{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:35:56Z","timestamp":1791286556483,"version":"4.1.0"},"publisher-location":"Dordrecht","reference-count":194,"publisher":"Springer Netherlands","isbn-type":[{"value":"9789400702646","type":"print"},{"value":"9789400702653","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"DOI":"10.1007\/978-94-007-0265-3_16","type":"book-chapter","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T16:28:38Z","timestamp":1296664118000},"page":"287-313","source":"Crossref","is-referenced-by-count":42,"title":["TRPP Channels and Polycystins"],"prefix":"10.1007","author":[{"given":"Alexis","family":"Hofherr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"K\u00f6ttgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,24]]},"reference":[{"key":"16_CR1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","volume":"426","author":"DE Clapham","year":"2003","unstructured":"Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517\u2013524","journal-title":"Nature"},{"key":"16_CR2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","volume":"76","author":"K Venkatachalam","year":"2007","unstructured":"Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76:387\u2013417","journal-title":"Annu Rev Biochem"},{"key":"16_CR3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00424-005-1429-z","volume":"451","author":"BN Desai","year":"2005","unstructured":"Desai BN, Clapham DE (2005) TRP channels and mice deficient in TRP channels. Pflugers Arch 451:11\u201318","journal-title":"Pflugers Arch"},{"key":"16_CR4","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.physiol.68.040204.100431","volume":"68","author":"IS Ramsey","year":"2006","unstructured":"Ramsey IS, Delling M, Clapham DE (2006) An introduction to TRP channels. Annu Rev Physiol 68:619\u2013647","journal-title":"Annu Rev Physiol"},{"key":"16_CR5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","volume":"4","author":"MJ Berridge","year":"2003","unstructured":"Berridge MJ, Bootman MD, Roderick HL (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4:517\u2013529","journal-title":"Nat Rev Mol Cell Biol"},{"key":"16_CR6","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1046\/j.1432-1033.2001.02500.x","volume":"268","author":"R Jahnel","year":"2001","unstructured":"Jahnel R, Dreger M, Gillen C, Bender O, Kurreck J, Hucho F (2001) Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line. Eur J Biochem 268:5489\u20135496","journal-title":"Eur J Biochem"},{"key":"16_CR7","doi-asserted-by":"crossref","first-page":"28613","DOI":"10.1074\/jbc.M103272200","volume":"276","author":"N Kedei","year":"2001","unstructured":"Kedei N, Szabo T, Lile JD, Treanor JJ, Olah Z, Iadarola MJ, Blumberg PM (2001) Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem 276:28613\u2013 28619","journal-title":"J Biol Chem"},{"key":"16_CR8","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1073\/pnas.0711835105","volume":"105","author":"VY Moiseenkova-Bell","year":"2008","unstructured":"Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG (2008) Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci USA 105:7451\u20137455","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1085\/jgp.200810123","volume":"133","author":"VY Moiseenkova-Bell","year":"2009","unstructured":"Moiseenkova-Bell VY, Wensel TG (2009) Hot on the trail of TRP channel structure. J Gen Physiol 133:239\u2013244","journal-title":"J Gen Physiol"},{"key":"16_CR10","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.272.5266.1339","volume":"272","author":"T Mochizuki","year":"1996","unstructured":"Mochizuki T, Wu G, Hayashi T, Xenophontos SL, Veldhuisen B, Saris JJ, Reynolds DM, Cai Y, Gabow PA, Pierides A, Kimberling WJ, Breuning MH, Deltas CC, Peters DJ, Somlo S (1996) PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 272:1339\u20131342","journal-title":"Science"},{"key":"16_CR11","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1097\/01.ASN.0000028643.17901.42","volume":"13","author":"P Igarashi","year":"2002","unstructured":"Igarashi P, Somlo S (2002) Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol 13:2384\u20132398","journal-title":"J Am Soc Nephrol"},{"key":"16_CR12","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/317542a0","volume":"317","author":"ST Reeders","year":"1985","unstructured":"Reeders ST, Breuning MH, Davies KE, Nicholls RD, Jarman AP, Higgs DR, Pearson PL, Weatherall DJ (1985) A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature 317:542\u2013544","journal-title":"Nature"},{"key":"16_CR13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(94)90137-6","volume":"77","author":"The European Polycystic Kidney Disease Consortium","year":"1994","unstructured":"The European Polycystic Kidney Disease Consortium (1994) The polycystic kidney disease 1 gene encodes a 14\u00a0kb transcript and lies within a duplicated region on chromosome 16. Cell 77:881\u2013894","journal-title":"Cell"},{"key":"16_CR14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0092-8674(95)90339-9","volume":"81","author":"The International Polycystic Kidney Disease Consortium","year":"1995","unstructured":"The International Polycystic Kidney Disease Consortium (1995) Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. Cell 81:289\u2013298","journal-title":"Cell"},{"key":"16_CR15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ki.2009.128","volume":"76","author":"VE Torres","year":"2009","unstructured":"Torres VE, Harris PC (2009) Autosomal dominant polycystic kidney disease: the last 3 years. Kidney Int 76:149\u2013168","journal-title":"Kidney Int"},{"key":"16_CR16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1053\/ajkd.2002.33908","volume":"40","author":"AD Paterson","year":"2002","unstructured":"Paterson AD, Wang KR, Lupea D, St George-Hyslop P, Pei Y (2002) Recurrent fetal loss associated with bilineal inheritance of type 1 autosomal dominant polycystic kidney disease. Am J Kidney Dis 40:16\u201320","journal-title":"Am J Kidney Dis"},{"key":"16_CR17","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/hmg\/11.16.1845","volume":"11","author":"G Wu","year":"2002","unstructured":"Wu G, Tian X, Nishimura S, Markowitz GS, D\u2019Agati V, Park JH, Yao L, Li L, Geng L, Zhao H, Edelmann W, Somlo S (2002) Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease. Hum Mol Genet 11:1845\u20131854","journal-title":"Hum Mol Genet"},{"key":"16_CR18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1086\/318188","volume":"68","author":"Y Pei","year":"2001","unstructured":"Pei Y, Paterson AD, Wang KR, He N, Hefferton D, Watnick T, Germino GG, Parfrey P, Somlo S, St George-Hyslop P (2001) Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease. Am J Hum Genet 68:355\u2013363","journal-title":"Am J Hum Genet"},{"key":"16_CR19","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1111\/j.1523-1755.2004.66003.x","volume":"66","author":"A Persu","year":"2004","unstructured":"Persu A, Duyme M, Pirson Y, Lens XM, Messiaen T, Breuning MH, Chauveau D, Levy M, Gr\u00fcnfeld J, Devuyst O (2004) Comparison between siblings and twins supports a role for modifier genes in ADPKD. Kidney Int 66:2132\u20132136","journal-title":"Kidney Int"},{"key":"16_CR20","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/ki.1990.330","volume":"38","author":"PA Gabow","year":"1990","unstructured":"Gabow PA, Chapman AB, Johnson AM, Tangel DJ, Duley IT, Kaehny WD, Manco-Johnson M, Schrier RW (1990) Renal structure and hypertension in autosomal dominant polycystic kidney disease. Kidney Int 38:1177\u20131180","journal-title":"Kidney Int"},{"key":"16_CR21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(98)03495-3","volume":"353","author":"N Hateboer","year":"1999","unstructured":"Hateboer N, v Dijk MA, Bogdanova N, Coto E, Saggar-Malik AK, San Millan JL, Torra R, Breuning M, Ravine D (1999) Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group. Lancet 353:103\u2013107","journal-title":"Lancet"},{"key":"16_CR22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1681\/ASN.V1181505","volume":"11","author":"BF King","year":"2000","unstructured":"King BF, Reed JE, Bergstralh EJ, Sheedy PF, Torres VE (2000) Quantification and longitudinal trends of kidney, renal cyst, and renal parenchyma volumes in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 11:1505\u20131511","journal-title":"J Am Soc Nephrol"},{"key":"16_CR23","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1053\/ajkd.2002.33379","volume":"39","author":"GM Fick-Brosnahan","year":"2002","unstructured":"Fick-Brosnahan GM, Belz MM, McFann KK, Johnson AM, Schrier RW (2002) Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study. Am J Kidney Dis 39:1127\u20131134","journal-title":"Am J Kidney Dis"},{"key":"16_CR24","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/ki.1978.75","volume":"13","author":"L Baert","year":"1978","unstructured":"Baert L (1978) Hereditary polycystic kidney disease (adult form): a microdissection study of two cases at an early stage of the disease. Kidney Int 13:519\u2013525","journal-title":"Kidney Int"},{"key":"16_CR25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1067\/mlc.2003.13","volume":"141","author":"M Sutters","year":"2003","unstructured":"Sutters M, Germino GG (2003) Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology. J Lab Clin Med 141:91\u2013101","journal-title":"J Lab Clin Med"},{"key":"16_CR26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ng0792-235","volume":"1","author":"ST Reeders","year":"1992","unstructured":"Reeders ST (1992) Multilocus polycystic disease. Nat Genet 1:235\u2013237","journal-title":"Nat Genet"},{"key":"16_CR27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1471-4914(01)01953-0","volume":"7","author":"Y Pei","year":"2001","unstructured":"Pei Y (2001) A two-hit model of cystogenesis in autosomal dominant polycystic kidney disease? Trends Mol Med 7:151\u2013156","journal-title":"Trends Mol Med"},{"key":"16_CR28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)81793-6","volume":"87","author":"F Qian","year":"1996","unstructured":"Qian F, Watnick TJ, Onuchic LF, Germino GG (1996) The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell 87: 979\u2013987","journal-title":"Cell"},{"key":"16_CR29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI119147","volume":"99","author":"JL Brasier","year":"1997","unstructured":"Brasier JL, Henske EP (1997) Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis. J Clin Invest 99:194\u2013199","journal-title":"J Clin Invest"},{"key":"16_CR30","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1681\/ASN.2005090979","volume":"17","author":"AR Gallagher","year":"2006","unstructured":"Gallagher AR, Hoffmann S, Brown N, Cedzich A, Meruvu S, Podlich D, Feng Y, K\u00f6necke V, Vries U, Hammes H, Gretz N, Witzgall R (2006) A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats. J Am Soc Nephrol 17:2719\u20132730","journal-title":"J Am Soc Nephrol"},{"key":"16_CR31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1053\/j.ackd.2009.12.002","volume":"17","author":"Y Pei","year":"2010","unstructured":"Pei Y, Watnick T (2010) Autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis 17:115\u2013117","journal-title":"Adv Chronic Kidney Dis"},{"key":"16_CR32","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nm1675","volume":"13","author":"K Piontek","year":"2007","unstructured":"Piontek K, Menezes LF, Garcia-Gonzalez MA, Huso DL, Germino GG (2007) A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 13:1490\u20131495","journal-title":"Nat Med"},{"key":"16_CR33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1053\/j.ackd.2010.01.002","volume":"17","author":"AR Gallagher","year":"2010","unstructured":"Gallagher AR, Germino GG, Somlo S (2010) Molecular advances in autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis 17:118\u2013130","journal-title":"Adv Chronic Kidney Dis"},{"key":"16_CR34","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.amjhyper.2004.06.020","volume":"17","author":"CL Kelleher","year":"2004","unstructured":"Kelleher CL, McFann KK, Johnson AM, Schrier RW (2004) Characteristics of hypertension in young adults with autosomal dominant polycystic kidney disease compared with the general U.S. population. Am J Hypertens 17:1029\u20131034","journal-title":"Am J Hypertens"},{"key":"16_CR35","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM198810063191404","volume":"319","author":"KF Hossack","year":"1988","unstructured":"Hossack KF, Leddy CL, Johnson AM, Schrier RW, Gabow PA (1988) Echocardiographic findings in autosomal dominant polycystic kidney disease. N Engl J Med 319:907\u2013912","journal-title":"N Engl J Med"},{"key":"16_CR36","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/ajkd.2001.29216","volume":"38","author":"A Lumiaho","year":"2001","unstructured":"Lumiaho A, Ik\u00e4heimo R, Miettinen R, Niemitukia L, Laitinen T, Rantala A, Lampainen E, Laakso M, Hartikainen J (2001) Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1. Am J Kidney Dis 38:1208\u20131216","journal-title":"Am J Kidney Dis"},{"key":"16_CR37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1681\/ASN.V95837","volume":"9","author":"H Hadimeri","year":"1998","unstructured":"Hadimeri H, Lamm C, Nyberg G (1998) Coronary aneurysms in patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol 9:837\u2013841","journal-title":"J Am Soc Nephrol"},{"key":"16_CR38","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3171\/jns.1995.83.6.1004","volume":"83","author":"WI Schievink","year":"1995","unstructured":"Schievink WI, Huston J, Torres VE, Marsh WR (1995) Intracranial cysts in autosomal dominant polycystic kidney disease. J Neurosurg 83:1004\u20131007","journal-title":"J Neurosurg"},{"key":"16_CR39","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jocn.2004.09.025","volume":"12","author":"GKK Leung","year":"2005","unstructured":"Leung GKK, Fan YW (2005) Chronic subdural haematoma and arachnoid cyst in autosomal dominant polycystic kidney disease (ADPKD). J Clin Neurosci 12:817\u2013819","journal-title":"J Clin Neurosci"},{"key":"16_CR40","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1046\/j.1523-1755.2001.00985.x","volume":"60","author":"ZH Bajwa","year":"2001","unstructured":"Bajwa ZH, Gupta S, Warfield CA, Steinman TI (2001) Pain management in polycystic kidney disease. Kidney Int 60:1631\u20131644","journal-title":"Kidney Int"},{"key":"16_CR41","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/j.1523-1755.2004.00921.x","volume":"66","author":"ZH Bajwa","year":"2004","unstructured":"Bajwa ZH, Sial KA, Malik AB, Steinman TI (2004) Pain patterns in patients with polycystic kidney disease. Kidney Int 66:1561\u20131569","journal-title":"Kidney Int"},{"key":"16_CR42","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0888-7543(95)80020-M","volume":"25","author":"MC Daoust","year":"1995","unstructured":"Daoust MC, Reynolds DM, Bichet DG, Somlo S (1995) Evidence for a third genetic locus for autosomal dominant polycystic kidney disease. Genomics 25:733\u2013736","journal-title":"Genomics"},{"key":"16_CR43","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/BF00209481","volume":"95","author":"N Bogdanova","year":"1995","unstructured":"Bogdanova N, Dworniczak B, Dragova D, Todorov V, Dimitrakov D, Kalinov K, Hallmayer J, Horst J, Kalaydjieva L (1995) Genetic heterogeneity of polycystic kidney disease in Bulgaria. Hum Genet 95:645\u2013650","journal-title":"Hum Genet"},{"key":"16_CR44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00424-005-1469-4","volume":"451","author":"F Qian","year":"2005","unstructured":"Qian F, Noben-Trauth K (2005) Cellular and molecular function of mucolipins (TRPML) and polycystin 2 (TRPP2). Pflugers Arch 451:277\u2013285","journal-title":"Pflugers Arch"},{"key":"16_CR45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng0697-179","volume":"16","author":"F Qian","year":"1997","unstructured":"Qian F, Germino FJ, Cai Y, Zhang X, Somlo S, Germino GG (1997) PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat Genet 16:179\u2013183","journal-title":"Nat Genet"},{"key":"16_CR46","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.94.13.6965","volume":"94","author":"L Tsiokas","year":"1997","unstructured":"Tsiokas L, Kim E, Arnould T, Sukhatme VP, Walz G (1997) Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc Natl Acad Sci USA 94:6965\u20136970","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR47","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","volume":"60","author":"PC Harris","year":"2009","unstructured":"Harris PC, Torres VE (2009) Polycystic kidney disease. Annu Rev Med 60:321\u2013337","journal-title":"Annu Rev Med"},{"key":"16_CR48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cell.2009.03.023","volume":"137","author":"JM Gerdes","year":"2009","unstructured":"Gerdes JM, Davis EE, Katsanis N (2009) The vertebrate primary cilium in development, homeostasis, and disease. Cell 137:32\u201345","journal-title":"Cell"},{"key":"16_CR49","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1681\/ASN.2008050456","volume":"20","author":"F Hildebrandt","year":"2009","unstructured":"Hildebrandt F, Attanasio M, Otto E (2009) Nephronophthisis:disease mechanisms of a ciliopathy. J Am Soc Nephrol 20:23\u201335","journal-title":"J Am Soc Nephrol"},{"key":"16_CR50","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/jcs.050377","volume":"123","author":"P Satir","year":"2010","unstructured":"Satir P, Pedersen LB, Christensen ST (2010) The primary cilium at a glance. J Cell Sci 123:499\u2013503","journal-title":"J Cell Sci"},{"key":"16_CR51","first-page":"314","volume":"107","author":"BK Yoder","year":"1995","unstructured":"Yoder BK, Richards WG, Sweeney WE, Wilkinson JE, Avener ED, Woychik RP (1995) Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease. Proc Assoc Am Physicians 107:314\u2013323","journal-title":"Proc Assoc Am Physicians"},{"key":"16_CR52","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","volume":"151","author":"GJ Pazour","year":"2000","unstructured":"Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG (2000) Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 151:709\u2013718","journal-title":"J Cell Biol"},{"key":"16_CR53","doi-asserted-by":"crossref","first-page":"F978","DOI":"10.1152\/ajprenal.00260.2004","volume":"289","author":"W Liu","year":"2005","unstructured":"Liu W, Murcia NS, Duan Y, Weinbaum S, Yoder BK, Schwiebert E, Satlin LM (2005) Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice. Am J Physiol Renal Physiol 289:F978\u2013F988","journal-title":"Am J Physiol Renal Physiol"},{"key":"16_CR54","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000163955","volume":"63","author":"DN Wheatley","year":"1995","unstructured":"Wheatley DN (1995) Primary cilia in normal and pathological tissues. Pathobiology 63:222\u2013238","journal-title":"Pathobiology"},{"key":"16_CR55","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00232-001-0075-4","volume":"184","author":"HA Praetorius","year":"2001","unstructured":"Praetorius HA, Spring KR (2001) Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 184:71\u201379","journal-title":"J Membr Biol"},{"key":"16_CR56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00232-002-1042-4","volume":"191","author":"HA Praetorius","year":"2003","unstructured":"Praetorius HA, Spring KR (2003) Removal of the MDCK cell primary cilium abolishes flow sensing. J Membr Biol 191:69\u201376","journal-title":"J Membr Biol"},{"key":"16_CR57","unstructured":"Inglis PN, Ou G, Leroux MR, Scholey JM (2007) The sensory cilia of Caenorhabditis elegans. WormBook 1\u201322"},{"key":"16_CR58","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/chemse\/bjp020","volume":"34","author":"PM Jenkins","year":"2009","unstructured":"Jenkins PM, McEwen DP, Martens JR (2009) Olfactory cilia: linking sensory cilia function and human disease. Chem Senses 34:451\u2013464","journal-title":"Chem Senses"},{"key":"16_CR59","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.physiol.67.040403.101353","volume":"67","author":"HA Praetorius","year":"2005","unstructured":"Praetorius HA, Spring KR (2005) A physiological view of the primary cilium. Annu Rev Physiol 67:515\u2013529","journal-title":"Annu Rev Physiol"},{"key":"16_CR60","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1242\/dev.127.11.2347","volume":"127","author":"NS Murcia","year":"2000","unstructured":"Murcia NS, Richards WG, Yoder BK, Mucenski ML, Dunlap JR, Woychik RP (2000) The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development 127:2347\u20132355","journal-title":"Development"},{"key":"16_CR61","doi-asserted-by":"crossref","first-page":"R378","DOI":"10.1016\/S0960-9822(02)00877-1","volume":"12","author":"GJ Pazour","year":"2002","unstructured":"Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB (2002) Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol 12:R378\u2013R380","journal-title":"Curr Biol"},{"key":"16_CR62","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/01.ASN.0000029587.47950.25","volume":"13","author":"BK Yoder","year":"2002","unstructured":"Yoder BK, Hou X, Guay-Woodford LM (2002) The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 13:2508\u20132516","journal-title":"J Am Soc Nephrol"},{"key":"16_CR63","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.physiol.70.113006.100621","volume":"71","author":"J Zhou","year":"2009","unstructured":"Zhou J (2009) Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol 71:83\u2013113","journal-title":"Annu Rev Physiol"},{"key":"16_CR64","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","volume":"33","author":"SM Nauli","year":"2003","unstructured":"Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AEH, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33:129\u2013137","journal-title":"Nat Genet"},{"key":"16_CR65","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.200805124","volume":"182","author":"M K\u00f6ttgen","year":"2008","unstructured":"K\u00f6ttgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, Walz G (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182:437\u2013447","journal-title":"J Cell Biol"},{"key":"16_CR66","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1681\/ASN.2008060564","volume":"20","author":"MC Hogan","year":"2009","unstructured":"Hogan MC, Manganelli L, Woollard JR, Masyuk AI, Masyuk TV, Tammachote R, Huang BQ, Leontovich AA, Beito TG, Madden BJ, Charlesworth MC, Torres VE, LaRusso NF, Harris PC, Ward CJ (2009) Characterization of PKD protein-positive exosome-like vesicles. J Am Soc Nephrol 20:278\u2013288","journal-title":"J Am Soc Nephrol"},{"key":"16_CR67","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg2774","volume":"11","author":"SC Goetz","year":"2010","unstructured":"Goetz SC, Anderson KV (2010) The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 11:331\u2013344","journal-title":"Nat Rev Genet"},{"key":"16_CR68","doi-asserted-by":"crossref","first-page":"11558","DOI":"10.1073\/pnas.0903684106","volume":"106","author":"Y Yu","year":"2009","unstructured":"Yu Y, Ulbrich MH, Li M, Buraei Z, Chen X, Ong ACM, Tong L, Isacoff EY, Yang J (2009) Structural and molecular basis of the assembly of the TRPP2\/PKD1 complex. Proc Natl Acad Sci USA 106:11558\u201311563","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR69","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/emboj.2010.18","volume":"29","author":"A Giamarchi","year":"2010","unstructured":"Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honor\u00e9 E, Williamson MP, Obara T, Ong ACM, Delmas P (2010) A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J 29:1176\u20131191","journal-title":"EMBO J"},{"key":"16_CR70","doi-asserted-by":"crossref","first-page":"9176","DOI":"10.1073\/pnas.0912295107","volume":"107","author":"ET Petri","year":"2010","unstructured":"Petri ET, Celic A, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME (2010) Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Proc Natl Acad Sci USA 107:9176\u20139181","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR71","doi-asserted-by":"crossref","first-page":"F1012","DOI":"10.1152\/ajprenal.00181.2003","volume":"286","author":"HF Cantiello","year":"2004","unstructured":"Cantiello HF (2004) Regulation of calcium signaling by polycystin-2. Am J Physiol Renal Physiol 286:F1012\u2013F1029","journal-title":"Am J Physiol Renal Physiol"},{"key":"16_CR72","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.bbrc.2004.08.044","volume":"322","author":"P Delmas","year":"2004","unstructured":"Delmas P, Padilla F, Osorio N, Coste B, Raoux M, Crest M (2004) Polycystins, calcium signaling, and human diseases. Biochem Biophys Res Commun 322:1374\u20131383","journal-title":"Biochem Biophys Res Commun"},{"key":"16_CR73","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1006\/geno.1998.5618","volume":"54","author":"G Wu","year":"1998","unstructured":"Wu G, Hayashi T, Park JH, Dixit M, Reynolds DM, Li L, Maeda Y, Cai Y, Coca-Prados M, Somlo S (1998) Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25. Genomics 54:564\u2013568","journal-title":"Genomics"},{"key":"16_CR74","doi-asserted-by":"crossref","first-page":"25967","DOI":"10.1074\/jbc.273.40.25967","volume":"273","author":"H Nomura","year":"1998","unstructured":"Nomura H, Turco AE, Pei Y, Kalaydjieva L, Schiavello T, Weremowicz S, Ji W, Morton CC, Meisler M, Reeders ST, Zhou J (1998) Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. J Biol Chem 273:25967\u201325973","journal-title":"J Biol Chem"},{"key":"16_CR75","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/sj.ejhg.5200383","volume":"7","author":"B Veldhuisen","year":"1999","unstructured":"Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (1999) Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). Eur J Hum Genet 7:860\u2013872","journal-title":"Eur J Hum Genet"},{"key":"16_CR76","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/geno.2000.6131","volume":"64","author":"L Guo","year":"2000","unstructured":"Guo L, Schreiber TH, Weremowicz S, Morton CC, Lee C, Zhou J (2000) Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics 64:241\u2013251","journal-title":"Genomics"},{"key":"16_CR77","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20041710","volume":"387","author":"CP Palmer","year":"2005","unstructured":"Palmer CP, Aydar E, Djamgoz MBA (2005) A microbial TRP-like polycystic-kidney-disease-related ion channel gene. Biochem J 387:211\u2013219","journal-title":"Biochem J"},{"key":"16_CR78","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1096\/fj.03-0319fje","volume":"18","author":"P Delmas","year":"2004","unstructured":"Delmas P, Nauli SM, Li X, Coste B, Osorio N, Crest M, Brown DA, Zhou J (2004) Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J 18:740\u2013742","journal-title":"FASEB J"},{"key":"16_CR79","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/35050128","volume":"408","author":"K Hanaoka","year":"2000","unstructured":"Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG (2000) Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 408:990\u2013994","journal-title":"Nature"},{"key":"16_CR80","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbadis.2007.01.003","volume":"1772","author":"M K\u00f6ttgen","year":"2007","unstructured":"K\u00f6ttgen M (2007) TRPP2 and autosomal dominant polycystic kidney disease. Biochim Biophys Acta 1772:836\u2013850","journal-title":"Biochim Biophys Acta"},{"key":"16_CR81","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ng0695-151","volume":"10","author":"J Hughes","year":"1995","unstructured":"Hughes J, Ward CJ, Peral B, Aspinwall R, Clark K, San Mill\u00e1n JL, Gamble V, Harris PC (1995) The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat Genet 10:151\u2013160","journal-title":"Nat Genet"},{"key":"16_CR82","doi-asserted-by":"crossref","first-page":"13035","DOI":"10.1021\/bi035074c","volume":"42","author":"N Nims","year":"2003","unstructured":"Nims N, Vassmer D, Maser RL (2003) Transmembrane domain analysis of polycystin-1, the product of the polycystic kidney disease-1 (PKD1) gene: evidence for 11 membrane-spanning domains. Biochemistry 42:13035\u201313048","journal-title":"Biochemistry"},{"key":"16_CR83","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0888-7543(03)00048-X","volume":"81","author":"A Li","year":"2003","unstructured":"Li A, Tian X, Sung S, Somlo S (2003) Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. Genomics 81:596\u2013608","journal-title":"Genomics"},{"key":"16_CR84","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.133.4.809","volume":"133","author":"GW Moy","year":"1996","unstructured":"Moy GW, Mendoza LM, Schulz JR, Swanson WJ, Glabe CG, Vacquier VD (1996) The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1. J Cell Biol 133:809\u2013817","journal-title":"J Cell Biol"},{"key":"16_CR85","doi-asserted-by":"crossref","first-page":"16981","DOI":"10.1073\/pnas.252484899","volume":"99","author":"F Qian","year":"2002","unstructured":"Qian F, Boletta A, Bhunia AK, Xu H, Liu L, Ahrabi AK, Watnick TJ, Zhou F, Germino GG (2002) Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci USA 99:16981\u201316986","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR86","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1006\/geno.2002.6719","volume":"79","author":"T Yuasa","year":"2002","unstructured":"Yuasa T, Venugopal B, Weremowicz S, Morton CC, Guo L, Zhou J (2002) The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. Genomics 79:376\u2013386","journal-title":"Genomics"},{"key":"16_CR87","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.20755","volume":"209","author":"KA Sutton","year":"2006","unstructured":"Sutton KA, Jungnickel MK, Ward CJ, Harris PC, Florman HM (2006) Functional characterization of PKDREJ, a male germ cell-restricted polycystin. J Cell Physiol 209:493\u2013500","journal-title":"J Cell Physiol"},{"key":"16_CR88","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ygeno.2004.02.008","volume":"84","author":"T Yuasa","year":"2004","unstructured":"Yuasa T, Takakura A, Denker BM, Venugopal B, Zhou J (2004) Polycystin-1L2 is a novel G-protein-binding protein. Genomics 84:126\u2013138","journal-title":"Genomics"},{"key":"16_CR89","first-page":"386","volume":"401","author":"MM Barr","year":"1999","unstructured":"Barr MM, Sternberg PW (1999) A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature 401:386\u2013389","journal-title":"Nature"},{"key":"16_CR90","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1074\/jbc.M109673200","volume":"277","author":"KJ Mengerink","year":"2002","unstructured":"Mengerink KJ, Moy GW, Vacquier VD (2002) suREJ3, a polycystin-1 protein, is cleaved at the GPS domain and localizes to the acrosomal region of sea urchin sperm. J Biol Chem 277:943\u2013948","journal-title":"J Biol Chem"},{"key":"16_CR91","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/mrd.20033","volume":"67","author":"AT Neill","year":"2004","unstructured":"Neill AT, Moy GW, Vacquier VD (2004) Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa. Mol Reprod Dev 67:472\u2013477","journal-title":"Mol Reprod Dev"},{"key":"16_CR92","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cell.2004.07.007","volume":"118","author":"P Delmas","year":"2004","unstructured":"Delmas P (2004) Polycystins: from mechanosensation to gene regulation. Cell 118: 145\u2013148","journal-title":"Cell"},{"key":"16_CR93","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00424-005-1431-5","volume":"451","author":"P Delmas","year":"2005","unstructured":"Delmas P (2005) Polycystins: polymodal receptor\/ion-channel cellular sensors. Pflugers Arch 451:264\u2013276","journal-title":"Pflugers Arch"},{"key":"16_CR94","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.bbrc.2004.08.043","volume":"322","author":"GI Anyatonwu","year":"2004","unstructured":"Anyatonwu GI, Ehrlich BE (2004) Calcium signaling and polycystin-2. Biochem Biophys Res Commun 322:1364\u20131373","journal-title":"Biochem Biophys Res Commun"},{"key":"16_CR95","first-page":"257","volume":"29","author":"S Somlo","year":"1999","unstructured":"Somlo S (1999) The PKD2 gene: structure, interactions, mutations, and inactivation. Adv Nephrol Necker Hosp 29:257\u2013275","journal-title":"Adv Nephrol Necker Hosp"},{"key":"16_CR96","doi-asserted-by":"crossref","first-page":"R356","DOI":"10.1016\/S0960-9822(01)00193-2","volume":"11","author":"S Somlo","year":"2001","unstructured":"Somlo S, Ehrlich B (2001) Human disease: calcium signaling in polycystic kidney disease. Curr Biol 11:R356\u2013R360","journal-title":"Curr Biol"},{"key":"16_CR97","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.embor.7400745","volume":"7","author":"A Giamarchi","year":"2006","unstructured":"Giamarchi A, Padilla F, Coste B, Raoux M, Crest M, Honor\u00e9 E, Delmas P (2006) The versatile nature of the calcium-permeable cation channel TRPP2. EMBO Rep 7:787\u2013793","journal-title":"EMBO Rep"},{"key":"16_CR98","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/stke.2952005re8","volume":"2005","author":"B Nilius","year":"2005","unstructured":"Nilius B, Voets T, Peters J (2005) TRP channels in disease. Sci STKE 2005:re8","journal-title":"Sci STKE"},{"key":"16_CR99","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s00210-005-1027-9","volume":"371","author":"R Witzgall","year":"2005","unstructured":"Witzgall R (2005) Polycystin-2 \u2013 an intracellular or plasma membrane channel? Naunyn Schmiedebergs Arch Pharmacol 371:342\u2013347","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"16_CR100","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00424-005-1417-3","volume":"451","author":"M K\u00f6ttgen","year":"2005","unstructured":"K\u00f6ttgen M, Walz G (2005) Subcellular localization and trafficking of polycystins. Pflugers Arch 451:286\u2013293","journal-title":"Pflugers Arch"},{"key":"16_CR101","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrneph.2009.100","volume":"5","author":"TE Woudenberg-Vrenken","year":"2009","unstructured":"Woudenberg-Vrenken TE, Bindels RJM, Hoenderop JGJ (2009) The role of transient receptor potential channels in kidney disease. Nat Rev Nephrol 5:441\u2013449","journal-title":"Nat Rev Nephrol"},{"key":"16_CR102","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.90277.2008","volume":"297","author":"L Tsiokas","year":"2009","unstructured":"Tsiokas L (2009) Function and regulation of TRPP2 at the plasma membrane. Am J Physiol Renal Physiol 297:F1\u2013F9","journal-title":"Am J Physiol Renal Physiol"},{"key":"16_CR103","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","volume":"369","author":"VE Torres","year":"2007","unstructured":"Torres VE, Harris PC, Pirson Y (2007) Autosomal dominant polycystic kidney disease. Lancet 369:1287\u20131301","journal-title":"Lancet"},{"key":"16_CR104","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1242\/dev.046045","volume":"137","author":"U Tran","year":"2010","unstructured":"Tran U, Zakin L, Schweickert A, Agrawal R, D\u00f6ger R, Blum M, De Robertis EM, Wessely O (2010) The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Development 137:1107\u20131116","journal-title":"Development"},{"key":"16_CR105","doi-asserted-by":"crossref","first-page":"28557","DOI":"10.1074\/jbc.274.40.28557","volume":"274","author":"Y Cai","year":"1999","unstructured":"Cai Y, Maeda Y, Cedzich A, Torres VE, Wu G, Hayashi T, Mochizuki T, Park JH, Witzgall R, Somlo S (1999) Identification and characterization of polycystin-2, the PKD2 gene product. J Biol Chem 274:28557\u201328565","journal-title":"J Biol Chem"},{"key":"16_CR106","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ncb754","volume":"4","author":"P Koulen","year":"2002","unstructured":"Koulen P, Cai Y, Geng L, Maeda Y, Nishimura S, Witzgall R, Ehrlich BE, Somlo S (2002) Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol 4:191\u2013197","journal-title":"Nat Cell Biol"},{"key":"16_CR107","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1681\/ASN.V115814","volume":"11","author":"L Foggensteiner","year":"2000","unstructured":"Foggensteiner L, Bevan AP, Thomas R, Coleman N, Boulter C, Bradley J, Ibraghimov-Beskrovnaya O, Klinger K, Sandford R (2000) Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J Am Soc Nephrol 11:814\u2013827","journal-title":"J Am Soc Nephrol"},{"key":"16_CR108","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1128\/MCB.23.7.2600-2607.2003","volume":"23","author":"Y Luo","year":"2003","unstructured":"Luo Y, Vassilev PM, Li X, Kawanabe Y, Zhou J (2003) Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol 23:2600\u20132607","journal-title":"Mol Cell Biol"},{"key":"16_CR109","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/hmg\/11.1.59","volume":"11","author":"MS Scheffers","year":"2002","unstructured":"Scheffers MS, Le H, van der Bent P, Leonhard W, Prins F, Spruit L, Breuning MH, de Heer E, Peters DJM (2002) Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells. Hum Mol Genet 11:59\u201367","journal-title":"Hum Mol Genet"},{"key":"16_CR110","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.200405023","volume":"166","author":"A Jurczyk","year":"2004","unstructured":"Jurczyk A, Gromley A, Redick S, San Agustin J, Witman G, Pazour GJ, Peters DJM, Doxsey S (2004) Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J Cell Biol 166:637\u2013643","journal-title":"J Cell Biol"},{"key":"16_CR111","doi-asserted-by":"crossref","first-page":"29728","DOI":"10.1074\/jbc.M400544200","volume":"279","author":"DR Rundle","year":"2004","unstructured":"Rundle DR, Gorbsky G, Tsiokas L (2004) PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. J Biol Chem 279:29728\u201329739","journal-title":"J Biol Chem"},{"key":"16_CR112","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1053\/ajkd.2001.29282","volume":"38","author":"A Boletta","year":"2001","unstructured":"Boletta A, Qian F, Onuchic LF, Bragonzi A, Cortese M, Deen PM, Courtoy PJ, Soria MR, Devuyst O, Monaco L, Germino GG (2001) Biochemical characterization of bona fide polycystin-1 in vitro and in vivo. Am J Kidney Dis 38:1421\u20131429","journal-title":"Am J Kidney Dis"},{"key":"16_CR113","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/hmg\/6.9.1483","volume":"6","author":"R Sandford","year":"1997","unstructured":"Sandford R, Sgotto B, Aparicio S, Brenner S, Vaudin M, Wilson RK, Chissoe S, Pepin K, Bateman A, Chothia C, Hughes J, Harris P (1997) Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. Hum Mol Genet 6:1483\u20131489","journal-title":"Hum Mol Genet"},{"key":"16_CR114","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/bbrc.1998.9514","volume":"251","author":"SC Parnell","year":"1998","unstructured":"Parnell SC, Magenheimer BS, Maser RL, Rankin CA, Smine A, Okamoto T, Calvet JP (1998) The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro. Biochem Biophys Res Commun 251:625\u2013631","journal-title":"Biochem Biophys Res Commun"},{"key":"16_CR115","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1172\/JCI119090","volume":"98","author":"L Geng","year":"1996","unstructured":"Geng L, Segal Y, Peissel B, Deng N, Pei Y, Carone F, Rennke HG, Gl\u00fccksmann-Kuis AM, Schneider MC, Ericsson M, Reeders ST, Zhou J (1996) Identification and localization of polycystin, the PKD1 gene product. J Clin Invest 98:2674\u20132682","journal-title":"J Clin Invest"},{"key":"16_CR116","first-page":"F451","volume":"272","author":"L Geng","year":"1997","unstructured":"Geng L, Segal Y, Pavlova A, Barros EJ, L\u00f6hning C, Lu W, Nigam SK, Frischauf AM, Reeders ST, Zhou J (1997) Distribution and developmentally regulated expression of murine polycystin. Am J Physiol 272:F451\u2013F459","journal-title":"Am J Physiol"},{"key":"16_CR117","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1172\/JCI5111","volume":"104","author":"Y Huan","year":"1999","unstructured":"Huan Y, van Adelsberg J (1999) Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J Clin Invest 104:1459\u20131468","journal-title":"J Clin Invest"},{"key":"16_CR118","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/hmg\/9.18.2743","volume":"9","author":"MS Scheffers","year":"2000","unstructured":"Scheffers MS, van der Bent P, Prins F, Spruit L, Breuning MH, Litvinov SV, de Heer E, Peters DJ (2000) Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells. Hum Mol Genet 9:2743\u20132750","journal-title":"Hum Mol Genet"},{"key":"16_CR119","doi-asserted-by":"crossref","first-page":"36786","DOI":"10.1074\/jbc.M306536200","volume":"278","author":"DH Grimm","year":"2003","unstructured":"Grimm DH, Cai Y, Chauvet V, Rajendran V, Zeltner R, Geng L, Avner ED, Sweeney W, Somlo S, Caplan MJ (2003) Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. J Biol Chem 278:36786\u201336793","journal-title":"J Biol Chem"},{"key":"16_CR120","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1128\/MCB.25.18.8285-8298.2005","volume":"25","author":"R Ma","year":"2005","unstructured":"Ma R, Li W, Rundle D, Kong J, Akbarali HI, Tsiokas L (2005) PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol Cell Biol 25:8285\u20138298","journal-title":"Mol Cell Biol"},{"key":"16_CR121","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/emboj.2008.70","volume":"27","author":"C Bai","year":"2008","unstructured":"Bai C, Kim S, Li W, Streets AJ, Ong ACM, Tsiokas L (2008) Activation of TRPP2 through mDia1-dependent voltage gating. EMBO J 27:1345\u20131356","journal-title":"EMBO J"},{"key":"16_CR122","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1681\/ASN.2005050534","volume":"17","author":"M Boca","year":"2006","unstructured":"Boca M, Distefano G, Qian F, Bhunia AK, Germino GG, Boletta A (2006) Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase\/Akt signaling pathway. J Am Soc Nephrol 17:637\u2013647","journal-title":"J Am Soc Nephrol"},{"key":"16_CR123","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/hmg\/ddg190","volume":"12","author":"Q Qian","year":"2003","unstructured":"Qian Q, Hunter LW, Li M, Marin-Padilla M, Prakash YS, Somlo S, Harris PC, Torres VE, Sieck GC (2003) Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells. Hum Mol Genet 12:1875\u20131880","journal-title":"Hum Mol Genet"},{"key":"16_CR124","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1365-2184.2008.00529.x","volume":"41","author":"G Aguiari","year":"2008","unstructured":"Aguiari G, Trimi V, Bogo M, Mangolini A, Szabadkai G, Pinton P, Witzgall R, Harris PC, Borea PA, Rizzuto R, del Senno L (2008) Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells. Cell Prolif 41:554\u2013573","journal-title":"Cell Prolif"},{"key":"16_CR125","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1073\/pnas.97.8.4017","volume":"97","author":"AR Gallagher","year":"2000","unstructured":"Gallagher AR, Cedzich A, Gretz N, Somlo S, Witzgall R (2000) The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proc Natl Acad Sci USA 97:4017\u20134022","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR126","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0022-2836(02)01333-5","volume":"325","author":"Q Li","year":"2003","unstructured":"Li Q, Dai Y, Guo L, Liu Y, Hao C, Wu G, Basora N, Michalak M, Chen XZ (2003) Polycystin-2 associates with tropomyosin-1, an actin microfilament component. J Mol Biol 325:949\u2013962","journal-title":"J Mol Biol"},{"key":"16_CR127","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1093\/hmg\/ddi167","volume":"14","author":"Q Li","year":"2005","unstructured":"Li Q, Montalbetti N, Shen PY, Dai X, Cheeseman CI, Karpinski E, Wu G, Cantiello HF, Chen X (2005) Alpha-actinin associates with polycystin-2 and regulates its channel activity. Hum Mol Genet 14:1587\u20131603","journal-title":"Hum Mol Genet"},{"key":"16_CR128","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.jmb.2007.03.070","volume":"369","author":"A Markoff","year":"2007","unstructured":"Markoff A, Bogdanova N, Knop M, R\u00fcffer C, Kenis H, Lux P, Reutelingsperger C, Todorov V, Dworniczak B, Horst J, Gerke V (2007) Annexin A5 interacts with polycystin-1 and interferes with the polycystin-1 stimulated recruitment of E-cadherin into adherens junctions. J Mol Biol 369:954\u2013966","journal-title":"J Mol Biol"},{"key":"16_CR129","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1111\/j.1742-4658.2008.06616.x","volume":"275","author":"X Chen","year":"2008","unstructured":"Chen X, Li Q, Wu Y, Liang G, Lara CJ, Cantiello HF (2008) Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton. FEBS J 275:4675\u20134683","journal-title":"FEBS J"},{"key":"16_CR130","doi-asserted-by":"crossref","first-page":"32888","DOI":"10.1074\/jbc.M006624200","volume":"275","author":"S Lehtonen","year":"2000","unstructured":"Lehtonen S, Ora A, Olkkonen VM, Geng L, Zerial M, Somlo S, Lehtonen E (2000) In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. J Biol Chem 275:32888\u201332893","journal-title":"J Biol Chem"},{"key":"16_CR131","doi-asserted-by":"crossref","first-page":"35009","DOI":"10.1074\/jbc.M314206200","volume":"279","author":"S Hidaka","year":"2004","unstructured":"Hidaka S, K\u00f6necke V, Osten L, Witzgall R (2004) PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. J Biol Chem 279:35009\u201335016","journal-title":"J Biol Chem"},{"key":"16_CR132","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/sj.emboj.7600566","volume":"24","author":"M K\u00f6ttgen","year":"2005","unstructured":"K\u00f6ttgen M, Benzing T, Simmen T, Tauber R, Buchholz B, Feliciangeli S, Huber TB, Schermer B, Kramer-Zucker A, H\u00f6pker K, Simmen KC, Tschucke CC, Sandford R, Kim E, Thomas G, Walz G (2005) Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. 24:705\u2013716","journal-title":"EMBO J."},{"key":"16_CR133","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1073\/pnas.96.7.3934","volume":"96","author":"L Tsiokas","year":"1999","unstructured":"Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP (1999) Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci USA 96:3934\u20133939","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR134","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/embor.2008.29","volume":"9","author":"C Bai","year":"2008","unstructured":"Bai C, Giamarchi A, Rodat-Despoix L, Padilla F, Downs T, Tsiokas L, Delmas P (2008) Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep 9:472\u2013479","journal-title":"EMBO Rep"},{"key":"16_CR135","doi-asserted-by":"crossref","first-page":"35507","DOI":"10.1074\/jbc.M109.060228","volume":"284","author":"T Kobori","year":"2009","unstructured":"Kobori T, Smith GD, Sandford R, Edwardson JM (2009) The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement. J Biol Chem 284:35507\u201335513","journal-title":"J Biol Chem"},{"key":"16_CR136","doi-asserted-by":"crossref","first-page":"36431","DOI":"10.1074\/jbc.M109.068916","volume":"284","author":"Y Li","year":"2009","unstructured":"Li Y, Santoso NG, Yu S, Woodward OM, Qian F, Guggino WB (2009) Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease. J Biol Chem 284:36431\u201336441","journal-title":"J Biol Chem"},{"key":"16_CR137","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2009.08.045","volume":"139","author":"R Sharif-Naeini","year":"2009","unstructured":"Sharif-Naeini R, Folgering JHA, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJM, Honor\u00e9 E (2009) Polycystin-1 and -2 dosage regulates pressure sensing. Cell 139:587\u2013596","journal-title":"Cell"},{"key":"16_CR138","doi-asserted-by":"crossref","first-page":"18794","DOI":"10.1074\/jbc.M109.090662","volume":"285","author":"E Sammels","year":"2010","unstructured":"Sammels E, Devogelaere B, Mekahli D, Bultynck G, Missiaen L, Parys JB, Cai Y, Somlo S, Smedt H de (2010) Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain. J Biol Chem 285:18794\u201318805","journal-title":"J Biol Chem"},{"key":"16_CR139","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/hmg\/ddp463","volume":"19","author":"H Gao","year":"2010","unstructured":"Gao H, Wang Y, Wegierski T, Skouloudaki K, P\u00fctz M, Fu X, Engel C, Boehlke C, Peng H, Kuehn EW, Kim E, Kramer-Zucker A, Walz G (2010) PRKCSH\/80\u00a0K-H, the protein mutated in polycystic liver disease, protects polycystin-2\/TRPP2 against HERP-mediated degradation. Hum Mol Genet 19:16\u201324","journal-title":"Hum Mol Genet"},{"key":"16_CR140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(02)00716-X","volume":"109","author":"AK Bhunia","year":"2002","unstructured":"Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109:157\u2013168","journal-title":"Cell"},{"key":"16_CR141","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","volume":"103","author":"JM Shillingford","year":"2006","unstructured":"Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T (2006) The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci USA 103:5466\u20135471","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR142","doi-asserted-by":"crossref","first-page":"e9239","DOI":"10.1371\/journal.pone.0009239","volume":"5","author":"R Dere","year":"2010","unstructured":"Dere R, Wilson PD, Sandford RN, Walker CL (2010) Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR. PLoS One 5:e9239","journal-title":"PLoS One"},{"key":"16_CR143","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1681\/ASN.2009040421","volume":"21","author":"JM Shillingford","year":"2010","unstructured":"Shillingford JM, Piontek KB, Germino GG, Weimbs T (2010) Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1. J Am Soc Nephrol 21:489\u2013497","journal-title":"J Am Soc Nephrol"},{"key":"16_CR144","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1074\/jbc.274.8.4947","volume":"274","author":"E Kim","year":"1999","unstructured":"Kim E, Arnould T, Sellin LK, Benzing T, Fan MJ, Gr\u00fcning W, Sokol SY, Drummond I, Walz G (1999) The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem 274:4947\u20134953","journal-title":"J Biol Chem"},{"key":"16_CR145","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1093\/hmg\/ddn208","volume":"17","author":"M Lal","year":"2008","unstructured":"Lal M, Song X, Pluznick JL, Di Giovanni V, Merrick DM, Rosenblum ND, Chauvet V, Gottardi CJ, Pei Y, Caplan MJ (2008) Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet 17:3105\u20133117","journal-title":"Hum Mol Genet"},{"key":"16_CR146","doi-asserted-by":"crossref","first-page":"55455","DOI":"10.1074\/jbc.M402905200","volume":"279","author":"S Puri","year":"2004","unstructured":"Puri S, Magenheimer BS, Maser RL, Ryan EM, Zien CA, Walker DD, Wallace DP, Hempson SJ, Calvet JP (2004) Polycystin-1 activates the calcineurin\/NFAT (nuclear factor of activated T-cells) signaling pathway. J Biol Chem 279:55455\u201355464","journal-title":"J Biol Chem"},{"key":"16_CR147","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ncb1326","volume":"7","author":"X Li","year":"2005","unstructured":"Li X, Luo Y, Starremans PG, McNamara CA, Pei Y, Zhou J (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol 7:1202\u20131212","journal-title":"Nat Cell Biol"},{"key":"16_CR148","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2369-8-12","volume":"8","author":"J Park","year":"2007","unstructured":"Park J, Schutzer WE, Lindsley JN, Bagby SP, Oyama TT, Anderson S, Weiss RH (2007) p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. BMC Nephrol 8:12","journal-title":"BMC Nephrol"},{"key":"16_CR149","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1172\/JCI0212867","volume":"109","author":"C Nickel","year":"2002","unstructured":"Nickel C, Benzing T, Sellin L, Gerke P, Karihaloo A, Liu Z, Cantley LG, Walz G (2002) The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. J Clin Invest 109:481\u2013489","journal-title":"J Clin Invest"},{"key":"16_CR150","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbrc.2006.09.042","volume":"350","author":"M Banzi","year":"2006","unstructured":"Banzi M, Aguiari G, Trimi V, Mangolini A, Pinton P, Witzgall R, Rizzuto R, del Senno L (2006) Polycystin-1 promotes PKCalpha-mediated NF-kappaB activation in kidney cells. Biochem Biophys Res Commun 350:257\u2013262","journal-title":"Biochem Biophys Res Commun"},{"key":"16_CR151","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/emboj.2008.307","volume":"28","author":"T Wegierski","year":"2009","unstructured":"Wegierski T, Steffl D, Kopp C, Tauber R, Buchholz B, Nitschke R, Kuehn EW, Walz G, K\u00f6ttgen M (2009) TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum. EMBO J 28:490\u2013499","journal-title":"EMBO J"},{"key":"16_CR152","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1242\/jcs.02818","volume":"119","author":"L Geng","year":"2006","unstructured":"Geng L, Okuhara D, Yu Z, Tian X, Cai Y, Shibazaki S, Somlo S (2006) Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif. J Cell Sci 119:1383\u20131395","journal-title":"J Cell Sci"},{"key":"16_CR153","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1093\/hmg\/ddl070","volume":"15","author":"AJ Streets","year":"2006","unstructured":"Streets AJ, Moon DJ, Kane ME, Obara T, Ong ACM (2006) Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum Mol Genet 15:1465\u20131473","journal-title":"Hum Mol Genet"},{"key":"16_CR154","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1681\/ASN.2005080830","volume":"17","author":"SM Nauli","year":"2006","unstructured":"Nauli SM, Rossetti S, Kolb RJ, Alenghat FJ, Consugar MB, Harris PC, Ingber DE, Loghman-Adham M, Zhou J (2006) Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol 17:1015\u20131025","journal-title":"J Am Soc Nephrol"},{"key":"16_CR155","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00424-006-0168-0","volume":"453","author":"F Kotsis","year":"2007","unstructured":"Kotsis F, Nitschke R, Boehlke C, Bashkurov M, Walz G, Kuehn EW (2007) Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1). Pflugers Arch 453: 819\u2013829","journal-title":"Pflugers Arch"},{"key":"16_CR156","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1242\/dev.049437","volume":"137","author":"S Xia","year":"2010","unstructured":"Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137:1075\u20131084","journal-title":"Development"},{"key":"16_CR157","doi-asserted-by":"crossref","first-page":"12569","DOI":"10.1073\/pnas.0602702103","volume":"103","author":"Y Ishimaru","year":"2006","unstructured":"Ishimaru Y, Inada H, Kubota M, Zhuang H, Tominaga M, Matsunami H (2006) Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci USA 103:12569\u201312574","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR158","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nature05084","volume":"442","author":"AL Huang","year":"2006","unstructured":"Huang AL, Chen X, Hoon MA, Chandrashekar J, Guo W, Tr\u00e4nkner D, Ryba NJP, Zuker CS (2006) The cells and logic for mammalian sour taste detection. Nature 442:934\u2013938","journal-title":"Nature"},{"key":"16_CR159","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.semcdb.2008.11.010","volume":"20","author":"LN Vandenberg","year":"2009","unstructured":"Vandenberg LN, Levin M (2009) Perspectives and open problems in the early phases of left-right patterning. Semin Cell Dev Biol 20:456\u2013463","journal-title":"Semin Cell Dev Biol"},{"key":"16_CR160","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1074\/jbc.M411496200","volume":"280","author":"M Murakami","year":"2005","unstructured":"Murakami M, Ohba T, Xu F, Shida S, Satoh E, Ono K, Miyoshi I, Watanabe H, Ito H, Iijima T (2005) Genomic organization and functional analysis of murine PKD2L1. J Biol Chem 280:5626\u20135635","journal-title":"J Biol Chem"},{"key":"16_CR161","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1681\/ASN.V132293","volume":"13","author":"N Basora","year":"2002","unstructured":"Basora N, Nomura H, Berger UV, Stayner C, Guo L, Shen X, Zhou J (2002) Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. J Am Soc Nephrol 13:293\u2013301","journal-title":"J Am Soc Nephrol"},{"key":"16_CR162","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0008-6363(02)00858-1","volume":"58","author":"T Volk","year":"2003","unstructured":"Volk T, Schwoerer AP, Thiessen S, Schultz J, Ehmke H (2003) A polycystin-2-like large conductance cation channel in rat left ventricular myocytes. Cardiovasc Res 58:76\u201388","journal-title":"Cardiovasc Res"},{"key":"16_CR163","first-page":"383","volume":"401","author":"XZ Chen","year":"1999","unstructured":"Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J (1999) Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature 401:383\u2013386","journal-title":"Nature"},{"key":"16_CR164","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/geno.1994.1506","volume":"23","author":"SA Keller","year":"1994","unstructured":"Keller SA, Jones JM, Boyle A, Barrow LL, Killen PD, Green DG, Kapousta NV, Hitchcock PF, Swank RT, Meisler MH (1994) Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus. Genomics 23:309\u2013320","journal-title":"Genomics"},{"key":"16_CR165","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/hmg\/4.11.2183","volume":"4","author":"P Sanyanusin","year":"1995","unstructured":"Sanyanusin P, McNoe LA, Sullivan MJ, Weaver RG, Eccles MR (1995) Mutation of PAX2 in two siblings with renal-coloboma syndrome. Hum Mol Genet 4:2183\u20132184","journal-title":"Hum Mol Genet"},{"key":"16_CR166","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1152\/physrev.1996.76.3.719","volume":"76","author":"B Lindemann","year":"1996","unstructured":"Lindemann B (1996) Taste reception. Physiol Rev 76:718\u2013766","journal-title":"Physiol Rev"},{"key":"16_CR167","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00424-007-0247-x","volume":"454","author":"SD Roper","year":"2007","unstructured":"Roper SD (2007) Signal transduction and information processing in mammalian taste buds. Pflugers Arch 454:759\u2013776","journal-title":"Pflugers Arch"},{"key":"16_CR168","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nature08783","volume":"464","author":"J Chandrashekar","year":"2010","unstructured":"Chandrashekar J, Kuhn C, Oka Y, Yarmolinsky DA, Hummler E, Ryba NJP, Zuker CS (2010) The cells and peripheral representation of sodium taste in mice. Nature 464:297\u2013301","journal-title":"Nature"},{"key":"16_CR169","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1471-4159.2006.03842.x","volume":"98","author":"ND LopezJimenez","year":"2006","unstructured":"LopezJimenez ND, Cavenagh MM, Sainz E, Cruz-Ithier MA, Battey JF, Sullivan SL (2006) Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. J Neurochem 98:68\u201377","journal-title":"J Neurochem"},{"key":"16_CR170","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/embor.2008.89","volume":"9","author":"H Inada","year":"2008","unstructured":"Inada H, Kawabata F, Ishimaru Y, Fushiki T, Matsunami H, Tominaga M (2008) Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep 9:690\u2013697","journal-title":"EMBO Rep"},{"key":"16_CR171","doi-asserted-by":"crossref","first-page":"C1005","DOI":"10.1152\/ajpcell.2001.281.3.C1005","volume":"281","author":"V Lyall","year":"2001","unstructured":"Lyall V, Alam RI, Phan DQ, Ereso GL, Phan TH, Malik SA, Montrose MH, Chu S, Heck GL, Feldman GM, DeSimone JA (2001) Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. Am J Physiol Cell Physiol 281:C1005\u2013C1013","journal-title":"Am J Physiol Cell Physiol"},{"key":"16_CR172","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1113\/jphysiol.2002.033811","volume":"547","author":"TA Richter","year":"2003","unstructured":"Richter TA, Caicedo A, Roper SD (2003) Sour taste stimuli evoke Ca2+ and pH responses in mouse taste cells. J Physiol (Lond) 547:475\u2013483","journal-title":"J Physiol (Lond)"},{"key":"16_CR173","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00424-008-0558-6","volume":"457","author":"T Shimizu","year":"2009","unstructured":"Shimizu T, Janssens A, Voets T, Nilius B (2009) Regulation of the murine TRPP3 channel by voltage, pH, and changes in cell volume. Pflugers Arch 457:795\u2013807","journal-title":"Pflugers Arch"},{"key":"16_CR193","doi-asserted-by":"crossref","unstructured":"Nelson TM, Lopez Jimenez ND, Tessarollo L, Inoue M, Bachmanov AA, Sullivan SL (2010) Taste Function in Mice with a Targetted Mutation of the Pkd1l3 Gene. Chemical Senses","DOI":"10.1093\/chemse\/bjq070"},{"key":"16_CR194","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/chemse\/bjq044","volume":"35","author":"CD Dotson","year":"2010","unstructured":"Dotson CD (2010) The search for mechanisms underlying the sour taste evoked by acids continues. Chemical Senses 35:545\u2013547","journal-title":"Chemical Senses"},{"key":"16_CR174","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1111\/j.1471-4159.2007.04940.x","volume":"103","author":"Q Li","year":"2007","unstructured":"Li Q, Dai X, Shen PY, Wu Y, Long W, Chen CX, Hussain Z, Wang S, Chen X (2007) Direct binding of alpha-actinin enhances TRPP3 channel activity. J Neurochem 103:2391\u20132400","journal-title":"J Neurochem"},{"key":"16_CR175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbamem.2006.01.020","volume":"1758","author":"X Dai","year":"2006","unstructured":"Dai X, Karpinski E, Chen X (2006) Permeation and inhibition of polycystin-L channel by monovalent organic cations. Biochim Biophys Acta 1758:197\u2013205","journal-title":"Biochim Biophys Acta"},{"key":"16_CR176","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(02)03071-5","volume":"525","author":"Y Liu","year":"2002","unstructured":"Liu Y, Li Q, Tan M, Zhang Y, Karpinski E, Zhou J, Chen X (2002) Modulation of the human polycystin-L channel by voltage and divalent cations. FEBS Lett 525:71\u201376","journal-title":"FEBS Lett"},{"key":"16_CR177","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1021\/bi034210a","volume":"42","author":"Q Li","year":"2003","unstructured":"Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ (2003) Troponin I binds polycystin-L and inhibits its calcium-induced channel. Biochemistry 42:7618\u20137625","journal-title":"Biochemistry"},{"key":"16_CR178","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00424-005-1458-7","volume":"451","author":"N Montalbetti","year":"2005","unstructured":"Montalbetti N, Li Q, Gonz\u00e1lez-Perrett S, Semprine J, Chen X, Cantiello HF (2005) Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast. Pflugers Arch 451:294\u2013303","journal-title":"Pflugers Arch"},{"key":"16_CR179","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrn2149","volume":"8","author":"AP Christensen","year":"2007","unstructured":"Christensen AP, Corey DP (2007) TRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci 8:510\u2013521","journal-title":"Nat Rev Neurosci"},{"key":"16_CR180","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1248\/bpb.31.1496","volume":"31","author":"Y Chen","year":"2008","unstructured":"Chen Y, Zhang Z, Lv X, Wang Y, Hu Z, Sun H, Tan R, Liu Y, Bian G, Xiao Y, Li Q, Yang Q, Ai J, Feng L, Yang Y, Wei Y, Zhou Q (2008) Expression of Pkd2l2 in testis is implicated in spermatogenesis. Biol Pharm Bull 31:1496\u20131500","journal-title":"Biol Pharm Bull"},{"key":"16_CR181","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1095\/biolreprod.102.005546","volume":"67","author":"RA Taft","year":"2002","unstructured":"Taft RA, Denegre JM, Pendola FL, Eppig JJ (2002) Identification of genes encoding mouse oocyte secretory and transmembrane proteins by a signal sequence trap. Biol Reprod 67:953\u2013960","journal-title":"Biol Reprod"},{"key":"16_CR182","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/dvdy.21454","volume":"237","author":"VL Horner","year":"2008","unstructured":"Horner VL, Wolfner MF (2008) Transitioning from egg to embryo: triggers and mechanisms of egg activation. Dev Dyn 237:527\u2013544","journal-title":"Dev Dyn"},{"key":"16_CR183","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/hmg\/8.3.543","volume":"8","author":"J Hughes","year":"1999","unstructured":"Hughes J, Ward CJ, Aspinwall R, Butler R, Harris PC (1999) Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. Hum Mol Genet 8:543\u2013549","journal-title":"Hum Mol Genet"},{"key":"16_CR184","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/mrd.20410","volume":"73","author":"Y Butscheid","year":"2006","unstructured":"Butscheid Y, Chubanov V, Steger K, Meyer D, Dietrich A, Gudermann T (2006) Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head. Mol Reprod Dev 73:350\u2013360","journal-title":"Mol Reprod Dev"},{"key":"16_CR185","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1071\/BI9510581","volume":"4","author":"CR Austin","year":"1951","unstructured":"Austin CR (1951) Observations on the penetration of the sperm in the mammalian egg. Aust J Sci Res B 4:581\u2013596","journal-title":"Aust J Sci Res B"},{"key":"16_CR186","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/168697b0","volume":"168","author":"MC Chang","year":"1951","unstructured":"Chang MC (1951) Fertilizing capacity of spermatozoa deposited into the fallopian tubes. Nature 168:697\u2013698","journal-title":"Nature"},{"key":"16_CR187","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI41585","volume":"120","author":"M Ikawa","year":"2010","unstructured":"Ikawa M, Inoue N, Benham AM, Okabe M (2010) Fertilization: a sperm\u2019s journey to and interaction with the oocyte. J Clin Invest 120:984\u2013994","journal-title":"J Clin Invest"},{"key":"16_CR188","doi-asserted-by":"crossref","first-page":"8661","DOI":"10.1073\/pnas.0800603105","volume":"105","author":"KA Sutton","year":"2008","unstructured":"Sutton KA, Jungnickel MK, Florman HM (2008) A polycystin-1 controls postcopulatory reproductive selection in mice. Proc Natl Acad Sci USA 105:8661\u20138666","journal-title":"Proc Natl Acad Sci USA"},{"key":"16_CR189","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/0300985809353553","volume":"47","author":"P Vogel","year":"2010","unstructured":"Vogel P, Read R, Hansen GM, Freay LC, Zambrowicz BP, Sands AT (2010) Situs inversus in Dpcd\/Poll\u2013\/\u2013, Nme7\u2013\/\u2013, and Pkd1l1\u2013\/\u2013 mice. Vet Pathol 47:120\u2013131","journal-title":"Vet Pathol"},{"key":"16_CR190","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1432-0436.2005.00048.x","volume":"73","author":"C Karcher","year":"2005","unstructured":"Karcher C, Fischer A, Schweickert A, Bitzer E, Horie S, Witzgall R, Blum M (2005) Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation 73:425\u2013432","journal-title":"Differentiation"},{"key":"16_CR191","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1093\/hmg\/ddp304","volume":"18","author":"FE Mackenzie","year":"2009","unstructured":"Mackenzie FE, Romero R, Williams D, Gillingwater T, Hilton H, Dick J, Riddoch-Contreras J, Wong F, Ireson L, Powles-Glover N, Riley G, Underhill P, Hough T, Arkell R, Greensmith L, Ribchester RR, Blanco G (2009) Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse. Hum Mol Genet 18:3553\u20133566","journal-title":"Hum Mol Genet"},{"key":"16_CR192","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJM198108203050820","volume":"305","author":"W Blom","year":"1981","unstructured":"Blom W, de Muinck Keizer SM, Scholte HR (1981) Acetyl-CoA carboxylase deficiency: an inborn error of de novo fatty acid synthesis. N Engl J Med 305:465\u2013466","journal-title":"N Engl J Med"}],"container-title":["Advances in Experimental Medicine and Biology","Transient Receptor Potential Channels"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-007-0265-3_16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T07:28:00Z","timestamp":1637220480000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-94-007-0265-3_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,24]]},"ISBN":["9789400702646","9789400702653"],"references-count":194,"URL":"https:\/\/doi.org\/10.1007\/978-94-007-0265-3_16","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,24]]}}}