{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:44:44Z","timestamp":1764701084042,"version":"3.40.3"},"publisher-location":"Singapore","reference-count":37,"publisher":"Springer Nature Singapore","isbn-type":[{"type":"print","value":"9789819982950"},{"type":"electronic","value":"9789819982967"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1007\/978-981-99-8296-7_27","type":"book-chapter","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:04:14Z","timestamp":1700179454000},"page":"381-389","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Digital Therapeutics System for\u00a0the\u00a0Diagnosis and\u00a0Management of\u00a0Depression: Work in\u00a0Progress"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-6104","authenticated-orcid":false,"given":"Yongho","family":"Lee","sequence":"first","affiliation":[]},{"given":"Vinh","family":"Pham","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8796-6316","authenticated-orcid":false,"given":"Jieming","family":"Zhang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-8114","authenticated-orcid":false,"given":"Tai-Myoung","family":"Chung","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"27_CR1","unstructured":"What is Depression? https:\/\/www.psychiatry.org:443\/patients-families\/depression\/what-is-depression"},{"key":"27_CR2","unstructured":"Depressive disorder (depression). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression"},{"key":"27_CR3","unstructured":"GBD Results. https:\/\/vizhub.healthdata.org\/gbd-results"},{"key":"27_CR4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jad.2013.01.004","volume":"147","author":"K Hawton","year":"2013","unstructured":"Hawton, K., Casa\u00f1as i Comabella, C., Haw, C., Saunders, K.: Risk factors for suicide in individuals with depression: a systematic review. J. Affect. Disord. 147, 17\u201328 (2013)","journal-title":"J. Affect. Disord."},{"key":"27_CR5","unstructured":"DTA: Digital Therapeutics Industry Report 2018 (2018). https:\/\/dtxalliance.org\/2018\/10\/23\/dtaindustryreport2018\/"},{"key":"27_CR6","first-page":"5400","volume":"62","author":"N Sartorius","year":"2001","unstructured":"Sartorius, N.: The economic and social burden of depression. J. Clin. Psychiatry 62, 5400 (2001)","journal-title":"J. Clin. Psychiatry"},{"key":"27_CR7","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","volume":"398","author":"DF Santomauro","year":"2021","unstructured":"Santomauro, D.F., et al.: Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet 398, 1700\u20131712 (2021)","journal-title":"Lancet"},{"key":"27_CR8","doi-asserted-by":"publisher","first-page":"603","DOI":"10.2147\/NDT.S128584","volume":"15","author":"RK Bailey","year":"2019","unstructured":"Bailey, R.K., Mokonogho, J., Kumar, A.: Racial and ethnic differences in depression: current perspectives. Neuropsychiatr. Dis. Treat. 15, 603\u2013609 (2019)","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"27_CR9","unstructured":"Depression. https:\/\/www.nimh.nih.gov\/health\/publications\/depression"},{"key":"27_CR10","unstructured":"Kroenke, K., Spitzer, R.L., Williams, J.B.W.: Patient health questionnaire-9 (2011)"},{"key":"27_CR11","unstructured":"Beck Depression Inventory-II. https:\/\/psycnet.apa.org\/doiLanding?doi=10.1037%2Ft00742-000"},{"key":"27_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00787-019-01469-4","volume":"30","author":"J Radez","year":"2021","unstructured":"Radez, J., Reardon, T., Creswell, C., Lawrence, P.J., Evdoka-Burton, G., Waite, P.: Why do children and adolescents (not) seek and access professional help for their mental health problems? A systematic review of quantitative and qualitative studies. Eur. Child Adolesc. Psychiatry 30, 183\u2013211 (2021)","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"27_CR13","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.4103\/jfmpc.jfmpc_105_20","volume":"9","author":"A Dang","year":"2020","unstructured":"Dang, A., Arora, D., Rane, P.: Role of digital therapeutics and the changing future of healthcare. J. Family Med. Primary Care 9, 2207 (2020)","journal-title":"J. Family Med. Primary Care"},{"key":"27_CR14","doi-asserted-by":"crossref","unstructured":"Sundar, S.S., Kim, J.: Machine heuristic: when we trust computers more than humans with our personal information. In: Proceedings of the 2019 CHI Conference on Human Factors in Computing Systems, CHI 2019, New York, NY, USA, pp. 1\u20139. Association for Computing Machinery (2019)","DOI":"10.1145\/3290605.3300768"},{"key":"27_CR15","doi-asserted-by":"publisher","first-page":"106319","DOI":"10.1016\/j.cmpb.2021.106319","volume":"209","author":"JS Hong","year":"2021","unstructured":"Hong, J.S., Wasden, C., Han, D.H.: Introduction of digital therapeutics. Comput. Methods Program. Biomed. 209, 106319 (2021)","journal-title":"Comput. Methods Program. Biomed."},{"key":"27_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41746-023-00777-z","volume":"6","author":"C Wang","year":"2023","unstructured":"Wang, C., Lee, C., Shin, H.: Digital therapeutics from bench to bedside. NPJ Digit. Med. 6, 1\u201310 (2023)","journal-title":"NPJ Digit. Med."},{"key":"27_CR17","doi-asserted-by":"publisher","first-page":"265","DOI":"10.4070\/kcj.2022.0014","volume":"52","author":"JH Ju","year":"2022","unstructured":"Ju, J.H., Sim, B., Lee, J., Lee, J.Y.: Reimbursement of digital therapeutics: future perspectives in Korea. Korean Circul. J. 52, 265\u2013279 (2022)","journal-title":"Korean Circul. J."},{"key":"27_CR18","doi-asserted-by":"publisher","first-page":"e857","DOI":"10.2196\/jmir.4.1.e3","volume":"4","author":"H Christensen","year":"2002","unstructured":"Christensen, H., Griffiths, K.M., Korten, A.: Web-based cognitive behavior therapy: analysis of site usage and changes in depression and anxiety scores. J. Med. Internet Res. 4, e857 (2002)","journal-title":"J. Med. Internet Res."},{"key":"27_CR19","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.2196\/jmir.6.4.e46","volume":"6","author":"H Christensen","year":"2004","unstructured":"Christensen, H., Griffiths, K.M., Korten, A.E., Brittliffe, K., Groves, C.: A comparison of changes in anxiety and depression symptoms of spontaneous users and trial participants of a cognitive behavior therapy website. J. Med. Internet Res. 6, e124 (2004)","journal-title":"J. Med. Internet Res."},{"key":"27_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/j.1440-1614.2006.01743.x","volume":"40","author":"H Christensen","year":"2006","unstructured":"Christensen, H., Griffiths, K., Groves, C., Korten, A.: Free Range users and one hit wonders: community users of an internet-based cognitive behaviour therapy program. Aust. N. Z. J. Psychiatry 40, 59\u201362 (2006)","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"27_CR21","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1136\/bmj.297.6653.897","volume":"297","author":"D Goldberg","year":"1988","unstructured":"Goldberg, D., Bridges, K., Duncan-Jones, P., Grayson, D.: Detecting anxiety and depression in general medical settings. BMJ 297, 897\u2013899 (1988)","journal-title":"BMJ"},{"key":"27_CR22","unstructured":"Lara, M.A., Tiburcio, M., Aguilar Abrego, A., S\u00e1nchez-Sol\u00eds, A.: A four-year experience with a Web-based self-help intervention for depressive symptoms in Mexico. Rev. Panamericana Salud Publica = Pan Am. J. Public Health 35(5\u20136), 399\u2013406 (2014)"},{"key":"27_CR23","unstructured":"The CES-D Scale: A Self-Report Depression Scale for Research in the General Population - Lenore Sawyer Radloff (1977). https:\/\/journals.sagepub.com\/doi\/10.1177\/014662167700100306"},{"key":"27_CR24","doi-asserted-by":"publisher","first-page":"e9775","DOI":"10.2196\/jmir.9775","volume":"20","author":"J Zulueta","year":"2018","unstructured":"Zulueta, J., et al.: Predicting mood disturbance severity with mobile phone keystroke metadata: a BiAffect digital phenotyping study. J. Med. Internet Res. 20, e9775 (2018)","journal-title":"J. Med. Internet Res."},{"key":"27_CR25","doi-asserted-by":"crossref","unstructured":"Long, Y., Lin, Y., Zhang, Z., Jiang, R., Wang, Z.: Objective assessment of depression using multiple physiological signals. In: 2021 14th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI), pp. 1\u20136 (2021)","DOI":"10.1109\/CISP-BMEI53629.2021.9624394"},{"key":"27_CR26","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1109\/TBME.2020.3025908","volume":"68","author":"S Kontaxis","year":"2021","unstructured":"Kontaxis, S., et al.: Photoplethysmographic waveform analysis for autonomic reactivity assessment in depression. IEEE Trans. Biomed. Eng. 68, 1273\u20131281 (2021)","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"27_CR27","doi-asserted-by":"publisher","first-page":"625247","DOI":"10.3389\/fpsyt.2021.625247","volume":"12","author":"I Moshe","year":"2021","unstructured":"Moshe, I., et al.: Predicting symptoms of depression and anxiety using smartphone and wearable data. Front. Psychiatry 12, 625247 (2021)","journal-title":"Front. Psychiatry"},{"key":"27_CR28","doi-asserted-by":"publisher","DOI":"10.2196\/mhealth.5284","volume":"4","author":"PGF Cheng","year":"2016","unstructured":"Cheng, P.G.F., et al.: Psychologist in a pocket: lexicon development and content validation of a mobile-based app for depression screening. JMIR Mhealth Uhealth 4, e5284 (2016)","journal-title":"JMIR Mhealth Uhealth"},{"key":"27_CR29","doi-asserted-by":"crossref","unstructured":"Joshi, J., Goecke, R., Parker, G., Breakspear, M.: Can body expressions contribute to automatic depression analysis? In: 2013 10th IEEE International Conference and Workshops on Automatic Face and Gesture Recognition (FG), pp. 1\u20137 (2013)","DOI":"10.1109\/FG.2013.6553796"},{"key":"27_CR30","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41597-022-01262-0","volume":"9","author":"S Saganowski","year":"2022","unstructured":"Saganowski, S., et al.: Emognition dataset: emotion recognition with self-reports, facial expressions, and physiology using wearables. Sci. Data 9, 158 (2022)","journal-title":"Sci. Data"},{"key":"27_CR31","doi-asserted-by":"crossref","unstructured":"Ringeval, F., et al.: AVEC 2019 workshop and challenge: state-of-mind, detecting depression with AI, and cross-cultural affect recognition (2019)","DOI":"10.1145\/3347320.3357688"},{"key":"27_CR32","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s10579-008-9076-6","volume":"42","author":"C Busso","year":"2008","unstructured":"Busso, C., et al.: IEMOCAP: interactive emotional dyadic motion capture database. Lang. Resour. Eval. 42, 335\u2013359 (2008)","journal-title":"Lang. Resour. Eval."},{"key":"27_CR33","doi-asserted-by":"crossref","unstructured":"Shaffer, F., Ginsberg, J.P.: An overview of heart rate variability metrics and norms. Front. Public Health 5 (2017)","DOI":"10.3389\/fpubh.2017.00258"},{"key":"27_CR34","unstructured":"Gomes, P., Margaritoff, P., Silva, H.: pyHRV: development and evaluation of an open-source python toolbox for heart rate variability (HRV). In: Proceedings of the International Conference on Electrical, Electronic and Computing Engineering (IcETRAN), pp. 822\u2013828 (2019)"},{"key":"27_CR35","doi-asserted-by":"crossref","unstructured":"Eyben, F., W\u00f6llmer, M., Schuller, B.: Opensmile: the Munich versatile and fast open-source audio feature extractor. In: Proceedings of the 18th ACM International Conference on Multimedia, MM 2010, New York, NY, USA, pp. 1459\u20131462, Association for Computing Machinery (2010)","DOI":"10.1145\/1873951.1874246"},{"key":"27_CR36","unstructured":"Ekman, P., Friesen, W.V.: Facial action coding system (2019)"},{"key":"27_CR37","doi-asserted-by":"publisher","first-page":"e17204","DOI":"10.2196\/17204","volume":"7","author":"H Tremain","year":"2020","unstructured":"Tremain, H., McEnery, C., Fletcher, K., Murray, G.: The therapeutic alliance in digital mental health interventions for serious mental illnesses: narrative review. JMIR Ment. Health 7, e17204 (2020)","journal-title":"JMIR Ment. Health"}],"container-title":["Communications in Computer and Information Science","Future Data and Security Engineering. Big Data, Security and Privacy, Smart City and Industry 4.0 Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/978-981-99-8296-7_27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:11:36Z","timestamp":1700179896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/978-981-99-8296-7_27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9789819982950","9789819982967"],"references-count":37,"URL":"https:\/\/doi.org\/10.1007\/978-981-99-8296-7_27","relation":{},"ISSN":["1865-0929","1865-0937"],"issn-type":[{"type":"print","value":"1865-0929"},{"type":"electronic","value":"1865-0937"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"17 November 2023","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"Yongho Lee is an employee of Hippo T &C Inc. And Dr. Tai-Myoung Chung is the Chief Executive Officer of Hippo T &C Inc. Business interest did not influence this research, and neither financial nor material gains were made as a result of it.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"FDSE","order":1,"name":"conference_acronym","label":"Conference Acronym","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"International Conference on Future Data and Security Engineering","order":2,"name":"conference_name","label":"Conference Name","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Da Nang","order":3,"name":"conference_city","label":"Conference City","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Vietnam","order":4,"name":"conference_country","label":"Conference Country","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"2023","order":5,"name":"conference_year","label":"Conference Year","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"22 November 2023","order":7,"name":"conference_start_date","label":"Conference Start Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"24 November 2023","order":8,"name":"conference_end_date","label":"Conference End Date","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"10","order":9,"name":"conference_number","label":"Conference Number","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"fdse2023","order":10,"name":"conference_id","label":"Conference ID","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"http:\/\/thefdse.org\/","order":11,"name":"conference_url","label":"Conference URL","group":{"name":"ConferenceInfo","label":"Conference Information"}},{"value":"Single-blind","order":1,"name":"type","label":"Type","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"EquinOCS","order":2,"name":"conference_management_system","label":"Conference Management System","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"135","order":3,"name":"number_of_submissions_sent_for_review","label":"Number of Submissions Sent for Review","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"38","order":4,"name":"number_of_full_papers_accepted","label":"Number of Full Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"8","order":5,"name":"number_of_short_papers_accepted","label":"Number of Short Papers Accepted","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"28% - The value is computed by the equation \"Number of Full Papers Accepted \/ Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","order":6,"name":"acceptance_rate_of_full_papers","label":"Acceptance Rate of Full Papers","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"3","order":7,"name":"average_number_of_reviews_per_paper","label":"Average Number of Reviews per Paper","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"6","order":8,"name":"average_number_of_papers_per_reviewer","label":"Average Number of Papers per Reviewer","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}},{"value":"Yes","order":9,"name":"external_reviewers_involved","label":"External Reviewers Involved","group":{"name":"ConfEventPeerReviewInformation","label":"Peer Review Information (provided by the conference organizers)"}}]}}