{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:23:13Z","timestamp":1789438993759,"version":"build-2803163510"},"publisher-location":"Dordrecht","reference-count":49,"publisher":"Springer Netherlands","isbn-type":[{"value":"9789401792448","type":"print"},{"value":"9789401792455","type":"electronic"}],"license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1007\/978-94-017-9245-5_21","type":"book-chapter","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T20:43:33Z","timestamp":1415997813000},"page":"353-365","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The \u03b17 nAChR Selective Agonists as Drug Candidates for Alzheimer\u2019s Disease"],"prefix":"10.1007","author":[{"given":"Huaimeng","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxu","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"issue":"2","key":"21_CR1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0891-0618(02)00100-X","volume":"25","author":"AJ Graham","year":"2003","unstructured":"Graham AJ, Ray MA, Perry EK, Jaros E, Perry RH, Volsen SG, Bose S, Evans N, Lindstrom J (2003) Differential nicotinic acetylcholine receptor subunit expression in the human hippocampus. J Chem Neuroanat 25(2):97\u2013113","journal-title":"J Chem Neuroanat"},{"issue":"2","key":"21_CR2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0022-3565(24)35314-5","volume":"292","author":"GK Lloyd","year":"2000","unstructured":"Lloyd GK, Williams M (2000) Neuronal nicotinic acetylcholine receptors as novel drug targets. J Pharmacol Exp Ther 292(2):461","journal-title":"J Pharmacol Exp Ther"},{"issue":"37","key":"21_CR3","doi-asserted-by":"crossref","first-page":"11554","DOI":"10.1523\/JNEUROSCI.23-37-11554.2003","volume":"23","author":"R Nashmi","year":"2003","unstructured":"Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA (2003) Assembly of \u03b14\u03b22 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J Neurosci 23(37):11554\u201311567","journal-title":"J Neurosci"},{"key":"21_CR4","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1146\/annurev.pharmtox.47.120505.105214","volume":"47","author":"JA Dani","year":"2007","unstructured":"Dani JA, Bertrand D (2007) Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu Rev Pharmacol Toxicol 47:699\u2013729","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"21_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1152\/physrev.00015.2008","volume":"89","author":"EX Albuquerque","year":"2009","unstructured":"Albuquerque EX, Pereira EFR, Alkondon M, Rogers SW (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89(1):73\u2013120","journal-title":"Physiol Rev"},{"issue":"7","key":"21_CR6","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1046\/j.1460-9568.1999.00676.x","volume":"11","author":"A Wevers","year":"1999","unstructured":"Wevers A, Monteggia L, Nowacki S, Bloch W, Sch\u00fctz U, Lindstrom J, Pereira EFR, Eisenberg H, Giacobini E, De Vos RAI (1999) Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer\u2019s disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein. Eur J Neurosci 11(7):2551\u20132565","journal-title":"Eur J Neurosci"},{"issue":"1","key":"21_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1046\/j.1471-4159.2000.0740237.x","volume":"74","author":"ZZ Guan","year":"2000","unstructured":"Guan ZZ, Zhang X, Ravid R, Nordberg A (2000) Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer\u2019s disease. J Neurochem 74(1):237\u2013243","journal-title":"J Neurochem"},{"key":"21_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1034\/j.1600-0404.2000.00306.x","volume":"102","author":"A Wevers","year":"2000","unstructured":"Wevers A, Witter B, Moser N, Burghaus L, Banerjee C, Steinlein OK, Sch\u00fctz U, De Vos RAI, Jansen Steur ENH, Lindstrom J (2000) Classical Alzheimer features and cholinergic dysfunction: towards a unifying hypothesis? Acta Neurol Scand 102:42\u201348","journal-title":"Acta Neurol Scand"},{"issue":"11","key":"21_CR9","doi-asserted-by":"publisher","first-page":"e290","DOI":"10.1371\/journal.pbio.0050290","volume":"5","author":"LM Luheshi","year":"2007","unstructured":"Luheshi LM, Tartaglia GG, Brorsson AC, Pawar AP, Watson IE, Chiti F, Vendruscolo M, Lomas DA, Dobson CM, Crowther DC (2007) Systematic in vivo analysis of the intrinsic determinants of amyloid \u03b2 pathogenicity. PLoS Biol 5(11):e290","journal-title":"PLoS Biol"},{"issue":"8","key":"21_CR10","doi-asserted-by":"publisher","first-page":"4749","DOI":"10.1074\/jbc.R800036200","volume":"284","author":"R Roychaudhuri","year":"2009","unstructured":"Roychaudhuri R, Yang M, Hoshi MM, Teplow DB (2009) Amyloid \u03b2-protein assembly and Alzheimer disease. J Biol Chem 284(8):4749","journal-title":"J Biol Chem"},{"key":"21_CR11","doi-asserted-by":"crossref","unstructured":"Oneill MJ, Murray TK, Lakics V, Visanji NP, Duty S (2002) The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration. Curr Drug Targets CNS Neurol Disord 1 (4):399\u2013411","DOI":"10.2174\/1568007023339166"},{"issue":"1","key":"21_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1113\/jphysiol.2002.035436","volume":"547","author":"F Grassi","year":"2003","unstructured":"Grassi F, Palma E, Tonini R, Amici M, Ballivet M, Eusebi F (2003) Amyloid \u03b21-42 peptide alters the gating of human and mouse \u03b1-bungarotoxin-sensitive nicotinic receptors. J Physiol 547(1):147\u2013157","journal-title":"J Physiol"},{"issue":"28","key":"21_CR13","doi-asserted-by":"publisher","first-page":"25056","DOI":"10.1074\/jbc.M200066200","volume":"277","author":"KT Dineley","year":"2002","unstructured":"Dineley KT, Bell KA, Bui D, Sweatt JD (2002) \u03b2-Amyloid peptide activates \u03b17 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Biol Chem 277(28):25056\u201325061","journal-title":"J Biol Chem"},{"issue":"17","key":"21_CR14","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1523\/JNEUROSCI.23-17-06740.2003","volume":"23","author":"JJ Dougherty","year":"2003","unstructured":"Dougherty JJ, Wu J, Nichols RA (2003) \u03b2-Amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex. J Neurosci 23(17):6740\u20136747","journal-title":"J Neurosci"},{"issue":"34","key":"21_CR15","doi-asserted-by":"publisher","first-page":"31547","DOI":"10.1074\/jbc.M212532200","volume":"278","author":"HY Wang","year":"2003","unstructured":"Wang HY, Li W, Benedetti NJ, Lee DHS (2003) \u03b17 nicotinic acetylcholine receptors mediate \u03b2-amyloid peptide-induced tau protein phosphorylation. J Biol Chem 278(34):31547","journal-title":"J Biol Chem"},{"issue":"6","key":"21_CR16","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1152\/jn.00996.2002","volume":"89","author":"DB Freir","year":"2003","unstructured":"Freir DB, Herron CE (2003) Nicotine enhances the depressive actions of A\u03b21-40 on long-term potentiation in the rat hippocampal CA1 region in vivo. J Neurophysiol 89(6):2917\u20132922","journal-title":"J Neurophysiol"},{"key":"21_CR17","unstructured":"Wildman SS, Marks J, Churchill LJ, Peppiatt CM, Horisberger JD, King BF, Unwin RJ (2005) Molecular interactions between cloned epithelial sodium channels and ATP-gated P2X receptors. FASEB J 19(5):A1177"},{"issue":"6943","key":"21_CR18","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nature01748","volume":"423","author":"A Miyazawa","year":"2003","unstructured":"Miyazawa A, Fujiyoshi Y, Unwin N (2003) Structure and gating mechanism of the acetylcholine receptor pore. Nature 423(6943):949\u2013955","journal-title":"Nature"},{"issue":"2","key":"21_CR19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nrn731","volume":"3","author":"A Karlin","year":"2002","unstructured":"Karlin A (2002) Emerging structure of the nicotinic acetylcholine receptors. Nat Rev Neurosci 3(2):102\u2013114","journal-title":"Nat Rev Neurosci"},{"issue":"11","key":"21_CR20","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1016\/j.biocel.2009.05.015","volume":"41","author":"HR Arias","year":"2009","unstructured":"Arias HR (2009) Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions? Int J Biochem Cell Biol 41(11):2098\u20132108","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"21_CR21","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0197-0186(99)00154-0","volume":"36","author":"HR Arias","year":"2000","unstructured":"Arias HR (2000) Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors. Neurochem Int 36(7):595\u2013645","journal-title":"Neurochem Int"},{"key":"21_CR22","doi-asserted-by":"crossref","unstructured":"Arias HR (2010)\u00a0Molecular interaction of bupropion with nicotinic acetylcholine receptors. J Pediatr Biochem 1(2):185\u2013197","DOI":"10.1055\/s-0036-1586365"},{"issue":"17","key":"21_CR23","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.2174\/138161211796355119","volume":"17","author":"RX Gu","year":"2011","unstructured":"Gu RX, Zhong YQ, Wei DQ (2011) Structural basis of agonist selectivity for different nAChR subtypes: insights from crystal structures, mutation experiments and molecular simulations. Curr Pharm Des 17(17):1652\u20131662","journal-title":"Curr Pharm Des"},{"issue":"3","key":"21_CR24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1023\/A:1008140021426","volume":"15","author":"JE Tondera","year":"2001","unstructured":"Tondera JE, Olesen PH, Hansen JB, Begtrup M, Pettersson I (2001) An improved nicotinic pharmacophore and a stereoselective CoMFA-model for nicotinic agonists acting at the central nicotinic acetylcholine receptors labelled by [3H]-N-methylcarbamylcholine. J Comput Aided Mol Des 15(3):247\u2013258","journal-title":"J Comput Aided Mol Des"},{"issue":"14","key":"21_CR25","doi-asserted-by":"publisher","first-page":"5247","DOI":"10.1016\/j.bmc.2009.05.040","volume":"17","author":"SN Haydar","year":"2009","unstructured":"Haydar SN, Ghiron C, Bettinetti L, Bothmann H, Comery TA, Dunlop J, La Rosa S, Micco I, Pollastrini M, Quinn J (2009) SAR and biological evaluation of SEN12333\/WAY-317538: novel alpha 7 nicotinic acetylcholine receptor agonist. Bioorg Med Chem 17(14):5247\u20135258","journal-title":"Bioorg Med Chem"},{"key":"21_CR26","doi-asserted-by":"crossref","unstructured":"Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T (2010) Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-Fluorophenyl) pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625\/WYE-103914). J Med Chem 53(11):4379\u20134389","DOI":"10.1021\/jm901692q"},{"key":"21_CR27","doi-asserted-by":"crossref","unstructured":"Mullen G, Napier J, Balestra M, DeCory T, Hale G, Macor J, Mack R, Loch Iii J, Wu E, Kover A (2000) (-)-Spiro [1-azabicyclo [2.2. 2] octane-3, 5\u2019-oxazolidin-2\u2019-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the \u03b17 nicotinic acetylcholine receptor. J Med Chem 43(22):4045\u20134050","DOI":"10.1021\/jm000249r"},{"issue":"4","key":"21_CR28","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00213-003-1668-7","volume":"172","author":"M Kampen","year":"2004","unstructured":"Kampen M, Selbach K, Schneider R, Schiegel E, Boess F, Schreiber R (2004) AR-R 17779 improves social recognition in rats by activation of nicotinic a 7 receptors. Psychopharmacology 172(4):375\u2013383","journal-title":"Psychopharmacology"},{"issue":"2","key":"21_CR29","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1124\/jpet.106.118976","volume":"321","author":"FG Boess","year":"2007","unstructured":"Boess FG, De Vry J, Erb C, Flessner T, Hendrix M, Luithle J, Methfessel C, Riedl B, Schnizler K, van der Staay FJ (2007) The novel \u03b17 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo [2.2. 2] oct-3-yl]-7-[2-(methoxy) phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents. J Pharmacol Exp Ther 321(2):716","journal-title":"J Pharmacol Exp Ther"},{"key":"21_CR30","doi-asserted-by":"crossref","unstructured":"Malysz J, Anderson DJ, Gr Nlien JH, Ji J, Bunnelle WH, H Kerud M, Thorin-Hagene K, Ween H, Helfrich R, Hu M (2010)\u00a0In vitro pharmacological characterization of a novel selective \u03b17 neuronal nicotinic acetylcholine receptor agonist ABT-107. J Pharmacol Exp Ther 334(3):863","DOI":"10.1124\/jpet.110.167072"},{"key":"21_CR31","doi-asserted-by":"crossref","unstructured":"Othman AA, Lenz RA, Zhang J, Li J, Awni WM, Dutta S (2011) Single-and multiple-dose pharmacokinetics, safety, and tolerability of the selective \u03b17 neuronal nicotinic receptor agonist, ABT-107, in healthy human volunteers. J Clin Pharmacol 51(4):512","DOI":"10.1177\/0091270010370460"},{"issue":"2","key":"21_CR32","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1124\/jpet.108.150094","volume":"329","author":"R Roncarati","year":"2009","unstructured":"Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, Jow B, Kowal D, Gianfriddo M, Kelley C (2009) Procognitive and neuroprotective activity of a novel \u03b17 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J Pharmacol Exp Ther 329(2):459","journal-title":"J Pharmacol Exp Ther"},{"issue":"7","key":"21_CR33","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.bcp.2009.05.030","volume":"78","author":"TA Hauser","year":"2009","unstructured":"Hauser TA, Kucinski A, Jordan KG, Gatto GJ, Wersinger SR, Hesse RA, Stachowiak EK, Stachowiak MK, Papke RL, Lippiello PM (2009) TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. Biochem Pharmacol 78(7):803\u2013812","journal-title":"Biochem Pharmacol"},{"issue":"16","key":"21_CR34","doi-asserted-by":"publisher","first-page":"4747","DOI":"10.1016\/j.bmcl.2009.06.059","volume":"19","author":"CJ O\u2019Donnell","year":"2009","unstructured":"O\u2019Donnell CJ, Peng L, O\u2019Neill BT, Arnold EP, Mather RJ, Sands SB, Shrikhande A, Lebel LA, Spracklin DK, Nedza FM (2009) Synthesis and SAR studies of 1, 4-diazabicyclo [3.2. 2] nonane phenyl carbamates-subtype selective, high affinity [alpha] 7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19(16):4747\u20134751","journal-title":"Bioorg Med Chem Lett"},{"issue":"4","key":"21_CR35","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1021\/jm049363q","volume":"48","author":"AL Bodnar","year":"2005","unstructured":"Bodnar AL, Cortes-Burgos LA, Cook KK, Dinh DM, Groppi VE, Hajos M, Higdon NR, Hoffmann WE, Hurst RS, Myers JK (2005) Discovery and structure-activity relationship of quinuclidine benzamides as agonists of \u03b17 nicotinic acetylcholine receptors. J Med Chem 48(4):905\u2013908","journal-title":"J Med Chem"},{"issue":"3","key":"21_CR36","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1124\/jpet.104.076968","volume":"312","author":"M Hajos","year":"2005","unstructured":"Hajos M, Hurst RS, Hoffmann WE, Krause M, Wall TM, Higdon NR, Groppi VE (2005) The selective \u03b17 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-azabicyclo [2.2. 2] oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J Pharmacol Exp Ther 312(3):1213","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"21_CR37","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1016\/j.bmcl.2008.04.070","volume":"18","author":"BA Acker","year":"2008","unstructured":"Acker BA, Jacobsen EJ, Rogers BN, Wishka DG, Reitz SC, Piotrowski DW, Myers JK, Wolfe ML, Groppi VE, Thornburgh BA (2008) Discovery of N-[(3R, 5R)-1-azabicyclo [3.2. 1] oct-3-yl] furo [2, 3-c] pyridine-5-carboxamide as an agonist of the [alpha] 7 nicotinic acetylcholine receptor: in vitro and in vivo activity. Bioorg Med Chem Lett 18(12):3611\u20133615","journal-title":"Bioorg Med Chem Lett"},{"issue":"1\u20132","key":"21_CR38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0091-3057(96)00354-1","volume":"57","author":"CA Briggs","year":"1997","unstructured":"Briggs CA, Anderson DJ, Brioni JD, Buccafusco JJ, Buckley MJ, Campbell JE, Decker MW, Donnelly-Roberts D, Elliott RL, Gopalakrishnan M (1997) Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav 57(1\u20132):231\u2013241","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"21_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neulet.2007.01.045","volume":"416","author":"D Feuerbach","year":"2007","unstructured":"Feuerbach D, Nozulak J, Lingenhoehl K, McAllister K, Hoyer D (2007) JN403, in vitro characterization of a novel nicotinic acetylcholine receptor [alpha] 7 selective agonist. Neurosci Lett 416(1):61\u201365","journal-title":"Neurosci Lett"},{"issue":"1","key":"21_CR40","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.neuropharm.2008.08.025","volume":"56","author":"D Feuerbach","year":"2009","unstructured":"Feuerbach D, Lingenhoehl K, Olpe HR, Vassout A, Gentsch C, Chaperon F, Nozulak J, Enz A, Bilbe G, McAllister K (2009) The selective nicotinic acetylcholine receptor [alpha] 7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology 56(1):254\u2013263","journal-title":"Neuropharmacology"},{"issue":"7","key":"21_CR41","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.bcp.2009.07.005","volume":"78","author":"S Sydserff","year":"2009","unstructured":"Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP (2009) Selective [alpha] 7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. Biochem Pharmacol 78(7):880\u2013888","journal-title":"Biochem Pharmacol"},{"key":"21_CR42","unstructured":"Castner SA, Hudzik T, Maier DL, Mrzljak L, Piser T, Smith JS, Widzowski D, Williams GV (2009) A composition comprising (R)-spiro [L-Azabicyclo [2.2. 2] Octane-3, 2\u2019(3\u2019H)-Furo [2, 3-B] Pyridine (AZD0328) and its use in the treatment of Alzheimer\u2019s disease, ADHD or cognitive dysfunction. EP patent 2,120,937"},{"key":"21_CR43","doi-asserted-by":"crossref","unstructured":"Haydar SN, Dunlop J (2010) Neuronal nicotinic acetylcholine receptors-targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer\u2019s disease. Curr Top Med Chem 10(2):144\u2013152","DOI":"10.2174\/156802610790410983"},{"issue":"1","key":"21_CR44","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neuropharm.2007.04.007","volume":"53","author":"G Lopez-Hernandez","year":"2007","unstructured":"Lopez-Hernandez G, Placzek AN, Thinschmidt JS, Lestage P, Trocme-Thibierge C, Morain P, Papke RL (2007) Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons. Neuropharmacology 53(1):134\u2013144","journal-title":"Neuropharmacology"},{"key":"21_CR45","doi-asserted-by":"crossref","unstructured":"Wang HY, Bakshi K, Shen C, Frankfurt M, Trocm\u00e9-Thibierge C, Morain P (2010) S 24795 limits [beta]-Amyloid-[alpha] 7 nicotinic receptor interaction and reduces Alzheimer\u2019s disease-like pathologies. Biol Psychiatry 67(6):522\u2013530","DOI":"10.1016\/j.biopsych.2009.09.031"},{"issue":"1","key":"21_CR46","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1124\/jpet.107.130062","volume":"324","author":"DJ Anderson","year":"2008","unstructured":"Anderson DJ, Bunnelle W, Surber B, Du J, Surowy C, Tribollet E, Marguerat A, Bertrand D, Gopalakrishnan M (2008) [3H]A-585539[(1S,4S)-2, 2-Dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo [2.2. 1] heptane], a novel high-affinity \u03b17 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. J Pharmacol Exp Ther 324(1):179","journal-title":"J Pharmacol Exp Ther"},{"issue":"39","key":"21_CR47","doi-asserted-by":"publisher","first-page":"10578","DOI":"10.1523\/JNEUROSCI.2444-07.2007","volume":"27","author":"RS Bitner","year":"2007","unstructured":"Bitner RS, Bunnelle WH, Anderson DJ, Briggs CA, Buccafusco J, Curzon P, Decker MW, Frost JM, Gronlien JH, Gubbins E (2007) Broad-spectrum efficacy across cognitive domains by \u03b17 nicotinic acetylcholine receptor agonism correlates with activation of ERK1\/2 and CREB phosphorylation pathways. J Neurosci 27(39):10578","journal-title":"J Neurosci"},{"issue":"1","key":"21_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/sj.npp.1301188","volume":"32","author":"P Pichat","year":"2006","unstructured":"Pichat P, Bergis OE, Terranova JP, Urani A, Duarte C, Santucci V, Gueudet C, Voltz C, Steinberg R, Stemmelin J (2006) SSR180711, a novel selective \u03b17 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32(1):17\u201334","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"21_CR49","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.amjopharm.2009.06.003","volume":"7","author":"MN Sabbagh","year":"2009","unstructured":"Sabbagh MN (2009) Drug development for Alzheimer\u2019s disease: where are we now and where are we headed? Am J Geriatr Pharmacother 7(3):167\u2013185","journal-title":"Am J Geriatr Pharmacother"}],"container-title":["Advances in Experimental Medicine and Biology","Advance in Structural Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-94-017-9245-5_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T18:22:53Z","timestamp":1747160573000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-94-017-9245-5_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,12]]},"ISBN":["9789401792448","9789401792455"],"references-count":49,"URL":"https:\/\/doi.org\/10.1007\/978-94-017-9245-5_21","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,12]]},"assertion":[{"value":"12 November 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}