{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:19:15Z","timestamp":1775027955078,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1987,4,1]],"date-time":"1987-04-01T00:00:00Z","timestamp":544233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[1987,4]]},"DOI":"10.1007\/bf02134132","type":"journal-article","created":{"date-parts":[[2005,9,14]],"date-time":"2005-09-14T18:03:49Z","timestamp":1126721029000},"page":"337-345","source":"Crossref","is-referenced-by-count":202,"title":["Models of nearly neutral mutations with particular implications for nonrandom usage of synonymous codons"],"prefix":"10.1007","volume":"24","author":[{"given":"Wen-Hsiung","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02134132_CR1","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1016\/S0021-9258(19)81068-2","volume":"257","author":"JL Bennetzen","year":"1982","unstructured":"Bennetzen JL, Hall BD (1982) Codon selection in yeast. J Biol Chem 257:3026\u20133031","journal-title":"J Biol Chem"},{"key":"BF02134132_CR2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/genetics\/78.2.737","volume":"78","author":"J Felsenstein","year":"1974","unstructured":"Felsenstein J (1974) The evolutionary advantage of recombination. Genetics 78:737\u2013756","journal-title":"Genetics"},{"key":"BF02134132_CR3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0968-0004(80)90143-7","volume":"5","author":"R Grantham","year":"1980","unstructured":"Grantham R (1980) Workings of the genetic code. Trends Biochem Sci 5:327\u2013331","journal-title":"Trends Biochem Sci"},{"key":"BF02134132_CR4","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/nar\/8.9.1893","volume":"8","author":"R Grantham","year":"1980","unstructured":"Grantham R, Gautier C, Gouy M (1980) Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type. Nucleic Acids Res 8:1893\u20131912","journal-title":"Nucleic Acids Res"},{"key":"BF02134132_CR5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0378-1119(82)90157-3","volume":"18","author":"H Grosjean","year":"1982","unstructured":"Grosjean H, Fiers W (1982) Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes. Gene 18:199\u2013209","journal-title":"Gene"},{"key":"BF02134132_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-2836(81)90363-6","volume":"146","author":"T Ikemura","year":"1981","unstructured":"Ikemura T (1981) Correlation between the abundance ofEscherichia coli of the respective codons in its protein genes. J Mol Biol 146:1\u201321","journal-title":"J Mol Biol"},{"key":"BF02134132_CR7","first-page":"13","volume":"2","author":"T Ikemura","year":"1985","unstructured":"Ikemura T (1985) Codon usage and tRNA content in unicellular and multicellular organisms. Mol Biol Evol 2:13\u201334","journal-title":"Mol Biol Evol"},{"key":"BF02134132_CR8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/217624a0","volume":"217","author":"M Kimura","year":"1968","unstructured":"Kimura M (1968) Evolutionary rate at the molecular level. Nature 217:624\u2013626","journal-title":"Nature"},{"key":"BF02134132_CR9","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1073\/pnas.78.9.5773","volume":"78","author":"M Kimura","year":"1981","unstructured":"Kimura M (1981) Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons. Proc Natl Acad Sci USA 78:5773\u20135777","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134132_CR10","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511623486","volume-title":"The neutral theory of molecular evolution","author":"M Kimura","year":"1983","unstructured":"Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge, England"},{"key":"BF02134132_CR11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/229467a0","volume":"229","author":"M Kimura","year":"1971","unstructured":"Kimura M, Ohta T (1971) Protein polymorphism as a phase of molecular evolution. Nature 229:467\u2013469","journal-title":"Nature"},{"key":"BF02134132_CR12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.164.3881.788","volume":"164","author":"JL King","year":"1969","unstructured":"King JL, Jukes TH (1969) Non-Darwinian evolution. Science 164:788\u2013798","journal-title":"Science"},{"key":"BF02134132_CR13","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.74.6.2509","volume":"74","author":"WH Li","year":"1977","unstructured":"Li WH (1977) Maintenance of genetic variability under mutation and selection pressures in a finite population. Proc Natl Acad Sci USA 74:2509\u20132513","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02134132_CR14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/genetics\/95.1.237","volume":"95","author":"WH Li","year":"1980","unstructured":"Li WH (1980) Rate of gene silence at duplicate loci: a theoretical study and interpretation of data from tetraploid fishes. Genetics 95:237\u2013258","journal-title":"Genetics"},{"key":"BF02134132_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4684-4988-4_1","volume-title":"Molecular evolutionary genetics","author":"WH Li","year":"1985","unstructured":"Li WH, Luo CC, Wu CI (1985) Evolution of DNA sequences. In: MacIntyre RJ (ed) Molecular evolutionary genetics. Plenum, New York, pp 1\u201394"},{"key":"BF02134132_CR16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0027-5107(64)90047-8","volume":"1","author":"HJ Muller","year":"1964","unstructured":"Muller HJ (1964) The relation of recombination to mutational advance. Mutat Res 1:2\u20139","journal-title":"Mutat Res"},{"key":"BF02134132_CR17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0025-5564(85)90014-8","volume":"73","author":"P O'Brien","year":"1985","unstructured":"O'Brien P (1985) A genetic model with mutation and selection. Math Biosci 73:239\u2013251","journal-title":"Math Biosci"},{"key":"BF02134132_CR18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/252351a0","volume":"252","author":"T Ohta","year":"1974","unstructured":"Ohta T (1974) Mutational pressure as the main cause of molecular evolution and polymorphism. Nature 252:351\u2013354","journal-title":"Nature"},{"key":"BF02134132_CR19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1017\/S0016672300000690","volume":"2","author":"A Robertson","year":"1961","unstructured":"Robertson A (1961) Inbreeding in artificial selection programmes. Genet Res 2:189\u2013194","journal-title":"Genet Res"},{"key":"BF02134132_CR20","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1093\/nar\/12.17.6663","volume":"12","author":"M Robinson","year":"1984","unstructured":"Robinson M, Lilley R, Little S, Emtage JS, Yarranton G, Stephens P, Millican A, Eaton M, Humphreys G (1984) Codon usage can affect efficiency of translation of genes inEscherichia coli. Nucleic Acids Res 12:6663\u20136671","journal-title":"Nucleic Acids Res"},{"key":"BF02134132_CR21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF02100089","volume":"21","author":"PM Sharp","year":"1985","unstructured":"Sharp PM, Rogers MS, McConnell DJ (1985) Selection pressures on codon usage in the complete genome of bacteriophage T7. J Mol Evol 21:150\u2013160","journal-title":"J Mol Evol"},{"key":"BF02134132_CR22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/genetics\/85.4.789","volume":"85","author":"GA Watterson","year":"1977","unstructured":"Watterson GA (1977) Heterosis or neutrality. Genetics 85:789\u2013814","journal-title":"Genetics"},{"key":"BF02134132_CR23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/genetics\/16.2.97","volume":"16","author":"S Wright","year":"1931","unstructured":"Wright S (1931) Evolution in Mendelian populations. Genetics 16:97\u2013159","journal-title":"Genetics"},{"key":"BF02134132_CR24","first-page":"365","volume-title":"Genetics, paleontology and evolution","author":"S Wright","year":"1949","unstructured":"Wright S (1949) Adaptation and selection. In: Jepson GL, Simpson GG, Mayr E (eds) Genetics, paleontology and evolution. Princeton University Press, Princeton, pp 365\u2013389"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02134132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02134132\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02134132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T13:18:29Z","timestamp":1626527909000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02134132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["BF02134132"],"URL":"https:\/\/doi.org\/10.1007\/bf02134132","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}