{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:04:27Z","timestamp":1782421467941,"version":"3.54.5"},"publisher-location":"Dordrecht","reference-count":19,"publisher":"Springer Netherlands","isbn-type":[{"value":"9789400745834","type":"print"},{"value":"9789400745841","type":"electronic"}],"license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-94-007-4584-1_40","type":"book-chapter","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T21:50:28Z","timestamp":1350597028000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat"],"prefix":"10.1007","author":[{"given":"Deirdre","family":"Edge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Bradford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F. X.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken D.","family":"O\u2019Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,8]]},"reference":[{"key":"40_CR1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.resp.2011.04.018","volume":"179","author":"EF Bailey","year":"2011","unstructured":"Bailey EF (2011) Activities of human genioglossus motor units. Respir Physiol Neurobiol 179:14\u201322","journal-title":"Respir Physiol Neurobiol"},{"key":"40_CR2","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1164\/rccm.200308-1100OC","volume":"170","author":"JH Boyd","year":"2004","unstructured":"Boyd JH, Petrof BJ, Hamid Q, Fraser R, Kimoff RJ (2004) Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J Respir Crit Care Med 170:541\u2013546","journal-title":"Am J Respir Crit Care Med"},{"key":"40_CR3","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.resp.2005.04.001","volume":"147","author":"A Bradford","year":"2005","unstructured":"Bradford A, McGuire M, O\u2019Halloran KD (2005) Does episodic hypoxia affect upper airway dilator muscle function? implications for the pathophysiology of obstructive sleep apnoea. Respir Physiol Neurobiol 147:223\u2013234","journal-title":"Respir Physiol Neurobiol"},{"key":"40_CR4","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1152\/jappl.1979.46.4.772","volume":"46","author":"RT Brouillette","year":"1979","unstructured":"Brouillette RT, Thach BT (1979) A neuromuscular mechanism maintaining extrathoracic airway patency. J Appl Physiol 46:772\u2013779","journal-title":"J Appl Physiol"},{"key":"40_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0034-5687(00)00124-9","volume":"121","author":"DD Fuller","year":"2000","unstructured":"Fuller DD, Bach KB, Baker TL, Kinkead R, Mitchell GS (2000) Long term facilitation of phrenic motor output. Respir Physiol 121:135\u2013146","journal-title":"Respir Physiol"},{"key":"40_CR6","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1126\/science.126.3287.1345","volume":"126","author":"E Henneman","year":"1957","unstructured":"Henneman E (1957) Relation between size of neurons and their susceptibility to discharge. Science 126:1345\u20131347","journal-title":"Science"},{"key":"40_CR7","doi-asserted-by":"publisher","first-page":"R1274","DOI":"10.1152\/ajpregu.90346.2008","volume":"295","author":"J Jun","year":"2008","unstructured":"Jun J, Savransky V, Nanayakkara A, Bevans S, Li J, Smith PL, Polotsky VY (2008) Intermittent hypoxia has organ-specific effects on oxidative stress. Am J Physiol Regul Integr Comp Physiol 295:R1274\u2013R1281","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"40_CR8","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1378\/chest.122.4.1400","volume":"122","author":"M McGuire","year":"2002","unstructured":"McGuire M, Macdermott M, Bradford A (2002a) The effects of chronic episodic hypercapnic hypoxia on rat upper airway muscle contractile properties and fiber-type distribution. Chest 122:1400\u20131406","journal-title":"Chest"},{"key":"40_CR9","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1378\/chest.122.3.1012","volume":"122","author":"M McGuire","year":"2002","unstructured":"McGuire M, Macdermott M, Bradford A (2002b) Effects of chronic episodic hypoxia on rat upper airway muscle contractile properties and fiber-type distribution. Chest 122:1012\u20131017","journal-title":"Chest"},{"key":"40_CR10","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/sleep\/33.5.1529","volume":"33","author":"CL Nicholas","year":"2010","unstructured":"Nicholas CL, Bei B, Worsnop C, Malhotra A, Jordan AS, Saboisky JP, Chan JK, Duckworth E, White DP, Trinder J (2010) Motor unit recruitment in human genioglossus muscle in response to hypercapnia. Sleep 33:1529\u20131538","journal-title":"Sleep"},{"key":"40_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1378\/chest.122.1.269","volume":"122","author":"KD O\u2019Halloran","year":"2002","unstructured":"O\u2019Halloran KD, McGuire M, O\u2019Hare T, Bradford A (2002) Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia. Chest 122:269\u2013275","journal-title":"Chest"},{"key":"40_CR12","doi-asserted-by":"publisher","first-page":"10073","DOI":"10.1073\/pnas.1734109100","volume":"100","author":"YJ Peng","year":"2003","unstructured":"Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR (2003) Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci U S A 100:10073\u201310078","journal-title":"Proc Natl Acad Sci U S A"},{"key":"40_CR13","doi-asserted-by":"publisher","first-page":"R372","DOI":"10.1152\/ajpregu.00038.2007","volume":"293","author":"AD Ray","year":"2007","unstructured":"Ray AD, Magalang UJ, Michlin CP, Ogasa T, Krasney JA, Gosselin LE, Farkas GA (2007) Intermittent hypoxia reduces upper airway stability in lean but not obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 293:R372\u2013R378","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"40_CR14","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1152\/jappl.1978.44.6.931","volume":"44","author":"JE Remmers","year":"1978","unstructured":"Remmers JE, Degroot WJ, Sauerland EK, Anch AM (1978) Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 44:931\u2013938","journal-title":"J Appl Physiol"},{"key":"40_CR15","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1164\/rccm.200209-1050OC","volume":"167","author":"BW Row","year":"2003","unstructured":"Row BW, Liu R, Xu W, Kheirandish L, Gozal D (2003) Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. Am J Respir Crit Care Med 167:1548\u20131553","journal-title":"Am J Respir Crit Care Med"},{"key":"40_CR16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1113\/jphysiol.2007.139584","volume":"585","author":"JP Saboisky","year":"2007","unstructured":"Saboisky JP, Butler JE, McKenzie DK, Gorman RB, Trinder JA, White DP, Gandevia SC (2007) Neural drive to human genioglossus in obstructive sleep apnoea. J Physiol 585:135\u2013146","journal-title":"J Physiol"},{"key":"40_CR17","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1152\/japplphysiol.00812.2010","volume":"109","author":"JP Saboisky","year":"2010","unstructured":"Saboisky JP, Jordan AS, Eckert DJ, White DP, Trinder JA, Nicholas CL, Gautam S, Malhotra A (2010) Recruitment and rate-coding strategies of the human genioglossus muscle. J Appl Physiol 109:1939\u20131949","journal-title":"J Appl Physiol"},{"key":"40_CR18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1165\/rcmb.2011-0084OC","volume":"46","author":"JR Skelly","year":"2011","unstructured":"Skelly JR, Edge D, Shortt CM, Jones JFX, Bradford A, O\u2019Hallorn KD (2011) Tempol ameliorates pharyngeal dilator muscle dysfunction in a rodent model of chronic intermittent hypoxia. Am J Respir Cell Mol Biol 46:139\u2013148","journal-title":"Am J Respir Cell Mol Biol"},{"key":"40_CR19","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1164\/rccm.200403-261OC","volume":"170","author":"SC Veasey","year":"2004","unstructured":"Veasey SC, Zhan G, Fenik P, Pratico D (2004) Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output. Am J Respir Crit Care Med 170:665\u2013672","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Advances in Experimental Medicine and Biology","Arterial Chemoreception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-007-4584-1_40","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T03:12:43Z","timestamp":1676171563000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-94-007-4584-1_40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9789400745834","9789400745841"],"references-count":19,"URL":"https:\/\/doi.org\/10.1007\/978-94-007-4584-1_40","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"8 August 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}