{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T17:53:08Z","timestamp":1679680388262},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1994,4,1]],"date-time":"1994-04-01T00:00:00Z","timestamp":765158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Computer-Aided Mol Des"],"published-print":{"date-parts":[[1994,4]]},"DOI":"10.1007\/bf00119863","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T17:09:57Z","timestamp":1099415397000},"page":"123-134","source":"Crossref","is-referenced-by-count":6,"title":["Semi-rigid analogues of the calcium antagonist verapamil: A molecular modelling study"],"prefix":"10.1007","volume":"8","author":[{"given":"Maria Novella","family":"Romanelli","sequence":"first","affiliation":[]},{"given":"Silvia","family":"Dei","sequence":"additional","affiliation":[]},{"given":"Serena","family":"Scapecchi","sequence":"additional","affiliation":[]},{"given":"Elisabetta","family":"Teodori","sequence":"additional","affiliation":[]},{"given":"Fulvio","family":"Gualtieri","sequence":"additional","affiliation":[]},{"given":"Roberta","family":"Budriesi","sequence":"additional","affiliation":[]},{"given":"Raimund","family":"Mannhold","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0006-2952(90)90255-J","volume":"39","author":"E. McKenna","year":"1990","unstructured":"McKenna E., Koch W.J., Slish D.F. and Schwartz A., Biochem. Pharmacol., 39 (1990) 1145.","journal-title":"Biochem. Pharmacol."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0165-6147(84)90446-2","volume":"7","author":"G. Fleckenstein-Grun","year":"1984","unstructured":"Fleckenstein-Grun G., Frey M. and Fleckenstein A., Trends Pharmacol. Sci., 7 (1984) 283.","journal-title":"Trends Pharmacol. Sci."},{"issue":"suppl. 3","key":"CR3","first-page":"107","volume":"79","author":"W.G. Nayler","year":"1990","unstructured":"Nayler W.G., Z. Kardiol. 79, suppl. 3 (1990) 107.","journal-title":"Z. Kardiol."},{"key":"CR4","first-page":"419","volume":"37","author":"R. Mannhold","year":"1987","unstructured":"Mannhold R., Bayer R., Ronsdorf M. and Martens L., Arzneim. Forsch.\/Drug Res., 37 (1987) 419.","journal-title":"Arzneim. Forsch.\/Drug Res."},{"key":"CR5","volume-title":"Recent Advances in Receptor Chemistry","author":"R. Mannhold","year":"1988","unstructured":"Mannhold R., In Melchiorre C. and Giannella M. (Eds.) Recent Advances in Receptor Chemistry, Elsevier, Amsterdam, 1988, p. 147, and references cited therein."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/jps.2600751014","volume":"75","author":"G.S. Retzinger","year":"1986","unstructured":"Retzinger G.S., Cohen L., Lau S.H. and Kezdy F.J., J. Pharm. Sci., 75 (1986) 976.","journal-title":"J. Pharm. Sci."},{"key":"CR7","first-page":"721","volume":"242","author":"L. Cohen","year":"1987","unstructured":"Cohen L., Vereault D., Wasserstrom J.A., Retzinger G.S. and Kezdy F.J., J. Pharmacol. Exp. Ther., 242 (1987) 721.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CR8","first-page":"624","volume":"41","author":"A. Carpy","year":"1985","unstructured":"Carpy A., Leger J.M. and Melchiorre C., Acta Crystallogr., C41 (1985) 624.","journal-title":"Acta Crystallogr."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/jps.2600800618","volume":"80","author":"A. Maccotta","year":"1991","unstructured":"Maccotta A., Scibona G., Valensin G., Gaggelli E., Botr\u00e9 F. and Botr\u00e9 C., J. Pharm. Sci., 80 (1991) 586.","journal-title":"J. Pharm. Sci."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0378-5173(92)90111-E","volume":"79","author":"B. Fernandez","year":"1992","unstructured":"Fernandez B., Mosquera R. and Uriarte E., Int. J. Pharm., 79 (1992) 199.","journal-title":"Int. J. Pharm."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00508786","volume":"334","author":"A. Goll","year":"1986","unstructured":"Goll A., Glossmann H. and Mannhold R., Naunyn-Schmiedeberg's Arch. Pharmacol., 334 (1986) 303.","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1021\/jm00167a033","volume":"33","author":"M. Reiffen","year":"1990","unstructured":"Reiffen M., Eberlein W., Mueller P., Psiorz M., Noll K., Heider J., Lillie C., Kobinger W. and Luger P., J. Med. Chem., 33 (1990) 1496.","journal-title":"J. Med. Chem."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1021\/jm00111a043","volume":"34","author":"S. Dei","year":"1991","unstructured":"Dei S., Romanelli M.N., Scapecchi S., Teodori E., Chiarini A. and Gualtieri F., J. Med. Chem., 34 (1991) 2219.","journal-title":"J. Med. Chem."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1021\/jm00056a003","volume":"36","author":"S. Dei","year":"1993","unstructured":"Dei S., Romanelli M.N., Scapecchi S., Teodori E., Gualtieri F., Chiarini A., Voigt W. and Lemoine H., J. Med. Chem., 36 (1993) 439.","journal-title":"J. Med. Chem."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0223-5234(90)90119-N","volume":"25","author":"M. Laguerre","year":"1990","unstructured":"Laguerre M., Boyer C., Carpy A., Cognic F. and Vangien B., Eur. J. Med. Chem., 25 (1990) 351.","journal-title":"Eur. J. Med. Chem."},{"key":"CR16","first-page":"449","volume":"44","author":"M.N. Romanelli","year":"1989","unstructured":"Romanelli M.N., Gualtieri F., Mannhold R. and Chiarini A., Il Farmaco, 44 (1989) 449.","journal-title":"Il Farmaco"},{"key":"CR17","unstructured":"5,6-Dimethoxy-2-(methylamino)-indan was prepared according to Ref. 24 and 6,7-dimethoxy-2-(methylamino)-tetraline according to Ref. 25. 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline was commercially available."},{"key":"CR18","first-page":"1167","volume":"44","author":"C. Bellucci","year":"1989","unstructured":"Bellucci C., Gualtieri F., Scapecchi S., Teodori E., Budriesi R. and Chiarini A., Il Farmaco, 44 (1989) 1167.","journal-title":"Il Farmaco"},{"key":"CR19","unstructured":"H\u00f6ltje, H.-D., Mannhold, R., Rodenkirchen, R. and Bayer, R., Naunyn-Schmiedeberg's Arch. Pharmacol., 316 (1981) R33."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/qsar.19890080402","volume":"8","author":"H.-D. H\u00f6ltje","year":"1989","unstructured":"H\u00f6ltje H.-D. and Maurhofer E., Quant. Struct.-Act. Relatsh., 8 (1989) 259.","journal-title":"Quant. Struct.-Act. Relatsh."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1021\/jm00388a010","volume":"30","author":"F.I. Carrol","year":"1987","unstructured":"For an analogue approach see, for instance, Carrol F.I., Abraham P., Parham K., Griffith R.C., Ahmad A., Richard M.M., Padilla F.N., Wirkin J.M. and Chang P.K., J. Med. Chem., 30 (1987) 805.","journal-title":"J. Med. Chem."},{"key":"CR22","volume-title":"Calcium Antagonists","author":"E. Burke","year":"1987","unstructured":"Burke E., In Nayler W.G. (Ed.) Calcium Antagonists, Academic Press, London, 1987, p. 101."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3987\/R-1987-05-1291","volume":"26","author":"R.D. Clark","year":"1987","unstructured":"Clark R.D., Berger J., Chi-Ho L. and Muchowski J.M., Heterocycles, 26 (1987) 1291.","journal-title":"Heterocycles"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1021\/jm00354a010","volume":"25","author":"J.G. Cannon","year":"1982","unstructured":"Cannon J.G., Perez J.A., Bhatnagar R.K., Lang J.P. and Sharabi F.M., J. Med. Chem., 25 (1982) 1442.","journal-title":"J. Med. Chem."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1021\/jm00219a001","volume":"20","author":"J.G. Cannon","year":"1977","unstructured":"Cannon J.G., Lee T. and Goldman H.D., J. Med. Chem., 20 (1977) 1111.","journal-title":"J. Med. Chem."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00119863.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00119863\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00119863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T09:11:24Z","timestamp":1554282684000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00119863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["BF00119863"],"URL":"https:\/\/doi.org\/10.1007\/bf00119863","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}