{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:40:12Z","timestamp":1762864812474},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1978,1,1]],"date-time":"1978-01-01T00:00:00Z","timestamp":252460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molec. Gen. Genet."],"published-print":{"date-parts":[[1978,1]]},"DOI":"10.1007\/bf00267594","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T02:44:03Z","timestamp":1096425843000},"page":"15-29","source":"Crossref","is-referenced-by-count":21,"title":["Isolation of a small DNA fragment carrying the gene for a dihydrofolate reductase from a trimethoprim resistance factor"],"prefix":"10.1007","volume":"164","author":[{"given":"J. Werner","family":"Zolg","sequence":"first","affiliation":[]},{"given":"Urs J.","family":"H\u00e4nggi","sequence":"additional","affiliation":[]},{"given":"Hans G.","family":"Zachau","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF00267594_CR1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1073\/pnas.57.2.321","volume":"57","author":"H.I. Adler","year":"1967","unstructured":"Adler, H.I., Fisher, W.D., Cohen, A., Hardigree, A.A.: Miniature Escherichia coli cells deficient in DNA. Proc. nat. Acad. Sci. (Wash.) 57, 321\u2013326 (1967)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR2","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1016\/S0021-9258(17)33500-7","volume":"251","author":"F.W. Alt","year":"1976","unstructured":"Alt, F.W., Kellems, R.E., Schimke, R.T.: Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. J. biol. Chem. 251, 3063\u20133074 (1976)","journal-title":"J. biol. Chem."},{"key":"BF00267594_CR3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0006-291X(74)90380-5","volume":"58","author":"S.G.B. Amyes","year":"1974","unstructured":"Amyes, S.G.B., Smith, J.T.: R-factor trimethoprim resistance mechanism: An insusceptible target site. Biochem. biophys. Res. Commun. 58, 412\u2013418 (1974)","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF00267594_CR4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1432-1033.1976.tb10055.x","volume":"61","author":"S.G.B. Amyes","year":"1976","unstructured":"Amyes, S.G.B., Smith, J.T.: The purification and properties of the trimethoprim-resistant dihydrofolate reductase mediated by the R-factor R388. Europ. J. Biochem. 61, 597\u2013603 (1976)","journal-title":"Europ. J. Biochem."},{"key":"BF00267594_CR5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1128\/JB.129.1.358-366.1977","volume":"129","author":"H. Avni","year":"1977","unstructured":"Avni, H., Berg, P.E., Markovitz, A.: New mini-ColE1 as a molecular cloning vehicle. J. Bact. 129, 358\u2013366 (1977)","journal-title":"J. Bact."},{"key":"BF00267594_CR6","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/JB.120.2.618-630.1974","volume":"120","author":"P.T. Barth","year":"1974","unstructured":"Barth, P.T., Grinter, N.J.: Comparison of the desoxyribonucleic acid molecular weights and homologies of plasmids conferring linked resistance to streptomycin and sulfonamides. J. Bact. 120, 618\u2013630 (1974)","journal-title":"J. Bact."},{"key":"BF00267594_CR7","first-page":"455","volume-title":"Chromatography of nucleic acids on hydroxyapatite columns. Procedures in nucleic acid research","author":"G. Bernardi","year":"1971","unstructured":"Bernardi, G.: Chromatography of nucleic acids on hydroxyapatite columns. Procedures in nucleic acid research (Cantoni, G.L., Davis, D.R., eds.), Vol. 2, pp. 455\u2013499. New York: Harper and Row, 1971"},{"key":"BF00267594_CR8","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1073\/pnas.71.7.2900","volume":"71","author":"M. Birnstiel","year":"1974","unstructured":"Birnstiel, M., Telford, J., Weinberg, E., Stafford, D.: Isolation and some properties of the genes coding for histone proteins. Proc. nat. Acad. Sci. (Wash.) 71, 2900\u20132904 (1974)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/188231a0","volume":"188","author":"R.L. Blakley","year":"1960","unstructured":"Blakley, R.L.: Crystalline dihydropteroylglutamic acid. Nature (Lond.) 188, 231\u2013232 (1960)","journal-title":"Nature (Lond.)"},{"key":"BF00267594_CR10","first-page":"139","volume-title":"The biochemistry of folic acid and related pteridines","author":"R.L. Blakley","year":"1969","unstructured":"Blakley, R.L.: The biochemistry of folic acid and related pteridines, pp. 139\u2013187. Amsterdam: North-Holland Publishing Co., (1969)"},{"key":"BF00267594_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-1119(77)90000-2","volume":"2","author":"F. Bolivar","year":"1977","unstructured":"Bolivar, F., Rodriguez, R.L., Greene, P.J., Betlach, M.C., Heyneker, H.L., Boyer, H.W.: Construction and characterization of new cloning vehicles. II: A multipurpose cloning system. Gene 2, 95\u2013113 (1977)","journal-title":"Gene"},{"key":"BF00267594_CR12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1432-1033.1974.tb03599.x","volume":"46","author":"W.M. Bonner","year":"1974","unstructured":"Bonner, W.M., Laskey, R.A.: A film detection method for tritiumlabelled proteins and nucleic acids in polyacrylamide gels. Europ. J. Biochem. 46, 83\u201388 (1974)","journal-title":"Europ. J. Biochem."},{"key":"BF00267594_CR13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1017\/S0016672300015640","volume":"25","author":"A.S. Breeze","year":"1975","unstructured":"Breeze, A.S., Sims, P., Stacey, K.A.: Trimethoprim resistant mutants of E. coli K12: preliminary genetic mapping. Genet. Res. (Camb.) 25, 207\u2013214 (1975)","journal-title":"Genet. Res. (Camb.)"},{"key":"BF00267594_CR14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0092-8674(76)90168-9","volume":"7","author":"S.E. Chang","year":"1976","unstructured":"Chang, S.E., Littlefield, J.W.: Elevated dihydrofolate reductase messenger RNA levels in methotrexate-resistant BHK cells. Cell 7, 391\u2013396 (1976)","journal-title":"Cell"},{"key":"BF00267594_CR15","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1073\/pnas.62.4.1159","volume":"62","author":"D.B. Clewell","year":"1969","unstructured":"Clewell, D.B., Helinski, D.R.: Supercoiled circular DNA-protein complex in Escherichia coli: Purification and induced conversion to an open circular DNA form. Proc. nat. Acad. Sci. (Wash.) 62, 1159\u20131166 (1969)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR16","doi-asserted-by":"crossref","unstructured":"Collins, J., Hohn, B.: Cosmids, a new type of plasmid gene-cloning vector which is packageable in vitro in lambda bacteriophage heads. Proc. nat. Acad. Sci. (Wash.) (1978) in press","DOI":"10.1073\/pnas.75.9.4242"},{"key":"BF00267594_CR17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1073\/pnas.70.1.84","volume":"70","author":"S.D. Cosloy","year":"1973","unstructured":"Cosloy, S.D., Oishi, M.: Genetic transformation in Escherichia coli K12. Proc. nat. Acad. Sci. (Wash.) 70, 84\u201387 (1973)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR18","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1099\/00221287-72-2-349","volume":"72","author":"N. Datta","year":"1972","unstructured":"Datta, N., Hedges, R.W.: Trimethoprim resistance conferred by W plasmids in enterobacteriaceae. J. gen. Microbiol. 72, 349\u2013355 (1972)","journal-title":"J. gen. Microbiol."},{"key":"BF00267594_CR19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00267204","volume":"158","author":"G. Dougan","year":"1978","unstructured":"Dougan, G., Saul, M., Warren, G., Sherratt, D.: A functional map of plasmid ColE1. Molec. gen. Genet. 158, 325\u2013327 (1978)","journal-title":"Molec. gen. Genet."},{"key":"BF00267594_CR20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1128\/JB.116.2.885-892.1973","volume":"116","author":"J. Foulds","year":"1973","unstructured":"Foulds, J., Barrett, C.: Characterization of Escherichia coli mutants tolerant to bacteriocin JF246: Two new classes of tolerant mutants. J. Bact. 116, 885\u2013892 (1973)","journal-title":"J. Bact."},{"key":"BF00267594_CR21","series-title":"Methods Mol. Biol.","first-page":"87","volume-title":"The EcoRI restriction endonuclease","author":"P.J. Greene","year":"1974","unstructured":"Greene, P.J., Betlach, M.C., Boyer, H.W., Goodman, H.M.: The EcoRI restriction endonuclease. Methods Mol. Biol. Vol. 7, pp. 87\u2013111 (Wickner, R.B., ed.). New York: M. Dekker (1974)"},{"key":"BF00267594_CR22","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1128\/JB.116.2.1064-1066.1973","volume":"116","author":"P. Guerry","year":"1973","unstructured":"Guerry, P., LeBlanc, D.J., Falkow, S.: General method for the isolation of plasmid desoxyribonucleic acid. J. Bact. 116, 1064\u20131066 (1973)","journal-title":"J. Bact."},{"key":"BF00267594_CR23","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S0021-9258(19)42894-9","volume":"249","author":"U.J. H\u00e4nggi","year":"1974","unstructured":"H\u00e4nggi, U.J., Littlefield, J.W.: Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells. J. biol. Chem. 249, 1390\u20131397 (1974)","journal-title":"J. biol. Chem."},{"key":"BF00267594_CR24","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1016\/S0021-9258(17)33501-9","volume":"251","author":"U.J. H\u00e4nggi","year":"1976","unstructured":"H\u00e4nggi, U.J., Littlefield, J.W.: Altered regulation of the rate of synthesis of dihydrofolate reductase in methotrexate-resistant hamster cells. J. biol. Chem. 251, 3075\u20133080 (1976)","journal-title":"J. biol. Chem."},{"key":"BF00267594_CR25","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1073\/pnas.74.2.702","volume":"74","author":"F. Heffron","year":"1977","unstructured":"Heffron, F., Bedinger, P., Champoux, J.J., Falkow, S.: Deletions affecting the transposition of an antibiotic resistance gene. Proc. nat. Acad. Sci. (Wash.) 74, 702\u2013706 (1977)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0378-1119(77)90035-X","volume":"1","author":"K. Heininger","year":"1977","unstructured":"Heininger, K., H\u00f6rz, W., Zachau, H.G.: Specificity of cleavage by a restriction nuclease from Bacillus subtilis. Gene 1, 291\u2013303 (1977)","journal-title":"Gene"},{"key":"BF00267594_CR27","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1016\/S0021-9258(18)99436-6","volume":"242","author":"H.R. Herschman","year":"1967","unstructured":"Herschman, H.R., Helinksi, D.R.: Purification and characterization of colicin E2 and colicin E3. J. biol. Chem. 242, 5360\u20135368 (1967)","journal-title":"J. biol. Chem."},{"key":"BF00267594_CR28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0005-2787(75)90318-4","volume":"383","author":"G.O. Humphreys","year":"1975","unstructured":"Humphreys, G.O., Willshaw, G.A., Anderson, E.S.: A simple method for the preparation of large quantities of pure plasmid DNA. Biochim. biophys. Acta (Amst.) 383, 457\u2013463 (1975)","journal-title":"Biochim. biophys. Acta (Amst.)"},{"key":"BF00267594_CR29","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0003-9861(73)90579-1","volume":"158","author":"R.C. Jackson","year":"1973","unstructured":"Jackson, R.C., Harrap, K.R.: Studies with a mathematical model of folate metabolism. Arch. Biochem. Biophys. 158, 827\u2013841 (1973)","journal-title":"Arch. Biochem. Biophys."},{"key":"BF00267594_CR30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-9861(73)90048-9","volume":"154","author":"R.C. Jackson","year":"1973","unstructured":"Jackson, R.C., Huennekens, F.M.: Turnover of dihydrofolate reductase in rapidly dividing cells. Arch. Biochem. Biophys. 154, 192\u2013198 (1973)","journal-title":"Arch. Biochem. Biophys."},{"key":"BF00267594_CR31","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1016\/S0021-9258(17)32931-9","volume":"251","author":"R.E. Kellems","year":"1976","unstructured":"Kellems, R.E., Alt, F.W., Schimke, R.T.: Regulation of folate reductase synthesis in sensitive and methotrexate-resistant Sarcoma 180 cells. J. biol. Chem. 251, 6987\u20136993 (1976)","journal-title":"J. biol. Chem."},{"key":"BF00267594_CR32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1432-1033.1977.tb11289.x","volume":"73","author":"K.W. Knopf","year":"1977","unstructured":"Knopf, K.W.: Simple isolation method and assay for T4 DNA ligase and characterization of the purified enzyme. Europ. J. Biochem. 73, 33\u201338 (1977)","journal-title":"Europ. J. Biochem."},{"key":"BF00267594_CR33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1128\/JB.118.1.213-224.1974","volume":"118","author":"A.J. Kool","year":"1974","unstructured":"Kool, A.J., Zeben, M.S., van, Nijkamp, H.J.J.: Identification of messenger ribonucleic acids and proteins synthesized by the bacteriocinogenic factor Clo DF13 in purified minicells of Escherichia coli. J. Bact. 118, 213\u2013224 (1974)","journal-title":"J. Bact."},{"key":"BF00267594_CR34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/JB.120.1.545-548.1974","volume":"120","author":"Y.M. Kupfersztoch-Portnoy","year":"1974","unstructured":"Kupfersztoch-Portnoy, Y.M., Miklos, G.L.G., Helinski, D.R.: Properties of the relaxation complexes of supercoiled desoxyribonucleic acid and protein of the R plasmids R64, R28K, and R6K. J. Bact. 120, 545\u2013548 (1974)","journal-title":"J. Bact."},{"key":"BF00267594_CR35","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"U.K. Laemmli","year":"1970","unstructured":"Laemmli, U.K.: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227, 680\u2013685 (1970)","journal-title":"Nature (Lond.)"},{"key":"BF00267594_CR36","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1128\/JB.119.3.1072-1074.1974","volume":"119","author":"E.M. Lederberg","year":"1974","unstructured":"Lederberg, E.M., Cohen, S.N.: Transformation of Salmonella typhimurium by plasmid desoxyribonucleic acid. J. Bact. 119, 1072\u20131074 (1974)","journal-title":"J. Bact."},{"key":"BF00267594_CR37","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JB.103.3.836-839.1970","volume":"103","author":"S.B. Levy","year":"1970","unstructured":"Levy, S.B.: Resistance of minicells to penicillin lysis: a method of obtaining large quantities of purified minicells. J. Bact. 103, 836\u2013839 (1970)","journal-title":"J. Bact."},{"key":"BF00267594_CR38","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1128\/JB.120.3.1451-1463.1974","volume":"120","author":"S.B. Levy","year":"1974","unstructured":"Levy, S.B.: R factor proteins synthesized in Escherichia coli minicells: incorporation studies with different R factors and detection of desoxyribonucleic acid-binding proteins. J. Bact. 120, 1451\u20131463 (1974)","journal-title":"J. Bact."},{"key":"BF00267594_CR39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1073\/pnas.62.1.88","volume":"62","author":"J.W. Littlefield","year":"1969","unstructured":"Littlefield, J.W.: Hybridization of hamster cells with high and low folate reductase activity. Proc. nat. Acad. Sci. (Wash.) 62, 88\u201395 (1969)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0065-2571(77)90022-X","volume":"15","author":"J.W. Littlefield","year":"1977","unstructured":"Littlefield, J.W., Chang, S.E., H\u00e4nggi, U.J., Nakamura, H., Orkins, S.H.: Studies on the overproduction of didydrofolate reductase by variant hamster cells in culture. Adv. Enzyme Regul. 15, 301\u2013317 (1977)","journal-title":"Adv. Enzyme Regul."},{"key":"BF00267594_CR41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/bj1130013Pa","volume":"113","author":"U.E. Loening","year":"1969","unstructured":"Loening, U.E.: The determination of the molecular weight of ribonucleic acid by polyacrylamide-gel electrophoresis. Biochem. J. 113, 131\u2013138 (1969)","journal-title":"Biochem. J."},{"key":"BF00267594_CR42","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1128\/JB.123.2.768-770.1975","volume":"123","author":"M.S. May","year":"1975","unstructured":"May, M.S., Hattman, S.: Analysis of bacteriophage desoxyribonucleic acid sequences methylated by host-and R-factor-controlled enzymes. J. Bact. 123, 768\u2013770 (1975)","journal-title":"J. Bact."},{"key":"BF00267594_CR43","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(77)90039-3","volume":"10","author":"R.B. Meagher","year":"1977","unstructured":"Meagher, R.B., Tait, R.C., Betlach, M., Boyer, H.W.: Protein expression in E. coli minicells by recombinant plasmids. Cell 10, 521\u2013536 (1977)","journal-title":"Cell"},{"key":"BF00267594_CR44","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1128\/JB.127.3.1529-1537.1976","volume":"127","author":"J.A. Meyers","year":"1976","unstructured":"Meyers, J.A., Sanchez, D., Elwell, L.P., Falkow, S.: Simple agarose gel electrophoretic method for the identification and charaterization of plasmid desoxyribonucleic acid. J. Bact. 127, 1529\u20131537 (1976)","journal-title":"J. Bact."},{"key":"BF00267594_CR45","volume-title":"Experiments in molecular genetics","author":"J.H. Miller","year":"1972","unstructured":"Miller, J.H.: Experiments in molecular genetics. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory 1972"},{"key":"BF00267594_CR46","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/br.40.1.168-189.1976","volume":"40","author":"R.P. Novick","year":"1976","unstructured":"Novick, R.P., Clowes, R.C., Cohen, S.N., Curtiss III, R., Datta, N., Falkow, S.: Uniform nomenclature for bacterial plasmids: a proposal. Bact. Rev 40, 168\u2013189 (1976)","journal-title":"Bact. Rev"},{"key":"BF00267594_CR47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/264193a0","volume":"264","author":"A. Oka","year":"1976","unstructured":"Oka, A., Takanami, M.: Cleavage map of colicin E1 plasmid. Nature (Lond.) 264, 193\u2013196 (1976)","journal-title":"Nature (Lond.)"},{"key":"BF00267594_CR48","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0021-9258(18)64688-5","volume":"233","author":"M.J. Osborn","year":"1958","unstructured":"Osborn, M.J., Huennekens, F.M.: Enzymatic reduction of dihydrofolic acid. J. biol. Chem. 233, 969\u2013974 (1958)","journal-title":"J. biol. Chem."},{"key":"BF00267594_CR49","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1021\/bi00858a033","volume":"6","author":"A.C. Peacock","year":"1967","unstructured":"Peacock, A.C., Dingman, C.W.: Resolution of multiple ribonucleic acid species by polyacrylamide gel electrophoresis. Biochem. 6, 1818\u20131827 (1967)","journal-title":"Biochem."},{"key":"BF00267594_CR50","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/258450a0","volume":"258","author":"W. Pfeiffer","year":"1975","unstructured":"Pfeiffer, W., H\u00f6rz, W., Igo-Kemenes, T., Zachau, H.G.: Restriction nucleases as probes of chromatin structure. Nature (Lond.) 258, 450\u2013452 (1975)","journal-title":"Nature (Lond.)"},{"key":"BF00267594_CR51","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1432-1033.1974.tb03573.x","volume":"45","author":"P. Philippsen","year":"1974","unstructured":"Philippsen, P., Streeck, R.E., Zachau, H.G.: Defined fragments of calf, human, and rat DNA produced by restriction nucleases. Europ. J. Biochem. 45, 479\u2013488 (1974)","journal-title":"Europ. J. Biochem."},{"key":"BF00267594_CR52","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/nar\/3.7.1747","volume":"3","author":"V. Pirrotta","year":"1976","unstructured":"Pirrotta, V.: Two restriction endonucleases from Bacillus globigii. Nucleic Acids Res. 3, 1747\u20131760 (1976)","journal-title":"Nucleic Acids Res."},{"key":"BF00267594_CR53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0022-2836(75)90375-7","volume":"91","author":"R.J. Roberts","year":"1975","unstructured":"Roberts, R.J., Breitmeyer, J.B., Tabachnik, N.F., Myers, P.A.: A second specific endonuclease from Haemophilus aegyptius. J. molec. Biol. 91, 121\u2013123 (1975)","journal-title":"J. molec. Biol."},{"key":"BF00267594_CR54","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0022-2836(76)90079-6","volume":"102","author":"R.J. Roberts","year":"1976","unstructured":"Roberts, R.J., Myers, P.A., Morrison, A., Murray, K.: A specific endonuclease from Arthrobacter luteus. J. molec. Biol. 102, 157\u2013165 (1976a)","journal-title":"J. molec. Biol."},{"key":"BF00267594_CR55","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0022-2836(76)90060-7","volume":"103","author":"R.J. Roberts","year":"1976","unstructured":"Roberts, R.J., Myers, P.A., Morrison, A., Murray, K.: A specific endonuclease from Haemophilus haemolyticus. J. molec. Biol. 103, 199\u2013208 (1976b)","journal-title":"J. molec. Biol."},{"key":"BF00267594_CR56","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/newbio234040a0","volume":"234","author":"R. Rownd","year":"1971","unstructured":"Rownd, R., Mickel, S.: Dissociation and reassociation of RTF and r-determinants of the R-factor NR1 in Proteus mirabilis. Nature (Lond.) New Biol. 234, 40\u201343 (1971)","journal-title":"Nature (Lond.) New Biol."},{"key":"BF00267594_CR57","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1021\/bi00740a018","volume":"12","author":"P.A. Sharp","year":"1973","unstructured":"Sharp, P.A., Sugden, B., Sambrook, J.: Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose ethidium bromide electrophoresis. Biochem. 12, 3055\u20133063 (1973)","journal-title":"Biochem."},{"key":"BF00267594_CR58","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00337941","volume":"147","author":"R. Sheldon","year":"1976","unstructured":"Sheldon, R., Brenner, S.: Regulatory mutants of dihydrofolate reductase in Escherichia coli K12. Molec. gen. Genet. 147, 91\u201397 (1976)","journal-title":"Molec. gen. Genet."},{"key":"BF00267594_CR59","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/genetics\/65.3.391","volume":"65","author":"F.M. Sirotnak","year":"1970","unstructured":"Sirotnak, F.M.: Increased dihydrofolate reductase synthesis in Diplococcus pneumoniae following translatable alteration of the structural gene. III. Further evidence on the extent of genetic involvement. Genetics 65, 391\u2013406 (1970)","journal-title":"Genetics"},{"key":"BF00267594_CR60","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/genetics\/74.4.543","volume":"74","author":"F.M. Sirotnak","year":"1973","unstructured":"Sirotnak, F.M., McCuen, R.W.: Hyperproduction of dihydrofolate reductase in Diplococcus pneumoniae after mutation in the structural gene. Evidence for an effect at the level of transcription. Genetics 74, 543\u2013556 (1973)","journal-title":"Genetics"},{"key":"BF00267594_CR61","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0022-2836(73)90152-6","volume":"81","author":"H.O. Smith","year":"1973","unstructured":"Smith, H.O., Nathans, D.: A suggested nomenclature for bacterial host modification and restriction systems and their enzymes. J. molec. Biol. 81, 419\u2013423 (1973)","journal-title":"J. molec. Biol."},{"key":"BF00267594_CR62","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00425649","volume":"142","author":"M. So","year":"1975","unstructured":"So, M., Gill, R., Falkow, S.: The generation of a ColE1-Apr cloning vehicle which allows detection of inserted DNA. Molec. gen. Genet. 142, 239\u2013249 (1975)","journal-title":"Molec. gen. Genet."},{"key":"BF00267594_CR63","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1073\/pnas.74.8.3480","volume":"74","author":"D.A. Spandidos","year":"1977","unstructured":"Spandidos, D.A., Siminovitch, L.: Transfer of codominant markers by isolated metaphase chromosomes in Chinese hamster ovary cells. Proc. nat. Acad. Sci. (Wash.) 74, 3480\u20133484 (1977)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR64","doi-asserted-by":"crossref","unstructured":"Streeck, R.W., Zachau, H.G.: A long range and two short range periodicities are superimposed in the 1.706 satellite DNA from calf thymus. Europ. J. Biochem. (1978) in press","DOI":"10.1111\/j.1432-1033.1978.tb20923.x"},{"key":"BF00267594_CR65","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/JB.121.1.354-362.1975","volume":"121","author":"T. Tanaka","year":"1975","unstructured":"Tanaka, T., Weisblum, B.: Construction of a colicin E1 R-factor composite plasmid in vitro: means for amplification of desoxyribonucleic acid. J. Bact. 121, 354\u2013362 (1975)","journal-title":"J. Bact."},{"key":"BF00267594_CR66","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0003-2697(75)90739-3","volume":"66","author":"R.W.J. Thuring","year":"1975","unstructured":"Thuring, R.W.J., Sanders, J.P.M., Borst, P.: A freeze-squeeze method for recovering long DNA from agarose gels. Analyt. Biochem. 66, 213\u2013220 (1975)","journal-title":"Analyt. Biochem."},{"key":"BF00267594_CR67","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1073\/pnas.69.7.1659","volume":"69","author":"R.B. Trimble","year":"1972","unstructured":"Trimble, R.B., Galivan, J., Maley, F.: The temporal expression of T2r+ bacteriophage genes in vivo and in vitro. Proc. nat. Acad. Sci. (Wash.) 69, 1659\u20131663 (1972)","journal-title":"Proc. nat. Acad. Sci. (Wash.)"},{"key":"BF00267594_CR68","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1016\/S0021-9258(18)93227-8","volume":"243","author":"B. Weiss","year":"1968","unstructured":"Weiss, B., Jacquemin-Sablon, A., Live, T.R., Fareed, G.C., Richardson, C.C.: Enzymatic breakage and joining of desoxyribonucleic acid. J. biol. Chem. 243, 4543\u20134555 (1968)","journal-title":"J. biol. Chem."},{"key":"BF00267594_CR69","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0022-2836(72)90342-7","volume":"71","author":"A. Worcel","year":"1972","unstructured":"Worcel, A., Burgi, E.: On the structure of the folded chromosome of Escherichia coli. J. molec. Biol. 71, 127\u2013147 (1972)","journal-title":"J. molec. Biol."},{"key":"BF00267594_CR70","unstructured":"Yoshimori, R.N.: A genetic and biochemical analysis of the restrictic and modification of DNA by resistance transfer factors. Thesis Univ. of Calif., San Francisco (1971)"},{"key":"BF00267594_CR71","unstructured":"Zolg, J.W.: Isolierung und Charakterisierung des Gens f\u00fcr eine Trimethoprim-resistente Dihydrofolatreduktase aus dem R-Faktor R388. Thesis Univ. of Munich, Munich (1978)"},{"key":"BF00267594_CR72","first-page":"1306","volume":"358","author":"J.W. Zolg","year":"1977","unstructured":"Zolg, J.W., H\u00e4nggi, U.J.: Production of increased levels of dihydrofolate reductase by amplification of the reductase gene. Hoppe-Seylers Z. physiol Chemie 358, 1306 (1977)","journal-title":"Hoppe-Seylers Z. physiol Chemie"}],"container-title":["Molecular and General Genetics MGG"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00267594.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00267594\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00267594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00267594.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T01:15:06Z","timestamp":1624670106000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00267594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,1]]}},"alternative-id":["BF00267594"],"URL":"https:\/\/doi.org\/10.1007\/bf00267594","relation":{},"ISSN":["0026-8925","1432-1874"],"issn-type":[{"value":"0026-8925","type":"print"},{"value":"1432-1874","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}