{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T23:16:49Z","timestamp":1699658209440},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1979,1,1]],"date-time":"1979-01-01T00:00:00Z","timestamp":283996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch. Pharmacol."],"published-print":{"date-parts":[[1979]]},"DOI":"10.1007\/bf00504753","type":"journal-article","created":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T03:30:28Z","timestamp":1100662228000},"page":"217-224","source":"Crossref","is-referenced-by-count":36,"title":["Effects of ring substitution on the pre- and postjunctional alpha-adrenergic activity of aryliminoimidazolidines"],"prefix":"10.1007","volume":"309","author":[{"given":"J. Paul","family":"Hieble","sequence":"first","affiliation":[]},{"given":"Robert G.","family":"Pendleton","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0024-3205(77)90066-2","volume":"21","author":"S. Berthelsen","year":"1977","unstructured":"Berthelsen, S., Pettinger, W. A.: A functional basis for classification of ?-adrenergic receptors. Life Sci. 21, 595?606 (1977)","journal-title":"Life Sci."},{"key":"CR2","first-page":"221","volume":"151","author":"J. R. Blinks","year":"1966","unstructured":"Blinks, J. R.: Field stimulation as a means of effecting the graded release of autonomic transmitters in isolated heart muscle. J. Pharmacol. Exp. Ther. 151, 221?235 (1966)","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CR3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0014-2999(68)90167-2","volume":"4","author":"J. W. Constantine","year":"1968","unstructured":"Constantine, J. W., McShane, W. K.: Analysis of the cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (Catapress). Eur. J. Pharmacol. 4, 109?123 (1968)","journal-title":"Eur. J. Pharmacol."},{"key":"CR4","first-page":"431","volume":"190","author":"L. X. Cubeddu","year":"1974","unstructured":"Cubeddu, L. X., Barnes, E. M., Langer, S. Z., Weiner, N.: Release of norepinephrine and dopamine ?-hydroxylase by nerve stimulation. 1. Role of neuronal and extraneuronal uptake and of ?-presynaptic receptors. J. Pharmacol. Exp. Ther. 190, 431?450 (1974)","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CR5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1476-5381.1977.tb16752.x","volume":"60","author":"J. C. Doxey","year":"1977","unstructured":"Doxey, J. C., Smith, C. F. C., Walker, J. M.: Selectivity of blocking agents for pre- and postsynaptic ?-adrenoceptors. Br. J. Pharmacol. 60, 91?96 (1977)","journal-title":"Br. J. Pharmacol."},{"key":"CR6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(76)90084-4","volume":"36","author":"G. M. Drew","year":"1976","unstructured":"Drew, G. M.: Effects of ?-adrenoceptor agonists and antagonists on pre- and postsynaptically located ?-adrenoceptors. Eur. J. Pharmacol. 36, 313?320 (1976)","journal-title":"Eur. J. Pharmacol."},{"key":"CR7","first-page":"283","volume-title":"Handbook of Experimental Pharmacology ? New Series","author":"R. F. Furchgott","year":"1972","unstructured":"Furchgott, R. F.: The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In: Handbook of Experimental Pharmacology ? New Series, pp. 283?335. (O. Eichler, A. Farah, H. Herken and A. D. Welch, ed.). Berlin, Heidelberg, New York: Springer 1972"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00505086","volume":"295","author":"G. Haeusler","year":"1976","unstructured":"Haeusler, G.: Studies on the possible contribution of a peripheral presynaptic action of clonidine and dopamine to their vascular effects under in vivo conditions. Naunyn-Schmiedeberg's Arch. Pharmacol. 295, 191?202 (1976)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/icb.1972.44","volume":"50","author":"R. L. Hodge","year":"1972","unstructured":"Hodge, R. L., Robinson, S. M.: The action of clonidine on isolated arterial preparations. Aust. J. Exp. Biol. Med. Sci. 50, 517?526 (1972)","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"CR10","first-page":"786","volume":"25","author":"W. Hoefke","year":"1975","unstructured":"Hoefke, W., Kobinger, W., Walland, A.: Relationship between activity and structure in derivatives of clonidine. Arzneim.-Forsch. 25, 786?793 (1975)","journal-title":"Arzneim.-Forsch."},{"key":"CR11","first-page":"1","volume":"14","author":"C. S. Hooker","year":"1977","unstructured":"Hooker, C. S., Calkins, P. J., Fleisch, J. H.: On the measurement of vascular and respiratory smooth muscle responses in vitro. Blood Vessels 14, 1?11 (1977)","journal-title":"Blood Vessels"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1476-5381.1972.tb07285.x","volume":"44","author":"J. Hughes","year":"1972","unstructured":"Hughes, J.: Evaluation of machanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens. Br. J. Pharmacol. 44, 472?491 (1972)","journal-title":"Br. J. Pharmacol."},{"key":"CR13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/oxfordjournals.bmb.a070982","volume":"29","author":"L. L. Iversen","year":"1973","unstructured":"Iversen, L. L.: Catecholamine uptake processes. Br. Med. Bull. 29, 130?135 (1973)","journal-title":"Br. Med. Bull."},{"key":"CR14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1021\/jm00235a020","volume":"18","author":"T. Jen","year":"1975","unstructured":"Jen, T., Van Hoeven, H., Groves, W., McLean, R. A., Loev, B.: Amidines and related compounds. 6. Studies on structure-activity relationships of antihypertensive and antisecretory agents related to clonidine. J. Med. Chem. 18, 90?99 (1975)","journal-title":"J. Med. Chem."},{"key":"CR15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BFb0034091","volume":"81","author":"W. Kobinger","year":"1978","unstructured":"Kobinger, W.: Central ?-adrenergic systems as targets for hypotensive drugs. Rev. Physiol. Biochem. Pharmacol. 81, 39?100 (1978)","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"CR16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1476-5381.1977.tb07526.x","volume":"60","author":"S. Z. Langer","year":"1977","unstructured":"Langer, S. Z.: Presynaptic receptors and their role in the regulation of transmitter release. Br. J. Pharmacol. 60, 481?497 (1977)","journal-title":"Br. J. Pharmacol."},{"key":"CR17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00507961","volume":"304","author":"I. C. Medgett","year":"1978","unstructured":"Medgett, I. C., McCulloch, M. W., Rand, N. J.: Partial agonist action of clonidine on prejunctional and postjunctional ?-adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 304, 215?221 (1978)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0014-2999(78)90281-9","volume":"52","author":"L. Pichler","year":"1978","unstructured":"Pichler, L., Kobinger, W.: Presynaptic activity at peripheral adrenergic sites and blood pressure effect of ?-adrenoceptor stimulating drugs. Eur. J. Pharmacol. 52, 287?295 (1978)","journal-title":"Eur. J. Pharmacol."},{"key":"CR19","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1021\/jm00230a014","volume":"19","author":"B. Rouot","year":"1976","unstructured":"Rouot, B., Leclerc, G., Wermuth, C. G., Miesch, F., Schwarz, J.: Clonidine and related analogues. Quantitative correlations. J. Med. Chem. 19, 1049?1054 (1976)","journal-title":"J. Med. Chem."},{"key":"CR20","first-page":"335","volume":"16","author":"P. A. Shore","year":"1957","unstructured":"Shore, P. A., Olin, J. S., Brodie, B. B.: Release of brain norepinephrine by reserpine. Fed. Proc. 16, 335?336 (1957)","journal-title":"Fed. Proc."},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0050157","volume":"77","author":"K. Starke","year":"1977","unstructured":"Starke, K.: Regulation of noradrenaline release by presynaptic receptor systems. Rev. Physiol. Biochem. Pharmacol. 77, 1?124 (1977)","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"CR22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00501149","volume":"285","author":"K. Starke","year":"1974","unstructured":"Starke, K., Montel, H., Gayk, W., Merker, R.: Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 285, 133?150 (1974)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00510821","volume":"291","author":"K. Starke","year":"1975","unstructured":"Starke, K., Endo, T., Taube H. D.: Relative pre- and postsynaptic potencies of ?-adrenoceptor agonists in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol. 291, 55?78 (1975)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR24","first-page":"266","volume":"35","author":"O. S. Steinsland","year":"1976","unstructured":"Steinsland, O. S., Hieble, J. P.: Further characterization of the prejunctional ?-adrenergic and dopaminergic receptors of the rabbit ear artery. Fed. Proc. 35, 266 (1976)","journal-title":"Fed. Proc."},{"key":"CR25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1126\/science.22933","volume":"199","author":"O. S. Steinsland","year":"1978","unstructured":"Steinsland, O. S., Hieble, J. P.: Dopaminergic inhibition of adrenergic neurotransmission as a model for studies on dopamine receptor mechanisms. Science 199, 443?445 (1978)","journal-title":"Science"},{"key":"CR26","first-page":"378","volume":"12","author":"O. S. Steinsland","year":"1975","unstructured":"Steinsland, O. S., Nelson, S. H.: Alpha-adrenergic' inhibition of the response of the isolated rabbit ear artery to brief intermittent sympathetic nerve stimulation. Blood Vessels 12, 378?379 (1975)","journal-title":"Blood Vessels"},{"key":"CR27","first-page":"346","volume":"184","author":"O. S. Steinsland","year":"1973","unstructured":"Steinsland, O. S., Furchgott, R. F., Kirkpekar, S. M.: Inhibition of adrenergic neurotransmission by parasympathomimetics in the rabbit ear artery. J. Pharmacol. Exp. Ther. 184, 346?356 (1973)","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"CR28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00507962","volume":"304","author":"A. Steppeler","year":"1978","unstructured":"Steppeler, A., Tanaka, T., Starke, K.: A comparison of pre- and postsynaptic ?-adrenergic effects of phenylephrine and tramazoline on blood vessels of the rabbit in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 304, 223?230 (1978)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR29","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0024-3205(75)90487-7","volume":"17","author":"H. Struyker Boudier","year":"1975","unstructured":"Struyker Boudier, H., de Boer, J., Smeets, G., Lien, E. J., van Rossum, J.: Structure activity relationships for central and peripheral ?-adrenergic activities of imidazoline derivatives. Life Sci. 17, 377?386 (1975a)","journal-title":"Life Sci."},{"key":"CR30","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.2042-7158.1975.tb10240.x","volume":"27","author":"H. Struyker Boudier","year":"1975","unstructured":"Struyker Boudier, H., Teppema, L., Cools, A., van Rossum, J.: (3,4-Dihydroxyphenylamino)-2-imidazoline (DPI), a new potent agonist at dopamine receptors mediating neuronal inhibition. J. Pharm. Pharmacol. 27, 882?883 (1975b)","journal-title":"J. Pharm. Pharmacol."},{"key":"CR31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.pc.09.100158.001443","volume":"9","author":"R. W. Taft","year":"1958","unstructured":"Taft, R. W., Deno, N. C., Skell, P. S.: Physical Organic Chemistry. Ann. Rev. Phys. Chem. 9, 287?314 (1958)","journal-title":"Ann. Rev. Phys. Chem."},{"key":"CR32","first-page":"237","volume":"228","author":"P. B. M. W. M. Timmermans","year":"1977","unstructured":"Timmermans, P. B. M. W. M., van Zwieten, P. A.: Hypotensive and bradycardic activities of clonidine and related imidazolidines; structure activity relationship. Arch. Int. Pharmacodyn. Ther. 228, 237?250 (1977a)","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"CR33","first-page":"251","volume":"228","author":"P. B. M. W. M. Timmermans","year":"1977","unstructured":"Timmermans, P. B. M. W. M., van Zwieten, P. A.: Central hypotensive and antihypertensive activities of imidazolidines, structurally related to clonidine. Arch. Int. Pharmacodyn. Ther. 228, 251?267 (1977b)","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"CR34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-2999(77)90003-6","volume":"45","author":"P. B. M. W. M. Timmermans","year":"1977","unstructured":"Timmermans, P. B. M. W. M., van Zwieten, P. A.: Central and peripheral ?-adrenergic effects of some imidazolidines. Eur. J. Pharmacol. 45, 229?236 (1977c)","journal-title":"Eur. J. Pharmacol."},{"key":"CR35","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1021\/jm00222a020","volume":"20","author":"P. B. M. W. M. Timmermans","year":"1977","unstructured":"Timmermans, P. B. M. W. M., van Zwieten, P. A.: Quantitative structure-activity relationships in centrally acting imidazolidines structurally related to clonidine. J. Med. Chem. 20, 1636?1644 (1977d)","journal-title":"J. Med. Chem."},{"key":"CR36","first-page":"1676","volume":"28","author":"P. B. M. W. M. Timmermans","year":"1978","unstructured":"Timmermans, P. B. M. W. M., van Zwieten, P. A.: Dissociation constants of clonidine and structurally related imidazolidines. Arzneim. Forsch. 28, 1676?1681 (1978)","journal-title":"Arzneim. Forsch."},{"key":"CR37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00500963","volume":"300","author":"P. B. M. W. M. Timmermans","year":"1977","unstructured":"Timmermans, P. B. M. W. M., Brands, A., van Zwieten, P. A.: Lipophilicity and brain disposition of clonidine and structurally related imidazolidines. Naunyn-Schmiedeberg's Arch. Pharmacol. 300, 217?226 (1977a)","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"CR38","first-page":"2266","volume":"27","author":"P. B. M. W. M. Timmermans","year":"1977","unstructured":"Timmermans, P. B. M. W. M., van Zwieten, P. A., Meerman-van Benthem, C. M., van der Meer, K., Mulder, J. J. C.: Quantum chemical studies on clonidine and related derivatives. Arzneim-Forsch. 27, 2266?2270 (1977b)","journal-title":"Arzneim-Forsch."},{"key":"CR39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-2999(78)90392-8","volume":"47","author":"A. Walland","year":"1978","unstructured":"Walland, A.: Inhibition of a somato-sympathetic reflex via peripheral presynaptic ?-adrenoceptors. Eur. J. Pharmacol. 47, 211?221 (1978)","journal-title":"Eur. J. Pharmacol."},{"key":"CR40","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/273164a0","volume":"273","author":"J. E. S. Wikberg","year":"1978","unstructured":"Wikberg, J. E. S.: Pharmacological classification of adrenergic receptors in the guinea pig. Nature 273, 164?166 (1978)","journal-title":"Nature"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00504753.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF00504753\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF00504753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T14:15:48Z","timestamp":1554387348000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF00504753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979]]}},"alternative-id":["BF00504753"],"URL":"https:\/\/doi.org\/10.1007\/bf00504753","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979]]}}}