{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:12:23Z","timestamp":1790665943376,"version":"4.1.0"},"publisher-location":"Dordrecht","reference-count":31,"publisher":"Springer Netherlands","isbn-type":[{"value":"9789400745834","type":"print"},{"value":"9789400745841","type":"electronic"}],"license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-94-007-4584-1_46","type":"book-chapter","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T21:50:28Z","timestamp":1350597028000},"page":"343-349","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Role of Central\/Peripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea"],"prefix":"10.1007","author":[{"given":"Jerome A.","family":"Dempsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Blain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansheng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Teodorescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,8]]},"reference":[{"key":"46_CR1","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1152\/jappl.1995.78.5.1806","volume":"78","author":"MS Badr","year":"1995","unstructured":"Badr MS, Toiber F, Skatrud JB, Dempsey J (1995) Pharyngeal narrowing\/occlusion during central sleep apnea. J Appl Physiol 78:1806\u20131815","journal-title":"J Appl Physiol"},{"key":"46_CR2","first-page":"R1951","volume":"266","author":"J Bajic","year":"1994","unstructured":"Bajic J, Zuperku EJ, Tonkovic-Capin M, Hopp FA (1994) Interaction between chemoreceptor and stretch receptor inputs at medullary respiratory neurons. Am J Physiol 266:R1951\u2013R1961","journal-title":"Am J Physiol"},{"key":"46_CR3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/jphysiol.1983.sp014906","volume":"343","author":"A Berssenbrugge","year":"1983","unstructured":"Berssenbrugge A, Dempsey J, Iber C, Skatrud J, Wilson P (1983) Mechanisms of hypoxia-induced periodic breathing during sleep in humans. J Physiol 343:507\u2013526","journal-title":"J Physiol"},{"key":"46_CR4","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1152\/japplphysiol.91590.2008","volume":"106","author":"GM Blain","year":"2009","unstructured":"Blain GM, Smith CA, Henderson KS, Dempsey JA (2009) Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog. J Appl Physiol 106:1564\u20131573","journal-title":"J Appl Physiol"},{"key":"46_CR5","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1113\/jphysiol.2010.187211","volume":"588","author":"GM Blain","year":"2010","unstructured":"Blain GM, Smith CA, Henderson KS, Dempsey JA (2010) Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO(2). J Physiol 588:2455\u20132471","journal-title":"J Physiol"},{"key":"46_CR6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1152\/japplphysiol.01617.2005","volume":"101","author":"BJ Chenuel","year":"2006","unstructured":"Chenuel BJ, Smith CA, Skatrud JB, Henderson KS, Dempsey JA (2006) Increased propensity for apnea in response to acute elevations in left atrial pressure during sleep in the dog. J Appl Physiol 101:76\u201383","journal-title":"J Appl Physiol"},{"key":"46_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1113\/expphysiol.2005.032268","volume":"91","author":"NS Cherniack","year":"2006","unstructured":"Cherniack NS, Longobardo GS (2006) Mathematical models of periodic breathing and their usefulness in understanding cardiovascular and respiratory disorders. Exp Physiol 91:295\u2013305","journal-title":"Exp Physiol"},{"key":"46_CR8","doi-asserted-by":"publisher","first-page":"e239","DOI":"10.1371\/journal.pmed.0040239","volume":"4","author":"A Dahan","year":"2007","unstructured":"Dahan A, Nieuwenhuijs D, Teppema L (2007) Plasticity of central chemoreceptors: effect of bilateral carotid body resection on central CO2 sensitivity. PLoS Med 4:e239","journal-title":"PLoS Med"},{"key":"46_CR9","doi-asserted-by":"publisher","first-page":"6635","DOI":"10.1242\/dev.00866","volume":"130","author":"S Dauger","year":"2003","unstructured":"Dauger S, Pattyn A, Lofaso F, Gaultier C, Goridis C, Gallego J, Brunet JF (2003) Phox2b Controls the development of peripheral chemoreceptors and afferent visceral pathways. Development 130:6635\u20136642","journal-title":"Development"},{"key":"46_CR10","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1113\/jphysiol.2008.160689","volume":"587","author":"TA Day","year":"2009","unstructured":"Day TA, Wilson RJ (2009) A negative interaction between brainstem and peripheral respiratory chemoreceptors modulates peripheral chemoreflex magnitude. J Physiol 587:883\u2013896","journal-title":"J Physiol"},{"key":"46_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1152\/physrev.00043.2008","volume":"90","author":"JA Dempsey","year":"2010","unstructured":"Dempsey JA, Veasey SC, Morgan BJ, O\u2019Donnell CP (2010) Pathophysiology of sleep apnea. Physiol Rev 90:47\u2013112","journal-title":"Physiol Rev"},{"key":"46_CR12","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1152\/japplphysiol.01011.2004","volume":"98","author":"MR Hodges","year":"2005","unstructured":"Hodges MR, Opansky C, Qian B, Davis S, Bonis JM, Krause K, Pan LG, Forster HV (2005) Carotid body denervation alters ventilatory responses to ibotenic acid injections or focal acidosis in the medullary raphe. J Appl Physiol 98:1234\u20131242","journal-title":"J Appl Physiol"},{"key":"46_CR13","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1378\/chest.123.2.322","volume":"123","author":"S Javaheri","year":"2003","unstructured":"Javaheri S (2003) Pembrey\u2019s Dream: the time has come for a long-term trial of nocturnal supplemental nasal oxygen to treat central sleep apnea in congestive heart failure. Chest 123:322\u2013325","journal-title":"Chest"},{"key":"46_CR14","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1164\/rccm.200507-1035OC","volume":"173","author":"S Javaheri","year":"2006","unstructured":"Javaheri S (2006) Acetazolamide improves central sleep apnea in heart failure: a double-blind, prospective study. Am J Respir Crit Care Med 173:234\u2013237","journal-title":"Am J Respir Crit Care Med"},{"issue":"21","key":"46_CR15","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1161\/01.CIR.97.21.2154","volume":"97","author":"S Javaheri","year":"1998","unstructured":"Javaheri S, Parker TJ, Liming JD, Corbett WS, Nishiyama H, Wexler L, Roselle GA (1998) Sleep apnea in 81 ambulatory male patients with stable heart failure types and their prevalences, consequences, and presentations. Circulation 97(21):2154\u20132159","journal-title":"Circulation"},{"key":"46_CR16","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1378\/chest.123.5.1551","volume":"123","author":"RN Khayat","year":"2003","unstructured":"Khayat RN, Xie A, Patel AK, Kaminski A, Skatrud JB (2003) Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apnea. Chest 123:1551\u20131560","journal-title":"Chest"},{"key":"46_CR17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1152\/jappl.1982.53.3.644","volume":"53","author":"MC Khoo","year":"1982","unstructured":"Khoo MC, Kronauer RE, Strohl KP, Slutsky AS (1982) Factors inducing periodic breathing in humans: a general model. J Appl Physiol 53:644\u2013659","journal-title":"J Appl Physiol"},{"key":"46_CR18","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1164\/rccm.2110041","volume":"165","author":"H Nakayama","year":"2002","unstructured":"Nakayama H, Smith CA, Rodman JR, Skatrud JB, Dempsey JA (2002) Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep. Am J Respir Crit Care Med 165:1251\u20131260","journal-title":"Am J Respir Crit Care Med"},{"key":"46_CR19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/japplphysiol.00722.2002","volume":"94","author":"H Nakayama","year":"2003","unstructured":"Nakayama H, Smith CA, Rodman JR, Skatrud JB, Dempsey JA (2003) Carotid body denervation eliminates apnea in response to transient hypocapnia. J Appl Physiol 94:155\u2013164","journal-title":"J Appl Physiol"},{"key":"46_CR20","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1161\/hc3101.093699","volume":"104","author":"P Ponikowski","year":"2001","unstructured":"Ponikowski P, Chua TP, Anker SD, Francis DP, Doehner W, Banasiak W, Poole-Wilson PA, Piepoli MF, Coats AJ (2001) Peripheral chemoreceptor hypersensitivity: an ominous sign in patients with chronic heart failure. Circulation 104:544\u2013549","journal-title":"Circulation"},{"key":"46_CR21","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1152\/japplphysiol.00258.2003","volume":"95","author":"JR Rodman","year":"2003","unstructured":"Rodman JR, Henderson KS, Smith CA, Dempsey JA (2003) Cardiovascular effects of the respiratory muscle metaboreflexes in dogs: rest and exercise. J Appl Physiol 95:1159\u20131169","journal-title":"J Appl Physiol"},{"key":"46_CR22","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/jappl.1995.79.3.689","volume":"79","author":"CA Smith","year":"1995","unstructured":"Smith CA, Saupe KW, Henderson KS, Dempsey JA (1995) Ventilatory effects of specific carotid body hypocapnia in dogs during wakefulness and sleep. J Appl Physiol 79:689\u2013699","journal-title":"J Appl Physiol"},{"key":"46_CR23","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1152\/japplphysiol.00017.2007","volume":"103","author":"CA Smith","year":"2007","unstructured":"Smith CA, Chenuel BJ, Henderson KS, Dempsey JA (2007) The apneic threshold during non-REM sleep in dogs: sensitivity of carotid body vs. Central chemoreceptors. J Appl Physiol 103:578\u2013586","journal-title":"J Appl Physiol"},{"key":"46_CR24","doi-asserted-by":"publisher","first-page":"10305","DOI":"10.1523\/JNEUROSCI.2917-06.2006","volume":"26","author":"RL Stornetta","year":"2006","unstructured":"Stornetta RL, Moreira TS, Takakura AC, Kang BJ, Chang DA, West GH, Brunet JF, Mulkey DK, Bayliss DA, Guyenet PG (2006) Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. J Neurosci 26:10305\u201310314","journal-title":"J Neurosci"},{"key":"46_CR25","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1063\/1.370881","volume":"86","author":"SY Sun","year":"1999","unstructured":"Sun SY, Wang W, Zucker IH, Schultz HD (1999) Enhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide. J Appl Physiol 86:1273\u20131282","journal-title":"J Appl Physiol"},{"key":"46_CR26","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1113\/jphysiol.2005.103788","volume":"572","author":"AC Takakura","year":"2006","unstructured":"Takakura AC, Moreira TS, Colombari E, West GH, Stornetta RL, Guyenet PG (2006) Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats. J Physiol 572:503\u2013523","journal-title":"J Physiol"},{"key":"46_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.resp.2008.05.019","volume":"162","author":"A Wellman","year":"2008","unstructured":"Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP (2008) Effect of oxygen in obstructive sleep apnea: role of loop gain. Respir Physiol Neurobiol 162:144\u2013151","journal-title":"Respir Physiol Neurobiol"},{"key":"46_CR28","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1152\/jappl.1997.82.3.918","volume":"82","author":"A Xie","year":"1997","unstructured":"Xie A, Rankin F, Rutherford R, Bradley TD (1997) Effects of inhaled CO2 and added dead space on idiopathic central sleep apnea. J Appl Physiol 82:918\u2013926","journal-title":"J Appl Physiol"},{"key":"46_CR29","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1469-7793.2001.00269.x","volume":"535","author":"A Xie","year":"2001","unstructured":"Xie A, Skatrud JB, Dempsey JA (2001) Effect of hypoxia on the hypopnoeic and apnoeic threshold for CO(2) in sleeping humans. J Physiol 535:269\u2013278","journal-title":"J Physiol"},{"key":"46_CR30","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1152\/japplphysiol.90914.2008","volume":"106","author":"A Xie","year":"2009","unstructured":"Xie A, Skatrud JB, Barczi SR, Reichmuth K, Morgan BJ, Mont S, Dempsey JA (2009) Influence of cerebral blood flow on breathing stability. J Appl Physiol 106:850\u2013856","journal-title":"J Appl Physiol"},{"key":"46_CR31","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1152\/japplphysiol.90408.2008","volume":"105","author":"M Younes","year":"2008","unstructured":"Younes M (2008) Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. J Appl Physiol 105:1389\u20131405","journal-title":"J Appl Physiol"}],"container-title":["Advances in Experimental Medicine and Biology","Arterial Chemoreception"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-007-4584-1_46","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T15:41:42Z","timestamp":1676648502000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-94-007-4584-1_46"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9789400745834","9789400745841"],"references-count":31,"URL":"https:\/\/doi.org\/10.1007\/978-94-007-4584-1_46","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"8 August 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}