{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:06:57Z","timestamp":1758280017459},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[1980,9,1]],"date-time":"1980-09-01T00:00:00Z","timestamp":336614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[1980,9]]},"DOI":"10.1007\/bf01804976","type":"journal-article","created":{"date-parts":[[2005,6,27]],"date-time":"2005-06-27T23:26:07Z","timestamp":1119914767000},"page":"153-209","source":"Crossref","is-referenced-by-count":44,"title":["Estimating the total number of nucleotide substitutions since the common ancestor of a pair of homologous genes: Comparison of several methods and three beta hemoglobin messenger RNA's"],"prefix":"10.1007","volume":"16","author":[{"given":"Walter M.","family":"Fitch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01804976_CR1","first-page":"233","volume":"19","author":"LL Cavalli-Sforza","year":"1967","unstructured":"Cavalli-Sforza LL, Edwards AWF (1967) Amer J Hum Gen 19:233\u2013257","journal-title":"Amer J Hum Gen"},{"key":"BF01804976_CR2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF01768027","volume":"11","author":"J Czelusniak","year":"1978","unstructured":"Czelusniak J, Goodman M, Moore GW (1978) J Mol Evol 11:75\u201385","journal-title":"J Mol Evol"},{"key":"BF01804976_CR3","unstructured":"Dayhoff MO (1972) Atlas of protein sequence and structure, vol 5"},{"key":"BF01804976_CR4","first-page":"577","volume":"49","author":"J Derancourt","year":"1967","unstructured":"Derancourt J, Lebor AS, Zuckerkandl E (1967) Bull Soc Chim Biol 49:577\u2013607","journal-title":"Bull Soc Chim Biol"},{"key":"BF01804976_CR5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2307\/3212580","volume":"11","author":"AJ Dobson","year":"1974","unstructured":"Dobson AJ (1974) J Appl Prob 11:32\u201342","journal-title":"J Appl Prob"},{"key":"BF01804976_CR6","unstructured":"Eck RV, Dayhoff MO (1966) Atlas of protein sequence and structure, vol 1"},{"key":"BF01804976_CR7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0092-8674(77)90090-3","volume":"10","author":"A Efstratiadis","year":"1977","unstructured":"Efstratiadis A, Kafatos FC, Maniatis T (1977) Cell 10:571\u2013585","journal-title":"Cell"},{"key":"BF01804976_CR8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00485794","volume":"5","author":"WM Fitch","year":"1971","unstructured":"Fitch WM (1971a) Biochem Gen 5:231\u2013241","journal-title":"Biochem Gen"},{"key":"BF01804976_CR9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2307\/2412116","volume":"20","author":"WM Fitch","year":"1971","unstructured":"Fitch WM (1971b) Syst Zool 20:406\u2013416","journal-title":"Syst Zool"},{"key":"BF01804976_CR10","first-page":"199","volume":"10","author":"WM Fitch","year":"1972","unstructured":"Fitch WM (1972a) Haematol Bluttransfus 10:199\u2013215","journal-title":"Haematol Bluttransfus"},{"key":"BF01804976_CR11","first-page":"186","volume":"23","author":"WM Fitch","year":"1972","unstructured":"Fitch WM (1972b) Brookhaven Symp Biol 23:186\u2013216","journal-title":"Brookhaven Symp Biol"},{"key":"BF01804976_CR12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev.ge.07.120173.002015","volume":"7","author":"WM Fitch","year":"1973","unstructured":"Fitch WM (1973a) Annu Rev Genet 7:343\u2013380","journal-title":"Annu Rev Genet"},{"key":"BF01804976_CR13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01653998","volume":"2","author":"WM Fitch","year":"1973","unstructured":"Fitch WM (1973b) J Mol Evol 2:181\u2013186","journal-title":"J Mol Evol"},{"key":"BF01804976_CR14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01653992","volume":"2","author":"WM Fitch","year":"1973","unstructured":"Fitch WM (1973c) J Mol Evol 2:123\u2013136","journal-title":"J Mol Evol"},{"key":"BF01804976_CR15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01738880","volume":"8","author":"WM Fitch","year":"1976","unstructured":"Fitch WM (1976a) J Mol Evol 8:13\u201340","journal-title":"J Mol Evol"},{"key":"BF01804976_CR16","first-page":"160","volume-title":"Molecular study of biological evolution","author":"WM Fitch","year":"1976","unstructured":"Fitch WM (1976b) In: Ayala FJ (ed) Molecular study of biological evolution. Sinauer, Sunderland, MA, p 160"},{"key":"BF01804976_CR17","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1126\/science.996548","volume":"194","author":"WM Fitch","year":"1976","unstructured":"Fitch WM (1976c) Science 194:1173\u20131174","journal-title":"Science"},{"key":"BF01804976_CR18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01796042","volume":"3","author":"WM Fitch","year":"1974","unstructured":"Fitch WM, Farris JS (1974) J Mol Evol 3:263\u2013278","journal-title":"J Mol Evol"},{"key":"BF01804976_CR19","first-page":"2092","volume":"35","author":"WM Fitch","year":"1976","unstructured":"Fitch WM, Langley CH (1976a) Fed Proc 35:2092\u20132097","journal-title":"Fed Proc"},{"key":"BF01804976_CR20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4615-8783-5_10","volume-title":"Progress in molecular anthropology","author":"WM Fitch","year":"1976","unstructured":"Fitch WM, Langley CH (1976b) In: Goodman M, Tashian, RE (eds) Progress in molecular anthropology. Plenum Press, New York, p 197"},{"key":"BF01804976_CR21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00487738","volume":"1","author":"WM Fitch","year":"1967","unstructured":"Fitch WM, Margoliash E (1967) Biochem Genet 1:65\u201371","journal-title":"Biochem Genet"},{"key":"BF01804976_CR22","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF00486096","volume":"4","author":"WM Fitch","year":"1970","unstructured":"Fitch WM, Markowitz E (1970) Biochem Genet 4:579\u2013593","journal-title":"Biochem Genet"},{"key":"BF01804976_CR23","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3109\/03630267709003915","volume":"1","author":"BG Forget","year":"1977","unstructured":"Forget BG (1977) Hemoglobin 1:879\u2013881","journal-title":"Hemoglobin"},{"key":"BF01804976_CR24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/276236a0","volume":"000","author":"GN Godson","year":"1978","unstructured":"Godson GN, Barrell BG, Staden R, Fiddes JC (1978) Nature 000:236\u2013247","journal-title":"Nature"},{"key":"BF01804976_CR25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-1-4615-8783-5_17","volume-title":"Progress in molecular anthropology","author":"M Goodman","year":"1976","unstructured":"Goodman M (1976) In: Goodman M, Tashian RE (eds) Progress in molecular anthropology. Plenum Press, New York, p 321"},{"key":"BF01804976_CR26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01796133","volume":"10","author":"M Goodman","year":"1977","unstructured":"Goodman M, Moore GW (1977) J Mol Evol 10:7\u201347","journal-title":"J Mol Evol"},{"key":"BF01804976_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01795974","volume":"3","author":"M Goodman","year":"1974","unstructured":"Goodman M, Moore GW, Barnabas J, Matsuda G (1974) J Mol Evol 3:1\u201348","journal-title":"J Mol Evol"},{"key":"BF01804976_CR28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01659159","volume":"1","author":"R Holmquist","year":"1972","unstructured":"Holmquist R (1972a) J Mol Evol 1:115\u2013133","journal-title":"J Mol Evol"},{"key":"BF01804976_CR29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/BF01659160","volume":"1","author":"R Holmquist","year":"1972","unstructured":"Holmquist R (1972b) J Mol Evol 1:134\u2013149","journal-title":"J Mol Evol"},{"key":"BF01804976_CR30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF01660240","volume":"1","author":"R Holmquist","year":"1972","unstructured":"Holmquist R (1972c) J Mol Evol 1:211\u2013222","journal-title":"J Mol Evol"},{"key":"BF01804976_CR31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-4615-8783-5_6","volume-title":"Progress in molecular anthropology","author":"R Holmquist","year":"1976","unstructured":"Holmquist R (1976a) In: Goodman M, Tashian RE (eds) Progress in molecular anthropology. Plenum Press, New York, p 89"},{"key":"BF01804976_CR32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF01739259","volume":"8","author":"R Holmquist","year":"1976","unstructured":"Holmquist R (1976b) J Mol Evol 8:337\u2013349","journal-title":"J Mol Evol"},{"key":"BF01804976_CR33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF01733843","volume":"11","author":"R Holmquist","year":"1978","unstructured":"Holmquist R (1978a) J Mol Evol 11:361\u2013374","journal-title":"J Mol Evol"},{"key":"BF01804976_CR34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01732543","volume":"12","author":"R Holmquist","year":"1978","unstructured":"Holmquist R (1978b) J Mol Evol 12:17\u201324","journal-title":"J Mol Evol"},{"key":"BF01804976_CR35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF01653938","volume":"2","author":"R Holmquist","year":"1972","unstructured":"Holmquist R, Jukes TH (1972) J Mol Evol 2:10\u201316","journal-title":"J Mol Evol"},{"key":"BF01804976_CR36","doi-asserted-by":"crossref","unstructured":"Holmquist P, Pearl D (1980) J Mol Evol 16:","DOI":"10.1007\/BF01804977"},{"key":"BF01804976_CR37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0022-2836(72)90326-9","volume":"64","author":"R Holmquist","year":"1972","unstructured":"Holmquist R, Cantor CR, Jukes TH (1972) J Mol Biol 64:145\u2013162","journal-title":"J Mol Biol"},{"key":"BF01804976_CR38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-2836(76)90194-7","volume":"105","author":"R Holmquist","year":"1976","unstructured":"Holmquist R, Jukes TH, Moise H, Goodman M, Moore GW (1976) J Mol Biol 105:39\u201374","journal-title":"J Mol Biol"},{"key":"BF01804976_CR39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01733888","volume":"11","author":"TH Jukes","year":"1978","unstructured":"Jukes TH (1978a) J Mol Evol 11:121\u2013127","journal-title":"J Mol Evol"},{"key":"BF01804976_CR40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF01734488","volume":"11","author":"TH Jukes","year":"1978","unstructured":"Jukes TH (1978b) J Mol Evol 11:267\u2013269","journal-title":"J Mol Evol"},{"key":"BF01804976_CR41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0022-2836(72)90327-0","volume":"64","author":"TH Jukes","year":"1972","unstructured":"Jukes TH, Holmquist R (1972) J Mol Biol 64:163\u2013179","journal-title":"J Mol Biol"},{"key":"BF01804976_CR42","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1073\/pnas.74.12.5618","volume":"12","author":"FC Kafatos","year":"1977","unstructured":"Kafatos FC, Efstratiadis A, Forget R, Weissman SM (1977) Proc Nat Acad Sci USA 12:5618\u20135622","journal-title":"Proc Nat Acad Sci USA"},{"key":"BF01804976_CR43","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/217624a0","volume":"217","author":"M Kimura","year":"1968","unstructured":"Kimura M (1968) Nature 217:624\u2013626","journal-title":"Nature"},{"key":"BF01804976_CR44","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1073\/pnas.76.7.3440","volume":"76","author":"M Kimura","year":"1979","unstructured":"Kimura M (1979) Proc Nat Acad Sci USA 76:3440\u20133444","journal-title":"Proc Nat Acad Sci USA"},{"key":"BF01804976_CR45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01653945","volume":"2","author":"M Kimura","year":"1972","unstructured":"Kimura M, Ohta T (1972) J Mol Evol 2:87\u201390","journal-title":"J Mol Evol"},{"key":"BF01804976_CR46","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.164.3881.788","volume":"164","author":"JL King","year":"1969","unstructured":"King JL, Jukes TH (1969) Science 164:788\u2013798","journal-title":"Science"},{"key":"BF01804976_CR47","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0092-8674(78)90040-5","volume":"15","author":"DA Konkel","year":"1978","unstructured":"Konkel DA, Tilghman SM, Leder P (1978) Cell 15:1125\u20131132","journal-title":"Cell"},{"key":"BF01804976_CR48","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1749-6632.1968.tb11901.x","volume":"151","author":"E Margoliash","year":"1968","unstructured":"Margoliash E, Fitch WM (1968) N Y Acad Sci 151:359\u2013381","journal-title":"N Y Acad Sci"},{"key":"BF01804976_CR49","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/B978-1-4832-2734-4.50023-1","volume-title":"Evolving genes and proteins","author":"E Margoliash","year":"1965","unstructured":"Margoliash E, Smith E (1965) In: Bryson V, Vogel H (eds) Evolving genes and proteins, Academic Press, New York, p 221"},{"key":"BF01804976_CR50","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1016\/S0021-9258(17)40156-6","volume":"252","author":"CA Marotta","year":"1977","unstructured":"Marotta CA, Wilson JT, Forget BG, Weissman SM (1977) J Biol Chem 252:5040\u20135053","journal-title":"J Biol Chem"},{"key":"BF01804976_CR51","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0022-5193(73)90252-X","volume":"38","author":"GW Moore","year":"1973","unstructured":"Moore GW, Barnabas J, Goodman M (1973) J Theor Biol 38:459\u2013485","journal-title":"J Theor Biol"},{"key":"BF01804976_CR52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0022-2836(76)90193-5","volume":"105","author":"GW Moore","year":"1976","unstructured":"Moore GW, Goodman M, Callahan C, Holmquist R, Moise H (1976) J Mol Biol 105:15\u201337","journal-title":"J Mol Biol"},{"key":"BF01804976_CR53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF01733841","volume":"11","author":"M Nei","year":"1978","unstructured":"Nei M, Tateno Y (1978) J Mol Evol 11:333\u2013347","journal-title":"J Mol Evol"},{"key":"BF01804976_CR54","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/BF01659391","volume":"1","author":"T Ohta","year":"1971","unstructured":"Ohta T, Kimura M (1971) J Mol Evol 1:18\u201325","journal-title":"J Mol Evol"},{"key":"BF01804976_CR55","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/270486a0","volume":"270","author":"PH Seeburg","year":"1977","unstructured":"Seeburg PH, Shine J, Martial JA, Baxter JD, Goodman HM (1977) Nature 270:486\u2013499","journal-title":"Nature"},{"key":"BF01804976_CR56","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0092-8674(79)90091-6","volume":"16","author":"M Smith","year":"1979","unstructured":"Smith M, Leung DW, Gillam S, Ashell CR, Montgomery DL, Hall BD (1979) Cell 16:753\u2013762","journal-title":"Cell"},{"key":"BF01804976_CR57","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1101\/SQB.1966.031.01.094","volume":"31","author":"H Subak-Sharpe","year":"1966","unstructured":"Subak-Sharpe H, Burk RR, Crawford LV, Morrison JM, Hay J, Keir HM (1966) Cold Spring Harbor Symp Quant Biol 31:737\u2013748","journal-title":"Cold Spring Harbor Symp Quant Biol"},{"key":"BF01804976_CR58","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0021-9258(19)73967-2","volume":"237","author":"MN Swartz","year":"1962","unstructured":"Swartz MN, Trautner T, Kornberg A (1962) J Biol Chem 237:1961\u20131967","journal-title":"J Biol Chem"},{"key":"BF01804976_CR59","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF01768026","volume":"11","author":"Y Tateno","year":"1978","unstructured":"Tateno Y, Nei M (1978) J Mol Evol 11:67\u201373","journal-title":"J Mol Evol"},{"key":"BF01804976_CR60","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.325648","volume":"196","author":"A Ulrich","year":"1977","unstructured":"Ulrich A, Shine J, Chirgwin J, Pictet R, Tischer E, Rutter WJ, Goodman HM (1977) Science 196:1313\u20131319","journal-title":"Science"},{"key":"BF01804976_CR61","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF01653962","volume":"1","author":"F Vogel","year":"1972","unstructured":"Vogel F (1972) J Mol Evol 1:334\u2013367","journal-title":"J Mol Evol"},{"key":"BF01804976_CR62","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01732746","volume":"9","author":"F Vogel","year":"1977","unstructured":"Vogel F, Kopun M (1977) J Mol Evol 9:159\u2013180","journal-title":"J Mol Evol"},{"key":"BF01804976_CR63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0022-5193(77)90351-4","volume":"64","author":"MS Waterman","year":"1977","unstructured":"Waterman MS, Smith TF, Singh M, Beyer WA (1977) J Theor Biol 64:199\u2013213","journal-title":"J Theor Biol"},{"key":"BF01804976_CR64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-1-4832-2734-4.50017-6","volume-title":"Evolving genes and proteins","author":"E Zuckerkandl","year":"1965","unstructured":"Zuckerkandl E, Pauling L (1965) In: Bryson V, Vogel HJ (eds) Evolving genes and proteins. Academic Press, New York, p 97"},{"key":"BF01804976_CR65","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0022-2836(71)90311-1","volume":"59","author":"E Zuckerkandl","year":"1971","unstructured":"Zuckerkandl E, Derancourt J, Vogel H (1971) J Mol Evol 59:473\u2013490","journal-title":"J Mol Evol"}],"container-title":["Journal Of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01804976.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01804976\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01804976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T12:11:29Z","timestamp":1626091889000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01804976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9]]},"references-count":65,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1980,9]]}},"alternative-id":["BF01804976"],"URL":"https:\/\/doi.org\/10.1007\/bf01804976","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,9]]}}}