{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:18:08Z","timestamp":1789654688524,"version":"4.0.1"},"publisher-location":"Dordrecht","reference-count":68,"publisher":"Springer Netherlands","isbn-type":[{"value":"9789400709393","type":"print"},{"value":"9789400709409","type":"electronic"}],"license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"DOI":"10.1007\/978-94-007-0940-9_12","type":"book-chapter","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T12:59:48Z","timestamp":1304945988000},"page":"197-211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Nonideal Coiled Coil of M Protein and Its Multifarious Functions in Pathogenesis"],"prefix":"10.1007","author":[{"given":"Partho","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"12_CR1","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.4049\/jimmunol.157.11.4935","volume":"157","author":"P Accardo","year":"1996","unstructured":"Accardo P, S\u00e1nchez-Corral P, Criado O, Garc\u00eda E, Rodriguez de C\u00f3rdoba S (1996) Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding site. J Immunol 157:4935\u20134939","journal-title":"J Immunol"},{"key":"12_CR2","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.4049\/jimmunol.148.10.3238","volume":"148","author":"B \u00c5kerstr\u00f6m","year":"1992","unstructured":"\u00c5kerstr\u00f6m B, Lindahl G, Bj\u00f6rck L, Lindqvist A (1992) Protein Arp and protein H from group A streptococci. Ig binding and dimerization are regulated by temperature. J Immunol 148: 3238\u20133243","journal-title":"J Immunol"},{"key":"12_CR3","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.1021\/bi052455c","volume":"45","author":"I Andr\u00e9","year":"2006","unstructured":"Andr\u00e9 I, Persson J, Blom AM, Nilsson H, Drakenberg T, Lindahl G, Linse S (2006) Streptococcal M protein: structural studies of the hypervariable region, free and bound to human C4BP. Biochemistry 45:4559\u20134568","journal-title":"Biochemistry"},{"key":"12_CR4","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.3201\/eid1410.071660","volume":"14","author":"RK Aziz","year":"2008","unstructured":"Aziz RK, Kotb M (2008) Rise and persistence of global M1T1 clone of Streptococcus pyogenes. Emerg Infect Dis 14:1511\u20131517","journal-title":"Emerg Infect Dis"},{"key":"12_CR5","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1084\/jem.143.4.759","volume":"143","author":"EH Beachey","year":"1976","unstructured":"Beachey EH, Ofek I (1976) Epithelial cell binding of group A streptococci by lipoteichoic acid on fimbriae denuded of M protein. J Exp Med 143:759\u2013771","journal-title":"J Exp Med"},{"key":"12_CR6","doi-asserted-by":"publisher","first-page":"9862","DOI":"10.1074\/jbc.270.17.9862","volume":"270","author":"A Berge","year":"1995","unstructured":"Berge A, Bj\u00f6rck L (1995) Streptococcal cysteine proteinase releases biologically active fragments of streptococcal surface proteins. J Biol Chem 270:9862\u20139867","journal-title":"J Biol Chem"},{"key":"12_CR7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1046\/j.1365-2958.2001.02664.x","volume":"42","author":"K Bergg\u00e5rd","year":"2001","unstructured":"Bergg\u00e5rd K, Johnsson E, Morfeldt E, Persson J, Stalhammar-Carlemalm M, Lindahl G (2001) Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes. Mol Microbiol 42:539\u2013551","journal-title":"Mol Microbiol"},{"key":"12_CR8","doi-asserted-by":"publisher","first-page":"17713","DOI":"10.1073\/pnas.0606741103","volume":"103","author":"W Blankenfeldt","year":"2006","unstructured":"Blankenfeldt W, Thom\u00e4 NH, Wray JS, Gautel M, Schlichting I (2006) Crystal structures of human cardiac \u03b2-myosin II S2-\u0394 provide insight into the functional role of the S2 subfragment. Proc Natl Acad Sci USA 103:17713\u201317717","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR9","doi-asserted-by":"publisher","first-page":"8496","DOI":"10.1073\/pnas.131219198","volume":"98","author":"JH Brown","year":"2001","unstructured":"Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C (2001) Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci USA 98:8496\u20138501","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR10","doi-asserted-by":"publisher","first-page":"18878","DOI":"10.1073\/pnas.0509269102","volume":"102","author":"JH Brown","year":"2005","unstructured":"Brown JH, Zhou Z, Reshetnikova L, Robinson H, Yammani RD, Tobacman LS, Cohen C (2005) Structure of the mid-region of tropomyosin: bending and binding sites for actin. Proc Natl Acad Sci USA 102:18878\u201318883","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR11","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1128\/iai.59.5.1811-1817.1991","volume":"59","author":"MG Caparon","year":"1991","unstructured":"Caparon MG, Stephens DS, Ols\u00e9n A, Scott JR (1991) Role of M protein in adherence of group A streptococci. Infect Immun 59:1811\u20131817","journal-title":"Infect Immun"},{"key":"12_CR12","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1084\/jem.20030543","volume":"198","author":"F Carlsson","year":"2003","unstructured":"Carlsson F, Bergg\u00e5rd K, St\u00e5lhammar-Carlemalm M, Lindahl G (2003) Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein. J Exp Med 198:1057\u20131068","journal-title":"J Exp Med"},{"key":"12_CR13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1365-2958.2005.04527.x","volume":"56","author":"F Carlsson","year":"2005","unstructured":"Carlsson F, Sandin C, Lindahl G (2005) Human fibrinogen bound to Streptococcus pyogenes M protein inhibits complement deposition via the classical pathway. Mol Microbiol 56:28\u201339","journal-title":"Mol Microbiol"},{"key":"12_CR14","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/nature05021","volume":"442","author":"F Carlsson","year":"2006","unstructured":"Carlsson F, St\u00e5lhammar-Carlemalm M, Fl\u00e4rdh K, Sandin C, Carlemalm E, Lindahl G (2006) Signal sequence directs localized secretion of bacterial surface proteins. Nature 442:943\u2013946","journal-title":"Nature"},{"key":"12_CR15","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1365-3083.1995.tb03677.x","volume":"42","author":"T Cedervall","year":"1995","unstructured":"Cedervall T, \u00c5kesson P, Stenberg L, Herrmann A, \u00c5kerstr\u00f6m B (1995) Allosteric and temperature effects on the plasma protein binding by streptococcal M protein family members. Scand J Immunol 42:433\u2013441","journal-title":"Scand J Immunol"},{"key":"12_CR16","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.1021\/bi962971q","volume":"36","author":"T Cedervall","year":"1997","unstructured":"Cedervall T, Johansson MU, \u00c5kerstr\u00f6m B (1997) Coiled-coil structure of group A streptococcal M proteins. Different temperature stability of class A and C proteins by hydrophobic-nonhydrophobic amino acid substitutions at heptad positions a and d. Biochemistry 36: 4987\u20134994","journal-title":"Biochemistry"},{"key":"12_CR17","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1111\/j.1365-2958.2005.04786.x","volume":"57","author":"KH Cho","year":"2005","unstructured":"Cho KH, Caparon MG (2005) Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes. Mol Microbiol 57:1545\u20131556","journal-title":"Mol Microbiol"},{"key":"12_CR18","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1096\/fj.06-5804fje","volume":"20","author":"JN Cole","year":"2006","unstructured":"Cole JN, McArthur JD, McKay FC, Sanderson-Smith ML, Cork AJ, Ranson M, Rohde M, Itzek A, Sun H, Ginsburg D, Kotb M, Nizet V, Chhatwal GS, Walker MJ (2006) Trigger for group A streptococcal M1T1 invasive disease. FASEB J 20:1745\u20131747","journal-title":"FASEB J"},{"key":"12_CR19","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1073\/pnas.050587897","volume":"97","author":"D Cue","year":"2000","unstructured":"Cue D, Southern SO, Southern PJ, Prabhakar J, Lorelli W, Smallheer JM, Mousa SA, Cleary PP (2000) A nonpeptide integrin antagonist can inhibit epithelial cell ingestion of Streptococcus pyogenes by blocking formation of integrin \u03b15\u03b21-fibronectin-M1 protein complexes. Proc Natl Acad Sci USA 97:2858\u20132863","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1128\/CMR.13.3.470-511.2000","volume":"13","author":"MW Cunningham","year":"2000","unstructured":"Cunningham MW (2000) Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 13:470\u2013511","journal-title":"Clin Microbiol Rev"},{"key":"12_CR21","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1073\/pnas.89.4.1320","volume":"89","author":"MW Cunningham","year":"1992","unstructured":"Cunningham MW, Antone SM, Gulizia JM, McManus BM, Fischetti VA, Gauntt CJ (1992) Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin. Proc Natl Acad Sci USA 89:1320\u20131324","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR22","first-page":"833","volume":"12","author":"JB Dale","year":"2005","unstructured":"Dale JB, Penfound T, Chiang EY, Long V, Shulman ST, Beall B (2005) Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes. Clin Diagn Lab Immunol 12:833\u2013836","journal-title":"Clin Diagn Lab Immunol"},{"key":"12_CR23","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1084\/jem.158.5.1727","volume":"158","author":"JB Dale","year":"1983","unstructured":"Dale JB, Seyer JM, Beachey EH (1983) Type-specific immunogenicity of a chemically synthesized peptide fragment of type 5 streptococcal M protein. J Exp Med 158:1727\u20131732","journal-title":"J Exp Med"},{"key":"12_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1086\/324621","volume":"34","author":"RF Facklam","year":"2002","unstructured":"Facklam RF, Martin DR, Lovgren M, Johnson DR, Efstratiou A, Thompson TA, Gowan S, Kriz P, Tyrrell GJ, Kaplan E, Beall B (2002) Extension of the Lancefield classification for group A streptococci by addition of 22 new M protein gene sequence types from clinical isolates: emm103 to emm124. Clin Infect Dis 34:28\u201338","journal-title":"Clin Infect Dis"},{"key":"12_CR25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1128\/CMR.2.3.285","volume":"2","author":"VA Fischetti","year":"1989","unstructured":"Fischetti VA (1989) Streptococcal M protein: molecular design and biological behavior. Clin Microbiol Rev 2:285\u2013314","journal-title":"Clin Microbiol Rev"},{"key":"12_CR26","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.4049\/jimmunol.141.10.3592","volume":"141","author":"VA Fischetti","year":"1988","unstructured":"Fischetti VA, Windels M (1988) Mapping the immunodeterminants of the complete streptococcal M6 protein molecule. Identification of an immunodominant region. J Immunol 141:3592\u20133599","journal-title":"J Immunol"},{"key":"12_CR27","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1046\/j.1365-2958.2000.02084.x","volume":"37","author":"IM Frick","year":"2000","unstructured":"Frick IM, M\u00f6rgelin M, Bj\u00f6rck L (2000) Virulent aggregates of Streptococcus pyogenes are generated by homophilic protein-protein interactions. Mol Microbiol 37:1232\u20131247","journal-title":"Mol Microbiol"},{"key":"12_CR28","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1084\/jem.191.11.1829","volume":"191","author":"N Gautam","year":"2000","unstructured":"Gautam N, Herwald H, Hedqvist P, Lindbom L (2000) Signaling via \u03b22 integrins triggers neutrophil-dependent alteration in endothelial barrier function. J Exp Med 191:1829\u20131839","journal-title":"J Exp Med"},{"key":"12_CR29","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1038\/nm1001-1123","volume":"7","author":"N Gautam","year":"2001","unstructured":"Gautam N, Olofsson AM, Herwald H, Iversen LF, Lundgren-Akerlund E, Hedqvist P, Arfors KE, Flodgaard H, Lindbom L (2001) Heparin-binding protein (HBP\/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability. Nat Med 7:1123\u20131127","journal-title":"Nat Med"},{"key":"12_CR30","doi-asserted-by":"publisher","first-page":"6596","DOI":"10.1073\/pnas.76.12.6596","volume":"76","author":"I Gigli","year":"1979","unstructured":"Gigli I, Fujita T, Nussenzweig V (1979) Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator. Proc Natl Acad Sci USA 76: 6596\u20136600","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR31","doi-asserted-by":"publisher","first-page":"8107","DOI":"10.1021\/bi962991s","volume":"36","author":"K Gubbe","year":"1997","unstructured":"Gubbe K, Misselwitz R, Welfle K, Reichardt W, Schmidt KH, Welfle H (1997) C repeats of the streptococcal M1 protein achieve the human serum albumin binding ability by flanking regions which stabilize the coiled-coil conformation. Biochemistry 36:8107\u20138113","journal-title":"Biochemistry"},{"key":"12_CR32","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0092-8674(04)00057-1","volume":"116","author":"H Herwald","year":"2004","unstructured":"Herwald H, Cramer H, M\u00f6rgelin M, Russell W, Sollenberg U, Norrby-Teglund A, Flodgaard H, Lindbom L, Bj\u00f6rck L (2004) M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Cell 116:367\u2013379","journal-title":"Cell"},{"key":"12_CR33","doi-asserted-by":"publisher","first-page":"5543","DOI":"10.1073\/pnas.91.12.5543","volume":"91","author":"SA Huber","year":"1994","unstructured":"Huber SA, Moraska A, Cunningham M (1994) Alterations in major histocompatibility complex association of myocarditis induced by coxsackievirus B3 mutants selected with monoclonal antibodies to group A streptococci. Proc Natl Acad Sci USA 91:5543\u20135547","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR34","doi-asserted-by":"publisher","first-page":"3690","DOI":"10.1074\/jbc.M511563200","volume":"281","author":"HT Jenkins","year":"2006","unstructured":"Jenkins HT, Mark L, Ball G, Persson J, Lindahl G, Uhrin D, Blom AM, Barlow PN (2006) Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. J Biol Chem 281:3690\u20133697","journal-title":"J Biol Chem"},{"key":"12_CR35","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.4049\/jimmunol.161.9.4894","volume":"161","author":"E Johnsson","year":"1998","unstructured":"Johnsson E, Bergg\u00e5rd K, Kotarsky H, Hellwage J, Zipfel PF, Sj\u00f6bring U, Lindahl G (1998) Role of the hypervariable region in streptococcal M proteins: binding of a human complement inhibitor. J Immunol 161:4894\u20134901","journal-title":"J Immunol"},{"key":"12_CR36","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1084\/jem.167.3.1114","volume":"167","author":"KF Jones","year":"1988","unstructured":"Jones KF, Fischetti VA (1988) The importance of the location of antibody binding on the M6 protein for opsonization and phagocytosis of group A M6 streptococci. J Exp Med 167: 1114\u20131123","journal-title":"J Exp Med"},{"key":"12_CR37","doi-asserted-by":"publisher","first-page":"e1000149","DOI":"10.1371\/journal.ppat.1000149","volume":"4","author":"F Kahn","year":"2008","unstructured":"Kahn F, M\u00f6rgelin M, Shannon O, Norrby-Teglund A, Herwald H, Olin AI, Bj\u00f6rck L (2008) Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response. PLoS Pathog 4:e1000149","journal-title":"PLoS Pathog"},{"key":"12_CR38","doi-asserted-by":"publisher","first-page":"6362","DOI":"10.1128\/IAI.68.11.6362-6369.2000","volume":"68","author":"RG Kansal","year":"2000","unstructured":"Kansal RG, McGeer A, Low DE, Norrby-Teglund A, Kotb M (2000) Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases. Infect Immun 68:6362\u20136369","journal-title":"Infect Immun"},{"key":"12_CR39","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1046\/j.1365-2958.2001.02496.x","volume":"41","author":"H Kotarsky","year":"2001","unstructured":"Kotarsky H, Gustafsson M, Svensson HG, Zipfel PF, Truedsson L, Sj\u00f6bring U (2001) Group A streptococcal phagocytosis resistance is independent of complement factor H and factor H-like protein 1 binding. Mol Microbiol 41:817\u2013826","journal-title":"Mol Microbiol"},{"key":"12_CR40","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1084\/jem.47.1.91","volume":"47","author":"RC Lancefield","year":"1928","unstructured":"Lancefield RC (1928) The antigenic complex of streptococcus haemolyticus: I. Demonstration of a Type-Specific Substance in Extracts of Streptococcus Haemolyticus. J Exp Med 47:91\u2013103","journal-title":"J Exp Med"},{"key":"12_CR41","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000203645","volume":"1","author":"X Lauth","year":"2009","unstructured":"Lauth X, von K\u00f6ckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V (2009) M1 protein allows group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun 1:202\u2013214","journal-title":"J Innate Immun"},{"key":"12_CR42","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nature01801","volume":"424","author":"Y Li","year":"2003","unstructured":"Li Y, Brown JH, Reshetnikova L, Blazsek A, Farkas L, Nyitray L, Cohen C (2003) Visualization of an unstable coiled coil from the scallop myosin rod. Nature 424:341\u2013345","journal-title":"Nature"},{"key":"12_CR43","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1086\/605563","volume":"49","author":"A Linder","year":"2009","unstructured":"Linder A, Christensson B, Herwald H, Bj\u00f6rck L, \u00c5kesson P (2009) Heparin-binding protein: an early marker of circulatory failure in sepsis. Clin Infect Dis 49:1044\u20131050","journal-title":"Clin Infect Dis"},{"key":"12_CR44","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1084\/jem.151.3.695","volume":"151","author":"BN Manjula","year":"1980","unstructured":"Manjula BN, Fischetti VA (1980) Tropomyosin-like seven residue periodicity in three immunologically distinct streptococal M proteins and its implications for the antiphagocytic property of the molecule. J Exp Med 151:695\u2013708","journal-title":"J Exp Med"},{"key":"12_CR45","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1126\/science.1154470","volume":"319","author":"C McNamara","year":"2008","unstructured":"McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P (2008) Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence. Science 319:1405\u20131408","journal-title":"Science"},{"key":"12_CR46","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.4049\/jimmunol.167.7.3870","volume":"167","author":"E Morfeldt","year":"2001","unstructured":"Morfeldt E, Bergg\u00e5rd K, Persson J, Drakenberg T, Johnsson E, Lindahl E, Linse S, Lindahl G (2001) Isolated hypervariable regions derived from streptococcal M proteins specifically bind human C4b-binding protein: implications for antigenic variation. J Immunol 167:3870\u20133877","journal-title":"J Immunol"},{"key":"12_CR47","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1128\/MMBR.63.1.174-229.1999","volume":"63","author":"WW Navarre","year":"1999","unstructured":"Navarre WW, Schneewind O (1999) Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol Mol Biol Rev 63:174\u2013229","journal-title":"Microbiol Mol Biol Rev"},{"key":"12_CR48","doi-asserted-by":"publisher","first-page":"13688","DOI":"10.1021\/bi00041a051","volume":"34","author":"BH Nilson","year":"1995","unstructured":"Nilson BH, Frick IM, \u00c5kesson P, Fors\u00e9n S, Bj\u00f6rck L, \u00c5kerstr\u00f6m B, Wikstr\u00f6m M (1995) Structure and stability of protein H and the M1 protein from Streptococcus pyogenes. Implications for other surface proteins of gram-positive bacteria. Biochemistry 34:13688\u201313698","journal-title":"Biochemistry"},{"key":"12_CR49","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/j.1365-2958.2007.05974.x","volume":"67","author":"M Nilsson","year":"2008","unstructured":"Nilsson M, Wasylik S, M\u00f6rgelin M, Olin AI, Meijers JC, Derksen RH, de Groot PG, Herwald H (2008) The antibacterial activity of peptides derived from human \u03b2-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes. Mol Microbiol 67:482\u2013492","journal-title":"Mol Microbiol"},{"key":"12_CR50","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1073\/pnas.92.7.2489","volume":"92","author":"N Okada","year":"1995","unstructured":"Okada N, Liszewski MK, Atkinson JP, Caparon M (1995) Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci USA 92:2489\u20132493","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR51","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1086\/521264","volume":"45","author":"RE O\u2018Loughlin","year":"2007","unstructured":"O\u2018Loughlin RE, Roberson A, Cieslak PR, Lynfield R, Gershman K, Craig A, Albanese BA, Farley MM, Barrett NL, Spina NL, Beall B, Harrison LH, Reingold A, Van Beneden C (2007) Active Bacterial Core Surveillance T. The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000\u20132004. Clin Infect Dis 45:853\u2013862","journal-title":"Clin Infect Dis"},{"key":"12_CR52","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1099\/mic.0.2006\/003285-0","volume":"153","author":"LI P\u00e5hlman","year":"2007","unstructured":"P\u00e5hlman LI, Malmstr\u00f6m E, M\u00f6rgelin M, Herwald H (2007) M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes. Microbiology 153:2458\u20132464","journal-title":"Microbiology"},{"key":"12_CR53","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.4049\/jimmunol.177.2.1221","volume":"177","author":"LI P\u00e5hlman","year":"2006","unstructured":"P\u00e5hlman LI, M\u00f6rgelin M, Eckert J, Johansson L, Russell W, Riesbeck K, Soehnlein O, Lindbom L, Norrby-Teglund A, Schumann RR, Bj\u00f6rck L, Herwald H (2006) Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol 177:1221\u20131228","journal-title":"J Immunol"},{"key":"12_CR54","first-page":"404","volume":"10","author":"LI P\u00e5hlman","year":"2008","unstructured":"P\u00e5hlman LI, Olin AI, Darenberg J, M\u00f6rgelin M, Kotb M, Herwald H, Norrby-Teglund A (2008) Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation. Cell Microbiol 10:404\u2013414","journal-title":"Cell Microbiol"},{"key":"12_CR55","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1086\/652005","volume":"201","author":"TA Penfound","year":"2010","unstructured":"Penfound TA, Ofek I, Courtney HS, Hasty DL, Dale JB (2010) The NH(2)-Terminal region of Streptococcus pyogenes M5 protein confers protection against degradation by proteases and enhances mucosal colonization of mice. J Infect Dis 201:1580\u20131588","journal-title":"J Infect Dis"},{"key":"12_CR56","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1371\/journal.ppat.0020047","volume":"2","author":"J Persson","year":"2006","unstructured":"Persson J, Beall B, Linse S, Lindahl G (2006) Extreme sequence divergence but conserved ligand-binding specificity in Streptococcus pyogenes M protein. PLoS Pathog 2:e47","journal-title":"PLoS Pathog"},{"key":"12_CR57","doi-asserted-by":"publisher","first-page":"4689","DOI":"10.1073\/pnas.78.8.4689","volume":"78","author":"GN Phillips Jr","year":"1981","unstructured":"Phillips GN Jr, Flicker PF, Cohen C, Manjula BN, Fischetti VA (1981) Streptococcal M protein: \u03b1-helical coiled-coil structure and arrangement on the cell surface. Proc Natl Acad Sci USA 78:4689\u20134693","journal-title":"Proc Natl Acad Sci USA"},{"key":"12_CR58","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1046\/j.1365-2958.2000.02062.x","volume":"37","author":"U Ringdahl","year":"2000","unstructured":"Ringdahl U, Svensson HG, Kotarsky H, Gustafsson M, Weineisen M, Sj\u00f6bring U (2000) A role for the fibrinogen-binding regions of streptococcal M proteins in phagocytosis resistance. Mol Microbiol 37:1318\u20131326","journal-title":"Mol Microbiol"},{"key":"12_CR59","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1365-2958.2005.04913.x","volume":"59","author":"C Sandin","year":"2006","unstructured":"Sandin C, Carlsson F, Lindahl G (2006) Binding of human plasma proteins to Streptococcus pyogenes M protein determines the location of opsonic and non-opsonic epitopes. Mol Microbiol 59:20\u201330","journal-title":"Mol Microbiol"},{"key":"12_CR60","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/j.1365-2958.2007.05841.x","volume":"65","author":"O Shannon","year":"2007","unstructured":"Shannon O, Hertz\u00e9n E, Norrby-Teglund A, M\u00f6rgelin M, Sj\u00f6bring U, Bj\u00f6rck L (2007) Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation. Mol Microbiol 65:1147\u20131157","journal-title":"Mol Microbiol"},{"key":"12_CR61","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1183\/09031936.00173207","volume":"32","author":"O Soehnlein","year":"2008","unstructured":"Soehnlein O, Oehmcke S, Ma X, Rothfuchs AG, Frithiof R, van Rooijen N, M\u00f6rgelin M, Herwald H, Lindbom L (2008) Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein. Eur Respir J 32:405\u2013412","journal-title":"Eur Respir J"},{"key":"12_CR62","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.chom.2007.10.003","volume":"2","author":"M St\u00e5lhammar-Carlemalm","year":"2007","unstructured":"St\u00e5lhammar-Carlemalm M, Waldemarsson J, Johnsson E, Areschoug T, Lindahl G (2007) Nonimmunodominant regions are effective as building blocks in a streptococcal fusion protein vaccine. Cell Host Microbe 2:427\u2013434","journal-title":"Cell Host Microbe"},{"key":"12_CR63","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S1473-3099(09)70178-1","volume":"9","author":"AC Steer","year":"2009","unstructured":"Steer AC, Law I, Matatolu L, Beall BW, Carapetis JR (2009) Global emm type distribution of group A streptococci: systematic review and implications for vaccine development. Lancet Infect Dis 9:611\u2013616","journal-title":"Lancet Infect Dis"},{"key":"12_CR64","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1126\/science.1101245","volume":"305","author":"H Sun","year":"2004","unstructured":"Sun H, Ringdahl U, Homeister JW, Fay WP, Engleberg NC, Yang AY, Rozek LS, Wang X, Sjobring U, Ginsburg D (2004) Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science 305:1283\u20131286","journal-title":"Science"},{"key":"12_CR65","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1182\/blood.V99.5.1785","volume":"99","author":"H Tapper","year":"2002","unstructured":"Tapper H, Karlsson A, M\u00f6rgelin M, Flodgaard H, Herwald H (2002) Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles. Blood 99:1785\u20131793","journal-title":"Blood"},{"key":"12_CR66","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1006\/jmbi.2000.3866","volume":"300","author":"B Tripet","year":"2000","unstructured":"Tripet B, Wagschal K, Lavigne P, Mant CT, Hodges RS (2000) Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled-coil: 20 amino acid substitutions in position \u201cd\u201d. J Mol Biol 300:377\u2013402","journal-title":"J Mol Biol"},{"key":"12_CR67","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1110\/ps.8.11.2312","volume":"8","author":"K Wagschal","year":"1999","unstructured":"Wagschal K, Tripet B, Lavigne P, Mant C, Hodges RS (1999) The role of position a in determining the stability and oligomerization state of \u03b1-helical coiled coils: 20 amino acid stability coefficients in the hydrophobic core of proteins. Protein Sci 8:2312\u20132329","journal-title":"Protein Sci"},{"key":"12_CR68","doi-asserted-by":"publisher","first-page":"e7279","DOI":"10.1371\/journal.pone.0007279","volume":"4","author":"J Waldemarsson","year":"2009","unstructured":"Waldemarsson J, St\u00e5lhammar-Carlemalm M, Sandin C, Castellino FJ, Lindahl G (2009) Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence. PLoS One 4:e7279","journal-title":"PLoS One"}],"container-title":["Advances in Experimental Medicine and Biology","Bacterial Adhesion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-007-0940-9_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T23:33:23Z","timestamp":1674171203000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-94-007-0940-9_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"ISBN":["9789400709393","9789400709409"],"references-count":68,"URL":"https:\/\/doi.org\/10.1007\/978-94-007-0940-9_12","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2011]]},"assertion":[{"value":"21 March 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}