{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:17:42Z","timestamp":1760782662440},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Computer-Aided Mol Des"],"published-print":{"date-parts":[[1990,9]]},"DOI":"10.1007\/bf00125013","type":"journal-article","created":{"date-parts":[[2004,10,31]],"date-time":"2004-10-31T12:01:44Z","timestamp":1099224104000},"page":"239-253","source":"Crossref","is-referenced-by-count":13,"title":["The conformational preferences of ?-lactam and its role in constraining peptide structure"],"prefix":"10.1007","volume":"4","author":[{"given":"P. K. C.","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Burney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Osguthorpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/bip.360280125","volume":"28","author":"C. Toniolo","year":"1989","unstructured":"Toniolo, C., Biopolymers, 28 (1989) 247.","journal-title":"Biopolymers"},{"issue":"3","key":"CR2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0024-3205(82)90578-1","volume":"31","author":"V.J. Hruby","year":"1982","unstructured":"Hruby, V.J., Life Sci., 31 (3) (1982) 189.","journal-title":"Life Sci."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.7001627","volume":"210","author":"R.M. Freidinger","year":"1980","unstructured":"Freidinger, R.M., Veber, D.F., Perlow, D.S., Brooks, J.R. and Saperstein, R., Science, (210 1980) 656.","journal-title":"Science"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1399-3011.1980.tb02970.x","volume":"16","author":"R.M. Freidinger","year":"1980","unstructured":"Freidinger, R.M., Veber, D.F., Hirschmann, R. and Paege, L.M., Int. J. Pept. Prot. Res., 16 (1980) 464.","journal-title":"Int. J. Pept. Prot. Res."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1021\/jo00340a023","volume":"47","author":"R.M. Freidinger","year":"1982","unstructured":"Freidinger, R.M., Perlow, D.S. and Veber, D.F., J. Org. Chem., 47 (1982) 104.","journal-title":"J. Org. Chem."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1021\/jm00402a021","volume":"31","author":"S. Thaisrivongs","year":"1988","unstructured":"Thaisrivongs, S., Pals, D.T., Turner, S.R. and Kroll, L.T., J. Med. Chem., 31 (1988) 1369.","journal-title":"J. Med. Chem."},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1021\/jm00402a031","volume":"31","author":"K.L. Yu","year":"1988","unstructured":"Yu, K.L., Rajakumar, G., Srivastava, L.K., Mishra, R.K. and Johnson, R.L., J. Med. Chem., 31 (1988) 1430.","journal-title":"J. Med. Chem."},{"key":"CR8","first-page":"203","volume":"5","author":"R.K. Mishra","year":"1983","unstructured":"Mishra, R.K., Chiu, S., Chiu, P. and Mishra, C. P., Methods Find. Exp. Clin. Pharmacol., 5 (1983) 203.","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"CR9","series-title":"Proceedings of the 7th American Peptide Symposium","first-page":"673","volume-title":"Peptides: Synthesis-Structure-Function","author":"R.M. Freidinger","year":"1981","unstructured":"Freidinger, R.M., In Rich, D.H. and Gross, E. (Eds.) Peptides: Synthesis-Structure-Function (Proceedings of the 7th American Peptide Symposium), Pierce Chemical Co., Rockford, IL., 1981, pp. 673?684."},{"key":"CR10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1399-3011.1989.tb00207.x","volume":"33","author":"G. Valle","year":"1989","unstructured":"Valle, G., Crisma, M., Toniolo, C., Yu, K.L. and Johnson, R.L., Int. J. Pept. Prot. Res., 33 (1989) 181.","journal-title":"Int. J. Pept. Prot. Res."},{"key":"CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1039\/p29890000083","volume":"II","author":"G. Valle","year":"1989","unstructured":"Valle, G., Crisma, M., Toniolo, C., Yu, K.L. and Johnson, R.L., J. Chem. Soc. Perkins Trans. II (1989) 83.","journal-title":"J. Chem. Soc. Perkins Trans."},{"key":"CR12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0371-1951(63)80095-8","volume":"19","author":"R.G. Snyder","year":"1963","unstructured":"Snyder, R.G. and Schachtschneider, J.H., Spectrochim. Acta, 19 (1963) 85.","journal-title":"Spectrochim. Acta"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1021\/bk-1981-0173.ch012","volume":"173","author":"P. Dauber","year":"1981","unstructured":"Dauber, P., Goodman, M., Hagler, A.T., Osguthorpe, D.J., Sharon, R. and Stern, P.S., Proc. ACS Symp. on Supercomputers in Chemistry, 173 (1981) 161.","journal-title":"Proc. ACS Symp. on Supercomputers in Chemistry"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/prot.340040106","volume":"4","author":"P. Dauber-Osguthorpe","year":"1988","unstructured":"Dauber-Osguthorpe, P., Roberts, V.A., Osguthorpe, D.J., Wolff, J., Genest, M. and Hagler, A.T., Proteins: Structure, Function, and Genetics, 4 (1988) 31.","journal-title":"Proteins: Structure, Function, and Genetics"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/bip.360290315","volume":"29","author":"P.K.C. Paul","year":"1990","unstructured":"Paul, P.K.C., Osguthorpe, P.D., Campbell, M.M., Brown, D.W., Kinsman, R.G., Moss, C. and Osguthorpe, D.J., Biopolymers, 29 (1990) 623.","journal-title":"Biopolymers"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-2836(63)80023-6","volume":"7","author":"G.N. Ramachandran","year":"1963","unstructured":"Ramachandran, G.N., Ramakrishnan, C. and Sasisekharan, V., J. Mol. Biol., 7 (1963) 95.","journal-title":"J. Mol. Biol."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1073\/pnas.74.10.4126","volume":"74","author":"S.S. Zimmerman","year":"1977","unstructured":"Zimmerman, S.S. and Scheraga, H.A., Proc. Natl. Acad. Sci. U.S.A., 74 (1977) 4126.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/bip.360220807","volume":"22","author":"P.S. Stern","year":"1983","unstructured":"Stern, P.S., Chorev, M., Goodman, M. and Hagler, A.T., Biopolymers, 22 (1983) 1901.","journal-title":"Biopolymers"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/bip.1968.360061006","volume":"6","author":"C.M. Venkatachalam","year":"1968","unstructured":"Venkatachalam, C.M., Biopolymers, 6 (1968) 1425.","journal-title":"Biopolymers"},{"key":"CR20","first-page":"1","volume":"37","author":"G.D. Rose","year":"1985","unstructured":"Rose, G.D., Gierasch, L.M. and Smith, J.A., Adv. Prot. Chem., 37 (1985) 1.","journal-title":"Adv. Prot. Chem."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0005-2795(73)90143-8","volume":"303","author":"R. Chandrasekaran","year":"1973","unstructured":"Chandrasekaran, R., Lakshminarayanan, A.V., Pandya, U.V. and Ramachandran, G.N., Biochim. Biophys. Acta, 303 (1973) 14.","journal-title":"Biochim. Biophys. Acta"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1021\/ja00803a062","volume":"95","author":"L.L. Reed","year":"1973","unstructured":"Reed, L.L. and Johnson, P.L., J. Am. Chem. Soc., 95 (1973) 7523.","journal-title":"J. Am. Chem. Soc."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0006-291X(89)92708-3","volume":"165","author":"P.K.C. Paul","year":"1989","unstructured":"Paul, P.K.C., Dauber-Osguthorpe, P., Campbell, M.M. and Osguthorpe, D.J., Biochem. Biophys. Res. Comm., 165 (1989) 1051.","journal-title":"Biochem. Biophys. Res. Comm."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00125013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00125013\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00125013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T09:18:21Z","timestamp":1554283101000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00125013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["BF00125013"],"URL":"https:\/\/doi.org\/10.1007\/bf00125013","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,9]]}}}