{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:43:29Z","timestamp":1790685809382,"version":"4.1.0"},"publisher-location":"Singapore","reference-count":134,"publisher":"Springer Singapore","isbn-type":[{"value":"9789811077562","type":"print"},{"value":"9789811077579","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-981-10-7757-9_11","type":"book-chapter","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T01:43:30Z","timestamp":1519091010000},"page":"329-352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Ryanodine Receptor Structure and Function in Health and Disease"],"prefix":"10.1007","author":[{"given":"Gaetano","family":"Santulli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedee","family":"des Georges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"issue":"27","key":"11_CR1","doi-asserted-by":"publisher","first-page":"11040","DOI":"10.1073\/pnas.0905186106","volume":"106","author":"FJ Amador","year":"2009","unstructured":"Amador FJ, Liu S, Ishiyama N, Plevin MJ, Wilson A, MacLennan DH, Ikura M (2009) Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation \u201chot spot\u201d loop. Proc Natl Acad Sci U S A 106(27):11040\u201311044. https:\/\/doi.org\/10.1073\/pnas.0905186106","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"11_CR2","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.cmet.2011.05.014","volume":"14","author":"DC Andersson","year":"2011","unstructured":"Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, Umanskaya A, Xie W, Shiomi T, Zalk R, Lacampagne A, Marks AR (2011) Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab 14(2):196\u2013207. https:\/\/doi.org\/10.1016\/j.cmet.2011.05.014","journal-title":"Cell Metab"},{"issue":"1","key":"11_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/2044-5040-2-9","volume":"2","author":"DC Andersson","year":"2012","unstructured":"Andersson DC, Meli AC, Reiken S, Betzenhauser MJ, Umanskaya A, Shiomi T, D\u2019Armiento J, Marks AR (2012) Leaky ryanodine receptors in beta-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skelet Muscle 2(1):9. https:\/\/doi.org\/10.1186\/2044-5040-2-9","journal-title":"Skelet Muscle"},{"key":"11_CR4","doi-asserted-by":"publisher","unstructured":"Bai X-C, Yan Z, Wu J, Li Z, Yan N (2016) The central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell Res. https:\/\/doi.org\/10.1038\/cr.2016.89","DOI":"10.1038\/cr.2016.89"},{"issue":"1","key":"11_CR2211","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4081\/ejtm.2015.4803","volume":"25","author":"MR Baker","year":"2015","unstructured":"Baker MR, Fan G, Serysheva II (2015) Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment. Eur J Transl Myol 25(1):35\u201348","journal-title":"Eur J Transl Myol"},{"issue":"20","key":"11_CR2000","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.1073\/pnas.0700814104","volume":"104","author":"RP Baker","year":"2007","unstructured":"Baker RP, Young K, Feng L, Shi Y, Urban S (2007 May 15) Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate. Proc Natl Acad Sci U S A 104(20):8257\u20138262","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"11_CR5","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1172\/JCI34006","volume":"118","author":"AM Bellinger","year":"2008","unstructured":"Bellinger AM, Mongillo M, Marks AR (2008a) Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest 118(2):445\u2013453. https:\/\/doi.org\/10.1172\/JCI34006","journal-title":"J Clin Invest"},{"issue":"6","key":"11_CR6","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1073\/pnas.0711074105","volume":"105","author":"AM Bellinger","year":"2008","unstructured":"Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, Landry DW, Nieman D, Lehnart SE, Samaru M, LaCampagne A, Marks AR (2008b) Remodeling of ryanodine receptor complex causes \u201cleaky\u201d channels: a molecular mechanism for decreased exercise capacity. Proc Natl Acad Sci U S A 105(6):2198\u20132202. https:\/\/doi.org\/10.1073\/pnas.0711074105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"11_CR7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nm.1916","volume":"15","author":"AM Bellinger","year":"2009","unstructured":"Bellinger AM, Reiken S, Carlson C, Mongillo M, Liu X, Rothman L, Matecki S, Lacampagne A, Marks AR (2009) Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat Med 15(3):325\u2013330. https:\/\/doi.org\/10.1038\/nm.1916","journal-title":"Nat Med"},{"issue":"6329","key":"11_CR8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/351751a0","volume":"351","author":"I Bezprozvanny","year":"1991","unstructured":"Bezprozvanny I, Watras J, Ehrlich BE (1991) Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 351(6329):751\u2013754. https:\/\/doi.org\/10.1038\/351751a0","journal-title":"Nature"},{"issue":"1","key":"11_CR9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1161\/01.RES.71.1.18","volume":"71","author":"AM Brillantes","year":"1992","unstructured":"Brillantes AM, Allen P, Takahashi T, Izumo S, Marks AR (1992) Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy. Circ Res 71(1):18\u201326","journal-title":"Circ Res"},{"issue":"4","key":"11_CR10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0092-8674(94)90214-3","volume":"77","author":"AB Brillantes","year":"1994","unstructured":"Brillantes AB, Ondrias K, Scott A, Kobrinsky E, Ondriasova E, Moschella MC, Jayaraman T, Landers M, Ehrlich BE, Marks AR (1994a) Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 77(4):513\u2013523","journal-title":"Cell"},{"issue":"3","key":"11_CR11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.75.3.503","volume":"75","author":"AM Brillantes","year":"1994","unstructured":"Brillantes AM, Bezprozvannaya S, Marks AR (1994b) Developmental and tissue-specific regulation of rabbit skeletal and cardiac muscle calcium channels involved in excitation-contraction coupling. Circ Res 75(3):503\u2013510","journal-title":"Circ Res"},{"issue":"3","key":"11_CR2727","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.jsb.2012.02.003","volume":"177","author":"AF Brilot","year":"2012","unstructured":"Brilot AF, Chen JZ, Cheng A, Pan J, Harrison SC, Potter CS, Carragher B, Henderson R, Grigorieff N (2012, March) Beam-induced motion of vitrified specimen on holey carbon film. J Struct Biol 177(3):630\u2013637. https:\/\/doi.org\/10.1016\/j.jsb.2012.02.003","journal-title":"J Struct Biol"},{"key":"11_CR12","doi-asserted-by":"publisher","unstructured":"Cabra V, Murayama T, Sams\u00f2 M (2016) Ultrastructural analysis of self-associated RyR2s. Biophys J 110(12):2651\u20132662. https:\/\/doi.org\/10.1016\/j.bpj.2016.05.013","DOI":"10.1016\/j.bpj.2016.05.013"},{"issue":"7","key":"11_CR13","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1038\/sj.bjp.0703459","volume":"130","author":"WM Chan","year":"2000","unstructured":"Chan WM, Welch W, Sitsapesan R (2000) Structural factors that determine the ability of adenosine and related compounds to activate the cardiac ryanodine receptor. Br J Pharm 130(7):1618\u20131626. https:\/\/doi.org\/10.1038\/sj.bjp.0703459","journal-title":"Br J Pharm"},{"key":"11_CR14","doi-asserted-by":"publisher","unstructured":"Choi RH, Koenig X, Launikonis BS (2017) Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proc Natl Acad Sci U S A. https:\/\/doi.org\/10.1073\/pnas.1619835114","DOI":"10.1073\/pnas.1619835114"},{"key":"11_CR1212","doi-asserted-by":"crossref","unstructured":"Clarke OB, Hendrickson WA (2016, August) Structures of the colossal RyR1 calcium release channel. Curr Opin Struct Biol 39:144\u2013152. https:\/\/doi.org\/10.1016\/j.sbi.2016.09.002","DOI":"10.1016\/j.sbi.2016.09.002"},{"issue":"49","key":"11_CR3030","doi-asserted-by":"publisher","first-page":"17492","DOI":"10.1073\/pnas.1419276111","volume":"111","author":"A Dashti","year":"2014","unstructured":"Dashti A, Schwander P, Langlois R, Fung R, Li W, Hosseinizadeh A, Liao HY, Pallesen J, Sharma G, Stupina VA, Simon AE, Dinman JD, Frank J, Ourmazd A (2014, December 9) Trajectories of the ribosome as a Brownian nanomachine. Proc Natl Acad Sci U S A 111(49):17492\u201317497. https:\/\/doi.org\/10.1073\/pnas.1419276111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11_CR3333","doi-asserted-by":"crossref","unstructured":"Dashti A, Hail DB, Mashayekhi G, Schwander P, des Georges A, Frank J, Ourmazd A (2017) Conformational Dynamics and Energy Landscapes of Ligand Binding in RyR1. bioRxiv:167080","DOI":"10.1101\/167080"},{"issue":"1","key":"11_CR5656","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cell.2016.08.075","volume":"167","author":"A des Georges","year":"2016","unstructured":"des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J (2016, September 22) Structural basis for gating and activation of RyR1. Cell 167(1):145\u2013157.e17. https:\/\/doi.org\/10.1016\/j.cell.2016.08.075","journal-title":"Cell"},{"issue":"2","key":"11_CR15","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1073\/pnas.1115111108","volume":"109","author":"V Crescenzo De","year":"2012","unstructured":"De Crescenzo V, Fogarty KE, Lefkowitz JJ, Bellve KD, Zvaritch E, MacLennan DH, Walsh JV Jr (2012) Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype. Proc Natl Acad Sci U S A 109(2):610\u2013615. https:\/\/doi.org\/10.1073\/pnas.1115111108","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11_CR2121","doi-asserted-by":"crossref","unstructured":"Dubochet J, Booy FP, Freeman R, Jones AV, Walter CA (1981) Low temperature electron microscopy. Annu Rev Biophys Bioeng 10:133\u2013149","DOI":"10.1146\/annurev.bb.10.060181.001025"},{"key":"11_CR2222","doi-asserted-by":"crossref","unstructured":"Dubochet J, Adrian M, Schultz P, Oudet P (1986, March) Cryo-electron microscopy of vitrified SV40 minichromosomes: the liquid drop model. EMBO J 5(3):519\u2013528","DOI":"10.1002\/j.1460-2075.1986.tb04241.x"},{"issue":"7532","key":"11_CR1717","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature13916","volume":"517","author":"RG Efremov","year":"2015","unstructured":"Efremov RG, Leitner A, Aebersold R, Raunser S (2015, January 1) Architecture and conformational switch mechanism of the ryanodine receptor. Nature 517(7532):39\u201343","journal-title":"Nature"},{"issue":"4","key":"11_CR17","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1152\/physrev.00040.2008","volume":"89","author":"M Endo","year":"2009","unstructured":"Endo M (2009) Calcium-induced calcium release in skeletal muscle. Physiol Rev 89(4):1153\u20131176. https:\/\/doi.org\/10.1152\/physrev.00040.2008","journal-title":"Physiol Rev"},{"issue":"5266","key":"11_CR18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/228034a0","volume":"228","author":"M Endo","year":"1970","unstructured":"Endo M, Tanaka M, Ogawa Y (1970) Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature 228(5266):34\u201336","journal-title":"Nature"},{"issue":"1","key":"11_CR19","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1983.245.1.C1","volume":"245","author":"A Fabiato","year":"1983","unstructured":"Fabiato A (1983) Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Phys 245(1):C1\u201314","journal-title":"Am J Phys"},{"issue":"3","key":"11_CR20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1113\/jphysiol.1975.sp011026","volume":"249","author":"A Fabiato","year":"1975","unstructured":"Fabiato A, Fabiato F (1975) Contractions induced by a calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells. J Physiol 249(3):469\u2013495","journal-title":"J Physiol"},{"issue":"7578","key":"11_CR21","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature15249","volume":"527","author":"G Fan","year":"2015","unstructured":"Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II (2015) Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature 527(7578):336\u2013341. https:\/\/doi.org\/10.1038\/nature15249","journal-title":"Nature"},{"issue":"4","key":"11_CR22","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1073\/pnas.0908540107","volume":"107","author":"J Fauconnier","year":"2010","unstructured":"Fauconnier J, Thireau J, Reiken S, Cassan C, Richard S, Matecki S, Marks AR, Lacampagne A (2010) Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A 107(4):1559\u20131564. https:\/\/doi.org\/10.1073\/pnas.0908540107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"11_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/jmicro\/dfv358","volume":"65","author":"J Frank","year":"2016","unstructured":"Frank J (2016) Generalized single-particle cryo-EM--a historical perspective. Microscopy (Oxf) 65(1):3\u20138. https:\/\/doi.org\/10.1093\/jmicro\/dfv358","journal-title":"Microscopy (Oxf)"},{"key":"11_CR3131","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ymeth.2016.02.007","volume":"100","author":"J Frank","year":"2016","unstructured":"Frank J, Ourmazd A (2016, May 1) Continuous changes in structure mapped by manifold embedding of single-particle data in cryo-EM. Methods 100:61\u201367. https:\/\/doi.org\/10.1016\/j.ymeth.2016.02.007","journal-title":"Methods"},{"issue":"1-2","key":"11_CR2233","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1047-8477(02)00019-9","volume":"138","author":"J Frank","year":"2002","unstructured":"Frank J, Wagenknecht T, McEwen BF, Marko M, Hsieh CE, Mannella CA (2002, April\u2013May) Three-dimensional imaging of biological complexity. J Struct Biol 138(1-2):85\u201391","journal-title":"J Struct Biol"},{"issue":"3","key":"11_CR24","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/S0006-3495(99)77000-1","volume":"77","author":"C Franzini-Armstrong","year":"1999","unstructured":"Franzini-Armstrong C, Protasi F, Ramesh V (1999) Shape, size, and distribution of Ca2+ release units and couplons in skeletal and cardiac muscles. Biophys J 77(3):1528\u20131539","journal-title":"Biophys J"},{"key":"11_CR6060","doi-asserted-by":"crossref","unstructured":"Gambardella J, Trimarco B, Iaccarino G, Santulli G (2017) (in press) New insights in cardiac calcium handling and excitation-contraction coupling. Adv Exp Med Biol. https:\/\/doi.org\/10.1007\/5584_2017_106","DOI":"10.1007\/5584_2017_106"},{"issue":"8","key":"11_CR25","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1021\/bi401586h","volume":"53","author":"AC Gomez","year":"2014","unstructured":"Gomez AC, Yamaguchi N (2014) Two regions of ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation. Biochemistry 53(8):1373\u20131379. https:\/\/doi.org\/10.1021\/bi401586h","journal-title":"Biochemistry"},{"issue":"5","key":"11_CR26","doi-asserted-by":"publisher","first-page":"C749","DOI":"10.1152\/ajpcell.00134.2016","volume":"311","author":"AC Gomez","year":"2016","unstructured":"Gomez AC, Holford TW, Yamaguchi N (2016) Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation. Am J Physiol Cell Physiol 311(5):C749\u2013C757. https:\/\/doi.org\/10.1152\/ajpcell.00134.2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"11_CR27","doi-asserted-by":"crossref","first-page":"e06980","DOI":"10.7554\/eLife.06980","volume":"4","author":"T Grant","year":"2015","unstructured":"Grant T, Grigorieff N (2015) Measuring the optimal exposure for single particle cryo-EM using a 2.6\u00a0\u00c5 reconstruction of rotavirus VP6. Elife 4:e06980","journal-title":"Elife"},{"key":"11_CR28","doi-asserted-by":"publisher","unstructured":"Guo W et al (2016) The EF-hand Ca2+ binding domain is not required for cytosolic Ca2+ activation of the cardiac ryanodine receptor. J Biol Chem. https:\/\/doi.org\/10.1074\/jbc.M115.693325","DOI":"10.1074\/jbc.M115.693325"},{"issue":"2\u20133","key":"11_CR29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(92)80941-9","volume":"312","author":"Y Hakamata","year":"1992","unstructured":"Hakamata Y, Nakai J, Takeshima H, Imoto K (1992) Primary structure and distribution of a novel ryanodine receptor\/calcium release channel from rabbit brain. FEBS Lett 312(2\u20133):229\u2013235","journal-title":"FEBS Lett"},{"key":"11_CR9898","doi-asserted-by":"publisher","unstructured":"Hamilton SL, Serysheva II (2009, February 13) Ryanodine receptor structure: progress and challenges. J Biol Chem 284(7):4047\u20134051. https:\/\/doi.org\/10.1074\/jbc.R800054200 . Epub 2008 Oct 16","DOI":"10.1074\/jbc.R800054200"},{"issue":"6","key":"11_CR30","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1074\/jbc.270.6.2833","volume":"270","author":"DJ Harnick","year":"1995","unstructured":"Harnick DJ, Jayaraman T, Ma Y, Mulieri P, Go LO, Marks AR (1995) The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation. J Biol Chem 270(6):2833\u20132840","journal-title":"J Biol Chem"},{"key":"11_CR31","volume-title":"Ion channels of excitable membranes","author":"B Hille","year":"2001","unstructured":"Hille B (2001) Ion channels of excitable membranes, vol 507. Sinauer, Sunderland"},{"issue":"9","key":"11_CR32","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1073\/pnas.0511282103","volume":"103","author":"F Huang","year":"2006","unstructured":"Huang F, Shan J, Reiken S, Wehrens XH, Marks AR (2006) Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A 103(9):3456\u20133461. https:\/\/doi.org\/10.1073\/pnas.0511282103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"11_CR33","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.molmed.2012.09.006","volume":"18","author":"JH Hwang","year":"2012","unstructured":"Hwang JH, Zorzato F, Clarke NF, Treves S (2012) Mapping domains and mutations on the skeletal muscle ryanodine receptor channel. Trends Mol Med 18(11):644\u2013657. https:\/\/doi.org\/10.1016\/j.molmed.2012.09.006","journal-title":"Trends Mol Med"},{"issue":"4","key":"11_CR34","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/S0021-9258(19)75701-9","volume":"262","author":"M Inui","year":"1987","unstructured":"Inui M, Saito A, Fleischer S (1987) Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle. J Biol Chem 262(4):1740\u20131747","journal-title":"J Biol Chem"},{"key":"11_CR30301","doi-asserted-by":"crossref","unstructured":"Jiang D, Chen W, Wang R, Zhang L, Chen SR (2007, November 13) Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death. Proc Natl Acad Sci U S A 104(46):18309\u201318314","DOI":"10.1073\/pnas.0706573104"},{"key":"11_CR35","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1038\/ncomms2501","volume":"4","author":"L Kimlicka","year":"2013","unstructured":"Kimlicka L, Lau K, Tung CC, Van Petegem F (2013) Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface. Nat Commun 4:1506. https:\/\/doi.org\/10.1038\/ncomms2501","journal-title":"Nat Commun"},{"key":"11_CR36","doi-asserted-by":"crossref","unstructured":"Kushmerick MJ, Moerland TS, Wiseman RW (1992, August 15) Mammalian skeletal muscle fibers distinguished by contents of phosphocreatine, ATP, and Pi. Proc Natl Acad Sci U S A 89(16):7521\u20137525","DOI":"10.1073\/pnas.89.16.7521"},{"issue":"11","key":"11_CR37","doi-asserted-by":"publisher","first-page":"a003996","DOI":"10.1101\/cshperspect.a003996","volume":"2","author":"JT Lanner","year":"2010","unstructured":"Lanner JT, Georgiou DK, Joshi AD, Hamilton SL (2010) Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol 2(11):a003996. https:\/\/doi.org\/10.1101\/cshperspect.a003996","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"11_CR38","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1213\/ane.0000000000000421","volume":"119","author":"MG Larach","year":"2014","unstructured":"Larach MG, Brandom BW, Allen GC, Gronert GA, Lehman EB (2014) Malignant hyperthermia deaths related to inadequate temperature monitoring, 2007\u20132012: a report from the North American malignant hyperthermia registry of the malignant hyperthermia association of the United States. Anesth Analg 119(6):1359\u20131366. https:\/\/doi.org\/10.1213\/ane.0000000000000421","journal-title":"Anesth Analg"},{"key":"11_CR39","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1038\/ncomms6397","volume":"5","author":"K Lau","year":"2014","unstructured":"Lau K, Van Petegem F (2014) Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain. Nat Commun 5:5397. https:\/\/doi.org\/10.1038\/ncomms6397","journal-title":"Nat Commun"},{"issue":"Pt 3","key":"11_CR40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1113\/jphysiol.2001.012775","volume":"537","author":"DR Laver","year":"2001","unstructured":"Laver DR, Lenz GK, Lamb GD (2001) Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine. J Physiol 537(Pt 3):763\u2013778","journal-title":"J Physiol"},{"issue":"12","key":"11_CR41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2174\/1568026033451907","volume":"3","author":"SE Lehnart","year":"2003","unstructured":"Lehnart SE, Huang F, Marx SO, Marks AR (2003) Immunophilins and coupled gating of ryanodine receptors. Cur Top Med Chem 3(12):1383\u20131391","journal-title":"Cur Top Med Chem"},{"issue":"25","key":"11_CR42","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1161\/01.CIR.0000132472.98675.EC","volume":"109","author":"SE Lehnart","year":"2004","unstructured":"Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR (2004) Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation 109(25):3208\u20133214. https:\/\/doi.org\/10.1161\/01.CIR.0000132472.98675.EC","journal-title":"Circulation"},{"issue":"1","key":"11_CR43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cell.2005.07.030","volume":"123","author":"SE Lehnart","year":"2005","unstructured":"Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR (2005) Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell 123(1):25\u201335. https:\/\/doi.org\/10.1016\/j.cell.2005.07.030","journal-title":"Cell"},{"issue":"6","key":"11_CR44","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1172\/JCI35346","volume":"118","author":"SE Lehnart","year":"2008","unstructured":"Lehnart SE, Mongillo M, Bellinger A, Lindegger N, Chen BX, Hsueh W, Reiken S, Wronska A, Drew LJ, Ward CW, Lederer WJ, Kass RS, Morley G, Marks AR (2008) Leaky Ca2+ release channel\/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest 118(6):2230\u20132245. https:\/\/doi.org\/10.1172\/JCI35346","journal-title":"J Clin Invest"},{"key":"11_CR45","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nmeth.2472","volume":"10","author":"X Li","year":"2013","unstructured":"Li X et al (2013) Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods 10:584\u2013590","journal-title":"Nat Methods"},{"key":"11_CR46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature12822","volume":"504","author":"M Liao","year":"2013","unstructured":"Liao M, Cao E, Julius D, Cheng Y (2013) Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature 504:107\u2013112","journal-title":"Nature"},{"key":"11_CR47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jmb.2004.03.011","volume":"338","author":"Z Liu","year":"2004","unstructured":"Liu Z, Zhang J, Wang R, Chen SRW, Wagenknecht T (2004) Location of divergent region 2 on the three-dimensional structure of cardiac muscle ryanodine receptor\/calcium release channel. J Mol Biol 338:533\u2013545","journal-title":"J Mol Biol"},{"issue":"5","key":"11_CR48","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cell.2012.06.052","volume":"150","author":"X Liu","year":"2012","unstructured":"Liu X, Betzenhauser MJ, Reiken S, Meli AC, Xie W, Chen BX, Arancio O, Marks AR (2012) Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell 150(5):1055\u20131067. https:\/\/doi.org\/10.1016\/j.cell.2012.06.052","journal-title":"Cell"},{"issue":"11","key":"11_CR200","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.str.2009.08.016","volume":"17","author":"PA Lobo","year":"2009","unstructured":"Lobo PA, Van Petegem F (2009, November 11) Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure 17(11):1505\u20131514. https:\/\/doi.org\/10.1016\/j.str.2009.08.016","journal-title":"Structure"},{"key":"11_CR5050","doi-asserted-by":"crossref","unstructured":"Lombardi A, Gambardella J, XL D, Sorriento D, Mauro M, Iaccarino G, Trimarco B, Santulli G (2017a, November 20) Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells. Sci Rep 7(1):15823. https:\/\/doi.org\/10.1038\/s41598-017-15283-y","DOI":"10.1038\/s41598-017-15283-y"},{"key":"11_CR5151","doi-asserted-by":"crossref","unstructured":"Lombardi A, Trimarco B, Iaccarino G, Santulli G (2017b, November 13) Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. Cell Commun Signal 15(1):47. https:\/\/doi.org\/10.1186\/s12964-017-0203-0","DOI":"10.1186\/s12964-017-0203-0"},{"issue":"8","key":"11_CR1616","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.str.2005.06.005","volume":"13","author":"SJ Ludtke","year":"2005","unstructured":"Ludtke SJ, Serysheva II, Hamilton SL, Chiu W (2005, August) The pore structure of the closed RyR1 channel. Structure 13(8):1203\u20131211","journal-title":"Structure"},{"issue":"3","key":"11_CR49","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1172\/JCI118462","volume":"97","author":"T Maki","year":"1996","unstructured":"Maki T, Gruver EJ, Davidoff AJ, Izzo N, Toupin D, Colucci W, Marks AR, Marsh JD (1996) Regulation of calcium channel expression in neonatal myocytes by catecholamines. J Clin Invest 97(3):656\u2013663. https:\/\/doi.org\/10.1172\/JCI118462","journal-title":"J Clin Invest"},{"issue":"14","key":"11_CR50","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1056\/NEJMp038141","volume":"349","author":"AR Marks","year":"2003","unstructured":"Marks AR (2003) Sirolimus for the prevention of in-stent restenosis in a coronary artery. New Engl J Med 349(14):1307\u20131309. https:\/\/doi.org\/10.1056\/NEJMp038141","journal-title":"New Engl J Med"},{"issue":"22","key":"11_CR51","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1073\/pnas.86.22.8683","volume":"86","author":"AR Marks","year":"1989","unstructured":"Marks AR, Tempst P, Hwang KS, Taubman MB, Inui M, Chadwick C, Fleischer S, Nadal-Ginard B (1989) Molecular cloning and characterization of the ryanodine receptor\/junctional channel complex cDNA from skeletal muscle sarcoplasmic reticulum. Proc Natl Acad Sci U S A 86(22):8683\u20138687","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"11_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jcp.10031","volume":"190","author":"AR Marks","year":"2002","unstructured":"Marks AR, Priori S, Memmi M, Kontula K, Laitinen PJ (2002) Involvement of the cardiac ryanodine receptor\/calcium release channel in catecholaminergic polymorphic ventricular tachycardia. J Cell Physiol 190(1):1\u20136. https:\/\/doi.org\/10.1002\/jcp.10031","journal-title":"J Cell Physiol"},{"issue":"5378","key":"11_CR53","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.281.5378.818","volume":"281","author":"SO Marx","year":"1998","unstructured":"Marx SO, Ondrias K, Marks AR (1998) Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors). Science 281(5378):818\u2013821","journal-title":"Science"},{"issue":"4","key":"11_CR54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80847-8","volume":"101","author":"SO Marx","year":"2000","unstructured":"Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (2000) PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101(4):365\u2013376","journal-title":"Cell"},{"issue":"11","key":"11_CR55","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/hh1101.091268","volume":"88","author":"SO Marx","year":"2001","unstructured":"Marx SO, Gaburjakova J, Gaburjakova M, Henrikson C, Ondrias K, Marks AR (2001a) Coupled gating between cardiac calcium release channels (ryanodine receptors). Circ Res 88(11):1151\u20131158","journal-title":"Circ Res"},{"issue":"4","key":"11_CR56","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1083\/jcb.153.4.699","volume":"153","author":"SO Marx","year":"2001","unstructured":"Marx SO, Reiken S, Hisamatsu Y, Gaburjakova M, Gaburjakova J, Yang YM, Rosemblit N, Marks AR (2001b) Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine\/isoleucine zippers. J Cell Biol 153(4):699\u2013708","journal-title":"J Cell Biol"},{"issue":"32","key":"11_CR57","doi-asserted-by":"publisher","first-page":"9069","DOI":"10.1073\/pnas.1609707113","volume":"113","author":"S Matecki","year":"2016","unstructured":"Matecki S, Dridi H, Jung B, Saint N, Reiken SR, Scheuermann V, Mrozek S, Santulli G, Umanskaya A, Petrof BJ, Jaber S, Marks AR, Lacampagne A (2016) Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation. Proc Natl Acad Sci U S A 113(32):9069\u20139074. https:\/\/doi.org\/10.1073\/pnas.1609707113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11_CR58","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ultramic.2009.04.002","volume":"109","author":"G McMullan","year":"2009","unstructured":"McMullan G, Chen S, Henderson R, Faruqi AR (2009) Detective quantum efficiency of electron area detectors in electron microscopy. Ultramicroscopy 109:1126\u20131143","journal-title":"Ultramicroscopy"},{"key":"11_CR59","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ultramic.2014.08.002","volume":"147","author":"G McMullan","year":"2014","unstructured":"McMullan G, Faruqi AR, Clare D, Henderson R (2014) Comparison of optimal performance at 300keV of three direct electron detectors for use in low dose electron microscopy. Ultramicroscopy 147:156\u2013163","journal-title":"Ultramicroscopy"},{"issue":"1\u20132","key":"11_CR60","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0014-5793(90)80399-4","volume":"271","author":"J Nakai","year":"1990","unstructured":"Nakai J, Imagawa T, Hakamat Y, Shigekawa M, Takeshima H, Numa S (1990) Primary structure and functional expression from cDNA of the cardiac ryanodine receptor\/calcium release channel. FEBS Lett 271(1\u20132):169\u2013177","journal-title":"FEBS Lett"},{"issue":"1","key":"11_CR61","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(97)01275-1","volume":"417","author":"Y Nakashima","year":"1997","unstructured":"Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T (1997) Molecular cloning and characterization of a human brain ryanodine receptor. FEBS Lett 417(1):157\u2013162","journal-title":"FEBS Lett"},{"issue":"29","key":"11_CR62","doi-asserted-by":"publisher","first-page":"11881","DOI":"10.1073\/pnas.1310571110","volume":"110","author":"BR Nelson","year":"2013","unstructured":"Nelson BR, Wu F, Liu Y, Anderson DM, McAnally J, Lin W, Cannon SC, Bassel-Duby R, Olson EN (2013) Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. Proc Natl Acad Sci U S A 110(29):11881\u201311886. https:\/\/doi.org\/10.1073\/pnas.1310571110","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"11_CR2424","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nmeth.3694","volume":"13","author":"E Nogales","year":"2016","unstructured":"Nogales E (2016, January) The development of cryo-EM into a mainstream structural biology technique. Nat Methods 13(1):24\u201327","journal-title":"Nat Methods"},{"issue":"23","key":"11_CR63","doi-asserted-by":"crossref","first-page":"13472","DOI":"10.1016\/S0021-9258(18)77371-7","volume":"265","author":"K Otsu","year":"1990","unstructured":"Otsu K, Willard HF, Khanna VK, Zorzato F, Green NM, MacLennan DH (1990) Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum. J Biol Chem 265(23):13472\u201313483","journal-title":"J Biol Chem"},{"issue":"38","key":"11_CR64","doi-asserted-by":"publisher","first-page":"34918","DOI":"10.1074\/jbc.M205487200","volume":"277","author":"K Paul-Pletzer","year":"2002","unstructured":"Paul-Pletzer K, Yamamoto T, Bhat MB, Ma J, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Parness J (2002) Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. J Biol Chem 277(38):34918\u201334923. https:\/\/doi.org\/10.1074\/jbc.M205487200","journal-title":"J Biol Chem"},{"key":"11_CR65","doi-asserted-by":"publisher","first-page":"6310","DOI":"10.1126\/science.aah5324","volume":"354","author":"W Peng","year":"2016","unstructured":"Peng W et al (2016) Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science 354:6310. https:\/\/doi.org\/10.1126\/science.aah5324","journal-title":"Science"},{"issue":"4","key":"11_CR66","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.bpj.2011.01.017","volume":"100","author":"M Porta","year":"2011","unstructured":"Porta M, Zima AV, Nani A, Diaz-Sylvester PL, Copello JA, Ramos-Franco J, Blatter LA, Fill M (2011) Single ryanodine receptor channel basis of caffeine\u2019s action on Ca2+ sparks. Biophys J 100(4):931\u2013938. https:\/\/doi.org\/10.1016\/j.bpj.2011.01.017","journal-title":"Biophys J"},{"issue":"1","key":"11_CR67","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/ng0993-51","volume":"5","author":"KA Quane","year":"1993","unstructured":"Quane KA, Healy JM, Keating KE, Manning BM, Couch FJ, Palmucci LM, Doriguzzi C, Fagerlund TH, Berg K, Ording H et al (1993) Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia. Nat Gen 5(1):51\u201355. https:\/\/doi.org\/10.1038\/ng0993-51","journal-title":"Nat Gen"},{"issue":"4","key":"11_CR500","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0006-3495(92)81900-8","volume":"61","author":"M Radermacher","year":"1992","unstructured":"Radermacher M, Wagenknecht T, Grassucci R, Frank J, Inui M, Chadwick C, Fleischer S (1992, April) Cryo-EM of the native structure of the calcium release channel\/ryanodine receptor from sarcoplasmic reticulum. Biophys J 61(4):936\u2013940","journal-title":"Biophys J"},{"issue":"2","key":"11_CR600","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1083\/jcb.127.2.411","volume":"127","author":"M Radermacher","year":"1994","unstructured":"Radermacher M, Rao V, Grassucci R, Frank J, Timerman AP, Fleischer S, Wagenknecht T (1994a, October) Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel\/ryanodine receptor from skeletal muscle. J Cell Biol 127(2):411\u2013423","journal-title":"J Cell Biol"},{"issue":"6106","key":"11_CR68","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/325717a0","volume":"325","author":"E Rios","year":"1987","unstructured":"Rios E, Brum G (1987) Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle. Nature 325(6106):717\u2013720. https:\/\/doi.org\/10.1038\/325717a0","journal-title":"Nature"},{"issue":"2","key":"11_CR69","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/dbio.1998.9120","volume":"206","author":"N Rosemblit","year":"1999","unstructured":"Rosemblit N, Moschella MC, Ondriasova E, Gutstein DE, Ondrias K, Marks AR (1999) Intracellular calcium release channel expression during embryogenesis. Dev Biol 206(2):163\u2013177","journal-title":"Dev Biol"},{"key":"11_CR70","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1750-1172-2-21","volume":"2","author":"H Rosenberg","year":"2007","unstructured":"Rosenberg H, Davis M, James D, Pollock N, Stowell K (2007) Malignant hyperthermia. Orphanet J Rare Dis 2:21\u201321. https:\/\/doi.org\/10.1186\/1750-1172-2-21","journal-title":"Orphanet J Rare Dis"},{"issue":"9","key":"11_CR71","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.healun.2013.06.026","volume":"32","author":"E Rullman","year":"2013","unstructured":"Rullman E, Andersson DC, Melin M, Reiken S, Mancini DM, Marks AR, Lund LH, Gustafsson T (2013) Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure. J Heart Lung Transplant 32(9):925\u2013929. https:\/\/doi.org\/10.1016\/j.healun.2013.06.026","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"11_CR300","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.107.1.211","volume":"107","author":"A Saito","year":"1988","unstructured":"Saito A, Inui M, Radermacher M, Frank J, Fleischer SJ (1988, July) Ultrastructure of the calcium release channel of sarcoplasmic reticulum. Cell Biol 107(1):211\u2013219","journal-title":"Cell Biol"},{"key":"11_CR444","doi-asserted-by":"crossref","unstructured":"Sams\u00f2 M, Wagenknecht T, Allen PD (2005, June) Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. Nat Struct Mol Biol 12(6):539\u2013544","DOI":"10.1038\/nsmb938"},{"key":"11_CR6262","doi-asserted-by":"crossref","unstructured":"Sams\u00f3 M, Feng W, Pessah IN, Allen PD (2009, April 14) Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol 7(4):e85. https:\/\/doi. org\/10.1371\/journal.pbio.1000085","DOI":"10.1371\/journal.pbio.1000085"},{"key":"11_CR72","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-3-319-22380-3_4","volume":"887","author":"G Santulli","year":"2015","unstructured":"Santulli G (2015) microRNAs distinctively regulate vascular smooth muscle and endothelial cells: functional implications in angiogenesis, atherosclerosis, and in-stent restenosis. Adv Exp Med Biol 887:53\u201377. https:\/\/doi.org\/10.1007\/978-3-319-22380-3_4","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"11_CR73","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2174\/1874467208666150507105105","volume":"8","author":"G Santulli","year":"2015","unstructured":"Santulli G, Marks AR (2015) Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging. Curr Mol Pharmacol 8(2):206\u2013222","journal-title":"Curr Mol Pharmacol"},{"issue":"12","key":"11_CR74","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.2217\/pgs.13.143","volume":"14","author":"G Santulli","year":"2013","unstructured":"Santulli G, Totary-Jain H (2013) Tailoring mTOR-based therapy: molecular evidence and clinical challenges. Pharmacogenomics 14(12):1517\u20131526. https:\/\/doi.org\/10.2217\/pgs.13.143","journal-title":"Pharmacogenomics"},{"issue":"9","key":"11_CR75","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1172\/JCI76069","volume":"124","author":"G Santulli","year":"2014","unstructured":"Santulli G, Wronska A, Uryu K, Diacovo TG, Gao M, Marx SO, Kitajewski J, Chilton JM, Akat KM, Tuschl T, Marks AR, Totary-Jain H (2014) A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest 124(9):4102\u20134114. https:\/\/doi.org\/10.1172\/JCI76069","journal-title":"J Clin Invest"},{"issue":"5","key":"11_CR76","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1172\/JCI79273","volume":"125","author":"G Santulli","year":"2015","unstructured":"Santulli G, Pagano G, Sardu C, Xie W, Reiken S, D\u2019Ascia SL, Cannone M, Marziliano N, Trimarco B, Guise TA, Lacampagne A, Marks AR (2015a) Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest 125(5):1968\u20131978. https:\/\/doi.org\/10.1172\/JCI79273","journal-title":"J Clin Invest"},{"issue":"36","key":"11_CR77","doi-asserted-by":"publisher","first-page":"11389","DOI":"10.1073\/pnas.1513047112","volume":"112","author":"G Santulli","year":"2015","unstructured":"Santulli G, Xie W, Reiken SR, Marks AR (2015b) Mitochondrial calcium overload is a key determinant in heart failure. Proc Natl Acad Sci U S A 112(36):11389\u201311394. https:\/\/doi.org\/10.1073\/pnas.1513047112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11_CR78","doi-asserted-by":"publisher","unstructured":"Santulli G, Lewis D, Marks AR (2017a) Physiology and pathophysiology of excitation\u2013contraction coupling in skeletal muscle: the functional role of ryanodine receptor. J Muscle Res Cell Motil. https:\/\/doi.org\/10.1007\/s10974-017-9470-z","DOI":"10.1007\/s10974-017-9470-z"},{"key":"11_CR79","doi-asserted-by":"publisher","unstructured":"Santulli G, Nakashima R, Yuan Q, Marks AR (2017b) Intracellular calcium release channels: an update. J Physiol. https:\/\/doi.org\/10.1113\/JP272781","DOI":"10.1113\/JP272781"},{"issue":"3","key":"11_CR29290","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jsb.2012.09.006","volume":"180","author":"SH Scheres","year":"2012","unstructured":"Scheres SH (2012, December) RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Struct Biol 180(3):519\u2013530. https:\/\/doi.org\/10.1016\/j.jsb.2012.09.006","journal-title":"J Struct Biol"},{"issue":"10","key":"11_CR80","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0960-8966(02)00135-9","volume":"12","author":"CA Sewry","year":"2002","unstructured":"Sewry CA, Muller C, Davis M, Dwyer JS, Dove J, Evans G, Schroder R, Furst D, Helliwell T, Laing N, Quinlivan RC (2002) The spectrum of pathology in central core disease. Neuromusc Disord NMD 12(10):930\u2013938","journal-title":"Neuromusc Disord NMD"},{"issue":"12","key":"11_CR81","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1172\/JCI37649","volume":"120","author":"J Shan","year":"2010","unstructured":"Shan J, Betzenhauser MJ, Kushnir A, Reiken S, Meli AC, Wronska A, Dura M, Chen BX, Marks AR (2010a) Role of chronic ryanodine receptor phosphorylation in heart failure and beta-adrenergic receptor blockade in mice. J Clin Invest 120(12):4375\u20134387. https:\/\/doi.org\/10.1172\/JCI37649","journal-title":"J Clin Invest"},{"issue":"12","key":"11_CR82","doi-asserted-by":"publisher","first-page":"4388","DOI":"10.1172\/JCI32726","volume":"120","author":"J Shan","year":"2010","unstructured":"Shan J, Kushnir A, Betzenhauser MJ, Reiken S, Li J, Lehnart SE, Lindegger N, Mongillo M, Mohler PJ, Marks AR (2010b) Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest 120(12):4388\u20134398. https:\/\/doi.org\/10.1172\/JCI32726","journal-title":"J Clin Invest"},{"issue":"29","key":"11_CR333","doi-asserted-by":"crossref","first-page":"18429","DOI":"10.1074\/jbc.273.29.18429","volume":"273","author":"MR Sharma","year":"1998","unstructured":"Sharma MR, Penczek P, Grassucci R, Xin HB, Fleischer S, Wagenknecht T (1998, July 17) Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor. J Biol Chem 273(29):18429\u201318434","journal-title":"J Biol Chem"},{"issue":"20","key":"11_CR83","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1111\/j.1742-4658.2012.08755.x","volume":"279","author":"P Sharma","year":"2012","unstructured":"Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, MacLennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO (2012) Structural determination of the phosphorylation domain of the ryanodine receptor. FEBS J 279(20):3952\u20133964. https:\/\/doi.org\/10.1111\/j.1742-4658.2012.08755.x","journal-title":"FEBS J"},{"issue":"6","key":"11_CR84","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1161\/circulationaha.111.023259","volume":"124","author":"T Suetomi","year":"2011","unstructured":"Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M (2011) Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca(2)(+)release leading to catecholaminergic polymorphic ventricular tachycardia. Circulation 124(6):682\u2013694. https:\/\/doi.org\/10.1161\/circulationaha.111.023259","journal-title":"Circulation"},{"issue":"6224","key":"11_CR85","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/339439a0","volume":"339","author":"H Takeshima","year":"1989","unstructured":"Takeshima H, Nishimura S, Matsumoto T, Ishida H, Kangawa K, Minamino N, Matsuo H, Ueda M, Hanaoka M, Hirose T et al (1989) Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature 339(6224):439\u2013445. https:\/\/doi.org\/10.1038\/339439a0","journal-title":"Nature"},{"issue":"3","key":"11_CR86","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1093\/cvr\/cvn303","volume":"81","author":"H Tateishi","year":"2009","unstructured":"Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M (2009) Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc Res 81(3):536\u2013545. https:\/\/doi.org\/10.1093\/cvr\/cvn303","journal-title":"Cardiovasc Res"},{"issue":"31","key":"11_CR87","doi-asserted-by":"crossref","first-page":"22992","DOI":"10.1016\/S0021-9258(19)49416-7","volume":"268","author":"AP Timerman","year":"1993","unstructured":"Timerman AP, Ogunbumni E, Freund E, Wiederrecht G, Marks AR, Fleischer S (1993) The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum. J Biol Chem 268(31):22992\u201322999","journal-title":"J Biol Chem"},{"issue":"7323","key":"11_CR88","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature09471","volume":"468","author":"CC Tung","year":"2010","unstructured":"Tung CC, Lobo PA, Kimlicka L, Van Petegem F (2010) The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature 468(7323):585\u2013588. https:\/\/doi.org\/10.1038\/nature09471","journal-title":"Nature"},{"issue":"42","key":"11_CR89","doi-asserted-by":"publisher","first-page":"15250","DOI":"10.1073\/pnas.1412754111","volume":"11","author":"A Umanskaya","year":"2014","unstructured":"Umanskaya A, Santulli G, Xie W, Andersson DC, Reiken SR, Marks AR (2014) Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proc Natl Acad Sci U S A 11(42):15250\u201315255. https:\/\/doi.org\/10.1073\/pnas.1412754111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11_CR90","doi-asserted-by":"crossref","unstructured":"Van Petegem F (2015) Ryanodine receptors: allosteric Ion channel giants. J Mol Biol 427(1):31\u201353. htpps:\/\/doi.org\/10.1016\/j.jmb.2014.08.004","DOI":"10.1016\/j.jmb.2014.08.004"},{"issue":"10","key":"11_CR1818","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/cr.2016.106","volume":"26","author":"F Petegem Van","year":"2016","unstructured":"Van Petegem F (2016, October) How to open a ryanodine receptor. Cell Res 26(10):1073\u20131074","journal-title":"Cell Res"},{"issue":"16","key":"11_CR91","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1161\/01.CIR.0000162461.67140.4C","volume":"111","author":"JA Vest","year":"2005","unstructured":"Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR (2005) Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation 111(16):2025\u20132032. https:\/\/doi.org\/10.1161\/01.CIR.0000162461.67140.4C","journal-title":"Circulation"},{"issue":"6211","key":"11_CR400","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/338167a0","volume":"338","author":"T Wagenknecht","year":"1989","unstructured":"Wagenknecht T, Grassucci R, Frank J, Saito A, Inui M, Fleischer S (1989, March 9) Three-dimensional architecture of the calcium channel\/foot structure of sarcoplasmic reticulum. Nature 338(6211):167\u2013170","journal-title":"Nature"},{"key":"11_CR222","doi-asserted-by":"crossref","unstructured":"Wagenknecht T, Radermacher M (1995, August 1) Three-dimensional architecture of the skeletal muscle ryanodine receptor. FEBS Lett 369(1):43\u201346, Review","DOI":"10.1016\/0014-5793(95)00581-S"},{"key":"11_CR92","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/cr.2016.99","volume":"26","author":"R Wei","year":"2016","unstructured":"Wei R et al (2016) Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1. Cell Res 26:977\u2013994","journal-title":"Cell Res"},{"key":"11_CR93","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.yjmcc.2013.09.003","volume":"64","author":"W Xie","year":"2013","unstructured":"Xie W, Santulli G, Guo X, Gao M, Chen BX, Marks AR (2013) Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol 64:120\u2013123. https:\/\/doi.org\/10.1016\/j.yjmcc.2013.09.003","journal-title":"J Mol Cell Cardiol"},{"key":"11_CR94","doi-asserted-by":"publisher","DOI":"10.1038\/srep11427","volume":"5","author":"W Xie","year":"2015","unstructured":"Xie W, Santulli G, Reiken SR, Yuan Q, Osborne BW, Chen BX, Marks AR (2015) Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep 5:11427. https:\/\/doi.org\/10.1038\/srep11427","journal-title":"Sci Rep"},{"issue":"1","key":"11_CR95","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1006\/bbrc.1995.2283","volume":"214","author":"HB Xin","year":"1995","unstructured":"Xin HB, Timerman AP, Onoue H, Wiederrecht GJ, Fleischer S (1995) Affinity purification of the ryanodine receptor\/calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12. Biochem Biophys Res Commun 214(1):263\u2013270. https:\/\/doi.org\/10.1006\/bbrc.1995.2283","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"11_CR96","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1529\/biophysj.105.066092","volume":"90","author":"L Xiong","year":"2006","unstructured":"Xiong L, Zhang JZ, He R, Hamilton SL (2006) A Ca2+\u2212binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity. Biophys J 90(1):173\u2013182. https:\/\/doi.org\/10.1529\/biophysj.105.066092","journal-title":"Biophys J"},{"issue":"7532","key":"11_CR97","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature14063","volume":"517","author":"Z Yan","year":"2015","unstructured":"Yan Z, Bai X-C, Yan C, Wu J, Li Z, Xie T, Peng W, Yin C-C, Li X, Scheres SHW, Shi Y, Yan N (2015) Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature 517(7532):50\u201355. https:\/\/doi.org\/10.1038\/nature14063","journal-title":"Nature"},{"key":"11_CR98","doi-asserted-by":"publisher","DOI":"10.1038\/srep07425","volume":"4","author":"Q Yuan","year":"2014","unstructured":"Yuan Q, Chen Z, Santulli G, Gu L, Yang ZG, Yuan ZQ, Zhao YT, Xin HB, Deng KY, Wang SQ, Ji G (2014) Functional role of Calstabin2 in age-related cardiac alterations. Sci Rep 4:7425. https:\/\/doi.org\/10.1038\/srep07425","journal-title":"Sci Rep"},{"issue":"30","key":"11_CR99","doi-asserted-by":"publisher","first-page":"8532","DOI":"10.1073\/pnas.1608859113","volume":"113","author":"Q Yuan","year":"2016","unstructured":"Yuan Q, Yang J, Santulli G, Reiken SR, Wronska A, Kim MM, Osborne BW, Lacampagne A, Yin Y, Marks AR (2016) Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS. Proc Natl Acad Sci U S A 113(30):8532\u20138537. https:\/\/doi.org\/10.1073\/pnas.1608859113","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"11_CR100","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.str.2012.04.015","volume":"20","author":"Z Yuchi","year":"2012","unstructured":"Yuchi Z, Lau K, Van Petegem F (2012) Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain. Structure 20(7):1201\u20131211","journal-title":"Structure"},{"key":"11_CR101","doi-asserted-by":"publisher","first-page":"7947","DOI":"10.1038\/ncomms8947","volume":"6","author":"Z Yuchi","year":"2015","unstructured":"Yuchi Z, Yuen SM, Lau K, Underhill AQ, Cornea RL, Fessenden JD, Van Petegem F (2015) Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant. Nat Commun 6:7947. https:\/\/doi.org\/10.1038\/ncomms8947","journal-title":"Nat Commun"},{"key":"11_CR102","doi-asserted-by":"crossref","unstructured":"Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR (2015, January 1) Structure of a mammalian ryanodine receptor. Nature 517(7532):44\u201349","DOI":"10.1038\/nature13950"},{"issue":"1","key":"11_CR103","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/ng0993-46","volume":"5","author":"Y Zhang","year":"1993","unstructured":"Zhang Y, Chen HS, Khanna VK, De Leon S, Phillips MS, Schappert K, Britt BA, Browell AK, MacLennan DH (1993) A mutation in the human ryanodine receptor gene associated with central core disease. Nat Gen 5(1):46\u201350. https:\/\/doi.org\/10.1038\/ng0993-46","journal-title":"Nat Gen"},{"issue":"33","key":"11_CR104","doi-asserted-by":"publisher","first-page":"13653","DOI":"10.1073\/pnas.1103360108","volume":"108","author":"L Zhang","year":"2011","unstructured":"Zhang L, Liu Y, Song F, Zheng H, Hu L, Lu H, Liu P, Hao X, Zhang W, Chen K (2011) Functional SNP in the microRNA-367 binding site in the 3\u2019UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification. Proc Natl Acad Sci U S A 108(33):13653\u201313658. https:\/\/doi.org\/10.1073\/pnas.1103360108","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"11_CR105","doi-asserted-by":"publisher","first-page":"13810","DOI":"10.1074\/jbc.M006104200","volume":"276","author":"F Zhao","year":"2001","unstructured":"Zhao F, Li P, Chen SR, Louis CF, Fruen BR (2001) Dantrolene inhibition of ryanodine receptor Ca2+ release channels molecular mechanism and isoform selectivity. J Pys Chem 276(17):13810\u201313816. https:\/\/doi.org\/10.1074\/jbc.M006104200","journal-title":"J Pys Chem"}],"container-title":["Subcellular Biochemistry","Membrane Protein Complexes: Structure and Function"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-10-7757-9_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T11:22:02Z","timestamp":1660476122000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-981-10-7757-9_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9789811077562","9789811077579"],"references-count":134,"URL":"https:\/\/doi.org\/10.1007\/978-981-10-7757-9_11","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732754805.793552458","asserted-by":"object"}]},"ISSN":["0306-0225"],"issn-type":[{"value":"0306-0225","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}