{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:54:20Z","timestamp":1791240860262,"version":"4.1.0"},"publisher-location":"Singapore","reference-count":141,"publisher":"Springer Nature Singapore","isbn-type":[{"value":"9789819259632","type":"print"},{"value":"9789819259649","type":"electronic"}],"license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2027]]},"DOI":"10.1007\/978-981-92-5964-9_9","type":"book-chapter","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:12:24Z","timestamp":1791238344000},"page":"203-252","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AA in Rheumatoid Arthritis and Lupus"],"prefix":"10.1007","author":[{"given":"Undurti N.","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"9_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1365-2567.2011.03478.x","volume":"134","author":"C Alvarez","year":"2011","unstructured":"Alvarez C, Amaral MM, Langellotti C, Vermeulen M (2011) Leukotriene C(4) prevents the complete maturation of murine dendritic cells and modifies interleukin-12\/interleukin-23 balance. Immunology 134:185\u2013197","journal-title":"Immunology"},{"key":"9_CR2","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1002\/art.40002","volume":"69","author":"J An","year":"2017","unstructured":"An J, Durcan L, Karr RM, Briggs TA, Rice GI, Teal TH et al (2017) Expression of cyclic GMP-AMP synthase in patients with systemic lupus erythematosus. Arthritis Rheumatol (Hoboken NJ) 69:800\u2013807","journal-title":"Arthritis Rheumatol (Hoboken NJ)"},{"issue":"12","key":"9_CR3","doi-asserted-by":"publisher","first-page":"6266","DOI":"10.4049\/jimmunol.170.12.6266","volume":"170","author":"A Ariel","year":"2003","unstructured":"Ariel A, Chiang N, Arita M, Petasis NA, Serhan CN (2003) Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase dependent TNF-alpha secretion from human T cells. J Immunol 170(12):6266\u20136272","journal-title":"J Immunol"},{"issue":"8","key":"9_CR4","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.4049\/jimmunol.1401313","volume":"193","author":"HH Arnardottir","year":"2014","unstructured":"Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CN (2014) Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. J Immunol 193(8):4235\u20134244","journal-title":"J Immunol"},{"issue":"1","key":"9_CR5","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12944-019-1164-7","volume":"18","author":"S Bathina","year":"2019","unstructured":"Bathina S, Das UN (2019) PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo. Lipids Health Dis 18(1):214","journal-title":"Lipids Health Dis"},{"key":"9_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041516","volume":"22","author":"S Bathina","year":"2021","unstructured":"Bathina S, Das UN (2021) Resolvin D1 decreases severity of Streptozotocin-induced type 1 diabetes mellitus by enhancing BDNF levels, reducing oxidative stress, and suppressing inflammation. Int J Mol Sci 22:1516","journal-title":"Int J Mol Sci"},{"key":"9_CR7","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.arcmed.2020.05.002","volume":"51","author":"S Bathina","year":"2020","unstructured":"Bathina S, Gundala NK, Rhenghachar P, Polavarapu S, Hari AD, Sadananda M, Das UN (2020) Resolvin D1 ameliorates nicotinamide-streptozotocin-induced type 2 diabetes mellitus by its anti-inflammatory action and modulating PI3K\/Akt\/mTOR pathway in the brain. Arch Med Res 51:492\u2013503","journal-title":"Arch Med Res"},{"issue":"6528","key":"9_CR8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1126\/science.abf9566","volume":"371","author":"F Becker","year":"2021","unstructured":"Becker F, Rudolph KL (2021) Targeting enzyme aging. Science 371(6528):462\u2013463","journal-title":"Science"},{"key":"9_CR9","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1172\/JCI87388","volume":"127","author":"X Bi","year":"2017","unstructured":"Bi X, Li F, Liu S, Jin Y, Zhang X, Yang T, Dai Y, Li X, Zhao AZ (2017) \u03c9-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest 127:1757\u20131771","journal-title":"J Clin Invest"},{"issue":"2","key":"9_CR10","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1681\/ASN.V32128","volume":"3","author":"JV Bonventre","year":"1992","unstructured":"Bonventre JV (1992) Phospholipase A2 and signal transduction. J Am Soc Nephrol 3(2):128\u2013150","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"9_CR11","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0006-291X(86)90009-4","volume":"135","author":"JC Bordet","year":"1986","unstructured":"Bordet JC, Guichardant M, Lagarde M (1986) Arachidonic acid strongly stimulates prostaglandin I3 (PGI3) production from eicosapentaenoic acid in human endothelial cells. Biochem Biophys Res Commun 135(2):403\u2013410","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"9_CR12","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/0005-2760(88)90232-9","volume":"958","author":"JC Bordet","year":"1988","unstructured":"Bordet JC, Guichardant M, Lagarde M (1988) Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. Biochim Biophys Acta 958(3):460\u2013468","journal-title":"Biochim Biophys Acta"},{"issue":"6544","key":"9_CR13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/377068a0","volume":"377","author":"T Calandra","year":"1995","unstructured":"Calandra T, Bernhagen J, Metz CN et al (1995) MIF as a glucocorticoid-induced modulator of cytokine production. Nature 377(6544):68\u201371","journal-title":"Nature"},{"key":"9_CR14","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s10753-016-0358-7","volume":"39","author":"D Cao","year":"2016","unstructured":"Cao D, Luo J, Zang W, Chen D, Xu H, Shi H, Jing X (2016) Gamma-Linolenic acid suppresses NF-B signaling via CD36 in the lipopolysaccharide-induced inflammatory response in primary goat mammary gland epithelial cells. Inflammation 39:1225\u20131237","journal-title":"Inflammation"},{"key":"9_CR15","doi-asserted-by":"publisher","first-page":"6418","DOI":"10.4049\/jimmunol.0903816","volume":"184","author":"MM-Y Chan","year":"2010","unstructured":"Chan MM-Y, Moore AR (2010) Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production. J Immunol 184:6418\u20136426","journal-title":"J Immunol"},{"issue":"1","key":"9_CR16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s10753-009-9157-8","volume":"33","author":"CS Chang","year":"2010","unstructured":"Chang CS, Sun HL, Lii CK, Chen HW, Chen PY, Liu KL (2010a) Gamma-linolenic acid inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. Inflammation 33(1):46\u201357","journal-title":"Inflammation"},{"key":"9_CR17","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s10753-009-9157-8","volume":"33","author":"C-S Chang","year":"2010","unstructured":"Chang C-S, Sun H-L, Lii C-K, Chen H-W, Chen P-Y, Liu K-L (2010b) Gamma-Linolenic acid inhibits inflammatory responses by regulating NF-B and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. Inflammation 33:46\u201357","journal-title":"Inflammation"},{"key":"9_CR18","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.jnutbio.2014.12.007","volume":"26","author":"P-Y Chen","year":"2015","unstructured":"Chen P-Y, Wang J, Lin Y-C, Li C-C, Tsai C-W, Liu T-C, Chen H-W, Huang C-S, Lii C-K, Liu K-L (2015) 18-carbon polyunsaturated fatty acids ameliorate palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes. J Nutr Biochem 26:521\u2013531","journal-title":"J Nutr Biochem"},{"issue":"5 Suppl","key":"9_CR19","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1093\/ajcn\/35.5.1112","volume":"35","author":"JX Chipponi","year":"1982","unstructured":"Chipponi JX, Bleier JC, Santi MT, Rudman D (1982) Deficiencies of essential and conditionally essential nutrients. Am J Clin Nutr 35(5 Suppl):1112\u20131116","journal-title":"Am J Clin Nutr"},{"key":"9_CR20","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1136\/annrheumdis-2020-218810","volume":"80","author":"LN Coke","year":"2021","unstructured":"Coke LN, Wen H, Comeau M, Ghanem MH, Shih A, Metz CN et al (2021) Arg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus. Ann Rheumatic Dis 80:782\u2013787","journal-title":"Ann Rheumatic Dis"},{"issue":"2","key":"9_CR21","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1172\/JCI114476","volume":"85","author":"F Cominelli","year":"1990","unstructured":"Cominelli F, Nast CC, Llerena R, Dinarello CA, Zipser RD (1990) Interleukin 1 suppresses inflammation in rabbit colitis. Mediation by endogenous prostaglandins. J Clin Invest 85(2):582\u2013586","journal-title":"J Clin Invest"},{"issue":"3","key":"9_CR22","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1172\/JCI117060","volume":"93","author":"LJ Crafford","year":"1994","unstructured":"Crafford LJ, Wilder RL, Ristimaki AP et al (1994) Cyclooxygenase-1 and -2 expression in rheumatoid arthritis synovial tissues. J Clin Invest 93(3):1095\u20131101","journal-title":"J Clin Invest"},{"issue":"4","key":"9_CR23","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0006-2952(95)00156-T","volume":"50","author":"JD Croxtall","year":"1995","unstructured":"Croxtall JD, Choudhury Q, Tokumoto H, Flower RJ (1995) Lipocortin-1 and the control of arachidonic acid release in cell signalling. Glucocorticoids inhibit G protein-dependent activation of cPLA2 activity. Biochem Pharmacol 50(4):465\u2013474","journal-title":"Biochem Pharmacol"},{"key":"9_CR24","first-page":"1485","volume":"15","author":"UN Das","year":"1987","unstructured":"Das UN (1987) Biological significance of arachidonic acid. Med Sci Res 15:1485\u20131490","journal-title":"Med Sci Res"},{"key":"9_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/JIR.S9425","volume":"3","author":"UN Das","year":"2010","unstructured":"Das UN (2010) Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on molecular signatures of acute and chronic inflammation. J Inflamm Res 3:143\u2013170","journal-title":"J Inflamm Res"},{"issue":"2","key":"9_CR26","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/cc12574","volume":"17","author":"UN Das","year":"2013","unstructured":"Das UN (2013) n-3 fatty acids, \u03b3-linolenic acid, and antioxidants in sepsis. Crit Care. 17(2):312","journal-title":"Crit Care."},{"key":"9_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jare.2018.01.001","volume":"11","author":"UN Das","year":"2018","unstructured":"Das UN (2018) Arachidonic acid and other unsaturated fatty acids and some of their metabolites function as endogenous antimicrobial molecules: a review. J Adv Res. 11:57\u201366","journal-title":"J Adv Res."},{"key":"9_CR28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.nut.2019.02.016","volume":"65","author":"UN Das","year":"2019","unstructured":"Das UN (2019) Polyunsaturated fatty acids and sepsis. Nutrition 65:39\u201343","journal-title":"Nutrition"},{"key":"9_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0741-1","volume-title":"Molecular biochemical aspects of cancer","author":"UN Das","year":"2020","unstructured":"Das UN (2020) Molecular biochemical aspects of cancer. Humana Press, New York"},{"key":"9_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020241","volume":"11","author":"UN Das","year":"2021","unstructured":"Das UN (2021a) \u201cCell membrane theory of senescence\u201d and the role of bioactive lipids in aging and aging associated diseases and their therapeutic implications. Biomolecules 11:241","journal-title":"Biomolecules"},{"issue":"12","key":"9_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/biom11121873","volume":"11","author":"UN Das","year":"2021","unstructured":"Das UN (2021b) Essential fatty acids and their metabolites in the pathobiology of inflammation and its resolution. Biomolecules. 11(12):1873","journal-title":"Biomolecules."},{"key":"9_CR32","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41430-022-01173-8","volume":"77","author":"UN Das","year":"2022","unstructured":"Das UN (2022a) Pro- and anti-inflammatory bioactive lipids imbalance contributes to the pathobiology of autoimmune diseases. Eur J Clin Nutr 77:637\u2013651","journal-title":"Eur J Clin Nutr"},{"issue":"4","key":"9_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040749","volume":"14","author":"UN Das","year":"2022","unstructured":"Das UN (2022b) Arachidonic acid as Mechanotransducer of renin cell baroreceptor. Nutrients 14(4):749","journal-title":"Nutrients"},{"key":"9_CR34","volume-title":"Phospholipases","author":"UN Das","year":"2023","unstructured":"Das UN (2023a) Phospholipase A2 as a modulator of infection, inflammation, and immunity. In: Chakraborty S (ed) Phospholipases. Elsevier, New York"},{"key":"9_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/biom13091332","volume":"13","author":"UN Das","year":"2023","unstructured":"Das UN (2023b) Infection, inflammation, and immunity in sepsis. Biomolecules 13:1332","journal-title":"Biomolecules"},{"issue":"6","key":"9_CR36","doi-asserted-by":"publisher","first-page":"934","DOI":"10.3390\/medicina60060934","volume":"60","author":"UN Das","year":"2024","unstructured":"Das UN (2024) The dysregulation of essential fatty acid (EFA) metabolism may be a factor in the pathogenesis of sepsis. Medicina (Kaunas). 60(6):934","journal-title":"Medicina (Kaunas)."},{"key":"9_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2025.112924","volume":"141","author":"UN Das","year":"2026","unstructured":"Das UN (2026) Why vitamin C and corticosteroids are inadequate and how essential fatty acids (EFAs) can augment recovery from sepsis. Nutrition. 141:112924","journal-title":"Nutrition."},{"key":"9_CR38","unstructured":"Das UN (n.d.-a) Molecular basis of health and disease. Springer"},{"key":"9_CR39","unstructured":"Das UN (n.d.-b) Metabolic syndrome pathophysiology: the role of essential fatty acids. Wiley Blackwell,"},{"issue":"3","key":"9_CR40","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.plefa.2006.01.002","volume":"74","author":"UN Das","year":"2006","unstructured":"Das UN, Rao KP (2006) Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice. Prostaglandins Leukot Essent Fat Acids 74(3):165\u2013173","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"issue":"6","key":"9_CR41","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/0090-6980(85)90216-3","volume":"29","author":"UN Das","year":"1985","unstructured":"Das UN, Ramadevi G, Rao KP, Rao MS (1985) Prostaglandins and their precursors can modify genetic damage induced by gamma-radiation and benzo(a)pyrene. Prostaglandins 29(6):911\u2013920","journal-title":"Prostaglandins"},{"issue":"1","key":"9_CR42","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12944-025-02463-3","volume":"24","author":"UN Das","year":"2025","unstructured":"Das UN, Hacim\u00fcft\u00fcoglu A, Akpinar E, Gul M, Abd El-Aty AM (2025) Crosstalk between renin and arachidonic acid (and its metabolites). Lipids Health Dis 24(1):52","journal-title":"Lipids Health Dis"},{"key":"9_CR43","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1046\/j.1365-2567.2003.01749.x","volume":"110","author":"MMBW Dooper","year":"2003","unstructured":"Dooper MMBW, Van Riel B, Graus YMF, M\u2019Rabet L (2003) Dihomo-linolenic acid inhibits tumour necrosis factor production by human leucocytes independently of cyclooxygenase activity. Immunology 110:348\u2013357","journal-title":"Immunology"},{"key":"9_CR44","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1126\/science.aad9903","volume":"351","author":"R Duffin","year":"2016","unstructured":"Duffin R, O\u2019Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C et al (2016) Prostaglandin E 2 constrains systemic inflammation through an innate lymphoid cell\u2013IL-22 axis. Science 351:1333\u20131338","journal-title":"Science"},{"issue":"5","key":"9_CR45","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10787-014-0200-5","volume":"22","author":"RM El-Sayed","year":"2014","unstructured":"El-Sayed RM, Moustafa YM, El-Azab MF (2014) Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. Inflammopharmacology 22(5):305\u2013317","journal-title":"Inflammopharmacology"},{"issue":"8","key":"9_CR46","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1039\/D1FO03815J","volume":"13","author":"J Fang","year":"2022","unstructured":"Fang J, Zhang Z, Cheng Y, Yang H, Zhang H, Xue Z, Lu S, Dong Y, Song C, Zhang X, Zhou Y (2022) EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier. Food Funct. 13(8):4399\u20134420","journal-title":"Food Funct."},{"issue":"6","key":"9_CR47","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.4049\/jimmunol.174.6.3169","volume":"174","author":"JV Ferrante","year":"2005","unstructured":"Ferrante JV, Ferrante A (2005) Novel role of lipoxygenases in the inflammatory response: promotion of TNF mRNA decay by 15-hydroperoxyeicosatetraenoic acid in a monocytic cell line. J Immunol 174(6):3169\u20133172","journal-title":"J Immunol"},{"issue":"9","key":"9_CR48","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1016\/j.bbadis.2019.06.011","volume":"1865","author":"H Gallagher","year":"2019","unstructured":"Gallagher H, Williams JO, Ferekidis N, Ismail A, Chan YH, Michael DR, Guschina IA, Tyrrell VJ, O\u2019Donnell VB, Harwood JL, Khozin-Goldberg I, Boussiba S, Ramji DP (2019) Dihomo-\u03b3-linolenic acid inhibits several key cellular processes associated with atherosclerosis. Biochim Biophys Acta Mol basis Dis 1865(9):2538\u20132550","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"issue":"3","key":"9_CR49","doi-asserted-by":"publisher","first-page":"R121","DOI":"10.1186\/ar3851","volume":"14","author":"KR Gheorghe","year":"2012","unstructured":"Gheorghe KR, Sadique S, Leclerc P, Idborg H, Wobst I, Catrina AI, Jakobsson PJ, Korotkova M (2012) Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue. Arthritis Res Ther 14(3):R121","journal-title":"Arthritis Res Ther"},{"key":"9_CR50","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/9550","volume":"5","author":"D Gilroy","year":"1999","unstructured":"Gilroy D, Colvillenash PR, Willis DK, Chivers J, Paulclark MJ, Willoughby D (1999) Inducible cyclooxygenase may have anti-inflammatory properties. Nat Med 5:698\u2013701","journal-title":"Nat Med"},{"issue":"3","key":"9_CR51","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1096\/fj.03-0837com","volume":"18","author":"DW Gilroy","year":"2004","unstructured":"Gilroy DW, Newson J, Sawmynaden P, Willoughby DA, Croxtall JD (2004) A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation. FASEB J 18(3):489\u2013498","journal-title":"FASEB J"},{"key":"9_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075581","volume":"8","author":"T Gobbetti","year":"2013","unstructured":"Gobbetti T, Le Faouder P, Bertrand J, Dubourdeau M, Barocelli E, Cenac N, Vergnolle N (2013) Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusion in mouse intestine. PLoS One 8:e75581","journal-title":"PLoS One"},{"key":"9_CR53","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/bph.12957","volume":"172","author":"T Gobbetti","year":"2014","unstructured":"Gobbetti T, Ducheix S, Le Faouder P, Perez-Berezo T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M et al (2014) Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia\/reperfusion injury involve lipoxin A4and its receptor. Br J Pharmacol 172:910\u2013923","journal-title":"Br J Pharmacol"},{"issue":"4","key":"9_CR54","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.4049\/jimmunol.164.4.1663","volume":"164","author":"C Godson","year":"2000","unstructured":"Godson C, Mitchell S, Harvey K, Petasis NA, Hogg N, Brady HR (2000) Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. J Immunol 164(4):1663\u20131667","journal-title":"J Immunol"},{"key":"9_CR55","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/nu10101351","volume":"10","author":"M Gu","year":"2018","unstructured":"Gu M, Li Y, Tang H, Zhang C, Li W, Zhang Y, Li Y, Zhao Y, Song C (2018) Endogenous omega (n)-3 fatty acids in Fat-1 mice attenuated depression-like behavior, imbalance between microglial M1 and M2 phenotypes, and dysfunction of Neurotrophins induced by lipopolysaccharide administration. Nutrients 10:10. pii: E1351","journal-title":"Nutrients"},{"key":"9_CR56","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.nut.2019.05.007","volume":"66","author":"NKV Gundala","year":"2019","unstructured":"Gundala NKV, Das UN (2019) Arachidonic acid-rich ARASCO oil has anti-inflammatory and antidiabetic actions against streptozotocin + high fat diet induced diabetes mellitus in Wistar rats. Nutrition 66:203\u2013218","journal-title":"Nutrition"},{"key":"9_CR57","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.nut.2016.10.004","volume":"35","author":"NKV Gundala","year":"2017","unstructured":"Gundala NKV, Naidu VGM, Das UN (2017a) Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo. Nutrition 35:61\u201380","journal-title":"Nutrition"},{"issue":"2","key":"9_CR58","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/biof.1336","volume":"43","author":"NKV Gundala","year":"2017","unstructured":"Gundala NKV, Naidu VGM, Das UN (2017b) Arachidonic acid and lipoxin A4 attenuate alloxan-induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo. Biofactors 43(2):251\u2013271","journal-title":"Biofactors"},{"key":"9_CR59","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.nut.2016.10.004","volume":"35","author":"NKV Gundala","year":"2017","unstructured":"Gundala NKV, Naidu VGM, Das UN (2017c) Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5F cells in vitro and type 1 and type 2 diabetes mellitus in vivo. Nutrition 35:61\u201380","journal-title":"Nutrition"},{"key":"9_CR60","doi-asserted-by":"publisher","first-page":"E7768","DOI":"10.1073\/pnas.1806239115","volume":"115","author":"AL Hansen","year":"2018","unstructured":"Hansen AL et al (2018) Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling. Proc. Natl Acad. Sci. USA 115:E7768\u2013E7775","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"9_CR61","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1016\/j.jpedsurg.2010.08.044","volume":"45","author":"W Hao","year":"2010","unstructured":"Hao W, Wong OY, Liu X, Lee P, Chen Y, Wong KK (2010) N-3 fatty acids suppress inflammatory cytokine production by macrophages and hepatocytes. J Pediatr Surg 45:2412\u20132418","journal-title":"J Pediatr Surg"},{"key":"9_CR62","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/ni.1627","volume":"9","author":"O Haworth","year":"2008","unstructured":"Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD (2008a) Resolvin E1 regulates interleukin 23, interferon and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol 9:873\u2013879","journal-title":"Nat Immunol"},{"key":"9_CR63","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/ni.1627","volume":"9","author":"O Haworth","year":"2008","unstructured":"Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD (2008b) Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol 9:873\u2013879","journal-title":"Nat Immunol"},{"issue":"15","key":"9_CR64","doi-asserted-by":"publisher","first-page":"11290","DOI":"10.1016\/S0021-9258(18)82123-8","volume":"268","author":"M Hayakawa","year":"1993","unstructured":"Hayakawa M, Ishida N, Takeuchi K et al (1993) Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor. J Biol Chem 268(15):11290\u201311295","journal-title":"J Biol Chem"},{"key":"9_CR65","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.clnu.2025.09.006","volume":"54","author":"T He","year":"2025","unstructured":"He T, Zhang J, Zhao A, Luo S, Jiang H, Tang M, Zhang Y (2025) Docosahexaenoic acid supplementation in pregnancy and early lactation: impacts on breast milk docosahexaenoic acid and Maternal-Infant gut microbiota\u2014A randomized controlled trial. Clin Nutr. 54:71\u201382","journal-title":"Clin Nutr."},{"issue":"10","key":"9_CR66","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1073\/pnas.90.10.4475","volume":"90","author":"WG Hoeck","year":"1993","unstructured":"Hoeck WG, Ramesha CS, Chang DJ, Fan N, Heller RA (1993) Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the inducible synthesis. Proc Natl Acad Sci USA 90(10):4475\u20134479","journal-title":"Proc Natl Acad Sci USA"},{"key":"9_CR67","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/BF01986575","volume":"33","author":"L Iversen","year":"1991","unstructured":"Iversen L, Fogh K, Bojesen G et al (1991a) Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of anti-inflammatory compounds. Agents Actions 33:286\u2013291","journal-title":"Agents Actions"},{"issue":"3\u20134","key":"9_CR68","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/BF01986575","volume":"33","author":"L Iversen","year":"1991","unstructured":"Iversen L, Fogh K, Bojesen G, Kragballe K (1991b) Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of anti-inflammatory compounds. Agents Actions 33(3\u20134):286\u2013291","journal-title":"Agents Actions"},{"key":"9_CR69","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.molimm.2012.08.014","volume":"53","author":"KW Kalim","year":"2013","unstructured":"Kalim KW, Groettrup M (2013) Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. Mol Immunol 53:274\u2013282","journal-title":"Mol Immunol"},{"key":"9_CR70","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/s42003-021-02310-y","volume":"4","author":"T Kanno","year":"2021","unstructured":"Kanno T, Nakajima T, Yokoyama S, Asou HK, Sasamoto S, Kamii Y, Hayashizaki K, Ouchi Y, Onodera T, Takahashi Y et al (2021) SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells. Commun Biol 4:820","journal-title":"Commun Biol"},{"key":"9_CR71","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2174\/138920106779116874","volume":"7","author":"R Kapoor","year":"2006","unstructured":"Kapoor R (2006) Gamma Linolenic acid: an anti-inflammatory Omega-6 fatty acid. Curr Pharm Biotechnol 7:531\u2013534","journal-title":"Curr Pharm Biotechnol"},{"issue":"11","key":"9_CR72","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1097\/00003246-199311000-00025","volume":"21","author":"MD Karlstad","year":"1993","unstructured":"Karlstad MD, DeMichele SJ, Leathem WD, Peterson MB (1993) Effect of intravenous lipid emulsions enriched with gamma-linolenic acid on plasma n-6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats. Crit Care Med 21(11):1740\u20131749","journal-title":"Crit Care Med"},{"key":"9_CR73","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1136\/annrheumdis-2018-212988","volume":"77","author":"Y Kato","year":"2018","unstructured":"Kato Y, Park J, Takamatsu H, Konaka H, Aoki W, Aburaya S et al (2018) Apoptosis derived membrane vesicles drive the cGAS-STING pathway and enhance type I IFN production in systemic lupus erythematosus. Ann Rheumatic Dis 77:1507\u20131515","journal-title":"Ann Rheumatic Dis"},{"key":"9_CR74","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1007\/s13197-012-0677-0","volume":"51","author":"N Kaur","year":"2014","unstructured":"Kaur N, Chugh V, Gupta AK (2014) Essential fatty acids as functional components of foods- a review. J Food Sci Tech 51:2289\u20132303","journal-title":"J Food Sci Tech"},{"key":"9_CR75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194331","volume":"13","author":"JY Kim","year":"2018","unstructured":"Kim JY, Lim K, Kim KH, Kim JH, Choi JS, Shim SC (2018) N-3 polyunsaturated fatty acids restore Th17 and Treg balance in collagen antibody-induced arthritis. PLoS One 13:e0194331","journal-title":"PLoS One"},{"issue":"2","key":"9_CR76","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0899-9007(00)00468-8","volume":"17","author":"I Krishna Mohan","year":"2001","unstructured":"Krishna Mohan I, Das UN (2001) Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids. Nutrition 17(2):126\u2013151","journal-title":"Nutrition"},{"issue":"4","key":"9_CR77","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/BF00921008","volume":"2","author":"FA Kuehl Jr","year":"1977","unstructured":"Kuehl FA Jr, Humes JL, Beveridge GC, Van Arman CG, Egan RW (1977) Biologically active derivatives of fatty acids: prostaglandins, thromboxanes, and endoperoxides. Inflammation 2(4):285\u2013294","journal-title":"Inflammation"},{"issue":"1","key":"9_CR78","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1006\/cimm.1993.1134","volume":"149","author":"JE Kunicka","year":"1993","unstructured":"Kunicka JE, Talle MA, Denhardt GH, Brown M, Prince LA, Goldstein G (1993) Immunosuppression by glucocorticoids: inhibition of production of multiple lymphokines by in vivo administration of dexamethasone. Cell Immunol 149(1):39\u201349","journal-title":"Cell Immunol"},{"issue":"22","key":"9_CR79","doi-asserted-by":"publisher","first-page":"7802","DOI":"10.1128\/MCB.22.22.7802-7811.2002","volume":"22","author":"M Lasa","year":"2002","unstructured":"Lasa M, Abraham SM, Boucheron C, Saklatvala J, Clark AR (2002) Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol Cell Biol 22(22):7802\u20137811","journal-title":"Mol Cell Biol"},{"issue":"Pt 1","key":"9_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.117211","volume":"221","author":"X Li","year":"2025","unstructured":"Li X, Jing B, Xia C, Wang X, Qiao X, Zhang T, Li H, Che H (2025) Nontargeted metabolomics combining with intestinal microbiota revealed the potential mechanisms of DHA\/EPA\u2014acetylated astaxanthin esters in regulating the abnormal lipid metabolism. Food Res Int. 221(Pt 1):117211","journal-title":"Food Res Int."},{"key":"9_CR81","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1254915","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y, Pu F (2023) Updated roles of cGAS-STING signaling in autoimmune diseases. Front Immunol 14:1254915","journal-title":"Front Immunol"},{"key":"9_CR82","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba2894","volume":"370","author":"AJ Lomakin","year":"2020","unstructured":"Lomakin AJ, Cattin CJ, Cuvelier D, Alraies Z, Molina M, Nader GPF, Srivastava N, S\u00e1ez PJ, Garcia-Arcos JM, Zhitnyak IY et al (2020) The nucleus acts as a ruler tailoring cell responses to spatial constraints. Science 370:eaba2894","journal-title":"Science"},{"key":"9_CR83","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aar8320","volume":"4","author":"CA Loynes","year":"2018","unstructured":"Loynes CA, Lee JA, Robertson AL, Steel MJ, Ellett F, Feng Y, Levy BD, Whyte MK, Renshaw SA (2018) PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Sci Adv 4:eaar8320","journal-title":"Sci Adv"},{"key":"9_CR84","doi-asserted-by":"publisher","first-page":"1423576","DOI":"10.3389\/fnut.2024.1423576","volume":"11","author":"D Lu","year":"2024","unstructured":"Lu D, Yao D, Hu G, Zhou J, Shen X, Qian L (2024) Maternal docosahexaenoic acid supplementation during lactation improves exercise performance, enhances intestinal glucose absorption and modulates gut microbiota in weaning offspring mice. Front Nutr. 11:1423576","journal-title":"Front Nutr."},{"key":"9_CR85","doi-asserted-by":"publisher","first-page":"8272","DOI":"10.1038\/ncomms9272","volume":"6","author":"T Maekawa","year":"2015","unstructured":"Maekawa T, Hosur K, Abe T, Kantarci A, Ziogas A, Wang B, Van Dyke TE, Chavakis T, Hajishengallis G (2015) Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3\u03b2-C\/EBP\u03b2 pathway. Nat Commun 6:8272","journal-title":"Nat Commun"},{"issue":"4B","key":"9_CR86","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0002-9343(86)90073-2","volume":"80","author":"CL Malmsten","year":"1986","unstructured":"Malmsten CL (1986) Prostaglandins, thromboxanes, and leukotrienes in inflammation. Am J Med 80(4B):11\u201317","journal-title":"Am J Med"},{"issue":"1","key":"9_CR87","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/1523-1747.ep12515911","volume":"96","author":"CC Miller","year":"1991","unstructured":"Miller CC, Tang W, Ziboh VA, Fletcher MP (1991) Dietary supplementation with ethyl ester concentrates of fish oil (n-3) and borage oil (n-6) polyunsaturated fatty acids induces epidermal generation of local putative anti-inflammatory metabolites. J Invest Dermatol 96(1):98\u2013103","journal-title":"J Invest Dermatol"},{"key":"9_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122141","volume":"333","author":"A Mitra","year":"2023","unstructured":"Mitra A, Shanavas S, Chaudhury D, Bose B, Das UN, Shenoy PS (2023) Mitigation of chronic glucotoxicity-mediated skeletal muscle atrophy by arachidonic acid. Life Sci 333:122141","journal-title":"Life Sci"},{"issue":"1","key":"9_CR89","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jep.2013.10.012","volume":"151","author":"S Montserrat-de la Paz","year":"2014","unstructured":"Montserrat-de la Paz S, Garc\u00eda-Gim\u00e9nez MD, \u00c1ngel-Mart\u00edn M, P\u00e9rez-Camino MC, Fern\u00e1ndez Arche A (2014) Long-chain fatty alcohols from evening primrose oil inhibit the inflammatory response in murine peritoneal macrophages. J Ethnopharmacol 151(1):131\u2013136","journal-title":"J Ethnopharmacol"},{"key":"9_CR90","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94463","volume":"3","author":"MP Motwani","year":"2018","unstructured":"Motwani MP, Colas RA, George MJ, Flint JD, Dalli J, Richard-Loendt A, De Maeyer R, Serhan CN, Gilroy DW (2018) Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli\u2013driven acute inflammation. JCI Insight 3:94463","journal-title":"JCI Insight"},{"key":"9_CR91","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.605930","volume":"12","author":"M Motwani","year":"2021","unstructured":"Motwani M, McGowan J, Antonovitch J, Gao KM, Jiang Z, Sharma S et al (2021) cGAS-STING pathway does not promote autoimmunity in murine models of SLE. Front Immunol 12:605930","journal-title":"Front Immunol"},{"issue":"1","key":"9_CR92","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1210\/edrv-5-1-25","volume":"5","author":"A Munck","year":"1984","unstructured":"Munck A, Guyre PM, Holbrook NJ (1984) Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 5(1):25\u201344","journal-title":"Endocr Rev"},{"issue":"3","key":"9_CR93","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032116","volume":"24","author":"AM Mustonen","year":"2023","unstructured":"Mustonen AM, Nieminen P (2023) Dihomo-\u03b3-Linolenic acid (20,3n-6)-metabolism, derivatives, and potential significance in chronic inflammation. Int J Mol Sci 24(3):2116","journal-title":"Int J Mol Sci"},{"key":"9_CR94","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/B978-0-12-387663-8.00004-1","volume":"110","author":"S Nagata","year":"2011","unstructured":"Nagata S, Kawane K (2011) Autoinflammation by endogenous DNA. Adv Immunol 110:139\u2013161","journal-title":"Adv Immunol"},{"key":"9_CR95","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2023.108438","volume":"120","author":"M Nihad","year":"2023","unstructured":"Nihad M, Sen U, Chaudhury D, Das UN, Shenoy PS, Bose B (2023) Arachidonic acid modulates the cellular energetics of human pluripotent stem cells and protects the embryoid bodies from embryotoxicity effects in vitro. Reprod Toxicol 120:108438","journal-title":"Reprod Toxicol"},{"key":"9_CR96","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.nutres.2019.10.004","volume":"72","author":"F Novak","year":"2019","unstructured":"Novak F, Vecka M, Meisnerova E, Sevela S, Vavrova L, Rychlikova J, Dolezalova L, Myslivcova D, Zak A, Vitek L et al (2019) Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in home parenteral nutrition patients: a crossover study. Nutr Res 72:70\u201379","journal-title":"Nutr Res"},{"issue":"6528","key":"9_CR97","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8059","volume":"371","author":"AR Palla","year":"2021","unstructured":"Palla AR, Ravichandran M, Wang YX, Alexandrova L, Yang AV, Kraft P, Holbrook CA, Sch\u00fcrch CM, Ho ATV, Blau HM (2021) Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. Science. 371(6528):eabc8059. https:\/\/doi.org\/10.1126\/science.abc8059. Epub 2020 Dec 10. PMID: 33303683; PMCID: PMC7938328","journal-title":"Science."},{"issue":"Pt 1","key":"9_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133725","volume":"276","author":"Z Pan","year":"2024","unstructured":"Pan Z, Luo H, He F, Du Y, Wang J, Zeng H, Xu Z, Sun Y, Li M (2024) Guava polysaccharides attenuate high fat and STZ-induced hyperglycemia by regulating gut microbiota and arachidonic acid metabolism. Int J Biol Macromol. 276(Pt 1):133725","journal-title":"Int J Biol Macromol."},{"key":"9_CR99","doi-asserted-by":"publisher","unstructured":"Patel MN, Tiwari S, Wang Y et al (2025) Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids. Nat Biotechnol. https:\/\/doi.org\/10.1038\/s41587-025-02556-5","DOI":"10.1038\/s41587-025-02556-5"},{"key":"9_CR100","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ejphar.2015.08.049","volume":"785","author":"R Poorani","year":"2016","unstructured":"Poorani R, Bhatt AN, Dwarakanath B, Das UN (2016) COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance. Eur J Pharmacol 785:116\u2013132","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"9_CR101","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.5114\/aoms.2020.92469","volume":"16","author":"R Poorani","year":"2020","unstructured":"Poorani R, Bhatt AN, Das UN (2020) Modulation of pro-inflammatory and pro-resolution mediators by \u03b3-linolenic acid: an important element in radioprotection against ionizing radiation. Arch Med Sci 16(6):1448\u20131456","journal-title":"Arch Med Sci"},{"issue":"1","key":"9_CR102","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0952-3278(91)90068-G","volume":"42","author":"PS Prabha","year":"1991","unstructured":"Prabha PS, Das UN, Ramesh G, Kumar KV, Kamalakar V (1991) Free radical generation, lipid peroxidation and essential fatty acids in patients with septicemia. Prostaglandins Leukot Essent Fatty Acids 42(1):61\u201365","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"9_CR103","doi-asserted-by":"publisher","first-page":"5894","DOI":"10.4049\/jimmunol.1203141","volume":"190","author":"X Qian","year":"2013","unstructured":"Qian X, Gu L, Ning H, Zhang Y, Hsueh EC, Fu M, Hu X, Wei L, Hoft DF, Liu J (2013) Increased Th17 cells in the tumor microenvironment is mediated by IL-23 via tumor-secreted prostaglandin E2. J Immunol 190:5894\u20135902","journal-title":"J Immunol"},{"issue":"24","key":"9_CR104","doi-asserted-by":"publisher","first-page":"10043","DOI":"10.1073\/pnas.87.24.10043","volume":"87","author":"MW Radomski","year":"1990","unstructured":"Radomski MW, Palmer RM, Moncada S (1990) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87(24):10043\u201310047","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"9_CR105","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060797","volume":"12","author":"P Rengachar","year":"2022","unstructured":"Rengachar P, Bhatt AN, Polavarapu S, Veeramani S, Krishnan A, Sadananda M, Das UN (2022) Gamma-Linolenic acid (GLA) protects against ionizing radiation-induced damage: an in vitro and in vivo study. Biomolecules 12(6):797","journal-title":"Biomolecules"},{"key":"9_CR106","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1038\/s41598-018-23623-9","volume":"8","author":"N Saito-Sasaki","year":"2018","unstructured":"Saito-Sasaki N, Sawada Y, Mashima E, Yamaguchi T, Ohmori S, Yoshioka H, Haruyama S, Okada E, Nakamura M (2018) Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression. Sci Rep 8:5522","journal-title":"Sci Rep"},{"issue":"5","key":"9_CR107","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1172\/JCI117185","volume":"93","author":"D Salvemini","year":"1994","unstructured":"Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, Needleman P (1994) Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest 93(5):1940\u20131947","journal-title":"J Clin Invest"},{"key":"9_CR108","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00011-018-1153-8","volume":"67","author":"JS Samuels","year":"2018","unstructured":"Samuels JS, Holland L, L\u00f3pez M, Meyers K, Cumbie WG, McClain A, Ignatowicz A, Nelson D, Shashidharamurthy R (2018) Prostaglandin E2 and IL-23 interconnects STAT3 and RoR\u03b3 pathways to initiate Th17 CD4+ T-cell development during rheumatoid arthritis. Inflamm Res 67:589\u2013596","journal-title":"Inflamm Res"},{"issue":"Suppl 1","key":"9_CR109","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2165\/00003495-198700331-00003","volume":"33","author":"B Samuelsson","year":"1987","unstructured":"Samuelsson B (1987) An elucidation of the arachidonic acid cascade. Discovery of prostaglandins, thromboxane and leukotrienes. Drugs 33(Suppl 1):2\u20139","journal-title":"Drugs"},{"key":"9_CR110","doi-asserted-by":"publisher","first-page":"11873","DOI":"10.1038\/s41598-018-30373-1","volume":"8","author":"Y Sawada","year":"2018","unstructured":"Sawada Y, Honda T, Nakamizo S, Otsuka A, Ogawa N, Kobayashi Y, Nakamura M, Kabashima K (2018) Resolvin E1 attenuates murine psoriatic dermatitis. Sci Rep 8:11873. https:\/\/doi.org\/10.1038\/s41598-018-30373-1","journal-title":"Sci Rep"},{"issue":"12","key":"9_CR111","doi-asserted-by":"publisher","first-page":"4436","DOI":"10.1128\/iai.59.12.4436-4442.1991","volume":"59","author":"JH Schwab","year":"1991","unstructured":"Schwab JH, Anderle SK, Brown RR, Dalldorf FG, Thompson RC (1991) Pro- and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall-induced arthritis in rats. Infect Immun 59(12):4436\u20134442","journal-title":"Infect Immun"},{"issue":"8","key":"9_CR112","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1084\/jem.192.8.1197","volume":"192","author":"CN Serhan","year":"2000","unstructured":"Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K (2000) Novel functional sets of lipid-derived mediators with anti-inflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal anti-inflammatory drugs and transcellular processing. J Exp Med 192(8):1197\u20131204","journal-title":"J Exp Med"},{"key":"9_CR113","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1084\/jem.20020760","volume":"196","author":"CN Serhan","year":"2002","unstructured":"Serhan CN, Hong S, Gronert K et al (2002) Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 196:1025\u20131037","journal-title":"J Exp Med"},{"key":"9_CR114","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1096\/fj.03-1367fje","volume":"18","author":"AF Sheibanie","year":"2004","unstructured":"Sheibanie AF, Tadmori I, Jing H, Vassiliou E, Ganea D (2004) Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J 18:1318\u20131320","journal-title":"FASEB J"},{"key":"9_CR115","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.890277","volume":"9","author":"J Shen","year":"2022","unstructured":"Shen J, Zhang L, Wang Y, Chen Z, Ma J, Fang X, Das UN, Yao K (2022) Beneficial actions of essential fatty acids in Streptozotocin-induced type 1 diabetes mellitus. Front Nutr 9:890277","journal-title":"Front Nutr"},{"key":"9_CR116","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/984690","volume":"2015","author":"Q Shi","year":"2015","unstructured":"Shi Q, Yin Z, Zhao B, Sun F, Yu H, Yin X, Zhang L, Wang S (2015) PGE2 elevates IL-23 production in human dendritic cells via a cAMP dependent pathway. Mediat Inflamm 2015:984690","journal-title":"Mediat Inflamm"},{"issue":"25","key":"9_CR117","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1161\/01.CIR.97.25.2580","volume":"97","author":"E Siguel","year":"1998","unstructured":"Siguel E (1998) Diagnosing essential fatty acid deficiency. Circulation 97(25):2580\u20132583","journal-title":"Circulation"},{"issue":"1","key":"9_CR118","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1054\/plef.2000.0236","volume":"64","author":"Y Suresh","year":"2001","unstructured":"Suresh Y, Das UN (2001) Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. Prostaglandins Leukot Essent Fat Acids 64(1):37\u201352","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"issue":"2","key":"9_CR119","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0899-9007(02)00856-0","volume":"19","author":"Y Suresh","year":"2003","unstructured":"Suresh Y, Das UN (2003) Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus: effect of omega-6 fatty acids. Nutrition 19(2):93\u2013114","journal-title":"Nutrition"},{"key":"9_CR120","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0952-3278(91)90068-G","volume":"42","author":"P Suryaprabha","year":"1991","unstructured":"Suryaprabha P, Das UN, Ramesh G, Kumar KV, Kamalakar V (1991) Free radicals, lipid peroxidation and essential fatty acids in patients with septicemia. Prostaglandins Leukot Essen Fat Acids 42:61\u201365","journal-title":"Prostaglandins Leukot Essen Fat Acids"},{"issue":"1\u20133","key":"9_CR121","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0090-6980(99)00033-7","volume":"60","author":"T Takano","year":"2000","unstructured":"Takano T, Panesar M, Papillon J, Cybulsky AV (2000) Cyclooxygenases-1 and 2 couple to cytosolic but not group IIA phospholipase A2 in COS-1 cells. Prostaglandins Other Lipid Mediat 60(1\u20133):15\u201326","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"9_CR122","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-13-30","volume":"13","author":"N Tateishi","year":"2014","unstructured":"Tateishi N, Kakutani S, Kawashima H et al (2014) Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin A4 contents in colon, but does not affect severity or prostaglandin E2 content in murine colitis model. Lipids Health Dis 13:30","journal-title":"Lipids Health Dis"},{"key":"9_CR123","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-14-3","volume":"14","author":"N Tateishi","year":"2015","unstructured":"Tateishi N, Kaneda Y, Kakutani S et al (2015) Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model. Lipids Health Dis 14:3","journal-title":"Lipids Health Dis"},{"key":"9_CR124","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2020.106505","volume":"152","author":"JM Thornton","year":"2021","unstructured":"Thornton JM, Walker JM, Sundarasivarao PYK, Spur BW, Rodriguez A, Yin K (2021) Lipoxin A4 promotes reduction and antibiotic efficacy against Pseudomonas aeruginosa biofilm. Prostaglandins Other Lipid Mediat. 152:106505","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"4","key":"9_CR125","doi-asserted-by":"publisher","first-page":"e288","DOI":"10.1097\/CCM.0000000000000162","volume":"42","author":"T Ueda","year":"2014","unstructured":"Ueda T, Fukunaga K, Seki H, Miyata J, Arita M, Miyasho T, Obata T, Asano K, Betsuyaku T, Takeda J (2014) Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis*. Crit Care Med. 42(4):e288\u2013e295","journal-title":"Crit Care Med."},{"key":"9_CR126","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.jaci.2018.01.054","volume":"142","author":"Y Ueharaguchi","year":"2018","unstructured":"Ueharaguchi Y, Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainichi T, Egawa G, Nakashima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi Y, Kabashima K (2018) Thromboxane A2 facilitates IL-17A production from V\u03b34+ \u03b3\u03b4 T cells and promotes psoriatic dermatitis in mice. J Allergy Clin Immunol 142:680\u2013683","journal-title":"J Allergy Clin Immunol"},{"key":"9_CR127","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba2644","volume":"370","author":"V Venturini","year":"2020","unstructured":"Venturini V, Pezzano F, Castro FC, H\u00e4kkinen H-M, Jim\u00e9nez-Delgado S, Colomer-Rosell M, Marro M, Tolosa-Ramon Q, Paz-L\u00f3pez S, Valverde MA et al (2020) The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior. Science 370:eaba2644","journal-title":"Science"},{"issue":"4","key":"9_CR128","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040325","volume":"9","author":"M Veselinovic","year":"2017","unstructured":"Veselinovic M, Vasiljevic D, Vucic V, Arsic A, Petrovic S, Tomic-Lucic A, Savic M, Zivanovic S, Stojic V, Jakovljevic V (2017) Clinical benefits of n-3 PUFA and \u0264-Linolenic acid in patients with rheumatoid arthritis. Nutrients 9(4):325","journal-title":"Nutrients"},{"key":"9_CR129","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cmet.2021.12.007","volume":"34","author":"IK Vila","year":"2022","unstructured":"Vila IK, Chamma H, Steer A, Saccas M, Taffoni C, Turtoi E, Reinert LS, Hussain S, Marines J, Jin L et al (2022) STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. Cell Metab 34:125\u2013139","journal-title":"Cell Metab"},{"issue":"10","key":"9_CR130","doi-asserted-by":"publisher","first-page":"5120","DOI":"10.4049\/jimmunol.164.10.5120","volume":"164","author":"I Walev","year":"2000","unstructured":"Walev I, Klein J, Husmann M et al (2000) Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2. J Immunol 164(10):5120\u20135124","journal-title":"J Immunol"},{"key":"9_CR131","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1167\/iovs.18-24562","volume":"59","author":"H Wang","year":"2018","unstructured":"Wang H, Zhao Q, Luo D, Yin Y, Li T, Zhao M (2018) Resolvin E1 inhibits corneal allograft rejection in high-risk corneal transplantation. Invest Ophthalmol Vis Sci 59:3911\u20133919","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"20","key":"9_CR132","doi-asserted-by":"publisher","first-page":"8697","DOI":"10.1007\/s00253-014-5949-3","volume":"98","author":"N Watanabe","year":"2014","unstructured":"Watanabe N, Masubuchi D, Itoh M, Teradu S, Yazawa H, Uemura H (2014) Oral administration of whole dihomo-\u03b3-linolenic acid-producing Saccharomyces cerevisiae suppresses cutaneous inflammatory responses induced by croton oil application in mice. Appl Microbiol Biotechnol 98(20):8697\u20138706","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"9_CR133","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1080\/09168451.2019.1667220","volume":"84","author":"N Watanabe","year":"2020","unstructured":"Watanabe N, Teradu S, Ohtani M, Uemura H (2020) Oral administration of whole dihomo-\u03b3-linolenic acid-producing yeast suppresses allergic contact dermatitis in mice. Biosci Biotechnol Biochem 84(1):208\u2013215","journal-title":"Biosci Biotechnol Biochem"},{"issue":"8","key":"9_CR134","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.1073\/pnas.92.8.3473","volume":"92","author":"C-C Wu","year":"1995","unstructured":"Wu C-C, Croxtall JD, Perretti M et al (1995) Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc Natl Acad Sci USA 92(8):3473\u20133477","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"9_CR135","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1523-1755.2005.00379.x","volume":"68","author":"SH Wu","year":"2005","unstructured":"Wu SH, Lu C, Dong L, Zhou GP, He ZG, Chen ZQ (2005) Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells. Kidney Int 68(1):35\u201346","journal-title":"Kidney Int"},{"issue":"15","key":"9_CR136","doi-asserted-by":"publisher","DOI":"10.3390\/nu15153465","volume":"15","author":"K Yokoi","year":"2023","unstructured":"Yokoi K, Yanagimoto K, Hayamizu K (2023) Supplementation of Dihomo-\u03b3-Linolenic acid for pollen-induced allergic symptoms in healthy subjects: a randomized, double-blinded, placebo-controlled trial. Nutrients 15(15):3465","journal-title":"Nutrients"},{"issue":"3","key":"9_CR137","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.arcmed.2014.03.008","volume":"45","author":"HN Yu","year":"2014","unstructured":"Yu HN, Zhu J, Pan WS, Shen SR, Shan WG, Das UN (2014) Effects of fish oil with a high content of n-3 polyunsaturated fatty acids on mouse gut microbiota. Arch Med Res. 45(3):195\u2013202","journal-title":"Arch Med Res."},{"issue":"1","key":"9_CR138","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1183\/09031936.03.00004402","volume":"22","author":"M Zaitsu","year":"2003","unstructured":"Zaitsu M, Hamasaki Y, Tsuji K et al (2003) Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells. Eur Respir J 22(1):35\u201342","journal-title":"Eur Respir J"},{"issue":"6240","key":"9_CR139","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2340","volume":"348","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD (2015) TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 348(6240):aaa2340. https:\/\/doi.org\/10.1126\/science.aaa2340. PMID: 26068857; PMCID: PMC4481126","journal-title":"Science"},{"issue":"10","key":"9_CR140","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900946","volume":"64","author":"P Zhuang","year":"2020","unstructured":"Zhuang P, Zhang Y, Shou Q, Li H, Zhu Y, He L, Chen J, Jiao J (2020) Eicosapentaenoic and Docosahexaenoic Acids Differentially Alter Gut Microbiome and Reverse High-Fat Diet-Induced Insulin Resistance. Mol Nutr Food Res. 64(10):e1900946","journal-title":"Mol Nutr Food Res."},{"issue":"1","key":"9_CR141","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s40168-021-01126-6","volume":"9","author":"P Zhuang","year":"2021","unstructured":"Zhuang P, Li H, Jia W, Shou Q, Zhu Y, Mao L, Wang W, Wu F, Chen X, Wan X, Wu Y, Liu X, Li Y, Zhu F, He L, Chen J, Zhang Y, Jiao J (2021) Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db\/db mice. Microbiome. 9(1):185","journal-title":"Microbiome."}],"container-title":["Reviews of Physiology, Biochemistry and Pharmacology","Physiology, Pharmacology and Clinical Significance of Arachidonic Acid"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-92-5964-9_9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:12:28Z","timestamp":1791238348000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-981-92-5964-9_9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"ISBN":["9789819259632","9789819259649"],"references-count":141,"URL":"https:\/\/doi.org\/10.1007\/978-981-92-5964-9_9","relation":{},"ISSN":["0303-4240","1617-5786"],"issn-type":[{"value":"0303-4240","type":"print"},{"value":"1617-5786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"6 October 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}