{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:44:38Z","timestamp":1773056678232,"version":"3.50.1"},"publisher-location":"Dordrecht","reference-count":92,"publisher":"Springer Netherlands","isbn-type":[{"value":"9789400721982","type":"print"},{"value":"9789400721999","type":"electronic"}],"license":[{"start":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T00:00:00Z","timestamp":1314748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T00:00:00Z","timestamp":1314748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-94-007-2199-9_13","type":"book-chapter","created":{"date-parts":[[2011,11,24]],"date-time":"2011-11-24T15:24:30Z","timestamp":1322148270000},"page":"247-264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vitamins B6 and Cancer"],"prefix":"10.1007","author":[{"given":"Sang Woon","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Friso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,31]]},"reference":[{"key":"13_CR1","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1016\/S0021-9258(19)50599-3","volume":"267","author":"VE Allgood","year":"1992","unstructured":"Allgood VE, Cidlowski JA (1992) Vitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamily. J Biol Chem 267:3819\u20133824","journal-title":"J Biol Chem"},{"key":"13_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0027-5107(01)00070-7","volume":"475","author":"BN Ames","year":"2001","unstructured":"Ames BN (2001) DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 475:7\u201320","journal-title":"Mutat Res"},{"key":"13_CR3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/ajcn\/75.4.616","volume":"75","author":"BN Ames","year":"2002","unstructured":"Ames BN, Elson-Schwab I, Silver EA (2002) High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): Relevance to genetic disease and polymorphisms. Am J Clin Nutr 75:616\u2013658","journal-title":"Am J Clin Nutr"},{"key":"13_CR4","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1017\/CBO9780511615191.010","volume-title":"Nutritional biochemistry of the vitamins","author":"D Bender","year":"2003","unstructured":"Bender D (2003) Vitamin B-6. In: Bender D (ed) Nutritional biochemistry of the vitamins. Cambridge University Press, Cambridge, pp 232\u2013269"},{"key":"13_CR5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/ajcn\/80.3.641","volume":"80","author":"O Bleie","year":"2004","unstructured":"Bleie O, Refsum H, Ueland PM, Vollset SE, Guttormsen AB, Nexo E, Schneede J, Nordrehaug JE, Nygard O (2004) Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention. Am J Clin Nutr 80:641\u2013648","journal-title":"Am J Clin Nutr"},{"key":"13_CR6","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/0090-4295(77)90101-7","volume":"10","author":"D Byar","year":"1977","unstructured":"Byar D, Blackard C (1977) Comparisons of placebo, pyridoxine, and topical thiotepa in preventing recurrence of stage I bladder cancer. Urology 10:556\u2013561","journal-title":"Urology"},{"key":"13_CR7","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/0020-711X(89)90006-2","volume":"21","author":"SC Chen","year":"1989","unstructured":"Chen SC, Daron HH, Aull JL (1989) Inhibition of thymidylate synthase by pyridoxal phosphate. Int J Biochem 21:1217\u20131221","journal-title":"Int J Biochem"},{"key":"13_CR8","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/sj.ejcn.1602439","volume":"60","author":"CH Cheng","year":"2006","unstructured":"Cheng CH, Chang SJ, Lee BJ, Lin KL, Huang YC (2006) Vitamin B6 supplementation increases immune responses in critically ill patients. Eur J Clin Nutr 60:1207\u20131213","journal-title":"Eur J Clin Nutr"},{"key":"13_CR9","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1158\/1055-9965.EPI-07-0683","volume":"16","author":"E Cho","year":"2007","unstructured":"Cho E, Holmes M, Hankinson SE, Willett WC (2007) Nutrients involved in one-carbon metabolism and risk of breast cancer among premenopausal women. Cancer Epidemiol Biomarkers Prev 16:2787\u20132790","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR10","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/jn\/129.11.1945","volume":"129","author":"SW Choi","year":"1999","unstructured":"Choi SW, Stickel F, Baik HW, Kim YI, Seitz HK, Mason JB (1999) Chronic alcohol consumption induces genomic but not p53-specific DNA hypomethylation in rat colon. J Nutr 129:1945\u20131950","journal-title":"J Nutr"},{"key":"13_CR11","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10545-005-0243-2","volume":"29","author":"PT Clayton","year":"2006","unstructured":"Clayton PT (2006) B(6)-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis 29:317\u2013326","journal-title":"J Inherit Metab Dis"},{"key":"13_CR12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ajcn\/80.3.539","volume":"80","author":"SA Craig","year":"2004","unstructured":"Craig SA (2004) Betaine in human nutrition. Am J Clin Nutr 80:539\u2013549","journal-title":"Am J Clin Nutr"},{"key":"13_CR13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/ajcn\/63.2.220","volume":"63","author":"ML Cravo","year":"1996","unstructured":"Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC (1996) Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status. Am J Clin Nutr 63:220\u2013224","journal-title":"Am J Clin Nutr"},{"key":"13_CR14","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1080\/01635588109513725","volume":"3","author":"DM DiSorbo","year":"1982","unstructured":"DiSorbo DM, Litwack G (1982) Vitamin B6 kills hepatoma cells in culture. Nutr Cancer 3:216\u2013222","journal-title":"Nutr Cancer"},{"key":"13_CR15","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1080\/01635588309513773","volume":"5","author":"DM DiSorbo","year":"1983","unstructured":"DiSorbo DM, Nathanson L (1983) High-dose pyridoxal supplemented culture medium inhibits the growth of a human malignant melanoma cell line. Nutr Cancer 5:10\u201315","journal-title":"Nutr Cancer"},{"key":"13_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/01635588509513838","volume":"7","author":"DM DiSorbo","year":"1985","unstructured":"DiSorbo DM, Wagner R Jr, Nathanson L (1985) In vivo and in vitro inhibition of B16 melanoma growth by vitamin B6. Nutr Cancer 7:43\u201352","journal-title":"Nutr Cancer"},{"key":"13_CR17","doi-asserted-by":"publisher","first-page":"5606","DOI":"10.1073\/pnas.062066299","volume":"99","author":"S Friso","year":"2002","unstructured":"Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, Selhub J (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 99:5606\u20135611","journal-title":"Proc Natl Acad Sci USA"},{"key":"13_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/01635589009514074","volume":"14","author":"KJ Gebhard","year":"1990","unstructured":"Gebhard KJ, Gridley DS, Stickney DR, Shulz TD (1990) Enhancement of immune status by high levels of dietary vitamin B-6 without growth inhibition of human malignant melanoma in athymic nude mice. Nutr Cancer 14:15\u201326","journal-title":"Nutr Cancer"},{"key":"13_CR19","first-page":"951","volume":"78","author":"DS Gridley","year":"1987","unstructured":"Gridley DS, Stickney DR, Nutter RL, Slater JM, Shultz TD (1987) Suppression of tumor growth and enhancement of immune status with high levels of dietary vitamin B6 in BALB\/c mice. J Natl Cancer Inst 78:951\u2013959","journal-title":"J Natl Cancer Inst"},{"key":"13_CR20","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1207\/S15327914NC432_5","volume":"43","author":"L Harnack","year":"2002","unstructured":"Harnack L, Jacobs DR Jr, Nicodemus K, Lazovich D, Anderson K, Folsom AR (2002) Relationship of folate, vitamin B-6, vitamin B-12, and methionine intake to incidence of colorectal cancers. Nutr Cancer 43:152\u2013158","journal-title":"Nutr Cancer"},{"key":"13_CR21","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1093\/aje\/153.7.688","volume":"153","author":"TJ Hartman","year":"2001","unstructured":"Hartman TJ, Woodson K, Stolzenberg-Solomon R, Virtamo J, Selhub J, Barrett MJ, Albanes D (2001) Association of the B-vitamins pyridoxal 5\u2032-phosphate (B(6)), B(12), and folate with lung cancer risk in older men. Am J Epidemiol 153:688\u2013694","journal-title":"Am J Epidemiol"},{"key":"13_CR22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3109\/14756369209040746","volume":"6","author":"S Huang","year":"1992","unstructured":"Huang S, Parish EJ, Aull JL (1992) Irreversible inhibition of thymidylate synthase by pyridoxine (B6) analogues. J Enzyme Inhib 6:149\u2013156","journal-title":"J Enzyme Inhib"},{"key":"13_CR23","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S0891-5849(00)00462-7","volume":"30","author":"SK Jain","year":"2001","unstructured":"Jain SK, Lim G (2001) Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free Radic Biol Med 30:232\u2013237","journal-title":"Free Radic Biol Med"},{"key":"13_CR24","doi-asserted-by":"crossref","first-page":"G626","DOI":"10.1152\/ajpgi.2001.281.3.G626","volume":"281","author":"M Jaiswal","year":"2001","unstructured":"Jaiswal M, LaRusso NF, Gores GJ (2001) Nitric oxide in gastrointestinal epithelial cell carcinogenesis: Linking inflammation to oncogenesis. Am J Physiol Gastrointest Liver Physiol 281, G626\u2013634","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"13_CR25","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<174::AID-IJC2>3.0.CO;2-#","volume":"81","author":"MC Jansen","year":"1999","unstructured":"Jansen MC, Bueno-de-Mesquita HB, Buzina R, Fidanza F, Menotti A, Blackburn H, Nissinen AM, Kok FJ, Kromhout D (1999) Dietary fiber and plant foods in relation to colorectal cancer mortality: the Seven Countries Study. Int J Cancer 81:174\u2013179","journal-title":"Int J Cancer"},{"key":"13_CR26","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/ajcn\/58.4.468","volume":"58","author":"E Joosten","year":"1993","unstructured":"Joosten E, van den Berg A, Riezler R, Naurath HJ, Lindenbaum J, Stabler SP, Allen RH (1993) Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people. Am J Clin Nutr 58:468\u2013476","journal-title":"Am J Clin Nutr"},{"key":"13_CR27","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0026-0495(88)90076-5","volume":"37","author":"S-S Kang","year":"1988","unstructured":"Kang S-S, Wong PW K., Zhou J, Sora J, Lessick M, Ruggie N, Grcevich G (1988) Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism 37:611\u2013613","journal-title":"Metabolism"},{"key":"13_CR28","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/bjc.1997.445","volume":"76","author":"TJ Key","year":"1997","unstructured":"Key TJ, Silcocks PB, Davey GK, Appleby PN, Bishop DT (1997) A case-control study of diet and prostate cancer. Br J Cancer 76:678\u2013687","journal-title":"Br J Cancer"},{"key":"13_CR29","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1207\/S15327914NC4602_02","volume":"46","author":"JB Kirkland","year":"2003","unstructured":"Kirkland JB (2003) Niacin and carcinogenesis. Nutr Cancer 46:110\u2013118","journal-title":"Nutr Cancer"},{"key":"13_CR30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/(SICI)1096-9098(199904)70:4<222::AID-JSO5>3.0.CO;2-G","volume":"70","author":"M Kojima","year":"1999","unstructured":"Kojima M, Morisaki T, Tsukahara Y, Uchiyama A, Matsunari Y, Mibu R, Tanaka M (1999) Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue. J Surg Oncol 70:222\u2013229","journal-title":"J Surg Oncol"},{"key":"13_CR31","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1093\/jn\/131.8.2204","volume":"131","author":"SI Komatsu","year":"2001","unstructured":"Komatsu SI, Watanabe H, Oka T, Tsuge H, Nii H, Kato N (2001) Vitamin B-6-supplemented diets compared with a low vitamin B-6 diet suppress azoxymethane-induced colon tumorigenesis in mice by reducing cell proliferation. J Nutr 131:2204\u20132207","journal-title":"J Nutr"},{"key":"13_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3177\/jnsv.48.65","volume":"48","author":"S Komatsu","year":"2002","unstructured":"Komatsu S, Watanabe H, Oka T, Tsuge H, Kat N (2002) Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice. J Nutr Sci Vitaminol (Tokyo) 48:65\u201368","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"13_CR33","first-page":"265","volume":"14","author":"S Komatsu","year":"2005","unstructured":"Komatsu S, Isobe M, Yanaka N, Kato N (2005) A high-fat diet enhances the inhibitory effect of dietary vitamin B6 on colon cell proliferation in mice. Oncol Rep 14:265\u2013269","journal-title":"Oncol Rep"},{"key":"13_CR34","first-page":"585","volume":"46","author":"LG Koss","year":"1971","unstructured":"Koss LG, Lavin P (1971) Studies of experimental bladder carcinoma in Fischer 344 female rats. I. Induction of tumors with diet low in vitamin B6 containing N-2-fluorenylacetamide after single dose of cyclophosphamide. J Natl Cancer Inst 46:585\u2013595","journal-title":"J Natl Cancer Inst"},{"key":"13_CR35","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1158\/1055-9965.EPI-05-0532","volume":"15","author":"M Lajous","year":"2006","unstructured":"Lajous M, Lazcano-Ponce E, Hernandez-Avila M, Willett W, Romieu I (2006) Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev 15:443\u2013448","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-5347(17)34863-2","volume":"151","author":"DL Lamm","year":"1994","unstructured":"Lamm DL, Riggs DR, Shriver JS, vanGilder PF, Rach JF, DeHaven JI (1994) Megadose vitamins in bladder cancer: A double-blind clinical trial. J Urol 151:21\u201326","journal-title":"J Urol"},{"key":"13_CR37","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1053\/j.gastro.2005.03.005","volume":"128","author":"SC Larsson","year":"2005","unstructured":"Larsson SC, Giovannucci E, Wolk A (2005) Vitamin B6 intake, alcohol consumption, and colorectal cancer: A longitudinal population-based cohort of women. Gastroenterology 128:1830\u20131837","journal-title":"Gastroenterology"},{"key":"13_CR38","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1023\/A:1015057614870","volume":"13","author":"L Le Marchand","year":"2002","unstructured":"Le Marchand L, Donlon T, Hankin JH, Kolonel LN, Wilkens LR, Seifried A (2002) B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control 13:239\u2013248","journal-title":"Cancer Causes Control"},{"key":"13_CR39","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/aje\/kwi310","volume":"162","author":"U Lim","year":"2005","unstructured":"Lim U, Schenk M, Kelemen LE, Davis S, Cozen W, Hartge P, Ward MH, Stolzenberg-Solomon R (2005) Dietary determinants of one-carbon metabolism and the risk of non-Hodgkin\u2019s lymphoma: NCI-SEER case-control study, 1998\u20132000. Am J Epidemiol 162:953\u2013964","journal-title":"Am J Epidemiol"},{"key":"13_CR40","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1182\/blood-2006-07-034330","volume":"109","author":"U Lim","year":"2007","unstructured":"Lim U, Wang SS, Hartge P, Cozen W, Kelemen LE, Chanock S, Davis S, Blair A, Schenk M, Rothman N, Lan Q (2007) Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study. Blood 109:3050\u20133059","journal-title":"Blood"},{"key":"13_CR41","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1158\/1055-9965.EPI-05-0918","volume":"15","author":"U Lim","year":"2006","unstructured":"Lim U, Weinstein S, Albanes D, Pietinen P, Teerenhovi L, Taylor PR, Virtamo J, Stolzenberg-Solomon R (2006) Dietary factors of one-carbon metabolism in relation to non-Hodgkin lymphoma and multiple myeloma in a cohort of male smokers. Cancer Epidemiol Biomarkers Prev 15:1109\u20131114","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR42","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ajcn\/87.3.734","volume":"87","author":"J Lin","year":"2008","unstructured":"Lin J, Lee IM, Cook NR, Selhub J, Manson JE, Buring JE, Zhang SM (2008) Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women. Am J Clin Nutr 87:734\u2013743","journal-title":"Am J Clin Nutr"},{"key":"13_CR43","volume-title":"Biogenesis and interconversion of substituted tetrahydrofolates","author":"R MacKenzie","year":"1984","unstructured":"MacKenzie R (1984) Biogenesis and interconversion of substituted tetrahydrofolates, vol 1. Wiley, New York"},{"key":"13_CR44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/00365519950185562","volume":"59","author":"MA Mansoor","year":"1999","unstructured":"Mansoor MA, Kristensen O, Hervig T, Bates CJ, Pentieva K, Vefring H, Osland A, Berge T, Drablos PA, Hetland O, Rolfsen S (1999) Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate. Scand J Clin Lab Invest 59:139\u2013146","journal-title":"Scand J Clin Lab Invest"},{"key":"13_CR45","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/jn\/130.5.1115","volume":"130","author":"M Martinez","year":"2000","unstructured":"Martinez M, Cuskelly GJ, Williamson J, Toth JP, Gregory JF 3rd (2000) Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J Nutr 130:1115\u20131123","journal-title":"J Nutr"},{"key":"13_CR46","first-page":"505","volume":"8","author":"K Matsubara","year":"2001","unstructured":"Matsubara K, Mori M, Matsuura Y, Kato N (2001) Pyridoxal 5\u2032-phosphate and pyridoxal inhibit angiogenesis in serum-free rat aortic ring assay. Int J Mol Med 8:505\u2013508","journal-title":"Int J Mol Med"},{"key":"13_CR47","first-page":"51","volume":"12","author":"K Matsubara","year":"2003","unstructured":"Matsubara K, Matsumoto H, Mizushina Y, Lee JS, Kato N (2003) Inhibitory effect of pyridoxal 5\u2032-phosphate on endothelial cell proliferation, replicative DNA polymerase and DNA topoisomerase. Int J Mol Med 12:51\u201355","journal-title":"Int J Mol Med"},{"key":"13_CR48","first-page":"819","volume":"14","author":"K Matsubara","year":"2004","unstructured":"Matsubara K, Mori M, Akagi R, Kato N (2004) Anti-angiogenic effect of pyridoxal 5\u2032-phosphate, pyridoxal and pyridoxamine on embryoid bodies derived from mouse embryonic stem cells. Int J Mol Med 14:819\u2013823","journal-title":"Int J Mol Med"},{"key":"13_CR49","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1080\/01635589709514576","volume":"28","author":"A Molina","year":"1997","unstructured":"Molina A, Oka T, Munoz SM, Chikamori-Aoyama M, Kuwahata M, Natori Y (1997) Vitamin B6 suppresses growth and expression of albumin gene in a human hepatoma cell line HepG2. Nutr Cancer 28:206\u2013211","journal-title":"Nutr Cancer"},{"key":"13_CR50","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.bbrc.2003.11.027","volume":"312","author":"Y Mizushina","year":"2003","unstructured":"Mizushina Y, Xu X, Matsubara K, Murakami C, Kuriyama I, Oshige M, Takemura M, Kato N, Yoshida H, Sakaguchi K (2003) Pyridoxal 5\u2032-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon. Biochem Biophys Res Commun 312:1025\u20131032","journal-title":"Biochem Biophys Res Commun"},{"key":"13_CR51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000475139","volume":"27","author":"DW Newling","year":"1995","unstructured":"Newling DW, Robinson MR, Smith PH, Byar D, Lockwood R, Stevens I, De Pauw M, Sylvester R (1995) Tryptophan metabolites, pyridoxine (vitamin B6) and their influence on the recurrence rate of superficial bladder cancer. Results of a prospective, randomised phase III study performed by the EORTC GU Group. EORTC Genito-Urinary Tract Cancer Cooperative Group. Eur Urol 27:110\u2013116","journal-title":"Eur Urol"},{"key":"13_CR52","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1053\/euhj.2002.3172","volume":"23","author":"P O\u2019Callaghan","year":"2002","unstructured":"O\u2019Callaghan P, Meleady R, Fitzgerald T, Graham I (2002) Smoking and plasma homocysteine. Eur Heart J 23:1580\u20131586","journal-title":"Eur Heart J"},{"key":"13_CR53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1079\/095442201108729231","volume":"14","author":"T Oka","year":"2001","unstructured":"Oka T (2001) Modulation of gene expression by vitamin B6. Nutr Res Rev 14:257\u2013265","journal-title":"Nutr Res Rev"},{"key":"13_CR54","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1207\/s15327914nc5301_5","volume":"53","author":"T Otani","year":"2005","unstructured":"Otani T, Iwasaki M, Hanaoka T, Kobayashi M, Ishihara J, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Yoshimura K, Yoshida T, Tsugane S (2005) Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. Nutr Cancer 53:42\u201350","journal-title":"Nutr Cancer"},{"key":"13_CR55","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1158\/1055-9965.EPI-04-0787","volume":"14","author":"C Pelucchi","year":"2005","unstructured":"Pelucchi C, Galeone C, Talamini R, Negri E, Parpinel M, Franceschi S, Montella M, La Vecchia C (2005) Dietary folate and risk of prostate cancer in Italy. Cancer Epidemiol Biomarkers Prev 14:944\u2013948","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR56","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/ajcn\/30.10.1677","volume":"30","author":"C Potera","year":"1977","unstructured":"Potera C, Rose DP, Brown RR (1977) Vitamin B6 deficiency in cancer patients. Am J Clin Nutr 30:1677\u20131679","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 1","key":"13_CR57","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.etp.2005.05.015","volume":"57","author":"HE Poulsen","year":"2005","unstructured":"Poulsen HE (2005) Oxidative DNA modifications. Exp Toxicol Pathol 57(Suppl 1):161\u2013169","journal-title":"Exp Toxicol Pathol"},{"key":"13_CR58","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/0306-9877(85)90064-7","volume":"16","author":"FG Prior","year":"1985","unstructured":"Prior FG (1985) Theoretical involvement of vitamin B6 in tumour initiation. Med Hypotheses 16:421\u2013428","journal-title":"Med Hypotheses"},{"key":"13_CR59","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1753-4887.1993.tb03109.x","volume":"51","author":"LC Rall","year":"1993","unstructured":"Rall LC, Meydani SN (1993) Vitamin B6 and immune competence. Nutr Rev 51:217\u2013225","journal-title":"Nutr Rev"},{"key":"13_CR60","doi-asserted-by":"publisher","first-page":"3936","DOI":"10.1210\/en.2005-1219","volume":"147","author":"SG Ren","year":"2006","unstructured":"Ren SG, Melmed S (2006) Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion. Endocrinology 147:3936\u20133942","journal-title":"Endocrinology"},{"key":"13_CR61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/jn\/135.2.233","volume":"135","author":"JB Scheer","year":"2005","unstructured":"Scheer JB, Mackey AD, Gregory JF 3rd (2005) Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats. J Nutr 135:233\u2013238","journal-title":"J Nutr"},{"key":"13_CR62","doi-asserted-by":"publisher","first-page":"5553","DOI":"10.1158\/0008-5472.CAN-06-4463","volume":"67","author":"E Schernhammer","year":"2007","unstructured":"Schernhammer E, Wolpin B, Rifai N, Cochrane B, Manson JA, Ma J, Giovannucci E, Thomson C, Stampfer MJ, Fuchs C (2007) Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res 67:5553\u20135560","journal-title":"Cancer Res"},{"key":"13_CR63","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1001\/jama.270.22.2693","volume":"270","author":"J Selhub","year":"1993","unstructured":"Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693\u20132698","journal-title":"JAMA"},{"key":"13_CR64","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0083-6729(08)60397-0","volume":"45","author":"B Shane","year":"1989","unstructured":"Shane B (1989) Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. Vitam Horm 45:263\u2013335","journal-title":"Vitam Horm"},{"key":"13_CR65","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1017\/S0007114507801073","volume":"99","author":"L Sharp","year":"2008","unstructured":"Sharp L, Little J, Brockton NT, Cotton SC, Masson LF, Haites NE, Cassidy J (2008) Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: A case-control study in a population with relatively low folate intake. Br J Nutr 99:379\u2013389","journal-title":"Br J Nutr"},{"key":"13_CR66","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1158\/1055-9965.EPI-04-0905","volume":"14","author":"Q Shi","year":"2005","unstructured":"Shi Q, Zhang Z, Li G, Pillow PC, Hernandez LM, Spitz MR, Wei Q (2005) Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms. Cancer Epidemiol Biomarkers Prev 14:1477\u20131484","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR67","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1271\/bbb.59.2060","volume":"59","author":"K Shibata","year":"1995","unstructured":"Shibata K, Mushiage M, Kondo T, Hayakawa T, Tsuge H (1995) Effects of vitamin B6 deficiency on the conversion ratio of tryptophan to niacin. Biosci Biotechnol Biochem 59:2060\u20132063","journal-title":"Biosci Biotechnol Biochem"},{"key":"13_CR68","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1207\/s15327914nc5302_9","volume":"53","author":"D Shimada","year":"2005","unstructured":"Shimada D, Fukuda A, Kawaguchi H, Kato N, Yoshida H, Kanouchi H, Oka T (2005) Effect of high dose of pyridoxine on mammary tumorigenesis. Nutr Cancer 53:202\u2013207","journal-title":"Nutr Cancer"},{"key":"13_CR69","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1271\/bbb.70.1038","volume":"70","author":"D Shimada","year":"2006","unstructured":"Shimada D, Fukuda A, Kanouchi H, Matsumoto M, Oka T (2006) Vitamin B6 suppresses growth of the feline mammary tumor cell line FRM. Biosci Biotechnol Biochem 70:1038\u20131040","journal-title":"Biosci Biotechnol Biochem"},{"key":"13_CR70","first-page":"7136","volume":"61","author":"MJ Shrubsole","year":"2001","unstructured":"Shrubsole MJ, Jin F, Dai Q, Shu XO, Potter JD, Hebert JR, Gao YT, Zheng W (2001) Dietary folate intake and breast cancer risk: Results from the Shanghai Breast Cancer Study. Cancer Res 61:7136\u20137141","journal-title":"Cancer Res"},{"key":"13_CR71","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1158\/1055-9965.EPI-03-0273","volume":"13","author":"MJ Shrubsole","year":"2004","unstructured":"Shrubsole MJ, Gao YT, Cai Q, Shu XO, Dai Q, Hebert JR, Jin F, Zheng W (2004) MTHFR polymorphisms, dietary folate intake, and breast cancer risk: Results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 13:190\u2013196","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR72","first-page":"1313","volume":"8","author":"TD Shultz","year":"1988","unstructured":"Shultz TD, Santamaria AG, Gridley DS, Stickney DR, Slater JM (1988) Effect of pyridoxine and pyridoxal on the in vitro growth of human malignant melanoma. Anticancer Res 8:1313\u20131318","journal-title":"Anticancer Res"},{"key":"13_CR73","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1023\/A:1018490212481","volume":"8","author":"ML Slattery","year":"1997","unstructured":"Slattery ML, Potter JD, Coates A, Ma KN, Berry TD, Duncan DM, Caan BJ (1997) Plant foods and colon cancer: An assessment of specific foods and their related nutrients (United States). Cancer Causes Control 8:575\u2013590","journal-title":"Cancer Causes Control"},{"key":"13_CR74","first-page":"513","volume":"8","author":"ML Slattery","year":"1999","unstructured":"Slattery ML, Potter JD, Samowitz W, Schaffer D, Leppert M (1999) Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 8:513\u2013518","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR75","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1530-0277.2000.tb04606.x","volume":"24","author":"F Stickel","year":"2000","unstructured":"Stickel F, Choi SW, Kim YI, Bagley PJ, Seitz HK, Russell RM, Selhub J, Mason JB (2000) Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res 24:259\u2013264","journal-title":"Alcohol Clin Exp Res"},{"key":"13_CR76","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1093\/jnci\/91.6.535","volume":"91","author":"RZ Stolzenberg-Solomon","year":"1999","unstructured":"Stolzenberg-Solomon RZ, Albanes D, Nieto FJ, Hartman TJ, Tangrea JA, Rautalahti M, Sehlub J, Virtamo J, Taylor PR (1999) Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. J Natl Cancer Inst 91:535\u2013541","journal-title":"J Natl Cancer Inst"},{"key":"13_CR77","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1093\/aje\/153.7.680","volume":"153","author":"RZ Stolzenberg-Solomon","year":"2001","unstructured":"Stolzenberg-Solomon RZ, Pietinen P, Barrett MJ, Taylor PR, Virtamo J, Albanes D (2001) Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers. Am J Epidemiol 153:680\u2013687","journal-title":"Am J Epidemiol"},{"key":"13_CR78","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.clnu.2004.12.001","volume":"24","author":"S Taysi","year":"2005","unstructured":"Taysi S (2005) Oxidant\/antioxidant status in liver tissue of vitamin B6 deficient rats. Clin Nutr 24:385\u2013389","journal-title":"Clin Nutr"},{"key":"13_CR79","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1016\/S0021-9258(19)69617-1","volume":"256","author":"JW Thanassi","year":"1981","unstructured":"Thanassi JW, Nutter LM, Meisler NT, Commers P, Chiu JF (1981) Vitamin B6 metabolism in Morris hepatomas. J Biol Chem 256:3370\u20133375","journal-title":"J Biol Chem"},{"key":"13_CR80","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1158\/1055-9965.EPI-07-0621","volume":"17","author":"E Theodoratou","year":"2008","unstructured":"Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, Barnetson RA, Porteous ME, Dunlop MG, Campbell H (2008) Dietary vitamin B6 intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 17:171\u2013182","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR81","doi-asserted-by":"publisher","first-page":"G588","DOI":"10.1152\/ajpgi.00454.2003","volume":"286","author":"JH Townsend","year":"2004","unstructured":"Townsend JH, Davis SR, Mackey AD, Gregory JF 3rd (2004) Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: Role of serine in one-carbon donation. Am J Physiol Gastrointest Liver Physiol 286:G588\u2013G595","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"13_CR82","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0014-2964(76)90117-1","volume":"12","author":"GP Tryfiates","year":"1976","unstructured":"Tryfiates GP, Morris HP (1976) Growth of Morris hepatoma No. 7794A with and without vitamin B6. Effect of inoculation time. Eur J Cancer 12:9\u201312","journal-title":"Eur J Cancer"},{"key":"13_CR83","first-page":"659","volume":"8","author":"CM Ulrich","year":"1999","unstructured":"Ulrich CM, Kampman E, Bigler J, Schwartz SM, Chen C, Bostick R, Fosdick L, Beresford SA, Yasui Y, Potter JD (1999) Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev 8:659\u2013668","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR84","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/ajcn\/51.6.1058","volume":"51","author":"WJ Vermaak","year":"1990","unstructured":"Vermaak WJ, Ubbink JB, Barnard HC, Potgieter GM, van Jaarsveld H, Groenewald AJ (1990) Vitamin B-6 nutrition status and cigarette smoking. Am J Clin Nutr 51:1058\u20131061","journal-title":"Am J Clin Nutr"},{"key":"13_CR85","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3181\/00379727-105-26177","volume":"105","author":"M Wachstein","year":"1960","unstructured":"Wachstein M, Kellner JD, Ortiz JM (1960) Pyridoxal phosphate in plasma and leukocytes in patients with leukemia and other diseases. Proc Soc Exp Biol Med 105:563\u2013566","journal-title":"Proc Soc Exp Biol Med"},{"key":"13_CR86","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1093\/jnci\/dji116","volume":"97","author":"EK Wei","year":"2005","unstructured":"Wei EK, Giovannucci E, Selhub J, Fuchs CS, Hankinson SE, Ma J (2005) Plasma vitamin B6 and the risk of colorectal cancer and adenoma in women. J Natl Cancer Inst 97:684\u2013692","journal-title":"J Natl Cancer Inst"},{"key":"13_CR87","first-page":"1271","volume":"12","author":"SJ Weinstein","year":"2003","unstructured":"Weinstein SJ, Hartman TJ, Stolzenberg-Solomon R, Pietinen P, Barrett MJ, Taylor PR, Virtamo J, Albanes D (2003) Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteine. Cancer Epidemiol Biomarkers Prev 12:1271\u20131272","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR88","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/ajcn\/84.4.929","volume":"84","author":"SJ Weinstein","year":"2006","unstructured":"Weinstein SJ, Stolzenberg-Solomon R, Pietinen P, Taylor PR, Virtamo J, Albanes D (2006) Dietary factors of one-carbon metabolism and prostate cancer risk. Am J Clin Nutr 84:929\u2013935","journal-title":"Am J Clin Nutr"},{"key":"13_CR89","first-page":"209","volume":"8","author":"K Wu","year":"1999","unstructured":"Wu K, Helzlsouer KJ, Comstock GW, Hoffman SC, Nadeau MR, Selhub J (1999) A prospective study on folate, B12, and pyridoxal 5\u2032-phosphate (B6) and breast cancer [In Process Citation]. Cancer Epidemiol Biomarkers Prev 8:209\u2013217","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"13_CR90","first-page":"1071","volume":"16","author":"N Yanaka","year":"2005","unstructured":"Yanaka N, Koyama TA, Komatsu S, Nakamura E, Kanda M, Kato N (2005) Vitamin B6 suppresses NF-kappaB activation in LPS-stimulated mouse macrophages. Int J Mol Med 16:1071\u20131075","journal-title":"Int J Mol Med"},{"key":"13_CR91","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/jnci\/95.5.373","volume":"95","author":"SM Zhang","year":"2003","unstructured":"Zhang SM, Willett WC, Selhub J, Hunter DJ, Giovannucci EL, Holmes MD, Colditz GA, Hankinson SE (2003) Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer. J Natl Cancer Inst 95:373\u2013380","journal-title":"J Natl Cancer Inst"},{"key":"13_CR92","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1093\/aje\/kwj016","volume":"163","author":"SM Zhang","year":"2006","unstructured":"Zhang SM, Moore SC, Lin J, Cook NR, Manson JE, Lee IM, Buring JE (2006) Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women. Am J Epidemiol 163:108\u2013115","journal-title":"Am J Epidemiol"}],"container-title":["Subcellular Biochemistry","Water Soluble Vitamins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-007-2199-9_13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T04:36:08Z","timestamp":1675917368000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-94-007-2199-9_13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,31]]},"ISBN":["9789400721982","9789400721999"],"references-count":92,"URL":"https:\/\/doi.org\/10.1007\/978-94-007-2199-9_13","relation":{},"ISSN":["0306-0225"],"issn-type":[{"value":"0306-0225","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8,31]]},"assertion":[{"value":"31 August 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}