{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:22:41Z","timestamp":1790475761660,"version":"4.1.0"},"publisher-location":"Singapore","reference-count":34,"publisher":"Springer Singapore","isbn-type":[{"value":"9789811313691","type":"print"},{"value":"9789811313707","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/978-981-13-1370-7_3","type":"book-chapter","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T02:53:11Z","timestamp":1539312791000},"page":"39-51","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Entry and Deposit of Aluminum in the Brain"],"prefix":"10.1007","author":[{"given":"Linping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,13]]},"reference":[{"issue":"Suppl 5","key":"3_CR1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1289\/ehp.02110s5699","volume":"110","author":"RA Yokel","year":"2002","unstructured":"Yokel RA (2002) Brain uptake, retention, and efflux of aluminum and manganese. Environ Health Perspect 110(Suppl 5):699\u2013704","journal-title":"Environ Health Perspect"},{"key":"3_CR2","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1021\/jm00180a022","volume":"23","author":"VA Levin","year":"1980","unstructured":"Levin VA (1980) Relationship of octanol\/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23:682\u2013684","journal-title":"J Med Chem"},{"key":"3_CR3","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.clim.2006.06.010","volume":"121","author":"TR Daniels","year":"2006","unstructured":"Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML (2006) The transferrin receptor part I: biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol (Orlando, Fla) 121:144\u2013158","journal-title":"Clin Immunol (Orlando, Fla)"},{"key":"3_CR4","doi-asserted-by":"publisher","first-page":"9024","DOI":"10.1073\/pnas.87.22.9024","volume":"87","author":"AJ Roskams","year":"1990","unstructured":"Roskams AJ, Connor JR (1990) Aluminum access to the brain: a role for transferrin and its receptor. Proc Natl Acad Sci U S A 87:9024\u20139027","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0014-5793(84)80926-6","volume":"176","author":"M Cochran","year":"1984","unstructured":"Cochran M, Coates J, Neoh S (1984) The competitive equilibrium between aluminium and ferric ions for the binding sites of transferrin. FEBS Lett 176:129\u2013132","journal-title":"FEBS Lett"},{"key":"3_CR6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0024-3205(83)80002-2","volume":"33","author":"GA Trapp","year":"1983","unstructured":"Trapp GA (1983) Plasma aluminum is bound to transferrin. Life Sci 33:311\u2013316","journal-title":"Life Sci"},{"key":"3_CR7","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/0140-6736(90)90868-6","volume":"335","author":"G Farrar","year":"1990","unstructured":"Farrar G, Altmann P, Welch S, Wychrij O, Ghose B, Lejeune J et al (1990) Defective gallium-transferrin binding in Alzheimer disease and down syndrome: possible mechanism for accumulation of aluminium in brain. Lancet 335:747\u2013750","journal-title":"Lancet"},{"key":"3_CR8","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2174\/13816128113199990462","volume":"20","author":"N Vijay","year":"2014","unstructured":"Vijay N, Morris ME (2014) Role of monocarboxylate transporters in drug delivery to the brain. Curr Pharm Des 20:1487\u20131498","journal-title":"Curr Pharm Des"},{"key":"3_CR9","first-page":"E253","volume":"245","author":"AR Conn","year":"1983","unstructured":"Conn AR, Fell DI, Steele RD (1983) Characterization of alpha-keto acid transport across blood-brain barrier in rats. Am J Phys 245:E253\u2013E260","journal-title":"Am J Phys"},{"key":"3_CR10","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1152\/ajplegacy.1973.224.6.1450","volume":"224","author":"WH Oldendorf","year":"1973","unstructured":"Oldendorf WH (1973) Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids. Am J Phys 224:1450\u20131453","journal-title":"Am J Phys"},{"key":"3_CR11","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0022-3565(25)20513-4","volume":"258","author":"T Terasaki","year":"1991","unstructured":"Terasaki T, Takakuwa S, Moritani S, Tsuji A (1991) Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells. J Pharmacol Exp Ther 258:932\u2013937","journal-title":"J Pharmacol Exp Ther"},{"key":"3_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0006-8993(02)02234-5","volume":"930","author":"RA Yokel","year":"2002","unstructured":"Yokel RA, Wilson M, Harris WR, Halestrap AP (2002) Aluminum citrate uptake by immortalized brain endothelial cells: implications for its blood-brain barrier transport. Brain Res 930:101\u2013110","journal-title":"Brain Res"},{"key":"3_CR13","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/clinchem\/38.9.1809","volume":"38","author":"WR Harris","year":"1992","unstructured":"Harris WR (1992) Equilibrium model for speciation of aluminum in serum. Clin Chem 38:1809\u20131818","journal-title":"Clin Chem"},{"key":"3_CR14","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/clinchem\/40.4.598","volume":"40","author":"LO Ohman","year":"1994","unstructured":"Ohman LO, Martin RB (1994) Citrate as the main small molecule binding Al3+ in serum. Clin Chem 40:598\u2013601","journal-title":"Clin Chem"},{"key":"3_CR15","doi-asserted-by":"publisher","first-page":"11455","DOI":"10.1074\/jbc.274.17.11455","volume":"274","author":"H Sato","year":"1999","unstructured":"Sato H, Tamba M, Ishii T, Bannai S (1999) Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins. J Biol Chem 274:11455\u201311458","journal-title":"J Biol Chem"},{"key":"3_CR16","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1111\/jnc.13348","volume":"135","author":"A Massie","year":"2015","unstructured":"Massie A, Boillee S, Hewett S, Knackstedt L, Lewerenz J (2015) Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission. J Neurochem 135:1062\u20131079","journal-title":"J Neurochem"},{"key":"3_CR17","doi-asserted-by":"publisher","first-page":"37423","DOI":"10.1074\/jbc.M506439200","volume":"280","author":"H Sato","year":"2005","unstructured":"Sato H, Shiiya A, Kimata M, Maebara K, Tamba M, Sakakura Y et al (2005) Redox imbalance in cystine\/glutamate transporter-deficient mice. J Biol Chem 280:37423\u201337429","journal-title":"J Biol Chem"},{"key":"3_CR18","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1096\/fj.10-177212","volume":"25","author":"A Massie","year":"2011","unstructured":"Massie A, Schallier A, Kim SW, Fernando R, Kobayashi S, Beck H et al (2011) Dopaminergic neurons of system x(c)(-)-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity. FASEB J 25:1359\u20131369","journal-title":"FASEB J"},{"key":"3_CR19","doi-asserted-by":"publisher","first-page":"5792","DOI":"10.1523\/JNEUROSCI.5465-10.2011","volume":"31","author":"D Bundel De","year":"2011","unstructured":"De Bundel D, Schallier A, Loyens E, Fernando R, Miyashita H, Van Liefferinge J et al (2011) Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. J Neurosci 31:5792\u20135803","journal-title":"J Neurosci"},{"key":"3_CR20","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s004240100537","volume":"442","author":"MT Bassi","year":"2001","unstructured":"Bassi MT, Gasol E, Manzoni M, Pineda M, Riboni M, Martin R et al (2001) Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc. Pflugers Archiv 442:286\u2013296","journal-title":"Pflugers Archiv"},{"key":"3_CR21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.toxlet.2004.10.004","volume":"155","author":"K Nagasawa","year":"2005","unstructured":"Nagasawa K, Ito S, Kakuda T, Nagai K, Tamai I, Tsuji A et al (2005) Transport mechanism for aluminum citrate at the blood-brain barrier: kinetic evidence implies involvement of system Xc- in immortalized rat brain endothelial cells. Toxicol Lett 155:289\u2013296","journal-title":"Toxicol Lett"},{"key":"3_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","volume":"65","author":"NC Danbolt","year":"2001","unstructured":"Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1\u2013105","journal-title":"Prog Neurobiol"},{"key":"3_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1124\/jpet.302.1.225","volume":"302","author":"K Hosoya","year":"2002","unstructured":"Hosoya K, Tomi M, Ohtsuki S, Takanaga H, Saeki S, Kanai Y et al (2002) Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment. J Pharmacol Exp Ther 302:225\u2013231","journal-title":"J Pharmacol Exp Ther"},{"key":"3_CR24","doi-asserted-by":"publisher","first-page":"4904","DOI":"10.1046\/j.1432-1327.2000.01595.x","volume":"267","author":"JB Schulz","year":"2000","unstructured":"Schulz JB, Lindenau J, Seyfried J, Dichgans J (2000) Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 267:4904\u20134911","journal-title":"Eur J Biochem"},{"key":"3_CR25","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/S0140-6736(87)92288-4","volume":"1","author":"DP Perl","year":"1987","unstructured":"Perl DP, Good PF (1987) Uptake of aluminium into central nervous system along nasal-olfactory pathways. Lancet 1:1028","journal-title":"Lancet"},{"key":"3_CR26","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1111\/j.1471-4159.1992.tb09342.x","volume":"58","author":"DD Allen","year":"1992","unstructured":"Allen DD, Yokel RA (1992) Dissimilar aluminum and gallium permeation of the blood-brain barrier demonstrated by in vivo microdialysis. J Neurochem 58:903\u2013908","journal-title":"J Neurochem"},{"key":"3_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0162-0134(99)00124-5","volume":"76","author":"RA Yokel","year":"1999","unstructured":"Yokel RA, Allen DD, Ackley DC (1999) The distribution of aluminum into and out of the brain. J Inorg Biochem 76:127\u2013132","journal-title":"J Inorg Biochem"},{"key":"3_CR28","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0272-6386(85)80082-2","volume":"6","author":"SM Ott","year":"1985","unstructured":"Ott SM (1985) Aluminum accumulation in individuals with normal renal function. Am J Kidney Dis 6:297\u2013301","journal-title":"Am J Kidney Dis"},{"key":"3_CR29","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/S0140-6736(83)91273-4","volume":"2","author":"WA Banks","year":"1983","unstructured":"Banks WA, Kastin AJ (1983) Aluminium increases permeability of the blood-brain barrier to labelled DSIP and beta-endorphin: possible implications for senile and dialysis dementia. Lancet 2:1227\u20131229","journal-title":"Lancet"},{"key":"3_CR30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neulet.2008.08.081","volume":"445","author":"Y Song","year":"2008","unstructured":"Song Y, Xue Y, Liu X, Wang P, Liu L (2008) Effects of acute exposure to aluminum on blood-brain barrier and the protection of zinc. Neurosci Lett 445:42\u201346","journal-title":"Neurosci Lett"},{"key":"3_CR31","first-page":"12","volume":"42","author":"X Liu","year":"2008","unstructured":"Liu X, Liu LB, Liu YH, Xue YX (2008) Effects of aluminum on the integrity of blood brain barrier in juvenile rats. Zhonghua yu fang yi xue za zhi [Chin J Prev Med] 42:12\u201315","journal-title":"Zhonghua yu fang yi xue za zhi [Chin J Prev Med]"},{"key":"3_CR32","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/BF00690191","volume":"68","author":"GY Wen","year":"1985","unstructured":"Wen GY, Wisniewski HM (1985) Histochemical localization of aluminum in the rabbit CNS. Acta Neuropathol 68:175\u2013184","journal-title":"Acta Neuropathol"},{"key":"3_CR33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0149-7634(89)80051-X","volume":"13","author":"WA Banks","year":"1989","unstructured":"Banks WA, Kastin AJ (1989) Aluminum-induced neurotoxicity: alterations in membrane function at the blood-brain barrier. Neurosci Biobehav Rev 13:47\u201353","journal-title":"Neurosci Biobehav Rev"},{"key":"3_CR34","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/0278-6915(84)90369-7","volume":"22","author":"P Slanina","year":"1984","unstructured":"Slanina P, Falkeborn Y, Frech W, Cedergren A (1984) Aluminium concentrations in the brain and bone of rats fed citric acid, aluminium citrate or aluminium hydroxide. Food Chem Toxicol 22:391\u2013397","journal-title":"Food Chem Toxicol"}],"container-title":["Advances in Experimental Medicine and Biology","Neurotoxicity of Aluminum"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-13-1370-7_3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:37:56Z","timestamp":1775245076000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/978-981-13-1370-7_3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9789811313691","9789811313707"],"references-count":34,"URL":"https:\/\/doi.org\/10.1007\/978-981-13-1370-7_3","relation":{},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"13 October 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}