{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:26:44Z","timestamp":1793053604931,"version":"4.5.0"},"publisher-location":"Dordrecht","reference-count":425,"publisher":"Springer Netherlands","isbn-type":[{"value":"9789400750241","type":"print"},{"value":"9789400750258","type":"electronic"}],"license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/978-94-007-5025-8_12","type":"book-chapter","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T18:44:08Z","timestamp":1350672248000},"page":"247-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inositol Polyphosphate Phosphatases in Human Disease"],"prefix":"10.1007","author":[{"given":"Sandra","family":"Hakim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micka C.","family":"Bertucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Conduit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Vuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,20]]},"reference":[{"key":"12_CR1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.bbrc.2006.10.169","volume":"351","author":"T Adayev","year":"2006","unstructured":"Adayev T, Chen-Hwang M-C, Murakami N, Wang R, Hwang Y-W (2006) MNB\/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins. Biochem Biophys Res Commun 351:1060\u20131065","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/humu.9239","volume":"23","author":"M Addis","year":"2004","unstructured":"Addis M, Loi M, Lepiani C, Cau M, Melis MA (2004) OCRL mutation analysis in Italian patients with Lowe syndrome. Hum Mutat 23:524\u2013525","journal-title":"Hum Mutat"},{"key":"12_CR3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejmg.2006.10.003","volume":"50","author":"M Addis","year":"2007","unstructured":"Addis M, Meloni C, Congiu R, Santaniello S, Emma F, Zuffardi O, Ciccone R, Cao A, Melis MA, Cau M (2007) A novel interstitial deletion in Xq25, identified by array-CGH in a patient with Lowe syndrome. Eur J Med Genet 50:79\u201384","journal-title":"Eur J Med Genet"},{"key":"12_CR4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.18632\/oncotarget.260","volume":"2","author":"IU Agoulnik","year":"2011","unstructured":"Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM (2011) INPP4B: the new kid on the PI3K block. Oncotarget 2:321\u2013328","journal-title":"Oncotarget"},{"key":"12_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00141.2009","volume":"40","author":"A Agrawal","year":"2009","unstructured":"Agrawal A, Sinha A, Ahmad T, Aich J, Singh P, Sharma A, Ghosh B (2009) Maladaptation of critical cellular functions in asthma: bioinformatic analysis. Physiol Genomics 40:1\u20137","journal-title":"Physiol Genomics"},{"key":"12_CR6","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1182\/blood-2005-05-1841","volume":"107","author":"J Ai","year":"2006","unstructured":"Ai J, Maturu A, Johnson W, Wang Y, Marsh CB, Tridandapani S (2006) The inositol phosphatase SHIP-2 down-regulates Fc\u03b3R-mediated phagocytosis in murine macrophages independently of SHIP-1. Blood 107:813\u2013820","journal-title":"Blood"},{"key":"12_CR7","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1128\/iai.61.5.1707-1714.1993","volume":"61","author":"A Allaoui","year":"1993","unstructured":"Allaoui A, Menard R, Sansonetti PJ, Parsot C (1993) Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus. Infect Immun 61:1707\u20131714","journal-title":"Infect Immun"},{"key":"12_CR8","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.4049\/jimmunol.0903170","volume":"184","author":"F Antignano","year":"2010","unstructured":"Antignano F, Ibaraki M, Kim C, Ruschmann J, Zhang A, Helgason CD, Krystal G (2010) SHIP is required for dendritic cell maturation. J Immunol 184:2805\u20132813","journal-title":"J Immunol"},{"key":"12_CR9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1083\/jcb.200609017","volume":"177","author":"K Aoki","year":"2007","unstructured":"Aoki K, Nakamura T, Inoue T, Meyer T, Matsuda M (2007) An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol 177:817\u2013827","journal-title":"J Cell Biol"},{"key":"12_CR10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0387-7604(01)00405-3","volume":"24","author":"Y Arai","year":"2002","unstructured":"Arai Y, Ijuin T, Takenawa T, Becker LE, Takashima S (2002) Excessive expression of synaptojanin in brains with down syndrome. Brain Dev 24:67\u201372","journal-title":"Brain Dev"},{"issue":"26","key":"12_CR11","doi-asserted-by":"crossref","first-page":"23407","DOI":"10.1074\/jbc.M110.214247","volume":"286","author":"MV Astle","year":"2011","unstructured":"Astle MV, Ooms LM, Cole AR, Binge LC, Dyson JM, Layton MJ, Petratos S, Sutherland C, Mitchell CA (2011) Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP): collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation. J Biol Chem 286(26):23407\u201323418","journal-title":"J Biol Chem"},{"key":"12_CR12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/358239a0","volume":"358","author":"O Attree","year":"1992","unstructured":"Attree O, Olivos IM, Okabe I, Bailey LC, Nelson DL, Lewis RA, McLnnes RR, Nussbaum RL (1992) The Lowe\u2019s oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase. Nature 358:239\u2013242","journal-title":"Nature"},{"key":"12_CR13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0065-2571(02)00043-2","volume":"43","author":"K Backers","year":"2003","unstructured":"Backers K, Blero D, Paternotte N, Zhang J, Erneux C (2003) The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases. Adv Enzyme Regul 43:15\u201328","journal-title":"Adv Enzyme Regul"},{"key":"12_CR14","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.cub.2009.08.045","volume":"19","author":"Y-K Bae","year":"2009","unstructured":"Bae Y-K, Kim E, L\u2019Hernault SW, Barr MM (2009) The CIL-1 PI 5-phosphatase localizes TRP polycystins to cilia and activates sperm in C. elegans. Curr Biol 19:1599\u20131607","journal-title":"Curr Biol"},{"key":"12_CR15","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1101\/gad.1932810","volume":"24","author":"L Bai","year":"2010","unstructured":"Bai L, Rohrschneider LR (2010) s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue. Genes Dev 24:1882\u20131892","journal-title":"Genes Dev"},{"key":"12_CR16","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ni.f.209","volume":"9","author":"D Baltimore","year":"2008","unstructured":"Baltimore D, Boldin MP, O\u2019Connell RM, Rao DS, Taganov KD (2008) MicroRNAs: new regulators of immune cell development and function. Nat Immunol 9:839\u2013845","journal-title":"Nat Immunol"},{"key":"12_CR17","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/S0021-9258(19)40089-6","volume":"265","author":"VS Bansal","year":"1990","unstructured":"Bansal VS, Caldwell KK, Majerus PW (1990) The isolation and characterization of inositol polyphosphate 4-phosphatase. J Biol Chem 265:1806\u20131811","journal-title":"J Biol Chem"},{"key":"12_CR18","doi-asserted-by":"crossref","first-page":"9444","DOI":"10.1016\/S0021-9258(18)47953-7","volume":"262","author":"VS Bansal","year":"1987","unstructured":"Bansal VS, Inhorn RC, Majerus PW (1987) The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate. J Biol Chem 262:9444\u20139447","journal-title":"J Biol Chem"},{"key":"12_CR19","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/sj.onc.1209187","volume":"25","author":"S Barnache","year":"2006","unstructured":"Barnache S, Le Scolan E, Kosmider O, Denis N, Moreau-Gachelin F (2006) Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Oncogene 25:1420\u20131423","journal-title":"Oncogene"},{"key":"12_CR20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/BJ20070558","volume":"407","author":"IH Batty","year":"2007","unstructured":"Batty IH, van\u00c2 der\u00c2 kaay J, Gray A, Telfer JF, Dixon MJ, Downes CP (2007) The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology two domain containing inositol polyphosphate 5-phosphatase 2, SHIP2. Biochem J 407:255\u2013266","journal-title":"Biochem J"},{"key":"12_CR21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.cub.2011.05.030","volume":"21","author":"K Ben El Kadhi","year":"2011","unstructured":"Ben El Kadhi K, Roubinet C, Solinet S, Emery G, Carr\u00e9no S (2011) The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis. Curr Biol 21:1074\u20131079","journal-title":"Curr Biol"},{"key":"12_CR22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/gcc.20128","volume":"42","author":"M Benetkiewicz","year":"2005","unstructured":"Benetkiewicz M, Wang Y, Schaner M, Wang P, Mantripragada KK, Buckley PG, Kristensen G, B\u00f8rresen-Dale A-L, Dumanski JP (2005) High-resolution gene copy number and expression profiling of human chromosome 22 in ovarian carcinomas. Genes Chromosom Cancer 42:228\u2013237","journal-title":"Genes Chromosom Cancer"},{"key":"12_CR23","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1210\/en.2006-0280","volume":"147","author":"DF Bertelli","year":"2006","unstructured":"Bertelli DF, Araujo EP, Cesquini M, Stoppa GR, Gasparotto-Contessotto M, Toyama MH, Felix JVC, Carvalheira JB, Michelini LC, Chiavegatto S, Boschero AC, Saad MJA, Lopes-Cendes I, Velloso LA (2006) Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight. Endocrinology 147:5385\u20135399","journal-title":"Endocrinology"},{"key":"12_CR24","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/ng.423","volume":"41","author":"SL Bielas","year":"2009","unstructured":"Bielas SL, Silhavy JL, Brancati F, Kisseleva MV, AL-Gazali L, Sztriha L, Bayoumi RA, Zaki MS, Abdel-Aleem A, Rosti RO, Kayserili H, Swistun D, Scott LC, Bertini E, Boltshauser E, Fazzi E, Travaglini L, Field SJ, Gayral S, Jacoby M, Schurmans S, Dallapiccola B, Majerus PW, Valente EM, Gleeson JG (2009) Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet 41:1032\u20131036","journal-title":"Nat Genet"},{"key":"12_CR25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ejmg.2007.03.004","volume":"50","author":"A-M Bisgaard","year":"2007","unstructured":"Bisgaard A-M, Kirchhoff M, Nielsen JE, Brandt C, Hove H, Jepsen B, Jensen T, Ullmann R, Skovby F (2007) Transmitted cytogenetic abnormalities in patients with mental retardation: pathogenic or normal variants? Eur J Med Genet 50:243\u2013255","journal-title":"Eur J Med Genet"},{"key":"12_CR26","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1128\/IAI.01596-07","volume":"76","author":"JL Bishop","year":"2008","unstructured":"Bishop JL, Sly LM, Krystal G, Finlay BB (2008) The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo. Infect Immun 76:2913\u20132922","journal-title":"Infect Immun"},{"key":"12_CR27","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1083\/jcb.200708109","volume":"180","author":"A Blagoveshchenskaya","year":"2008","unstructured":"Blagoveshchenskaya A, Cheong FY, Rohde HM, Glover G, Kn\u00f6dler A, Nicolson T, Boehmelt G, Mayinger P (2008) Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J Cell Biol 180:803\u2013812","journal-title":"J Cell Biol"},{"key":"12_CR28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1006\/bbrc.2001.4639","volume":"282","author":"D Blero","year":"2001","unstructured":"Blero D, De Smedt F, Pesesse X, Paternotte N, Moreau C, Payrastre B, Erneux C (2001) The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin. Biochem Biophys Res Commun 282:839\u2013843","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR29","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.201004005","volume":"191","author":"M Bohdanowicz","year":"2010","unstructured":"Bohdanowicz M, Cos\u00edo G, Backer JM, Grinstein S (2010) Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes. J Cell Biol 191:999\u20131012","journal-title":"J Cell Biol"},{"key":"12_CR30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jpeds.2009.01.049","volume":"155","author":"A B\u00f6kenkamp","year":"2009","unstructured":"B\u00f6kenkamp A, B\u00f6ckenhauer D, Cheong HI, Hoppe B, Tasic V, Unwin R, Ludwig M (2009) Dent-2 disease: a mild variant of Lowe syndrome. J Pediatr 155:94\u201399","journal-title":"J Pediatr"},{"key":"12_CR31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1681\/ASN.2010050565","volume":"22","author":"SP Bothwell","year":"2011","unstructured":"Bothwell SP, Chan E, Bernardini IM, Kuo Y-M, Gahl WA, Nussbaum RL (2011) Mouse model for Lowe syndrome\/dent disease two renal tubulopathy. J Am Soc Nephrol 22:443\u2013448","journal-title":"J Am Soc Nephrol"},{"key":"12_CR32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","volume":"423","author":"WJ Boyle","year":"2003","unstructured":"Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423:337\u2013342","journal-title":"Nature"},{"key":"12_CR33","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.4049\/jimmunol.178.6.3353","volume":"178","author":"A Brauweiler","year":"2007","unstructured":"Brauweiler A, Merrell K, Gauld SB, Cambier JC (2007) Cutting edge: acute and chronic exposure of immature B cells to antigen leads to impaired homing and SHIP1-dependent reduction in stromal cell-derived factor-1 responsiveness. J Immunol 178:3353\u20133357","journal-title":"J Immunol"},{"key":"12_CR34","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.191.9.1545","volume":"191","author":"A Brauweiler","year":"2000","unstructured":"Brauweiler A, Tamir I, Dal Porto J, Benschop RJ, Helgason CD, Humphries RK, Freed JH, Cambier JC (2000) Differential regulation of B cell development, activation, and death by the Src homology 2 domain-containing 5\u2019 inositol phosphatase (ship). J Exp Med 191:1545\u20131554","journal-title":"J Exp Med"},{"key":"12_CR35","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/jmg.2009.069906","volume":"47","author":"DL Bruno","year":"2010","unstructured":"Bruno DL, Anderlid B-M, Lindstrand A, van Ravenswaaij-Arts C, Ganesamoorthy D, Lundin J, Martin CL, Douglas J, Nowak C, Adam MP, Kooy RF, Van der Aa N, Reyniers E, Vandeweyer G, Stolte-Dijkstra I, Dijkhuizen T, Yeung A, Delatycki M, Borgstr\u00f6m B, Thelin L, Cardoso C, van Bon B, Pfundt R, de Vries BBA, Wallin A, Amor DJ, James PA, Slater HR, Schoumans J (2010) Further molecular and clinical delineation of co-locating 17p13.3 microdeletions and microduplications that show distinctive phenotypes. J Med Genet 47:299\u2013311","journal-title":"J Med Genet"},{"key":"12_CR36","doi-asserted-by":"crossref","first-page":"E1871","DOI":"10.1152\/ajpendo.00263.2006","volume":"292","author":"R Buettner","year":"2007","unstructured":"Buettner R, Ottinger I, Gerhardt-Salbert C, Wrede CE, Scholmerich J, Bollheimer LC (2007) Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome. Am J Physiol Endocrionol Metab 292:E1871\u2013E1878","journal-title":"Am J Physiol Endocrionol Metab"},{"key":"12_CR37","doi-asserted-by":"crossref","first-page":"15363","DOI":"10.1021\/bi9708085","volume":"36","author":"JK Campbell","year":"1997","unstructured":"Campbell JK, Gurung R, Romero S, Speed CJ, Andrews RK, Berndt MC, Mitchell CA (1997) Activation of the 43\u00a0kDa inositol polyphosphate 5-phosphatase by 14\u20133-3\u03b6. Biochemistry 36:15363\u201315370","journal-title":"Biochemistry"},{"key":"12_CR38","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1086\/374320","volume":"72","author":"C Cardoso","year":"2003","unstructured":"Cardoso C, Leventer RJ, Ward HL, Toyo-oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (2003) Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller\u2013Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3. Am J Hum Genet 72:918\u2013930","journal-title":"Am J Hum Genet"},{"key":"12_CR39","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.4049\/jimmunol.1001034","volume":"186","author":"C Cekic","year":"2011","unstructured":"Cekic C, Casella CR, Sag D, Antignano F, Kolb J, Suttles J, Hughes MR, Krystal G, Mitchell TC (2011) MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4. J Immunol 186:3858\u20133865","journal-title":"J Immunol"},{"key":"12_CR40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.pathol.4.110807.092311","volume":"4","author":"N Chalhoub","year":"2009","unstructured":"Chalhoub N, Baker SJ (2009) PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4:127\u2013150","journal-title":"Annu Rev Pathol"},{"key":"12_CR41","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.devcel.2010.12.008","volume":"20","author":"B Chang-Ileto","year":"2011","unstructured":"Chang-Ileto B, Frere SG, Chan RB, Voronov SV, Roux AL, Di Paolo G (2011) Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission. Dev Cell 20:206\u2013218","journal-title":"Dev Cell"},{"key":"12_CR42","doi-asserted-by":"crossref","first-page":"17117","DOI":"10.1073\/pnas.0904397106","volume":"106","author":"KT Chang","year":"2009","unstructured":"Chang KT, Min K-T (2009) Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for down syndrome. Proc Natl Acad Sci U S A 106:17117\u201317122","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR43","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1158\/1078-0432.CCR-07-1658","volume":"14","author":"MCU Cheang","year":"2008","unstructured":"Cheang MCU, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK, Perou CM, Nielsen TO (2008) Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res 14:1368\u20131376","journal-title":"Clin Cancer Res"},{"key":"12_CR44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00726-002-0340-6","volume":"24","author":"MS Cheon","year":"2003","unstructured":"Cheon MS, Kim SH, Ovod V, Kopitar Jerala N, Morgan JI, Hatefi Y, Ijuin T, Takenawa T, Lubec G (2003) Protein levels of genes encoded on chromosome 21 in fetal down syndrome brain: challenging the gene dosage effect hypothesis (Part III). Amino Acids 24:127\u2013134","journal-title":"Amino Acids"},{"key":"12_CR45","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1600-0854.2010.01092.x","volume":"11","author":"FY Cheong","year":"2010","unstructured":"Cheong FY, Sharma V, Blagoveshchenskaya A, Oorschot VMJ, Brankatschk B, Klumperman J, Freeze HH, Mayinger P (2010) Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity. Traffic 11:1180\u20131190","journal-title":"Traffic"},{"key":"12_CR46","doi-asserted-by":"crossref","first-page":"44987","DOI":"10.1074\/jbc.M406416200","volume":"279","author":"Y Chi","year":"2004","unstructured":"Chi Y, Zhou B, Wang WQ, Chung SK, Kwon YU, Ahn YH, Chang YT, Tsujishita Y, Hurley JH, Zhang ZY (2004) Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe synaptojanin and SHIP2. J Biol Chem 279:44987\u201344995","journal-title":"J Biol Chem"},{"key":"12_CR47","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1091\/mbc.e05-02-0120","volume":"16","author":"R Choudhury","year":"2005","unstructured":"Choudhury R, Diao A, Zhang F, Eisenberg E, Saint-Pol A, Williams C, Konstantakopoulos A, Lucocq J, Johannes L, Rabouille C, Greene LE, Lowe M (2005) Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network. Mol Biol Cell 16:3467\u20133479","journal-title":"Mol Biol Cell"},{"key":"12_CR48","doi-asserted-by":"crossref","first-page":"9965","DOI":"10.1074\/jbc.M807442200","volume":"284","author":"R Choudhury","year":"2009","unstructured":"Choudhury R, Noakes CJ, McKenzie E, Kox C, Lowe M (2009) Differential clathrin binding and subcellular localization of OCRL1 splice isoforms. J Biol Chem 284:9965\u20139973","journal-title":"J Biol Chem"},{"key":"12_CR49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature05876","volume":"448","author":"CY Chow","year":"2007","unstructured":"Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler MH (2007) Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448:68\u201372","journal-title":"Nature"},{"key":"12_CR50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.phrs.2005.09.001","volume":"53","author":"KU Chow","year":"2006","unstructured":"Chow KU, Nowak D, Kim S-Z, Schneider B, Komor M, Boehrer S, Mitrou PS, Hoelzer D, Weidmann E, Hofmann W-K (2006) In vivo drug-response in patients with leukemic non-Hodgkin\u2019s lymphomas is associated with in vitro chemosensitivity and gene expression profiling. Pharmacol Res 53:49\u201361","journal-title":"Pharmacol Res"},{"key":"12_CR51","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1158\/0008-5472.CAN-04-2097","volume":"64","author":"YY Chuang","year":"2004","unstructured":"Chuang YY, Tran NL, Rusk N, Nakada M, Berens ME, Symons M (2004) Role of synaptojanin 2 in Glioma cell migration and invasion. Cancer Res 64:8271\u20138275","journal-title":"Cancer Res"},{"key":"12_CR52","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/35051094","volume":"409","author":"S Clement","year":"2001","unstructured":"Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S (2001) The lipid phosphatase SHIP2 controls insulin sensitivity. Nature 409:92\u201397","journal-title":"Nature"},{"key":"12_CR53","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/iai.55.3.521-527.1987","volume":"55","author":"PL Clerc","year":"1987","unstructured":"Clerc PL, Ryter A, Mounier J, Sansonetti PJ (1987) Plasmid-mediated early killing of eucaryotic cells by Shigella flexneri as studied by infection of J774 macrophages. Infect Immun 55:521\u2013527","journal-title":"Infect Immun"},{"key":"12_CR54","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1083\/jcb.109.6.2939","volume":"109","author":"AE Cleves","year":"1989","unstructured":"Cleves AE, Novick PJ, Bankaitis VA (1989) Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. J Cell Biol 109:2939\u20132950","journal-title":"J Cell Biol"},{"key":"12_CR55","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1182\/blood-2008-09-181164","volume":"113","author":"MM Collazo","year":"2009","unstructured":"Collazo MM, Wood D, Paraiso KHT, Lund E, Engelman RW, Le C-T, Stauch D, Kotsch K, Kerr WG (2009) SHIP limits immunoregulatory capacity in the T-cell compartment. Blood 113:2934\u20132944","journal-title":"Blood"},{"key":"12_CR56","doi-asserted-by":"crossref","first-page":"e22260","DOI":"10.1371\/journal.pone.0022260","volume":"6","author":"KG Cooper","year":"2011","unstructured":"Cooper KG, Winfree S, Malik-Kale P, Jolly C, Ireland R, Knodler LA, Steele-Mortimer O (2011) Activation of Akt by the bacterial inositol phosphatase, SopB, is Wortmannin insensitive. PLoS ONE 6:e22260","journal-title":"PLoS ONE"},{"key":"12_CR57","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1086\/302206","volume":"64","author":"B Cormand","year":"1999","unstructured":"Cormand B, Avela K, Pihko H, Santavuori P, Talim B, Topaloglu H, de la Chapelle A, Lehesjoki A-E (1999) Assignment of the muscle\u2013eye\u2013brain disease gene to 1p32\u2013p34 by linkage analysis and homozygosity mapping. Am J Hum Genet 64:126\u2013135","journal-title":"Am J Hum Genet"},{"key":"12_CR58","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1182\/blood-2009-05-220814","volume":"114","author":"S Costinean","year":"2009","unstructured":"Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM (2009) Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood 114:1374\u20131382","journal-title":"Blood"},{"key":"12_CR59","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1084\/jem.193.1.61","volume":"193","author":"D Cox","year":"2001","unstructured":"Cox D, Dale BM, Kashiwada M, Helgason CD, Greenberg S (2001) A regulatory role for Src homology 2 domain-containing inositol 5\u2019-phosphatase (SHIP) in phagocytosis mediated by Fc\u03b3 receptors and complement receptor 3 (\u03b1M\u03b22;CD11b\/CD18). J Exp Med 193:61\u201371","journal-title":"J Exp Med"},{"key":"12_CR60","doi-asserted-by":"crossref","first-page":"e8508","DOI":"10.1371\/journal.pone.0008508","volume":"4","author":"TJ Cremer","year":"2009","unstructured":"Cremer TJ, Ravneberg DH, Clay CD, Piper-Hunter MG, Marsh CB, Elton TS, Gunn JS, Amer A, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani S (2009) MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS ONE 4:e8508","journal-title":"PLoS ONE"},{"key":"12_CR61","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0092-8674(00)81649-9","volume":"99","author":"O Cremona","year":"1999","unstructured":"Cremona O, Di Paolo G, Wenk MR, L\u00fcthi A, Kim WT, Takei K, Daniell L, Nemoto Y, Shears SB, Flavell RA, McCormick DA, De Camilli P (1999) Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 99:179\u2013188","journal-title":"Cell"},{"key":"12_CR62","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood-2008-02-138651","volume":"113","author":"JE Crowley","year":"2009","unstructured":"Crowley JE, Stadanlick JE, Cambier JC, Cancro MP (2009) Fc\u03b3RII\u03b2 signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood 113:1464\u20131473","journal-title":"Blood"},{"key":"12_CR63","doi-asserted-by":"crossref","first-page":"F335","DOI":"10.1152\/ajprenal.00453.2009","volume":"298","author":"S Cui","year":"2010","unstructured":"Cui S, Guerriero CJ, Szalinski CM, Kinlough CL, Hughey RP, Weisz OA (2010) OCRL1 function in renal epithelial membrane traffic. Am J Physiol Ren Physiol 298:F335\u2013F345","journal-title":"Am J Physiol Ren Physiol"},{"key":"12_CR64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1755-8417-2-3","volume":"2","author":"A D\u2019Angelo","year":"2009","unstructured":"D\u2019Angelo A, Franco B (2009) The dynamic cilium in human diseases. PathoGenetics 2:3","journal-title":"PathoGenetics"},{"key":"12_CR65","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ncb2279","volume":"13","author":"D Dambournet","year":"2011","unstructured":"Dambournet D, Machicoane M, Chesneau L, Sachse M, Rocancourt M, El Marjou A, Formstecher E, Salomon R, Goud B, Echard A (2011) Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis. Nat Cell Biol 13:981\u2013988","journal-title":"Nat Cell Biol"},{"key":"12_CR66","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.1074\/jbc.272.13.8710","volume":"272","author":"E De Heuvel","year":"1997","unstructured":"De Heuvel E, Bell AW, Ramjaun AR, Wong K, Sossin WS, McPherson PS (1997) Identification of the major synaptojanin-binding proteins in brain. J Biol Chem 272:8710\u20138716","journal-title":"J Biol Chem"},{"key":"12_CR67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0014-5793(94)00509-5","volume":"347","author":"F De Smedt","year":"1994","unstructured":"De Smedt F, Verjans B, Mailleux P, Erneux C (1994) Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells. FEBS Lett 347:69\u201372","journal-title":"FEBS Lett"},{"key":"12_CR68","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-2184.2011.00743.x","volume":"44","author":"X Deng","year":"2011","unstructured":"Deng X, Feng C, Wang EH, Zhu YQ, Cui C, Zong ZH, Li GS, Liu C, Meng J, Yu BZ (2011) Influence of proline-rich inositol polyphosphate 5-phosphatase, on early development of fertilized mouse eggs, via inhibition of phosphorylation of Akt. Cell Prolif 44:156\u2013165","journal-title":"Cell Prolif"},{"key":"12_CR69","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1158\/1541-7786.MCR-09-0068","volume":"7","author":"A Denley","year":"2009","unstructured":"Denley A, Gymnopoulos M, Kang S, Mitchell C, Vogt PK (2009) Requirement of phosphatidylinositol(3,4,5)trisphosphate in phosphatidylinositol 3-kinase-induced oncogenic transformation. Mol Cancer Res 7:1132\u20131138","journal-title":"Mol Cancer Res"},{"key":"12_CR70","volume-title":"Clinical and molecular diagnosis of Miller\u2013Dieker syndrome","author":"WB Dobyns","year":"1991","unstructured":"Dobyns WB, Curry CJR, Hoyme HE, Turlington L, Ledbetter DH (1991) Clinical and molecular diagnosis of Miller\u2013Dieker syndrome. Cell Press, Cambridge"},{"key":"12_CR71","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1084\/jem.20060650","volume":"203","author":"S Dong","year":"2006","unstructured":"Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, Michel F (2006) T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. J Exp Med 203:2509\u20132518","journal-title":"J Exp Med"},{"key":"12_CR72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/002215540004800203","volume":"48","author":"MA Dressman","year":"2000","unstructured":"Dressman MA, Olivos-Glander IM, Nussbaum RL, Suchy SF (2000) Ocrl1, a PtdIns(4,5)P2 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells. J Histochem Cytochem 48:179\u2013189","journal-title":"J Histochem Cytochem"},{"key":"12_CR73","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1128\/EC.5.4.723-731.2006","volume":"5","author":"JE Duex","year":"2006","unstructured":"Duex JE, Nau JJ, Kauffman EJ, Weisman LS (2006a) Phosphoinositide 5-phosphatase Fig4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels. Eukaryot Cell 5:723\u2013731","journal-title":"Eukaryot Cell"},{"key":"12_CR74","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1083\/jcb.200512105","volume":"172","author":"JE Duex","year":"2006","unstructured":"Duex JE, Tang F, Weisman LS (2006b) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI(3,5)P2 synthesis and turnover. J Cell Biol 172:693\u2013704","journal-title":"J Cell Biol"},{"key":"12_CR75","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.biocel.2005.05.003","volume":"37","author":"JM Dyson","year":"2005","unstructured":"Dyson JM, Kong AM, Wiradjaja F, Astle MV, Gurung R, Mitchell CA (2005) The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2. Int J Biochem Cell Biol 37:2260\u20132265","journal-title":"Int J Biochem Cell Biol"},{"key":"12_CR76","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1083\/jcb.200104005","volume":"155","author":"JM Dyson","year":"2001","unstructured":"Dyson JM, O\u2019Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA (2001) The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. J Cell Biol 155:1065\u20131079","journal-title":"J Cell Biol"},{"key":"12_CR77","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.leukres.2008.03.003","volume":"32","author":"J Edelmann","year":"2008","unstructured":"Edelmann J, Klein-Hitpass L, Carpinteiro A, F\u00fchrer A, Sellmann L, Stilgenbauer S, D\u00fchrsen U, D\u00fcrig J (2008) Bone marrow fibroblasts induce expression of PI3K\/NF-\u03baB pathway genes and a pro-angiogenic phenotype in CLL cells. Leuk Res 32:1565\u20131572","journal-title":"Leuk Res"},{"key":"12_CR78","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3507::AID-IMMU3507>3.0.CO;2-9","volume":"29","author":"C Edmunds","year":"1999","unstructured":"Edmunds C, Parry RV, Burgess SJ, Reaves B, Ward SG (1999) CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP. Eur J Immunol 29:3507\u20133515","journal-title":"Eur J Immunol"},{"key":"12_CR79","first-page":"19","volume":"13","author":"CJ Edwards","year":"2007","unstructured":"Edwards CJ, Feldman JL, Beech J, Shields KM, Stover JA, Trepicchio WL, Larsen G, Foxwell BMJ, Brennan FM, Feldmann M, Pittman DD (2007) Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis. Mol Med 13:19","journal-title":"Mol Med"},{"key":"12_CR80","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1158\/1541-7786.MCR-04-0180","volume":"3","author":"RE Ellsworth","year":"2005","unstructured":"Ellsworth RE, Ellsworth DL, Neatrour DM, Deyarmin B, Lubert SM, Sarachine MJ, Brown P, Hooke JA, Shriver CD (2005) Allelic imbalance in primary breast carcinomas and metastatic tumors of the axillary lymph nodes. Mol Cancer Res 3:71\u201377","journal-title":"Mol Cancer Res"},{"key":"12_CR81","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1042\/BJ20110173","volume":"439","author":"Elong Edimo WS","year":"2011","unstructured":"WS Elong Edimo, Derua R, Janssens V, Nakamura T, Vanderwinden JM, Waelkens E, Erneux C (2011) Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability. Biochem J 439:391\u2013401","journal-title":"Biochem J"},{"key":"12_CR82","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/bjc.1994.418","volume":"70","author":"P Englefield","year":"1994","unstructured":"Englefield P, Foulkes WD, Campbell IG (1994) Loss of heterozygosity on chromosome 22 in ovarian carcinoma is distal to and is not accompanied by mutations in NF2 at 22q12. Br J Cancer 70:905\u2013907","journal-title":"Br J Cancer"},{"key":"12_CR83","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.140.3.461","volume":"140","author":"S Erdman","year":"1998","unstructured":"Erdman S, Lin L, Malczynski M, Snyder M (1998) Pheromone-regulated genes required for yeast mating differentiation. J Cell Biol 140:461\u2013483","journal-title":"J Cell Biol"},{"key":"12_CR84","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2007.08.004","volume":"13","author":"KS Erdmann","year":"2007","unstructured":"Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P (2007) A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev Cell 13:377\u2013390","journal-title":"Dev Cell"},{"key":"12_CR85","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1128\/JVI.78.4.1971-1980.2004","volume":"78","author":"SJ Erkeland","year":"2004","unstructured":"Erkeland SJ, Valkhof M, Heijmans-Antonissen C, van Hoven-Beijen A, Delwel R, Hermans MHA, Touw IP (2004) Large-scale identification of disease genes involved in acute myeloid leukemia. J Virol 78:1971\u20131980","journal-title":"J Virol"},{"key":"12_CR86","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/hmg\/ddi153","volume":"14","author":"A Faucherre","year":"2005","unstructured":"Faucherre A, Desbois P, Nagano F, Satre V, Lunardi J, Gacon G, Dorseuil O (2005) Lowe syndrome protein Ocrl1 is translocated to membrane ruffles upon Rac GTPase activation: a new perspective on Lowe syndrome pathophysiology. Hum Mol Genet 14:1441\u20131448","journal-title":"Hum Mol Genet"},{"key":"12_CR87","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1093\/hmg\/ddg250","volume":"12","author":"A Faucherre","year":"2003","unstructured":"Faucherre A, Desbois P, Satre V, Lunardi J, Dorseuil O, Gacon G (2003) Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network. Hum Mol Genet 12:2449\u20132456","journal-title":"Hum Mol Genet"},{"key":"12_CR88","doi-asserted-by":"crossref","first-page":"22231","DOI":"10.1073\/pnas.1015245107","volume":"107","author":"CG Fedele","year":"2010","unstructured":"Fedele CG, Ooms LM, Ho M, Vieusseux J, O\u2019Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JEJ, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA (2010) Inositol polyphosphate 4-phosphatase II regulates PI3K\/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A 107:22231\u201322236","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR89","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1093\/hmg\/ddp460","volume":"18","author":"CJ Ferguson","year":"2009","unstructured":"Ferguson CJ, Lenk GM, Meisler MH (2009) Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Hum Mol Genet 18:4868\u20134878","journal-title":"Hum Mol Genet"},{"key":"12_CR90","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.cmet.2011.08.013","volume":"14","author":"M Ferron","year":"2011","unstructured":"Ferron M, Boudiffa M, Arsenault M, Rached M, Pata M, Giroux S, Elfassihi L, Kisseleva M, Majerus Philip W, Rousseau F, Vacher J (2011) Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab 14:466\u2013477","journal-title":"Cell Metab"},{"key":"12_CR91","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.gene.2006.02.022","volume":"376","author":"M Ferron","year":"2006","unstructured":"Ferron M, Vacher J (2006) Characterization of the murine Inpp 4b gene and identification of a novel isoform. Gene 376:152\u2013161","journal-title":"Gene"},{"key":"12_CR92","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1091\/mbc.12.8.2396","volume":"12","author":"M Foti","year":"2001","unstructured":"Foti M, Audhya A, Emr SD (2001) Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell 12:2396\u20132411","journal-title":"Mol Biol Cell"},{"key":"12_CR93","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.4049\/jimmunol.169.10.5441","volume":"169","author":"RW Freeburn","year":"2002","unstructured":"Freeburn RW, Wright KL, Burgess SJ, Astoul E, Cantrell DA, Ward SG (2002) Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors. J Immunol 169:5441\u20135450","journal-title":"J Immunol"},{"key":"12_CR94","doi-asserted-by":"crossref","first-page":"15213","DOI":"10.1073\/pnas.0507184102","volume":"102","author":"R Fukuda","year":"2005","unstructured":"Fukuda R, Hayashi A, Utsunomiya A, Nukada Y, Fukui R, Itoh K, Tezuka K, Ohashi K, Mizuno K, Sakamoto M, Hamanoue M, Tsuji T (2005) Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia\/lymphoma (ATLL). Proc Natl Acad Sci U S A 102:15213\u201315218","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR95","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1074\/jbc.M806325200","volume":"284","author":"RI Fukuda","year":"2009","unstructured":"Fukuda RI, Tsuchiya K, Suzuki K, Itoh K, Fujita J, Utsunomiya A, Tsuji T (2009) Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway. J Biol Chem 284:2680\u20132689","journal-title":"J Biol Chem"},{"key":"12_CR96","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.2337\/diabetes.54.7.1958","volume":"54","author":"K Fukui","year":"2005","unstructured":"Fukui K, Wada T, Kagawa S, Nagira K, Ikubo M, Ishihara H, Kobayashi M, Sasaoka T (2005) Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5\u2019-phosphatase 2) on insulin signaling and glucose metabolism in mice. Diabetes 54:1958\u20131967","journal-title":"Diabetes"},{"key":"12_CR97","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/gcc.2870070311","volume":"7","author":"D Fults","year":"1993","unstructured":"Fults D, Pedone C (1993) Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme. Genes Chromosom Cancer 7:173\u2013177","journal-title":"Genes Chromosom Cancer"},{"key":"12_CR98","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/eji.201040559","volume":"40","author":"SJ Galli","year":"2010","unstructured":"Galli SJ, Tsai M (2010) Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol 40:1843\u20131851","journal-title":"Eur J Immunol"},{"key":"12_CR99","doi-asserted-by":"crossref","first-page":"e184","DOI":"10.1093\/bioinformatics\/btl230","volume":"22","author":"O Gevaert","year":"2006","unstructured":"Gevaert O, Smet FD, Timmerman D, Moreau Y, Moor BD (2006) Predicting the prognosis of breast cancer by integrating clinical and microarray data with Bayesian networks. Bioinformatics 22:e184\u2013e190","journal-title":"Bioinformatics"},{"key":"12_CR100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ccr.2009.06.006","volume":"16","author":"C Gewinner","year":"2009","unstructured":"Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC (2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16:115\u2013125","journal-title":"Cancer Cell"},{"key":"12_CR101","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.4049\/jimmunol.173.12.7324","volume":"173","author":"T Ghansah","year":"2004","unstructured":"Ghansah T, Paraiso KH, Highfill S, Desponts C, May S, McIntosh JK, Wang JW, Ninos J, Brayer J, Cheng F, Sotomayor E, Kerr WG (2004) Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses. J Immunol 173:7324\u20137330","journal-title":"J Immunol"},{"key":"12_CR102","doi-asserted-by":"crossref","first-page":"26857","DOI":"10.1074\/jbc.272.43.26857","volume":"272","author":"S Giuriato","year":"1997","unstructured":"Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H (1997) Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets. J Biol Chem 272:26857\u201326863","journal-title":"J Biol Chem"},{"key":"12_CR103","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj20030581","volume":"376","author":"S Giuriato","year":"2003","unstructured":"Giuriato S, Pesesse X, Bodin S, Sasaki T, Viala C, Marion E, Penninger J, Schurmans S, Erneux C, Payrastre B (2003) SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J 376:199\u2013207","journal-title":"Biochem J"},{"key":"12_CR104","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.advenzreg.2007.11.004","volume":"48","author":"M-P Gratacap","year":"2008","unstructured":"Gratacap M-P, S\u00e9verin S, Chicanne G, Plantavid M, Payrastre B (2008) Different roles of SHIP1 according to the cell context: the example of blood platelets. Adv Enzyme Regul 48:240\u2013252","journal-title":"Adv Enzyme Regul"},{"key":"12_CR105","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2337\/db06-1660","volume":"56","author":"R Grempler","year":"2007","unstructured":"Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N (2007) Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis. Diabetes 56:2235\u20132241","journal-title":"Diabetes"},{"key":"12_CR106","first-page":"5979","volume":"61","author":"S Gruvberger","year":"2001","unstructured":"Gruvberger S, Ringn\u00e9r M, Chen Y, Panavally S, Saal LH, Borg \u00c5, Fern\u00f6 M, Peterson C, Meltzer PS (2001) Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res 61:5979\u20135984","journal-title":"Cancer Res"},{"key":"12_CR107","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.20.100301.064828","volume":"20","author":"P Guermonprez","year":"2002","unstructured":"Guermonprez P, Valladeau J, Zitvogel L, Th\u00e9ry C, Amigorena S (2002) Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 20:621\u2013667","journal-title":"Annu Rev Immunol"},{"key":"12_CR108","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.febslet.2010.04.051","volume":"584","author":"G Guittard","year":"2010","unstructured":"Guittard G, Mortier E, Tronch\u00e8re H, Firaguay G, G\u00e9rard A, Zimmermann P, Payrastre B, Nun\u00e8s JA (2010) Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways. FEBS Lett 584:2455\u20132460","journal-title":"FEBS Lett"},{"key":"12_CR109","doi-asserted-by":"crossref","first-page":"12990","DOI":"10.1074\/jbc.274.19.12990","volume":"274","author":"S Guo","year":"1999","unstructured":"Guo S, Stolz LE, Lemrow SM, York JD (1999) SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J Biol Chem 274:12990\u201312995","journal-title":"J Biol Chem"},{"key":"12_CR110","first-page":"401","volume":"19","author":"Z Guoling","year":"1997","unstructured":"Guoling Z, Huijuan Y, Kaili X (1997) Loss of heterozygosity on chromosome 17p13.3 in ovarian cancer and cervical cancer. Chin J Oncol 19:401\u2013403","journal-title":"Chin J Oncol"},{"key":"12_CR111","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mce.2009.05.018","volume":"309","author":"A Gupta","year":"2009","unstructured":"Gupta A, Dey CS (2009) PTEN and SHIP2 regulates PI3K\/Akt pathway through focal adhesion kinase. Mol Cell Endocrinol 309:55\u201362","journal-title":"Mol Cell Endocrinol"},{"key":"12_CR112","doi-asserted-by":"crossref","first-page":"11376","DOI":"10.1074\/jbc.M209991200","volume":"278","author":"R Gurung","year":"2003","unstructured":"Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD, Prescott M, Whisstock JC, Mitchell CA (2003) Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization: the inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem 278:11376\u201311385","journal-title":"J Biol Chem"},{"key":"12_CR113","doi-asserted-by":"crossref","first-page":"18605","DOI":"10.1074\/jbc.273.29.18605","volume":"273","author":"T Habib","year":"1998","unstructured":"Habib T, Hejna JA, Moses RE, Decker SJ (1998) Growth factors and insulin stimulate tyrosine phosphorylation of the 51C\/SHIP2 protein. J Biol Chem 273:18605\u201318609","journal-title":"J Biol Chem"},{"key":"12_CR114","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4049\/jimmunol.0900427","volume":"183","author":"DJ Haddon","year":"2009","unstructured":"Haddon DJ, Antignano F, Hughes MR, Blanchet M-R, Zbytnuik L, Krystal G, McNagny KM (2009) SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. J Immunol 183:228\u2013236","journal-title":"J Immunol"},{"key":"12_CR115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0014-5793(97)01451-8","volume":"419","author":"C Haffner","year":"1997","unstructured":"Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler MH, Salcini AE, Di Fiore PP, De Camilli P (1997) Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170\u00a0kDa isoform with Eps15. FEBS Lett 419:175\u2013180","journal-title":"FEBS Lett"},{"issue":"1","key":"12_CR116","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exphem.2010.11.002","volume":"39","author":"MJ Hamilton","year":"2010","unstructured":"Hamilton MJ, Ho VW, Kuroda E, Ruschmann J, Antignano F, Lam V, Krystal G (2010) Role of SHIP in cancer. Exp Hematol 39(1):2\u201313","journal-title":"Exp Hematol"},{"key":"12_CR117","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/sj.ejhg.5201577","volume":"14","author":"DJ Hampshire","year":"2006","unstructured":"Hampshire DJ, Ayub M, Springell K, Roberts E, Jafri H, Rashid Y, Bond J, Riley JH, Woods CG (2006) MORM syndrome (mental retardation, truncal obesity, retinal dystrophy and micropenis), a new autosomal recessive disorder, links to 9q34. Eur J Hum Genet 14:543\u2013548","journal-title":"Eur J Hum Genet"},{"key":"12_CR118","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1083\/jcb.150.3.589","volume":"150","author":"TW Harris","year":"2000","unstructured":"Harris TW, Hartwieg E, Horvitz HR, Jorgensen EM (2000) Mutations in synaptojanin disrupt synaptic vesicle recycling. J Cell Biol 150:589\u2013600","journal-title":"J Cell Biol"},{"key":"12_CR119","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1158\/1078-0432.CCR-05-1417","volume":"12","author":"JM Hartikainen","year":"2006","unstructured":"Hartikainen JM, Tuhkanen H, Kataja V, Eskelinen M, Uusitupa M, Kosma V-M, Mannermaa A (2006) Refinement of the 22q12\u2013q13 breast cancer-associated region: evidence of TMPRSS6 as a candidate gene in an Eastern Finnish population. Clin Cancer Res 12:1454\u20131462","journal-title":"Clin Cancer Res"},{"key":"12_CR120","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1534-5807(03)00026-1","volume":"4","author":"V Haucke","year":"2003","unstructured":"Haucke V (2003) Where proteins and lipids meet: membrane trafficking on the move. Dev Cell 4:153\u2013157","journal-title":"Dev Cell"},{"key":"12_CR121","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/geno.1995.1247","volume":"29","author":"JA Hejna","year":"1995","unstructured":"Hejna JA, Saito H, Merkens LS, Tittle TV, Jakobs PM, Whitney MA, Grompe M, Friedberg AS, Moses RE (1995) Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases. Genomics 29:285\u2013287","journal-title":"Genomics"},{"key":"12_CR122","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1101\/gad.12.11.1610","volume":"12","author":"CD Helgason","year":"1998","unstructured":"Helgason CD, Damen JE, Rosten P, Grewal R, Sorensen P, Chappel SM, Borowski A, Jirik F, Krystal G, Humphries RK (1998) Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev 12:1610\u20131620","journal-title":"Genes Dev"},{"key":"12_CR123","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.191.5.781","volume":"191","author":"CD Helgason","year":"2000","unstructured":"Helgason CD, Kalberer CP, Damen JE, Chappel SM, Pineault N, Krystal G, Humphries RK (2000) A dual role for Src homology 2 domain-containing inositol-5-phosphatase (Ship) in immunity. J Exp Med 191:781\u2013794","journal-title":"J Exp Med"},{"key":"12_CR124","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1095\/biolreprod66.5.1522","volume":"66","author":"E Hellsten","year":"2002","unstructured":"Hellsten E, Bernard DJ, Owens JW, Eckhaus M, Suchy SF, Nussbaum RL (2002) Sertoli cell vacuolization and abnormal germ cell adhesion in mice deficient in an inositol polyphosphate 5-phosphatase. Biol Reprod 66:1522\u20131530","journal-title":"Biol Reprod"},{"key":"12_CR125","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1006\/dbio.2001.0476","volume":"240","author":"E Hellsten","year":"2001","unstructured":"Hellsten E, Evans JP, Bernard DJ, J\u00e4nne PA, Nussbaum RL (2001) Disrupted sperm function and fertilin \u03b2 processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp 5b. Dev Biol 240:641\u2013653","journal-title":"Dev Biol"},{"key":"12_CR126","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1126\/science.1098188","volume":"304","author":"LD Hernandez","year":"2004","unstructured":"Hernandez LD, Hueffer K, Wenk MR, Gal\u00e1n JE (2004) Salmonella modulates vesicular traffic by altering phosphoinositide metabolism. Science 304:1805\u20131807","journal-title":"Science"},{"key":"12_CR127","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ni.1886","volume":"11","author":"K Hitomi","year":"2010","unstructured":"Hitomi K, Tahara-Hanaoka S, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A (2010) An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Nat Immunol 11:601\u2013607","journal-title":"Nat Immunol"},{"key":"12_CR128","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1042\/bj2970637","volume":"297","author":"M Hodgkin","year":"1994","unstructured":"Hodgkin M, Craxton A, Parry J, Hughes P, Potter B, Michell R, Kirk C (1994) Bovine testis and human erythrocytes contain different subtypes of membrane-associated Ins(1,4,5)P3\/Ins(1,3,4,5)P4 5-phosphomonoesterases. Biochem J 297:637","journal-title":"Biochem J"},{"key":"12_CR129","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1158\/0008-5472.CAN-10-2314","volume":"71","author":"MC Hodgson","year":"2011","unstructured":"Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, Ayala G, Ittmann MM, Weigel NL, Agoulnik IU (2011) Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer. Cancer Res 71:572\u2013582","journal-title":"Cancer Res"},{"key":"12_CR130","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrc3037","volume":"11","author":"MC Hollander","year":"2011","unstructured":"Hollander MC, Blumenthal GM, Dennis PA (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 11:289\u2013301","journal-title":"Nat Rev Cancer"},{"key":"12_CR131","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1086\/427887","volume":"76","author":"RR Hoopes Jr","year":"2005","unstructured":"Hoopes RR Jr, Shrimpton AE, Knohl SJ, Hueber P, Hoppe B, Matyus J, Simckes A, Tasic V, Toenshoff B, Suchy SF, Nussbaum RL, Scheinman SJ (2005) Dent disease with mutations in OCRL1. Am J Hum Genet 76:260\u2013267","journal-title":"Am J Hum Genet"},{"key":"12_CR132","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1182\/blood-2007-02-073874","volume":"110","author":"KA Horan","year":"2007","unstructured":"Horan KA, Watanabe K-I, Kong AM, Bailey CG, Rasko JEJ, Sasaki T, Mitchell CA (2007) Regulation of Fc\u03b3R-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup. Blood 110:4480\u20134491","journal-title":"Blood"},{"key":"12_CR133","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.2337\/diabetes.51.8.2387","volume":"51","author":"H Hori","year":"2002","unstructured":"Hori H, Sasaoka T, Ishihara H, Wada T, Murakami S, Ishiki M, Kobayashi M (2002) Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db\/db Mice. Diabetes 51:2387\u20132394","journal-title":"Diabetes"},{"key":"12_CR134","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/sj.leu.2403529","volume":"18","author":"S Horn","year":"2004","unstructured":"Horn S, Endl E, Fehse B, Weck MM, Mayr GW, Jucker M (2004) Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase\/Akt\/GSK-3\u03b2 signaling and leads to an increased transit time through the G1 phase of the cell cycle. Leukemia 18:1839\u20131849","journal-title":"Leukemia"},{"key":"12_CR135","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1038\/emboj.2011.60","volume":"30","author":"X Hou","year":"2011","unstructured":"Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody RS, Erdmann KS, Itzen A (2011) A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J 30:1659\u20131670","journal-title":"EMBO J"},{"key":"12_CR136","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1073\/pnas.95.19.11330","volume":"95","author":"M Huber","year":"1998","unstructured":"Huber M, Helgason CD, Damen JE, Liu L, Humphries RK, Krystal G (1998a) The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A 95:11330\u201311335","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR137","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1093\/emboj\/17.24.7311","volume":"17","author":"M Huber","year":"1998","unstructured":"Huber M, Helgason CD, Scheid MP, Duronio V, Humphries RK, Krystal G (1998b) Targeted disruption of SHIP leads to steel factor-induced degranulation of mast cells. EMBO J 17:7311\u20137319","journal-title":"EMBO J"},{"key":"12_CR138","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/bj3500337","volume":"350","author":"WE Hughes","year":"2000","unstructured":"Hughes WE, Cooke FT, Parker PJ (2000) Sac phosphatase domain proteins. Biochem J 350:337\u2013352","journal-title":"Biochem J"},{"key":"12_CR139","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1462-5822.2008.01235.x","volume":"11","author":"CS Hung","year":"2009","unstructured":"Hung CS, Lin YL, Wu CI, Huang CJ, Ting LP (2009) Suppression of hepatitis B viral gene expression by phosphoinositide 5-phosphatase SKIP. Cell Microbiol 11:37\u201350","journal-title":"Cell Microbiol"},{"key":"12_CR140","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1038\/sj.emboj.7601274","volume":"25","author":"N Hyvola","year":"2006","unstructured":"Hyvola N, Diao A, McKenzie E, Skippen A, Cockcroft S, Lowe M (2006) Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J 25:3750\u20133761","journal-title":"EMBO J"},{"key":"12_CR141","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2010.07.016","volume":"328","author":"ME Hyvonen","year":"2010","unstructured":"Hyvonen ME, Saurus P, Wasik A, Heikkila E, Havana M, Trokovic R, Saleem M, Holthofer H, Lehtonen S (2010) Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes. Mol Cell Endocrinol 328:70\u201379","journal-title":"Mol Cell Endocrinol"},{"key":"12_CR142","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/j.1462-5822.2009.01368.x","volume":"11","author":"JA Ibarra","year":"2009","unstructured":"Ibarra JA, Steele-Mortimer O (2009) Salmonella\u2014the ultimate insider. Salmonella virulence factors that modulate intracellular survival. Cell Microbiol 11:1579\u20131586","journal-title":"Cell Microbiol"},{"key":"12_CR143","doi-asserted-by":"crossref","first-page":"10870","DOI":"10.1074\/jbc.275.15.10870","volume":"275","author":"T Ijuin","year":"2000","unstructured":"Ijuin T, Mochizuki Y, Fukami K, Funaki M, Asano T, Takenawa T (2000) Identification and characterization of a novel inositol polyphosphate 5- phosphatase. J Biol Chem 275:10870\u201310875","journal-title":"J Biol Chem"},{"key":"12_CR144","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1128\/MCB.23.4.1209-1220.2003","volume":"23","author":"T Ijuin","year":"2003","unstructured":"Ijuin T, Takenawa T (2003) SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation. Mol Cell Biol 23:1209\u20131220","journal-title":"Mol Cell Biol"},{"key":"12_CR145","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1128\/MCB.01990-06","volume":"28","author":"T Ijuin","year":"2008","unstructured":"Ijuin T, Yu YE, Mizutani K, Pao A, Tateya S, Tamori Y, Bradley A, Takenawa T (2008) Increased insulin action in SKIP heterozygous knockout mice. Mol Cell Biol 28:5184\u20135195","journal-title":"Mol Cell Biol"},{"key":"12_CR146","doi-asserted-by":"crossref","first-page":"26760","DOI":"10.1074\/jbc.C110.154658","volume":"285","author":"OC Ikonomov","year":"2010","unstructured":"Ikonomov OC, Sbrissa D, Fligger J, Delvecchio K, Shisheva A (2010) ArPIKfyve regulates Sac3 protein abundance and turnover. J Biol Chem 285:26760\u201326764","journal-title":"J Biol Chem"},{"key":"12_CR147","doi-asserted-by":"crossref","first-page":"23961","DOI":"10.1074\/jbc.M109.025361","volume":"284","author":"OC Ikonomov","year":"2009","unstructured":"Ikonomov OC, Sbrissa D, Ijuin T, Takenawa T, Shisheva A (2009) Sac3 is an insulin-regulated PtdIns(3,5)P2 phosphatase: gain in insulin responsiveness through Sac3 downregulation in adipocytes. J Biol Chem 284:23961\u201323971","journal-title":"J Biol Chem"},{"key":"12_CR148","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ncb1252","volume":"7","author":"F Irie","year":"2005","unstructured":"Irie F, Okuno M, Pasquale EB, Yamaguchi Y (2005) EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol 7:501\u2013509","journal-title":"Nat Cell Biol"},{"key":"12_CR149","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/01.mpa.0000222317.82231.16","volume":"33","author":"S Ishida","year":"2006","unstructured":"Ishida S, Funakoshi A, Miyasaka K, Shimokata H, Ando F, Takiguchi S (2006) Association of SH-2 containing inositol 5\u2019-phosphatase 2 gene polymorphisms and hyperglycemia. Pancreas 33:63\u201367","journal-title":"Pancreas"},{"key":"12_CR150","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/embor.2009.28","volume":"10","author":"I Ivetac","year":"2009","unstructured":"Ivetac I, Gurung R, Hakim S, Horan KA, Sheffield DA, Binge LC, Majerus PW, Tiganis T, Mitchell CA (2009) Regulation of PI(3)K\/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1. EMBO Rep 10:487\u2013493","journal-title":"EMBO Rep"},{"key":"12_CR151","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1091\/mbc.e04-09-0799","volume":"16","author":"I Ivetac","year":"2005","unstructured":"Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC, Rowe T, Majerus PW, Mitchell CA (2005) The type I\u03b1 inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell 16:2218\u20132233","journal-title":"Mol Biol Cell"},{"key":"12_CR152","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1002\/j.1460-2075.1995.tb00128.x","volume":"14","author":"S Jackson","year":"1995","unstructured":"Jackson S, Schoenwaelder S, Matzaris M, Brown S, CA M (1995) Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75\u00a0kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85\/p110 form of phosphoinositide 3-kinase. EMBO J 14:4490\u20134500","journal-title":"EMBO J"},{"key":"12_CR153","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/ng.427","volume":"41","author":"M Jacoby","year":"2009","unstructured":"Jacoby M, Cox JJ, Gayral S, Hampshire DJ, Ayub M, Blockmans M, Pernot E, Kisseleva MV, Comp\u00e8re P, Schiffmann SN, Gergely F, Riley JH, P\u00e9rez-Morga D, Woods CG, Schurmans S (2009) INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet 41:1027\u20131031","journal-title":"Nat Genet"},{"key":"12_CR154","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1172\/JCI2414","volume":"101","author":"PA J\u00e4nne","year":"1998","unstructured":"J\u00e4nne PA, Suchy SF, Bernard D, MacDonald M, Crawley J, Grinberg A, Wynshaw-Boris A, Westphal H, Nussbaum RL (1998) Functional overlap between murine Inpp 5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice. J Clin Investig 101:2042\u20132053","journal-title":"J Clin Investig"},{"key":"12_CR155","doi-asserted-by":"crossref","first-page":"9370","DOI":"10.1074\/jbc.270.16.9370","volume":"270","author":"AB Jefferson","year":"1995","unstructured":"Jefferson AB, Majerus PW (1995) Properties of type II inositol polyphosphate 5-phosphatase. J Biol Chem 270:9370\u20139377","journal-title":"J Biol Chem"},{"key":"12_CR156","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.devcel.2008.11.010","volume":"15","author":"J Jiang","year":"2008","unstructured":"Jiang J, Hui CC (2008) Hedgehog signaling in development and cancer. Dev Cell 15:801\u2013812","journal-title":"Dev Cell"},{"key":"12_CR157","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1182\/blood-2003-05-1550","volume":"102","author":"X Jiang","year":"2003","unstructured":"Jiang X, Stuible M, Chalandon Y, Li A, Chan WY, Eisterer W, Krystal G, Eaves A, Eaves C (2003) Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia. Blood 102:2976\u20132984","journal-title":"Blood"},{"key":"12_CR158","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.cell.2010.05.015","volume":"141","author":"H Jin","year":"2010","unstructured":"Jin H, White SR, Shida T, Schulz S, Aguiar M, Gygi SP, Bazan JF, Nachury MV (2010) The conserved Bardet\u2013Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell 141:1208\u20131219","journal-title":"Cell"},{"key":"12_CR159","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1158\/1078-0432.CCR-04-2225","volume":"11","author":"J Jones","year":"2005","unstructured":"Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, Jonas D, Libermann TA (2005) Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res 11:5730\u20135739","journal-title":"Clin Cancer Res"},{"key":"12_CR160","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000015448","volume":"87","author":"RE Joseph","year":"1999","unstructured":"Joseph RE, Walker J, Norris FA (1999) Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization. Cytogenet Cell Genet 87:276\u2013277","journal-title":"Cytogenet Cell Genet"},{"key":"12_CR161","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.cub.2007.08.036","volume":"17","author":"M Jospin","year":"2007","unstructured":"Jospin M, Watanabe S, Joshi D, Young S, Hamming K, Thacker C, Snutch TP, Jorgensen EM, Schuske K (2007) UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants. Curr Biol 17:1595\u20131600","journal-title":"Curr Biol"},{"key":"12_CR162","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1212\/WNL.19.9.813","volume":"19","author":"M Joubert","year":"1969","unstructured":"Joubert M, Eisenring J, Robb J, Andermann F (1969) Familial agenesis of the cerebellar vermis. A syndrome of episodic hyperpnea, abnormal eye movements, ataxia, and retardation. Neurology 19:813\u2013825","journal-title":"Neurology"},{"key":"12_CR163","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1210\/jc.2004-1724","volume":"90","author":"S Kagawa","year":"2005","unstructured":"Kagawa S, Sasaoka T, Yaguchi S, Ishihara H, Tsuneki H, Murakami S, Fukui K, Wada T, Kobayashi S, Kimura I, Kobayashi M (2005) Impact of SRC homology 2-containing inositol 5\u2019-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling. J Clin Endocrinol Metab 90:2911\u20132919","journal-title":"J Clin Endocrinol Metab"},{"key":"12_CR164","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1210\/en.2007-0820","volume":"149","author":"S Kagawa","year":"2008","unstructured":"Kagawa S, Soeda Y, Ishihara H, Oya T, Sasahara M, Yaguchi S, Oshita R, Wada T, Tsuneki H, Sasaoka T (2008) Impact of transgenic overexpression of SH2-containing inositol 5\u2019-phosphatase 2 on glucose metabolism and insulin signaling in mice. Endocrinology 149:642\u2013650","journal-title":"Endocrinology"},{"key":"12_CR165","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.2337\/diabetes.53.7.1900","volume":"53","author":"PJ Kaisaki","year":"2004","unstructured":"Kaisaki PJ, Delpine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S, Vionnet N, Marion E, Riveline JP, Charpentier G, Schurmans S, Levy JC, Lathrop M, Farrall M, Gauguier D (2004) Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. Diabetes 53:1900\u20131904","journal-title":"Diabetes"},{"key":"12_CR166","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0161-5890(02)00064-0","volume":"38","author":"J Kalesnikoff","year":"2002","unstructured":"Kalesnikoff J, Lam V, Krystal G (2002) SHIP represses mast cell activation and reveals that IgE alone triggers signaling pathways which enhance normal mast cell survival. Mol Immunol 38:1201\u20131206","journal-title":"Mol Immunol"},{"key":"12_CR167","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1091\/mbc.e07-01-0061","volume":"18","author":"LA Kamen","year":"2007","unstructured":"Kamen LA, Levinsohn J, Swanson JA (2007) Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes. Mol Biol Cell 18:2463\u20132472","journal-title":"Mol Biol Cell"},{"key":"12_CR168","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nrn2841","volume":"11","author":"M Karayiorgou","year":"2010","unstructured":"Karayiorgou M, Simon TJ, Gogos JA (2010) 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat Rev Neurosci 11:402\u2013416","journal-title":"Nat Rev Neurosci"},{"key":"12_CR169","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.4049\/jimmunol.176.7.3958","volume":"176","author":"M Kashiwada","year":"2006","unstructured":"Kashiwada M, Cattoretti G, McKeag L, Rouse T, Showalter BM, Al-Alem U, Niki M, Pandolfi PP, Field EH, Rothman PB (2006) Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5\u2019-phosphatase are required for regulation of CD4\u00a0+\u00a0CD25+ T Cell development. J Immunol 176:3958\u20133965","journal-title":"J Immunol"},{"key":"12_CR170","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1083\/jcb.200804162","volume":"182","author":"J Kasprowicz","year":"2008","unstructured":"Kasprowicz J, Kuenen S, Miskiewicz K, Habets RLP, Smitz L, Verstreken P (2008) Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. J Cell Biol 182:1007\u20131016","journal-title":"J Cell Biol"},{"key":"12_CR171","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1096-8628(19980605)77:5<348::AID-AJMG2>3.0.CO;2-J","volume":"77","author":"T Kawano","year":"1998","unstructured":"Kawano T, Indo Y, Nakazato H, Shimadzu M, Matsuda I (1998) Oculocerebrorenal syndrome of Lowe: three mutations in the OCRL1 gene derived from three patients with different phenotypes. Am J Med Genet 77:348\u2013355","journal-title":"Am J Med Genet"},{"key":"12_CR172","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ajmg.1320460312","volume":"46","author":"L Kenworthy","year":"1993","unstructured":"Kenworthy L, Park T, Charnas LR (1993) Cognitive and behavioral profile of the oculocerebrorenal syndrome of Lowe. Am J Med Genet 46:297\u2013303","journal-title":"Am J Med Genet"},{"key":"12_CR173","first-page":"8248","volume":"63","author":"B Kim","year":"2003","unstructured":"Kim B, Bang S, Lee S, Kim S, Jung Y, Lee C, Choi K, Lee S-G, Lee K, Lee Y, Kim S-S, Yeom Y-I, Kim Y-S, Yoo H-S, Song K, Lee I (2003) Expression profiling and subtype-specific expression of stomach cancer. Cancer Res 63:8248\u20138255","journal-title":"Cancer Res"},{"key":"12_CR174","doi-asserted-by":"crossref","first-page":"13991","DOI":"10.1074\/jbc.272.21.13991","volume":"272","author":"T Kimura","year":"1997","unstructured":"Kimura T, Sakamoto H, Appella E, Siraganian RP (1997) The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated \u03b2 subunit of the high affinity IgE receptor. J Biol Chem 272:13991\u201313996","journal-title":"J Biol Chem"},{"key":"12_CR175","doi-asserted-by":"crossref","first-page":"6266","DOI":"10.1074\/jbc.M105969200","volume":"277","author":"MV Kisseleva","year":"2002","unstructured":"Kisseleva MV, Cao L, Majerus PW (2002) Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt\/protein kinase B phosphorylation and leads to apoptotic cell death. J Biol Chem 277:6266\u20136272","journal-title":"J Biol Chem"},{"key":"12_CR176","doi-asserted-by":"crossref","first-page":"20110","DOI":"10.1074\/jbc.M910119199","volume":"275","author":"MV Kisseleva","year":"2000","unstructured":"Kisseleva MV, Wilson MP, Majerus PW (2000) The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase. J Biol Chem 275:20110\u201320116","journal-title":"J Biol Chem"},{"key":"12_CR177","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1034\/j.1600-0854.2003.00118.x","volume":"4","author":"LA Knodler","year":"2003","unstructured":"Knodler LA, Steele-Mortimer O (2003) Taking possession: biogenesis of the Salmonella-containing vacuole. Traffic 4:587\u2013599","journal-title":"Traffic"},{"key":"12_CR178","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1038\/sj.onc.1208558","volume":"24","author":"A Koch","year":"2005","unstructured":"Koch A, Mancini A, El Bounkari O, Tamura T (2005) The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading. Oncogene 24:3436\u20133447","journal-title":"Oncogene"},{"key":"12_CR179","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1128\/MCB.00203-06","volume":"26","author":"AM Kong","year":"2006","unstructured":"Kong AM, Horan KA, Sriratana A, Bailey CG, Collyer LJ, Nandurkar HH, Shisheva A, Layton MJ, Rasko JEJ, Rowe T, Mitchell CA (2006) Phosphatidylinositol 3-phosphate [PtdIns(3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane. Mol Cell Biol 26:6065\u20136081","journal-title":"Mol Cell Biol"},{"key":"12_CR180","doi-asserted-by":"crossref","first-page":"24052","DOI":"10.1074\/jbc.M000874200","volume":"275","author":"AM Kong","year":"2000","unstructured":"Kong AM, Speed CJ, O\u2019Malley CJ, Layton MJ, Meehan T, Loveland KL, Cheema S, Ooms LM, Mitchell CA (2000) Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. J Biol Chem 275:24052\u201324064","journal-title":"J Biol Chem"},{"key":"12_CR181","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1038\/sj.onc.1202128","volume":"17","author":"H Konishi","year":"1998","unstructured":"Konishi H, Takahashi T, Kozaki KI, Yatabe Y, Mitsudomi T, Fujii Y, Sugiura T, Matsuda H (1998) Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers. Oncogene 17:2095\u20132100","journal-title":"Oncogene"},{"key":"12_CR182","doi-asserted-by":"crossref","first-page":"10547","DOI":"10.1074\/jbc.M200090200","volume":"277","author":"G Konrad","year":"2002","unstructured":"Konrad G, Schlecker T, Faulhammer F, Mayinger P (2002) Retention of the yeast Sac1p phosphatase in the endoplasmic reticulum causes distinct changes in cellular phosphoinositide levels and stimulates microsomal ATP transport. J Biol Chem 277:10547\u201310554","journal-title":"J Biol Chem"},{"key":"12_CR183","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.chom.2011.03.010","volume":"9","author":"C Konradt","year":"2011","unstructured":"Konradt C, Frigimelica E, Nothelfer K, Puhar A, Salgado-Pabon W, di Bartolo V, Scott-Algara D, Rodrigues Cristina D, Sansonetti Philippe J, Phalipon A (2011) The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism. Cell Host Microbe 9:263\u2013272","journal-title":"Cell Host Microbe"},{"key":"12_CR184","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/jmg.2010.087528","volume":"48","author":"F Kort\u00fcm","year":"2011","unstructured":"Kort\u00fcm F, Das S, Flindt M, Morris-Rosendahl DJ, Stefanova I, Goldstein A, Horn D, Klopocki E, Kluger G, Martin P, Rauch A, Roumer A, Saitta S, Walsh LE, Wieczorek D, Uyanik G, Kutsche K, Dobyns WB (2011) The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis. J Med Genet 48:396\u2013406","journal-title":"J Med Genet"},{"key":"12_CR185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1399-0004.1998.tb04284.x","volume":"54","author":"T Kubota","year":"1998","unstructured":"Kubota T, Sakurai A, Arakawa K, Shirnazu M, Wakui K, Furihata K, Fukushirna Y (1998) Identification of two novel mutations in the OCRLI gene in Japanese families with Lowe syndrome. Clin Genet 54:199\u2013202","journal-title":"Clin Genet"},{"key":"12_CR186","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4049\/jimmunol.1002778","volume":"186","author":"E Kuroda","year":"2011","unstructured":"Kuroda E, Antignano F, Ho VW, Hughes MR, Ruschmann J, Lam V, Kawakami T, Kerr WG, McNagny KM, Sly LM, Krystal G (2011) SHIP represses Th2 skewing by inhibiting IL-4 production from basophils. J Immunol 186:323\u2013332","journal-title":"J Immunol"},{"key":"12_CR187","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1093\/hmg\/10.18.1907","volume":"10","author":"K Kurose","year":"2001","unstructured":"Kurose K, Hoshaw-Woodard S, Adeyinka A, Lemeshow S, Watson HP, Eng C (2001) Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour\u2013microenvironment interactions. Hum Mol Genet 10:1907\u20131913","journal-title":"Hum Mol Genet"},{"key":"12_CR188","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1128\/jb.88.5.1503-1518.1964","volume":"88","author":"EH Labrec","year":"1964","unstructured":"Labrec EH, Schneider H, Magnani TJ, Formal SB (1964) Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J Bacteriol 88:1503\u20131518","journal-title":"J Bacteriol"},{"key":"12_CR189","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1128\/IAI.69.7.4691-4694.2001","volume":"69","author":"X-H Lai","year":"2001","unstructured":"Lai X-H, Golovliov I, Sjostedt A (2001) Francisella tularensis induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplication. Infect Immun 69:4691\u20134694","journal-title":"Infect Immun"},{"key":"12_CR190","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1128\/IAI.71.8.4642-4646.2003","volume":"71","author":"X-H Lai","year":"2003","unstructured":"Lai X-H, Sjostedt A (2003) Delineation of the molecular mechanisms of Francisella tularensis-induced apoptosis in murine macrophages. Infect Immun 71:4642\u20134646","journal-title":"Infect Immun"},{"key":"12_CR191","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1182\/blood-2009-10-250217","volume":"116","author":"GK Lakhanpal","year":"2010","unstructured":"Lakhanpal GK, Vecchiarelli-Federico LM, Li YJ, Cui JW, Bailey ML, Spaner DE, Dumont DJ, Barber DL, Ben-David Y (2010) The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis. Blood 116:428\u2013436","journal-title":"Blood"},{"key":"12_CR192","doi-asserted-by":"crossref","first-page":"10396","DOI":"10.1074\/jbc.272.16.10396","volume":"272","author":"TD Lamkin","year":"1997","unstructured":"Lamkin TD, Walk SF, Liu L, Damen JE, Krystal G, Ravichandran KS (1997) Shc interaction with Src homology two domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP. J Biol Chem 272:10396\u201310401","journal-title":"J Biol Chem"},{"key":"12_CR193","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1158\/1078-0432.CCR-03-0721","volume":"10","author":"JM Lamont","year":"2004","unstructured":"Lamont JM, McManamy CS, Pearson AD, Clifford SC, Ellison DW (2004) Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 10:5482\u20135493","journal-title":"Clin Cancer Res"},{"key":"12_CR194","first-page":"4499","volume":"62","author":"E LaTulippe","year":"2002","unstructured":"LaTulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, Gerald WL (2002) Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 62:4499\u20134506","journal-title":"Cancer Res"},{"key":"12_CR195","doi-asserted-by":"crossref","first-page":"17305","DOI":"10.1016\/S0021-9258(17)32555-3","volume":"269","author":"KM Laxminarayan","year":"1994","unstructured":"Laxminarayan KM, Chan BK, Tetaz T, Bird PI, Mitchell CA (1994) Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase. J Biol Chem 269:17305\u201317310","journal-title":"J Biol Chem"},{"key":"12_CR196","doi-asserted-by":"crossref","first-page":"17305","DOI":"10.1016\/S0021-9258(17)32555-3","volume":"269","author":"KM Laxminarayan","year":"1993","unstructured":"Laxminarayan KM, Matzaris M, Speed CJ, Mitchell CA (1993) Purification and characterization of a 43-kDa membrane-associated inositol polyphosphate 5-phosphatase from human placenta. J Biol Chem 269:17305\u201317310","journal-title":"J Biol Chem"},{"key":"12_CR197","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/hmg\/2.4.461","volume":"2","author":"A-M Leahey","year":"1993","unstructured":"Leahey A-M, Charnas LR, Nussbaum RL (1993) Nonsense mutations in the OCRL-1 gene in patients with the oculocerebrorenal syndrome of Lowe. Hum Mol Genet 2:461\u2013463","journal-title":"Hum Mol Genet"},{"key":"12_CR198","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s003350010247","volume":"12","author":"SH Lee","year":"2001","unstructured":"Lee SH, Davison JA, Vidal SM, Belouchi A (2001) Cloning, expression and chromosomal location of NKX6B to 10q26, a region frequently deleted in brain tumors. Mamm Genome 12:157\u2013162","journal-title":"Mamm Genome"},{"key":"12_CR199","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1073\/pnas.0307813100","volume":"101","author":"SY Lee","year":"2004","unstructured":"Lee SY, Wenk MR, Kim Y, Nairn AC, De Camilli P (2004) Regulation of synaptojanin 1 by cyclin-dependent kinase five at synapses. Proc Natl Acad Sci U S A 101:546\u2013551","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR200","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0002-9440(10)65238-8","volume":"155","author":"J-R Leheste","year":"1999","unstructured":"Leheste J-R, Rolinski B, Vorum H, Hilpert J, Nykjaer A, Jacobsen C, Aucouturier P, Moskaug J\u00d8, Otto A, Christensen EI, Willnow TE (1999) Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 155:1361\u20131370","journal-title":"Am J Pathol"},{"key":"12_CR201","doi-asserted-by":"crossref","first-page":"e1002104","DOI":"10.1371\/journal.pgen.1002104","volume":"7","author":"GM Lenk","year":"2011","unstructured":"Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH (2011) Pathogenic Mechanism of the FIG4 mutation responsible for charcot-marie-tooth disease CMT4J. PLoS Genet 7:e1002104","journal-title":"PLoS Genet"},{"key":"12_CR202","doi-asserted-by":"crossref","first-page":"12721","DOI":"10.1021\/bi801713f","volume":"47","author":"M Leone","year":"2008","unstructured":"Leone M, Cellitti J, Pellecchia M (2008) NMR studies of a heterotypic Sam\u2013Sam domain association: the interaction between the lipid phosphatase Ship2 and the EphA2 receptor. Biochemistry 47:12721\u201312728","journal-title":"Biochemistry"},{"key":"12_CR203","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/mgme.1998.2687","volume":"64","author":"T Lin","year":"1998","unstructured":"Lin T, Orrison BM, Suchy SF, Lewis RA, Nussbaum RL (1998) Mutations are not uniformly distributed throughout the OCRL1 gene in Lowe syndrome patients. Mol Genet Metab 64:58\u201361","journal-title":"Mol Genet Metab"},{"key":"12_CR204","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/geno.1996.4374","volume":"39","author":"Q Liu","year":"1997","unstructured":"Liu Q, Dumont DJ (1997) Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP). Genomics 39:109\u2013112","journal-title":"Genomics"},{"key":"12_CR205","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1084\/jem.188.7.1333","volume":"188","author":"Q Liu","year":"1998","unstructured":"Liu Q, Oliveira-Dos-Santos AJ, Mariathasan S, Bouchard D, Jones J, Sarao R, Kozieradzki I, Ohashi PS, Penninger JM, Dumont DJ (1998a) The inositol polyphosphate 5-phosphatase Ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med 188:1333\u20131342","journal-title":"J Exp Med"},{"key":"12_CR206","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1101\/gad.13.7.786","volume":"13","author":"Q Liu","year":"1999","unstructured":"Liu Q, Sasaki T, Kozieradzki I, Wakeham A, Itie A, Dumont DJ, Penninger JM (1999) SHIP is a negative regulator of growth factor receptor-mediated PKB\/Akt activation and myeloid cell survival. Genes Dev 13:786\u2013791","journal-title":"Genes Dev"},{"key":"12_CR207","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1182\/blood.V91.8.2753.2753_2753_2759","volume":"91","author":"Q Liu","year":"1998","unstructured":"Liu Q, Shalaby F, Jones J, Bouchard D, Dumont DJ (1998b) The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis. Blood 91:2753\u20132759","journal-title":"Blood"},{"key":"12_CR208","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.plipres.2009.12.001","volume":"49","author":"Y Liu","year":"2010","unstructured":"Liu Y, Bankaitis VA (2010) Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res 49:201\u2013217","journal-title":"Prog Lipid Res"},{"key":"12_CR209","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1091\/mbc.e07-12-1290","volume":"19","author":"Y Liu","year":"2008","unstructured":"Liu Y, Boukhelifa M, Tribble E, Morin-Kensicki E, Uetrecht A, Bear JE, Bankaitis VA (2008) The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals. Mol Biol Cell 19:3080\u20133096","journal-title":"Mol Biol Cell"},{"key":"12_CR210","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.leukres.2009.04.032","volume":"33","author":"TC Lo","year":"2009","unstructured":"Lo TC, Barnhill LM, Kim Y, Nakae EA, Yu AL, Diccianni MB (2009) Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing. Leuk Res 33:1562\u20131566","journal-title":"Leuk Res"},{"key":"12_CR211","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/prca.200800147","volume":"3","author":"C L\u00f3pez-Pedrera","year":"2009","unstructured":"L\u00f3pez-Pedrera C, Barbarroja N, Villalba JM (2009) Novel biomarkers of atherosclerosis and cardiovascular risk in autoimmune diseases: genomics and proteomics approaches poteomics. Clin Appl 3:213\u2013225","journal-title":"Clin Appl"},{"key":"12_CR212","first-page":"164","volume":"83","author":"C Lowe","year":"1952","unstructured":"Lowe C, Terrey M, Maclachlan EA (1952) Organic-aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation: a clinical entity. AMA Am J Dis Child 83:164\u2013184","journal-title":"AMA Am J Dis Child"},{"key":"12_CR213","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1182\/blood.V93.6.1922.406k21_1922_1933","volume":"93","author":"DM Lucas","year":"1999","unstructured":"Lucas DM, Rohrschneider LR (1999) A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. Blood 93:1922\u20131933","journal-title":"Blood"},{"key":"12_CR214","first-page":"420","volume":"12","author":"JM Luo","year":"2004","unstructured":"Luo JM, Liu ZL, Hao HL, Wang FX, Dong ZR, Ohno R (2004) Mutation analysis of SHIP gene in acute leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:420\u2013426","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"12_CR215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.leu.2402725","volume":"17","author":"JM Luo","year":"2003","unstructured":"Luo JM, Yoshida H, Komura S, Ohishi N, Pan L, Shigeno K, Hanamura I, Miura K, Iida S, Ueda R, Naoe T, Akao Y, Ohno R, Ohnishi K (2003) Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia. Leukemia 17:1\u20138","journal-title":"Leukemia"},{"key":"12_CR216","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/ncb1258","volume":"7","author":"JP MacKeigan","year":"2005","unstructured":"MacKeigan JP, Murphy LO, Blenis J (2005) Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 7:591\u2013600","journal-title":"Nat Cell Biol"},{"key":"12_CR217","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1182\/blood-2009-07-230631","volume":"115","author":"K Maeda","year":"2010","unstructured":"Maeda K, Mehta H, Drevets DA, Coggeshall KM (2010) IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood 115:4699\u20134706","journal-title":"Blood"},{"key":"12_CR218","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature07638","volume":"458","author":"CA Maher","year":"2009","unstructured":"Maher CA, Kumar-Sinha C, Cao X, Kalyana-Sundaram S, Han B, Jing X, Sam L, Barrette T, Palanisamy N, Chinnaiyan AM (2009) Transcriptome sequencing to detect gene fusions in cancer. Nature 458:97\u2013101","journal-title":"Nature"},{"key":"12_CR219","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0960-9822(00)00778-8","volume":"10","author":"N Malecz","year":"2000","unstructured":"Malecz N, McCabe PC, Spaargaren C, Qiu R-G, Chuang Y, Symons M (2000) Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis. Curr Biol 10:1383\u20131386","journal-title":"Curr Biol"},{"key":"12_CR220","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1083\/jcb.200804131","volume":"182","author":"GV Mallo","year":"2008","unstructured":"Mallo GV, Espina M, Smith AC, Terebiznik MR, Alem\u00e1n A, Finlay BB, Rameh LE, Grinstein S, Brumell JH (2008) SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34. J Cell Biol 182:741\u2013752","journal-title":"J Cell Biol"},{"key":"12_CR221","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/emboj.2010.57","volume":"29","author":"A Manford","year":"2010","unstructured":"Manford A, Xia T, Saxena AK, Stefan C, Hu F, Emr SD, Mao Y (2010) Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. EMBO J 29:1489\u20131498","journal-title":"EMBO J"},{"key":"12_CR222","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.neuron.2007.10.032","volume":"56","author":"M Mani","year":"2007","unstructured":"Mani M, Lee SY, Lucast L, Cremona O, Di Paolo G, De Camilli P, Ryan TA (2007) The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals. Neuron 56:1004\u20131018","journal-title":"Neuron"},{"key":"12_CR223","doi-asserted-by":"crossref","first-page":"e17607","DOI":"10.1371\/journal.pone.0017607","volume":"6","author":"SSM Manji","year":"2011","unstructured":"Manji SSM, Williams LH, Miller KA, Ooms LM, Bahlo M, Mitchell CA, Dahl H-HM (2011) A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. PLoS ONE 6:e17607","journal-title":"PLoS ONE"},{"key":"12_CR224","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/eji.200636910","volume":"37","author":"A Mantovani","year":"2007","unstructured":"Mantovani A, Sica A, Locati M (2007) New vistas on macrophage differentiation and activation. Eur J Immunol 37:14\u201316","journal-title":"Eur J Immunol"},{"key":"12_CR225","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/emboj.2009.155","volume":"28","author":"Y Mao","year":"2009","unstructured":"Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P (2009) A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. EMBO J 28:1831\u20131842","journal-title":"EMBO J"},{"key":"12_CR226","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/molehr\/gaq029","volume":"16","author":"MR Marcello","year":"2010","unstructured":"Marcello MR, Evans JP (2010) Multivariate analysis of male reproductive function in Inpp 5b\u2212\/\u2212 mice reveals heterogeneity in defects in fertility, sperm\u2013egg membrane interaction and proteolytic cleavage of sperm ADAMs. Mol Hum Reprod 16:492\u2013505","journal-title":"Mol Hum Reprod"},{"key":"12_CR227","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0014-5793(01)02356-0","volume":"494","author":"SL Marcus","year":"2001","unstructured":"Marcus SL, Wenk MR, Steele-Mortimer O, Finlay BB (2001) A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation. FEBS Lett 494:201\u2013207","journal-title":"FEBS Lett"},{"key":"12_CR228","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.2337\/diabetes.51.7.2012","volume":"51","author":"E Marion","year":"2002","unstructured":"Marion E, Kaisaki PJ, Pouillon V, Gueydan C, Levy JC, Bodson A, Krzentowski G, Daubresse JC, Mockel J, Behrends J, Servais G, Szpirer C, Kruys V, Gauguier D, Schurmans S (2002) The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. Diabetes 51:2012\u20132017","journal-title":"Diabetes"},{"key":"12_CR229","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.advenzreg.2010.11.006","volume":"51","author":"J Marjanovic","year":"2011","unstructured":"Marjanovic J, Wilson MP, Zhang C, Zou J, Nicholas P, Majerus PW (2011) The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model. Adv Enzyme Regul 51:101\u2013105","journal-title":"Adv Enzyme Regul"},{"key":"12_CR230","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1091\/mbc.e07-07-0719","volume":"19","author":"E Marza","year":"2008","unstructured":"Marza E, Long T, Saiardi A, Sumakovic M, Eimer S, Hall DH, Lesa GM (2008) Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling. Mol Biol Cell 19:833\u2013842","journal-title":"Mol Biol Cell"},{"key":"12_CR231","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1016\/S0021-9258(17)41875-8","volume":"269","author":"M Matzaris","year":"1994","unstructured":"Matzaris M, Jackson SP, Laxminarayan KM, Speed CJ, Mitchell CA (1994) Identification and characterization of the phosphatidylinositol-(4, 5)-bisphosphate 5-phosphatase in human platelets. J Biol Chem 269:3397\u20133402","journal-title":"J Biol Chem"},{"key":"12_CR232","doi-asserted-by":"crossref","first-page":"8256","DOI":"10.1074\/jbc.273.14.8256","volume":"273","author":"M Matzaris","year":"1998","unstructured":"Matzaris M, O\u2019Malley CJ, Badger A, Speed CJ, Bird PI, Mitchell CA (1998) Distinct membrane and cytosolic forms of inositol polyphosphate 5-phosphatase II. J Biol Chem 273:8256\u20138267","journal-title":"J Biol Chem"},{"key":"12_CR233","doi-asserted-by":"crossref","first-page":"32196","DOI":"10.1074\/jbc.M400746200","volume":"279","author":"MJ Maxwell","year":"2004","unstructured":"Maxwell MJ, Yuan Y, Anderson KE, Hibbs ML, Salem HH, Jackson SP (2004) SHIP1 and Lyn kinase negatively regulate integrin \u03b1IIb\u03b23 signaling in platelets. J Biol Chem 279:32196\u201332204","journal-title":"J Biol Chem"},{"key":"12_CR234","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/379353a0","volume":"379","author":"PS McPherson","year":"1996","unstructured":"McPherson PS, Garcia EP, Slepnev VI, David C, Zhang X, Grabs D, Sossini WS, Bauerfeind R, Nemoto Y, De Camilli P (1996) A presynaptic inositol-5-phosphatase. Nature 379:353\u2013357","journal-title":"Nature"},{"key":"12_CR235","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/gt.2008.184","volume":"16","author":"A Metzner","year":"2009","unstructured":"Metzner A, Precht C, Fehse B, Fiedler W, Stocking C, G\u00fcnther A, Mayr GW, J\u00fccker M (2009) Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D. Gene Ther 16:570\u2013573","journal-title":"Gene Ther"},{"key":"12_CR236","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1084\/jem.20091962","volume":"207","author":"AV Miletic","year":"2010","unstructured":"Miletic AV, Anzelon-Mills AN, Mills DM, Omori SA, Pedersen IM, Shin D-M, Ravetch JV, Bolland S, Morse HC, Rickert RC (2010) Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases. J Exp Med 207:2407\u20132420","journal-title":"J Exp Med"},{"key":"12_CR237","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1523\/JNEUROSCI.3761-04.2005","volume":"25","author":"I Milosevic","year":"2005","unstructured":"Milosevic I, Sorensen JB, Lang T, Krauss M, Nagy GB, Haucke V, Jahn R, Neher E (2005) Plasmalemmal phosphatidylinositol-4,5-bisphosphate level regulates the releasable vesicle pool size in chromaffin cells. J Neurosci 25:2557\u20132565","journal-title":"J Neurosci"},{"key":"12_CR238","doi-asserted-by":"crossref","first-page":"22011","DOI":"10.1074\/jbc.M101579200","volume":"276","author":"T Minagawa","year":"2001","unstructured":"Minagawa T, Ijuin T, Mochizuki Y, Takenawa T (2001) Identification and characterization of a Sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem 276:22011\u201322015","journal-title":"J Biol Chem"},{"key":"12_CR239","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1016\/S0021-9258(18)81874-9","volume":"264","author":"CA Mitchell","year":"1989","unstructured":"Mitchell CA, Connolly TM, Majerus PW (1989) Identification and isolation of a 75-kDa inositol polyphosphate-5-phosphatase from human platelets. J Biol Chem 264:8873\u20138877","journal-title":"J Biol Chem"},{"key":"12_CR240","doi-asserted-by":"crossref","first-page":"36790","DOI":"10.1074\/jbc.274.51.36790","volume":"274","author":"Y Mochizuki","year":"1999","unstructured":"Mochizuki Y, Takenawa T (1999) Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. J Biol Chem 274:36790\u201336795","journal-title":"J Biol Chem"},{"key":"12_CR241","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1073\/pnas.96.7.3640","volume":"96","author":"AD Munday","year":"1999","unstructured":"Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA (1999) The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. Proc Natl Acad Sci U S A 96:3640\u20133645","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR242","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0306-4522(01)00240-8","volume":"105","author":"E Muraille","year":"2001","unstructured":"Muraille E, Dassesse D, Vanderwinden JM, Cremer H, Rogister B, Erneux C, Schiffmann SN (2001) The SH2 domain-containing 5-phosphatase SHIP2 is expressed in the germinal layers of embryo and adult mouse brain: increased expression in N-CAM-deficient mice. Neuroscience 105:1019\u20131030","journal-title":"Neuroscience"},{"key":"12_CR243","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1182\/blood-2002-03-0787","volume":"100","author":"K Nakamura","year":"2002","unstructured":"Nakamura K, Malykhin A, Coggeshall KM (2002) The Src homology two domain-containing inositol 5-phosphatase negatively regulates Fc\u03b3 receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors. Blood 100:3374\u20133382","journal-title":"Blood"},{"key":"12_CR244","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.201005018","volume":"190","author":"F Nakatsu","year":"2010","unstructured":"Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P (2010) The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. J Cell Biol 190:307\u2013315","journal-title":"J Cell Biol"},{"key":"12_CR245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/bcr1356","volume":"7","author":"T Naylor","year":"2005","unstructured":"Naylor T, Greshock J, Wang Y, Colligon T, Yu QC, Clemmer V, Zaks T, Weber B (2005) High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res 7:1\u201313","journal-title":"Breast Cancer Res"},{"key":"12_CR246","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.exphem.2007.01.048","volume":"35","author":"L Neill","year":"2007","unstructured":"Neill L, Tien AH, Rey-Ladino J, Helgason CD (2007) SHIP-deficient mice provide insights into the regulation of dendritic cell development and function. Exp Hematol 35:627\u2013639","journal-title":"Exp Hematol"},{"key":"12_CR247","doi-asserted-by":"crossref","first-page":"30817","DOI":"10.1074\/jbc.272.49.30817","volume":"272","author":"Y Nemoto","year":"1997","unstructured":"Nemoto Y, Arribas M, Haffner C, DeCamilli P (1997) Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern. J Biol Chem 272:30817\u201330821","journal-title":"J Biol Chem"},{"key":"12_CR248","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1093\/emboj\/18.11.2991","volume":"18","author":"Y Nemoto","year":"1999","unstructured":"Nemoto Y, De Camilli P (1999) Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein. EMBO J 18:2991\u20133006","journal-title":"EMBO J"},{"key":"12_CR249","doi-asserted-by":"crossref","first-page":"34293","DOI":"10.1074\/jbc.M003923200","volume":"275","author":"Y Nemoto","year":"2000","unstructured":"Nemoto Y, Kearns BG, Wenk MR, Chen H, Mori K, Alb JG, De Camilli P, Bankaitis VA (2000) Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity. J Biol Chem 275:34293\u201334305","journal-title":"J Biol Chem"},{"key":"12_CR250","doi-asserted-by":"crossref","first-page":"41133","DOI":"10.1074\/jbc.M106404200","volume":"276","author":"Y Nemoto","year":"2001","unstructured":"Nemoto Y, Wenk MR, Watanabe M, Daniell L, Murakami T, Ringstad N, Yamada H, Takei K, De Camilli P (2001) Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. J Biol Chem 276:41133\u201341142","journal-title":"J Biol Chem"},{"key":"12_CR251","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1182\/blood-2011-01-331041","volume":"117","author":"N-YN Nguyen","year":"2011","unstructured":"Nguyen N-YN, Maxwell MJ, Ooms LM, Davies EM, Hilton AA, Collinge JE, Hilton DJ, Kile BT, Mitchell CA, Hibbs ML, Jane SM, Curtis DJ (2011) An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood 117:5362\u20135371","journal-title":"Blood"},{"key":"12_CR252","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1093\/emboj\/cdf522","volume":"21","author":"K Niebuhr","year":"2002","unstructured":"Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B (2002) Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J 21:5069\u20135078","journal-title":"EMBO J"},{"key":"12_CR253","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1365-2958.2000.02041.x","volume":"38","author":"K Niebuhr","year":"2000","unstructured":"Niebuhr K, Jouihri N, Allaoui A, Gounon P, Sansonetti PJ, Parsot C (2000) IpgD, a protein secreted by the type III secretion machinery of Shigella flexneri, is chaperoned by IpgE and implicated in entry focus formation. Mol Microbiol 38:8\u201319","journal-title":"Mol Microbiol"},{"key":"12_CR254","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2009.10.036","volume":"139","author":"EA Nigg","year":"2009","unstructured":"Nigg EA, Raff JW (2009) Centrioles, centrosomes, and cilia in health and disease. Cell 139:663\u2013678","journal-title":"Cell"},{"key":"12_CR255","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ncb1515","volume":"9","author":"M Nishio","year":"2007","unstructured":"Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, Balla T, Yamazaki M, Watanabe H, Itoh R, Kuroda S, Horie Y, F\u00f6rster I, Mak TW, Yonekawa H, Penninger JM, Kanaho Y, Suzuki A, Sasaki T (2007) Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol 9:36\u201344","journal-title":"Nat Cell Biol"},{"key":"12_CR256","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1091\/mbc.e10-08-0730","volume":"22","author":"CJ Noakes","year":"2011","unstructured":"Noakes CJ, Lee G, Lowe M (2011) The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway. Mol Biol Cell 22:606\u2013623","journal-title":"Mol Biol Cell"},{"key":"12_CR257","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1681\/ASN.V131125","volume":"13","author":"AGW Norden","year":"2002","unstructured":"Norden AGW, Lapsley M, Igarashi T, Kelleher CL, Lee PJ, Matsuyama T, Scheinman SJ, Shiraga H, Sundin DP, Thakker RV, Unwin RJ, Verroust P, Moestrup SK (2002) Urinary megalin deficiency implicates abnormal tubular endocytic function in fanconi syndrome. J Am Soc Nephrol 13:125\u2013133","journal-title":"J Am Soc Nephrol"},{"key":"12_CR258","doi-asserted-by":"crossref","first-page":"23859","DOI":"10.1074\/jbc.272.38.23859","volume":"272","author":"FA Norris","year":"1997","unstructured":"Norris FA, Atkins RC, Majerus PW (1997a) The cDNA cloning and characterization of inositol polyphosphate 4- phosphatase type II. Evidence for conserved alternative splicing in the 4- phosphatase family. J Biol Chem 272:23859\u201323864","journal-title":"J Biol Chem"},{"key":"12_CR259","doi-asserted-by":"crossref","first-page":"10987","DOI":"10.1074\/jbc.272.17.10987","volume":"272","author":"FA Norris","year":"1997","unstructured":"Norris FA, Atkins RC, Majerus PW (1997b) Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets. J Biol Chem 272:10987\u201310989","journal-title":"J Biol Chem"},{"key":"12_CR260","doi-asserted-by":"crossref","first-page":"16128","DOI":"10.1074\/jbc.270.27.16128","volume":"270","author":"FA Norris","year":"1995","unstructured":"Norris FA, Auethavekiat V, Majerus PW (1995) The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. J Biol Chem 270:16128\u201316133","journal-title":"J Biol Chem"},{"key":"12_CR261","doi-asserted-by":"crossref","first-page":"8716","DOI":"10.1016\/S0021-9258(17)37027-8","volume":"269","author":"FA Norris","year":"1994","unstructured":"Norris FA, Majerus PW (1994) Hydrolysis of phosphatidylinositol 3,4-bisphosphate by inositol polyphosphate 4-phosphatase isolated by affinity elution chromatography. J Biol Chem 269:8716\u20138720","journal-title":"J Biol Chem"},{"key":"12_CR262","doi-asserted-by":"crossref","first-page":"14057","DOI":"10.1073\/pnas.95.24.14057","volume":"95","author":"FA Norris","year":"1998","unstructured":"Norris FA, Wilson MP, Wallis TS, Galyov EE, Majerus PW (1998) SopB, a protein required for virulence of Salmonella Dublin, is an inositol phosphate phosphatase. Proc Natl Acad Sci U S A 95:14057\u201314059","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR263","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/genetics\/121.4.659","volume":"121","author":"P Novick","year":"1989","unstructured":"Novick P, Osmond BC, Botstein D (1989) Suppressors of yeast actin mutations. Genetics 121:659\u2013674","journal-title":"Genetics"},{"key":"12_CR264","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0896-6273(01)00468-8","volume":"32","author":"A Nystuen","year":"2001","unstructured":"Nystuen A, Legare ME, Shultz LD, Frankel WN (2001) A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron 32:203\u2013212","journal-title":"Neuron"},{"key":"12_CR265","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1073\/pnas.0902636106","volume":"106","author":"RM O\u2019Connell","year":"2009","unstructured":"O\u2019Connell RM, Chaudhuri AA, Rao DS, Baltimore D (2009) Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A 106:7113\u20137118","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR266","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaci.2006.08.029","volume":"119","author":"S-Y Oh","year":"2007","unstructured":"Oh S-Y, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim Y-K, Zhu Z (2007) Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung. J Allergy Clin Immunol 119:123\u2013131","journal-title":"J Allergy Clin Immunol"},{"key":"12_CR267","first-page":"817","volume":"57","author":"I Olivos-Glander","year":"1995","unstructured":"Olivos-Glander I, J\u00e4nne P, Nussbaum R (1995) The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex. Am J Hum Genet 57:817\u2013823","journal-title":"Am J Hum Genet"},{"key":"12_CR268","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1182\/blood-2007-03-079699","volume":"110","author":"CJ Ong","year":"2007","unstructured":"Ong CJ, Ming-Lum A, Nodwell M, Ghanipour A, Yang L, Williams DE, Kim J, Demirjian L, Qasimi P, Ruschmann J, Cao LP, Ma K, Chung SW, Duronio V, Andersen RJ, Krystal G, Mui AL (2007) Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood 110:1942\u20131949","journal-title":"Blood"},{"key":"12_CR269","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1091\/mbc.e05-05-0469","volume":"17","author":"LM Ooms","year":"2006","unstructured":"Ooms LM, Fedele CG, Astle MV, Ivetac I, Cheung V, Pearson RB, Layton MJ, Forrai A, Nandurkar HH, Mitchell CA (2006) The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. Mol Biol Cell 17:607\u2013622","journal-title":"Mol Biol Cell"},{"key":"12_CR270","doi-asserted-by":"crossref","first-page":"29271","DOI":"10.1074\/jbc.271.46.29271","volume":"271","author":"MA Osborne","year":"1996","unstructured":"Osborne MA, Zenner G, Lubinus M, Zhang X, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP (1996) The inositol 5\u2032-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J Biol Chem 271:29271\u201329278","journal-title":"J Biol Chem"},{"key":"12_CR271","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/GIM.0b013e31816b64c2","volume":"10","author":"Z Ou","year":"2008","unstructured":"Ou Z, Berg JS, Yonath H, Enciso VB, Miller DT, Picker J, Lenzi T, Keegan CE, Sutton VR, Belmont J, Chinault AC, Lupski JR, Cheung SW, Roeder E, Patel A (2008) Microduplications of 22q11.2 are frequently inherited and are associated with variable phenotypes. Genet Med 10:267\u2013277","journal-title":"Genet Med"},{"key":"12_CR272","first-page":"969","volume":"18","author":"I Palomo","year":"2006","unstructured":"Palomo I, Alarcon M, Moore-Carrasco R, Argiles JM (2006) Hemostasis alterations in metabolic syndrome. Int J Mol Med 18:969\u2013974","journal-title":"Int J Mol Med"},{"key":"12_CR273","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature02896","volume":"431","author":"GD Paolo","year":"2004","unstructured":"Paolo GD, Moskowitz HS, Gipson K, Wenk MR, Voronov S, Obayashi M, Flavell R, Fitzsimonds RM, Ryan TA, Camilli PD (2004) Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature 431:415\u2013422","journal-title":"Nature"},{"key":"12_CR274","doi-asserted-by":"crossref","first-page":"11056","DOI":"10.1523\/JNEUROSCI.1941-07.2007","volume":"27","author":"JA Parker","year":"2007","unstructured":"Parker JA, Metzler M, Georgiou J, Mage M, Roder JC, Rose AM, Hayden MR, Neri C (2007) Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects caenorhabditis elegans neurons against mutant polyglutamine toxicity. J Neurosci 27:11056\u201311064","journal-title":"J Neurosci"},{"key":"12_CR275","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.canlet.2004.08.026","volume":"222","author":"P Parrella","year":"2005","unstructured":"Parrella P, Scintu M, Prencipe M, Poeta ML, Gallo AP, Rabitti C, Rinaldi M, Tommasi S, Paradiso A, Schittulli F, Valori VM, Toma S, Altomare V, Fazio VM (2005) HIC1 promoter methylation and 17p13.3 allelic loss in invasive ductal carcinoma of the breast. Cancer Lett 222:75\u201381","journal-title":"Cancer Lett"},{"key":"12_CR276","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1371\/journal.ppat.0020071","volume":"2","author":"KV Parsa","year":"2006","unstructured":"Parsa KV, Ganesan LP, Rajaram MV, Gavrilin MA, Balagopal A, Mohapatra NP, Wewers MD, Schlesinger LS, Gunn JS, Tridandapani S (2006) Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP. PLoS Pathog 2:e71","journal-title":"PLoS Pathog"},{"key":"12_CR277","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1111\/j.1742-4658.2005.04996.x","volume":"272","author":"N Paternotte","year":"2005","unstructured":"Paternotte N, Zhang J, Vandenbroere I, Backers K, Blero D, Kioka N, Vanderwinden JM, Pirson I, Erneux C (2005) SHIP2 interaction with the cytoskeletal protein Vinexin. FEBS J 272:6052\u20136066","journal-title":"FEBS J"},{"key":"12_CR278","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00439-009-0696-8","volume":"126","author":"D Patterson","year":"2009","unstructured":"Patterson D (2009) Molecular genetic analysis of Down syndrome. Hum Genet 126:195\u2013214","journal-title":"Hum Genet"},{"key":"12_CR279","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/emmm.200900028","volume":"1","author":"IM Pedersen","year":"2009","unstructured":"Pedersen IM, Otero D, Kao E, Miletic AV, Hother C, Ralfkiaer E, Rickert RC, Gronbaek K, David M (2009) Onco-miR-155 targets SHIP1 to promote TNF\u03b1-dependent growth of B cell lymphomas. EMBO Mol Med 1:288\u2013295","journal-title":"EMBO Mol Med"},{"key":"12_CR280","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/sj.emboj.7601001","volume":"25","author":"C Pendaries","year":"2006","unstructured":"Pendaries C, Tronch\u00e8re H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B (2006) PtdIns(5)P activates the host cell PI3-kinase\/Akt pathway during Shigella flexneri infection. EMBO J 25:1024\u20131034","journal-title":"EMBO J"},{"key":"12_CR281","doi-asserted-by":"crossref","unstructured":"Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB (2010) TREM2- and DAP12-dependent activation of PI3\u00a0K requires DAP10 and is inhibited by SHIP1. Sci Signal 3:ra38","DOI":"10.1126\/scisignal.2000500"},{"key":"12_CR282","doi-asserted-by":"crossref","first-page":"19332","DOI":"10.1073\/pnas.0609795104","volume":"103","author":"RM Perera","year":"2006","unstructured":"Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D (2006) Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proc Natl Acad Sci U S A 103:19332\u201319337","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"12_CR283","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00424-011-1028-0","volume":"462","author":"E Pernot","year":"2011","unstructured":"Pernot E, Terryn S, Cheong S, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier B, Beauwens R, Erneux C, Devuyst O, Schurmans S (2011) The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system. Pfl\u00fcgers Archiv Eur J Physiol 462(6):871-883","journal-title":"Pfl\u00fcgers Archiv Eur J Physiol"},{"key":"12_CR284","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1006\/bbrc.1997.7538","volume":"239","author":"X Pesesse","year":"1997","unstructured":"Pesesse X, Deleu S, De Smedt F, Drayer L, Erneux C (1997) Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. Biochem Biophys Res Commun 239:697\u2013700","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR285","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1034\/j.1399-0004.2000.580609.x","volume":"58","author":"J Peverall","year":"2000","unstructured":"Peverall J, Edkins E, Goldblatt J, Murch A (2000) Identification of a novel deletion of the entire OCRL1 gene detected by FISH analysis in a family with Lowe syndrome. Clin Genet 58:479\u2013482","journal-title":"Clin Genet"},{"key":"12_CR286","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nsmb.2071","volume":"18","author":"M Pirruccello","year":"2011","unstructured":"Pirruccello M, Swan LE, Folta-Stogniew E, De Camilli P (2011) Recognition of the F&H motif by the Lowe syndrome protein OCRL. Nat Struct Mol Biol 18:789\u2013795","journal-title":"Nat Struct Mol Biol"},{"key":"12_CR287","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tcb.2004.09.016","volume":"14","author":"FJ Pixley","year":"2004","unstructured":"Pixley FJ, Stanley ER (2004) CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol 14:628\u2013638","journal-title":"Trends Cell Biol"},{"key":"12_CR288","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/s-0030-1249630","volume":"40","author":"A Poretti","year":"2009","unstructured":"Poretti A, Dietrich-Alber F, Brancati F, Dallapiccola B, Valente EM, Boltshauser E (2009) Normal cognitive functions in Joubert syndrome. Neuropediatrics 40:287\u2013290","journal-title":"Neuropediatrics"},{"key":"12_CR289","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1128\/MCB.21.4.1416-1428.2001","volume":"21","author":"N Prasad","year":"2001","unstructured":"Prasad N, Topping RS, Decker SJ (2001) SH2-containing inositol 5\u2019-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. Mol Cell Biol 21:1416\u20131428","journal-title":"Mol Cell Biol"},{"key":"12_CR290","doi-asserted-by":"crossref","first-page":"13129","DOI":"10.1074\/jbc.M410289200","volume":"280","author":"NK Prasad","year":"2005","unstructured":"Prasad NK, Decker SJ (2005) SH2-containing 5\u2019-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor. J Biol Chem 280:13129\u201313136","journal-title":"J Biol Chem"},{"key":"12_CR291","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/carcin\/bgm213","volume":"29","author":"NK Prasad","year":"2008","unstructured":"Prasad NK, Tandon M, Badve S, Snyder PW, Nakshatri H (2008a) Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover. Carcinogenesis 29:25\u201334","journal-title":"Carcinogenesis"},{"key":"12_CR292","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1159\/000172970","volume":"29","author":"NK Prasad","year":"2008","unstructured":"Prasad NK, Tandon M, Handa A, Moore GE, Babbs CF, Snyder PW, Bose S (2008b) High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival. Tumour Biol 29:330\u2013341","journal-title":"Tumour Biol"},{"key":"12_CR293","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1021\/bi900492d","volume":"48","author":"NK Prasad","year":"2009","unstructured":"Prasad NK, Werner ME, Decker SJ (2009) Specific tyrosine phosphorylations mediate signal-dependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activity. Biochemistry 48:6285\u20136287","journal-title":"Biochemistry"},{"key":"12_CR294","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/gcc.20018","volume":"40","author":"BJ Quade","year":"2004","unstructured":"Quade BJ, Wang T-Y, Sornberger K, Cin PD, Mutter GL, Morton CC (2004) Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling. Genes Chromosom Cancer 40:97\u2013108","journal-title":"Genes Chromosom Cancer"},{"key":"12_CR295","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1091\/mbc.10.2.501","volume":"10","author":"B Qualmann","year":"1999","unstructured":"Qualmann B, Roos J, DiGregorio PJ, Kelly RB (1999) Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott\u2013Aldrich syndrome protein. Mol Biol Cell 10:501\u2013513","journal-title":"Mol Biol Cell"},{"key":"12_CR296","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.cellsig.2006.12.015","volume":"19","author":"JH Raaijmakers","year":"2007","unstructured":"Raaijmakers JH, Deneubourg L, Rehmann H, de Koning J, Zhang Z, Krugmann S, Erneux C, Bos JL (2007) The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. Cell Signal 19:1249\u20131257","journal-title":"Cell Signal"},{"issue":"34","key":"12_CR297","doi-asserted-by":"crossref","first-page":"29758","DOI":"10.1074\/jbc.M111.263103","volume":"286","author":"P Rahman","year":"2011","unstructured":"Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA (2011) Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)\/Akt signalling to the actin cytoskeleton. J Biol Chem 286(34):29758\u201329770","journal-title":"J Biol Chem"},{"key":"12_CR298","doi-asserted-by":"crossref","first-page":"e7919","DOI":"10.1371\/journal.pone.0007919","volume":"4","author":"MVS Rajaram","year":"2009","unstructured":"Rajaram MVS, Butchar JP, Parsa KVL, Cremer TJ, Amer A, Schlesinger LS, Tridandapani S (2009) Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway. PLoS ONE 4:e7919","journal-title":"PLoS ONE"},{"key":"12_CR299","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","volume":"33","author":"S Ramaswamy","year":"2003","unstructured":"Ramaswamy S, Ross KN, Lander ES, Golub TR (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49\u201354","journal-title":"Nat Genet"},{"key":"12_CR300","doi-asserted-by":"crossref","first-page":"24856","DOI":"10.1074\/jbc.271.40.24856","volume":"271","author":"AR Ramjaun","year":"1996","unstructured":"Ramjaun AR, McPherson PS (1996) Tissue-specific alternative splicing generates two synaptojanin isoforms with differential membrane binding properties. J Biol Chem 271:24856\u201324861","journal-title":"J Biol Chem"},{"key":"12_CR301","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.immuni.2005.09.003","volume":"23","author":"MJ Rauh","year":"2005","unstructured":"Rauh MJ, Ho V, Pereira C, Sham A, Sly LM, Lam V, Huxham L, Minchinton AI, Mui A, Krystal G (2005) SHIP represses the generation of alternatively activated macrophages. Immunity 23:361\u2013374","journal-title":"Immunity"},{"key":"12_CR302","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/1097-0215(20000520)89:3<305::AID-IJC15>3.0.CO;2-8","volume":"89","author":"F Richard","year":"2000","unstructured":"Richard F, Pacyna-Gengelbach M, Schl\u00fcns K, Fleige B, Winzer KJ, Szymas J, Dietel M, Petersen I, Schwendel A (2000) Patterns of chromosomal imbalances in invasive breast cancer. Int J Cancer 89:305\u2013310","journal-title":"Int J Cancer"},{"key":"12_CR303","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.1073\/pnas.94.16.8569","volume":"94","author":"N Ringstad","year":"1997","unstructured":"Ringstad N, Nemoto Y, De Camilli P (1997) The SH3p4\/Sh3p8\/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. Proc Natl Acad Sci U S A 94:8569\u20138574","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"12_CR1000","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0165-4608(03)00188-2","volume":"147","author":"M Risio","year":"2003","unstructured":"Risio M, Casorzo L, et al (2003) Deletions of 17p are associated with transition from early to advanced colorectal cancer. Cancer Gene Cytogenet 147(1):44\u201349","journal-title":"Cancer Gene Cytogenet"},{"key":"12_CR304","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1091\/mbc.10.7.2235","volume":"10","author":"MP Rivas","year":"1999","unstructured":"Rivas MP, Kearns BG, Xie Z, Guo S, Sekar MC, Hosaka K, Kagiwada S, York JD, Bankaitis VA (1999) Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to \u201cBypass Sec14p\u201d and inositol auxotrophy. Mol Biol Cell 10:2235\u20132250","journal-title":"Mol Biol Cell"},{"key":"12_CR305","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1365-2958.2011.07639.x","volume":"80","author":"I Rodr\u00edguez-Escudero","year":"2011","unstructured":"Rodr\u00edguez-Escudero I, Ferrer NL, Rotger R, Cid VJ, Molina M (2011) Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication. Mol Microbiol 80:1220\u20131240","journal-title":"Mol Microbiol"},{"key":"12_CR306","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jnr.22236","volume":"88","author":"AG Rodriguez-Gabin","year":"2010","unstructured":"Rodriguez-Gabin AG, Ortiz E, Demoliner K, Si Q, Almazan G, Larocca JN (2010) Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptors. J Neurosci Res 88:589\u2013604","journal-title":"J Neurosci Res"},{"key":"12_CR307","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.4049\/jimmunol.180.6.3689","volume":"180","author":"K Roget","year":"2008","unstructured":"Roget K, Malissen M, Malbec O, Malissen B, Da\u00ebron M (2008) Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells. J Immunol 180:3689\u20133698","journal-title":"J Immunol"},{"key":"12_CR308","doi-asserted-by":"crossref","first-page":"52689","DOI":"10.1074\/jbc.M307983200","volume":"278","author":"HM Rohde","year":"2003","unstructured":"Rohde HM, Cheong FY, Konrad G, Paiha K, Mayinger P, Boehmelt G (2003) The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex. J Biol Chem 278:52689\u201352699","journal-title":"J Biol Chem"},{"key":"12_CR309","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1101\/gad.14.5.505","volume":"14","author":"LR Rohrschneider","year":"2000","unstructured":"Rohrschneider LR, Fuller JF, Wolf I, Liu Y, Lucas DM (2000) Structure, function, and biology of SHIP proteins. Genes Dev 14:505\u2013520","journal-title":"Genes Dev"},{"key":"12_CR310","doi-asserted-by":"crossref","first-page":"e14174","DOI":"10.1371\/journal.pone.0014174","volume":"5","author":"S Roongapinun","year":"2010","unstructured":"Roongapinun S, Oh S-Y, Wu F, Panthong A, Zheng T, Zhu Z (2010) Role of SHIP-1 in the adaptive immune responses to aeroallergen in the airway. PLoS ONE 5:e14174","journal-title":"PLoS ONE"},{"key":"12_CR311","doi-asserted-by":"crossref","first-page":"19108","DOI":"10.1074\/jbc.273.30.19108","volume":"273","author":"J Roos","year":"1998","unstructured":"Roos J, Kelly RB (1998) Dap160, a neural-specific Eps15 homology and multiple SH3 domain-containing protein that interacts with Drosophila Dynamin. J Biol Chem 273:19108\u201319119","journal-title":"J Biol Chem"},{"key":"12_CR312","doi-asserted-by":"crossref","first-page":"20283","DOI":"10.1016\/S0021-9258(18)54920-6","volume":"266","author":"TS Ross","year":"1991","unstructured":"Ross TS, Jefferson AB, Mitchell CA, Majerus PW (1991) Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase. J Biol Chem 266:20283\u201320289","journal-title":"J Biol Chem"},{"key":"12_CR313","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1091\/mbc.e03-05-0297","volume":"15","author":"SA Rudge","year":"2004","unstructured":"Rudge SA, Anderson DM, Emr SD (2004) Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14\u2013Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell 15:24\u201336","journal-title":"Mol Biol Cell"},{"key":"12_CR314","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.exphem.2010.03.010","volume":"38","author":"J Ruschmann","year":"2010","unstructured":"Ruschmann J, Ho V, Antignano F, Kuroda E, Lam V, Ibaraki M, Snyder K, Kim C, Flavell RA, Kawakami T, Sly L, Turhan AG, Krystal G (2010) Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. Exp Hematol 38(392\u2013402):402 e1","journal-title":"Exp Hematol"},{"key":"12_CR315","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0960-9822(03)00241-0","volume":"13","author":"N Rusk","year":"2003","unstructured":"Rusk N, Le PU, Mariggio S, Guay G, Lurisci C, Nabi IR, Corda D, Symons M (2003) Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis. Curr Biol 13:659\u2013663","journal-title":"Curr Biol"},{"key":"12_CR316","doi-asserted-by":"crossref","unstructured":"Sachs AJ, David SA, Haider NB, Nystuen AM (2009) Patterned neuroprotection in the Inpp4awbl mutant mouse cerebellum correlates with the expression of Eaat4. PLoS ONE 4","DOI":"10.1371\/journal.pone.0008270"},{"key":"12_CR317","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1128\/MCB.17.7.3841","volume":"17","author":"T Sakisaka","year":"1997","unstructured":"Sakisaka T, Itoh T, Miura K, Takenawa T (1997) Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. Mol Cell Biol 17:3841\u20133849","journal-title":"Mol Cell Biol"},{"key":"12_CR318","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","volume":"414","author":"AR Saltiel","year":"2001","unstructured":"Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799\u2013806","journal-title":"Nature"},{"key":"12_CR319","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1200\/JCO.2005.03.2375","volume":"24","author":"M Sanchez-Carbayo","year":"2006","unstructured":"Sanchez-Carbayo M, Socci ND, Lozano J, Saint F, Cordon-Cardo C (2006) Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol 24:778\u2013789","journal-title":"J Clin Oncol"},{"key":"12_CR320","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/iai.35.3.852-860.1982","volume":"35","author":"PJ Sansonetti","year":"1982","unstructured":"Sansonetti PJ, Kopecko DJ, Formal SB (1982) Involvement of a plasmid in the invasive ability of Shigella flexineri. Infect Immun 35:852\u2013860","journal-title":"Infect Immun"},{"key":"12_CR321","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1462-5822.2009.01400.x","volume":"12","author":"M Santic","year":"2010","unstructured":"Santic M, Al-Khodor S, Abu Kwaik Y (2010) Cell biology and molecular ecology of Francisella tularensis. Cell Microbiol 12:129\u2013139","journal-title":"Cell Microbiol"},{"key":"12_CR322","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature09023","volume":"465","author":"J Sasaki","year":"2010","unstructured":"Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T (2010) The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature 465:497\u2013501","journal-title":"Nature"},{"key":"12_CR323","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.plipres.2009.06.001","volume":"48","author":"T Sasaki","year":"2009","unstructured":"Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A (2009) Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res 48:307\u2013343","journal-title":"Prog Lipid Res"},{"key":"12_CR324","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1007\/s001250100645","volume":"44","author":"T Sasaoka","year":"2001","unstructured":"Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M (2001) SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes. Diabetologia 44:1258\u20131267","journal-title":"Diabetologia"},{"key":"12_CR325","doi-asserted-by":"crossref","first-page":"14835","DOI":"10.1074\/jbc.M311534200","volume":"279","author":"T Sasaoka","year":"2004","unstructured":"Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M (2004) SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes. J Biol Chem 279:14835\u201314843","journal-title":"J Biol Chem"},{"key":"12_CR326","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1086\/302443","volume":"65","author":"V Satre","year":"1999","unstructured":"Satre V, Monnier N, Berthoin F, Ayuso C, Joannard A, Jouk P-S, Lopez-Pajares I, Megabarne A, Philippe HJ, Plauchu H, Torres ML, Lunardi J (1999) Characterization of a Germline Mosaicism in families with Lowe syndrome, and identification of seven novel mutations in the OCRL1 gene. Am J Hum Genet 65:68\u201376","journal-title":"Am J Hum Genet"},{"key":"12_CR327","first-page":"4","volume":"2","author":"M Sattler","year":"2003","unstructured":"Sattler M, Griffin JD (2003) Molecular mechanisms of transformation by the BCR-ABL oncogene. Seminars in hematology 40. Supplement 2:4\u201310","journal-title":"Supplement"},{"key":"12_CR328","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1128\/MCB.19.11.7473","volume":"19","author":"M Sattler","year":"1999","unstructured":"Sattler M, Verma S, Byrne CH, Shrikhande G, Winkler T, Algate PA, Rohrschneider LR, Griffin JD (1999) BCR\/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis. Mol Cell Biol 19:7473\u20137480","journal-title":"Mol Cell Biol"},{"key":"12_CR329","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jmb.2008.10.009","volume":"384","author":"D Sbrissa","year":"2008","unstructured":"Sbrissa D, Ikonomov OC, Fenner H, Shisheva A (2008) ArPIKfyve homomeric and heteromeric interactions Scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. J Mol Biol 384:766\u2013779","journal-title":"J Mol Biol"},{"key":"12_CR330","doi-asserted-by":"crossref","first-page":"23878","DOI":"10.1074\/jbc.M611678200","volume":"282","author":"D Sbrissa","year":"2007","unstructured":"Sbrissa D, Ikonomov OC, Fu Z, Ijuin T, Gruenberg J, Takenawa T, Shisheva A (2007) Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. J Biol Chem 282:23878\u201323891","journal-title":"J Biol Chem"},{"key":"12_CR331","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1128\/MCB.24.23.10437-10447.2004","volume":"24","author":"D Sbrissa","year":"2004","unstructured":"Sbrissa D, Ikonomov OC, Strakova J, Dondapati R, Mlak K, Deeb R, Silver R, Shisheva A (2004) A mammalian ortholog of saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Mol Biol Cell 24:10437\u201310447","journal-title":"Mol Biol Cell"},{"key":"12_CR332","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1074\/jbc.M412729200","volume":"280","author":"D Sbrissa","year":"2005","unstructured":"Sbrissa D, Shisheva A (2005) Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway. J Biol Chem 280:7883\u20137889","journal-title":"J Biol Chem"},{"key":"12_CR333","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.febslet.2004.08.052","volume":"576","author":"AC Schmid","year":"2004","unstructured":"Schmid AC, Wise HM, Mitchell CA, Nussbaum R, Woscholski R (2004) Type II phosphoinositide 5-phosphatases have unique sensitivities towardss fatty acid composition and head group phosphorylation. FEBS Lett 576:9\u201313","journal-title":"FEBS Lett"},{"issue":"45","key":"12_CR334","first-page":"48","volume":"32","author":"JF Schneider","year":"2001","unstructured":"Schneider JF, Boltshauser E, Neuhaus TJ, Rauscher C, Martin E (2001) MRI and proton spectroscopy in Lowe syndrome. Neuropediatrics 32(45):48","journal-title":"Neuropediatrics"},{"key":"12_CR335","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/S0960-9822(01)00449-3","volume":"11","author":"M Schorr","year":"2001","unstructured":"Schorr M, Then A, Tahirovic S, Hug N, Mayinger P (2001) The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase. Curr Biol 11:1421\u20131426","journal-title":"Curr Biol"},{"key":"12_CR336","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/bbrc.1998.8564","volume":"247","author":"L-F Seet","year":"1998","unstructured":"Seet L-F, Cho S, Hessel A, Dumont DJ (1998) Molecular cloning of multiple isoforms of synaptojanin 2 and assignment of the gene to mouse chromosome 17A2-3.1. Biochem Biophys Res Commun 247:116\u2013122","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR337","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1158\/1940-6207.CAPR-10-0058","volume":"3","author":"A Sekulic","year":"2010","unstructured":"Sekulic A, Kim SY, Hostetter G, Savage S, Einspahr JG, Prasad A, Sagerman P, Curiel-Lewandrowski C, Krouse R, Bowden GT, Warneke J, Alberts DS, Pittelkow MR, DiCaudo D, Nickoloff BJ, Trent JM, Bittner M (2010) Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma. Cancer Prev Res 3:1277\u20131283","journal-title":"Cancer Prev Res"},{"key":"12_CR338","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1172\/JCI29967","volume":"117","author":"S Severin","year":"2007","unstructured":"Severin S, Gratacap MP, Lenain N, Alvarez L, Hollande E, Penninger JM, Gachet C, Plantavid M, Payrastre B (2007) Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. J Clin Investig 117:944\u2013952","journal-title":"J Clin Investig"},{"key":"12_CR339","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1164\/rccm.200705-781OC","volume":"177","author":"M Sharma","year":"2008","unstructured":"Sharma M, Batra J, Mabalirajan U, Sharma S, Nagarkatti R, Aich J, Sharma SK, Niphadkar PV, Ghosh B (2008) A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma. Am J Respir Crit Care Med 177:712\u2013719","journal-title":"Am J Respir Crit Care Med"},{"key":"12_CR340","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/hmg\/5.10.1667","volume":"5","author":"AM Shearman","year":"1996","unstructured":"Shearman AM, Hudson TJ, Andresen JM, Wu X, Sohn RL, Haluska F, Housman DE, Weiss JS (1996) The gene for Schnyder\u2019s crystalline corneal dystrophy maps to human chromosome 1p34.1\u2013p36. Hum Mol Genet 5:1667\u20131672","journal-title":"Hum Mol Genet"},{"key":"12_CR341","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbrc.2007.02.115","volume":"356","author":"CT Shearn","year":"2007","unstructured":"Shearn CT, Norris FA (2007) Biochemical characterization of the type I inositol polyphosphate 4-phosphatase C2 domain. Biochem Biophys Res Commun 356:255\u2013259","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR342","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/bbrc.2001.5331","volume":"286","author":"CT Shearn","year":"2001","unstructured":"Shearn CT, Walker J, Norris FA (2001) Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type I\u03b1 expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. Biochem Biophys Res Commun 286:119\u2013125","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR343","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1083\/jcb.200505128","volume":"170","author":"H-W Shin","year":"2005","unstructured":"Shin H-W, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M (2005) An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol 170:607\u2013618","journal-title":"J Cell Biol"},{"key":"12_CR344","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000213506","volume":"112","author":"A Shrimpton","year":"2009","unstructured":"Shrimpton A, Hoopes RJ, Knohl S, Hueber P, Reed A, Christie P, Igarashi T, Lee P, Lehman A, White C, Milford D, Sanchez M, Unwin R, Wrong O, Thakker R, Scheinman S (2009) OCRL1 mutations in Dent 2 patients suggest a mechanism for phenotypic variability. Nephron Physiol 112:27\u201336","journal-title":"Nephron Physiol"},{"key":"12_CR345","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.1133427","volume":"314","author":"T Sj\u00f6blom","year":"2006","unstructured":"Sj\u00f6blom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JKV, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314:268\u2013274","journal-title":"Science"},{"key":"12_CR346","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nm1178","volume":"11","author":"MW Sleeman","year":"2005","unstructured":"Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ, Glass DJ (2005) Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med 11:199\u2013205","journal-title":"Nat Med"},{"key":"12_CR347","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1182\/blood-2008-06-166082","volume":"113","author":"LM Sly","year":"2009","unstructured":"Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G (2009) SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood 113:2945\u20132954","journal-title":"Blood"},{"key":"12_CR348","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.exphem.2003.09.011","volume":"31","author":"LM Sly","year":"2003","unstructured":"Sly LM, Rauh MJ, Kalesnikoff J, B\u00fcchse T, Krystal G (2003) SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Exp Hematol 31:1170\u20131181","journal-title":"Exp Hematol"},{"key":"12_CR349","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chom.2009.12.004","volume":"7","author":"K Smith","year":"2010","unstructured":"Smith K, Humphreys D, Hume PJ, Koronakis V (2010) Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation. Cell Host Microbe 7:13\u201324","journal-title":"Cell Host Microbe"},{"key":"12_CR350","doi-asserted-by":"crossref","first-page":"8418","DOI":"10.1073\/pnas.0932692100","volume":"100","author":"T S\u00f8rlie","year":"2003","unstructured":"S\u00f8rlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, L\u00f8nning PE, Brown PO, B\u00f8rresen-Dale A-L, Botstein D (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 100:8418\u20138423","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR351","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1261\/rna.1534709","volume":"15","author":"G Sotiropoulou","year":"2009","unstructured":"Sotiropoulou G, Pampalakis G, Lianidou E, Mourelatos Z (2009) Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA 15:1443\u20131461","journal-title":"RNA"},{"key":"12_CR352","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1002\/j.1460-2075.1996.tb00866.x","volume":"15","author":"CJ Speed","year":"1996","unstructured":"Speed CJ, Little PJ, Hayman JA, Mitchell CA (1996) Underexpression of the 43\u00a0kDa inositol polyphosphate 5-phosphatase is associated with cellular transformation. EMBO J 15:4852\u20134861","journal-title":"EMBO J"},{"key":"12_CR353","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1432-1033.1995.216_c.x","volume":"234","author":"CJ Speed","year":"1995","unstructured":"Speed CJ, Matzaris M, Bird PI, Mitchell CA (1995) Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase. Eur J Biochem 234:216\u2013224","journal-title":"Eur J Biochem"},{"key":"12_CR354","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1242\/jcs.113.14.2631","volume":"113","author":"CJ Speed","year":"2000","unstructured":"Speed CJ, Mitchell CA (2000) Sustained elevation in inositol 1,4,5-trisphosphate results in inhibition of phosphatidylinositol transfer protein activity and chronic depletion of the agonist-sensitive phosphoinositide pool. J Cell Sci 113:2631\u20132638","journal-title":"J Cell Sci"},{"key":"12_CR355","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1242\/jcs.112.5.669","volume":"112","author":"CJ Speed","year":"1999","unstructured":"Speed CJ, Neylon CB, Little PJ, Mitchell CA (1999) Underexpression of the 43\u00a0kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses following endothelin-1 stimulation. J Cell Sci 112:669\u2013679","journal-title":"J Cell Sci"},{"key":"12_CR356","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0002-9440(10)61257-6","volume":"167","author":"RS Stearman","year":"2005","unstructured":"Stearman RS, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA Jr, Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE, Keith RL, Nemenoff RA, Malkinson AM, Geraci MW (2005) Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol 167:1763\u20131775","journal-title":"Am J Pathol"},{"key":"12_CR357","doi-asserted-by":"crossref","first-page":"37718","DOI":"10.1074\/jbc.M008187200","volume":"275","author":"O Steele-Mortimer","year":"2000","unstructured":"Steele-Mortimer O, Knodler LA, Marcus SL, Scheid MP, Goh B, Pfeifer CG, Duronio V, Finlay BB (2000) Activation of Akt\/protein kinase B in epithelial cells by the Salmonella typhimurium effector SigD. J Biol Chem 275:37718\u201337724","journal-title":"J Biol Chem"},{"key":"12_CR358","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1086\/344517","volume":"71","author":"SF Suchy","year":"2002","unstructured":"Suchy SF, Nussbaum RL (2002) The deficiency of PIP2 5-phosphatase in Lowe syndrome affects actin polymerization. Am J Hum Genet 71:1420\u20131427","journal-title":"Am J Hum Genet"},{"key":"12_CR359","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/hmg\/4.12.2245","volume":"4","author":"SF Suchy","year":"1995","unstructured":"Suchy SF, Olivos-Glander IM, Nussbaum RL (1995) Lowe syndrome, a deficiency of a phosphatidyl-inositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus. Hum Mol Genet 4:2245\u20132250","journal-title":"Hum Mol Genet"},{"key":"12_CR360","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1476-5381.2009.00358.x","volume":"158","author":"A Suwa","year":"2009","unstructured":"Suwa A, Yamamoto T, Sawada A, Minoura K, Hosogai N, Tahara A, Kurama T, Shimokawa T, Aramori I (2009) Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol 158:879\u2013887","journal-title":"Br J Pharmacol"},{"key":"12_CR361","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1073\/pnas.0914658107","volume":"107","author":"LE Swan","year":"2010","unstructured":"Swan LE, Tomasini L, Pirruccello M, Lunardi J, De Camilli P (2010) Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1. Proc Natl Acad Sci U S A 107:3511\u20133516","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR362","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1189\/jlb.0804439","volume":"76","author":"JA Swanson","year":"2004","unstructured":"Swanson JA, Hoppe AD (2004) The coordination of signaling during Fc receptor-mediated phagocytosis. J Leukoc Biol 76:1093\u20131103","journal-title":"J Leukoc Biol"},{"key":"12_CR363","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1600-0854.2004.00255.x","volume":"6","author":"S Tahirovic","year":"2005","unstructured":"Tahirovic S, Schorr M, Mayinger P (2005) Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase. Traffic 6:116\u2013130","journal-title":"Traffic"},{"key":"12_CR364","doi-asserted-by":"crossref","first-page":"16155","DOI":"10.1074\/jbc.M109.081901","volume":"285","author":"T Takabayashi","year":"2010","unstructured":"Takabayashi T, Xie MJ, Takeuchi S, Kawasaki M, Yagi H, Okamoto M, Tariqur RM, Malik F, Kuroda K, Kubota C, Fujieda S, Nagano T, Sato M (2010) LL5\u03b2 directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2. J Biol Chem 285:16155\u201316165","journal-title":"J Biol Chem"},{"key":"12_CR365","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1389-1723(04)00265-8","volume":"98","author":"H Takahashi","year":"2004","unstructured":"Takahashi H, Masuda K, Ando T, Kobayashi T, Honda H (2004) Prognostic predictor with multiple fuzzy neural models using expression profiles from DNA microarray for metastases of breast cancer. J Biosci Bioeng 98:193\u2013199","journal-title":"J Biosci Bioeng"},{"key":"12_CR366","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nm752","volume":"8","author":"S Takeshita","year":"2002","unstructured":"Takeshita S, Namba N, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh MJ, Humphries RK, Krystal G, Teitelbaum SL, Ross FP (2002) SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med 8:943\u2013949","journal-title":"Nat Med"},{"key":"12_CR367","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/oxfordjournals.jbchem.a122917","volume":"106","author":"K Takimoto","year":"1989","unstructured":"Takimoto K, Okada M, Nakagawa H (1989) Purification and characterization of membrane-bound inositolpolyphosphate 5-phosphatase. J Biochem 106:684\u2013690","journal-title":"J Biochem"},{"key":"12_CR368","doi-asserted-by":"crossref","first-page":"22523","DOI":"10.1074\/jbc.M501949200","volume":"280","author":"X Tang","year":"2005","unstructured":"Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A (2005) PTEN, but Not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase\/Akt pathway in 3T3-L1 adipocytes. J Biol Chem 280:22523\u201322529","journal-title":"J Biol Chem"},{"key":"12_CR369","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","volume":"7","author":"CM Taniguchi","year":"2006","unstructured":"Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85\u201396","journal-title":"Nat Rev Mol Cell Biol"},{"key":"12_CR370","doi-asserted-by":"crossref","first-page":"11382","DOI":"10.1073\/pnas.0704853104","volume":"104","author":"T Tarasenko","year":"2007","unstructured":"Tarasenko T, Kole HK, Chi AW, Mentink-Kane MM, Wynn TA, Bolland S (2007) T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1\/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A 104:11382\u201311387","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR371","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","volume":"18","author":"BS Taylor","year":"2010","unstructured":"Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL (2010) Integrative genomic profiling of human prostate cancer. Cancer Cell 18:11\u201322","journal-title":"Cancer Cell"},{"key":"12_CR372","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1128\/MCB.20.18.6860-6871.2000","volume":"20","author":"V Taylor","year":"2000","unstructured":"Taylor V, Wong M, Brandts C, Reilly L, Dean NM, Cowsert LM, Moodie S, Stokoe D (2000) 5\u2019 phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells. Mol Cell Biol 20:6860\u20136871","journal-title":"Mol Cell Biol"},{"key":"12_CR373","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ncb854","volume":"4","author":"MR Terebiznik","year":"2002","unstructured":"Terebiznik MR, Vieira OV, Marcus SL, Slade A, Yip CM, Trimble WS, Meyer T, Finlay BB, Grinstein S (2002) Elimination of host cell PtdIns(4,5)P2 by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat Cell Biol 4:766\u2013773","journal-title":"Nat Cell Biol"},{"key":"12_CR374","doi-asserted-by":"crossref","first-page":"e1000480","DOI":"10.1371\/journal.pgen.1000480","volume":"5","author":"JG Trapani","year":"2009","unstructured":"Trapani JG, Obholzer N, Mo W, Brockerhoff SE, Nicolson T (2009) Synaptojanin1 is required for temporal fidelity of synaptic transmission in hair cells. PLoS Genet 5:e1000480","journal-title":"PLoS Genet"},{"key":"12_CR375","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nm1552","volume":"13","author":"CM Trivedi","year":"2007","unstructured":"Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA (2007) Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3\u03b2 activity. Nat Med 13:324\u2013331","journal-title":"Nat Med"},{"key":"12_CR376","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1182\/blood-2004-10-4072","volume":"105","author":"R Trotta","year":"2005","unstructured":"Trotta R, Parihar R, Yu J, Becknell B, Allard JN, Wen J, Ding W, Mao H, Tridandapani S, Carson WE, Caligiuri MA (2005) Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. Blood 105:3011\u20133018","journal-title":"Blood"},{"key":"12_CR377","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(01)00326-9","volume":"105","author":"Y Tsujishita","year":"2001","unstructured":"Tsujishita Y, Guo S, Stolz LE, York JD, Hurley JH (2001) Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. Cell 105:379\u2013389","journal-title":"Cell"},{"key":"12_CR378","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1182\/blood.V98.7.2028","volume":"98","author":"Z Tu","year":"2001","unstructured":"Tu Z, Ninos JM, Ma Z, Wang J-W, Lemos MP, Desponts C, Ghansah T, Howson JM, Kerr WG (2001) Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5\u2032-phosphatase isoform that partners with the Grb2 adapter protein. Blood 98:2028\u20132038","journal-title":"Blood"},{"key":"12_CR379","doi-asserted-by":"crossref","first-page":"18854","DOI":"10.1073\/pnas.0509740102","volume":"102","author":"A Ungewickell","year":"2005","unstructured":"Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW (2005) The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Proc Natl Acad Sci U S A 102:18854\u201318859","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR380","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1073\/pnas.0405664101","volume":"101","author":"A Ungewickell","year":"2004","unstructured":"Ungewickell A, Ward ME, Ungewickell E, Majerus PW (2004) The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin. Proc Natl Acad Sci U S A 101:13501\u201313506","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR381","doi-asserted-by":"crossref","first-page":"13342","DOI":"10.1073\/pnas.96.23.13342","volume":"96","author":"AJ Ungewickell","year":"1999","unstructured":"Ungewickell AJ, Majerus PW (1999) Increased levels of plasma lysosomal enzymes in patients with Lowe syndrome. Proc Natl Acad Sci U S A 96:13342\u201313344","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR382","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","volume":"415","author":"LJ Veer","year":"2002","unstructured":"van\u2019t Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AAM, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530\u2013536","journal-title":"Nature"},{"key":"12_CR383","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0006-291X(02)02894-2","volume":"300","author":"I Vandenbroere","year":"2003","unstructured":"Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I (2003) The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2. Biochem Biophys Res Commun 300:494\u2013500","journal-title":"Biochem Biophys Res Commun"},{"key":"12_CR384","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","volume":"30","author":"J\u00c1F Vara","year":"2004","unstructured":"Vara J\u00c1F, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonz\u00e1lez-Bar\u00f3n M (2004) PI3K\/Akt signalling pathway and cancer. Cancer Treat Rev 30:193\u2013204","journal-title":"Cancer Treat Rev"},{"issue":"24","key":"12_CR385","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1038\/emboj.2011.354","volume":"30","author":"M Vicinanza","year":"2011","unstructured":"Vicinanza M, Di Campli A, Polishchuk E, Santoro M, Di Tullio G, Godi A, Levtchenko E, De Leo MG, Polishchuk R, Sandoval L, Marzolo M, De Matteis MA (2011) OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin. EMBO J 30(24):4970\u20134985","journal-title":"EMBO J"},{"key":"12_CR386","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1073\/pnas.0803756105","volume":"105","author":"SV Voronov","year":"2008","unstructured":"Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G (2008) Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down\u2019s syndrome. Proc Natl Acad Sci U S A 105:9415\u20139420","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR387","doi-asserted-by":"crossref","first-page":"13696","DOI":"10.1073\/pnas.250476397","volume":"97","author":"P Vyas","year":"2000","unstructured":"Vyas P, Norris FA, Joseph R, Majerus PW, Orkin SH (2000) Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A 97:13696\u201313701","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR388","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1128\/MCB.21.5.1633-1646.2001","volume":"21","author":"T Wada","year":"2001","unstructured":"Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M (2001) Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5\u2019-phosphatase catalytic activity. Mol Cell Biol 21:1633\u20131646","journal-title":"Mol Cell Biol"},{"key":"12_CR389","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/jb\/mvr037","volume":"150","author":"F Wang","year":"2011","unstructured":"Wang F, Ijuin T, Itoh T, Takenawa T (2011) Regulation of IGF-1\/PI3K\/Akt signaling by the phosphoinositide phosphatase pharbin. J Biochem 150:83\u201393","journal-title":"J Biochem"},{"key":"12_CR390","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1126\/science.1068438","volume":"295","author":"JW Wang","year":"2002","unstructured":"Wang JW, Howson JM, Ghansah T, Desponts C, Ninos JM, May SL, Nguyen KH, Toyama-Sorimachi N, Kerr WG (2002) Influence of SHIP on the NK repertoire and allogeneic bone marrow transplantation. Science 295:2094\u20132097","journal-title":"Science"},{"key":"12_CR391","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/ijc.11460","volume":"107","author":"S Weber-Mangal","year":"2003","unstructured":"Weber-Mangal S, Sinn H-P, Popp S, Klaes R, Emig R, Bentz M, Mansmann U, Bastert G, Bartram CR, Jauch A (2003) Breast cancer in young women (\u226435\u00a0years): genomic aberrations detected by comparative genomic hybridization. Int J Cancer 107:583\u2013592","journal-title":"Int J Cancer"},{"key":"12_CR392","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.cub.2003.09.056","volume":"13","author":"H-C Wei","year":"2003","unstructured":"Wei H-C, Sanny J, Shu H, Baillie DL, Brill JA, Price JV, Harden N (2003) The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in drosophila. Curr Biol 13:1882\u20131887","journal-title":"Curr Biol"},{"key":"12_CR393","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/eji.201041105","volume":"41","author":"SB Weisser","year":"2011","unstructured":"Weisser SB, McLarren KW, Voglmaier N, van Netten-Thomas CJ, Antov A, Flavell RA, Sly LM (2011) Alternative activation of macrophages by IL-4 requires SHIP degradation. Eur J Immunol 41:1742\u20131753","journal-title":"Eur J Immunol"},{"key":"12_CR394","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ptr.2616","volume":"23","author":"X-Y Wen","year":"2009","unstructured":"Wen X-Y, Wu S-Y, Li Z-Q, Liu Z-Q, Zhang J-J, Wang G-F, Jiang Z-H, Wu; S-G (2009) Ellagitannin (BJA3121), an anti-proliferative natural polyphenol compound, can regulate the expression of MiRNAs in HepG2 cancer cells. Phytotherapy Res 23:778\u2013784","journal-title":"Phytotherapy Res"},{"key":"12_CR395","doi-asserted-by":"crossref","first-page":"11462","DOI":"10.1073\/pnas.201162998","volume":"98","author":"M West","year":"2001","unstructured":"West M, Blanchette C, Dressman H, Huang E, Ishida S, Spang R, Zuzan H, Olson JA, Marks JR, Nevins JR (2001) Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci U S A 98:11462\u201311467","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR396","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cell.2005.03.033","volume":"121","author":"TF Westbrook","year":"2005","unstructured":"Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, DePinho RA, Chin L, Elledge SJ (2005) A genetic screen for candidate tumor suppressors identifies REST. Cell 121:837\u2013848","journal-title":"Cell"},{"key":"12_CR397","doi-asserted-by":"crossref","first-page":"37055","DOI":"10.1074\/jbc.M006244200","volume":"275","author":"JC Whisstock","year":"2000","unstructured":"Whisstock JC, Romero S, Gurung R, Nandurkar H, Ooms LM, Bottomley SP, Mitchell CA (2000) The inositol polyphosphate 5-phosphatases and the apurinic\/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis. J Biol Chem 275:37055\u201337061","journal-title":"J Biol Chem"},{"key":"12_CR398","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1083\/jcb.122.1.79","volume":"122","author":"E Whitters","year":"1993","unstructured":"Whitters E, Cleves A, McGee T, Skinner H, Bankaitis V (1993) SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. J Cell Biol 122:79\u201394","journal-title":"J Cell Biol"},{"key":"12_CR399","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1242\/jcs.014423","volume":"120","author":"C Williams","year":"2007","unstructured":"Williams C, Choudhury R, McKenzie E, Lowe M (2007) Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway. J Cell Sci 120:3941\u20133951","journal-title":"J Cell Sci"},{"key":"12_CR400","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1182\/blood.V93.8.2707","volume":"93","author":"D Wisniewski","year":"1999","unstructured":"Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B (1999) A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Blood 93:2707\u20132720","journal-title":"Blood"},{"key":"12_CR401","doi-asserted-by":"crossref","first-page":"p26","DOI":"10.1159\/000101797","volume":"106","author":"G Wolf","year":"2007","unstructured":"Wolf G, Ziyadeh FN (2007) Cellular and molecular mechanisms of proteinuria in diabetic nephropathy. Nephron Physiol 106:p26\u2013p31","journal-title":"Nephron Physiol"},{"key":"12_CR402","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5483\/BMBRep.2009.42.2.119","volume":"42","author":"Q Xiong","year":"2009","unstructured":"Xiong Q, Deng CY, Chai J, Jiang SW, Xiong YZ, Li FE, Zheng R (2009) Knockdown of endogenous SKIP gene enhanced insulin-induced glycogen synthesis signaling in differentiating C2C12 myoblasts. BMB Reports 42:119\u2013124","journal-title":"BMB Reports"},{"key":"12_CR403","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10735-011-9321-y","volume":"42","author":"C Yan","year":"2011","unstructured":"Yan C, Hongjuan H, Yanjiang X, Zhengbin H, Kai L, Fengwei Z, Jing H, Qiong W (2011) Expression patterns of imprinted gene Inpp 5f-v3 during mouse brain development. J Mol Histol 42:167\u2013173","journal-title":"J Mol Histol"},{"key":"12_CR404","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.devcel.2010.06.007","volume":"19","author":"A Yavari","year":"2010","unstructured":"Yavari A, Nagaraj R, Owusu-Ansah E, Folick A, Ngo K, Hillman T, Call G, Rohatgi R, Scott MP, Banerjee U (2010) Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell 19:54\u201365","journal-title":"Dev Cell"},{"key":"12_CR405","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1210\/en.2005-1309","volume":"147","author":"K Yogo","year":"2006","unstructured":"Yogo K, Mizutamari M, Mishima K, Takenouchi H, Ishida-Kitagawa N, Sasaki T, Takeya T (2006) Src homology 2 (SH2)-containing 5\u2019-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology 147:3307\u20133317","journal-title":"Endocrinology"},{"key":"12_CR406","doi-asserted-by":"crossref","first-page":"451","DOI":"10.4143\/crt.2003.35.5.451","volume":"35","author":"J Yoon","year":"2003","unstructured":"Yoon J, Lee J, Namkoong S, Bae S, Kim Y, Han S, Cho Y, Nam G, Kim C, Seo J, Ahn W (2003) cDNA microarray analysis of gene expression profiles associated with cervical cancer. Cancer Res Treat 35:451\u2013459","journal-title":"Cancer Res Treat"},{"key":"12_CR407","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.immunol.19.1.475","volume":"19","author":"M Yoshida","year":"2001","unstructured":"Yoshida M (2001) Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol 19:475\u2013496","journal-title":"Annu Rev Immunol"},{"key":"12_CR408","doi-asserted-by":"crossref","first-page":"19300","DOI":"10.1073\/pnas.0803992105","volume":"105","author":"J Yu","year":"2008","unstructured":"Yu J, Ryan DG, Getsios S, Oliveira-Fernandes M, Fatima A, Lavker RM (2008) MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proc Natl Acad Sci U S A 105:19300\u201319305","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR409","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/cr.2007.82","volume":"17","author":"Y Yuan","year":"2007","unstructured":"Yuan Y, Gao X, Guo N, Zhang H, Xie Z, Jin M, Li B, Yu L, Jing N (2007) rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells. Cell Res 17:919\u2013932","journal-title":"Cell Res"},{"key":"12_CR410","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.4049\/jimmunol.179.9.6325","volume":"179","author":"TY Zhang","year":"2007","unstructured":"Zhang TY, Daynes RA (2007) Macrophages from 11\u03b2-hydroxysteroid dehydrogenase type 1-deficient mice exhibit an increased sensitivity to lipopolysaccharide stimulation due to TGF-\u03b2-mediated up-regulation of SHIP1 expression. J Immunol 179:6325\u20136335","journal-title":"J Immunol"},{"key":"12_CR411","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1093\/brain\/awn114","volume":"131","author":"X Zhang","year":"2008","unstructured":"Zhang X, Chow CY, Sahenk Z, Shy ME, Meisler MH, Li J (2008) Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration. Brain 131:1990\u20132001","journal-title":"Brain"},{"key":"12_CR412","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1074\/jbc.273.3.1574","volume":"273","author":"X Zhang","year":"1998","unstructured":"Zhang X, Hartz PA, Philip E, Racusen LC, Majerus PW (1998) Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate. J Biol Chem 273:1574\u20131582","journal-title":"J Biol Chem"},{"key":"12_CR413","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1073\/pnas.92.11.4853","volume":"92","author":"X Zhang","year":"1995","unstructured":"Zhang X, Jefferson AB, Auethavekiat V, Majerus PW (1995) The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase. Proc Natl Acad Sci U S A 92:4853\u20134856","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR414","doi-asserted-by":"crossref","first-page":"11075","DOI":"10.1021\/bi9012462","volume":"48","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Wavreille AS, Kunys AR, Pei D (2009) The SH2 domains of inositol polyphosphate 5-phosphatases SHIP1 and SHIP2 have similar ligand specificity but different binding kinetics. Biochemistry 48:11075\u201311083","journal-title":"Biochemistry"},{"key":"12_CR415","doi-asserted-by":"crossref","first-page":"17518","DOI":"10.1073\/pnas.0702275104","volume":"104","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS (2007) Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A 104:17518\u201317523","journal-title":"Proc Natl Acad Sci U S A"},{"key":"12_CR416","first-page":"161","volume":"82","author":"S Zheng","year":"2002","unstructured":"Zheng S, Zhang J, Di X, Xiao Z, Wang D, Li C, He Z, Han N, Guo S, Cheng S, Gao Y (2002) Loss of heterozygosity fine mapping of chromosome 17p13 in transitional cell carcinoma of human urinary bladder. Zhonghua yi xue za zhi 82:161\u2013163","journal-title":"Zhonghua yi xue za zhi"},{"key":"12_CR417","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3748\/wjg.v8.i4.668","volume":"8","author":"CZ Zhou","year":"2002","unstructured":"Zhou CZ, Peng ZH, Zhang F, Qiu GQ, He L (2002) Loss of heterozygosity on long arm of chromosome 22 in sporadic colorectal carcinoma. World J Gastroenterol 8:668\u2013673","journal-title":"World J Gastroenterol"},{"key":"12_CR418","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1046\/j.1365-2958.2001.02230.x","volume":"39","author":"D Zhou","year":"2001","unstructured":"Zhou D, Chen L-M, Hernandez L, Shears SB, Gal\u00e1n JE (2001) A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Mol Microbiol 39:248\u2013260","journal-title":"Mol Microbiol"},{"key":"12_CR419","doi-asserted-by":"crossref","first-page":"8777","DOI":"10.4049\/jimmunol.177.12.8777","volume":"177","author":"P Zhou","year":"2006","unstructured":"Zhou P, Kitaura H, Teitelbaum SL, Krystal G, Ross FP, Takeshita S (2006) SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27. J Immunol 177:8777\u20138784","journal-title":"J Immunol"},{"key":"12_CR420","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1042\/BST0320817","volume":"32","author":"QL Zhou","year":"2004","unstructured":"Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP (2004) Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans 32:817\u2013821","journal-title":"Biochem Soc Trans"},{"key":"12_CR421","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.3748\/wjg.v10.i13.1975","volume":"10","author":"GN Zhu","year":"2004","unstructured":"Zhu GN, Zuo L, Zhou Q, Zhang SM, Zhu HQ, Gui SY, Wang Y (2004) Loss of heterozygosity on chromosome 10q22\u201310q23 and 22q11.2\u201322q12.1 and p53 gene in primary hepatocellular carcinoma. World J Gastroenterol 10:1975\u20131978","journal-title":"World J Gastroenterol"},{"key":"12_CR422","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/CIRCRESAHA.109.208785","volume":"105","author":"W Zhu","year":"2009","unstructured":"Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA (2009) Inpp 5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circ Res 105:1240\u20131247","journal-title":"Circ Res"},{"key":"12_CR423","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1074\/jbc.M608509200","volume":"282","author":"G Zhuang","year":"2007","unstructured":"Zhuang G, Hunter S, Hwang Y, Chen J (2007) Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-kinase-dependent Rac1 activation. J Biol Chem 282:2683\u20132694","journal-title":"J Biol Chem"},{"key":"12_CR424","doi-asserted-by":"crossref","first-page":"16834","DOI":"10.1073\/pnas.0708189104","volume":"104","author":"J Zou","year":"2007","unstructured":"Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW (2007) Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci U S A 104:16834\u201316839","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Current Topics in Microbiology and Immunology","Phosphoinositides and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-007-5025-8_12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T12:49:08Z","timestamp":1714481348000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-94-007-5025-8_12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9789400750241","9789400750258"],"references-count":425,"URL":"https:\/\/doi.org\/10.1007\/978-94-007-5025-8_12","relation":{},"ISSN":["0070-217X"],"issn-type":[{"value":"0070-217X","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"20 October 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}