{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:50:29Z","timestamp":1760853029086},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Computer-Aided Mol Des"],"published-print":{"date-parts":[[1990,12]]},"DOI":"10.1007\/bf00117401","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T12:55:35Z","timestamp":1099227335000},"page":"355-367","source":"Crossref","is-referenced-by-count":8,"title":["Molecular modeling studies on the urease active site and the enzyme-catalyzed urea hydrolysis"],"prefix":"10.1007","volume":"4","author":[{"given":"Ramiro","family":"Medina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"M\ufffdller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","volume-title":"Nitrogen Use in World Crop Production","author":"A. Martinez","year":"1985","unstructured":"Martinez, A. and Diamond, R.B., In Hauck, R.D. (Ed.) Nitrogen Use in World Crop Production, American Society of Agronomy, Madison, WI, 1985."},{"key":"CR2","first-page":"1","volume-title":"Ammonia Volatilization from Urea Fertilizers: Importance of Urea Fertilizers","author":"E.A. Harre","year":"1988","unstructured":"Harre, E.A. and Bridges, J.D., In Bock, B.R. and Kissel, D.E. (Eds.) Ammonia Volatilization from Urea Fertilizers: Importance of Urea Fertilizers, National Fertilizer Development Center, Tennessee Valley Authority, Muscle Shoals, AL, 1988, Bulletin Y-206, pp. 1?15."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2136\/sssaj1979.03615995004300020023x","volume":"43","author":"P.L.G. Vlek","year":"1979","unstructured":"Vlek, P.L.G. and Craswell, E.T., Soil Sci. Soc. Am., 43 (1979) 352.","journal-title":"Soil Sci. Soc. Am."},{"key":"CR4","first-page":"189","volume":"3","author":"G.L. Terman","year":"1979","unstructured":"Terman, G.L., Adv. Agron., 3 (1979) 189.","journal-title":"Adv. Agron."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01050196","volume":"2","author":"P.L.G. Vlek","year":"1981","unstructured":"Vlek, P.L.G. and Craswell, E.T., Fertilizer Res., 2 (1981) 227.","journal-title":"Fertilizer Res."},{"key":"CR6","series-title":"Control of Urea Transformations in Soils","first-page":"153","volume-title":"Soil Biochemistry, Vol. 5","author":"R.L. Mulvaney","year":"1981","unstructured":"Mulvaney, R.L. and Bremner, J.M., In Paul, E.A. and Ladd, T.N. (Eds.) Soil Biochemistry, Vol. 5 (Control of Urea Transformations in Soils), Marcel Dekker, Inc., New York, NY, 1981, pp. 153?196."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0304-5102(84)80014-0","volume":"23","author":"R.L. Blakeley","year":"1984","unstructured":"Blakeley, R.L. and Zerner, B., J. Mol. Catal., 23 (1984) 263.","journal-title":"J. Mol. Catal."},{"key":"CR8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0015-3796(17)31206-4","volume":"163","author":"A. Barth","year":"1972","unstructured":"Barth, A. and Michel, J.J., Biochem. Physiol. Planzen, 163 (1972) 103.","journal-title":"Biochem. Physiol. Planzen"},{"key":"CR9","series-title":"Proceedings of the 4th International Conference","first-page":"77","volume-title":"Stable Isotopes","author":"R. Medina","year":"1981","unstructured":"Medina, R., Olleros, T. and Schmidt, H.-L., In Schmidt, H.-L., F\u00f6rstel, H. and Heinzinger, J. (Eds.) Stable Isotopes (Proceedings of the 4th International Conference), J\u00fclich, Elsevier, Amsterdam, 1981, pp. 77?82."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1139\/o80-181","volume":"58","author":"N.E. Dixon","year":"1980","unstructured":"Dixon, N.E., Riddles, P.W., Gazzola, C., Blakeley, R.L. and Zerner, B., Can. J. Biochem., 58 (1980) 1335.","journal-title":"Can. J. Biochem."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1248\/cpb.20.1599","volume":"20","author":"K. Kumani","year":"1972","unstructured":"Kumani, K., Tomioka, S., Kobashi, K. and Hase, J., Chem. Pharm. Bull., 20 (1972) 1599.","journal-title":"Chem. Pharm. Bull."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1248\/bpb1978.3.457","volume":"3","author":"K. Munakata","year":"1980","unstructured":"Munakata, K., Kobashi, K. and Hase, J., J. Pharm. Dyn., 3 (1980) 457.","journal-title":"J. Pharm. Dyn."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1248\/bpb1978.5.49","volume":"5","author":"M. Kanoda","year":"1982","unstructured":"Kanoda, M., Shinida, H., Kobashi, K., Hase, J. and Nagahara, S., J. Pharm. Dyn., 5 (1982) 49.","journal-title":"J. Pharm. Dyn."},{"key":"CR14","first-page":"137","volume-title":"Ammonia Volatilization from Urea Fertilizers: Mechanisms of Urea Inhibition","author":"R. Medina","year":"1988","unstructured":"Medina, R. and Radel, R.J., In Bock, B.R. and Kissel, D.E. (Eds.) Ammonia Volatilization from Urea Fertilizers: Mechanisms of Urea Inhibition, National Fertilizer Development Center, Tennessee Valley Authority, Muscle Shoals, AL, 1988, Bulletin Y-206, pp. 137?174."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/bj2200591","volume":"220","author":"L. Alagna","year":"1984","unstructured":"Alagna, L., Hasnain, S.S., Piggott, B. and Williams, D.J., Biochem. J., 220 (1984) 591.","journal-title":"Biochem. J."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2183\/pjab.61.395","volume":"61","author":"G. Mamiya","year":"1985","unstructured":"Mamiya, G., Takishima, K., Masakuni, M., Kayumi, T., Ogawa, K. and Sekita, T., Proc. Japan Acad., 61 (1985) 395.","journal-title":"Proc. Japan Acad."},{"key":"CR17","first-page":"125","volume-title":"Innovative Approaches in Drug Research","author":"K. M\u00fcller","year":"1986","unstructured":"M\u00fcller, K., Amman, H.J., Doran, D.M., Gerber, P.R. and Schrepfer, G., in Harms, A.F. (Ed.) Innovative Approaches in Drug Research, Elsevier, Amsterdam, 1986, pp. 125?133."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1107\/S0567740878003738","volume":"34","author":"T. Sakurai","year":"1978","unstructured":"Sakurai, T., Iwasaki, H., Katano, T. and Nakahashi, Y., Acta Crystallogr. Sect. B, 34 (1978) 660.","journal-title":"Acta Crystallogr. Sect. B"},{"key":"CR19","doi-asserted-by":"crossref","unstructured":"Fraser, K.A. and Harding, M.M., J. Chem. Soc. A., (1967) 415.","DOI":"10.1039\/j19670000415"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1107\/S0567740872005588","volume":"28","author":"H.C. Freeman","year":"1972","unstructured":"Freeman, H.C. and Guss, J.M., Acta Crystallogr. Sect. B, 28 (1972) 2090.","journal-title":"Acta Crystallogr. Sect. B"},{"key":"CR21","first-page":"287","volume":"93","author":"J.-J. Bonnet","year":"1970","unstructured":"Bonnet, J.-J. and Jeannin, Y., Bull. Soc. Fr. Miner. Cristallogr., 93 (1970) 287?299.","journal-title":"Bull. Soc. Fr. Miner. Cristallogr."},{"key":"CR22","first-page":"61","volume":"95","author":"J.-J. Bonnet","year":"1972","unstructured":"Bonnet, J.-J. and Jeannin, Y., Bull. Soc. Fr. Miner. Cristallogr., 95 (1972) 61?67.","journal-title":"Bull. Soc. Fr. Miner. Cristallogr."},{"key":"CR23","first-page":"1251","volume":"6","author":"A.E. Shvelashvili","year":"1980","unstructured":"Shvelashvili, A.E., Miminoshvili, E.B., Shchedrin, B.M., Kvitashvili, A.I., Kandelaki, M.N., Sakvarelidze, T.N. and Tavberidze, M.G., Koord. Khim., 6 (1980) 1251.","journal-title":"Koord. Khim."},{"key":"CR24","first-page":"85","volume":"4","author":"K.J. Ahmed","year":"1980","unstructured":"Ahmed, K.J., Habib, A., Haider, S.Z., Malik, K.M.A. and Hess, H.J., Bangladesh Acad. Sci., 4 (1980) 85.","journal-title":"Bangladesh Acad. Sci."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1107\/S0108767387099215","volume":"43","author":"P.R. Gerber","year":"1987","unstructured":"Gerber, P.R. and M\u00fcller, K., Acta Crystallogr., A43 (1987) 426.","journal-title":"Acta Crystallogr."},{"key":"CR26","series-title":"Use of Computer Modeling and Structural Databases in Pharmaceutical Research","first-page":"1","volume-title":"Trends in Medical Chemistry, Vol. 88","author":"K. M\u00fcller","year":"1989","unstructured":"M\u00fcller, K., Amman, H.J., Doran, D.M., Gerber, P.R., Gubernator, K. and Schrepfer, G., In Van der, Goot, H., Domany, G., Pallos, L. and Timmerman, H. (Eds.) Trends in Medical Chemistry, Vol. 88 (Use of Computer Modeling and Structural Databases in Pharmaceutical Research). Elsevier, Amsterdam, 1989, pp. 1?12."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/bscb.19880970806","volume":"97","author":"K. M\u00fcller","year":"1988","unstructured":"M\u00fcller, K., Amman, H.J., Doran, D.M., Gerber, P.R., Gubernator, K. and Schrepfer, G., Bull. Soc. Chim. Belg., 97 (1988) 655.","journal-title":"Bull. Soc. Chim. Belg."},{"key":"CR28","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/cr60290a003","volume":"74","author":"R.J. Sundberg","year":"1974","unstructured":"Sundberg, R.J. and Martin, R.B., Chem. Rev., 74 (1974) 471.","journal-title":"Chem. Rev."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1021\/cr00050a003","volume":"82","author":"H. Sigel","year":"1982","unstructured":"Sigel, H. and Martin, R.B., Chem. Rev., 82 (1982) 385.","journal-title":"Chem. Rev."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1016\/S0021-9258(18)97118-8","volume":"240","author":"G.F. Bryce","year":"1965","unstructured":"Bryce, G.F., Roeske, R.W. and Gurd, F.N., J. Biol. Chem., 240 (1965) 3837.","journal-title":"J. Biol. Chem."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1021\/ja01487a064","volume":"82","author":"R.B. Martin","year":"1960","unstructured":"Martin, R.B., Chamberlin, M. and Edsall, J.T., J. Am. Chem. Soc., 82 (1960) 495.","journal-title":"J. Am. Chem. Soc."},{"key":"CR32","doi-asserted-by":"crossref","unstructured":"Freeman, H.C., Guss, J.M. and Sinclair, R.L., J. Chem. Soc. Chem. Commun., (1968) 485.","DOI":"10.1039\/c19680000485"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1021\/ja00996a010","volume":"89","author":"M.K. Kim","year":"1967","unstructured":"Kim, M.K. and Martell, A.E., J. Am. Chem. Soc., 89 (1967) 5138.","journal-title":"J. Am. Chem. Soc."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/ja01490a023","volume":"82","author":"R.B. Martin","year":"1960","unstructured":"Martin, R.B. and Edsall, J.T., J. Am. Chem. Soc., 82 (1960) 1107.","journal-title":"J. Am. Chem. Soc."},{"key":"CR35","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/ja00981a009","volume":"89","author":"D.W. Margerum","year":"1967","unstructured":"Margerum, D.W. and Rosen, H.M., J. Am. Chem. Soc., 89 (1967) 1088.","journal-title":"J. Am. Chem. Soc."},{"key":"CR36","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1021\/ja00710a014","volume":"92","author":"J.P. Jones","year":"1970","unstructured":"Jones, J.P., Billo, E.J. and Margerum, D.W., J. Am. Chem. Soc., 92 (1970) 1875.","journal-title":"J. Am. Chem. Soc."},{"key":"CR37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0167-4838(83)90094-8","volume":"744","author":"R.L. Blakeley","year":"1983","unstructured":"Blakeley, R.L., Dixon, N.E. and Zerner, B., Biochim. Biophys. Acta, 744 (1983) 219.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1139\/o80-063","volume":"58","author":"R.E. Dixon","year":"1980","unstructured":"Dixon, R.E., Gazzola, C., Asher, C.J., Lee, D.S.W., Blakeley, R.L. and Zerner, B., Can. J. Biochem., 58 (1980) 474.","journal-title":"Can. J. Biochem."},{"key":"CR39","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1021\/bi00833a031","volume":"8","author":"R.L. Blakeley","year":"1969","unstructured":"Blakeley, R.L., Webb, E.C. and Zerner, B., Biochemistry, 8 (1969) 1984.","journal-title":"Biochemistry"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1021\/ja00847a045","volume":"97","author":"N.E. Dixon","year":"1975","unstructured":"Dixon, N.E., Gazzola, C., Blakeley, R.L. and Zerner, B., J. Am. Chem. Soc., 97 (1975) 4131.","journal-title":"J. Am. Chem. Soc."},{"key":"CR41","unstructured":"Williams, R.J.P., J. Mol. Catalysis, Review Issue (1986), pp. 1?27."},{"key":"CR42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1021\/ja00314a057","volume":"106","author":"K.D. Hardman","year":"1984","unstructured":"Hardman, K.D. and Lipscomb, W.N., J. Am. Chem. Soc., 106 (1984) 463.","journal-title":"J. Am. Chem. Soc."},{"key":"CR43","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1021\/ja00282a059","volume":"108","author":"R.K. Andrews","year":"1986","unstructured":"Andrews, R.K., Dexter, A., Blakeley, R.L. and Zerner, B., J. Am. Chem. Soc., 108 (1986) 7124.","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00117401.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00117401\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00117401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T08:43:29Z","timestamp":1624783409000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00117401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["BF00117401"],"URL":"https:\/\/doi.org\/10.1007\/bf00117401","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"type":"print","value":"0920-654X"},{"type":"electronic","value":"1573-4951"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}