{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:34:47Z","timestamp":1770885287438,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Computer-Aided Mol Des"],"published-print":{"date-parts":[[1995,12]]},"DOI":"10.1007\/bf00124324","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T12:57:37Z","timestamp":1099227457000},"page":"532-549","source":"Crossref","is-referenced-by-count":341,"title":["A genetic algorithm for flexible molecular overlay and pharmacophore elucidation"],"prefix":"10.1007","volume":"9","author":[{"given":"Gareth","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Willett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Glen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/jm00034a001","volume":"37","author":"J. Greer","year":"1994","unstructured":"Greer, J., Erickson, J.W., Baldwin, J.J. and Varney, M.D., J. Med. Chem., 37 (1994) 1035.","journal-title":"J. Med. Chem."},{"key":"CR2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1021\/bk-1979-0112.ch009","volume-title":"Computer Assisted Drug Design, American Chemical Society Symposium Series, Vol. 112","author":"G.R. Marshall","year":"1979","unstructured":"Marshall, G.R., Barry, C.D., Bosshard, H.E., Dammkoehler, R.A. and Dunn, D.A., In Olson, E.C. and Christofferson, R.E. (Eds.) Computer Assisted Drug Design, American Chemical Society Symposium Series, Vol. 112, American Chemical Society, Washington, DC, 1979, pp. 205?226."},{"key":"CR3","first-page":"173","volume-title":"3D QSAR in Drug Design: Theory, Methods and Applications","author":"G. Klebe","year":"1993","unstructured":"Klebe, G., In Kubinyi, H. (Ed.) 3D QSAR in Drug Design: Theory, Methods and Applications, ESCOM, Leiden, 1993, pp. 173?199."},{"key":"CR4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0263-7855(93)87001-L","volume":"11","author":"A.W.R. Payne","year":"1993","unstructured":"Payne, A.W.R. and Glen, R.C., J. Mol. Graphics, 11 (1993) 74.","journal-title":"J. Mol. Graphics"},{"key":"CR5","volume-title":"Genetic Algorithms in Search, Optimization and Machine Learning","author":"D.E. Goldberg","year":"1989","unstructured":"Goldberg, D.E., Genetic Algorithms in Search, Optimization and Machine Learning, Addison-Wesley, Wokingham, 1989."},{"key":"CR6","volume-title":"Handbook of Genetic Algorithms","year":"1991","unstructured":"Davis, L. (Ed.) Handbook of Genetic Algorithms, Van Nostrand Reinhold, New York, NY, 1991."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.8346439","volume":"261","author":"S. Forrest","year":"1993","unstructured":"Forrest, S., Science, 261 (1993) 872.","journal-title":"Science"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-2836(95)80037-9","volume":"245","author":"G. Jones","year":"1995","unstructured":"Jones, G., Willett, P. and Glen, R.C., J. Mol. Biol., 245 (1995) 43.","journal-title":"J. Mol. Biol."},{"key":"CR9","unstructured":"SYBYL molecular modelling software, available from Tripos Associates Inc., St. Louis, MO."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1021\/ci60005a013","volume":"16","author":"A. Zamora","year":"1976","unstructured":"Zamora, A., J. Chem. Inf. Comput. Sci., 16 (1976) 40.","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/978-94-009-3133-6_4","volume-title":"Multivariate Analysis of Ecological Communities","author":"P.G.N. Digby","year":"1987","unstructured":"Digby, P.G.N. and Kempton, R.A., Multivariate Analysis of Ecological Communities, Chapman and Hall, London, 1987, pp. 112?115."},{"key":"CR12","volume-title":"Molecular Theory of Gases and Liquids","author":"J.O. Hirschfelder","year":"1964","unstructured":"Hirschfelder, J.O., Curtiss, C.E. and Bird, R.B., Molecular Theory of Gases and Liquids, Wiley, New York, NY, 1964."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcc.540100804","volume":"10","author":"M. Clark","year":"1989","unstructured":"Clark, M., Cramer III, R.D. and Van Opdenbosch, N., J. Comput. Chem., 10 (1989) 982.","journal-title":"J. Comput. Chem."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1021\/ci00017a008","volume":"34","author":"R.D. Brown","year":"1994","unstructured":"Brown, R.D., Jones, G., Willett, P. and Glen, R.C., J. Chem. Inf. Comput. Sci., 34 (1994) 63.","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"CR15","first-page":"176","volume-title":"Parallel Problem Solving From Nature","author":"T. Starkweather","year":"1990","unstructured":"Starkweather, T., Whitley, D. and Mathias, K., In Schwefel, H.P. and Manner, R. (Eds.) Parallel Problem Solving From Nature, Springer, Berlin, 1990, pp. 176?185."},{"key":"CR16","first-page":"434","volume-title":"Proceedings of the Third International Conference on Genetic Algorithms and their Applications","author":"R. Tanese","year":"1989","unstructured":"Tanese, R., In Schaffer, D. (Ed.) Proceedings of the Third International Conference on Genetic Algorithms and their Applications, Morgan Kaufmann, San Mateo, CA, 1989, pp. 434?439."},{"key":"CR17","unstructured":"Jones, G., Ph.D. Thesis, University of Sheffield, Western Bank, 1995."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1021\/jm00100a007","volume":"35","author":"R.H. Bradbury","year":"1992","unstructured":"Bradbury, R.H., Allott, C.P., Dennis, M., Fisher, E., Major, J.S., Masek, B.B., Oldham, A.A., Pearce, R.J., Rankine, N., Revill, J.M., Roberts, D.A. and Russell, S.T., J. Med. Chem., 35 (1992) 4227.","journal-title":"J. Med. Chem."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1021\/jm00061a014","volume":"36","author":"B.B. Masek","year":"1993","unstructured":"Masek, B.B., Merchant, A. and Matthew, J.B., J. Med. Chem., 36 (1993) 1230.","journal-title":"J. Med. Chem."},{"key":"CR20","first-page":"49","volume":"36","author":"V.M. Kolb","year":"1991","unstructured":"Kolb, V.M., Prog. Drug Res., 36 (1991) 49.","journal-title":"Prog. Drug Res."},{"key":"CR21","first-page":"307","volume":"34","author":"R.C. Glen","year":"1994","unstructured":"Glen, R.C., Hill, A.P., Martin, G.R. and Robertson, A.D., Headache, 34 (1994) 307.","journal-title":"Headache"},{"key":"CR22","first-page":"178","volume":"28","author":"P.W. Codding","year":"1985","unstructured":"Codding, P.W. and Muir, A.K.S., Mol. Pharmacol., 28 (1985) 178.","journal-title":"Mol. Pharmacol."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1021\/jm00070a008","volume":"36","author":"R.D. Clark","year":"1993","unstructured":"Clark, R.D., Miller, A.B., Berger, J., Repke, D.B., Weinhardt, K.K., Kowalczyk, B.A., Eglen, R.M., Bonhaus, D.W., Lee, C., Michel, A.D., Smith, W.L. and Wong, E.H.F., J. Med. Chem., 36 (1993) 2645.","journal-title":"J. Med. Chem."},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1021\/jm00087a003","volume":"25","author":"G. Bradley","year":"1992","unstructured":"Bradley, G., Ward, T.J., White, J.C., Coleman, J., Taylor, A. and Rhodes, K.F., J. Med. Chem., 25 (1992) 1515.","journal-title":"J. Med. Chem."},{"key":"CR25","first-page":"55","volume-title":"A Textbook of Drug Design and Development","author":"T. H\u00f6berg","year":"1992","unstructured":"H\u00f6berg, T. and Norinder, U., In Krogsgaard-Larsen, P. and Bundgaard, H. (Eds.) A Textbook of Drug Design and Development, Harwood Academic Publishers, Reading, 1992, pp. 55?91."},{"key":"CR26","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/jcc.540140809","volume":"14","author":"M. Froimowitz","year":"1993","unstructured":"Froimowitz, M., J. Comput. Chem., 14 (1993) 934.","journal-title":"J. Comput. Chem."},{"key":"CR27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00126442","volume":"7","author":"T.D.J. Perkins","year":"1993","unstructured":"Perkins, T.D.J. and Dean, P.M., J. Comput.-Aided Mol. Design, 7 (1993) 155.","journal-title":"J. Comput.-Aided Mol. Design"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/jmbi.1993.1012","volume":"229","author":"G.D. Duyne Van","year":"1993","unstructured":"Van Duyne, G.D., Standaert, R.F., Karplus, P.A., Schreiber, S.L. and Clardy, J., J. Mol. Biol., 229 (1993) 105.","journal-title":"J. Mol. Biol."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-2836(77)80200-3","volume":"112","author":"F.C. Bernstein","year":"1977","unstructured":"Bernstein, F.C., Koetzle, T.F., Williams, G.J.B., Meyer, F., Bryce, M.D., Rodgers, J.R., Kennard, O., Shimanouchi, T. and Tasumi, M., J. Mol. Biol., 112 (1977) 535.","journal-title":"J. Mol. Biol."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"9925","DOI":"10.1021\/ja00075a008","volume":"115","author":"D.A. Holt","year":"1993","unstructured":"Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H., Konialian, A.L., Yen, H., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Liang, J., Schultz, L.W., Stout, T.J. and Clardy, J., J. Am. Chem. Soc., 115 (1993) 9925.","journal-title":"J. Am. Chem. Soc."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1399-3011.1994.tb00561.x","volume":"43","author":"P.N. Sanderson","year":"1994","unstructured":"Sanderson, P.N., Glen, R.C., Payne, A.W.R., Hudson, B.D., Heide, C., Tranter, G.E., Doyle, P.M. and Harris, C.J., Int. J. Pept. Protein Res., 43 (1994) 588.","journal-title":"Int. J. Pept. Protein Res."},{"key":"CR32","volume-title":"3D QSAR in Drug Design: Theory, Methods and Applications","year":"1993","unstructured":"Kubinyi, H. (Ed.) 3D QSAR in Drug Design: Theory, Methods and Applications, ESCOM, Leiden, 1993."},{"key":"CR33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00141574","volume":"7","author":"J.A. Calder","year":"1993","unstructured":"Calder, J.A., Wyatt, J.A., Frenkel, D.A. and Casida, J.E., J. Comput.-Aided Mol. Design, 7 (1993) 45.","journal-title":"J. Comput.-Aided Mol. Design"},{"key":"CR34","volume-title":"Molecular Similarity in Drug Design","year":"1994","unstructured":"Dean, P.M. (Ed.) Molecular Similarity in Drug Design, Blackie, Glasgow, 1994."},{"key":"CR35","unstructured":"Downs, G.M. and Willett, P., Rev. Comput. Chem., in press."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00124324.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00124324\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00124324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T05:17:39Z","timestamp":1554268659000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00124324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["BF00124324"],"URL":"https:\/\/doi.org\/10.1007\/bf00124324","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}