{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:10:39Z","timestamp":1767859839444,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[1992,5]]},"DOI":"10.1007\/bf02244958","type":"journal-article","created":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T17:22:31Z","timestamp":1131988951000},"page":"1-10","source":"Crossref","is-referenced-by-count":74,"title":["Fluoxetine: a review of receptor and functional effects and their clinical implications"],"prefix":"10.1007","volume":"107","author":[{"given":"Charles M.","family":"Beasley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel N.","family":"Masica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet H.","family":"Potvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02244958_CR1","first-page":"221","volume":"36","author":"J Arnt","year":"1984","unstructured":"Arnt J, Hyttel J, Overo K (1984) Prolonged treatment with the specific 5-HT-uptake inhibitor citalopram: effect on dopaminergic and serotonergic functions. Pol J Pharmacol Pharm 36:221\u2013230","journal-title":"Pol J Pharmacol Pharm"},{"key":"BF02244958_CR2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/archpsyc.1990.01810140091015","volume":"47","author":"R Baldessarini","year":"1990","unstructured":"Baldessarini R, Marsh E (1990) Fluoxetine and side effects (letter). Arch Gen Psychiatry 47:191\u2013192","journal-title":"Arch Gen Psychiatry"},{"key":"BF02244958_CR3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-2999(88)90089-1","volume":"154","author":"B Baron","year":"1988","unstructured":"Baron B, Ogden A, Siegel B, Stegeman J, Ursillo R, Dudley M (1988) Rapid downregulation of beta-adrenoceptors by coadministration of desipramine and fluoxetine. Eur J Pharmacol 154:125\u2013134","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BFb0034294","volume":"70","author":"H Blaschko","year":"1974","unstructured":"Blaschko H (1974) The natural history of amine oxidases. Rev Physiol Biochem Pharmacol 70:83\u2013148","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"BF02244958_CR5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF00168834","volume":"337","author":"P Blier","year":"1988","unstructured":"Blier P, Chaput Y, deMontigny C (1988) Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Arch Pharmacol 337:246\u2013254","journal-title":"Arch Pharmacol"},{"key":"BF02244958_CR6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00735896","volume":"94","author":"WF Byerley","year":"1988","unstructured":"Byerley WF, McConnell EJ, McCabe RT, Dawson TM, Grosser BI, Wamsley JK (1988) Decreased beta-adrenergic receptors in rat brain after chronic administration of the selective serotonin uptake inhibitor fluoxetine. Psychopharmacology 94:141\u2013143","journal-title":"Psychopharmacology"},{"key":"BF02244958_CR7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1476-5381.1983.tb09367.x","volume":"78","author":"P Cowen","year":"1983","unstructured":"Cowen P, Fraser S, Grahame-Smith D, Greer A, Stanford C (1983) The effect of chronic antidepressant administration on beta-adrenoceptor function of the beta-adrenoceptor of the rat pineal. Br J Pharmacol 78:89\u201396","journal-title":"Br J Pharmacol"},{"key":"BF02244958_CR8","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.725608","volume":"202","author":"C deMontigny","year":"1978","unstructured":"deMontigny C, Aghajanian GK (1978) Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin. Science 202:1303\u20131306","journal-title":"Science"},{"key":"BF02244958_CR9","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0024-3205(87)90636-9","volume":"41","author":"S Dilsaver","year":"1987","unstructured":"Dilsaver S, Davidson R (1987) Fluoxetine subsensitizes a nicotinic mechanism involved in the regulation of core temperature. Life Sci 41:1165\u20131169","journal-title":"Life Sci"},{"key":"BF02244958_CR10","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/0024-3205(83)90360-0","volume":"32","author":"A Dumbrille-Ross","year":"1983","unstructured":"Dumbrille-Ross A, Tang SW (1983) Manipulations of synaptic serotonin: discrepancy of effects on serotonin S1 and S2 sites. Life Sci 32:2677\u20132684","journal-title":"Life Sci"},{"key":"BF02244958_CR11","first-page":"126","volume":"21","author":"CJ Fowler","year":"1984","unstructured":"Fowler CJ, Magnusson O, Svante BR (1984) Intra- and extraneuronal monoamine oxidase. Blood Vessels 21:126\u2013131","journal-title":"Blood Vessels"},{"key":"BF02244958_CR12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0028-3908(83)90188-0","volume":"22","author":"K Fuxe","year":"1983","unstructured":"Fuxe K, Ogren S, Agnoti L, Benfenati F, Fredholm B, Andersson K, Zini I, Eneroth P (1983) Chronic antidepressant treatment and central 5-HT synapses. Neuropharmacology 22:389\u2013400","journal-title":"Neuropharmacology"},{"key":"BF02244958_CR13","first-page":"535","volume-title":"Psychopharmacology: the third generation of progress","author":"GR Heninger","year":"1987","unstructured":"Heninger GR, Charney DS (1987) Mechanism of action of antidepressant treatment: implications for the etiology and treatment of depressive disorders. In: Meltzer H (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 535\u2013544"},{"key":"BF02244958_CR14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0014-2999(87)90429-8","volume":"138","author":"P Hrdina","year":"1987","unstructured":"Hrdina P (1987) Regulation of high- and low-affinity [3H] imipramine recognition sites in rat brain by chronic treatment with antidepressants. Eur J Pharmacol 138:159\u2013168","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR15","first-page":"161","volume":"4","author":"E Hwang","year":"1980","unstructured":"Hwang E, VanWoert M (1980) Acute versus chronic effects of serotonin uptake blockers on potentiation of the serotonin syndrome. Commun Psychopharmacol 4:161\u2013176","journal-title":"Commun Psychopharmacol"},{"key":"BF02244958_CR16","first-page":"79","volume":"29","author":"E Hwang","year":"1980","unstructured":"Hwang E, Magnussen J, VanWoert M (1980) Effects of chronic fluoxetine administration on serotonin metabolism. Res Commun Chem Pathol Pharmacol 29:79\u201398","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"BF02244958_CR17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.2042-7158.1984.tb04892.x","volume":"36","author":"B Jonzon","year":"1984","unstructured":"Jonzon B, Fredholm B (1984) Adenosine mechanisms are not affected by antidepressant concentrations of desipramine. J Pharm Pharmacol 36:846\u2013848","journal-title":"J Pharm Pharmacol"},{"key":"BF02244958_CR18","first-page":"191","volume":"235","author":"KG Lloyd","year":"1985","unstructured":"Lloyd KG, Thuret F, Pilc A (1985) Upregulation of \u03b3-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock. J Pharmacol Exp Ther 235:191\u2013198","journal-title":"J Pharmacol Exp Ther"},{"key":"BF02244958_CR19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0014-2999(80)90152-1","volume":"61","author":"A Maggi","year":"1980","unstructured":"Maggi A, U'Prichard DC, Enna SJ (1980) Differential effects of antidepressant treatment on brain monoaminergic receptors. Eur J Pharmacol 61:91\u201398","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF01249603","volume":"52","author":"J Maj","year":"1981","unstructured":"Maj J, Mogilnicka E, Klimek V, Kordecka-Magiera A (1981) Chronic treatment with antidepressants: potentiation of clonidine-induced aggression in mice via noradrenergic mechanism. J Neural Transm 52:189\u2013197","journal-title":"J Neural Transm"},{"key":"BF02244958_CR21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/BF00555203","volume":"84","author":"S Mason","year":"1984","unstructured":"Mason S, Angel A (1984) Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anesthesia model. Psychopharmacology 84:304\u2013309","journal-title":"Psychopharmacology"},{"key":"BF02244958_CR22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0024-3205(80)90018-1","volume":"27","author":"D Menkes","year":"1980","unstructured":"Menkes D, Aghajanian G, McCall R (1980) Chronic antidepressant treatment enhances alpha-adrenergic and serotonergic responses in the facial nucleus. Life Sci 27:45\u201355","journal-title":"Life Sci"},{"key":"BF02244958_CR23","first-page":"365","volume":"2","author":"R Mishra","year":"1978","unstructured":"Mishra R, Sulser F (1978) Role of serotonin reuptake inhibition in the development of subsensitivity of the norepinephrine (NE) receptor coupled adenylate cyclase system. Commun Psychopharmacol 2:365\u2013369","journal-title":"Commun Psychopharmacol"},{"key":"BF02244958_CR24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(79)90246-2","volume":"60","author":"R Mishra","year":"1979","unstructured":"Mishra R, Janowsky A, Sulser F (1979) Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: effects of nisoxetine versus fluoxetine. Eur J Pharmacol 60:379\u2013382","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/BF00505652","volume":"316","author":"R Mishra","year":"1981","unstructured":"Mishra R, Leith N, Steranka L, Sulser F (1981) The noradrenalin receptor coupled adrenylate cyclase system in brain: lack of modification by changes in availability of serotonin. Arch Pharm 316:218\u2013224","journal-title":"Arch Pharm"},{"key":"BF02244958_CR26","first-page":"291","volume-title":"Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors","author":"L Oreland","year":"1984","unstructured":"Oreland L, Arai Y, Stenstr\u00f6m A (1984) Age, neuro-psychiatric diseases and brain monoamine oxidase. In: Tipton KF, Dostert P, Strolin Benedetti M (eds) Monoamine oxidase and disease. Prospects for therapy with reversible inhibitors. Academic Press, London, pp 291\u2013300"},{"key":"BF02244958_CR27","first-page":"303","volume-title":"Psychopharmacology: the third generation of progress","author":"S Peroutka","year":"1987","unstructured":"Peroutka S (1987) Serotonin receptors. In: Meltzer H (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 303\u2013312"},{"key":"BF02244958_CR28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.6251550","volume":"210","author":"SJ Peroutka","year":"1980","unstructured":"Peroutka SJ, Snyder SH (1980) Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science 210:88\u201390","journal-title":"Science"},{"key":"BF02244958_CR29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.2042-7158.1987.tb06971.x","volume":"39","author":"A Pilc","year":"1987","unstructured":"Pilc A (1987) The role of alpha2-adrenoceptors in the mechanism of action of antidepressant drugs. Pol J Pharmacol Pharm 39:691\u2013713","journal-title":"Pol J Pharmacol Pharm"},{"key":"BF02244958_CR30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-2999(86)90616-3","volume":"132","author":"A Pilc","year":"1986","unstructured":"Pilc A, Enna S (1986) Antidepressant administration has a differential effect on rat brain alpha2-adrenoceptor sensitivity to agonists and antagonists. Eur J Pharmacol 132:277\u2013282","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR31","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/0024-3205(77)90153-9","volume":"21","author":"JF Reinhard Jr","year":"1977","unstructured":"Reinhard JF Jr, Wurtman RJ (1977) Relation between brain 5-HIAA levels and the release of serotonin into brain synapses. Life Sci 21:1741\u20131746","journal-title":"Life Sci"},{"key":"BF02244958_CR32","first-page":"94","volume":"230","author":"E Richelson","year":"1984","unstructured":"Richelson E, Nelson A (1984) Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J Pharmacol Exp Ther 230:94\u2013102","journal-title":"J Pharmacol Exp Ther"},{"key":"BF02244958_CR33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-2999(84)90403-5","volume":"104","author":"E Richelson","year":"1984","unstructured":"Richelson E, Pfenning M (1984) Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. Eur J Pharmacol 104:277\u2013286","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1471-4159.1987.tb04136.x","volume":"48","author":"SB Ross","year":"1987","unstructured":"Ross SB (1987) Distribution of the two forms of monoamine oxidase within monoaminergic neurons of the guinea pig brain. J Neurochem 48:609\u2013614","journal-title":"J Neurochem"},{"key":"BF02244958_CR35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0014-2999(79)90344-3","volume":"58","author":"D Savage","year":"1979","unstructured":"Savage D, Frazer A, Mendels J (1979) Differential effects of monoamine oxidase inhibitors and serotonin reuptake inhibitors on3H-serotonin receptor binding in rat brain. Eur J Pharmacol 58:87\u201388","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR36","first-page":"259","volume":"212","author":"D Savage","year":"1980","unstructured":"Savage D, Mendels J, Frazer A (1980) Monoamine oxidase inhibitors and serotonin uptake inhibitors: differential effects on [3H]-serotonin binding sites in rat brain. J Pharmacol Exp Ther 212:259\u2013263","journal-title":"J Pharmacol Exp Ther"},{"key":"BF02244958_CR37","first-page":"42","volume":"229","author":"MJ Schmidt","year":"1977","unstructured":"Schmidt MJ, Thornberry JF (1977) Norepinephrine-stimulated cyclic AMP accumulation in brain slices in vitro after serotonin depletion or chronic administration of selective amine reuptake inhibitors. Arch Int Pharmacodyn 229:42\u201351","journal-title":"Arch Int Pharmacodyn"},{"key":"BF02244958_CR38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-2007-1019525","volume":"15","author":"SH Snyder","year":"1982","unstructured":"Snyder SH, Peroutka SJ (1982) A possible role of serotonin receptors in antidepressant drug action. Pharmacopsychiatry 15:131\u2013134","journal-title":"Pharmacopsychiatry"},{"key":"BF02244958_CR39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-2999(81)90531-8","volume":"74","author":"C Spyraki","year":"1981","unstructured":"Spyraki C, Fibiger H (1981) Behavioral evidence for supersensitivity of postsynaptic dopamine receptors in the mesolimbic system after chronic administration of desipramine. Eur J Pharmacol 74:195\u2013206","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR40","first-page":"53","volume":"46","author":"P Stark","year":"1985","unstructured":"Stark P, Hardison CD (1985) A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder. J Clin Psychiatry 46:53\u201358","journal-title":"J Clin Psychiatry"},{"key":"BF02244958_CR41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00427959","volume":"80","author":"JF Stolz","year":"1983","unstructured":"Stolz JF, Marsden CA, Middlemiss DN (1983) Effect of chronic antidepressant treatment and subsequent withdrawal of [3H]-5-hydroxytryptamine and [3H]-spiperone binding in rat frontal cortex and serotonin receptor mediated behaviour. Psychopharmacology 80:150\u2013155","journal-title":"Psychopharmacology"},{"key":"BF02244958_CR42","first-page":"131","volume":"4","author":"MF Sugrue","year":"1980","unstructured":"Sugrue MF (1980) The inability of chronic fluoxetine to potentiate a serotonin mediated effect. Commun Psychopharmacol 4:131\u2013134","journal-title":"Commun Psychopharmacol"},{"key":"BF02244958_CR43","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/oxfordjournals.bmb.a070979","volume":"29","author":"KF Tipton","year":"1973","unstructured":"Tipton KF (1973) Biochemical aspects of monoamine oxidase. Br Med Bull 29:116\u2013119","journal-title":"Br Med Bull"},{"key":"BF02244958_CR44","first-page":"19","volume":"48","author":"JK Wamsley","year":"1987","unstructured":"Wamsley JK, Byerley WF, McCabe RT, et al. (1987) Receptor alterations associated with serotonergic agents: an autoradiographic analysis. J Clin Psychiatry 48:19\u201325","journal-title":"J Clin Psychiatry"},{"key":"BF02244958_CR45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0014-2999(86)90596-0","volume":"132","author":"T Wander","year":"1986","unstructured":"Wander T, Nelson A, Okazaki H, et al. (1986) Antagonism by antidepressants of serotonin S1 and S2 receptors of normal human brain in vitro. Eur J Pharmacol 132:115\u2013121","journal-title":"Eur J Pharmacol"},{"key":"BF02244958_CR46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/syn.890040410","volume":"4","author":"SA Welner","year":"1989","unstructured":"Welner SA, deMontigny C, Desroches J, Desjardins P, Suranyi-Cadotte BE (1989) Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse 4:347\u2013352","journal-title":"Synapse"},{"key":"BF02244958_CR47","first-page":"164","volume":"23","author":"JF Wernicke","year":"1987","unstructured":"Wernicke JF, Dunlop SR, Dornseif BE, Zerbe RL (1987) Fixed-dose fluoxetine therapy for depression. Psychopharmacol Bull 23:164\u2013168","journal-title":"Psychopharmacol Bull"},{"key":"BF02244958_CR48","first-page":"183","volume":"24","author":"JF Wernicke","year":"1988","unstructured":"Wernicke JF, Dunlop SR, Dornseif BE et al. (1988) Low-dose fluoxetine therapy for depression. Psychopharmacol Bull 24:183\u2013188","journal-title":"Psychopharmacol Bull"},{"key":"BF02244958_CR49","first-page":"41","volume":"32","author":"DT Wong","year":"1981","unstructured":"Wong DT, Bymaster FP (1981) Subsensitivity of serotonin receptors after long-term treatment of rats with fluoxetine. Res Commun Chem Pathol Pharmacol 32:41\u201351","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"BF02244958_CR50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF01256471","volume":"64","author":"DT Wong","year":"1985","unstructured":"Wong DT, Reid LR, Bymaster FP, Threlkeld PG (1985) Chronic effects of fluoxetine, a selective inhibitor of serotonin uptake, on neurotransmitter receptors. J Neural Transm 64:251\u2013269","journal-title":"J Neural Transm"},{"key":"BF02244958_CR51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ddr.430100106","volume":"10","author":"TT Yen","year":"1987","unstructured":"Yen TT, Wong DT, Bemis KG (1987) Reduction of food consumption and body weight of normal and obese mice by chronic treatment with fluoxetine: a serotonin reuptake inhibitor. Drug Dev Res 10:37\u201345","journal-title":"Drug Dev Res"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02244958.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02244958\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02244958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T13:33:11Z","timestamp":1557927191000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02244958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["BF02244958"],"URL":"https:\/\/doi.org\/10.1007\/bf02244958","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}