{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T16:56:59Z","timestamp":1775840219129,"version":"3.50.1"},"publisher-location":"Singapore","reference-count":52,"publisher":"Springer Singapore","isbn-type":[{"value":"9789811020407","type":"print"},{"value":"9789811020414","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/978-981-10-2041-4_1","type":"book-chapter","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T21:51:04Z","timestamp":1476222664000},"page":"3-11","source":"Crossref","is-referenced-by-count":6,"title":["Recent Trends in ADPKD Research"],"prefix":"10.1007","author":[{"given":"Yu Bin","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"issue":"5","key":"1_CR1","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/nm.2135","volume":"16","author":"W Bechtel","year":"2010","unstructured":"Bechtel W, McGoohan S, Zeisberg EM, Muller GA, Kalbacher H, Salant DJ, Muller CA, Kalluri R, Zeisberg M (2010) Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med 16(5):544\u2013550. doi: 10.1038\/nm.2135","journal-title":"Nat Med"},{"issue":"5","key":"1_CR2","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1681\/ASN.2010050526","volume":"22","author":"PD Bell","year":"2011","unstructured":"Bell PD, Fitzgibbon W, Sas K, Stenbit AE, Amria M, Houston A, Reichert R, Gilley S, Siegal GP, Bissler J, Bilgen M, Chou PC, Guay-Woodford L, Yoder B, Haycraft CJ, Siroky B (2011) Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis. J Am Soc Nephrol 22(5):839\u2013848. doi: 10.1681\/ASN.2010050526","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"1_CR3","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1093\/ndt\/gfr432","volume":"26","author":"B Buchholz","year":"2011","unstructured":"Buchholz B, Klanke B, Schley G, Bollag G, Tsai J, Kroening S, Yoshihara D, Wallace DP, Kraenzlin B, Gretz N, Hirth P, Eckardt KU, Bernhardt WM (2011) The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis. Nephrol Dial Transplant 26(11):3458\u20133465. doi: 10.1093\/ndt\/gfr432","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"1_CR4","doi-asserted-by":"publisher","first-page":"F905","DOI":"10.1152\/ajprenal.00421.2006","volume":"292","author":"JM Catania","year":"2007","unstructured":"Catania JM, Chen G, Parrish AR (2007) Role of matrix metalloproteinases in renal pathophysiologies. Am J Physiol Renal Physiol 292(3):F905\u2013F911. doi: 10.1152\/ajprenal.00421.2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"9","key":"1_CR5","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1128\/MCB.01259-08","volume":"29","author":"G Distefano","year":"2009","unstructured":"Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB, Germino GG, Pandolfi PP, Boletta A (2009) Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol 29(9):2359\u20132371. doi: 10.1128\/MCB.01259-08","journal-title":"Mol Cell Biol"},{"issue":"2 Pt 1","key":"1_CR6","doi-asserted-by":"crossref","first-page":"C487","DOI":"10.1152\/ajpcell.1995.269.2.C487","volume":"269","author":"J Du","year":"1995","unstructured":"Du J, Wilson PD (1995) Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD. Am J Physiol 269(2 Pt 1):C487\u2013C495","journal-title":"Am J Physiol"},{"issue":"1","key":"1_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1056\/NEJMicm0905399","volume":"363","author":"B Ekser","year":"2010","unstructured":"Ekser B, Rigotti P (2010) Images in clinical medicine. Autosomal dominant polycystic kidney disease. N Engl J Med 363(1):71. doi: 10.1056\/NEJMicm0905399","journal-title":"N Engl J Med"},{"issue":"2","key":"1_CR8","doi-asserted-by":"publisher","first-page":"C522","DOI":"10.1152\/ajpcell.00163.2010","volume":"301","author":"J Elliott","year":"2011","unstructured":"Elliott J, Zheleznova NN, Wilson PD (2011) c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation. Am J Physiol Cell Physiol 301(2):C522\u2013C529. doi: 10.1152\/ajpcell.00163.2010","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"1_CR9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.molmed.2014.01.004","volume":"20","author":"SV Fedeles","year":"2014","unstructured":"Fedeles SV, Gallagher AR, Somlo S (2014) Polycystin-1: a master regulator of intersecting cystic pathways. Trends Mol Med 20(5):251\u2013260. doi: 10.1016\/j.molmed.2014.01.004","journal-title":"Trends Mol Med"},{"issue":"6","key":"1_CR10","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1083\/jcb.201111146","volume":"197","author":"FR Garcia-Gonzalo","year":"2012","unstructured":"Garcia-Gonzalo FR, Reiter JF (2012) Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access. J Cell Biol 197(6):697\u2013709. doi: 10.1083\/jcb.201111146","journal-title":"J Cell Biol"},{"issue":"11","key":"1_CR11","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/35099066","volume":"2","author":"B Geiger","year":"2001","unstructured":"Geiger B, Bershadsky A, Pankov R, Yamada KM (2001) Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Nat Rev Mol Cell Biol 2(11):793\u2013805. doi: 10.1038\/35099066","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1_CR12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0272-6386(87)80158-0","volume":"9","author":"JR Gregoire","year":"1987","unstructured":"Gregoire JR, Torres VE, Holley KE, Farrow GM (1987) Renal epithelial hyperplastic and neoplastic proliferation in autosomal dominant polycystic kidney disease. Am J Kidney Dis 9(1):27\u201338","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"1_CR13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/path.2734","volume":"222","author":"S Hassane","year":"2010","unstructured":"Hassane S, Leonhard WN, van der Wal A, Hawinkels LJ, Lantinga-van Leeuwen IS, ten Dijke P, Breuning MH, de Heer E, Peters DJ (2010) Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease. J Pathol 222(1):21\u201331. doi: 10.1002\/path.2734","journal-title":"J Pathol"},{"issue":"12","key":"1_CR14","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/nrg1727","volume":"6","author":"F Hildebrandt","year":"2005","unstructured":"Hildebrandt F, Otto E (2005) Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease? Nat Rev Genet 6(12):928\u2013940. doi: 10.1038\/nrg1727","journal-title":"Nat Rev Genet"},{"issue":"4","key":"1_CR15","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1172\/JCI14099","volume":"109","author":"X Hou","year":"2002","unstructured":"Hou X, Mrug M, Yoder BK, Lefkowitz EJ, Kremmidiotis G, D\u2019Eustachio P, Beier DR, Guay-Woodford LM (2002) Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest 109(4):533\u2013540. doi: 10.1172\/JCI14099","journal-title":"J Clin Invest"},{"issue":"2","key":"1_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/ng0695-151","volume":"10","author":"J Hughes","year":"1995","unstructured":"Hughes J, Ward CJ, Peral B, Aspinwall R, Clark K, San Millan JL, Gamble V, Harris PC (1995) The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains. Nat Genet 10(2):151\u2013160. doi: 10.1038\/ng0695-151","journal-title":"Nat Genet"},{"issue":"10","key":"1_CR17","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1681\/ASN.2011010084","volume":"22","author":"A Karihaloo","year":"2011","unstructured":"Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG (2011) Macrophages promote cyst growth in polycystic kidney disease. J Am Soc Nephrol 22(10):1809\u20131814. doi: 10.1681\/ASN.2011010084","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"1_CR18","first-page":"352","volume":"19","author":"SK Katz","year":"1989","unstructured":"Katz SK, Hakki A, Miller AS, Finkelstein SD (1989) Ultrastructural tubular basement membrane lesions in adult polycystic kidney disease. Ann Clin Lab Sci 19(5):352\u2013359","journal-title":"Ann Clin Lab Sci"},{"key":"1_CR19","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015060634","author":"R Lakhia","year":"2015","unstructured":"Lakhia R, Hajarnis S, Williams D, Aboudehen K, Yheskel M, Xing C, Hatley ME, Torres VE, Wallace DP, Patel V (2015) MicroRNA-21 aggravates cyst growth in a model of polycystic kidney disease. J Am Soc Nephrol. doi: 10.1681\/ASN.2015060634","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"1_CR20","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.trsl.2014.11.003","volume":"165","author":"WB LaRiviere","year":"2015","unstructured":"LaRiviere WB, Irazabal MV, Torres VE (2015) Novel therapeutic approaches to autosomal dominant polycystic kidney disease. Transl Res 165(4):488\u2013498. doi: 10.1016\/j.trsl.2014.11.003","journal-title":"Transl Res"},{"issue":"11","key":"1_CR21","doi-asserted-by":"publisher","first-page":"3714","DOI":"10.1172\/JCI34922","volume":"118","author":"SO Lee","year":"2008","unstructured":"Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N (2008) MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest 118(11):3714\u20133724. doi: 10.1172\/JCI34922","journal-title":"J Clin Invest"},{"issue":"10","key":"1_CR22","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.bbadis.2010.10.008","volume":"1812","author":"X Li","year":"2011","unstructured":"Li X (2011) Epigenetics and autosomal dominant polycystic kidney disease. Biochim Biophys Acta 1812(10):1213\u20131218. doi: 10.1016\/j.bbadis.2010.10.008","journal-title":"Biochim Biophys Acta"},{"issue":"5\u20136","key":"1_CR23","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1242\/dmm.003194","volume":"3","author":"S Mangos","year":"2010","unstructured":"Mangos S, Lam PY, Zhao A, Liu Y, Mudumana S, Vasilyev A, Liu A, Drummond IA (2010) The ADPKD genes pkd1a\/b and pkd2 regulate extracellular matrix formation. Dis Model Mech 3(5\u20136):354\u2013365. doi: 10.1242\/dmm.003194","journal-title":"Dis Model Mech"},{"issue":"11","key":"1_CR24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0011-5029(05)80007-0","volume":"41","author":"JR Martinez","year":"1995","unstructured":"Martinez JR, Grantham JJ (1995) Polycystic kidney disease: etiology, pathogenesis, and treatment. Dis Mon 41(11):693\u2013765","journal-title":"Dis Mon"},{"issue":"1","key":"1_CR25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000013552","volume":"20","author":"T Nakamura","year":"2000","unstructured":"Nakamura T, Ushiyama C, Suzuki S, Ebihara I, Shimada N, Koide H (2000) Elevation of serum levels of metalloproteinase-1, tissue inhibitor of metalloproteinase-1 and type IV collagen, and plasma levels of metalloproteinase-9 in polycystic kidney disease. Am J Nephrol 20(1):32\u201336. doi:13552","journal-title":"Am J Nephrol"},{"issue":"6","key":"1_CR26","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1681\/ASN.2004090800","volume":"17","author":"S Omori","year":"2006","unstructured":"Omori S, Hida M, Fujita H, Takahashi H, Tanimura S, Kohno M, Awazu M (2006) Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease. J Am Soc Nephrol 17(6):1604\u20131614. doi: 10.1681\/ASN.2004090800","journal-title":"J Am Soc Nephrol"},{"issue":"26","key":"1_CR27","doi-asserted-by":"publisher","first-page":"10765","DOI":"10.1073\/pnas.1301693110","volume":"110","author":"V Patel","year":"2013","unstructured":"Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P (2013) miR-17 ~ 92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. Proc Natl Acad Sci U S A 110(26):10765\u201310770. doi: 10.1073\/pnas.1301693110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"1_CR28","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/wdev.152","volume":"3","author":"BM Paul","year":"2014","unstructured":"Paul BM, Vanden Heuvel GB (2014) Kidney: polycystic kidney disease. Wiley Interdiscip Rev Dev Biol 3(6):465\u2013487. doi: 10.1002\/wdev.152","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"1","key":"1_CR29","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ydbio.2007.05.027","volume":"308","author":"F Rae","year":"2007","unstructured":"Rae F, Woods K, Sasmono T, Campanale N, Taylor D, Ovchinnikov DA, Grimmond SM, Hume DA, Ricardo SD, Little MH (2007) Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Dev Biol 308(1):232\u2013246. doi: 10.1016\/j.ydbio.2007.05.027","journal-title":"Dev Biol"},{"issue":"1","key":"1_CR30","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/ndt\/gfq384","volume":"26","author":"C Renken","year":"2011","unstructured":"Renken C, Fischer DC, Kundt G, Gretz N, Haffner D (2011) Inhibition of mTOR with sirolimus does not attenuate progression of liver and kidney disease in PCK rats. Nephrol Dial Transplant 26(1):92\u2013100. doi: 10.1093\/ndt\/gfq384","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"1_CR31","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1086\/316939","volume":"68","author":"S Rossetti","year":"2001","unstructured":"Rossetti S, Strmecki L, Gamble V, Burton S, Sneddon V, Peral B, Roy S, Bakkaloglu A, Komel R, Winearls CG, Harris PC (2001) Mutation analysis of the entire PKD1 gene: genetic and diagnostic implications. Am J Hum Genet 68(1):46\u201363. doi: 10.1086\/316939","journal-title":"Am J Hum Genet"},{"issue":"11","key":"1_CR32","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1093\/hmg\/ddn039","volume":"17","author":"S Shibazaki","year":"2008","unstructured":"Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S (2008) Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17(11):1505\u20131516. doi: 10.1093\/hmg\/ddn039","journal-title":"Hum Mol Genet"},{"issue":"14","key":"1_CR33","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1073\/pnas.0509694103","volume":"103","author":"JM Shillingford","year":"2006","unstructured":"Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T (2006) The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A 103(14):5466\u20135471. doi: 10.1073\/pnas.0509694103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"1_CR34","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1093\/hmg\/ddp165","volume":"18","author":"X Song","year":"2009","unstructured":"Song X, Di Giovanni V, He N, Wang K, Ingram A, Rosenblum ND, Pei Y (2009) Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks. Hum Mol Genet 18(13):2328\u20132343. doi: 10.1093\/hmg\/ddp165","journal-title":"Hum Mol Genet"},{"issue":"1","key":"1_CR35","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1053\/j.gastro.2009.09.005","volume":"138","author":"C Spirli","year":"2010","unstructured":"Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M (2010) ERK1\/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. Gastroenterology 138(1):360\u2013371. e367. 10.1053\/j.gastro.2009.09.005","journal-title":"Gastroenterology"},{"key":"1_CR36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.12659\/MSM.892141","volume":"21","author":"L Sun","year":"2015","unstructured":"Sun L, Zhu J, Wu M, Sun H, Zhou C, Fu L, Xu C, Mei C (2015) Inhibition of MiR-199a-5p reduced cell proliferation in autosomal dominant polycystic kidney disease through targeting CDKN1C. Med Sci Monit 21:195\u2013200. doi:10.12659\/MSM.892141","journal-title":"Med Sci Monit"},{"issue":"7","key":"1_CR37","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1681\/ASN.2007060665","volume":"19","author":"WE Sweeney Jr","year":"2008","unstructured":"Sweeney WE Jr, von Vigier RO, Frost P, Avner ED (2008) Src inhibition ameliorates polycystic kidney disease. J Am Soc Nephrol 19(7):1331\u20131341. doi: 10.1681\/ASN.2007060665","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"1_CR38","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/ki.2012.446","volume":"83","author":"KI Swenson-Fields","year":"2013","unstructured":"Swenson-Fields KI, Vivian CJ, Salah SM, Peda JD, Davis BM, van Rooijen N, Wallace DP, Fields TA (2013) Macrophages promote polycystic kidney disease progression. Kidney Int 83(5):855\u2013864. doi: 10.1038\/ki.2012.446","journal-title":"Kidney Int"},{"issue":"8","key":"1_CR39","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1681\/ASN.2013091026","volume":"25","author":"JJ Talbot","year":"2014","unstructured":"Talbot JJ, Song X, Wang X, Rinschen MM, Doerr N, LaRiviere WB, Schermer B, Pei YP, Torres VE, Weimbs T (2014) The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation. J Am Soc Nephrol 25(8):1737\u20131748. doi: 10.1681\/ASN.2013091026","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"1_CR40","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.bbadis.2011.03.002","volume":"1812","author":"YC Tan","year":"2011","unstructured":"Tan YC, Blumenfeld J, Rennert H (2011) Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs. Biochim Biophys Acta 1812(10):1202\u20131212. doi: 10.1016\/j.bbadis.2011.03.002","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"1_CR41","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1681\/ASN.2004080660","volume":"16","author":"Y Tao","year":"2005","unstructured":"Tao Y, Kim J, Schrier RW, Edelstein CL (2005) Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. J Am Soc Nephrol 16(1):46\u201351. doi: 10.1681\/ASN.2004080660","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"1_CR42","doi-asserted-by":"publisher","first-page":"F1463","DOI":"10.1152\/ajprenal.90266.2008","volume":"295","author":"DP Wallace","year":"2008","unstructured":"Wallace DP, Quante MT, Reif GA, Nivens E, Ahmed F, Hempson SJ, Blanco G, Yamaguchi T (2008) Periostin induces proliferation of human autosomal dominant polycystic kidney cells through alphaV-integrin receptor. Am J Physiol Renal Physiol 295(5):F1463\u2013F1471. doi: 10.1152\/ajprenal.90266.2008","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"1_CR43","doi-asserted-by":"publisher","first-page":"F1423","DOI":"10.1152\/ajprenal.00275.2007","volume":"293","author":"T Weimbs","year":"2007","unstructured":"Weimbs T (2007) Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1. Am J Physiol Renal Physiol 293(5):F1423\u2013F1432. doi: 10.1152\/ajprenal.00275.2007","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"1_CR44","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1681\/ASN.2011030284","volume":"22","author":"T Weimbs","year":"2011","unstructured":"Weimbs T (2011) Third-hit signaling in renal cyst formation. J Am Soc Nephrol 22(5):793\u2013795. doi: 10.1681\/ASN.2011030284","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"1_CR45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000020592","volume":"7","author":"PD Wilson","year":"1999","unstructured":"Wilson PD, Burrow CR (1999) Cystic diseases of the kidney: role of adhesion molecules in normal and abnormal tubulogenesis. Exp Nephrol 7(2):114\u2013124. doi:20592","journal-title":"Exp Nephrol"},{"key":"1_CR46","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000425085","volume":"118","author":"PD Wilson","year":"1996","unstructured":"Wilson PD, Norman JT, Kuo NT, Burrow CR (1996) Abnormalities in extracellular matrix regulation in autosomal dominant polycystic kidney disease. Contrib Nephrol 118:126\u2013134","journal-title":"Contrib Nephrol"},{"issue":"10","key":"1_CR47","first-page":"1311","volume":"79","author":"PD Wilson","year":"1999","unstructured":"Wilson PD, Geng L, Li X, Burrow CR (1999) The PKD1 gene product, \u201cpolycystin-1,\u201d is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia. Lab Invest 79(10):1311\u20131323","journal-title":"Lab Invest"},{"issue":"1","key":"1_CR48","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/71724","volume":"24","author":"G Wu","year":"2000","unstructured":"Wu G, Markowitz GS, Li L, D\u2019Agati VD, Factor SM, Geng L, Tibara S, Tuchman J, Cai Y, Park JH, van Adelsberg J, Hou H Jr, Kucherlapati R, Edelmann W, Somlo S (2000) Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet 24(1):75\u201378. doi: 10.1038\/71724","journal-title":"Nat Genet"},{"issue":"5","key":"1_CR49","doi-asserted-by":"publisher","first-page":"F944","DOI":"10.1152\/ajprenal.00387.2010","volume":"299","author":"T Yamaguchi","year":"2010","unstructured":"Yamaguchi T, Reif GA, Calvet JP, Wallace DP (2010) Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol 299(5):F944\u2013F951. doi: 10.1152\/ajprenal.00387.2010","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"1_CR50","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1056\/NEJM199307293290503","volume":"329","author":"M Ye","year":"1993","unstructured":"Ye M, Grantham JJ (1993) The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease. N Engl J Med 329(5):310\u2013313. doi: 10.1056\/NEJM199307293290503","journal-title":"N Engl J Med"},{"issue":"3","key":"1_CR51","doi-asserted-by":"publisher","first-page":"c169","DOI":"10.1159\/000116887","volume":"108","author":"R Zeltner","year":"2008","unstructured":"Zeltner R, Hilgers KF, Schmieder RE, Porst M, Schulze BD, Hartner A (2008) A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Nephron Clin Pract 108(3):c169\u2013c175. doi: 10.1159\/000116887","journal-title":"Nephron Clin Pract"},{"key":"1_CR52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev.physiol.70.113006.100621","volume":"71","author":"J Zhou","year":"2009","unstructured":"Zhou J (2009) Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol 71:83\u2013113. doi: 10.1146\/annurev.physiol.70.113006.100621","journal-title":"Annu Rev Physiol"}],"container-title":["Advances in Experimental Medicine and Biology","Cystogenesis"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-10-2041-4_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T09:28:44Z","timestamp":1568453324000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-981-10-2041-4_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9789811020407","9789811020414"],"references-count":52,"URL":"https:\/\/doi.org\/10.1007\/978-981-10-2041-4_1","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}