{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T06:45:10Z","timestamp":1794638710797,"version":"4.9.1"},"publisher-location":"Singapore","reference-count":79,"publisher":"Springer Singapore","isbn-type":[{"value":"9789811560811","type":"print"},{"value":"9789811560828","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/978-981-15-6082-8_14","type":"book-chapter","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T02:58:13Z","timestamp":1595473093000},"page":"223-234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Mfsd2a: A Physiologically Important Lysolipid Transporter in the Brain and Eye"],"prefix":"10.1007","author":[{"given":"Bernice H.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"14_CR1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1126\/science.1088196","volume":"301","author":"J Abramson","year":"2003","unstructured":"Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S (2003) Structure and mechanism of the lactose permease of Escherichia coli. Science 301:610\u2013615","journal-title":"Science"},{"key":"14_CR2","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/ng.3313","volume":"47","author":"V Alakbarzade","year":"2015","unstructured":"Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL, Cazenave-Gassiot A, Nguyen LN, Wenk MR, Ahmad AQ, Sreekantan-Nair A et al (2015) A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. Nat Genet 47:814\u2013817","journal-title":"Nat Genet"},{"key":"14_CR3","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41586-019-1326-9","volume":"571","author":"F Alfei","year":"2019","unstructured":"Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y et al (2019) TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature 571:265\u2013269","journal-title":"Nature"},{"key":"14_CR4","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.neuron.2017.03.043","volume":"94","author":"BJ Andreone","year":"2017","unstructured":"Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, Deik AA, Ginty DD, Clish CB, Gu C (2017) Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis. Neuron 94:581\u2013594. e585","journal-title":"Neuron"},{"key":"14_CR5","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1042\/BJ20080165","volume":"416","author":"M Angers","year":"2008","unstructured":"Angers M, Uldry M, Kong D, Gimble JM, Jetten AM (2008) Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J 416:347\u2013355","journal-title":"Biochem J"},{"key":"14_CR6","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nature09522","volume":"468","author":"A Armulik","year":"2010","unstructured":"Armulik A, Genove G, Mae M, Nisancioglu MH, Wallgard E, Niaudet C, He L, Norlin J, Lindblom P, Strittmatter K et al (2010) Pericytes regulate the blood-brain barrier. Nature 468:557\u2013561","journal-title":"Nature"},{"key":"14_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s11745-016-4130-4","volume":"51","author":"ML Baack","year":"2016","unstructured":"Baack ML, Puumala SE, Messier SE, Pritchett DK, Harris WS (2016) Daily enteral DHA supplementation alleviates deficiency in premature infants. Lipids 51:423\u2013433","journal-title":"Lipids"},{"key":"14_CR8","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1152\/physrev.2001.81.2.871","volume":"81","author":"N Baumann","year":"2001","unstructured":"Baumann N, Pham-Dinh D (2001) Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81:871\u2013927","journal-title":"Physiol Rev"},{"key":"14_CR9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.tins.2006.03.005","volume":"29","author":"NG Bazan","year":"2006","unstructured":"Bazan NG (2006) Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci 29:263\u2013271","journal-title":"Trends Neurosci"},{"key":"14_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature13324","volume":"509","author":"A Ben-Zvi","year":"2014","unstructured":"Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, Gu C (2014) Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature 509:507\u2013511","journal-title":"Nature"},{"key":"14_CR11","doi-asserted-by":"publisher","first-page":"e50629","DOI":"10.1371\/journal.pone.0050629","volume":"7","author":"JH Berger","year":"2012","unstructured":"Berger JH, Charron MJ, Silver DL (2012) Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism. PLoS One 7:e50629","journal-title":"PLoS One"},{"key":"14_CR12","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/ng.3348","volume":"47","author":"C Betsholtz","year":"2015","unstructured":"Betsholtz C (2015) Lipid transport and human brain development. Nat Genet 47:699\u2013701","journal-title":"Nat Genet"},{"key":"14_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0361-9230(01)00551-2","volume":"56","author":"JD Carver","year":"2001","unstructured":"Carver JD, Benford VJ, Han B, Cantor AB (2001) The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Res Bull 56:79\u201385","journal-title":"Brain Res Bull"},{"key":"14_CR14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0047-6374(01)00356-6","volume":"123","author":"A Catalani","year":"2002","unstructured":"Catalani A, Sabbatini M, Consoli C, Cinque C, Tomassoni D, Azmitia E, Angelucci L, Amenta F (2002) Glial fibrillary acidic protein immunoreactive astrocytes in developing rat hippocampus. Mech Ageing Dev 123:481\u2013490","journal-title":"Mech Ageing Dev"},{"key":"14_CR15","doi-asserted-by":"publisher","first-page":"e2006443","DOI":"10.1371\/journal.pbio.2006443","volume":"16","author":"JP Chan","year":"2018","unstructured":"Chan JP, Wong BH, Chin CF, Galam DLA, Foo JC, Wong LC, Ghosh S, Wenk MR, Cazenave-Gassiot A, Silver DL (2018) The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain. PLoS Biol 16:e2006443","journal-title":"PLoS Biol"},{"key":"14_CR16","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.neuron.2017.02.043","volume":"93","author":"BW Chow","year":"2017","unstructured":"Chow BW, Gu C (2017) Gradual suppression of transcytosis governs functional blood-retinal barrier formation. Neuron 93:1325\u20131333. e1323","journal-title":"Neuron"},{"key":"14_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0378-3782(81)90016-5","volume":"5","author":"MT Clandinin","year":"1981","unstructured":"Clandinin MT, Chappell JE, Heim T, Swyer PR, Chance GW (1981) Fatty acid utilization in perinatal de novo synthesis of tissues. Early Hum Dev 5:355\u2013366","journal-title":"Early Hum Dev"},{"key":"14_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plefa.2015.04.003","volume":"99","author":"CT Collins","year":"2015","unstructured":"Collins CT, Sullivan TR, McPhee AJ, Stark MJ, Makrides M, Gibson RA (2015) A dose response randomised controlled trial of docosahexaenoic acid (DHA) in preterm infants. Prostaglandins Leukot Essent Fat Acids 99:1\u20136","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"14_CR19","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/j.1467-8624.2004.00737.x","volume":"75","author":"J Colombo","year":"2004","unstructured":"Colombo J, Kannass KN, Shaddy DJ, Kundurthi S, Maikranz JM, Anderson CJ, Blaga OM, Carlson SE (2004) Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev 75:1254\u20131267","journal-title":"Child Dev"},{"issue":"Pt 1","key":"14_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1042\/bj3450061","volume":"345","author":"M Croset","year":"2000","unstructured":"Croset M, Brossard N, Polette A, Lagarde M (2000) Characterization of plasma unsaturated lysophosphatidylcholines in human and rat. Biochem J 345(Pt 1):61\u201367","journal-title":"Biochem J"},{"key":"14_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0039-6257(79)90158-9","volume":"23","author":"J Cunha-Vaz","year":"1979","unstructured":"Cunha-Vaz J (1979) The blood-ocular barriers. Surv Ophthalmol 23:279\u2013296","journal-title":"Surv Ophthalmol"},{"key":"14_CR22","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1136\/bjo.50.8.441","volume":"50","author":"JG Cunha-Vaz","year":"1966","unstructured":"Cunha-Vaz JG, Shakib M, Ashton N (1966) Studies on the permeability of the blood-retinal barrier. I. On the existence, development, and site of a blood-retinal barrier. Br J Ophthalmol 50:441\u2013453","journal-title":"Br J Ophthalmol"},{"key":"14_CR23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11745-000-0501-6","volume":"35","author":"SC Cunnane","year":"2000","unstructured":"Cunnane SC, Francescutti V, Brenna JT, Crawford MA (2000) Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids 35:105\u2013111","journal-title":"Lipids"},{"key":"14_CR24","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nature09513","volume":"468","author":"R Daneman","year":"2010","unstructured":"Daneman R, Zhou L, Kebede AA, Barres BA (2010) Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468:562\u2013566","journal-title":"Nature"},{"key":"14_CR25","doi-asserted-by":"crossref","unstructured":"Delgado-Noguera MF, Calvache JA, Bonfill Cosp X (2010) Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development Cochrane Database Syst Rev:CD007901","DOI":"10.1002\/14651858.CD007901.pub2"},{"key":"14_CR26","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nature14655","volume":"526","author":"D Deng","year":"2015","unstructured":"Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, Ren W, Hirata K, Yamamoto M, Fan S et al (2015) Molecular basis of ligand recognition and transport by glucose transporters. Nature 526:391\u2013396","journal-title":"Nature"},{"key":"14_CR27","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nature13306","volume":"510","author":"D Deng","year":"2014","unstructured":"Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, Yan N (2014) Crystal structure of the human glucose transporter GLUT1. Nature 510:121\u2013125","journal-title":"Nature"},{"key":"14_CR28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","volume":"3","author":"J Dobbing","year":"1979","unstructured":"Dobbing J, Sands J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3:79\u201383","journal-title":"Early Hum Dev"},{"key":"14_CR29","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1038\/ncomms4009","volume":"5","author":"AS Ethayathulla","year":"2014","unstructured":"Ethayathulla AS, Yousef MS, Amin A, Leblanc G, Kaback HR, Guan L (2014) Structure-based mechanism for Na(+)\/melibiose symport by MelB. Nat Commun 5:3009","journal-title":"Nat Commun"},{"key":"14_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0163-7827(83)90004-8","volume":"22","author":"SJ Fliesler","year":"1983","unstructured":"Fliesler SJ, Anderson RE (1983) Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipid Res 22:79\u2013131","journal-title":"Prog Lipid Res"},{"key":"14_CR31","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3945\/ajcn.112.045781","volume":"97","author":"JF Gould","year":"2013","unstructured":"Gould JF, Smithers LG, Makrides M (2013) The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 97:531\u2013544","journal-title":"Am J Clin Nutr"},{"key":"14_CR32","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/ng.3311","volume":"47","author":"A Guemez-Gamboa","year":"2015","unstructured":"Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E et al (2015) Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nat Genet 47:809\u2013813","journal-title":"Nat Genet"},{"key":"14_CR33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.biochi.2010.05.005","volume":"93","author":"P Guesnet","year":"2011","unstructured":"Guesnet P, Alessandri JM (2011) Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) \u2013 implications for dietary recommendations. Biochimie 93:7\u201312","journal-title":"Biochimie"},{"key":"14_CR34","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10048-018-0556-6","volume":"19","author":"T Harel","year":"2018","unstructured":"Harel T, Quek DQY, Wong BH, Cazenave-Gassiot A, Wenk MR, Fan H, Berger I, Shmueli D, Shaag A, Silver DL et al (2018) Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination. Neurogenetics 19:227\u2013235","journal-title":"Neurogenetics"},{"key":"14_CR35","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1146\/annurev.nutr.24.012003.132254","volume":"25","author":"WC Heird","year":"2005","unstructured":"Heird WC, Lapillonne A (2005) The role of essential fatty acids in development. Annu Rev Nutr 25:549\u2013571","journal-title":"Annu Rev Nutr"},{"key":"14_CR36","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1126\/science.1087619","volume":"301","author":"Y Huang","year":"2003","unstructured":"Huang Y, Lemieux MJ, Song J, Auer M, Wang DN (2003) Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301:616\u2013620","journal-title":"Science"},{"key":"14_CR37","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1042\/bj1300557","volume":"130","author":"DR Illingworth","year":"1972","unstructured":"Illingworth DR, Portman OW (1972) The uptake and metabolism of plasma lysophosphatidylcholine in vivo by the brain of squirrel monkeys. Biochem J 130:557\u2013567","journal-title":"Biochem J"},{"issue":"Suppl A","key":"14_CR38","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.1016\/j.placenta.2005.01.005","volume":"26","author":"SM Innis","year":"2005","unstructured":"Innis SM (2005) Essential fatty acid transfer and fetal development. Placenta 26(Suppl A):S70\u2013S75","journal-title":"Placenta"},{"key":"14_CR39","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1126\/science.1167449","volume":"323","author":"A Kawahara","year":"2009","unstructured":"Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N (2009) The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science 323:524\u2013527","journal-title":"Science"},{"key":"14_CR40","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41586-019-1325-x","volume":"571","author":"O Khan","year":"2019","unstructured":"Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, Werner MT, Huang AC, Alexander KA, Wu JE et al (2019) TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion. Nature 571:211\u2013218","journal-title":"Nature"},{"key":"14_CR41","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.neuropharm.2008.02.019","volume":"55","author":"Z Korade","year":"2008","unstructured":"Korade Z, Kenworthy AK (2008) Lipid rafts, cholesterol, and the brain. Neuropharmacology 55:1265\u20131273","journal-title":"Neuropharmacology"},{"key":"14_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","volume":"32","author":"A Kriegstein","year":"2009","unstructured":"Kriegstein A, Alvarez-Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32:149\u2013184","journal-title":"Annu Rev Neurosci"},{"key":"14_CR43","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1385\/JMN:16:2-3:201","volume":"16","author":"M Lagarde","year":"2001","unstructured":"Lagarde M, Bernoud N, Brossard N, Lemaitre-Delaunay D, Thies F, Croset M, Lecerf J (2001) Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain. J Mol Neurosci 16:201\u2013204; discussion 215-221","journal-title":"J Mol Neurosci"},{"key":"14_CR44","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1016\/S0021-9258(18)64604-6","volume":"235","author":"WE Lands","year":"1960","unstructured":"Lands WE (1960) Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin. J Biol Chem 235:2233\u20132237","journal-title":"J Biol Chem"},{"key":"14_CR45","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.micro.61.080706.093329","volume":"62","author":"CJ Law","year":"2008","unstructured":"Law CJ, Maloney PC, Wang DN (2008) Ins and outs of major facilitator superfamily antiporters. Annu Rev Microbiol 62:289\u2013305","journal-title":"Annu Rev Microbiol"},{"key":"14_CR46","doi-asserted-by":"publisher","first-page":"9689","DOI":"10.1523\/JNEUROSCI.1142-19.2019","volume":"39","author":"ES Lobanova","year":"2019","unstructured":"Lobanova ES, Schuhmann K, Finkelstein S, Lewis TR, Cady MA, Hao Y, Keuthan C, Ash JD, Burns ME, Shevchenko A et al (2019) Disrupted blood-retina lysophosphatidylcholine transport impairs photoreceptor health but not visual signal transduction. J Neurosci 39:9689\u20139701","journal-title":"J Neurosci"},{"key":"14_CR47","doi-asserted-by":"publisher","first-page":"S129","DOI":"10.1016\/S0022-3476(05)81247-8","volume":"120","author":"M Martinez","year":"1992","unstructured":"Martinez M (1992) Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 120:S129\u2013S138","journal-title":"J Pediatr"},{"issue":"Suppl","key":"14_CR48","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1007\/BF02637067","volume":"31","author":"M Martinez","year":"1996","unstructured":"Martinez M (1996) Docosahexaenoic acid therapy in docosahexaenoic acid-deficient patients with disorders of peroxisomal biogenesis. Lipids 31(Suppl):S145\u2013S152","journal-title":"Lipids"},{"key":"14_CR49","doi-asserted-by":"publisher","first-page":"864","DOI":"10.3945\/jn.109.113233","volume":"140","author":"RK McNamara","year":"2010","unstructured":"McNamara RK (2010) DHA deficiency and prefrontal cortex neuropathology in recurrent affective disorders. J Nutr 140:864\u2013868","journal-title":"J Nutr"},{"key":"14_CR50","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.plefa.2008.04.001","volume":"78","author":"RK McNamara","year":"2008","unstructured":"McNamara RK, Liu Y, Jandacek R, Rider T, Tso P (2008) The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins Leukot Essent Fat Acids 78:293\u2013304","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"14_CR51","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/(SICI)1096-9861(19960923)373:3<340::AID-CNE3>3.0.CO;2-2","volume":"373","author":"KD Micheva","year":"1996","unstructured":"Micheva KD, Beaulieu C (1996) Quantitative aspects of synaptogenesis in the rat barrel field cortex with special reference to GABA circuitry. J Comp Neurol 373:340\u2013354","journal-title":"J Comp Neurol"},{"key":"14_CR52","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature13241","volume":"509","author":"LN Nguyen","year":"2014","unstructured":"Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL (2014) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509:503\u2013506","journal-title":"Nature"},{"key":"14_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MMBR.62.1.1-34.1998","volume":"62","author":"SS Pao","year":"1998","unstructured":"Pao SS, Paulsen IT, Saier MH Jr (1998) Major facilitator superfamily. Microbiol Mol Biol Rev 62:1\u201334","journal-title":"Microbiol Mol Biol Rev"},{"key":"14_CR54","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4049\/jimmunol.1801585","volume":"203","author":"AR Piccirillo","year":"2019","unstructured":"Piccirillo AR, Hyzny EJ, Beppu LY, Menk AV, Wallace CT, Hawse WF, Buechel HM, Wong BH, Foo JC, Cazenave-Gassiot A et al (2019) The lysophosphatidylcholine transporter MFSD2A is essential for CD8(+) memory T cell maintenance and secondary response to infection. J Immunol 203:117\u2013126","journal-title":"J Immunol"},{"key":"14_CR55","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1542\/peds.2011-2127","volume":"129","author":"A Qawasmi","year":"2012","unstructured":"Qawasmi A, Landeros-Weisenberger A, Leckman JF, Bloch MH (2012) Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition. Pediatrics 129:1141\u20131149","journal-title":"Pediatrics"},{"key":"14_CR56","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1194\/jlr.M009449","volume":"51","author":"O Quehenberger","year":"2010","unstructured":"Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL et al (2010) Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 51:3299\u20133305","journal-title":"J Lipid Res"},{"key":"14_CR57","doi-asserted-by":"publisher","first-page":"9383","DOI":"10.1074\/jbc.M116.721035","volume":"291","author":"DQ Quek","year":"2016","unstructured":"Quek DQ, Nguyen LN, Fan H, Silver DL (2016) Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a. J Biol Chem 291:9383\u20139394","journal-title":"J Biol Chem"},{"key":"14_CR58","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.preteyeres.2004.06.002","volume":"24","author":"JP SanGiovanni","year":"2005","unstructured":"SanGiovanni JP, Chew EY (2005) The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res 24:87\u2013138","journal-title":"Prog Retin Eye Res"},{"key":"14_CR59","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0014-4835(66)80011-8","volume":"5","author":"M Shakib","year":"1966","unstructured":"Shakib M, Cunha-Vaz JG (1966) Studies on the permeability of the blood-retinal barrier. IV. Junctional complexes of the retinal vessels and their role in the permeability of the blood-retinal barrier. Exp Eye Res 5:229\u2013234","journal-title":"Exp Eye Res"},{"key":"14_CR60","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-biophys-083012-130429","volume":"42","author":"Y Shi","year":"2013","unstructured":"Shi Y (2013) Common folds and transport mechanisms of secondary active transporters. Annu Rev Biophys 42:51\u201372","journal-title":"Annu Rev Biophys"},{"key":"14_CR61","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.neuron.2015.12.008","volume":"89","author":"JC Silbereis","year":"2016","unstructured":"Silbereis JC, Pochareddy S, Zhu Y, Li M, Sestan N (2016) The cellular and molecular landscapes of the developing human central nervous system. Neuron 89:248\u2013268","journal-title":"Neuron"},{"key":"14_CR62","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3181\/0711-MR-311","volume":"233","author":"AP Simopoulos","year":"2008","unstructured":"Simopoulos AP (2008) The importance of the omega-6\/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood) 233:674\u2013688","journal-title":"Exp Biol Med (Maywood)"},{"key":"14_CR63","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/BF00158922","volume":"60","author":"RH Steinberg","year":"1985","unstructured":"Steinberg RH (1985) Interactions between the retinal pigment epithelium and the neural retina. Doc Ophthalmol 60:327\u2013346","journal-title":"Doc Ophthalmol"},{"key":"14_CR64","doi-asserted-by":"publisher","first-page":"11263","DOI":"10.1038\/s41598-017-11766-0","volume":"7","author":"D Sugasini","year":"2017","unstructured":"Sugasini D, Thomas R, Yalagala PCR, Tai LM, Subbaiah PV (2017) Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice. Sci Rep 7:11263","journal-title":"Sci Rep"},{"key":"14_CR65","doi-asserted-by":"publisher","first-page":"e1001532","DOI":"10.1371\/journal.pbio.1001532","volume":"11","author":"R Suzuki","year":"2013","unstructured":"Suzuki R, Ferris HA, Chee MJ, Maratos-Flier E, Kahn CR (2013) Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function. PLoS Biol 11:e1001532","journal-title":"PLoS Biol"},{"key":"14_CR66","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/S0022-2275(20)42702-6","volume":"9","author":"L Svennerholm","year":"1968","unstructured":"Svennerholm L (1968) Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res 9:570\u2013579","journal-title":"J Lipid Res"},{"key":"14_CR67","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S0022-2275(20)39614-0","volume":"6","author":"S Switzer","year":"1965","unstructured":"Switzer S, Eder HA (1965) Transport of lysolecithin by albumin in human and rat plasma. J Lipid Res 6:506\u2013511","journal-title":"J Lipid Res"},{"key":"14_CR68","doi-asserted-by":"crossref","unstructured":"Tabula Muris C, Overall c, Logistical c, Organ c, processing, Library, p., sequencing, Computational data a, Cell type a, Writing g et al (2018) Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562:367\u2013372","DOI":"10.1038\/s41586-018-0590-4"},{"key":"14_CR69","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1111\/j.1471-4159.1992.tb08353.x","volume":"59","author":"F Thies","year":"1992","unstructured":"Thies F, Delachambre MC, Bentejac M, Lagarde M, Lecerf J (1992) Unsaturated fatty acids esterified in 2-acyl-l-lysophosphatidylcholine bound to albumin are more efficiently taken up by the young rat brain than the unesterified form. J Neurochem 59:1110\u20131116","journal-title":"J Neurochem"},{"key":"14_CR70","first-page":"R1273","volume":"267","author":"F Thies","year":"1994","unstructured":"Thies F, Pillon C, Moliere P, Lagarde M, Lecerf J (1994) Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. Am J Phys 267:R1273\u2013R1279","journal-title":"Am J Phys"},{"key":"14_CR71","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/glia.23120","volume":"65","author":"AF van Deijk","year":"2017","unstructured":"van Deijk AF, Camargo N, Timmerman J, Heistek T, Brouwers JF, Mogavero F, Mansvelder HD, Smit AB, Verheijen MH (2017) Astrocyte lipid metabolism is critical for synapse development and function in vivo. Glia 65:670\u2013682","journal-title":"Glia"},{"key":"14_CR72","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature25739","volume":"560","author":"M Vanlandewijck","year":"2018","unstructured":"Vanlandewijck M, He L, Mae MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Lavina B, Gouveia L et al (2018) A molecular atlas of cell types and zonation in the brain vasculature. Nature 560:475\u2013480","journal-title":"Nature"},{"key":"14_CR73","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature24053","volume":"550","author":"TM Vu","year":"2017","unstructured":"Vu TM, Ishizu AN, Foo JC, Toh XR, Zhang F, Whee DM, Torta F, Cazenave-Gassiot A, Matsumura T, Kim S et al (2017) Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. Nature 550:524\u2013528","journal-title":"Nature"},{"key":"14_CR74","doi-asserted-by":"publisher","first-page":"10501","DOI":"10.1074\/jbc.M116.721340","volume":"291","author":"BH Wong","year":"2016","unstructured":"Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW et al (2016) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid (DHA) in eye and is important for photoreceptor cell development. J Biol Chem 291:10501\u201310514","journal-title":"J Biol Chem"},{"key":"14_CR75","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-biophys-060414-033901","volume":"44","author":"N Yan","year":"2015","unstructured":"Yan N (2015) Structural biology of the major facilitator superfamily transporters. Annu Rev Biophys 44:257\u2013283","journal-title":"Annu Rev Biophys"},{"key":"14_CR76","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1083\/jcb.33.1.61","volume":"33","author":"RW Young","year":"1967","unstructured":"Young RW (1967) The renewal of photoreceptor cell outer segments. J Cell Biol 33:61\u201372","journal-title":"J Cell Biol"},{"key":"14_CR77","first-page":"700","volume":"15","author":"RW Young","year":"1976","unstructured":"Young RW (1976) Visual cells and the concept of renewal. Invest Ophthalmol Vis Sci 15:700\u2013725","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"14_CR78","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1194\/jlr.R018689","volume":"52","author":"SG Young","year":"2011","unstructured":"Young SG, Davies BS, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP (2011) GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res 52:1869\u20131884","journal-title":"J Lipid Res"},{"key":"14_CR79","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O\u2019Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N et al (2014) An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34:11929\u201311947","journal-title":"J Neurosci"}],"container-title":["Advances in Experimental Medicine and Biology","Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-15-6082-8_14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T22:04:53Z","timestamp":1649973893000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-981-15-6082-8_14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9789811560811","9789811560828"],"references-count":79,"URL":"https:\/\/doi.org\/10.1007\/978-981-15-6082-8_14","relation":{"is-part-of":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1007\/978-981-15-6082-8","asserted-by":"object"}]},"ISSN":["0065-2598","2214-8019"],"issn-type":[{"value":"0065-2598","type":"print"},{"value":"2214-8019","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"24 July 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}