{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:12:25Z","timestamp":1771017145457,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1987,4,1]],"date-time":"1987-04-01T00:00:00Z","timestamp":544233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[1987,4]]},"DOI":"10.1007\/bf02134130","type":"journal-article","created":{"date-parts":[[2005,9,14]],"date-time":"2005-09-14T18:03:49Z","timestamp":1126721029000},"page":"319-329","source":"Crossref","is-referenced-by-count":61,"title":["Evolution of keratin genes: Different protein domains evolve by different pathways"],"prefix":"10.1007","volume":"24","author":[{"given":"Elaine M.","family":"Klinge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolande R.","family":"Sylvestre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin M.","family":"Freedberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Blumenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02134130_CR1","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1073\/pnas.81.17.5561","volume":"81","author":"E Azen","year":"1984","unstructured":"Azen E, Lyons KM, McGonigol T, Barrett NL, Clements SL, Maeda N, Vanin EF, Carlson DM, Smithies O (1984) Clones from the human gene complex coding for salivary prolinerich proteins. Proc Natl Acad Sci USA 81:5561\u20135565","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/295031a0","volume":"295","author":"GI Bell","year":"1982","unstructured":"Bell GI, Selby MJ, Rutter WJ (1982) The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature 295:31\u201335","journal-title":"Nature"},{"key":"BF02134130_CR3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000132253","volume":"42","author":"M Blumenberg","year":"1986","unstructured":"Blumenberg M, Savtchenko ES (1986) Linkage of human keratin genes. Cytogenet Cell Genet 42:65\u201371","journal-title":"Cytogenet Cell Genet"},{"key":"BF02134130_CR4","first-page":"171","volume-title":"Proteins","author":"TE Creighton","year":"1984","unstructured":"Creighton TE (1984) Proteins. W. H. Freeman, New York, pp 171\u2013176"},{"key":"BF02134130_CR5","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/176780a0","volume":"176","author":"FHC Crick","year":"1955","unstructured":"Crick FHC, Rich A (1955) Structure of polyglycine II. Nature 176:780\u2013782","journal-title":"Nature"},{"key":"BF02134130_CR6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0022-2836(78)90070-0","volume":"120","author":"RF Doolittle","year":"1978","unstructured":"Doolittle RF, Goldbaum DM, Doolittle LR (1978) Designation of sequences involved in the \u201ccoiled-coil\u201d interdomainal connections in fibrinogen: construction of an atomic scale model. J Mol Biol 120:311\u2013325","journal-title":"J Mol Biol"},{"key":"BF02134130_CR7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0092-8674(82)90179-9","volume":"29","author":"TH Eickbush","year":"1982","unstructured":"Eickbush TH, Kafatos FC (1982) A walk in the chorion locus ofBombyx mori. Cell 29:633\u2013643","journal-title":"Cell"},{"key":"BF02134130_CR8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0092-8674(84)90031-X","volume":"3","author":"WW Franke","year":"1984","unstructured":"Franke WW, Schmidt E, Mittnacht S, Grund C, Jorcano J (1984) Integration of different keratins into the same filament system after microinjection of mRNA for epidermal keratins into kidney epithelial cells. Cell 3:813\u2013824","journal-title":"Cell"},{"key":"BF02134130_CR9","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/j.1460-2075.1982.tb01368.x","volume":"1","author":"N Geisler","year":"1982","unstructured":"Geisler N, Weber K (1982) The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins. EMBO J 1:1649\u20131656","journal-title":"EMBO J"},{"key":"BF02134130_CR10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0092-8674(82)90033-2","volume":"30","author":"N Geisler","year":"1982","unstructured":"Geisler N, Kaufman E, Weber K (1982) Protein chemical characterization of three structurally distinct domains along the protofilament unit of desmin 10 nm filament. Cell 30:277\u2013286","journal-title":"Cell"},{"key":"BF02134130_CR11","first-page":"141","volume-title":"Molecular evolution","author":"M Goodman","year":"1976","unstructured":"Goodman M (1976) Protein sequence in phylogeny. In: Ayala FJ (ed) Molecular evolution. Sinauer Associates, Sunderland, Massachusetts, pp 141\u2013158"},{"key":"BF02134130_CR12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0022-2836(85)90132-9","volume":"230","author":"SJ Hamodrakas","year":"1985","unstructured":"Hamodrakas SJ, Etmektzoglu T, Kafatos FC (1985) Amino acid periodicities and their structural implications for the evolutionarily conservative central domain of some silkmoth chorion proteins. J Mol Biol 230:583\u2013589","journal-title":"J Mol Biol"},{"key":"BF02134130_CR13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0092-8674(82)90424-X","volume":"31","author":"I Hanukoglu","year":"1982","unstructured":"Hanukoglu I, Fuchs E (1982) The cDNA sequence of a human epidermal keratin. Cell 31:243\u2013251","journal-title":"Cell"},{"key":"BF02134130_CR14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(83)90034-X","volume":"33","author":"I Hanukoglu","year":"1983","unstructured":"Hanukoglu I, Fuchs E (1983) The cDNA sequence of a type II cytoskeletal keratin reveals a constant and variable structural domain among keratins. Cell 33:915\u2013924","journal-title":"Cell"},{"key":"BF02134130_CR15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-4827(81)90106-3","volume":"132","author":"D Henderson","year":"1981","unstructured":"Henderson D, Weber K (1981) Immuno-electron microscopical identification of the two types of intermediate filaments in established epithelial cells. Exp Cell Res 132:297\u2013311","journal-title":"Exp Cell Res"},{"key":"BF02134130_CR16","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1073\/pnas.81.14.4452","volume":"81","author":"K Iatrou","year":"1984","unstructured":"Iatrou K, Tsitilou SG, Kafatos FC (1984) DNA sequence transfer between two high-cysteine chorion gene families in the silkmothBombyx mori. Proc Natl Acad Sci USA 81:4452\u20134456","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR17","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1073\/pnas.82.7.1896","volume":"82","author":"LD Johnson","year":"1985","unstructured":"Johnson LD, Idler WW, Zhou W, Roop DR, Steinert PM (1985) Structure of a gene for human epidermal 67KD keratin. Proc Natl Acad Sci USA 82:1896\u20131900","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1432-0436.1984.tb00278.x","volume":"28","author":"JL Jorcano","year":"1984","unstructured":"Jorcano JL, Franz J, Franke WW (1984) Amino acid sequence diversity between bovine epidermal cytokeratin polypeptides of the basic (type II) subfamily as determined from cDNA clones. Differentiation 28:155\u2013163","journal-title":"Differentiation"},{"key":"BF02134130_CR19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/MCB.3.4.495","volume":"3","author":"KH Kim","year":"1983","unstructured":"Kim KH, Rheinwald JG, Fuchs E (1983) Tissue specificity of epithelial keratins: different expression of mRNAs from two different multigene families. Mol Cell Biol 3:495\u2013502","journal-title":"Mol Cell Biol"},{"key":"BF02134130_CR20","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1016\/S0021-9258(18)88905-0","volume":"260","author":"TM Krieg","year":"1985","unstructured":"Krieg TM, Schofer MP, Cheng CK, Flaherty D, Steinert PM, Roop DR (1985) Organization of a type II keratin gene. J Biol Chem 260:5867\u20135870","journal-title":"J Biol Chem"},{"key":"BF02134130_CR21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.bi.51.070182.001251","volume":"51","author":"E Lazarides","year":"1982","unstructured":"Lazarides E (1982) Intermediate filaments: a chemically heterogeneous developmentally regulated class of proteins. Annu Rev Biochem 51:219\u2013267","journal-title":"Annu Rev Biochem"},{"key":"BF02134130_CR22","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1002\/j.1460-2075.1984.tb02290.x","volume":"3","author":"ME Lehnert","year":"1984","unstructured":"Lehnert ME, Jorcano JL, Zentgrof H, Blessing M, Franz JK, Franke WW (1984) Characterization of bovine keratin genes: similarities of exon patterns in genes coding for different keratins. EMBO J 3:3279\u20133287","journal-title":"EMBO J"},{"key":"BF02134130_CR23","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1073\/pnas.81.9.2743","volume":"81","author":"SA Lewis","year":"1984","unstructured":"Lewis SA, Balcarek JM, Krek V, Shelanski M, Cowan NJ (1984) Sequence of a cDNA clone encoding mouse glial fibrillary acidic proteins: structural conservation of intermediate filaments. Proc Natl Acad Sci USA 81:2743\u20132746","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0092-8674(78)90036-3","volume":"15","author":"T Maniatis","year":"1978","unstructured":"Maniatis T, Richardson RC, Lacy E, Lacier J, O'Connell C, Quon D, Sim DK, Efstratidis A (1978) The isolation of structural genes from libraries of eukaryotic DNA. Cell 15:687\u2013701","journal-title":"Cell"},{"key":"BF02134130_CR25","first-page":"320","volume-title":"Molecular cloning","author":"T Maniatis","year":"1982","unstructured":"Maniatis T, Fritsch EF, Sambrook J (1982) Screening bacteriophage lambda plaques by hybridization. In: Molecular cloning. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 320\u2013321"},{"key":"BF02134130_CR26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0092-8674(84)90456-2","volume":"39","author":"D Marchuk","year":"1984","unstructured":"Marchuk D, McCrohon S, Fuchs E (1984) Remarkable conservation of structure among intermediate filament genes. Cell 39:491\u2013498","journal-title":"Cell"},{"key":"BF02134130_CR27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0022-2836(75)80119-7","volume":"98","author":"AD McLachlan","year":"1975","unstructured":"McLachlan AD, Stewart M (1975) Tropomyosin coiled-coil interactions: evidence for an unstaggered structure. J Mol Biol 98:293\u2013304","journal-title":"J Mol Biol"},{"key":"BF02134130_CR28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0092-8674(83)90224-6","volume":"35","author":"W Quax","year":"1983","unstructured":"Quax W, Egberts WV, Hendriks W, Quax-Jenken Y, Bloemendal H (1983) The structure of the vimentin gene. Cell 35:215\u2013223","journal-title":"Cell"},{"key":"BF02134130_CR29","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1073\/pnas.80.12.3548","volume":"80","author":"Y Quax-Jenken","year":"1983","unstructured":"Quax-Jenken Y, Quax YJ, Bloemendal H (1983) Primary and secondary structure of hamster vimentin predicted from the nucleotide sequence. Proc Natl Acad Sci USA 80:3548\u20133552","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR30","first-page":"168","volume":"112","author":"GN Ramachandran","year":"1966","unstructured":"Ramachandran GN, Sasusekharan V, Ramakrishnan C (1966) Molecular structure of polyglycine II. Biochem Biophys Acta 112:168\u2013170","journal-title":"Biochem Biophys Acta"},{"key":"BF02134130_CR31","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1073\/pnas.80.9.2618","volume":"80","author":"FCS Ramaekers","year":"1983","unstructured":"Ramaekers FCS, Haag D, Kant A, Moesker O, Jap PHK, Vooijs JP (1983) Coexpression of keratin and vimentin type intermediate filaments in human metastatic carcinoma cells. Proc Natl Acad Sci USA 80:2618\u20132622","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR32","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1073\/pnas.80.4.1043","volume":"80","author":"JC Regier","year":"1983","unstructured":"Regier JC, Kafatos FC, Hamodrakas SJ (1983) Silkmoth chorion multigene families constitute a superfamily: comparison of C and B family sequences. Proc Natl Acad Sci USA 80:1043\u20131047","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR33","first-page":"217","volume-title":"The cancer cell","author":"JG Rheinwald","year":"1984","unstructured":"Rheinwald JG, O'Connell TM, Connell ND, Rybok SM, Allen-Hoffman BL, LaRocca PJ, Wu Y-J, Rehwoldt SM (1984) Expression of specific keratin subsets and vimentin in normal human epithelial cells: a function of cell type and conditions of growth during serial cell culture. In: Levine A, Topp W, Vande Woulde G, Watson JP (eds) The cancer cell. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 217\u2013227"},{"key":"BF02134130_CR34","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1073\/pnas.79.11.3551","volume":"79","author":"GC Rodakis","year":"1982","unstructured":"Rodakis GC, Kafatos FC (1982) Origin of evolutionary novelty in proteins: how a high-cysteine chorion protein has evolved. Proc Natl Acad Sci USA 79:3551\u20133555","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR35","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1016\/S0021-9258(17)39682-5","volume":"259","author":"DR Roop","year":"1984","unstructured":"Roop DR, Cheng CK, Titterington L, Meyers CA, Stanley JR, Steinert PM, Yuspa SH (1984) Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies. J Biol Chem 259:8037\u20138040","journal-title":"J Biol Chem"},{"key":"BF02134130_CR36","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1073\/pnas.69.12.3800","volume":"69","author":"J Sodek","year":"1972","unstructured":"Sodek J, Hodges RS, Smillie LB, Juosek L (1972) Amino-acid sequence of rabbit skeletal tropomyosin and its coiled-coil structure. Proc Natl Acad Sci USA 69:3800\u20133804","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0022-2836(78)90376-5","volume":"123","author":"PM Steinert","year":"1978","unstructured":"Steinert PM (1978) Structure of the three chain unit of the bovine epidermal keratin filament. J Mol Biol 123:69\u201370","journal-title":"J Mol Biol"},{"key":"BF02134130_CR38","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.1073\/pnas.77.8.4534","volume":"77","author":"PM Steinert","year":"1980","unstructured":"Steinert PM, Idler WW, Goldman RD (1980) Intermediate filaments of baby hamster kidney (BHK-21) cells and bovine epidermal keratinocytes have similar ultrastructures and subunit structures. Proc Natl Acad Sci USA 77:4534\u20134538","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR39","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/302794a0","volume":"302","author":"PM Steinert","year":"1983","unstructured":"Steinert PM, Rice RH, Roop DR, Trus BL, Steven AC (1983) Complete amino acid sequence of mouse epidermal keratin subunit and implications for the structure of intermediate filaments. Nature 302:794\u2013800","journal-title":"Nature"},{"key":"BF02134130_CR40","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1073\/pnas.81.18.5709","volume":"81","author":"PM Steinert","year":"1984","unstructured":"Steinert PM, Parry DAD, Racoosis EL, Wloller W, Steven AC, Trus BL, Roop DR (1984) A complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da. Proc Natl Acad Sci USA 81:5709\u20135713","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR41","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1016\/S0021-9258(18)88900-1","volume":"260","author":"PM Steinert","year":"1985","unstructured":"Steinert PM, Parry DAD, Idler WW, Johnson LD, Steven AC, Roop DR (1985a) The amino acid sequence of mouse and human epidermal type II keratins of MW67,000. J Biol Chem 260:7142\u20137149","journal-title":"J Biol Chem"},{"key":"BF02134130_CR42","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(85)90098-4","volume":"42","author":"PM Steinert","year":"1985","unstructured":"Steinert PM, Steven AC, Roop DR (1985b) The molecular biology of intermediate filaments. Cell 42:411\u2013419","journal-title":"Cell"},{"key":"BF02134130_CR43","first-page":"1095","volume":"81","author":"T Sun","year":"1983","unstructured":"Sun T, Eichner R, Nelson WG, Tseng RA, Weiss M, Jarvinen M (1983) Keratin classes: molecular markers for different types of epithelial differentiation. J Invest Dermatol 81:1095\u20131102","journal-title":"J Invest Dermatol"},{"key":"BF02134130_CR44","first-page":"169","volume-title":"The cancer cell","author":"T Sun","year":"1984","unstructured":"Sun T, Eichner R, Schermer A, Cooper D, Nelson WG, Weiss M (1984) Classification, expression and possible mechanism of evolution of mammalian epithelial keratins: a unifying model. In: Levine A, Topp W, Vande Woulde G, Watson JD (eds) The cancer cell. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 169\u2013176"},{"key":"BF02134130_CR45","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1073\/pnas.82.14.4683","volume":"82","author":"AL Tyner","year":"1985","unstructured":"Tyner AL, Eichman MJ, Fuchs E (1985) The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. Proc Natl Acad Sci USA 82:4683\u20134687","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134130_CR46","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0092-8674(82)90324-5","volume":"31","author":"Y-J Wu","year":"1982","unstructured":"Wu Y-J, Parker LM, Binder NE, Becket MA, Sinorol JH, Griffiths CT, Rheinwald JG (1982) The mesothelial keratins: a new family of cytoskeletal proteins identified in cultured mesothelial cells and nonkeratinizing epithelia. Cell 31:693\u2013703","journal-title":"Cell"},{"key":"BF02134130_CR47","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1093\/nar\/13.10.3723","volume":"13","author":"D Yaffe","year":"1985","unstructured":"Yaffe D, Nudel U, Mayer Y, Neuman S (1985) Highly conserved sequences in the 3\u2032 untranslated region of mRNAs coding for homologous proteins in distantly related species. Nucleic Acids Res 13:3723\u20133737","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02134130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02134130\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02134130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T13:18:27Z","timestamp":1626527907000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02134130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["BF02134130"],"URL":"https:\/\/doi.org\/10.1007\/bf02134130","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}