{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:55:13Z","timestamp":1770501313323,"version":"3.49.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1991,2]]},"DOI":"10.1007\/bf02244194","type":"journal-article","created":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T23:37:37Z","timestamp":1132011457000},"page":"143-149","source":"Crossref","is-referenced-by-count":235,"title":["Serotonin, memory, and the aging brain"],"prefix":"10.1007","volume":"103","author":[{"given":"William J.","family":"McEntee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Crook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02244194_CR1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1471-4159.1983.tb11837.x","volume":"41","author":"SJ Allen","year":"1983","unstructured":"Allen SJ, Benton JS, Goodhardt MJ, Hann EA, Sims NR, Smith CCT, Spillane JA, Bowen DM, Davison AN (1983) Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain. J Neurochem 41:256\u2013265","journal-title":"J Neurochem"},{"key":"BF02244194_CR2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF00172866","volume":"90","author":"HJ Altman","year":"1986","unstructured":"Altman HJ, Normile HJ (1986) Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic anatgonists in mice. Psychopharmcology 90:24\u201327","journal-title":"Psychopharmcology"},{"key":"BF02244194_CR3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0197-4580(88)80124-6","volume":"9","author":"HJ Altman","year":"1988","unstructured":"Altman HJ, Normile HJ (1988) What is the nature of the role of the serotonergic nervous system in learning and memory: prospects for development of an effective treatment strategy for senile dementia. Neurobiol Aging 9:627\u2013638","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/BF00431456","volume":"84","author":"HJ Altman","year":"1984","unstructured":"Altman HJ, Nordy DA, Ogren SO (1984) Role of serotonin in memory: facilitation by alaproclate and zimeldine. Psychopharmacology 84:496\u2013502","journal-title":"Psychopharmacology"},{"key":"BF02244194_CR5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0163-1047(87)90574-7","volume":"48","author":"HJ Altman","year":"1987","unstructured":"Altman HJ, Stone WS, Ogren SO (1987) Evidence for a possible functional interaction between serotonergic and cholinergic mechanisms in memory retrieval. Behav Neural Biol 48:49\u201362","journal-title":"Behav Neural Biol"},{"key":"BF02244194_CR6","first-page":"725","volume":"14","author":"HJ Altman","year":"1988","unstructured":"Altman HJ, Normile HJ, Galloway MP, Ramirez T, Azmitia EC (1988) Facilitation of complex maze learning in rats following selective deafferentation of the dorsal hippocampus. Soc Neurosci Abstr 14:725","journal-title":"Soc Neurosci Abstr"},{"key":"BF02244194_CR7","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1471-4159.1984.tb00913.x","volume":"43","author":"H Arai","year":"1984","unstructured":"Arai H, Kosaka K, Iizuka T (1984) Changes of biogenic amines and their metabolites in postmortem brains from patients with Alzheimer-type dementia. J Neurochem 43:388\u2013393","journal-title":"J Neurochem"},{"key":"BF02244194_CR8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-2999(89)90519-0","volume":"173","author":"CR Ashby","year":"1990","unstructured":"Ashby CR, Edwards E, Harkins K, Wang RY (1990) Characterization of 5-hydroxytryptamine3, receptors in the rat medial prefrontal cortex. Eur J Pharmacol 173:193\u2013196","journal-title":"Eur J Pharmacol"},{"key":"BF02244194_CR9","first-page":"29","volume":"2","author":"MA Audet","year":"1989","unstructured":"Audet MA, Descarries L, Doucet G (1989) Quantified regional and laminar distribution of the serotonin innervation in the anterior half of adult rat cerebral cortex. J Chem Neuroanat 2:29\u201344","journal-title":"J Chem Neuroanat"},{"key":"BF02244194_CR10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(82)90041-0","volume":"6","author":"G Bammer","year":"1982","unstructured":"Bammer G (1982) Pharmacological investigations of neurotransmitter involved in passive avoidance responding: a review and some new results. Neurosci Biobehav Rev 6:247\u2013296","journal-title":"Neurosci Biobehav Rev"},{"key":"BF02244194_CR11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0006-8993(87)90574-9","volume":"419","author":"A Baskys","year":"1987","unstructured":"Baskys A, Niesen CE, Carlen PL (1987) Altered modulatory actions of serotonin on dentate granule cells of aged rats. Brain Res 419:112\u2013118","journal-title":"Brain Res"},{"key":"BF02244194_CR12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1471-4159.1983.tb11838.x","volume":"41","author":"DN Bowen","year":"1983","unstructured":"Bowen DN, Allen SJ, Benton JS, Goodhardt MJ, Hann EA, Palmer AM, Sims NR, Smith CCT, Spillane JA, Esiri MM, Neary D, Snowdon JS, Wilcock GK, Davison AN (1983) Biochemical assessment of sertonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease. J Neurochem 41:266\u2013272","journal-title":"J Neurochem"},{"key":"BF02244194_CR13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF00402088","volume":"17","author":"JF Brody","year":"1978","unstructured":"Brody JF (1978) Behavioral effects of serotonin depletion and ofp-chlorophenylalanine (a serotonin depletor) in rats. Psychopharmacology 17:14\u201333","journal-title":"Psychopharmacology"},{"key":"BF02244194_CR14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-0773.1988.tb00930.x","volume":"63","author":"N Brunello","year":"1988","unstructured":"Brunello N, Riva M, Rovescalli AC, Galimberti R, Racasni G (1988) Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment. Pharmacol Toxicol 63:150\u2013155","journal-title":"Pharmacol Toxicol"},{"key":"BF02244194_CR15","unstructured":"Costall B, Domeney AM, Gerrard PA, Jones DNC, Naylor RJ, Tyers MB (1989a) Effects of GR38032F on performance of common marmosets (Callithrix jacchus) in an object discrimination reversal task. Br J Phamracol [Suppl] 98:637P"},{"key":"BF02244194_CR16","unstructured":"Costall B, Coughlan J, Kelly ME, Naylor RJ, Tyers MB (1989b) Scopolamine-induced deficits in a T-maze reinforced alternation task are attenuated by 5-HT3 receptor antagonists. Br J Pharmacol [Suppl] 98:636P"},{"key":"BF02244194_CR17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0006-8993(80)91298-6","volume":"191","author":"F Crespi","year":"1980","unstructured":"Crespi F, Buda M, McRae-Degueurce A, Pujol JF (1980) Alteration of tyrosine hydroxylase activity in the locus coeruleus after administration ofp-chlorophenylalanine. Brain Res 191:501\u2013509","journal-title":"Brain Res"},{"key":"BF02244194_CR18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/87565648609540348","volume":"2","author":"T Crook","year":"1986","unstructured":"Crook T, Bartus RT, Ferris SH, Whitehouse P, Cohen GD, Gershon S (1986) Age-associated memory impairment. Proposed diagnostic criteria and measures of clinical change: report of a National Institute of Health work group. Dev Neuropsychol 2:261\u2013276","journal-title":"Dev Neuropsychol"},{"key":"BF02244194_CR19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00005072-198407000-00001","volume":"43","author":"CA Curcio","year":"1984","unstructured":"Curcio CA, Kemper T (1984) Nucleus raphe dorsalis in dementia of the Alzheimer type; neurofibrillary changes and neuronal packing density. J Neuropathol Exp Neurol 43:359\u2013368","journal-title":"J Neuropathol Exp Neurol"},{"key":"BF02244194_CR20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0197-4580(87)90036-4","volume":"8","author":"A Ebel","year":"1987","unstructured":"Ebel A, Strosser HT, Kempf E (1987) Genotypic differences in central neurotransmitter responses to aging in mice. Neurobiol Aging 8:417\u2013427","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR21","first-page":"69","volume-title":"Serotonin in health and disease","author":"WB Essman","year":"1978","unstructured":"Essman WB (1978) Serotonin in learning and memory. In: Essman WB (ed) Serotonin in health and disease. Spectrum, New York, pp 69\u2013143"},{"key":"BF02244194_CR22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0014-2999(77)90321-1","volume":"41","author":"D Euvard","year":"1977","unstructured":"Euvard D, Javoy F, Herbert A, Glowinski J (1977) Effect of quipazine, a serotonin-like drug, on striatal cholinergic interneurons. Eur J Pharmacol 41:281\u2013289","journal-title":"Eur J Pharmacol"},{"key":"BF02244194_CR23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF02439584","volume":"93","author":"JF Flood","year":"1987","unstructured":"Flood JF, Cherkin A (1987) Fluoxetine enhances memory processing in mice. Psychopharmacology 93:36\u201343","journal-title":"Psychopharmacology"},{"key":"BF02244194_CR24","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1471-4159.1985.tb10523.x","volume":"45","author":"G Gillet","year":"1985","unstructured":"Gillet G, Ammor S, Fillion G (1985) Serotonin inhibits acetylcholine release from rat striatum slices: evidence for a presynaptic receptor-mediated effect. J Neurochem 45:1687\u20131691","journal-title":"J Neurochem"},{"key":"BF02244194_CR25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0197-4580(89)90029-8","volume":"10","author":"F Godefroy","year":"1989","unstructured":"Godefroy F, Bassant MH, Weil-Fugazza J, Lamour Y (1989) Age-related changes in dopaminergic and serotonergic indices in the rat forebrain. Neurobiol Aging 10:187\u2013190","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0197-4580(83)90002-7","volume":"4","author":"C-G Gottfries","year":"1983","unstructured":"Gottfries C-G, Adolfsson R, Aquilonius S-M, Carlsson A, Eckernas A, Nordberg A, Oreland L, Svennerholm L, Wiberg A, Winblad B (1983) Biochemical changes in dementia disorders of Alzheimer type. Neurobiol Aging 4:261\u2013271","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0091-3057(78)90309-X","volume":"8","author":"C Kohler","year":"1978","unstructured":"Kohler C, Lorens SA (1978) Open field activity and avoidance behavior following serotonin depletion: a comparison of the effects of parachlorophenylalanine and electrolytic midbrain raphe lesions. Pharmacol Biochem Behav 8:223\u2013233","journal-title":"Pharmacol Biochem Behav"},{"key":"BF02244194_CR28","first-page":"257","volume":"86","author":"VA Kral","year":"1962","unstructured":"Kral VA (1962) Senescent forgetfulness: benign and malignant. J Can Med Assoc 86:257\u2013260","journal-title":"J Can Med Assoc"},{"key":"BF02244194_CR29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0166-4328(88)90171-4","volume":"30","author":"T Kubo","year":"1988","unstructured":"Kubo T, Shibanoki S, Matsumoto A, Tsuda K, Ishikawa K (1988) Portacaval anastomosis attenuates the impairing effect of cypropheptadine on avoidance learning in rats \u2014 an involvement of the serotonergic system. Behav Brain Res 30:279\u2013287","journal-title":"Behav Brain Res"},{"key":"BF02244194_CR30","first-page":"289","volume-title":"Cholinergic mechanisms: phylogenetic aspects, central and peripheral synapses and clinical significance. Advances in behavioral biology, vol 25","author":"H Ladinski","year":"1981","unstructured":"Ladinski H, Consolo S, Tirelli AS, Forloni GL, Segal M (1981) Regulation of chlonergic activity in the rat hippocampus: in vivo effects of oxotremorine and fenfluramine. In: Pepeu G, Ladinski H (eds) Cholinergic mechanisms: phylogenetic aspects, central and peripheral synapses and clinical significance. Advances in behavioral biology, vol 25. Plenum, New York, pp 289\u2013296"},{"key":"BF02244194_CR31","first-page":"365","volume-title":"Clinical and abnormal psychology","author":"F Lane","year":"1989","unstructured":"Lane F, Snowden F (1989) Memory and dementia: a longitudinal survey of suburban elderly. In: Lovibond P, Wilson P (eds) Clinical and abnormal psychology. Elsevier, North-Holland, pp 365\u2013376"},{"key":"BF02244194_CR32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0006-8993(87)91284-4","volume":"421","author":"PJ Langlais","year":"1987","unstructured":"Langlais PJ, Mair RG, Anderson CD, McEntee WJ (1987) Monoamines and metabolites in cortex and subcortical structures: normal regional distribution and the effects of thiamine deficiency in the rat. Brain Res 421:140\u2013149","journal-title":"Brain Res"},{"key":"BF02244194_CR33","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/archpsyc.1989.01810060064010","volume":"46","author":"BA Lawlor","year":"1989","unstructured":"Lawlor BA, Sunderland T, Mellow AM, Hill JL, Molchan SE, Murphy DL (1989a) Hyperresponsivity to the serotonin agonistm-chlorophenylpiperazine in Alzheimer's disease. Arch Gen Psychiatry 46:542\u2013549","journal-title":"Arch Gen Psychiatry"},{"key":"BF02244194_CR34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0006-3223(89)90237-0","volume":"25","author":"BA Lawlor","year":"1989","unstructured":"Lawlor BA, Sunderland T, Mellow AM, Hill JL, Newhouse PA, Murphy DL (1989b) A preliminary study of the effects of intravenousm-chlorophenylpiperazine, a serotonin agonist, in elderly subjects. Biol Psychiatry 25:679\u2013686","journal-title":"Biol Psychiatry"},{"key":"BF02244194_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(78)90791-6","volume":"145","author":"L Leger","year":"1978","unstructured":"Leger L, Descarries L (1978) Serotonin nerve terminals in the locus coeruleus of adult rat. A radioautographic study. Brain Res 145:1\u201313","journal-title":"Brain Res"},{"key":"BF02244194_CR36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-8993(76)90190-6","volume":"108","author":"BD Lewis","year":"1976","unstructured":"Lewis BD, Renaud B, Buda M, Pujol JF (1976) Time-course variation in tyrosine hydroxylase activity in the rat locus coeruleus after electrolytic destruction of the nucleus raphe dorsalis or raphe centralis. Brain Res 108:339\u2013344","journal-title":"Brain Res"},{"key":"BF02244194_CR37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0166-4328(85)90179-2","volume":"15","author":"RG Mair","year":"1985","unstructured":"Mair RG, McEntee WJ, Zatorre RJ (1985a) monoamine activity correlates with psychometric deficits in Korsakoff's disease. Behav Brain Res 15:247\u2013254","journal-title":"Behav Brain Res"},{"key":"BF02244194_CR38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0006-8993(85)91243-0","volume":"360","author":"RG Mair","year":"1985","unstructured":"Mair RG, Anderson CD, Langlais PJ, McEntee WJ (1985b) Thiamine deficiency depletes cortical norepinephrine and impairs learning processes in the rat. Brain Res 360:273\u2013284","journal-title":"Brain Res"},{"key":"BF02244194_CR39","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0014-2999(86)90446-2","volume":"129","author":"M Marchi","year":"1986","unstructured":"Marchi M, Paudice P, Bella M, Raiteri M (1986) Dicyclomine-and pirenzapine-sensitive muscarinic receptors mediate inhibition of3H-serotonin release in different rat brain areas. Eur J Pharmacol 129:353\u2013357","journal-title":"Eur J Pharmacol"},{"key":"BF02244194_CR40","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1111\/j.1471-4159.1984.tb06098.x","volume":"43","author":"J Marcusson","year":"1984","unstructured":"Marcusson J, Oreland L, Winblad B (1984a) Effect of age on human brain serotonin (S-1) binding sites. J Neurochem 43:1699\u20131705","journal-title":"J Neurochem"},{"key":"BF02244194_CR41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0006-8993(84)91397-0","volume":"311","author":"JO Marcusson","year":"1984","unstructured":"Marcusson JO, Morgon DG, Winblad B, Finch CE (1984b) Serotonin-2 binding sites in human frontal cortex and hippocampus. Selective loss of S-2A sites with age. Brain Res 311:51\u201356","journal-title":"Brain Res"},{"key":"BF02244194_CR42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0006-8993(87)90492-6","volume":"425","author":"JO Marcusson","year":"1987","unstructured":"Marcusson JO, Alafuzoff I, Backstrom IT, Ericson E, Gottfries CG, Winblad B (1987) 5-Hydroxytryptamine-sensitive3H-imipramine binding of protein nature in the human brain. II. Effect of normal aging and dementia disorders. Brain Res 425:137\u2013145","journal-title":"Brain Res"},{"key":"BF02244194_CR43","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1212\/WNL.34.7.966","volume":"34","author":"PR Martin","year":"1984","unstructured":"Martin PR, Higa S, Burns RS, Tamarkin L, Ebert MH, Markey SP (1984a) Decreased 6-hydroxymelatonin excretion in Korsakoff's psychosis. Neurology 34:966\u2013968","journal-title":"Neurology"},{"key":"BF02244194_CR44","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ana.410150212","volume":"15","author":"PR Martin","year":"1984","unstructured":"Martin PR, Weingartner H, Gordon EK, Burns S, Linnoila M, Kopin IJ, Ebert MH (1984b) Central nervous system catecholamine metabolism in Korsakoff's psychosis. Ann Neurol 15:184\u2013187","journal-title":"Ann Neurol"},{"key":"BF02244194_CR45","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1212\/WNL.36.3.411","volume":"36","author":"PR Martin","year":"1986","unstructured":"Martin PR, Lowenstein RJ, Kaye WH, Ebert MH, Weingartner H, Gillin JC (1986) Sleep EEG in Korsakoff's psychosis and Alzheimer's disease. Neurology 36:411\u2013414","journal-title":"Neurology"},{"key":"BF02244194_CR46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.1989.01810070043008","volume":"46","author":"PR Martin","year":"1989","unstructured":"Martin PR, Adinoff B, Eckardt MJ, Stapleton JM, Bone GAH, Rubinow DR, Lane EA, Linnoila M (1989) Effective pharmacotherpay of alcoholic amnestic disorder with fluvoxamine. Arch Gen Psychiatry 46:617\u2013621","journal-title":"Arch Gen Psychiatry"},{"key":"BF02244194_CR47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0014-2999(86)90443-7","volume":"129","author":"G Marua","year":"1986","unstructured":"Marua G, Raiteri M (1986) Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. Eur J Pharmacol 129:333\u2013337","journal-title":"Eur J Pharmacol"},{"key":"BF02244194_CR48","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1212\/WNL.40.3_Part_1.526","volume":"40","author":"WJ McEntee","year":"1990","unstructured":"McEntee WJ, Crook TH (1990) Age-associated memory impairment: a role for catecholamines. Neurology 40:526\u2013530","journal-title":"Neurology"},{"key":"BF02244194_CR49","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/ana.410070513","volume":"7","author":"WJ McEntee","year":"1980","unstructured":"McEntee WJ, Mair RG (1980) Memory enhancement in Korskoff's psychosis with clonidine: further evidence for a noradrenergic deficit. Ann Neurol 7:466\u2013470","journal-title":"Ann Neurol"},{"key":"BF02244194_CR50","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1212\/WNL.34.5.648","volume":"34","author":"WJ McEntee","year":"1984","unstructured":"McEntee WJ, Mair RG, Langlais PJ (1984) Neurochemical pathology in Korsakoff's psychosis: implications for other cognitive disorders. Neurology 34:648\u2013652","journal-title":"Neurology"},{"key":"BF02244194_CR51","first-page":"158","volume":"344","author":"A McRae-Degueurce","year":"1985","unstructured":"McRae-Degueurce A, Dennis T, Leger L, Scatton B (1985) Regulation of neuronal activity in the rat locus coeruleus by serotonergic afferents. Physiol Psychol 344:158\u2013161","journal-title":"Physiol Psychol"},{"key":"BF02244194_CR52","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1471-4159.1986.tb13069.x","volume":"46","author":"DN Middlemiss","year":"1986","unstructured":"Middlemiss DN, Palmer AM, Edel N, Bowen DM (1986) Binding of the novel serotonin agonist 8-hydroxy-2(di-n-propylamino) tetralin in normal and Alzheimer brain. J Neurochem 46:993\u2013996","journal-title":"J Neurochem"},{"key":"BF02244194_CR53","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/BF00970933","volume":"12","author":"A Moretti","year":"1987","unstructured":"Moretti A, Carfagna N, Trunzo F (1987) Effect of aging on monoamines and their metabolites in the rat brain. Neurochem Res 12:1035\u20131039","journal-title":"Neurochem Res"},{"key":"BF02244194_CR54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-8993(88)90163-1","volume":"453","author":"OG Nilsson","year":"1988","unstructured":"Nilsson OG, Strecker RE, Daszuta A, Bjorklund A (1988) Combined cholinergic and serotonergic denervation of the forebrain produces severe deficits in a spatial learning task in the rat. Brain Res 453:235\u2013246","journal-title":"Brain Res"},{"key":"BF02244194_CR55","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/BF00210849","volume":"92","author":"HJ Normile","year":"1987","unstructured":"Normile HJ, Altman HJ (1987) Evidence for a possible interaction between noradrenergic and serotonergic transmission in the retrieval of a previously learned aversive habit in mice. Psychopharmacology 92:388\u2013392","journal-title":"Psychopharmacology"},{"key":"BF02244194_CR56","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0197-4580(88)80084-8","volume":"9","author":"HJ Normile","year":"1988","unstructured":"Normile HJ, Altman HJ (1988) Enhanced passive avoidance retention following posttrain serotonergic receptor antagonist administration in middle-aged and aged rats. Neurobiol Aging 9:377\u2013382","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR57","first-page":"465","volume":"15","author":"HJ Normile","year":"1989","unstructured":"Normile HJ, Jenden DJ, Kuhn DM, Wolf WA, Altman HJ (1989) Effects of combined serotonin depletion and lesions of the nucleus basalis magnocellularis on acquisition of a complex spatial discrimination task. Soc Neurosci Abstr 15:465","journal-title":"Soc Neurosci Abstr"},{"key":"BF02244194_CR58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0306-4522(90)90301-J","volume":"34","author":"S Oleskevich","year":"1990","unstructured":"Oleskevich S, Descarries L (1990) Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience 34:19\u201333","journal-title":"Neuroscience"},{"key":"BF02244194_CR59","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1471-4159.1987.tb13120.x","volume":"8","author":"AM Palmer","year":"1987","unstructured":"Palmer AM, Francis PT, Benton JS, Sims NR, Mann DMA, Neary D, Snowden JS, Bown DM (1987) Presynaptic serotonergic dysfunction in patients with Alzheimer's disease. J Neurochem 8:8\u201315","journal-title":"J Neurochem"},{"key":"BF02244194_CR60","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1212\/WNL.28.7.691","volume":"23","author":"A Plaitakis","year":"1978","unstructured":"Plaitakis A, Nicklas WJ, Berl S (1978) Thiamine deficiency: selective impairment of the cerebellar serotonergic system. Neurology 23:691\u2013698","journal-title":"Neurology"},{"key":"BF02244194_CR61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0197-4580(82)90057-4","volume":"3","author":"F Ponzio","year":"1982","unstructured":"Ponzio F, Calderini G, Lomuscio G, Vantini G, Toffano G, Algeri S (1982) Changes in monoamines and their metabolite levels in some brain regions of aged rats. Neurobiol Aging 3:23\u201329","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR62","first-page":"465","volume":"15","author":"TM Ramirez","year":"1989","unstructured":"Ramirez TM, Altman HJ, Normile HJ, Kuhn DM, Azmitia EC (1989) The effects of serotonergic intrahippocampal neonatal grafts on learning and memory in the Stone 14-unit T-maze. Soc Neurosci Abstr 15:465","journal-title":"Soc Neurosci Abstr"},{"key":"BF02244194_CR63","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0006-8993(85)91202-8","volume":"344","author":"A Rappaport","year":"1985","unstructured":"Rappaport A, Sturtz F, Guicheney P (1985) Regulation of central alpha adrenoceptors by serotonergic denervation. Brain Res 344:158\u2013161","journal-title":"Brain Res"},{"key":"BF02244194_CR64","first-page":"195","volume-title":"Monoamine innervation of cerebral cortex","author":"TA Reader","year":"1984","unstructured":"Reader TA, Jasper HH (1984) Interaction between monoamines and other transmitters in cerebral cortex. In: Descarries L, Reader TR, Jasper HH (eds) Monoamine innervation of cerebral cortex. Liss, New York, pp 195\u2013225"},{"key":"BF02244194_CR65","first-page":"535","volume-title":"Williams textbook of endocrinology","author":"S Reichlin","year":"1985","unstructured":"Reichlin S (1985) The pineal. In: Wilson JD, Foster DW (eds), Williams textbook of endocrinology. Saunders, Philadelphia, pp 535\u2013538"},{"issue":"Suppl 1","key":"BF02244194_CR66","first-page":"177","volume":"40","author":"KJ Reinikainen","year":"1990","unstructured":"Reinikainen KJ, Koivisto K, Mykkanen L, Hanninen T, Laakso M, Pyorala K, Riekkinen PJ (1990) Age-associated memory impairment in aged population: an epidemiological study. Neurology [Suppl 1] 40:177","journal-title":"Neurology"},{"key":"BF02244194_CR67","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0024-3205(83)90080-2","volume":"32","author":"SE Robinson","year":"1983","unstructured":"Robinson SE (1983) Effect of specific serotonergic lesions on cholinergic neurons in the hippocampus, cortex and striatum. Life Sci 32:345\u2013353","journal-title":"Life Sci"},{"key":"BF02244194_CR68","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/oxfordjournals.bmb.a072101","volume":"42","author":"M Rossor","year":"1986","unstructured":"Rossor M, Iversen LL (1986) Non-cholinergic neurotransmitter abnormalities in Alzheimer's disease. Br Med Bull 42:70\u201374","journal-title":"Br Med Bull"},{"key":"BF02244194_CR69","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0006-8993(78)90951-4","volume":"151","author":"R Samanin","year":"1978","unstructured":"Samanin R, Quattrone A, Perri G, Ladinski H, Consolo S (1978) Evidence for an interaction between serotonergic and cholinergic neurons in the corpus striatum and hippocampus of the rat brain. Brain Res 151:73\u201382","journal-title":"Brain Res"},{"key":"BF02244194_CR70","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1096\/fasebj.3.11.2673898","volume":"3","author":"AW Schmidt","year":"1989","unstructured":"Schmidt AW, Peroutka SJ (1989) 5-hydroxytryptamine receptor families. FASEB J 3:2242\u20132249","journal-title":"FASEB J"},{"key":"BF02244194_CR71","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cne.902890111","volume":"289","author":"P Seguela","year":"1989","unstructured":"Seguela P, Watkins KC, Descarries L (1989) Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of adult rat. J Comp Neurol 289:129\u2013142","journal-title":"J Comp Neurol"},{"key":"BF02244194_CR72","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0197-4580(86)90144-2","volume":"7","author":"JA Severson","year":"1986","unstructured":"Severson JA (1986)3H-Imipramine binding in aged mouse brain: regulation by ions and serotonin. Neurobiol Aging 7:83\u201387","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR73","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/j.1471-4159.1985.tb07203.x","volume":"45","author":"JA Severson","year":"1985","unstructured":"Severson JA, Marcusson JO, Osterburg HH, Finch CE, Winblad B (1985) Elevated density of3H-imipramine binding in aged human brain. J Neurochem 45:1382\u20131389","journal-title":"J Neurochem"},{"key":"BF02244194_CR74","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/0024-3205(78)90125-X","volume":"23","author":"JC Shih","year":"1978","unstructured":"Shih JC, Young H (1978) The alteration of serotonin binding sites in aged human brain. Life Sci 23:1441\u20131448","journal-title":"Life Sci"},{"key":"BF02244194_CR75","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1210\/endo-100-6-1672","volume":"100","author":"JW Simpkins","year":"1977","unstructured":"Simpkins JW, Mueller GP, Huang HH, Meites J (1977) Evidence for depressed catecholamine and enhanced serotonin metabolism in ageing male rats. Endocrinology 100:1672\u20131678","journal-title":"Endocrinology"},{"key":"BF02244194_CR76","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/0024-3205(85)90242-5","volume":"37","author":"M Stanley","year":"1985","unstructured":"Stanley M, Traskman-Bendz L, Dorovini ZK (1985) Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 37:1279\u20131286","journal-title":"Life Sci"},{"key":"BF02244194_CR77","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0091-3057(89)90456-5","volume":"33","author":"KF Strek","year":"1989","unstructured":"Strek KF, Spencer KR, DeNoble VJ (1989) Manipulation of serotonin protects against an hypoxia-induced deficit of a passive avoidance response in rats. Pharmacol Biochem Behav 33:241\u2013244","journal-title":"Pharmacol Biochem Behav"},{"key":"BF02244194_CR78","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-8993(84)90514-6","volume":"296","author":"JB Thurmond","year":"1984","unstructured":"Thurmond JB, Brown JW (1984) Effect of brain monoamine precursors on stress-induced behavioral and neurochemical changes in aged mice. Brain Res 296:93\u2013102","journal-title":"Brain Res"},{"key":"BF02244194_CR79","first-page":"173","volume-title":"The aging brain: cellular and molecular mechanisms of aging in the central nervous system. Aging, vol 20","author":"PS Timras","year":"1982","unstructured":"Timras PS, Hudson DB, Miller C (1982) Developing and aging brain serotonergic systems. In: Giacobini E, Filogamo G, Giacobini G, Vernadakis A (eds) The aging brain: cellular and molecular mechanisms of aging in the central nervous system. Aging, vol 20. Raven Press, New York, pp 173\u2013184"},{"key":"BF02244194_CR80","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000117673","volume":"5","author":"L Valzelli","year":"1979","unstructured":"Valzelli L, Pawlowski L (1979) Effect ofp-chlorophenylalanine on avoidance learning of two differentially housed mouse strains. Neuropsychobiology 5:121\u2013128","journal-title":"Neuropsychobiology"},{"key":"BF02244194_CR81","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0006-8993(79)90494-3","volume":"179","author":"MH Woert Van","year":"1979","unstructured":"Van Woert MH, Plaitakis A, Hwang EC, Berl S (1979) Effect of thiamine deficiency on brain serotonin turnover. Brain Res 179:103\u2013110","journal-title":"Brain Res"},{"key":"BF02244194_CR82","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.6223371","volume":"221","author":"H Weingartner","year":"1983","unstructured":"Weingartner H, Rudorfer MV, Buchsbaum MS, Linnoila M (1983) Effects of serotonin on memory impairments produced by ethanol. Science 221:472\u2013474","journal-title":"Science"},{"key":"BF02244194_CR83","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0197-4580(84)90063-0","volume":"5","author":"P Wester","year":"1984","unstructured":"Wester P, Hardy JA, Marcusson J, Nybers P, Winblad B (1984) Serotonin concentrations in normal aging human brains: relation to serotonin receptors. Neurobiol Aging 5:199\u2013203","journal-title":"Neurobiol Aging"},{"key":"BF02244194_CR84","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0091-3057(80)90378-0","volume":"12","author":"W Wetzel","year":"1980","unstructured":"Wetzel W, Getsova VM, Jork R, Matthies H (1980) Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats. Phrmacol Biochem Behav 12:319\u2013322","journal-title":"Phrmacol Biochem Behav"},{"key":"BF02244194_CR85","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0091-3057(87)90184-5","volume":"27","author":"JC Winter","year":"1987","unstructured":"Winter JC, Petti DT (1987) The effects of 8-hydroxy-2-(di-n-propylamino) tetralin and other serotonergic agonists on performance in a radial maze: a possible role for 5-HT1A receptors in memory. Pharmacol Biochem Behav 27:625\u2013628","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02244194.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02244194\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02244194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T19:31:58Z","timestamp":1557862318000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02244194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["BF02244194"],"URL":"https:\/\/doi.org\/10.1007\/bf02244194","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2]]}}}