{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:02:40Z","timestamp":1770969760388,"version":"3.50.1"},"reference-count":135,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1975,3,1]],"date-time":"1975-03-01T00:00:00Z","timestamp":162864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[1975,3]]},"DOI":"10.1007\/bf01732178","type":"journal-article","created":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T04:08:29Z","timestamp":1118635709000},"page":"1-57","source":"Crossref","is-referenced-by-count":93,"title":["The appearance of new structures and functions in proteins during evolution"],"prefix":"10.1007","volume":"7","author":[{"given":"Emile","family":"Zuckerkandl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01732178_CR1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0005-2728(69)90094-2","volume":"172","author":"C.A. Appleby","year":"1969","unstructured":"Appleby, C.A. (1969). Biochim.Biophys.Acta 172, 88","journal-title":"Biochim.Biophys.Acta"},{"key":"BF01732178_CR2","volume-title":"International Symposium on Protein Synthesis and Nucleic Acids, Proc.XI Latin Am.Symp., La Plata 1971","author":"J.T. August","year":"1972","unstructured":"August, J.T., Eoyang, L., Franze de Fernandez, M.T., Hayward, W.S., Kuo, C.H., Silverman, P.M. (1972). In: International Symposium on Protein Synthesis and Nucleic Acids, Proc.XI Latin Am.Symp., La Plata 1971. New York: Plenus Press"},{"key":"BF01732178_CR3","first-page":"31","volume-title":"Atlas of protein sequence and structure, Vol. 5","author":"W.C. Barker","year":"1972","unstructured":"Barker, W.C., McLaughlin, P.J., Dayhoff, M.O. (1972). Evolution of a complex system. In: Atlas of protein sequence and structure, Vol. 5, M.O. Dayhoff, ed., p. 31. Washington, D.C.: National Biomedical Research Foundation"},{"key":"BF01732178_CR4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/240395a0","volume":"240","author":"E.A. Barnard","year":"1972","unstructured":"Barnard, E.A., Cohen, M.S., Gold, M.H., Kim, J.-K. (1972). Nature 240, 395","journal-title":"Nature"},{"key":"BF01732178_CR5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1073\/pnas.65.2.349","volume":"65","author":"A.J. Bendich","year":"1970","unstructured":"Bendich, A.J., McCarthy, B.J. (1970). Proc.Natl.Acad.Sci. 65, 349","journal-title":"Proc.Natl.Acad.Sci."},{"key":"BF01732178_CR6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev.bi.42.070173.002351","volume":"42","author":"R. Benvenista","year":"1973","unstructured":"Benvenista, R., Davies, J. (1973). Ann.Rev.Biochem. 42, 471","journal-title":"Ann.Rev.Biochem."},{"key":"BF01732178_CR7","first-page":"75","volume-title":"Molecular cytogenetics","author":"M.L. Birnstiel","year":"1973","unstructured":"Birnstiel, M.L., Weinberg, E.S., Pardue, M.L. (1973). In: Molecular cytogenetics, B.A. Hamkalo, J. Papaconstantinou, eds., p. 75. New York: Plenum Press"},{"key":"BF01732178_CR8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1101\/SQB.1974.038.01.076","volume":"38","author":"J.O. Bishop","year":"1973","unstructured":"Bishop, J.O., Freeman, K.B. (1973). Cold Spring Harbor Symp.Quant.Biol. 38, 707","journal-title":"Cold Spring Harbor Symp.Quant.Biol."},{"key":"BF01732178_CR9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/250199a0","volume":"250","author":"J.O. Bishop","year":"1974","unstructured":"Bishop, J.O., Morton, J.C., Rosbash, M., Richardson, M. (1974). Nature 250, 199","journal-title":"Nature"},{"key":"BF01732178_CR10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.165.3891.349","volume":"165","author":"R.J. Britten","year":"1969","unstructured":"Britten, R.J., Davidson, E.H. (1969). Science 165, 349","journal-title":"Science"},{"key":"BF01732178_CR11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1126\/science.161.3841.529","volume":"161","author":"R.J. Britten","year":"1968","unstructured":"Britten, R.J., Kohne, D.E. (1968). Science 161, 529","journal-title":"Science"},{"key":"BF01732178_CR12","first-page":"224","volume-title":"Biochemical evolution and the origin of life","author":"E. Broda","year":"1971","unstructured":"Broda, E. (1971). Bioenergetic evolution. In: Biochemical evolution and the origin of life, E. Schoffeniels, ed., p. 224. Amsterdam: North Holland"},{"key":"BF01732178_CR13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF00326360","volume":"47","author":"A.K. Brown","year":"1974","unstructured":"Brown, A.K., Wilmore, P.J. (1974). Chromosoma 47, 379","journal-title":"Chromosoma"},{"key":"BF01732178_CR14","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1073\/pnas.70.6.1841","volume":"70","author":"J.H. Campbell","year":"1973","unstructured":"Campbell, J.H., Lengyel, J.A., Langridge, J. (1973). Proc.Natl.Acad.Sci. 70, 1841","journal-title":"Proc.Natl.Acad.Sci."},{"key":"BF01732178_CR15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1073\/pnas.56.1.177","volume":"56","author":"C.R. Cantor","year":"1966","unstructured":"Cantor, C.R., Jukes, T.H. (1966). Proc.Natl.Acad.Sci. 56, 177","journal-title":"Proc.Natl.Acad.Sci."},{"key":"BF01732178_CR16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1039\/qr9641800045","volume":"18","author":"B. Capon","year":"1964","unstructured":"Capon, B. (1964). Quart.Revs. 18, 45","journal-title":"Quart.Revs."},{"key":"BF01732178_CR17","unstructured":"Cavadore, J.C. (1971). Polycondensation d'\u03b1-amino acides en milieu aqueux. Th\u00e8se doctorat \u00e8s sciences physiques, Universit\u00e9 des Sciences et Techniques du Languedoc, Montpellier"},{"key":"BF01732178_CR18","first-page":"1245","volume":"51","author":"J.C. Cavadore","year":"1969","unstructured":"Cavadore, J.C., Previero, A. (1969). Bull.Soc.Chim.Biol. 51, 1245","journal-title":"Bull.Soc.Chim.Biol."},{"key":"BF01732178_CR19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0022-2836(69)90140-5","volume":"39","author":"M.A. Coletti-Previero","year":"1969","unstructured":"Coletti-Previero, M.A., Previero, A., Zuckerkandl, E. (1969). J.Mol.Biol. 39, 493","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0022-2836(72)90569-4","volume":"70","author":"P.M. Colman","year":"1972","unstructured":"Colman, P.M., Jansonius, J.N., Matthews, B.W. (1972). J.Mol.Biol. 70, 701","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1086\/282639","volume":"104","author":"K.W. Corbin","year":"1970","unstructured":"Corbin, K.W., Uzzell, T. (1970). Am.Nat. 104, 37","journal-title":"Am.Nat."},{"key":"BF01732178_CR22","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1086\/407817","volume":"48","author":"E.H. Davidson","year":"1973","unstructured":"Davidson, E.H., Britten, R.J. (1973). Quart.Revs.Biol. 48, 565","journal-title":"Quart.Revs.Biol."},{"key":"BF01732178_CR23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0022-2836(71)90396-2","volume":"56","author":"E.H. Davidson","year":"1971","unstructured":"Davidson, E.H., Hough, B.R. (1971). J.Mol.Biol. 56, 491","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR24","volume-title":"Atlas of protein sequence and structure, Vol. 5","author":"M.O. Dayhoff","year":"1972","unstructured":"Dayhoff, M.O. (1972). Atlas of protein sequence and structure, Vol. 5. Washington, D.C.: National Biomedical Research Foundation"},{"key":"BF01732178_CR25","first-page":"2314","volume":"33","author":"M.O. Dayhoff","year":"1974","unstructured":"Dayhoff, M.O. (1974). Fed.Proc. 33, 2314","journal-title":"Fed.Proc."},{"key":"BF01732178_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-2836(71)90116-1","volume":"57","author":"R.E. Dickerson","year":"1971","unstructured":"Dickerson, R.E. (1971). J.Mol.Biol. 57, 1","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1126\/science.152.3720.363","volume":"152","author":"R.V. Eck","year":"1966","unstructured":"Eck, R.V., Dayhoff, M.O. (1966). Science 152, 363","journal-title":"Science"},{"key":"BF01732178_CR28","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/2031350a0","volume":"203","author":"C.J. Epstein","year":"1964","unstructured":"Epstein, C.J. (1964). Nature 203, 1350","journal-title":"Nature"},{"key":"BF01732178_CR29","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1021\/bi00745a014","volume":"12","author":"M.N. Farquhar","year":"1973","unstructured":"Farquhar, M.N., McCarthy, B.J. (1973). Biochem. 12, 4113","journal-title":"Biochem."},{"key":"BF01732178_CR30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0300-9084(73)80030-6","volume":"55","author":"G. Faye","year":"1973","unstructured":"Faye, G., Fukuhara, H., Grandchamp, C., Lazowska, J., Michel, F., Casey, J., Getz, G.S., Locker, J., Rabinowitz, M., Balotin-Fukuhara, M., Coen, D., Deutsch, J., Dujou, B., Netter, P., Slonimski, P.P. (1973). Biochim. 55, 779","journal-title":"Biochim."},{"key":"BF01732178_CR31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2307\/2412448","volume":"19","author":"W.M. Fitch","year":"1970","unstructured":"Fitch, W.M. (1970a). System.Zool. 19, 99","journal-title":"System.Zool."},{"key":"BF01732178_CR32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0022-2836(70)90373-6","volume":"49","author":"W.M. Fitch","year":"1970","unstructured":"Fitch, W.M. (1970b). J.Mol.Biol. 49, 15","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF00602509","volume":"60","author":"S.W. Fox","year":"1973","unstructured":"Fox, S.W. (1973). Naturwiss. 60, 359","journal-title":"Naturwiss."},{"key":"BF01732178_CR34","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0010-406X(67)90051-5","volume":"20","author":"S.W. Fox","year":"1967","unstructured":"Fox, S.W., McCauley, R.J., Wood, A. (1967). Comp.Biochem.Physiol. 20, 773","journal-title":"Comp.Biochem.Physiol."},{"key":"BF01732178_CR35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0092-8674(74)90003-8","volume":"2","author":"G.A. Galau","year":"1974","unstructured":"Galau, G.A., Britten, R.J., Davidson, E.H. (1974). Cell 2, 9","journal-title":"Cell"},{"key":"BF01732178_CR36","first-page":"319","volume":"33","author":"J.G. Gall","year":"1971","unstructured":"Gall, J.G., Cohen, E.H., Polan, M.L. (1971). Chromosoma 33, 319","journal-title":"Chromosoma"},{"key":"BF01732178_CR37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF01797453","volume":"3","author":"L.L. Gatlin","year":"1974","unstructured":"Gatlin, L.L. (1974). J.Mol.Evol. 3, 189","journal-title":"J.Mol.Evol."},{"key":"BF01732178_CR38","first-page":"131","volume":"33","author":"M. Goodman","year":"1961","unstructured":"Goodman, M. (1961). Human Biol. 33, 131","journal-title":"Human Biol."},{"key":"BF01732178_CR39","first-page":"70","volume-title":"Protides of the biological fluids","author":"M. Goodman","year":"1964","unstructured":"Goodman, M. (1964). The specificity of proteins and the process of primate evolution. In: Protides of the biological fluids, H. Peeters, ed., p.70. Amsterdam: Elsevier"},{"key":"BF01732178_CR40","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1073\/pnas.70.12.3516","volume":"70","author":"R.B. Goldberg","year":"1973","unstructured":"Goldberg, R.B., Galau, G.A., Britten, R.J., Davidson, E.H. (1973). Proc.Natl.Acad.Sci. 70, 3516","journal-title":"Proc.Natl.Acad.Sci."},{"key":"BF01732178_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2911(08)60187-3","volume":"8","author":"H. Goldfine","year":"1972","unstructured":"Goldfine, H. (1972). Advan.Microbiol.Physiol. 8, 1","journal-title":"Advan.Microbiol.Physiol."},{"key":"BF01732178_CR42","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1083\/jcb.50.3.774","volume":"50","author":"J.R. Greenberg","year":"1971","unstructured":"Greenberg, J.R., Perry, R.P. (1971). J.Cell Biol. 50, 774","journal-title":"J.Cell Biol."},{"key":"BF01732178_CR43","first-page":"96","volume-title":"Biochemical evolution and the origin of life","author":"H.M. Grey","year":"1971","unstructured":"Grey, H.M. (1971). Phylogeny of immunoglobulins. In: Biochemical evolution and the origin of life, E. Schoffeniels, ed., p.96. Amsterdam: North Holland"},{"key":"BF01732178_CR44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1101\/SQB.1974.038.01.050","volume":"38","author":"T.A. Grigliatti","year":"1973","unstructured":"Grigliatti, T.A., White, B.N., Tener, G.M., Kaufman, T.C., Holden, J.J., Suzuki, D.T. (1973). Cold Spring Harbor Symp.Quant.Biol. 38, 461","journal-title":"Cold Spring Harbor Symp.Quant.Biol."},{"key":"BF01732178_CR45","first-page":"151","volume":"29","author":"B.S. Hartley","year":"1972","unstructured":"Hartley, B.S., Burleigh, B.D., Midwinter, C.G., Moore, C.H., Morris, H.R., Rigby, P.W.J., Smith, M.J., Taylor, S.S. (1972). Proc.FEBS Meetings 29, 151","journal-title":"Proc.FEBS Meetings"},{"key":"BF01732178_CR46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00334010","volume":"32","author":"W. Hennig","year":"1970","unstructured":"Hennig, W., Hennig, I., Stein, H. (1970). Chromosoma 32, 31","journal-title":"Chromosoma"},{"key":"BF01732178_CR47","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-1-4832-2734-4.50009-7","volume-title":"Evolving genes and proteins","author":"N.H. Horowitz","year":"1965","unstructured":"Horowitz, N.H. (1965). The evolution of biochemical syntheses -retrospect and prospect. In: Evolving genes and proteins, V. Bryson, H.J. Vogel, eds., p. 15. New York: Academic Press"},{"key":"BF01732178_CR48","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/189704a0","volume":"189","author":"V.M. Ingram","year":"1961","unstructured":"Ingram, V.M. (1961). Nature 189, 704","journal-title":"Nature"},{"key":"BF01732178_CR49","first-page":"304","volume-title":"Biochemical evolution and the origin of life","author":"Ch. Jeuniaux","year":"1971","unstructured":"Jeuniaux, Ch. (1971). On some biochemical aspects of regressive evolution in animals. In: Biochemical evolution and the origin of life, E.Schoffeniels, ed., p. 304. Amsterdam: North Holland"},{"key":"BF01732178_CR50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/newbio230165a0","volume":"230","author":"L. Kedes","year":"1971","unstructured":"Kedes, L., Birnstiel, M.L. (1971). Nature New Biol. 230, 165","journal-title":"Nature New Biol."},{"key":"BF01732178_CR51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S0016672300011459","volume":"11","author":"M. Kimura","year":"1968","unstructured":"Kimura, M. (1968). Genet.Res. 11, 247","journal-title":"Genet.Res."},{"key":"BF01732178_CR52","first-page":"69","volume-title":"Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability, Vol. 5","author":"J.L. King","year":"1972","unstructured":"King, J.L. (1972). The role of mutation in evolution. In: Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability, Vol. 5, p. 69. Berkeley: University of California Press"},{"key":"BF01732178_CR53","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.164.3881.788","volume":"164","author":"J.L. King","year":"1969","unstructured":"King, J.L., Jukes, T.H. (1969). Science 164, 788","journal-title":"Science"},{"key":"BF01732178_CR54","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/bi00753a011","volume":"11","author":"G.L. Klippenstein","year":"1972","unstructured":"Klippenstein, G.L. (1972). Biochem. 11, 372","journal-title":"Biochem."},{"key":"BF01732178_CR55","first-page":"1","volume":"26","author":"H.J.A. Koch","year":"1964","unstructured":"Koch, H.J.A., Bergstr\u00f6m, E., Evans, J.C. (1964). Mededel.Koninkl. Vlaamse Acad.Wetenschap.Belg. 26, 1","journal-title":"Mededel.Koninkl. Vlaamse Acad.Wetenschap.Belg."},{"key":"BF01732178_CR56","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/genetics\/72.2.297","volume":"72","author":"A.I. Koch","year":"1972","unstructured":"Koch, A.I. (1972). Genetics 72, 297","journal-title":"Genetics"},{"key":"BF01732178_CR57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S0033583500004765","volume":"3","author":"D.E. Kohne","year":"1970","unstructured":"Kohne, D.E. (1970). Quart.Revs.Biophys. 3, 327","journal-title":"Quart.Revs.Biophys."},{"key":"BF01732178_CR58","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/224149a0","volume":"224","author":"C.D. Laird","year":"1969","unstructured":"Laird, C.D., McConaughy, B.L., McCarthy, B.J. (1969). Nature 224, 149","journal-title":"Nature"},{"key":"BF01732178_CR59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0022-2836(73)90360-4","volume":"77","author":"C.C. Lee","year":"1973","unstructured":"Lee, C.C., Thomas, C.A.,Jr. (1973). J.Mol.Biol. 77, 25","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR60","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1101\/SQB.1951.016.01.014","volume":"16","author":"E.B. Lewis","year":"1951","unstructured":"Lewis, E.B. (1951). Cold Spring Harbor Symp.Quant.Biol. 16, 159","journal-title":"Cold Spring Harbor Symp.Quant.Biol."},{"key":"BF01732178_CR61","first-page":"475","volume-title":"Comprehensive biochemistry","author":"F. Lucas","year":"1968","unstructured":"Lucas, F., Rudall, K.M. (1968). In: Comprehensive biochemistry, M. Florkin, E.H. Stotz, eds., Vol. 26, part B, p. 475. Amsterdam: Elsevier"},{"key":"BF01732178_CR62","volume-title":"L'Evolution physiologique. Etude des pertes de fonctions chez les microorganismes","author":"A. Lwoff","year":"1943","unstructured":"Lwoff, A. (1943). L'Evolution physiologique. Etude des pertes de fonctions chez les microorganismes. Paris: Hermann"},{"key":"BF01732178_CR63","first-page":"129","volume":"22","author":"B.E.H. Maden","year":"1971","unstructured":"Maden, B.E.H. (1971). Progr.Biophys.Mol.Biol. 22, 129","journal-title":"Progr.Biophys.Mol.Biol."},{"key":"BF01732178_CR64","volume-title":"Molecular biology and the origin of species","author":"C. Manwell","year":"1970","unstructured":"Manwell, C., Baker, C.M.A. (1970). Molecular biology and the origin of species. London: Sidgwick and Jackson"},{"key":"BF01732178_CR65","volume-title":"Miami Winter Symp. 1, 33","author":"E. Margoliash","year":"1970","unstructured":"Margoliash, E., Fitch, W.M. (1970). Miami Winter Symp. 1, 33. Amsterdam: North Holland"},{"key":"BF01732178_CR66","volume-title":"Origin of eukaryotic cells","author":"L. Margulis","year":"1970","unstructured":"Margulis, L. (1970). Origin of eukaryotic cells. New Haven: Yale University Press"},{"key":"BF01732178_CR67","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1016\/S0021-9258(18)99412-3","volume":"242","author":"F.S. Markland","year":"1967","unstructured":"Markland, F.S., Smith, E.L. (1967). J.Biol.Chem. 242, 5198","journal-title":"J.Biol.Chem."},{"key":"BF01732178_CR68","unstructured":"Martin, F. (1974). Etude de l'h\u00e9moglobine d'un S\u00e9lacien,Scylliorhinus canicula. Th\u00e8se de doctorat \u00e8s-sciences physiques, Universit\u00e9 des Sciences et Techniques du Languedoc, Montpellier"},{"key":"BF01732178_CR69","first-page":"201","volume":"21","author":"H. Matsubara","year":"1969","unstructured":"Matsubara, H., Jukes, T.H., Cantor, C.R. (1969). Brookhaven Symp.Biol. 21, 201","journal-title":"Brookhaven Symp.Biol."},{"key":"BF01732178_CR70","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1101\/SQB.1974.038.01.081","volume":"38","author":"B.J. McCarthy","year":"1973","unstructured":"McCarthy, B.J., Nishiura, J.T., Doenecke, D., Nasser, D.S., Johnson, C.B. (1973). Cold Spring Harbor Symp.Quant.Biol. 38, 763","journal-title":"Cold Spring Harbor Symp.Quant.Biol."},{"key":"BF01732178_CR71","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/newbio229202a0","volume":"229","author":"A.D. McLachlan","year":"1971","unstructured":"McLachlan, A.D., Shotton, D.M. (1971). Nature New Biol. 229, 202","journal-title":"Nature New Biol."},{"key":"BF01732178_CR72","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF01653990","volume":"2","author":"P.J. McLaughlin","year":"1973","unstructured":"McLaughlin, P.J., Dayhoff, M.O. (1973). J.Mol.Evol. 2, 99","journal-title":"J.Mol.Evol."},{"key":"BF01732178_CR73","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF01660247","volume":"1","author":"Z.A. Medvedev","year":"1972","unstructured":"Medvedev, Z.A. (1972). J.Mol.Evol. 1, 270","journal-title":"J.Mol.Evol."},{"key":"BF01732178_CR74","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1086\/281505","volume":"81","author":"C.W. Metz","year":"1947","unstructured":"Metz, C.W. (1947). Am.Nat. 81, 81","journal-title":"Am.Nat."},{"key":"BF01732178_CR75","unstructured":"Miller, O.L., Hamkalo, B.A. (1972)."},{"key":"BF01732178_CR76","volume-title":"Chance and necessity","author":"J. Monod","year":"1971","unstructured":"Monod, J. (1971). Chance and necessity. New York: Knopf"},{"key":"BF01732178_CR77","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-0-12-211850-0.50014-8","volume-title":"Structure-function relationships of proteolytic enzymes","author":"H. Neurath","year":"1970","unstructured":"Neurath, H., Bradshaw, R.A., Arnon, R. (1970). Homology and phylogeny of proteolytic enzymes. In: Structure-function relationships of proteolytic enzymes, P. Desnuelle, H. Neurath, M. Ottesen, eds., p. 113. Copenhagen: Munksgaard"},{"key":"BF01732178_CR78","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-86659-3","volume-title":"Evolution by gene duplication","author":"S. Ohno","year":"1970","unstructured":"Ohno, S. (1970). Evolution by gene duplication. Berlin, Heidelberg, New York: Springer"},{"key":"BF01732178_CR79","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/233118a0","volume":"233","author":"T. Ohta","year":"1971","unstructured":"Ohta, T., Kimura, M. (1971). Nature 233, 118","journal-title":"Nature"},{"key":"BF01732178_CR80","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3891\/acta.chem.scand.17s-0009","volume":"17","author":"L. Pauling","year":"1963","unstructured":"Pauling, L., Zuckerkandl, E. (1963). Acta Chem.Scand. 17, S9","journal-title":"Acta Chem.Scand."},{"key":"BF01732178_CR81","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-4684-2019-7_10","volume-title":"Molecular evolution","author":"L. Pauling","year":"1972","unstructured":"Pauling, L., Zuckerkandl, E. (1972). Chance in evolution - some philosophical remarks. In: Molecular evolution, D.L. Rohlfing, A.I. Oparin, eds., p. 113. New York: Plenum"},{"key":"BF01732178_CR82","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0022-2836(65)80134-6","volume":"13","author":"M.F. Perutz","year":"1965","unstructured":"Perutz, M.F., Kendrew, J.C., Watson, H.C. (1965). J.Mol.Biol. 13, 669","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR83","volume-title":"Vergleichende Untersuchungen der H\u00e4moglobine verschiedener Chironomiden","author":"U. Plagens","year":"1971","unstructured":"Plagens, U. (1971). Vergleichende Untersuchungen der H\u00e4moglobine verschiedener Chironomiden. Inaugural-Dissertation, Ludwig-Maximilians Universit\u00e4t, Munich"},{"key":"BF01732178_CR84","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF02986099","volume":"48","author":"A.A. Prokofyeva-Belgovskaya","year":"1947","unstructured":"Prokofyeva-Belgovskaya, A.A. (1947). J.Genet. 48, 80","journal-title":"J.Genet."},{"key":"BF01732178_CR85","volume-title":"Comparative animal physiology","author":"C.Ladd Prosser","year":"1973","unstructured":"Prosser, C.Ladd (1973). Comparative animal physiology, 3rd edition. Philadelphia: W.B. Saunders","edition":"3rd edition"},{"key":"BF01732178_CR86","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/bj1230227","volume":"123","author":"R.V. Quincey","year":"1971","unstructured":"Quincey, R.V. (1971). Biochem.J. 123, 227","journal-title":"Biochem.J."},{"key":"BF01732178_CR87","first-page":"109","volume":"2","author":"P.M.M. Rae","year":"1972","unstructured":"Rae, P.M.M. (1972). Advan.Cell Mol.Biol. 2, 109","journal-title":"Advan.Cell Mol.Biol."},{"key":"BF01732178_CR88","first-page":"44","volume-title":"Evolution of genetic systems","author":"N.R. Rice","year":"1972","unstructured":"Rice, N.R. (1972). Change in repeated DNA in evolution. In: Evolution of genetic systems, H.H. Smith, ed., p. 44. New York: Gordon and Breach"},{"key":"BF01732178_CR89","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.ge.04.120170.001403","volume":"4","author":"H. Ris","year":"1970","unstructured":"Ris, H., Kubai, D.F. (1970). Ann.Rev.Genet. 4, 263","journal-title":"Ann.Rev.Genet."},{"key":"BF01732178_CR90","first-page":"3439","volume":"11","author":"J.D. Robertus","year":"1972","unstructured":"Robertus, J.D., Alden, R.A., Birktoft, J.J., Kraut, J., Powers, J.C., Wilcox, P.E. (1972). Biochem. 11, 3439","journal-title":"Biochem."},{"key":"BF01732178_CR91","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0003-9861(67)90286-X","volume":"118","author":"D.L. Rohlfing","year":"1967","unstructured":"Rohlfing, D.L., Fox, S.W. (1967). Arch.Biochem.Biophys. 118, 122","journal-title":"Arch.Biochem.Biophys."},{"key":"BF01732178_CR92","first-page":"373","volume":"20","author":"D.L. Rohlfing","year":"1969","unstructured":"Rohlfing, D.L. (1969). Advan.Catalysis 20, 373","journal-title":"Advan.Catalysis"},{"key":"BF01732178_CR93","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/250194a0","volume":"250","author":"M.G. Rossmann","year":"1974","unstructured":"Rossmann, M.G., Moras, D., Olsen, K.W. (1974). Nature 250, 194","journal-title":"Nature"},{"key":"BF01732178_CR94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-2836(70)90397-9","volume":"47","author":"R.L. Russel","year":"1970","unstructured":"Russel, R.L., Abelson, J.N., Landy, A., Gefter, M.L., Brenner, S., Smith, J.D. (1970). J.Mol.Biol. 47, 1","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR95","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/173848a0","volume":"173","author":"J.T. Ruud","year":"1954","unstructured":"Ruud, J.T. (1954). Nature 173, 848","journal-title":"Nature"},{"key":"BF01732178_CR96","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0300-9084(75)80310-5","volume":"57","author":"J.P. Sallei","year":"1975","unstructured":"Sallei, J.P., Zuckerkandl, E. (1975). Biochim. 57, 343","journal-title":"Biochim."},{"key":"BF01732178_CR97","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1016\/S0021-9258(20)81345-3","volume":"235","author":"H.K. Schachman","year":"1960","unstructured":"Schachman, H.K., Adler, J., Radding, C.M., Lehmann, I.R., Kornberg, A. (1960). J.Biol.Chem. 235, 3242","journal-title":"J.Biol.Chem."},{"key":"BF01732178_CR98","first-page":"249","volume-title":"Protides of the biological fluids","author":"W.A. Schroeder","year":"1970","unstructured":"Schroeder, W.A., Huisman, T.H.J. (1970). Investigations of molecular variation in human fetal hemoglobin in the infant and in certain hematological conditions in the adult. In: Protides of the biological fluids, H. Peeters, ed., p. 249. Oxford: Pergamon"},{"key":"BF01732178_CR99","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/250144a0","volume":"250","author":"G.E. Schulz","year":"1974","unstructured":"Schulz, G.E., Schirmer, R.H. (1974). Nature 250, 144","journal-title":"Nature"},{"key":"BF01732178_CR100","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0021-9258(18)96243-5","volume":"242","author":"R.D. Simoni","year":"1967","unstructured":"Simoni, R.D., Criddle, R.S., Stumpf, D.K. (1967). J.Biol.Chem. 242, 573","journal-title":"J.Biol.Chem."},{"key":"BF01732178_CR101","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1017\/S0080455X00009711","volume":"62","author":"B.M. Slizynski","year":"1945","unstructured":"Slizynski, B.M. (1945). Proc.Roy.Soc.Edinburgh B, 62, 114","journal-title":"Proc.Roy.Soc.Edinburgh B"},{"key":"BF01732178_CR102","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/physrev.1970.50.2.159","volume":"50","author":"E.L. Smith","year":"1970","unstructured":"Smith, E.L., De Lange, R.J., Bonner, J. (1970). Physiol.Rev. 50, 159","journal-title":"Physiol.Rev."},{"key":"BF01732178_CR103","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(74)90033-6","volume":"3","author":"A. Spradling","year":"1974","unstructured":"Spradling, A., Penman, S., Campo, M.S., Bishop, J.O. (1974). Cell 3, 23","journal-title":"Cell"},{"key":"BF01732178_CR104","volume-title":"Processes of organic evolution","author":"G. Ledyard Stebbins","year":"1971","unstructured":"Stebbins, G. Ledyard (1971). Processes of organic evolution, 2nd ed., Englewood Cliffs, N.J.: Prentice Hall","edition":"2nd ed."},{"key":"BF01732178_CR105","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0010-406X(66)90236-2","volume":"18","author":"J.B. Steen","year":"1966","unstructured":"Steen, J.B., Berg, T. (1966). Comp.Biochem.Physiol. 18, 517","journal-title":"Comp.Biochem.Physiol."},{"key":"BF01732178_CR106","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/252062a0","volume":"252","author":"P. Stenzel","year":"1974","unstructured":"Stenzel, P. (1974). Nature 252, 62","journal-title":"Nature"},{"key":"BF01732178_CR107","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0022-2836(72)90563-3","volume":"70","author":"Y. Suzuki","year":"1972","unstructured":"Suzuki, Y., Gage, L.P., Brown, D.B. (1972). J.Mol.Biol. 70, 637","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR108","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0079-6603(08)60237-8","volume":"5","author":"C.A. Thomas Jr.","year":"1966","unstructured":"Thomas, C.A., Jr. (1966). Progr.Nucl.Ac.Res.Mol.Biol. 5, 315","journal-title":"Progr.Nucl.Ac.Res.Mol.Biol."},{"key":"BF01732178_CR109","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/newbio238035a0","volume":"238","author":"K. Titani","year":"1972","unstructured":"Titani, K., Hermodson, M.A., Ericsson, L.H., Walsh, K.K., Neurath, H. (1972). Nature New Biol. 238, 35","journal-title":"Nature New Biol."},{"key":"BF01732178_CR110","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/219228a0","volume":"219","author":"P.M.B. Walker","year":"1968","unstructured":"Walker, P.M.B. (1968). Nature 219, 228","journal-title":"Nature"},{"key":"BF01732178_CR111","first-page":"147","volume":"23","author":"P.M.B. Walker","year":"1971","unstructured":"Walker, P.M.B. (1971). Progr.Biophys.Mol.Biol. 23, 147","journal-title":"Progr.Biophys.Mol.Biol."},{"key":"BF01732178_CR112","first-page":"52","volume-title":"Handbook of molecular cytology","author":"P.M.B. Walker","year":"1969","unstructured":"Walker, P.M.B., Flamm, W.G., Mclaren, A. (1969). Highly repetitive DNA in rodents. In: Handbook of molecular cytology, A. Lima de Faria, ed., p. 52. Amsterdam: North Holland"},{"key":"BF01732178_CR113","first-page":"111","volume":"6","author":"F. Walvig","year":"1958","unstructured":"Walvig, F. (1958). Nytt Magasin Zool. 6, 111","journal-title":"Nytt Magasin Zool."},{"key":"BF01732178_CR114","first-page":"150","volume-title":"Biochemical evolution and the origin of life","author":"D.C. Watts","year":"1971","unstructured":"Watts, D.C. (1971). Evolution of phosphagen kinases. In: Biochemical evolution and the origin of life, E. Schoffeniels, ed., p. 150. Amsterdam: North Holland"},{"key":"BF01732178_CR115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0303-2647(75)90067-2","volume":"6","author":"G.W. Welling","year":"1975","unstructured":"Welling, G.W., Leijenaar-van den Berg, G., van Dijk, B., van den Berg, A., Groen, G., Gaastra, W., Emmens, M., Beintema, J.J. (1975). BioSystems 6, 239","journal-title":"BioSystems"},{"key":"BF01732178_CR116","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1073\/pnas.54.6.1546","volume":"54","author":"C.R. Woese","year":"1965","unstructured":"Woese, C.R. (1965). Proc.Natl.Acad.Sci. 54, 1546","journal-title":"Proc.Natl.Acad.Sci."},{"key":"BF01732178_CR117","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0022-2836(69)90095-3","volume":"43","author":"C.R. Woese","year":"1969","unstructured":"Woese, C.R. (1969). J.Mol.Biol. 43, 235","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR118","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0022-5193(71)90214-1","volume":"33","author":"C.R. Woese","year":"1971","unstructured":"Woese, C.R. (1971). J.Theoret.Biol. 33, 29","journal-title":"J.Theoret.Biol."},{"key":"BF01732178_CR119","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01653939","volume":"2","author":"M. Ycas","year":"1972","unstructured":"Ycas, M. (1972). J.Mol.Evol. 2, 17","journal-title":"J.Mol.Evol."},{"key":"BF01732178_CR120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0022-5193(74)80035-4","volume":"44","author":"M. Ycas","year":"1974","unstructured":"Ycas, M. (1974). J.Theoret.Biol. 44, 145","journal-title":"J.Theoret.Biol."},{"key":"BF01732178_CR121","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1126\/science.174.4015.1200","volume":"174","author":"J.J. Yunis","year":"1971","unstructured":"Yunis, J.J., Yasmineh, W.G. (1971). Science 174, 1200","journal-title":"Science"},{"key":"BF01732178_CR122","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/216456a0","volume":"216","author":"S. Zamenhof","year":"1967","unstructured":"Zamenhof, S., Eichorn, H.H. (1967). Nature 216, 456","journal-title":"Nature"},{"key":"BF01732178_CR123","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1083\/jcb.5.1.51","volume":"5","author":"G. Zubay","year":"1959","unstructured":"Zubay, G., Watson, M.R. (1959). J.Biophys.Biochem.Cytol. 5, 51","journal-title":"J.Biophys.Biochem.Cytol."},{"key":"BF01732178_CR124","first-page":"1","volume":"38","author":"E. Zuckerkandl","year":"1960","unstructured":"Zuckerkandl, E. (1960). Ann.Inst.Oceanog. 38, 1","journal-title":"Ann.Inst.Oceanog."},{"key":"BF01732178_CR125","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/scientificamerican0565-110","volume":"212","author":"E. Zuckerkandl","year":"1965","unstructured":"Zuckerkandl, E. (1965). Sci.Am. 212, 110","journal-title":"Sci.Am."},{"key":"BF01732178_CR126","first-page":"369","volume":"15","author":"E. Zuckerkandl","year":"1970","unstructured":"Zuckerkandl, E. (1970). European J.Clin.Biol.Res. 15, 369","journal-title":"European J.Clin.Biol.Res."},{"key":"BF01732178_CR127","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0300-9084(72)80012-9","volume":"54","author":"E. Zuckerkandl","year":"1972","unstructured":"Zuckerkandl, E. (1972). Biochim. 54, 1095","journal-title":"Biochim."},{"key":"BF01732178_CR128","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0300-9084(74)80516-X","volume":"56","author":"E. Zuckerkandl","year":"1974","unstructured":"Zuckerkandl, E. (1974a). Biochim. 56, 937","journal-title":"Biochim."},{"key":"BF01732178_CR129","first-page":"69","volume-title":"Ecole de Roscoff - 1974","author":"E. Zuckerkandl","year":"1974","unstructured":"Zuckerkandl, E. (1974b). Accomplissements et perspectives de la paleogenetique chimique. In: Ecole de Roscoff - 1974, p. 69. Paris: Centre National de la Recherche Scientifique"},{"key":"BF01732178_CR130","unstructured":"Zuckerkandl, E. (1976a). J.Mol.Evol., in press"},{"key":"BF01732178_CR131","volume-title":"Molecular anthropology","author":"E. Zuckerkandl","year":"1976","unstructured":"Zuckerkandl, E. (1976b). Programs of gene action and progressive evolution. In: Molecular anthropology, M. Goodman, R.E. Tashian, eds. New York: Plenum, in press"},{"key":"BF01732178_CR132","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0022-2836(71)90311-1","volume":"59","author":"E. Zuckerkandl","year":"1971","unstructured":"Zuckerkandl, E., Derancourt, J., Vogel, H. (1971). J.Mol.Biol. 59, 473","journal-title":"J.Mol.Biol."},{"key":"BF01732178_CR133","first-page":"189","volume-title":"Horizons in biochemistry","author":"E. Zuckerkandl","year":"1962","unstructured":"Zuckerkandl, E., Pauling, L. (1962). Molecular disease, evolution, and genic heterogeneity. In: Horizons in biochemistry, M. Kasha, B. Pullman, eds., p. 189. New York: Academic Press"},{"key":"BF01732178_CR134","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0022-5193(65)90083-4","volume":"8","author":"E. Zuckerkandl","year":"1965","unstructured":"Zuckerkandl, E., Pauling, L. (1965a). J.Theoret.Biol. 8, 357","journal-title":"J.Theoret.Biol."},{"key":"BF01732178_CR135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-1-4832-2734-4.50017-6","volume-title":"Evolving genes and proteins","author":"E. Zuckerkandl","year":"1965","unstructured":"Zuckerkandl, E., Pauling, L. (1965b). Evolutionary divergence and convergence in proteins. In: Evolving genes and proteins., V. Bryson, H.J. Vogel, eds., p. 97. New York: Academic Press"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01732178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01732178\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01732178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T19:48:05Z","timestamp":1626032885000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01732178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,3]]},"references-count":135,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,3]]}},"alternative-id":["BF01732178"],"URL":"https:\/\/doi.org\/10.1007\/bf01732178","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,3]]}}}