{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:55:40Z","timestamp":1772142940442,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1987,4,1]],"date-time":"1987-04-01T00:00:00Z","timestamp":544233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Computer-Aided Mol Des"],"published-print":{"date-parts":[[1987,4]]},"DOI":"10.1007\/bf01680553","type":"journal-article","created":{"date-parts":[[2005,5,13]],"date-time":"2005-05-13T15:32:12Z","timestamp":1115998332000},"page":"3-16","source":"Crossref","is-referenced-by-count":139,"title":["A unique geometry of the active site of angiotensin-converting enzyme consistent with structure-activity studies"],"prefix":"10.1007","volume":"1","author":[{"given":"Dorica","family":"Mayer","sequence":"first","affiliation":[]},{"given":"Christopher B.","family":"Naylor","sequence":"additional","affiliation":[]},{"given":"Ioan","family":"Motoc","sequence":"additional","affiliation":[]},{"given":"Garland R.","family":"Marshall","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF01680553_CR1","doi-asserted-by":"crossref","unstructured":"Marshall, G.R., Barry, C.D., Bosshard, H.E., Dammkochler, R.A. and Dunn, D.A., In Olson, E.C. and Christoffersen, R.E. (Eds) Computer-assisted Drug Design, Washington, DC, ACS Symposium 112, 1979, pp. 205\u2013226.","DOI":"10.1021\/bk-1979-0112.ch009"},{"key":"BF01680553_CR2","first-page":"115","volume-title":"Molecular Graphics and Drug Design","author":"G.R. Marshall","year":"1986","unstructured":"Marshall, G.R. and Motoc, I., In Burgen, A.S.V., Roberts, G.C.K. and Tute, M.S. (Eds) Molecular Graphics and Drug Design, Elsevier, Amsterdam, 1986, pp. 115\u2013156."},{"key":"BF01680553_CR3","first-page":"1","volume-title":"The Enzymes","author":"J.A. Hartsuck","year":"1971","unstructured":"Hartsuck, J.A. and Lipscomb, W.N., In Boyer, P.D. (Ed) The Enzymes, Academic Press, New York, 1971, Vol 3 pp. 1\u201356."},{"key":"BF01680553_CR4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0022-2836(76)90058-9","volume":"103","author":"M.E. Schmid","year":"1976","unstructured":"Schmid, M.E. and Herriott, J.R., J. Mol. Biol. 103 (1976) pp. 175\u2013190.","journal-title":"J. Mol. Biol."},{"key":"BF01680553_CR5","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1016\/S0021-9258(19)42067-X","volume":"249","author":"B.W. Matthews","year":"1974","unstructured":"Matthews, B.W., Weaver, L.H. and Kestov, W.R., J. Biol. Chem., 249 (1974) 8030\u20138044.","journal-title":"J. Biol. Chem."},{"key":"BF01680553_CR6","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","volume":"20","author":"D.W. Cushman","year":"1971","unstructured":"Cushman, D.W. and Cheung, H.S., Biochem. Pharmacol., 20 (1971) 1637\u20131648.","journal-title":"Biochem. Pharmacol."},{"key":"BF01680553_CR7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0079-6468(08)70157-7","volume":"17","author":"D.W. Cushman","year":"1980","unstructured":"Cushman, D.W. and Ondetti, M.A., Prog. Med. Chem., 17 (1980) 41\u2013104.","journal-title":"Prog. Med. Chem."},{"key":"BF01680553_CR8","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1021\/bi00798a004","volume":"10","author":"M.A. Ondetti","year":"1971","unstructured":"Ondetti, M.A., Williams, N.J., Sabo, E.F., Pluscec, J., Weaver, E.R. and Kocy, O., Biochemistry, 10 (1971) 4033\u20134039.","journal-title":"Biochemistry"},{"key":"BF01680553_CR9","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1021\/bi00644a014","volume":"16","author":"D.W. Cushman","year":"1977","unstructured":"Cushman, D.W., Cheung, H.S., Sabo, E.F. and Ondetti, M.A., Biochemistry, 16 (1977) 5484\u20135491.","journal-title":"Biochemistry"},{"key":"BF01680553_CR10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.191908","volume":"196","author":"M.A. Ondetti","year":"1977","unstructured":"Ondetti, M.A., Rubin, B. and Cushman, D.W., Science, 196 (1977) 441\u2013444.","journal-title":"Science"},{"key":"BF01680553_CR11","unstructured":"Suh, J.T., Skiles, J.W., Williams, B.E. and Schwab, A., U.S. Patents 4, 256, 761 and 4, 304, 771, 1981."},{"key":"BF01680553_CR12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0014-5793(82)81036-3","volume":"147","author":"C.H. Hassall","year":"1982","unstructured":"Hassall, C.H., Krohn, A., Moody, C.J. and Thomas, W.A., FEBS Lett., 147 (1982) 175\u2013179.","journal-title":"FEBS Lett."},{"key":"BF01680553_CR13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/01.HYP.1.1.39","volume":"1","author":"E.L. Bravo","year":"1979","unstructured":"Bravo, E.L. and Tarazi, R.C., Hypertension, 1 (1979) 39\u201346.","journal-title":"Hypertension"},{"key":"BF01680553_CR14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/10409238409108720","volume":"16","author":"M.A. Ondetti","year":"1984","unstructured":"Ondetti, M.A. and Cushman, D.W., Crit. Rev. Biochem., 16 (1984) 381\u2013411.","journal-title":"Crit. Rev. Biochem."},{"key":"BF01680553_CR15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/jm00357a013","volume":"26","author":"F.J. McEvoy","year":"1983","unstructured":"McEvoy, F.J., Lai, F.M. and Albright, J.D., J. Med. Chem., 26 (1983) 381\u2013393.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0006-291X(83)80131-4","volume":"111","author":"E.D. Thorsett","year":"1983","unstructured":"Thorsett, E.D., Harris, E.E., Aster S., Peterson, E.R., Taub, D. and Patchett, A.A., Biochem. Biophys. Res. Commun., 111 (1983) 166\u2013171.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF01680553_CR17","unstructured":"Krohn, A., In Emmet, J.C. (Ed) Second SCI-RSC Medicinal Chem. Symp., 1984, pp. 109\u2013123."},{"key":"BF01680553_CR18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1039\/P19840000155","volume":"1","author":"C.H. Hassall","year":"1984","unstructured":"Hassall, C.H., Krohn, A., Moody, C.J. and Thomas, W.A., J. Chem. Soc. Perkin Trans., 1 (1984) 155\u2013164.","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"BF01680553_CR19","doi-asserted-by":"crossref","first-page":"5777","DOI":"10.1021\/bi00266a008","volume":"21","author":"R.E. Galardy","year":"1982","unstructured":"Galardy, R.E., Biochemistry, 21 (1982) 5777\u20135781.","journal-title":"Biochemistry"},{"key":"BF01680553_CR20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1021\/jm00153a017","volume":"29","author":"R. Ciabatti","year":"1986","unstructured":"Ciabatti, R., Padova, G., Bellasio, E., Tarzia, G., Depaoli, A., Battaglia, F., Cellentani, M., Barone, D. and Baldoli, E., J. Med. Chem., 29 (1986) 411\u2013417.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1021\/jm00357a014","volume":"26","author":"D.H. Kim","year":"1983","unstructured":"Kim, D.H., Guinosso, C.J., Buzby, G.C. Jr., Herbst, D.R., McCaully, R.J., Wicks, T.C. and Wendt, R.L., J. Med. Chem., 26 (1983) 394\u2013403.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR22","unstructured":"Wyvratt, M.J., Tischler, M.H., Ikeler, T.J., Springer, J.P., Tristram, E.W. and Patchett, A.A., In Hruby, V.J. and Rich, D.H. (Eds) Peptides: Structure and Function. Proc. 8th Am. Peptide Symp., Pierce Chemical Company, Rockford, Illinois, 1983, pp 551\u2013554."},{"key":"BF01680553_CR23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/jm00382a008","volume":"28","author":"W.J. Greenlee","year":"1985","unstructured":"Greenlee, W.J., Allibone, P.L., Perlow, D.S., Patchett, A.A., Ulm, E.H. and Vassil, T.C., J. Med. Chem., 28 (1985) 434\u2013442.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR24","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/bi00277a039","volume":"22","author":"R.E. Galardy","year":"1983","unstructured":"Galardy, R.E., Kontoyiannidou-Ostrem, V. and Kortylewicz, Z.P., Biochemistry, 22 (1983) 1990\u20131995.","journal-title":"Biochemistry"},{"key":"BF01680553_CR25","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1021\/jm00363a012","volume":"26","author":"N. Gruenfeld","year":"1983","unstructured":"Gruenfeld, N., Stanton, J.L., Yuan, A.M., Ebetino, F.H., Browne, L.J., Gude, C and Huebner, C.F., J. Med. Chem., 26 (1983) 1277\u20131282.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR26","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1021\/jm00155a032","volume":"29","author":"J.W. Skiles","year":"1986","unstructured":"Skiles, J.W., Suh, J.T., Williams, B.E., Menard, P.R., Barton, J.N., Jones, H., Neiss, E.S., Schwab, A., Mann, W.S., Khandwala, A., Wolf, P.S., and Weinryb, I., J. Med. Chem., 29, (1986) 784\u2013796.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/med.2610020103","volume":"2","author":"E.W. Petrillo Jr.","year":"1982","unstructured":"Petrillo, E.W., Jr. and Ondetti, M.A., Med. Res. Rev., 2 (1982) 1\u201341.","journal-title":"Med. Res. Rev."},{"key":"BF01680553_CR28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/jm00381a021","volume":"28","author":"P.R. Andrews","year":"1985","unstructured":"Andrews, P.R., Carson, J.M., Caselli, A., Spark, M.J. and Woods, R., J. Med. Chem., 28 (1985) 393\u2013399.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1021\/jm00152a014","volume":"29","author":"E.D. Thorsett","year":"1986","unstructured":"Thorsett, E.D., Harris, E.E., Aster, S.D., Peterson, E.R., Snyder, J.P., Springer, J.P., Hirshfield, J., Tristram, E.W., Patchett, A.A., Ulm, E.H. and Vassil, T.C., J. Med. Chem., 29 (1986) 251\u2013260.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR30","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1021\/jm00148a008","volume":"28","author":"R.E. Galardy","year":"1985","unstructured":"Galardy, R.E. and Grobelny, D., J. Med. Chem., 28 (1985) 1422\u20131427.","journal-title":"J. Med. Chem."},{"key":"BF01680553_CR31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/med.2610050405","volume":"5","author":"M.J. Wyvratt","year":"1985","unstructured":"Wyvratt, M.J. and Patchett, A.A., Med. Res. Rev., 5 (1985) 483\u2013531.","journal-title":"Med. Res. Rev."},{"key":"BF01680553_CR32","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/288280a0","volume":"288","author":"A.A. Patchett","year":"1980","unstructured":"Patchett, A.A., Harris, E., Tristram, E.W., Wyvratt, M.J., Wu, M.T., Taub, D., Peterson, E.R., Ikeler, T.J., ten Broeke, J., Payne, L.G., Ondeyka, D.L., Thorsett, E.D., Greenlee, W.J., Lohr, N.S., Hoffsommer, R.D., Joshua, H., Ruyle, W.V., Rothrock, J.W., Aster, S.D., Maycock, A.L., Robinson, F.M., Hirschmann, R., Sweet, C.S., Ulm, E.H., Gross, D.M., Vassil, T.C. and Stone C.A., Nature, 288 (1980) 280\u2013283.","journal-title":"Nature"},{"key":"BF01680553_CR33","unstructured":"Kennard, O. and Watson, D.G., (Eds) Molecular Structures and Dimensions, Vol. 3, Bibliography 1969\u20131971, Organic and Organometallic Crystal Structures, N.V.A. Oosthoek's Uitgevers Mij. Utrecht, 1971."},{"key":"BF01680553_CR34","unstructured":"SYBYL. Molecular modeling system. Tripos Associates, St. Louis, Missouri."},{"key":"BF01680553_CR35","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF02158433","volume":"16","author":"W. Klyne","year":"1960","unstructured":"Klyne, W. and Prelog, V., Experientia, 16 (1960) 521\u2013523.","journal-title":"Experientia"},{"key":"BF01680553_CR36","first-page":"222","volume-title":"Mathematical and Computational Concepts in Chemistry","author":"I. Motoc","year":"1986","unstructured":"Motoc, I., Dammkoehler, R.A. and Marshall, G.R., In Trinajstic, N. (Ed) Mathematical and Computational Concepts in Chemistry, Ellis Horwood Ltd., Chichester, 1986, pp. 222\u2013251."},{"key":"BF01680553_CR37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/qsar.19860050305","volume":"5","author":"I. Motoc","year":"1986","unstructured":"Motoc, I., Dammkoehler, R.A., Mayer, D. and Labanowski, J., Quant. Struct.-Act. Relat., 5 (1986) 99\u2013105.","journal-title":"Quant. Struct.-Act. Relat."},{"key":"BF01680553_CR38","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/qsar.19860050403","volume":"5","author":"J. Labanowski","year":"1986","unstructured":"Labanowski, J., Motoc, I., Naylor, C.B., Mayer, D. and Dammkoehler, R.A., Quant. Struct.-Act. Relat., 5 (1986) 138\u2013152.","journal-title":"Quant. Struct.-Act. Relat."},{"key":"BF01680553_CR39","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1073\/pnas.80.11.3178","volume":"80","author":"B.P. Roques","year":"1983","unstructured":"Roques, B.P., Lucas-Soroca, E., Chaillet, P., Costentin, J. and Fournie-Zaluski, M.C., Proc. Natl. Acad. Sci. U.S.A., 80 (1983) 3178\u20133182.","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"BF01680553_CR40","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1021\/jm00345a011","volume":"25","author":"M.E. Condon","year":"1982","unstructured":"Condon, M.E., Petrillo E.W., Jr., Ryono, D.E., Reid, J.A., Neubeck, R., Puar, M., Heikes, J.E., Sabo, E.F., Losee, K.A., Cushman, D.W. and Ondetii, M.A., J. Med. Chem. 25 (1982) 250\u2013258.","journal-title":"J. Med. Chem."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01680553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01680553\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01680553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T23:04:51Z","timestamp":1625958291000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01680553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["BF01680553"],"URL":"https:\/\/doi.org\/10.1007\/bf01680553","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}