{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:12:39Z","timestamp":1773425559295,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1991,2,1]],"date-time":"1991-02-01T00:00:00Z","timestamp":665366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1991,2]]},"DOI":"10.1007\/bf02244208","type":"journal-article","created":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T04:37:37Z","timestamp":1132029457000},"page":"227-232","source":"Crossref","is-referenced-by-count":285,"title":["CRF antagonist reverses the \u201canxiogenic\u201d response to ethanol withdrawal in the rat"],"prefix":"10.1007","volume":"103","author":[{"given":"Helen A.","family":"Baldwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Rassnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Rivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George F.","family":"Koob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen T.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02244208_CR1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0167-0115(86)90031-5","volume":"16","author":"KT Britton","year":"1986","unstructured":"Britton KT, Koob GF (1986) Alcohol reverses the proconflict effect of corticotropin-releasing factor. Regul Pept 16:315\u2013320","journal-title":"Regul Pept"},{"key":"BF02244208_CR2","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/0024-3205(86)90189-X","volume":"39","author":"KT Britton","year":"1986","unstructured":"Britton KT, Lee G, Dana R, Risch SC, Koob GF (1986a) Activating and \u201canxiogenic\u201d effects of CRF are not inhibited by blockade of the pituitary adrenal system with dexamethasone. Life Sci 39:1281\u20131286","journal-title":"Life Sci"},{"key":"BF02244208_CR3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(86)90539-1","volume":"369","author":"KT Britton","year":"1986","unstructured":"Britton KT, Lee G, Vale W, Rivier J, Koob GF (1986b) Corticotropin releasing factor antagonists block activating and \u201canxiogenic\u201d actions of CRF in the rat. Brain Res 369:303\u2013306","journal-title":"Brain Res"},{"key":"BF02244208_CR4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1530-0277.1977.tb05761.x","volume":"1","author":"H Cappel","year":"1977","unstructured":"Cappel H, Herman CP (1977) Alcohol and tension reduction. Q J Stud Alcohol 1:21\u201329","journal-title":"Q J Stud Alcohol"},{"key":"BF02244208_CR5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0018-506X(87)90044-4","volume":"21","author":"AJ Dunn","year":"1987","unstructured":"Dunn AJ, File SE (1987) Corticotropin-releasing factor has a anxiogenic action in the social interaction test. Horm Behav 21:193\u2013202","journal-title":"Horm Behav"},{"key":"BF02244208_CR6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0196-9781(85)90323-7","volume":"6","author":"M Eaves","year":"1985","unstructured":"Eaves M, Britton KT, Rivier J, Vale W, Koob GF (1985) Effects of corticotropin releasing factor on locomotor activity in hypophysectomized rats. Peptides 6:923\u2013926","journal-title":"Peptides"},{"key":"BF02244208_CR7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0167-0115(87)90176-5","volume":"19","author":"CL Ehlers","year":"1987","unstructured":"Ehlers CL, Chaplin RI (1987) Chronic ethanol exposure potentiates the locomotor activating effects of corticotropin-releasing factor (CRF) in rats. Regul Pept 19:345\u2013354","journal-title":"Regul Pept"},{"key":"BF02244208_CR8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/smi.2460040407","volume":"4","author":"SE File","year":"1988","unstructured":"File SE, Johnston AL, Baldwin HA (1988) Anxiolytic and anxiogenic drugs: changes in behavior and endocrine responses. Stress Medicine 4:221\u2013230","journal-title":"Stress Medicine"},{"key":"BF02244208_CR9","first-page":"252","volume":"98","author":"SE File","year":"1989","unstructured":"File SE, Baldwin HA, Hitchcott PK (1989) Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat. Psychopharmacology 98:252\u2013264","journal-title":"Psychopharmacology"},{"key":"BF02244208_CR10","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1126\/science.172.3980.288","volume":"172","author":"DB Goldstein","year":"1971","unstructured":"Goldstein DB, Pal N (1971) Alcohol dependence produced in mice by inhalation: grading the withdrawal reaction. Science 172:288\u2013290","journal-title":"Science"},{"key":"BF02244208_CR11","first-page":"173","volume":"90","author":"GF Koob","year":"1986","unstructured":"Koob GF, Braestrup C, Thatcher-Britton K (1986) The effects of FG 7142 and RO 15-1788 on the release of punished responding produced by chlordiazepoxide and ethanol. Psychopharmacology 90:173\u2013178","journal-title":"Psychopharmacology"},{"key":"BF02244208_CR12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0091-3057(86)90552-6","volume":"24","author":"S Pellow","year":"1986","unstructured":"Pellow S, File SE (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24:525\u2013529","journal-title":"Pharmacol Biochem Behav"},{"key":"BF02244208_CR13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","volume":"14","author":"S Pellow","year":"1985","unstructured":"Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149\u2013167","journal-title":"J Neurosci Methods"},{"key":"BF02244208_CR14","first-page":"127","volume":"229","author":"C Rivier","year":"1984","unstructured":"Rivier C, Bruhn T, Vale W (1984a) Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF). J Pharmacol Exp Ther 229:127\u2013131","journal-title":"J Pharmacol Exp Ther"},{"key":"BF02244208_CR15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1126\/science.6289439","volume":"218","author":"C Rivier","year":"1982","unstructured":"Rivier C, Rivier J, Vale W (1982) Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor. Science 218:388\u2013378","journal-title":"Science"},{"key":"BF02244208_CR16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.6326264","volume":"224","author":"J Rivier","year":"1984","unstructured":"Rivier J, Rivier C, Vale W (1984b) Synthetic competetive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science 224:889\u2013891","journal-title":"Science"},{"key":"BF02244208_CR17","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","volume":"213","author":"W Vale","year":"1981","unstructured":"Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41 residue ovine hypothalamic peptide that stimulates the secretion of corticotropin and beta-endorphin. Science 213:1394\u20131397","journal-title":"Science"},{"key":"BF02244208_CR18","first-page":"23","volume-title":"Stress and alcohol use","author":"D Thiel Van","year":"1983","unstructured":"Van Thiel D (1983) Adrenal response to ethanol: a stress response. In: Pohorecky LA, Brick J (eds) Stress and alcohol use. Elsevier, Amsterdam, pp 23\u201327"},{"key":"BF02244208_CR19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1037\/h0023299","volume":"3","author":"AF Williams","year":"1966","unstructured":"Williams AF (1966) Social drinking, anxiety and depression. J Pers Soc Psychol 3:689\u2013693","journal-title":"J Pers Soc Psychol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02244208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02244208\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02244208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T23:31:58Z","timestamp":1557876718000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02244208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["BF02244208"],"URL":"https:\/\/doi.org\/10.1007\/bf02244208","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,2]]}}}