{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T20:37:38Z","timestamp":1770410258524,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Computer-Aided Mol Des"],"published-print":{"date-parts":[[1992,6]]},"DOI":"10.1007\/bf00123378","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T09:59:02Z","timestamp":1099216742000},"page":"223-233","source":"Crossref","is-referenced-by-count":30,"title":["An approach to computer-aided inhibitor design: Application to cathepsin L"],"prefix":"10.1007","volume":"6","author":[{"given":"Sucha","family":"Sudarsanam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Duke","family":"Virca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl J.","family":"March","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhashini","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0022-2836(82)90153-X","volume":"161","author":"I.D. Kuntz","year":"1982","unstructured":"Kuntz, I.D., Blaney, J.M., Oatley, S.J., Langridge, R. and Ferrin, T.E., J. Mol. Biol., 161 (1982) 269.","journal-title":"J. Mol. Biol."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1073\/pnas.87.17.6644","volume":"87","author":"R.L. DesJarlais","year":"1990","unstructured":"DesJarlais, R.L., Seibel, G.L., Kuntz, I.D., Furth, P.S., Alvarez, J.C., Ortiz de Montellano, P.R., DeCamp, D.L., Babe, L.M. and Craik, C.S., Proc. Natl. Acad. Sci. USA, 87 (1990) 6644.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/prot.340070404","volume":"7","author":"J. Greer","year":"1990","unstructured":"Greer, J., Proteins: Structure, Function and Genetics, 7 (1990) 317.","journal-title":"Proteins: Structure, Function and Genetics"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0014-5793(88)80028-0","volume":"228","author":"A. Ritonja","year":"1984","unstructured":"Ritonja, A., Popovic, T., Kotnic, M., Machleidt, W. and Turk, V., FEBS Lett., 228 (1984) 341.","journal-title":"FEBS Lett."},{"key":"CR5","volume-title":"Biological Functions of Proteins","author":"P. Bohley","year":"1979","unstructured":"Bohley, P., Kirschke, H., Langer, J., Miehe, M., Riemann, S., Slama, Z., Schon, E., Weideranders, B. and Ansorge, S., In: Holzer, H. and Tschesche, H. (Eds.) Biological Functions of Proteins, Springer-Verlag, Berlin, 1979, p. 17."},{"key":"CR6","volume-title":"Cysteine Proteinases and Their Inhibitors","author":"J.M. Delaisse","year":"1986","unstructured":"Delaisse, J.M., Ledent, P., Eeckhout, Y. and Vaes, G., In: Turk, V. (Ed.) Cysteine Proteinases and Their Inhibitors, Walter de Gruyter, Berlin, 1986, p. 259."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.2879353","volume":"235","author":"J.L. Marx","year":"1987","unstructured":"Marx, J.L., Science, 235 (1987) 285.","journal-title":"Science"},{"key":"CR8","first-page":"55","volume":"2","author":"D.T. Denhardt","year":"1987","unstructured":"Denhardt, D.T., Greenberg, A.H., Egan, S.E., Hamilton, R.T. and Wright, J.A., Oncogene, 2 (1987) 55.","journal-title":"Oncogene"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF00048388","volume":"3","author":"B.F. Sloane","year":"1984","unstructured":"Sloane, B.F. and Honn, K.V., Cancer Metastasis Rev., 3 (1984) 249.","journal-title":"Cancer Metastasis Rev."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/0006-291X(89)91755-5","volume":"164","author":"J. Rozhin","year":"1989","unstructured":"Rozhin, J., Wade, R.L., Honn, K.V. and Sloane, B.F., Biochem. Biophys. Res. Commun., 164 (1989) 556.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"CR11","first-page":"1525","volume":"15","author":"C.J.F. VanNoorden","year":"1988","unstructured":"VanNoorden, C.J.F., Smith, R.E. and Rasnick, D., J. Rheumatol., 15 (1988) 1525.","journal-title":"J. Rheumatol."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-0765.1985.tb00828.x","volume":"20","author":"T. Lah","year":"1985","unstructured":"Lah, T., Skaleric, U., Babnik, J. and Turk, V., J. Periodontal Res., 20 (1985) 458.","journal-title":"J. Periodontal Res."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1600-0765.1986.tb01486.x","volume":"21","author":"T. Lah","year":"1986","unstructured":"Lah, T., Skaleric, U., Babnik, J. and Turk, V., J. Periodontal Res., 21 (1986) 504.","journal-title":"J. Periodontal Res."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00690529","volume":"75","author":"M. Sano","year":"1988","unstructured":"Sano, M., Wada, Y., Ii, K., Katunama, N. and Tsukagoshi, H., Acta Neuropathol., 75 (1988) 217.","journal-title":"Acta Neuropathol."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1093\/oxfordjournals.jbchem.a135018","volume":"96","author":"E. Kominami","year":"1984","unstructured":"Kominami, E., Bando, Y., Ii, K., Hizawa, K. and Katunama, N., J. Biochem. (Tokyo), 96 (1984) 1841.","journal-title":"J. Biochem. (Tokyo)"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1042\/bj2330925","volume":"233","author":"R.W. Mason","year":"1986","unstructured":"Mason, R.W., Johnson, D.A., Barrett, A.J. and Chapman, H.A., Biochem. J., 233 (1986) 925.","journal-title":"Biochem. J."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"14748","DOI":"10.1016\/S0021-9258(18)66935-2","volume":"261","author":"D.A. Johnson","year":"1986","unstructured":"Johnson, D.A., Barrett, A.J. and Mason, R.W., J. Biol. Chem., 261 (1986) 14748.","journal-title":"J. Biol. Chem."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0304-4165(89)80041-8","volume":"990","author":"G.J. Thomas","year":"1989","unstructured":"Thomas, G.J. and Davies, M., Biochim. Biophys. Acta, 990 (1989) 246.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/bj2010367","volume":"201","author":"H. Kirschke","year":"1982","unstructured":"Kirschke, H., Kembhavi, A.A., Bohley, P. and Barrett, A.J., Biochem. J., 201 (1982) 367.","journal-title":"Biochem. J."},{"key":"CR20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1515\/bchm3.1986.367.1.39","volume":"367","author":"K. Tsuchida","year":"1981","unstructured":"Tsuchida, K., Aihara, H., Isogai, K., Hanada, K. and Kato, H., Hoppe-Seyler's Z. Physiol. Chem., 367 (1981) 39.","journal-title":"Hoppe-Seyler's Z. Physiol. Chem."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0005-2744(81)90221-7","volume":"662","author":"U. Matsukura","year":"1981","unstructured":"Matsukura, U., Okitani, A., Nishimuro, T. and Kato, H., Biochim. Biophys. Acta, 662 (1981) 41.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/bj2520301","volume":"252","author":"W.H. Baricos","year":"1988","unstructured":"Baricos, W.H., Zhou, Y., Mason, R.W. and Barrett, A.J., Biochem. J., 252 (1988) 301.","journal-title":"Biochem. J."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0022-2836(84)90467-4","volume":"179","author":"I.G. Kamphuis","year":"1984","unstructured":"Kamphuis, I.G., Kalk, K.H., Swarte, M.B.A. and Drenth, J., J. Mol. Biol., 179 (1984) 233.","journal-title":"J. Mol. Biol."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/c160050a006","volume":"13","author":"F.H. Allen","year":"1973","unstructured":"Allen, F.H., Kennard, O., Motherwell, W.D.S., Town, W.G. and Watson, D.G., J. Chem. Doc., 13 (1973) 119.","journal-title":"J. Chem. Doc."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1107\/S0567740879009249","volume":"35","author":"F.H. Allen","year":"1979","unstructured":"Allen, F.H., Bellard, S., Brice, M.D., Cartwright, B.A., Doubleday, A., Higgs, H., Hummelink, T., Hummelink-Peters, B.G., Kennard, O., Motherwell, W.D.S., Rodgers, J.R. and Watson, D.G., Acta Crytallogr. B, 35 (1979) 2331.","journal-title":"Acta Crytallogr. B"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1021\/ja00412a053","volume":"103","author":"Y.Y. Lin","year":"1981","unstructured":"Lin, Y.Y., Risk, M., Ray, S.M., VanEngen, D., Clardy, J., Golik, J., James, J.C. and Nakanishi, K., J. Am. Chem. Soc., 103 (1981) 6773.","journal-title":"J. Am. Chem. Soc."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(89)90295-X","volume":"59","author":"B. Mosley","year":"1989","unstructured":"Mosley, B., Beckman, M.P., March, C.J., Idzerda, R.I., Gimpel, S.D., VandenBos, T., Friend, D., Alpert, A., Andersen, D., Jackson, J., Wignall, J.M., Smith, C., Gallis, B., Sims, J.E., Urdall, D., Widmer, M.B., Cosman, D. and Park, L.S., Cell, 59 (1989) 335.","journal-title":"Cell"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0378-1119(87)90288-5","volume":"55","author":"V. Price","year":"1987","unstructured":"Price, V., Mochizuki, D., March, C.J., Cosman, D., Deely, M.C., Klinke, R., Clevenger, W., Gillis, S., Baker, P. and Urdall, D., Gene, 55 (1987) 287.","journal-title":"Gene"},{"key":"CR29","first-page":"83","volume-title":"Proteolytic Enzymes: A Practical Approach","author":"G. Salvesean","year":"1989","unstructured":"Salvesean, G. and Nagese, H, In: Beynon, R.J. and Bond, J.S. (Eds.) Proteolytic Enzymes: A Practical Approach, IRL Press, Oxford, 1989, pp. 83?104."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/ja01318a036","volume":"56","author":"H. Lineweaver","year":"1934","unstructured":"Lineweaver, H. and Burke, D., J. Am. Chem. Soc., 56 (1934) 658.","journal-title":"J. Am. Chem. Soc."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0021-9258(18)72452-6","volume":"146","author":"G.S. Eadie","year":"1942","unstructured":"Eadie, G.S., J. Biol. Chem., 146 (1942) 85.","journal-title":"J. Biol. Chem."},{"key":"CR32","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/1841296b0","volume":"184","author":"B.N.J. Hofstee","year":"1959","unstructured":"Hofstee, B.N.J., Nature, 184 (1959) 1296.","journal-title":"Nature"}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00123378.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00123378\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00123378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T08:21:28Z","timestamp":1624782088000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00123378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["BF00123378"],"URL":"https:\/\/doi.org\/10.1007\/bf00123378","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}