E epsilon-4 associated with chronic traumatic brain injury in boxing. JAMA 278: 136\u2013140","journal-title":"JAMA"},{"key":"15_CR11","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/00004647-199707000-00005","volume":"17","author":"DT Laskowitz","year":"1997","unstructured":"Laskowitz DT, Sheng H, Bvart R, Joyner K, Roses AD, Warner D (1997) Apolipoprotein E deficient mice have increased susceptibility to focal cerebral ischemia. J Cereb Blood Flow Metab 17: 753\u2013758","journal-title":"J Cereb Blood Flow Metab"},{"key":"15_CR12","first-page":"70","volume":"76","author":"DT Lasowitz","year":"1997","unstructured":"Lasowitz DT, Goel S, Bennett ER, Matthew WD (1997) Apolipoprotein E suppresses glial cell secretion of TNF\u03b1. J Neuro-immunol 76: 70\u201374","journal-title":"J Neuro-immunol"},{"key":"15_CR13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/372092a0","volume":"372","author":"J Ma","year":"1994","unstructured":"Ma J, Yee A, Brewer HB Jr, Das S, Potter H (1994) Amyloid-associated proteins alpha-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 372: 92","journal-title":"Nature"},{"key":"15_CR14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1002\/ana.410330513","volume":"33","author":"R Mayeux","year":"1993","unstructured":"Mayeux R, Ottman R, Rang MX, Noboa Banza L, Marer K, Gurland B, Stern Y (1993) Genetic susceptibility and head injury as risk factors for Alzheimer\u2019s disease among community-dwelling elderly persons and their first-degree relatives. Ann Neurol 33: 494\u2013501","journal-title":"Ann Neurol"},{"key":"15_CR15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ng0996-55","volume":"14","author":"M Miyata","year":"1996","unstructured":"Miyata M, Smith JD (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet 14: 55\u201361","journal-title":"Nat Genet"},{"key":"15_CR16","first-page":"3","volume-title":"Research advances in Alzheimer\u2019s disease and related disorders","author":"JA Mortimer","year":"1995","unstructured":"Mortimer JA (1995) The epidemiology of Alzheimer\u2019s disease: beyond risk factors. In: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM (eds) Research advances in Alzheimer\u2019s disease and related disorders. John Wiley & Sons, Chichester, New York, pp 3\u201313"},{"key":"15_CR17","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1093\/ije\/20.Supplement_2.S28","volume":"2","author":"JA Mortimer","year":"1991","unstructured":"Mortimer JA, van Duijn CM, Chandra V (1991) Head trauma as a risk factor for Alzheimer\u2019s disease: a collaborative re-analysis of case-controlled studies. Int J Epidemiol 20 [Suppl] 2:S28\u2013S35","journal-title":"Int J Epidemiol 20 [Suppl]"},{"key":"15_CR18","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1016\/0003-4975(95)00076-W","volume":"59","author":"MF Newman","year":"1995","unstructured":"Newman MF, Croughwell ND, Blumenthall JA, Lowry E, White WD, Spillane W, Davis RD, Glower DD, Smith LR, Mahanna EP (1995) Predictors of cardiac decline after cardiac operation. Ann Thorac Surg 59: 1326\u20131330","journal-title":"Ann Thorac Surg"},{"key":"15_CR19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/ana.410390521","volume":"39","author":"JA Nicoll","year":"1996","unstructured":"Nicoll JA, Burnett C, Love S, Graham DI, Ironside JW, Vinters HV (1996) High frequency of apolipoprotein E epsilon 2 in patients with cerebral hemorrhage due to cerebral amyloid angiopathy. Ann Neurol 39: 682\u2013683","journal-title":"Ann Neurol"},{"key":"15_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nm0295-135","volume":"1","author":"JAR Nicoll","year":"1995","unstructured":"Nicoll JAR, Roberts GW, Graham DI (1995) Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nature Med 1: 135\u2013137","journal-title":"Nature Med"},{"key":"15_CR21","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/0166-2236(94)90156-2","volume":"17","author":"J Poirier","year":"1994","unstructured":"Poirier J (1994) Apolipoprotein E in animal models of CNS injury and in Alzheimer\u2019s disease. Trends Neurosci 17: 525\u2013530","journal-title":"Trends Neurosci"},{"key":"15_CR22","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1136\/jnnp.57.4.419","volume":"57","author":"GW Roberts","year":"1994","unstructured":"Roberts GW, Gentleman SM, Lynch A, Murray L, Landon M, Graham DI (1994) \u00df-amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer\u2019s disease. J Neurol Neurosurg Psychiatr 57: 419\u2013425","journal-title":"J Neurol Neurosurg Psychiatr"},{"key":"15_CR23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0014-4886(95)90019-5","volume":"132","author":"AD Roses","year":"1995","unstructured":"Roses AD (1995) On the metabolism of apolipoprotein E and the Alzheimer\u2019s diseases. Exp Neurol 132: 149\u2013156","journal-title":"Exp Neurol"},{"key":"15_CR24","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev.med.47.1.387","volume":"47","author":"AD Roses","year":"1996","unstructured":"Roses AD (1996) Apolipoprotein E alleles as risk factors in AD. Ann Rev Med 47: 387\u2013400","journal-title":"Ann Rev Med"},{"key":"15_CR25","first-page":"85","volume-title":"Research advances in Alzheimer\u2019s disease and related disorders","author":"AD Roses","year":"1995","unstructured":"Roses AD, Saunders A, Corder EH, Risch NH, Haines, JL, Pericak-Vance M, Hans SH, Einstein G, Hulette C, Schmechel DE, Goedert M, Jakes R, Dong LM, Weisgraber KH, Holsti M, Huang D, Strittmatter WJ (1995) Apolipoprotein E and Alzheimer\u2019s disease. In: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM (eds) Research advances in Alzheimer\u2019s disease and related disorders. John Wiley & Sons, London, pp 85\u201396"},{"key":"15_CR26","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","volume":"43","author":"AM Saunders","year":"1994","unstructured":"Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance M, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ et al (1994) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer\u2019s disease. Neurology 43: 1467\u20131472","journal-title":"Neurology"},{"key":"15_CR27","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/00005072-199409000-00003","volume":"53","author":"DJ Selkoe","year":"1994","unstructured":"Selkoe DJ (1994) Alzheimer\u2019s disease: a central role for amyloid. J Neuropathol Exp Neurobiol 53: 438\u2013447","journal-title":"J Neuropathol Exp Neurobiol"},{"key":"15_CR28","first-page":"818","volume":"277","author":"AJ Slooter","year":"1997","unstructured":"Slooter AJ, Tang MX, van Duijn CM, Stern Y, Ott A, Bell K, Breteler MM, Van Broeckhoven C, Tatemichi TK, Tycko B, Hofman A, Mayeux R (1997) Apolipoprotein E epsilon 4 and the risk of dementia with stroke. A population-based investigation. JAMA 277: 818\u2013821","journal-title":"A population-based investigation. JAMA"},{"key":"15_CR29","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/nm0995-852","volume":"1","author":"S Sorbi","year":"1995","unstructured":"Sorbi S, Nacmias B, Piacentini S, Repice A, Latorraca S, Forleo P, Amaducci L (1995) ApoE as a prognostic factor for post-traumatic coma. Nature Med 1: 852","journal-title":"Nature Med"},{"key":"15_CR30","doi-asserted-by":"publisher","first-page":"11183","DOI":"10.1073\/pnas.91.23.11183","volume":"91","author":"WJ Strittmatter","year":"1994","unstructured":"Strittmatter WJ, Saunders AM, Goedbert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD (1994) Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer\u2019s disease. Proc Natl Acad Sci USA 91: 11183\u201311186","journal-title":"Proc Natl Acad Sci USA"},{"key":"15_CR31","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","volume":"90","author":"WJ Strittmatter","year":"1993","unstructured":"Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer\u2019s disease. Proc Natl Acad Sci USA 90: 1977\u20131981","journal-title":"Proc Natl Acad Sci USA"},{"key":"15_CR32","doi-asserted-by":"publisher","first-page":"8098","DOI":"10.1073\/pnas.90.17.8098","volume":"90","author":"WJ Strittmatter","year":"1993","unstructured":"Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD (1993) Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer\u2019s disease. Proc Natl Acad Sci USA 90: 8098\u20138102","journal-title":"Proc Natl Acad Sci USA"},{"key":"15_CR33","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/S0140-6736(97)04318-3","volume":"350","author":"GM Teasdale","year":"1997","unstructured":"Teasdale GM, Nicoll, JAR, Murray G, Fiddes M (1997) Association of apolipoprotein E polymorphism with outcome after head injury. Lancet 350: 1069\u20131071","journal-title":"Lancet"},{"key":"15_CR34","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1006\/nbdi.1996.0023","volume":"3","author":"P Xu","year":"1996","unstructured":"Xu, P, Schmechel D, Rothrock-Christian T et al (1996) Human apolipoprotein E2, E3 and E4 isoform specific transgenic mice: human-like pattern of neuronal immunoreactivity in centralnervous system not observed in wildtype mice. Neurobiol Dis 3: 229\u2013245","journal-title":"Neurobiol Dis"}],"container-title":["Acta Neurochirurgica Supplements","Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-3-7091-6391-7_15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T10:34:10Z","timestamp":1558175650000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-3-7091-6391-7_15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"ISBN":["9783709173121","9783709163917"],"references-count":34,"URL":"https:\/\/doi.org\/10.1007\/978-3-7091-6391-7_15","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-3-7091-6391-7","asserted-by":"object"}]},"ISSN":["0065-1419"],"issn-type":[{"value":"0065-1419","type":"print"}],"subject":[],"published":{"date-parts":[[1999]]}}}