{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:26:34Z","timestamp":1790389594137,"version":"4.1.0"},"publisher-location":"Singapore","reference-count":155,"publisher":"Springer Singapore","isbn-type":[{"value":"9789811309496","type":"print"},{"value":"9789811309502","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-981-13-0950-2_4","type":"book-chapter","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T10:53:47Z","timestamp":1540378427000},"page":"49-78","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Scaffolds Fabricated from Natural Polymers\/Composites by Electrospinning for Bone Tissue Regeneration"],"prefix":"10.1007","author":[{"given":"Hasham S.","family":"Sofi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roqia","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushtaq A.","family":"Beigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem A.","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1007\/s005860100","volume":"10","author":"T Albrektsson","year":"2001","unstructured":"Albrektsson T, Johansson C (2001) Osteoinduction, osteoconduction and osseointegration. Eur Spine J 10:S96\u2013S101. \nhttps:\/\/doi.org\/10.1007\/s005860100","journal-title":"Eur Spine J"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.msec.2016.09.039","volume":"70","author":"S Aliramaji","year":"2017","unstructured":"Aliramaji S, Zamanian A, Mozafari M (2017) Super-paramagnetic responsive silk fibroin\/chitosan\/magnetite scaffolds with tunable pore structures for bone tissue engineering applications. Mater Sci Eng: C 70:736\u2013744. \nhttps:\/\/doi.org\/10.1016\/j.msec.2016.09.039","journal-title":"Mater Sci Eng: C"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.ijbiomac.2016.12.091","volume":"97","author":"C Ao","year":"2017","unstructured":"Ao C, Niu Y, Zhang X, He X, Zhang W, Lu C (2017) Fabrication and characterization of electrospun cellulose\/nano-hydroxyapatite nanofibers for bone tissue engineering. Int J Biol Macromol 97:568\u2013573. \nhttps:\/\/doi.org\/10.1016\/j.ijbiomac.2016.12.091","journal-title":"Int J Biol Macromol"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1079\/PNS2003268","volume":"62","author":"T Arnett","year":"2003","unstructured":"Arnett T (2003) Regulation of bone cell function by acid\u2013base balance. Proc Nutr Soc 62:511\u2013520. \nhttps:\/\/doi.org\/10.1079\/PNS2003268","journal-title":"Proc Nutr Soc"},{"key":"4_CR5","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.colsurfb.2017.03.034","volume":"154","author":"YE Arslan","year":"2017","unstructured":"Arslan YE, Arslan TS, Derkus B, Emregul E, Emregul KC (2017) Fabrication of human hair keratin\/jellyfish collagen\/eggshell-derived hydroxyapatite osteoinductive biocomposite scaffolds for bone tissue engineering: from waste to regenerative medicine products. Colloids Surf B: Biointerfaces 154:160\u2013170. \nhttps:\/\/doi.org\/10.1016\/j.colsurfb.2017.03.034","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"4","key":"4_CR6","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/term.2563","volume":"12","author":"S. Babitha","year":"2017","unstructured":"Babitha S, Annamalai M, Dykas MM, Saha S, Poddar K, Venugopal JR, Ramakrishna S, Venkatesan T, Korrapati PS (2017) Fabrication of a biomimetic ZeinPDA nanofibrous scaffold impregnated with BMP-2 peptide conjugated TiO2 nanoparticle for bone tissue engineering. J Tissue Eng Regen Med 12(4):991\u2013100. \nhttps:\/\/doi.org\/10.1002\/term.2563","journal-title":"Journal of Tissue Engineering and Regenerative Medicine"},{"key":"4_CR7","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/ni850","volume":"3","author":"G Balciunaite","year":"2002","unstructured":"Balciunaite G, Keller MP, Balciunaite E, Piali L, Zuklys S, Mathieu YD, Gill J, Boyd R, Sussman DJ, Holl\u00e4nder GA (2002) Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol 3:1102\u20131108. \nhttps:\/\/doi.org\/10.1038\/ni850","journal-title":"Nat Immunol"},{"key":"4_CR8","unstructured":"Barr\u00e8re F, van Blitterswijk CA, de Groot K (2006) Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics. Int J Nanomedicine 1(3):317\u2013332"},{"key":"4_CR9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s0044","volume":"363","author":"P Bhattacharjee","year":"2016","unstructured":"Bhattacharjee P, Kundu B, Naskar D, Kim H-W, Bhattacharya D, Maiti T, Kundu S (2016) Potential of inherent RGD containing silk fibroin\u2013poly (\u0404-caprolactone) nanofibrous matrix for bone tissue engineering. Cell Tissue Res 363:525\u2013540. \nhttps:\/\/doi.org\/10.1007\/s0044","journal-title":"Cell Tissue Res"},{"key":"4_CR10","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.eurpolymj.2015.08.025","volume":"71","author":"P Bhattacharjee","year":"2015","unstructured":"Bhattacharjee P, Naskar D, Kim H-W, Maiti TK, Bhattacharya D, Kundu SC (2015) Non-mulberry silk fibroin grafted PCL nanofibrous scaffold: promising ECM for bone tissue engineering. Eur Polym J 71:490\u2013509. \nhttps:\/\/doi.org\/10.1016\/j.eurpolymj.2015.08.025","journal-title":"Eur Polym J"},{"key":"4_CR11","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s40610-015-0022-2","volume":"1","author":"CR Black","year":"2015","unstructured":"Black CR, Goriainov V, Gibbs D, Kanczler J, Tare RS, Oreffo RO (2015) Bone tissue engineering. Curr Mol Biol Rep 1:132\u2013140. \nhttps:\/\/doi.org\/10.1007\/s40610-015-0022-2","journal-title":"Curr Mol Biol Rep"},{"key":"4_CR12","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.tibtech.2012.07.005","volume":"30","author":"S Bose","year":"2012","unstructured":"Bose S, Roy M, Bandyopadhyay A (2012) Recent advances in bone tissue engineering scaffolds. Trends Biotechnol 30:546\u2013554. \nhttps:\/\/doi.org\/10.1016\/j.tibtech.2012.07.005","journal-title":"Trends Biotechnol"},{"key":"4_CR13","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/term.150","volume":"3","author":"O Bretcanu","year":"2009","unstructured":"Bretcanu O, Misra S, Roy I, Renghini C, Fiori F, Boccaccini AR, Salih V (2009) In vitro biocompatibility of 45S5 bioglass\u00ae-derived glass\u2013ceramic scaffolds coated with poly (3-hydroxybutyrate). J Tissue Eng Regen Med 3:139\u2013148. \nhttps:\/\/doi.org\/10.1002\/term.150","journal-title":"J Tissue Eng Regen Med"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nrrheum.2009.228","volume":"5","author":"EM Bueno","year":"2009","unstructured":"Bueno EM, Glowacki J (2009) Cell-free and cell-based approaches for bone regeneration. Nat Rev Rheumatol 5:685\u2013697. \nhttps:\/\/doi.org\/10.1038\/nrrheum.2009.228","journal-title":"Nat Rev Rheumatol"},{"key":"4_CR15","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1016\/S0142-9612(00)00102-2","volume":"21","author":"KJ Burg","year":"2000","unstructured":"Burg KJ, Porter S, Kellam JF (2000) Biomaterial developments for bone tissue engineering. Biomaterials 21:2347\u20132359. \nhttps:\/\/doi.org\/10.1016\/S0142-9612(00)00102-2","journal-title":"Biomaterials"},{"key":"4_CR16","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.bone.2009.09.031","volume":"46","author":"H Cao","year":"2010","unstructured":"Cao H, Kuboyama N (2010) A biodegradable porous composite scaffold of PGA\/\u03b2-TCP for bone tissue engineering. Bone 46:386\u2013395. \nhttps:\/\/doi.org\/10.1016\/j.bone.2009.09.031","journal-title":"Bone"},{"key":"4_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.msec.2017.05.056","volume":"79","author":"L Cao","year":"2017","unstructured":"Cao L, Zhang F, Wang Q, Wu X (2017) Fabrication of chitosan\/graphene oxide polymer nanofiber and its biocompatibility for cartilage tissue engineering. Mater Sci Eng: C 79:697\u2013701. \nhttps:\/\/doi.org\/10.1016\/j.msec.2017.05.056","journal-title":"Mater Sci Eng: C"},{"key":"4_CR18","doi-asserted-by":"publisher","first-page":"29497","DOI":"10.1039\/C4RA17087C","volume":"5","author":"S Chahal","year":"2015","unstructured":"Chahal S, Hussain FSJ, Kumar A, Yusoff MM, MSBA R (2015) Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering. RSC Adv 5:29497\u201329504. \nhttps:\/\/doi.org\/10.1039\/C4RA17087C","journal-title":"RSC Adv"},{"issue":"2","key":"4_CR19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/1616-5195(20020201)2:2<67::AID-MABI67>3.0.CO;2-F","volume":"2","author":"Guoping Chen","year":"2002","unstructured":"Chen G, Ushida T, Tateishi T (2002) Scaffold design for tissue engineering. Macromol Biosci 2:67\u201377 https:\/\/doi.org\/10.1002\/1616-5195(20020201)2:2<67::AIDMABI67>3.0.CO;2-F","journal-title":"Macromolecular Bioscience"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.actbio.2007.01.008","volume":"3","author":"Q-Z Chen","year":"2007","unstructured":"Chen Q-Z, Rezwan K, Fran\u00e7on V, Armitage D, Nazhat SN, Jones FH, Boccaccini AR (2007) Surface functionalization of Bioglass\u00ae-derived porous scaffolds. Acta biomaterialia 3:551\u2013562. \nhttps:\/\/doi.org\/10.1016\/j.actbio.2007.01.008","journal-title":"Acta biomaterialia"},{"key":"4_CR21","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1016\/j.polymer.2008.08.057","volume":"49","author":"BH Cipriano","year":"2008","unstructured":"Cipriano BH, Kota AK, Gershon AL, Laskowski CJ, Kashiwagi T, Bruck HA, Raghavan SR (2008) Conductivity enhancement of carbon nanotube and nanofiber-based polymer nanocomposites by melt annealing. Polymer 49:4846\u20134851. \nhttps:\/\/doi.org\/10.1016\/j.polymer.2008.08.057","journal-title":"Polymer"},{"key":"4_CR22","first-page":"65","volume":"57","author":"D Covey","year":"2008","unstructured":"Covey D, Aaron RK, Born CT, Calhoun JH, Einhorn TA, Hayda R, Levin LS, Mazurek M, Murray C, Powell E (2008) Orthopaedic war injuries: from combat casualty care to definitive treatment: a current review of clinical advances, basic science, and research opportunities. Instr Course Lect 57:65\u201386","journal-title":"Instr Course Lect"},{"key":"4_CR23","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/BF00041724","volume":"6","author":"S Cowin","year":"1976","unstructured":"Cowin S, Hegedus D (1976) Bone remodeling I: theory of adaptive elasticity. J Elast 6:313\u2013326. \nhttps:\/\/doi.org\/10.1007\/BF00041724","journal-title":"J Elast"},{"issue":"1121","key":"4_CR24","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1098\/rstb.1984.0042","volume":"304","author":"J. D. Currey","year":"1984","unstructured":"Currey J (1984) Effects of differences in mineralization on the mechanical properties of bone. Philos Trans R Soc Lond B Biol Sci 304:509\u2013518. \nhttps:\/\/doi.org\/10.1098\/rstb.1984.0042","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"1","key":"4_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12015-008-9013-5","volume":"4","author":"Riccardo d\u2019Aquino","year":"2008","unstructured":"Graziano A, d\u2019Aquino R, Laino G, Papaccio G (2008) Dental pulp stem cells: a promising tool for bone regeneration. Stem Cell Rev 4(1):21\u201326. \nhttps:\/\/doi.org\/10.1007\/s12015-008-9013-5","journal-title":"Stem Cell Reviews"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"6203","DOI":"10.1074\/jbc.M508370200","volume":"281","author":"V Deregowski","year":"2006","unstructured":"Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E (2006) Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt\/\u03b2-catenin but not bone morphogenetic protein signaling. J Biol Chem 281:6203\u20136210. \nhttps:\/\/doi.org\/10.1074\/jbc.M508370200","journal-title":"J Biol Chem"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.biomaterials.2016.07.007","volume":"104","author":"C Dhand","year":"2016","unstructured":"Dhand C, Ong ST, Dwivedi N, Diaz SM, Venugopal JR, Navaneethan B, Fazil MH, Liu S, Seitz V, Wintermantel E (2016) Bio-inspired in situ crosslinking and mineralization of electrospun collagen scaffolds for bone tissue engineering. Biomaterials 104:323\u2013338. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2016.07.007","journal-title":"Biomaterials"},{"key":"4_CR28","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.msec.2016.10.002","volume":"71","author":"H Ding","year":"2017","unstructured":"Ding H, Zhong J, Xu F, Song F, Yin M, Wu Y, Hu Q, Wang J (2017) Establishment of 3D culture and induction of osteogenic differentiation of pre-osteoblasts using wet-collected aligned scaffolds. Mater Sci Eng: C 71:222\u2013230. \nhttps:\/\/doi.org\/10.1016\/j.msec.2016.10.002","journal-title":"Mater Sci Eng: C"},{"key":"4_CR29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0304-3886(95)00041-8","volume":"35","author":"J Doshi","year":"1995","unstructured":"Doshi J, Reneker DH (1995) Electrospinning process and applications of electrospun fibers. J Electrostat 35:151\u2013160. \nhttps:\/\/doi.org\/10.1016\/0304-3886(95)00041-8","journal-title":"J Electrostat"},{"key":"4_CR30","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1186\/s11671-017-2316-1","volume":"12","author":"G-Y Du","year":"2017","unstructured":"Du G-Y, He S-W, Sun C-X, Mi L-D (2017) Bone Morphogenic Protein-2 (rhBMP2)-loaded silk fibroin scaffolds to enhance the Osteoinductivity in bone tissue engineering. Nanoscale Res Lett 12:573. \nhttps:\/\/doi.org\/10.1186\/s11671-017-2316-1","journal-title":"Nanoscale Res Lett"},{"key":"4_CR31","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1002\/jbmr.520","volume":"26","author":"MM Dvorak-Ewell","year":"2011","unstructured":"Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM (2011) Osteoblast extracellular Ca2+\u2212sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res 26:2935\u20132947. \nhttps:\/\/doi.org\/10.1002\/jbmr.520","journal-title":"J Bone Miner Res"},{"key":"4_CR32","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ijbiomac.2016.05.067","volume":"91","author":"J Elango","year":"2016","unstructured":"Elango J, Zhang J, Bao B, Palaniyandi K, Wang S, Wenhui W, Robinson JS (2016) Rheological, biocompatibility and osteogenesis assessment of fish collagen scaffold for bone tissue engineering. Int J Biol Macromol 91:51\u201359. \nhttps:\/\/doi.org\/10.1016\/j.ijbiomac.2016.05.067","journal-title":"Int J Biol Macromol"},{"key":"4_CR33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ijbiomac.2016.05.067","volume":"35","author":"M Farokhi","year":"2014","unstructured":"Farokhi M, Mottaghitalab F, Shokrgozar MA, Ai J, Hadjati J, Azami M (2014) Bio-hybrid silk fibroin\/calcium phosphate\/PLGA nanocomposite scaffold to control the delivery of vascular endothelial growth factor. Mater Sci Eng: C 35:401\u2013410. \nhttps:\/\/doi.org\/10.1016\/j.ijbiomac.2016.05.067","journal-title":"Mater Sci Eng: C"},{"key":"4_CR34","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s10570-016-0867-4","volume":"23","author":"PM Favi","year":"2016","unstructured":"Favi PM, Ospina SP, Kachole M, Gao M, Atehortua L, Webster TJ (2016) Preparation and characterization of biodegradable nano hydroxyapatite\u2013bacterial cellulose composites with well-defined honeycomb pore arrays for bone tissue engineering applications. Cellulose 23:1263\u20131282. \nhttps:\/\/doi.org\/10.1007\/s10570-016-0867-4","journal-title":"Cellulose"},{"key":"4_CR35","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","volume":"6","author":"X Feng","year":"2011","unstructured":"Feng X, McDonald JM (2011) Disorders of bone remodeling. Ann Rev Pathol: Mech Dis 6:121\u2013145. \nhttps:\/\/doi.org\/10.1146\/annurev-pathol-011110-130203","journal-title":"Ann Rev Pathol: Mech Dis"},{"issue":"15-16","key":"4_CR36","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1089\/ten.tea.2016.0460","volume":"23","author":"S\u00f2nia Font Tellado","year":"2017","unstructured":"Font Tellado S, Bonani W, Balmayor ER, Foehr P, Motta A, Migliaresi C, van Griensven M (2017) Fabrication and characterization of biphasic silk fibroin scaffolds for tendon\/ligament-to-bone tissue engineering. Tissue Eng Part A 23(15\u201316):859\u2013872. \nhttps:\/\/doi.org\/10.1089\/ten.tea.2016.0460","journal-title":"Tissue Engineering Part A"},{"key":"4_CR37","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1039\/B402005G","volume":"14","author":"P Fratzl","year":"2004","unstructured":"Fratzl P, Gupta H, Paschalis E, Roschger P (2004) Structure and mechanical quality of the collagen\u2013mineral nano-composite in bone. J Mater Chem 14:2115\u20132123. \nhttps:\/\/doi.org\/10.1039\/B402005G","journal-title":"J Mater Chem"},{"key":"4_CR38","doi-asserted-by":"publisher","first-page":"9167","DOI":"10.1016\/j.biomaterials.2012.09.009","volume":"33","author":"ME Frohbergh","year":"2012","unstructured":"Frohbergh ME, Katsman A, Botta GP, Lazarovici P, Schauer CL, Wegst UG, Lelkes PI (2012) Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering. Biomaterials 33:9167\u20139178. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2012.09.009","journal-title":"Biomaterials"},{"key":"4_CR39","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1007\/s10853-013-7145-8","volume":"48","author":"Y-F Goh","year":"2013","unstructured":"Goh Y-F, Shakir I, Hussain R (2013) Electrospun fibers for tissue engineering, drug delivery, and wound dressing. J Mater Sci 48:3027\u20133054. \nhttps:\/\/doi.org\/10.1007\/s10853-013-7145-8","journal-title":"J Mater Sci"},{"key":"4_CR40","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1016\/j.biomaterials.2008.12.079","volume":"30","author":"D Gupta","year":"2009","unstructured":"Gupta D, Venugopal J, Mitra S, Dev VG, Ramakrishna S (2009) Nanostructured biocomposite substrates by electrospinning and electrospraying for the mineralization of osteoblasts. Biomaterials 30:2085\u20132094. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2008.12.079","journal-title":"Biomaterials"},{"key":"4_CR41","volume-title":"Basic orthopedic biomechanics","author":"WC Hayes","year":"1997","unstructured":"Hayes WC, Mow VC (1997) Basic orthopedic biomechanics. Lippincott-Raven, Philadelphia"},{"key":"4_CR42","unstructured":"Healy K, Guldberg R (2007) Bone tissue engineering. J Musculoskelet Neuronal Interact 7(4):328\u2013330\u00a0"},{"key":"4_CR43","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1080\/10611860903106034","volume":"17","author":"S Heuking","year":"2009","unstructured":"Heuking S, Adam-Malpel S, Sublet E, Iannitelli A, Ad S, Borchard G (2009) Stimulation of human macrophages (THP-1) using Toll-like receptor-2 (TLR-2) agonist decorated nanocarriers. J Drug Target 17:662\u2013670. \nhttps:\/\/doi.org\/10.1080\/10611860903106034","journal-title":"J Drug Target"},{"key":"4_CR44","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nm1716","volume":"14","author":"MJ Hilton","year":"2008","unstructured":"Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R (2008) Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 14:306\u2013314. \nhttps:\/\/doi.org\/10.1038\/nm1716","journal-title":"Nat Med"},{"key":"4_CR45","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/BF00705371","volume":"3","author":"R Hodgskinson","year":"1992","unstructured":"Hodgskinson R, Currey J (1992) Young's modulus, density and material properties in cancellous bone over a large density range. J Mater Sci Mater Med 3:377\u2013381. \nhttps:\/\/doi.org\/10.1007\/BF00705371","journal-title":"J Mater Sci Mater Med"},{"key":"4_CR46","doi-asserted-by":"publisher","first-page":"9622","DOI":"10.1016\/j.biomaterials.2011.09.009","volume":"32","author":"JM Holzwarth","year":"2011","unstructured":"Holzwarth JM, Ma PX (2011) Biomimetic nanofibrous scaffolds for bone tissue engineering. Biomaterials 32:9622\u20139629. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2011.09.009","journal-title":"Biomaterials"},{"key":"4_CR47","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1016\/j.biomaterials.2011.01.004","volume":"32","author":"A Hoppe","year":"2011","unstructured":"Hoppe A, G\u00fcldal NS, Boccaccini AR (2011) A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials 32:2757\u20132774. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2011.01.004","journal-title":"Biomaterials"},{"key":"4_CR48","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1089\/ten.teb.2009.0224","volume":"16","author":"EA Horner","year":"2010","unstructured":"Horner EA, Kirkham J, Wood D, Curran S, Smith M, Thomson B, Yang XB (2010) Long bone defect models for tissue engineering applications: criteria for choice. Tissue Eng Part B: Rev 16:263\u2013271. \nhttps:\/\/doi.org\/10.1089\/ten.teb.2009.0224","journal-title":"Tissue Eng Part B: Rev"},{"key":"4_CR49","first-page":"320","volume":"47","author":"M Huo","year":"2014","unstructured":"Huo M, Bian S, Hao J, Wang J (2014) Effects of chitosan on gene expression related to the canonical Wnt signaling pathway in the femur of fluorotic mice. Fluoride 47:320\u2013332","journal-title":"Fluoride"},{"issue":"24","key":"4_CR50","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","volume":"21","author":"Dietmar W. Hutmacher","year":"2000","unstructured":"Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529\u20132543. \nhttps:\/\/doi.org\/10.1016\/S0142-9612(00)00121-6","journal-title":"Biomaterials"},{"key":"4_CR51","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/term.24","volume":"1","author":"DW Hutmacher","year":"2007","unstructured":"Hutmacher DW, Schantz JT, Lam CXF, Tan KC, Lim TC (2007) State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. J Tissue Eng Regen Med 1:245\u2013260. \nhttps:\/\/doi.org\/10.1002\/term.24","journal-title":"J Tissue Eng Regen Med"},{"key":"4_CR52","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/mabi.201300058","volume":"13","author":"M Ignatova","year":"2013","unstructured":"Ignatova M, Manolova N, Rashkov I (2013) Electrospun antibacterial chitosan-based fibers. Macromol Biosci 13:860\u2013872. \nhttps:\/\/doi.org\/10.1002\/mabi.201300058","journal-title":"Macromol Biosci"},{"key":"4_CR53","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.addr.2009.07.008","volume":"61","author":"J-H Jang","year":"2009","unstructured":"Jang J-H, Castano O, Kim H-W (2009) Electrospun materials as potential platforms for bone tissue engineering. Adv Drug Deliv Rev 61:1065\u20131083. \nhttps:\/\/doi.org\/10.1016\/j.addr.2009.07.008","journal-title":"Adv Drug Deliv Rev"},{"key":"4_CR54","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.pmatsci.2010.03.001","volume":"55","author":"R Jayakumar","year":"2010","unstructured":"Jayakumar R, Prabaharan M, Nair S, Tokura S, Tamura H, Selvamurugan N (2010) Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications. Prog Mater Sci 55:675\u2013709. \nhttps:\/\/doi.org\/10.1016\/j.pmatsci.2010.03.001","journal-title":"Prog Mater Sci"},{"key":"4_CR55","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1021\/bm025581u","volume":"3","author":"H-J Jin","year":"2002","unstructured":"Jin H-J, Fridrikh SV, Rutledge GC, Kaplan DL (2002) Electrospinning Bombyx mori silk with poly (ethylene oxide). Biomacromolecules 3:1233\u20131239. \nhttps:\/\/doi.org\/10.1021\/bm025581u","journal-title":"Biomacromolecules"},{"key":"4_CR56","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/jbm.b.31392","volume":"91","author":"JH Jo","year":"2009","unstructured":"Jo JH, Lee EJ, Shin DS, Kim HE, Kim HW, Koh YH, Jang JH (2009) In vitro\/in vivo biocompatibility and mechanical properties of bioactive glass nanofiber and poly (\u03b5-caprolactone) composite materials. J Biomed Mater Res B: Appl Biomater 91:213\u2013220. \nhttps:\/\/doi.org\/10.1002\/jbm.b.31392","journal-title":"J Biomed Mater Res B: Appl Biomater"},{"key":"4_CR57","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00441-008-0610-z","volume":"332","author":"Y-J Ju","year":"2008","unstructured":"Ju Y-J, Muneta T, Yoshimura H, Koga H, Sekiya I (2008) Synovial mesenchymal stem cells accelerate early remodeling of tendon-bone healing. Cell Tissue Res 332:469\u2013478. \nhttps:\/\/doi.org\/10.1007\/s00441-008-0610-z","journal-title":"Cell Tissue Res"},{"key":"4_CR58","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.biomaterials.2009.10.059","volume":"31","author":"JM Kanczler","year":"2010","unstructured":"Kanczler JM, Ginty PJ, White L, Clarke NM, Howdle SM, Shakesheff KM, Oreffo RO (2010) The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials 31:1242\u20131250. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2009.10.059","journal-title":"Biomaterials"},{"key":"4_CR59","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1007\/s10439-004-7825-2","volume":"32","author":"TS Karande","year":"2004","unstructured":"Karande TS, Ong JL, Agrawal CM (2004) Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixing. Ann Biomed Eng 32:1728\u20131743. \nhttps:\/\/doi.org\/10.1007\/s10439-004-7825-2","journal-title":"Ann Biomed Eng"},{"key":"4_CR60","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/12_2011_131","volume-title":"Biomedical applications of polymeric nanofibers","author":"E Katsanevakis","year":"2011","unstructured":"Katsanevakis E, Wen X, Zhang N (2011) Creating electrospun nanofiber-based biomimetic scaffolds for bone regeneration. In: Biomedical applications of polymeric nanofibers. Springer, Heidelberg, pp 63\u2013100. \nhttps:\/\/doi.org\/10.1007\/12_2011_131"},{"key":"4_CR61","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/jbm.a.30976","volume":"81","author":"JD Kaufman","year":"2007","unstructured":"Kaufman JD, Song J, Klapperich CM (2007) Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res Part A 81:611\u2013623. \nhttps:\/\/doi.org\/10.1002\/jbm.a.30976","journal-title":"J Biomed Mater Res Part A"},{"key":"4_CR62","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1166\/jbn.2012.1363","volume":"8","author":"K Kavya","year":"2012","unstructured":"Kavya K, Dixit R, Jayakumar R, Nair SV, Chennazhi KP (2012) Synthesis and characterization of chitosan\/chondroitin sulfate\/nano-SiO2 composite scaffold for bone tissue engineering. J Biomed Nanotechnol 8:149\u2013160. \nhttps:\/\/doi.org\/10.1166\/jbn.2012.1363","journal-title":"J Biomed Nanotechnol"},{"key":"4_CR63","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1021\/acsami.6b14351","volume":"9","author":"DK Kim","year":"2017","unstructured":"Kim DK, Kim JI, Hwang TI, Sim BR, Khang G (2017) Bioengineered osteoinductive Broussonetia kazinoki\/Silk fibroin composite scaffolds for bone tissue regeneration. ACS Appl Mater Interfaces 9:1384\u20131394. \nhttps:\/\/doi.org\/10.1021\/acsami.6b14351","journal-title":"ACS Appl Mater Interfaces"},{"key":"4_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biotechadv.2007.07.009","volume":"26","author":"I-Y Kim","year":"2008","unstructured":"Kim I-Y, Seo S-J, Moon H-S, Yoo M-K, Park I-Y, Kim B-C, Cho C-S (2008) Chitosan and its derivatives for tissue engineering. Appl Biotechnol Adv 26:1\u201321. \nhttps:\/\/doi.org\/10.1016\/j.biotechadv.2007.07.009","journal-title":"Appl Biotechnol Adv"},{"issue":"9","key":"4_CR65","doi-asserted-by":"publisher","first-page":"7614","DOI":"10.1021\/acsami.7b03328","volume":"10","author":"Eunkyung Ko","year":"2017","unstructured":"Ko E, Lee JS, Kim H, Yang SY, Yang D, Yang K, Lee J, Shin J, Yang HS, Ryu W (2017) Electrospun silk fibroin Nanofibrous scaffolds with two-stage hydroxyapatite functionalization for enhancing the osteogenic differentiation of human adipose-derived mesenchymal stem cells. ACS Appl Mater Interfaces 10(9):7614\u20137625. \nhttps:\/\/doi.org\/10.1021\/acsami.7b03328","journal-title":"ACS Applied Materials & Interfaces"},{"key":"4_CR66","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1359\/jbmr.2001.16.6.1004","volume":"16","author":"T Kon","year":"2001","unstructured":"Kon T, Cho TJ, Aizawa T, Yamazaki M, Nooh N, Graves D, Gerstenfeld LC, Einhorn TA (2001) Expression of Osteoprotegerin, receptor activator of NF-\u03baB ligand (Osteoprotegerin ligand) and related Proinflammatory cytokines during fracture healing. J Bone Mineral Res 16:1004\u20131014. \nhttps:\/\/doi.org\/10.1359\/jbmr.2001.16.6.1004","journal-title":"J Bone Mineral Res"},{"key":"4_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s11671-016-1532-4","volume":"11","author":"S Kwak","year":"2016","unstructured":"Kwak S, Haider A, Gupta KC, Kim S, Kang I-K (2016) Micro\/nano multilayered scaffolds of PLGA and collagen by alternately electrospinning for bone tissue engineering. Nanoscale Res Lett 11:1\u201316. \nhttps:\/\/doi.org\/10.1186\/s11671-016-1532-4","journal-title":"Nanoscale Res Lett"},{"key":"4_CR68","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s40824-017-0097-3","volume":"21","author":"G-W Kwon","year":"2017","unstructured":"Kwon G-W, Gupta KC, Jung K-H, Kang I-K (2017) Lamination of microfibrous PLGA fabric by electrospinning a layer of collagen-hydroxyapatite composite nanofibers for bone tissue engineering. Biomater Res 21:11. \nhttps:\/\/doi.org\/10.1186\/s40824-017-0097-3","journal-title":"Biomater Res"},{"key":"4_CR69","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.carbpol.2014.04.094","volume":"111","author":"G-J Lai","year":"2014","unstructured":"Lai G-J, Shalumon K, Chen S-H, Chen J-P (2014) Composite chitosan\/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydr polym 111:288\u2013297. \nhttps:\/\/doi.org\/10.1016\/j.carbpol.2014.04.094","journal-title":"Carbohydr polym"},{"key":"4_CR70","doi-asserted-by":"publisher","first-page":"4437","DOI":"10.1016\/S0142-9612(02)00139-4","volume":"23","author":"R Landers","year":"2002","unstructured":"Landers R, H\u00fcbner U, Schmelzeisen R, M\u00fclhaupt R (2002) Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 23:4437\u20134447. \nhttps:\/\/doi.org\/10.1016\/S0142-9612(02)00139-4","journal-title":"Biomaterials"},{"key":"4_CR71","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1039\/C4TB00027G","volume":"2","author":"SKL Levengood","year":"2014","unstructured":"Levengood SKL, Zhang M (2014) Chitosan-based scaffolds for bone tissue engineering. J Mater Chem B 2:3161\u20133184. \nhttps:\/\/doi.org\/10.1039\/C4TB00027G","journal-title":"J Mater Chem B"},{"key":"4_CR72","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1016\/j.biomaterials.2006.01.022","volume":"27","author":"C Li","year":"2006","unstructured":"Li C, Vepari C, Jin H-J, Kim HJ, Kaplan DL (2006) Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27:3115\u20133124. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2006.01.022","journal-title":"Biomaterials"},{"key":"4_CR73","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1021\/nl0344256","volume":"3","author":"D Li","year":"2003","unstructured":"Li D, Wang Y, Xia Y (2003) Electrospinning of polymeric and ceramic nanofibers as uniaxially aligned arrays. Nano Lett 3:1167\u20131171. \nhttps:\/\/doi.org\/10.1021\/nl0344256","journal-title":"Nano Lett"},{"key":"4_CR74","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1002\/jbm.a.34539","volume":"101","author":"X Li","year":"2013","unstructured":"Li X, Wang L, Fan Y, Feng Q, Cui FZ, Watari F (2013) Nanostructured scaffolds for bone tissue engineering. J Biomed Mater Res Part A 101:2424\u20132435. \nhttps:\/\/doi.org\/10.1002\/jbm.a.34539","journal-title":"J Biomed Mater Res Part A"},{"key":"4_CR75","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1002\/jbm.a.34801","volume":"102","author":"X Li","year":"2014","unstructured":"Li X, Yang Y, Fan Y, Feng Q, Cui FZ, Watari F (2014) Biocomposites reinforced by fibers or tubes as scaffolds for tissue engineering or regenerative medicine. J Biomed Mater Res Part A 102:1580\u20131594. \nhttps:\/\/doi.org\/10.1002\/jbm.a.34801","journal-title":"J Biomed Mater Res Part A"},{"key":"4_CR76","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/jbm.10183","volume":"63","author":"HR Lin","year":"2002","unstructured":"Lin HR, Kuo CJ, Yang C-Y, Shaw SY, Wu YJ (2002) Preparation of macroporous biodegradable PLGA scaffolds for cell attachment with the use of mixed salts as porogen additives. J Biomed Mater Res 63:271\u2013279. \nhttps:\/\/doi.org\/10.1002\/jbm.10183","journal-title":"J Biomed Mater Res"},{"key":"4_CR77","doi-asserted-by":"publisher","first-page":"5315","DOI":"10.1039\/C4NR00355A","volume":"6","author":"H Liu","year":"2014","unstructured":"Liu H, Cheng J, Chen F, Bai D, Shao C, Wang J, Xi P, Zeng Z (2014a) Gelatin functionalized graphene oxide for mineralization of hydroxyapatite: biomimetic and in vitro evaluation. Nanoscale 6:5315\u20135322. \nhttps:\/\/doi.org\/10.1039\/C4NR00355A","journal-title":"Nanoscale"},{"key":"4_CR78","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.1021\/jp2102226","volume":"116","author":"H Liu","year":"2012","unstructured":"Liu H, Xi P, Xie G, Shi Y, Hou F, Huang L, Chen F, Zeng Z, Shao C, Wang J (2012) Simultaneous reduction and surface functionalization of graphene oxide for hydroxyapatite mineralization. J Phys Chem C 116:3334\u20133341. \nhttps:\/\/doi.org\/10.1021\/jp2102226","journal-title":"J Phys Chem C"},{"key":"4_CR79","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1021\/jp2102226","volume":"435","author":"L Liu","year":"2006","unstructured":"Liu L, Huang Z-M, He C, Han X (2006) Mechanical performance of laminated composites incorporated with nanofibrous membranes. Mater Sci Eng: A 435:309\u2013317. \nhttps:\/\/doi.org\/10.1021\/jp2102226","journal-title":"Mater Sci Eng: A"},{"key":"4_CR80","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1016\/j.actbio.2014.08.036","volume":"10","author":"Y Liu","year":"2014","unstructured":"Liu Y, Cui H, Zhuang X, Wei Y, Chen X (2014b) Electrospinning of aniline pentamer-graft-gelatin\/PLLA nanofibers for bone tissue engineering. Acta Biomater 10:5074\u20135080. \nhttps:\/\/doi.org\/10.1016\/j.actbio.2014.08.036","journal-title":"Acta Biomater"},{"key":"4_CR81","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1007\/s10439-015-1516-z","volume":"44","author":"G Lotfi","year":"2016","unstructured":"Lotfi G, Shokrgozar MA, Mofid R, Abbas FM, Ghanavati F, Baghban AA, Yavari SK, Pajoumshariati S (2016) Biological evaluation (in vitro and in vivo) of Bilayered collagenous coated (Nano electrospun and Solid Wall) chitosan membrane for periodontal guided bone regeneration. Ann Biomed Eng 44:2132\u20132144. \nhttps:\/\/doi.org\/10.1007\/s10439-015-1516-z","journal-title":"Ann Biomed Eng"},{"key":"4_CR82","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.biomaterials.2011.09.039","volume":"33","author":"B Marelli","year":"2012","unstructured":"Marelli B, Ghezzi CE, Alessandrino A, Barralet JE, Freddi G, Nazhat SN (2012) Silk fibroin derived polypeptide-induced biomineralization of collagen. Biomaterials 33:102\u2013108. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2011.09.039","journal-title":"Biomaterials"},{"issue":"6","key":"4_CR83","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2217\/17435889.2.6.929","volume":"2","author":"A Martins","year":"2007","unstructured":"Martins A, Ara\u00fajo JV, Reis RL, Neves NM (2007) Electrospun nanostructured scaffolds for tissue engineering applications. Nanomedicine 2(6):929\u2013942. \nhttps:\/\/doi.org\/10.2217\/17435889.2.6.929","journal-title":"Nanomedicine"},{"key":"4_CR84","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1002\/app.38091","volume":"128","author":"M Mehraban","year":"2013","unstructured":"Mehraban M, Zadhoush A, Abdolkarim Hosseini Ravandi S, Bagheri R, Heidarkhan Tehrani A (2013) Preparation of porous nanofibers from electrospun polyacrylonitrile\/calcium carbonate composite nanofibers using porogen leaching technique. J Appl Polym Sci 128:926\u2013933. \nhttps:\/\/doi.org\/10.1002\/app.38091","journal-title":"J Appl Polym Sci"},{"key":"4_CR85","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/0022034508327868","volume":"88","author":"L Meng","year":"2009","unstructured":"Meng L, Bian Z, Torensma R, Von den Hoff J (2009) Biological mechanisms in palatogenesis and cleft palate. J Dent Res 88:22\u201333. \nhttps:\/\/doi.org\/10.1177\/0022034508327868","journal-title":"J Dent Res"},{"key":"4_CR86","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1006\/bbrc.1995.1368","volume":"208","author":"N Minoura","year":"1995","unstructured":"Minoura N, Aiba S-I, Higuchi M, Gotoh Y, Tsukada M, Imai Y (1995) Attachment and growth of fibroblast cells on silk fibroin. Biochem Biophys Res Commun 208:511\u2013516. \nhttps:\/\/doi.org\/10.1006\/bbrc.1995.1368","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"4_CR87","doi-asserted-by":"publisher","first-page":"241","DOI":"10.4103\/0972-124X.99269","volume":"16","author":"Surajit Mistry","year":"2012","unstructured":"Mistry S, Kundu D, Datta S, Basu D (2012) Effects of bioactive glass, hydroxyapatite and bioactive glass\u2013hydroxyapatite composite graft particles in the treatment of infrabony defects. J Indian Soc Periodontol 16(2):241\u2013246. \nhttps:\/\/doi.org\/10.4103\/0972-124X.99269","journal-title":"Journal of Indian Society of Periodontology"},{"issue":"39","key":"4_CR88","doi-asserted-by":"publisher","first-page":"33695","DOI":"10.1021\/acsami.7b13199","volume":"9","author":"Sakthivel Nagarajan","year":"2017","unstructured":"Nagarajan S, Belaid H, Pochat-Bohatier C, Teyssier C, Iatsunskyi I, Coy E, Balme S, Cornu D, Miele P, Kalkura NS (2017) Design of boron nitride\/gelatin electrospun nanofibers for bone tissue engineering ACS Appl Mater Interfaces 9:33695\u201333706. doi: \nhttps:\/\/doi.org\/10.1021\/acsami.7b13199","journal-title":"ACS Applied Materials & Interfaces"},{"key":"4_CR89","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.biomaterials.2017.05.014","volume":"136","author":"D Naskar","year":"2017","unstructured":"Naskar D, Ghosh AK, Mandal M, Das P, Nandi SK, Kundu SC (2017) Dual growth factor loaded nonmulberry silk fibroin\/carbon nanofiber composite 3D scaffolds for in vitro and in vivo bone regeneration. Biomaterials 136:67\u201385. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2017.05.014","journal-title":"Biomaterials"},{"key":"4_CR90","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.carbpol.2015.11.055","volume":"138","author":"J Nourmohammadi","year":"2016","unstructured":"Nourmohammadi J, Ghaee A, Liavali SH (2016) Preparation and characterization of bioactive composite scaffolds from polycaprolactone nanofibers-chitosan-oxidized starch for bone regeneration. Carbohydr Polym 138:172\u2013179. \nhttps:\/\/doi.org\/10.1016\/j.carbpol.2015.11.055","journal-title":"Carbohydr Polym"},{"key":"4_CR91","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/j.addr.2010.03.009","volume":"62","author":"K Numata","year":"2010","unstructured":"Numata K, Kaplan DL (2010) Silk-based delivery systems of bioactive molecules. Adv Drug Deliv Rev 62:1497\u20131508. \nhttps:\/\/doi.org\/10.1016\/j.addr.2010.03.009","journal-title":"Adv Drug Deliv Rev"},{"key":"4_CR92","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.carbpol.2016.02.053","volume":"144","author":"A Pangon","year":"2016","unstructured":"Pangon A, Saesoo S, Saengkrit N, Ruktanonchai U, Intasanta V (2016) Hydroxyapatite-hybridized chitosan\/chitin whisker bionanocomposite fibers for bone tissue engineering applications. Carbohydr Polym 144:419\u2013427. \nhttps:\/\/doi.org\/10.1016\/j.carbpol.2016.02.053","journal-title":"Carbohydr Polym"},{"key":"4_CR93","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.1016\/j.biomaterials.2010.04.028","volume":"31","author":"S-H Park","year":"2010","unstructured":"Park S-H, Gil ES, Shi H, Kim HJ, Lee K, Kaplan DL (2010) Relationships between degradability of silk scaffolds and osteogenesis. Biomaterials 31:6162\u20136172. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2010.04.028","journal-title":"Biomaterials"},{"key":"4_CR94","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1016\/j.biomaterials.2011.12.036","volume":"33","author":"C Patra","year":"2012","unstructured":"Patra C, Talukdar S, Novoyatleva T, Velagala SR, M\u00fchlfeld C, Kundu B, Kundu SC, Engel FB (2012) Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering. Biomaterials 33:2673\u20132680. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2011.12.036","journal-title":"Biomaterials"},{"key":"4_CR95","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-642-57276-0_1","volume-title":"Current Topics in Microbiology and Immunology","author":"M. F. Pittenger","year":"2000","unstructured":"Pittenger M, Mosca J, McIntosh K (2000) Human mesenchymal stem cells: progenitor cells for cartilage, bone, fat and stroma Lymphoid organogenesis:3\u201311. doi: \nhttps:\/\/doi.org\/10.1007\/978-3-642-57276-0_1"},{"key":"4_CR96","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1115\/1.429659","volume":"122","author":"B Porter","year":"2000","unstructured":"Porter B, Oldham J, He S, Zobitz M, Payne R, An K-N, Currier B, Mikos A, Yaszemski MJ (2000) Mechanical properties of a biodegradable bone regeneration scaffold. J Biomech Eng 122:286\u2013288. \nhttps:\/\/doi.org\/10.1115\/1.429659","journal-title":"J Biomech Eng"},{"key":"4_CR97","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/btpr.246","volume":"25","author":"JR Porter","year":"2009","unstructured":"Porter JR, Ruckh TT, Popat KC (2009) Bone tissue engineering: a review in bone biomimetics and drug delivery strategies. Biotechnol Prog 25:1539\u20131560. \nhttps:\/\/doi.org\/10.1002\/btpr.246","journal-title":"Biotechnol Prog"},{"key":"4_CR98","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1016\/j.actbio.2009.05.007","volume":"5","author":"MP Prabhakaran","year":"2009","unstructured":"Prabhakaran MP, Venugopal J, Ramakrishna S (2009) Electrospun nanostructured scaffolds for bone tissue engineering. Acta Biomaterialia 5:2884\u20132893. \nhttps:\/\/doi.org\/10.1016\/j.actbio.2009.05.007","journal-title":"Acta Biomaterialia"},{"key":"4_CR99","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s11914-013-0145-4","volume":"11","author":"J Regan","year":"2013","unstructured":"Regan J, Long F (2013) Notch signaling and bone remodeling. Curr Osteoporos Rep 11:126\u2013129. \nhttps:\/\/doi.org\/10.1007\/s11914-013-0145-4","journal-title":"Curr Osteoporos Rep"},{"key":"4_CR100","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s10856-007-3181-8","volume":"19","author":"J Ren","year":"2008","unstructured":"Ren J, Zhao P, Ren T, Gu S, Pan K (2008) Poly (D, L-lactide)\/nano-hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation. J Mater Sci Mater Med 19:1075\u20131082. \nhttps:\/\/doi.org\/10.1007\/s10856-007-3181-8","journal-title":"J Mater Sci Mater Med"},{"key":"4_CR101","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.msec.2017.04.084","volume":"78","author":"K Ren","year":"2017","unstructured":"Ren K, Wang Y, Sun T, Yue W, Zhang H (2017a) Electrospun PCL\/gelatin composite nanofiber structures for effective guided bone regeneration membranes. Mater Sci Eng: C 78:324\u2013332. \nhttps:\/\/doi.org\/10.1016\/j.msec.2017.04.084","journal-title":"Mater Sci Eng: C"},{"key":"4_CR102","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.biomaterials.2015.01.059","volume":"50","author":"X Ren","year":"2015","unstructured":"Ren X, Bischoff D, Weisgerber DW, Lewis MS, Tu V, Yamaguchi DT, Miller TA, Harley BA, Lee JC (2015) Osteogenesis on nanoparticulate mineralized collagen scaffolds via autogenous activation of the canonical BMP receptor signaling pathway. Biomaterials 50:107\u2013114. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2015.01.059","journal-title":"Biomaterials"},{"key":"4_CR103","doi-asserted-by":"publisher","first-page":"025036","DOI":"10.1088\/1758-5090\/aa747f","volume":"9","author":"Z Ren","year":"2017","unstructured":"Ren Z, Ma S, Jin L, Liu Z, Liu D, Zhang X, Cai Q, Yang X (2017b) Repairing a bone defect with a three-dimensional cellular construct composed of a multi-layered cell sheet on electrospun mesh. Biofabrication 9:025036. \nhttps:\/\/doi.org\/10.1088\/1758-5090\/aa747f","journal-title":"Biofabrication"},{"key":"4_CR104","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1016\/j.polymer.2008.02.002","volume":"49","author":"DH Reneker","year":"2008","unstructured":"Reneker DH, Yarin AL (2008) Electrospinning jets and polymer nanofibers. Polymer 49:2387\u20132425. \nhttps:\/\/doi.org\/10.1016\/j.polymer.2008.02.002","journal-title":"Polymer"},{"key":"4_CR105","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1016\/j.actbio.2014.05.024","volume":"10","author":"N Reznikov","year":"2014","unstructured":"Reznikov N, Shahar R, Weiner S (2014) Bone hierarchical structure in three dimensions. Acta biomaterialia 10:3815\u20133826. \nhttps:\/\/doi.org\/10.1016\/j.actbio.2014.05.024","journal-title":"Acta biomaterialia"},{"key":"4_CR106","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S1350-4533(98)00007-1","volume":"20","author":"J-Y Rho","year":"1998","unstructured":"Rho J-Y, Kuhn-Spearing L, Zioupos P (1998) Mechanical properties and the hierarchical structure of bone. Med Eng Phys 20:92\u2013102. \nhttps:\/\/doi.org\/10.1016\/S1350-4533(98)00007-1","journal-title":"Med Eng Phys"},{"key":"4_CR107","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/1616-3028(20020101)12:1<33::AID-ADFM33>3.0.CO;2-E","volume":"12","author":"TJ Rivers","year":"2002","unstructured":"Rivers TJ, Hudson TW, Schmidt CE (2002) Synthesis of a novel, biodegradable electrically conducting polymer for biomedical applications. Adv Funct Mater 12:33\u201337. https:\/\/doi.org\/10.1002\/1616-3028(20020101)12:1<33::AID-ADFM33>3.0.CO;2-E","journal-title":"Adv Funct Mater"},{"key":"4_CR108","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.carbpol.2012.12.037","volume":"100","author":"K Rodr\u00edguez","year":"2014","unstructured":"Rodr\u00edguez K, Sundberg J, Gatenholm P, Renneckar S (2014) Electrospun nanofibrous cellulose scaffolds with controlled microarchitecture. Carbohydr Polym 100:143\u2013149. \nhttps:\/\/doi.org\/10.1016\/j.carbpol.2012.12.037","journal-title":"Carbohydr Polym"},{"key":"4_CR109","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/jbm.a.35965","volume":"105","author":"R Romero","year":"2017","unstructured":"Romero R, Travers JK, Asbury E, Pennybaker A, Chubb L, Rose R, Ehrhart NP, Kipper MJ (2017) Combined delivery of FGF-2, TGF-\u03b21, and adipose-derived stem cells from an engineered periosteum to a critical-sized mouse femur defect. J Biomed Mater Res Part A 105:900\u2013911. \nhttps:\/\/doi.org\/10.1002\/jbm.a.35965","journal-title":"J Biomed Mater Res Part A"},{"key":"4_CR110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00264-017-3522-2","volume":"41","author":"S-Q Ruan","year":"2017","unstructured":"Ruan S-Q, Yan L, Deng J, Huang W-L, Jiang D-M (2017) Preparation of a biphase composite scaffold and its application in tissue engineering for femoral osteochondral defects in rabbits. International Orthopaedics 41:1\u201310. \nhttps:\/\/doi.org\/10.1007\/s00264-017-3522-2","journal-title":"International Orthopaedics"},{"key":"4_CR111","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S8756-3282(03)00194-7","volume":"33","author":"MA Rubin","year":"2003","unstructured":"Rubin MA, Jasiuk I, Taylor J, Rubin J, Ganey T, Apkarian RP (2003) TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone 33:270\u2013282. \nhttps:\/\/doi.org\/10.1016\/S8756-3282(03)00194-7","journal-title":"Bone"},{"key":"4_CR112","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1089\/ten.2006.12.2479","volume":"12","author":"E Sachlos","year":"2006","unstructured":"Sachlos E, Gotora D, Czernuszka JT (2006) Collagen scaffolds reinforced with biomimetic composite nano-sized carbonate-substituted hydroxyapatite crystals and shaped by rapid prototyping to contain internal microchannels. Tissue Eng 12:2479\u20132487. \nhttps:\/\/doi.org\/10.1089\/ten.2006.12.2479","journal-title":"Tissue Eng"},{"key":"4_CR113","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/jbm.a.35954","volume":"105","author":"A Salifu","year":"2017","unstructured":"Salifu A, Lekakou C, Labeed F (2017) Multilayer cellular stacks of gelatin-hydroxyapatite fiber scaffolds for bone tissue engineering. J Biomed Mater Res Part A 105:779\u2013789. \nhttps:\/\/doi.org\/10.1002\/jbm.a.35954","journal-title":"J Biomed Mater Res Part A"},{"key":"4_CR114","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.ijbiomac.2016.01.112","volume":"93","author":"S Saravanan","year":"2016","unstructured":"Saravanan S, Leena R, Selvamurugan N (2016) Chitosan based biocomposite scaffolds for bone tissue engineering. Int J Biol Macromol 93:1354\u20131365. \nhttps:\/\/doi.org\/10.1016\/j.ijbiomac.2016.01.112","journal-title":"Int J Biol Macromol"},{"key":"4_CR115","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3390\/polym2040522","volume":"2","author":"SA Sell","year":"2010","unstructured":"Sell SA, Wolfe PS, Garg K, McCool JM, Rodriguez IA, Bowlin GL (2010) The use of natural polymers in tissue engineering: a focus on electrospun extracellular matrix analogues. Polymers 2:522\u2013553. \nhttps:\/\/doi.org\/10.3390\/polym2040522","journal-title":"Polymers"},{"key":"4_CR116","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1023\/B:BILE.0000032962.79531.fd","volume":"26","author":"Y-J Seol","year":"2004","unstructured":"Seol Y-J, Lee J-Y, Park Y-J, Lee Y-M, Rhyu I-C, Lee S-J, Han S-B, Chung C-P (2004) Chitosan sponges as tissue engineering scaffolds for bone formation. Biotechnol Lett 26:1037\u20131041. \nhttps:\/\/doi.org\/10.1023\/B:BILE.0000032962.79531.fd","journal-title":"Biotechnol Lett"},{"issue":"1-2","key":"4_CR117","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ijpharm.2017.03.088","volume":"524","author":"Hasham Shafi","year":"2017","unstructured":"Shafi H, Reddy DS, Khan T, Ranjan R, Srivastava A, Vaishya S, Sharma T, Siddiqui MI, Habib S, Misra A (2017) Dehydroascorbate-derivatized chitosan particles for targeting antimalarial agents to infected erythrocytes Int J Pharm 524 :205-214. doi: \nhttps:\/\/doi.org\/10.1016\/j.ijpharm.2017.03.088","journal-title":"International Journal of Pharmaceutics"},{"key":"4_CR118","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.msec.2016.05.081","volume":"67","author":"W Shao","year":"2016","unstructured":"Shao W, He J, Han Q, Sang F, Wang Q, Chen L, Cui S, Ding B (2016a) A biomimetic multilayer nanofiber fabric fabricated by electrospinning and textile technology from polylactic acid and Tussah silk fibroin as a scaffold for bone tissue engineering. Mater Sci Eng: C 67:599\u2013610. \nhttps:\/\/doi.org\/10.1016\/j.msec.2016.05.081","journal-title":"Mater Sci Eng: C"},{"key":"4_CR119","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.msec.2015.08.046","volume":"58","author":"W Shao","year":"2016","unstructured":"Shao W, He J, Sang F, Ding B, Chen L, Cui S, Li K, Han Q, Tan W (2016b) Coaxial electrospun aligned tussah silk fibroin nanostructured fiber scaffolds embedded with hydroxyapatite\u2013tussah silk fibroin nanoparticles for bone tissue engineering. Mater Sci Eng: C 58:342\u2013351. \nhttps:\/\/doi.org\/10.1016\/j.msec.2015.08.046","journal-title":"Mater Sci Eng: C"},{"key":"4_CR120","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.msec.2015.09.037","volume":"59","author":"E Sharifi","year":"2016","unstructured":"Sharifi E, Azami M, Kajbafzadeh A-M, Moztarzadeh F, Faridi-Majidi R, Shamousi A, Karimi R, Ai J (2016) Preparation of a biomimetic composite scaffold from gelatin\/collagen and bioactive glass fibers for bone tissue engineering. Mater Sci Eng: C 59:533\u2013541. \nhttps:\/\/doi.org\/10.1016\/j.msec.2015.09.037","journal-title":"Mater Sci Eng: C"},{"key":"4_CR121","doi-asserted-by":"publisher","unstructured":"Sheikh F, Kanjwal MA, Macossay J, Barakat N, Kim H (2012) A simple approach for synthesis, characterization and bioactivity of bovine bones to fabricate the polyurethane nanofiber containing hydroxyapatite nanoparticles. Express Polym Lett 6:41\u201353. \nhttps:\/\/doi.org\/10.3144\/expresspolymlett.2012.5,6","DOI":"10.3144\/expresspolymlett.2012.5,6"},{"key":"4_CR122","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1007\/BF03218929","volume":"17","author":"FA Sheikh","year":"2009","unstructured":"Sheikh FA, Barakat NA, Kanjwal MA, Chaudhari AA, Jung I-H, Lee JH, Kim HY (2009) Electrospun antimicrobial polyurethane nanofibers containing silver nanoparticles for biotechnological applications. Macromol Res 17:688\u2013696. \nhttps:\/\/doi.org\/10.1007\/BF03218929","journal-title":"Macromol Res"},{"key":"4_CR123","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/term.1989","volume":"10","author":"FA Sheikh","year":"2016","unstructured":"Sheikh FA, Ju HW, Moon BM, Lee OJ, Kim JH, Park HJ, Kim DW, Kim DK, Jang JE, Khang G (2016) Hybrid scaffolds based on PLGA and silk for bone tissue engineering. J Tissue Eng Regen Med 10:209\u2013221. \nhttps:\/\/doi.org\/10.1002\/term.1989","journal-title":"J Tissue Eng Regen Med"},{"key":"4_CR124","doi-asserted-by":"publisher","first-page":"5744","DOI":"10.3390\/ma8095273","volume":"8","author":"Z Sheikh","year":"2015","unstructured":"Sheikh Z, Najeeb S, Khurshid Z, Verma V, Rashid H, Glogauer M (2015) Biodegradable materials for bone repair and tissue engineering applications. Materials 8:5744\u20135794. \nhttps:\/\/doi.org\/10.3390\/ma8095273","journal-title":"Materials"},{"key":"4_CR125","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.biomaterials.2008.01.011","volume":"29","author":"TJ Sill","year":"2008","unstructured":"Sill TJ, von Recum HA (2008) Electrospinning: applications in drug delivery and tissue engineering. Biomaterials 29:1989\u20132006. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2008.01.011","journal-title":"Biomaterials"},{"key":"4_CR126","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.carbpol.2016.05.088","volume":"151","author":"B.N. Singh","year":"2016","unstructured":"Singh B, Panda N, Mund R, Pramanik K (2016) Carboxymethyl cellulose enables silk fibroin nanofibrous scaffold with enhanced biomimetic potential for bone tissue engineering application Carbohydr polym 151:335\u2013347. doi: \nhttps:\/\/doi.org\/10.1016\/j.carbpol.2016.05.088","journal-title":"Carbohydrate Polymers"},{"key":"4_CR127","doi-asserted-by":"publisher","first-page":"015028","DOI":"10.1088\/1758-5090\/aa644f","volume":"9","author":"B Singh","year":"2017","unstructured":"Singh B, Pramanik K (2017) Development of novel silk fibroin\/polyvinyl alcohol\/sol\u2013gel bioactive glass composite matrix by modified layer by layer electrospinning method for bone tissue construct generation. Biofabrication 9:015028. \nhttps:\/\/doi.org\/10.1088\/1758-5090\/aa644f","journal-title":"Biofabrication"},{"key":"4_CR128","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1007\/s11999-013-2988-5","volume":"471","author":"JK Smith","year":"2013","unstructured":"Smith JK, Moshref AR, Jennings JA, Courtney HS, Haggard WO (2013) Chitosan sponges for local synergistic infection therapy: a pilot study. Clin Orthop Relat Res\u00ae 471:3158\u20133164. \nhttps:\/\/doi.org\/10.1007\/s11999-013-2988-5","journal-title":"Clin Orthop Relat Res\u00ae"},{"key":"4_CR129","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/1097-4636(200101)54:1<139::AID-JBM17>3.0.CO;2-7","volume":"54","author":"S Sofia","year":"2001","unstructured":"Sofia S, McCarthy MB, Gronowicz G, Kaplan DL (2001) Functionalized silk-based biomaterials for bone formation. J Biomed Mater Res Part A 54:139\u2013148. https:\/\/doi.org\/10.1002\/1097-4636(200101)54:1<139::AID-JBM17>3.0.CO;2-7","journal-title":"J Biomed Mater Res Part A"},{"key":"4_CR130","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.phymed.2003.09.005","volume":"11","author":"H-Y Sohn","year":"2004","unstructured":"Sohn H-Y, Son K, Kwon C-S, Kwon G-S, Kang S (2004) Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine 11:666\u2013672. \nhttps:\/\/doi.org\/10.1016\/j.phymed.2003.09.005","journal-title":"Phytomedicine"},{"key":"4_CR131","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/jbm.b.30790","volume":"83","author":"JH Song","year":"2007","unstructured":"Song JH, Kim HE, Kim HW (2007) Collagen-apatite nanocomposite membranes for guided bone regeneration. J Biomed Mater Res B Appl Biomater 83:248\u2013257. \nhttps:\/\/doi.org\/10.1002\/jbm.b.30790","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"4_CR132","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.colsurfb.2013.04.006","volume":"109","author":"J Sowjanya","year":"2013","unstructured":"Sowjanya J, Singh J, Mohita T, Sarvanan S, Moorthi A, Srinivasan N, Selvamurugan N (2013) Biocomposite scaffolds containing chitosan\/alginate\/nano-silica for bone tissue engineering. Colloids Surf B: Biointerfaces 109:294\u2013300. \nhttps:\/\/doi.org\/10.1016\/j.colsurfb.2013.04.006","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"4_CR133","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1126\/science.1106587","volume":"310","author":"MM Stevens","year":"2005","unstructured":"Stevens MM, George JH (2005) Exploring and engineering the cell surface interface. Science 310:1135\u20131138. \nhttps:\/\/doi.org\/10.1126\/science.1106587","journal-title":"Science"},{"key":"4_CR134","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bone.2008.09.017","volume":"44","author":"A Teti","year":"2009","unstructured":"Teti A, Zallone A (2009) Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited. Bone 44:11\u201316. \nhttps:\/\/doi.org\/10.1016\/j.bone.2008.09.017","journal-title":"Bone"},{"key":"4_CR135","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.msec.2017.06.016","volume":"80","author":"S T\u00fcrkkan","year":"2017","unstructured":"T\u00fcrkkan S, Pazar\u00e7eviren AE, Keskin D, Machin NE, Duygulu \u00d6, Tezcaner A (2017) Nanosized CaP-silk fibroin-PCL-PEG-PCL\/PCL based bilayer membranes for guided bone regeneration. Mater Sci Eng C 80:484\u2013493. \nhttps:\/\/doi.org\/10.1016\/j.msec.2017.06.016","journal-title":"Mater Sci Eng C"},{"key":"4_CR136","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00198-005-2035-9","volume":"17","author":"S Viguet-Carrin","year":"2006","unstructured":"Viguet-Carrin S, Garnero P, Delmas P (2006) The role of collagen in bone strength. Osteoporos Int 17:319\u2013336. \nhttps:\/\/doi.org\/10.1007\/s00198-005-2035-9","journal-title":"Osteoporos Int"},{"key":"4_CR137","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.addr.2012.01.016","volume":"64","author":"TN Vo","year":"2012","unstructured":"Vo TN, Kasper FK, Mikos AG (2012) Strategies for controlled delivery of growth factors and cells for bone regeneration. Adv Drug Deliv Rev 64:1292\u20131309. \nhttps:\/\/doi.org\/10.1016\/j.addr.2012.01.016","journal-title":"Adv Drug Deliv Rev"},{"key":"4_CR138","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1002\/jbm.a.34823","volume":"102","author":"G Vozzi","year":"2014","unstructured":"Vozzi G, Corallo C, Carta S, Fortina M, Gattazzo F, Galletti M, Giordano N (2014) Collagen-gelatin-genipin-hydroxyapatite composite scaffolds colonized by human primary osteoblasts are suitable for bone tissue engineering applications: in vitro evidences. J Biomed Mater Res A 102:1415\u20131421. \nhttps:\/\/doi.org\/10.1002\/jbm.a.34823","journal-title":"J Biomed Mater Res A"},{"key":"4_CR139","doi-asserted-by":"publisher","unstructured":"Wan W, Zhang S, Ge L, Li Q, Fang X, Yuan Q, Zhong W, Ouyang J, Xing M (2015) Layer-by-layer paper-stacking nanofibrous membranes to deliver adipose-derived stem cells for bone regeneration. Int J Nanomedicine 10:1273\u20131290. \nhttps:\/\/doi.org\/10.2147\/IJN.S77118","DOI":"10.2147\/IJN.S77118"},{"key":"4_CR140","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1365-2184.2012.00806.x","volume":"45","author":"J Wang","year":"2012","unstructured":"Wang J, Liu B, Gu S, Liang J (2012) Effects of Wnt\/\u03b2-catenin signalling on proliferation and differentiation of apical papilla stem cells. Cell Prolif 45:121\u2013131. \nhttps:\/\/doi.org\/10.1111\/j.1365-2184.2012.00806.x","journal-title":"Cell Prolif"},{"key":"4_CR141","doi-asserted-by":"publisher","first-page":"025003","DOI":"10.1088\/1748-6041\/4\/2\/025003","volume":"4","author":"L Wang","year":"2009","unstructured":"Wang L, Li Y, Zuo Y, Zhang L, Zou Q, Cheng L, Jiang H (2009) Porous bioactive scaffold of aliphatic polyurethane and hydroxyapatite for tissue regeneration. Biomed Mater 4:025003. \nhttps:\/\/doi.org\/10.1088\/1748-6041\/4\/2\/025003","journal-title":"Biomed Mater"},{"key":"4_CR142","doi-asserted-by":"publisher","first-page":"89","DOI":"10.13005\/msri\/140202","volume":"14","author":"S Wani","year":"2017","unstructured":"Wani S, Sofi HS, Majeed S, Sheikh FA (2017) Recent trends in chitosan nanofibers: from tissue-engineering to environmental importance: a review. Mater Sci Res India 14:89\u201399. \nhttps:\/\/doi.org\/10.13005\/msri\/140202","journal-title":"Mater Sci Res India"},{"key":"4_CR143","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1006\/jsbi.1999.4107","volume":"126","author":"S Weiner","year":"1999","unstructured":"Weiner S, Traub W, Wagner HD (1999) Lamellar bone: structure\u2013function relations. J Struct Biol 126:241\u2013255. \nhttps:\/\/doi.org\/10.1006\/jsbi.1999.4107","journal-title":"J Struct Biol"},{"key":"4_CR144","doi-asserted-by":"publisher","first-page":"015004","DOI":"10.1088\/1748-605X\/aa853c","volume":"13","author":"C Wu","year":"2017","unstructured":"Wu C, Su H, Karydis A, Anderson KM, Ghadri N, Tang S, Wang Y, Bumgardner JD (2017a) Mechanically stable surface-hydrophobilized chitosan nanofibrous barrier membranes for guided bone regeneration. Biomed Mater 13:015004. \nhttps:\/\/doi.org\/10.1088\/1748-605X\/aa853c","journal-title":"Biomed Mater"},{"key":"4_CR145","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1021\/acs.biomac.7b00195","volume":"18","author":"D Wu","year":"2017","unstructured":"Wu D, Samanta A, Srivastava RK, Hakkarainen M (2017b) Starch-derived Nanographene oxide paves the way for Electrospinnable and bioactive starch scaffolds for bone tissue engineering. Biomacromolecules 18:1582\u20131591. \nhttps:\/\/doi.org\/10.1021\/acs.biomac.7b00195","journal-title":"Biomacromolecules"},{"key":"4_CR146","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.foodhyd.2010.03.003","volume":"25","author":"W Xia","year":"2011","unstructured":"Xia W, Liu P, Zhang J, Chen J (2011) Biological activities of chitosan and chitooligosaccharides. Food Hydrocoll 25:170\u2013179. \nhttps:\/\/doi.org\/10.1016\/j.foodhyd.2010.03.003","journal-title":"Food Hydrocoll"},{"issue":"25","key":"4_CR147","doi-asserted-by":"publisher","first-page":"21094","DOI":"10.1021\/acsami.7b01176","volume":"9","author":"Ting Xu","year":"2017","unstructured":"Xu T, Yang H, Yang D, Yu Z-Z (2017) Polylactic acid nanofibers scaffold decorated with Chitosan Island-like topography for bone tissue engineering. ACS Appl Mater Interfaces 9(25):21094\u201321104. \nhttps:\/\/doi.org\/10.1021\/acsami.7b01176","journal-title":"ACS Applied Materials & Interfaces"},{"key":"4_CR148","doi-asserted-by":"publisher","first-page":"8616","DOI":"10.1038\/s41598-017-07759-8","volume":"7","author":"L Yin","year":"2017","unstructured":"Yin L, Wang K, Lv X, Sun R, Yang S, Yang Y, Liu Y, Liu J, Zhou J, Yu Z (2017a) The fabrication of an ICA-SF\/PLCL nanofibrous membrane by coaxial electrospinning and its effect on bone regeneration in vitro and in vivo. Sci Rep 7:8616. \nhttps:\/\/doi.org\/10.1038\/s41598-017-07759-8","journal-title":"Sci Rep"},{"key":"4_CR149","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s10856-017-5898-3","volume":"28","author":"L Yin","year":"2017","unstructured":"Yin L, Yang S, He M, Chang Y, Wang K, Zhu Y, Liu Y, Chang Y, Yu Z (2017b) Physicochemical and biological characteristics of BMP-2\/IGF-1-loaded three-dimensional coaxial electrospun fibrous membranes for bone defect repair. J Mater Sci Mater Med 28:94. \nhttps:\/\/doi.org\/10.1007\/s10856-017-5898-3","journal-title":"J Mater Sci Mater Med"},{"key":"4_CR150","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/jbm.b.31054","volume":"86","author":"H Yu","year":"2008","unstructured":"Yu H, Matthew HW, Wooley PH, Yang SY (2008) Effect of porosity and pore size on microstructures and mechanical properties of poly-\u03b5-caprolactone-hydroxyapatite composites. J Biomed Mater Res B Appl Biomater 86:541\u2013547. \nhttps:\/\/doi.org\/10.1002\/jbm.b.31054","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"4_CR151","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1016\/j.biomaterials.2008.01.022","volume":"29","author":"X Zhang","year":"2008","unstructured":"Zhang X, Baughman CB, Kaplan DL (2008) In vitro evaluation of electrospun silk fibroin scaffolds for vascular cell growth. Biomaterials 29:2217\u20132227. \nhttps:\/\/doi.org\/10.1016\/j.biomaterials.2008.01.022","journal-title":"Biomaterials"},{"key":"4_CR152","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1166\/jbn.2016.2250","volume":"12","author":"X Zhao","year":"2016","unstructured":"Zhao X, Komatsu DE, Hadjiargyrou M (2016) Delivery of rhBMP-2 plasmid DNA complexes via a PLLA\/collagen electrospun scaffold induces ectopic bone formation. J Biomed Nanotechnol 12:1285\u20131296. \nhttps:\/\/doi.org\/10.1166\/jbn.2016.2250","journal-title":"J Biomed Nanotechnol"},{"key":"4_CR153","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.2147\/IJN.S131251","volume":"Volume 12","author":"Ding Zhou","year":"2017","unstructured":"Zhou D, Qi C, Chen Y-X, Zhu Y-J, Sun T-W, Chen F, Zhang C-Q (2017) Comparative study of porous hydroxyapatite\/chitosan and whitlockite\/chitosan scaffolds for bone regeneration in calvarial defects. Int J Nanomedicine 12:2673\u20132687. \nhttps:\/\/doi.org\/10.2147\/IJN.S131251","journal-title":"International Journal of Nanomedicine"},{"key":"4_CR154","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.2147\/IJN.S79241","volume":"10","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Yao H, Wang J, Wang D, Liu Q, Li Z (2015) Greener synthesis of electrospun collagen\/hydroxyapatite composite fibers with an excellent microstructure for bone tissue engineering. Int J Nanomedicine 10:3203. \nhttps:\/\/doi.org\/10.2147\/IJN.S79241","journal-title":"Int J Nanomedicine"},{"key":"4_CR155","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1080\/09205063.2017.1392672","volume":"28","author":"F Zou","year":"2017","unstructured":"Zou F, Li R, Jiang J, Mo X, Gu G, Guo Z, Chen Z (2017) Mechanical enhancement and in vitro biocompatibility of nanofibrous collagen-chitosan scaffolds for tissue engineering. J Biomater Sci Polym Ed 28:2255\u20132270. \nhttps:\/\/doi.org\/10.1080\/09205063.2017.1392672","journal-title":"J Biomater Sci Polym Ed"}],"container-title":["Advances in Experimental Medicine and Biology","Cutting-Edge Enabling Technologies for Regenerative Medicine"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-13-0950-2_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T10:54:24Z","timestamp":1540378464000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-981-13-0950-2_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9789811309496","9789811309502"],"references-count":155,"URL":"https:\/\/doi.org\/10.1007\/978-981-13-0950-2_4","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}