{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T18:58:22Z","timestamp":1773601102115,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["In Vitro Cell Dev Biol - Animal"],"published-print":{"date-parts":[[1992,6]]},"DOI":"10.1007\/bf02634049","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T18:36:33Z","timestamp":1179599793000},"page":"445-448","source":"Crossref","is-referenced-by-count":20,"title":["Transforming growth factor-beta: Its effect on phenotype reexpression by dedifferentiated chondrocytes in the presence and absence of osteogenin"],"prefix":"10.1007","volume":"28","author":[{"suffix":"Jr.","given":"Edward T.","family":"Harrison","sequence":"first","affiliation":[]},{"given":"Frank P.","family":"Luyten","sequence":"additional","affiliation":[]},{"given":"A. H.","family":"Reddi","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF02634049_CR1","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1016\/S0021-9258(18)69173-2","volume":"263","author":"A. Bassols","year":"1988","unstructured":"Bassols, A.; Massague, J. Transforming growth factor-beta regulates the expression and structure of extracellular matrix chondroitin\/dermatan sulfate proteoglycan. J. Biol. Chem. 263:3039\u20133045; 1988.","journal-title":"J. Biol. Chem."},{"key":"BF02634049_CR2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/20.4.279","volume":"20","author":"D. Baylink","year":"1972","unstructured":"Baylink, D.; Wergedal, J.; Thompson, E. Loss of proteinpolysaccharides at sites where bone mineralization is initiated. J. Histochem. Cytochem. 20:279\u2013292; 1972.","journal-title":"J. Histochem. Cytochem."},{"key":"BF02634049_CR3","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1073\/pnas.84.15.5287","volume":"84","author":"J. Chen","year":"1987","unstructured":"Chen, J.; Hoshi, H.; McKeehan, W. L. Transforming growth factor type beta specifically stimulates synthesis of proteoglycan in human adult arterial smooth muscle cells. Proc. Natl. Acad. Sci. USA 84:5287\u20135291; 1987.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02634049_CR4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1749-6632.1990.tb16138.x","volume":"593","author":"D. A. Frenz","year":"1990","unstructured":"Frenz, D. A.; Van De Water, T. R. TGF-beta 1 modulation of chondrogenic differentiation by cultured periotic mesenchymal cells. In: Piez, K. A.; Sporn, M. B., eds. Transforming growth factors-beta; chemistry, biology, and therapeutics. Ann. NY Acad. Sci. 593:340\u2013342; 1990.","journal-title":"Ann. NY Acad. Sci."},{"key":"BF02634049_CR5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0014-4827(91)90050-5","volume":"192","author":"E. T. Harrison Jr.","year":"1991","unstructured":"Harrison, E. T., Jr.; Luyten, F. P.; Reddi, A. H. Osteogenin promotes re-expression of cartilage phenotype by dedifferentiated articular chondrocytes in serum-free medium. Exp. Cell Res. 192:340\u2013345; 1991.","journal-title":"Exp. Cell Res."},{"key":"BF02634049_CR6","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0021-9258(17)35666-1","volume":"261","author":"R. A. Ignotz","year":"1986","unstructured":"Ignotz, R. A.; Massague, J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen in their incorporation into the extracellular matrix. J. Biol. Chem. 261:4337\u20134345; 1986.","journal-title":"J. Biol. Chem."},{"key":"BF02634049_CR7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jcp.1041380216","volume":"138","author":"H. Inoue","year":"1989","unstructured":"Inoue, H.; Kato, Y.; Iwamato, M., et al. Stimulation of cartilage-matrix proteoglycan synthesis by morphologically transformed chondrocytes grown in the presence of fibroblast growth factor and transforming growth factor-beta. J. Cell. Physiol. 138:329\u2013337; 1989.","journal-title":"J. Cell. Physiol."},{"key":"BF02634049_CR8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/0006-291X(89)92208-0","volume":"159","author":"M. Iwamoto","year":"1989","unstructured":"Iwamoto, M.; Sato, K.; Nakashima, K., et al. Regulation of colony formation of differentiated chondrocytes in soft agar by transforming growth factor-beta. Biochem. Biophys. Res. Commun. 159:1006\u20131011; 1989.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BF02634049_CR9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0012-1606(89)90191-7","volume":"135","author":"W. M. Kulyk","year":"1989","unstructured":"Kulyk, W. M.; Rodgers, B. J.; Greer, K., et al. Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-beta. Dev. Biol. 135:424\u2013430; 1989.","journal-title":"Dev. Biol."},{"key":"BF02634049_CR10","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"237","author":"U. K. Laemmli","year":"1970","unstructured":"Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 237:680\u2013685; 1970.","journal-title":"Nature"},{"key":"BF02634049_CR11","doi-asserted-by":"crossref","first-page":"13377","DOI":"10.1016\/S0021-9258(18)80003-5","volume":"264","author":"F. Luyten","year":"1989","unstructured":"Luyten, F.; Cunningham, N. S.; Ma, S., et al. Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J. Biol. Chem. 264:13377\u201313380; 1989.","journal-title":"J. Biol. Chem."},{"key":"BF02634049_CR12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1432-1033.1990.tb15327.x","volume":"187","author":"R. M. Lyons","year":"1990","unstructured":"Lyons, R. M.; Moses, H. L. Transforming growth factors and the regulation of cell proliferation. Eur. J. Biochem. 187:467\u2013473; 1990.","journal-title":"Eur. J. Biochem."},{"key":"BF02634049_CR13","doi-asserted-by":"crossref","first-page":"12828","DOI":"10.1016\/S0021-9258(18)37634-8","volume":"263","author":"T. I. Morales","year":"1988","unstructured":"Morales, T. I.; Roberts, A. B. Transforming growth factor-beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures. J. Biol. Chem. 263:12828\u201312831; 1988.","journal-title":"J. Biol. Chem."},{"key":"BF02634049_CR14","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1073\/pnas.69.6.1601","volume":"69","author":"A. H. Reddi","year":"1972","unstructured":"Reddi, A. H.; Huggins, C. Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. Proc. Natl. Acad. Sci. USA 69:1601\u20131605; 1972.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02634049_CR15","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1021\/bi00610a003","volume":"17","author":"R. K. Rhodes","year":"1978","unstructured":"Rhodes, R. K.; Miller, E. J. Physicochemical characterization and molecular organization of collagen A and B chains. Biochemistry 17:3442\u20133448; 1978.","journal-title":"Biochemistry"},{"key":"BF02634049_CR16","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1073\/pnas.83.12.4167","volume":"83","author":"A. B. Roberts","year":"1986","unstructured":"Roberts, A. B.; Sporn, M. B.; Assoian, R. K., et al. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA 83:4167\u20134171; 1986.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02634049_CR17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0021-9258(19)78194-0","volume":"244","author":"S. W. Sajdera","year":"1969","unstructured":"Sajdera, S. W.; Hascall, V. C. Proteinpolysaccharide complex from bovine nasal cartilage. J. Biol. Chem. 244:77\u201387; 1969.","journal-title":"J. Biol. Chem."},{"key":"BF02634049_CR18","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1073\/pnas.84.20.7109","volume":"84","author":"T. K. Sampath","year":"1987","unstructured":"Sampath, T. K.; Muthukumaran, N.; Reddi, A. H. Isolation of osteogenin, an extracellular matrix-associated, bone-inductive protein, by heparin affinity chromatography. Proc. Natl. Acad. Sci. USA 84:7109\u20137113; 1987.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02634049_CR19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00306130","volume":"5","author":"J. E. Scott","year":"1965","unstructured":"Scott, J. E.; Dorling, J. Staining of acid glycosaminoglycans (mucopolysaccharides) by Alcian Blue in salt solutions. Histochemie 5:221\u2013233; 1965.","journal-title":"Histochemie"},{"key":"BF02634049_CR20","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1073\/pnas.82.8.2267","volume":"82","author":"S. M. Seyedin","year":"1985","unstructured":"Seyedin, S. M.; Thomas, T. C.; Thompson, A. Y., et al. Purification and characterization of two cartilage-inducing factors from bovine demineralized bone. Proc. Natl. Acad. Sci. USA 82:2267\u20132271; 1985.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02634049_CR21","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","volume":"150","author":"M. R. Urist","year":"1965","unstructured":"Urist, M. R. Bone: formation by autoinduction. Science 150:893\u2013899; 1965.","journal-title":"Science"},{"key":"BF02634049_CR22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj2470597","volume":"247","author":"J. Varga","year":"1987","unstructured":"Varga, J.; Rosenbloom, J.; Jimenez, S. Transforming growth factor (TGF-beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human derived fibroblasts. Biochem. J. 247:597\u2013604; 1987.","journal-title":"Biochem. J."},{"key":"BF02634049_CR23","doi-asserted-by":"crossref","first-page":"8793","DOI":"10.1073\/pnas.86.22.8793","volume":"86","author":"S. Vukicevic","year":"1989","unstructured":"Vukicevic, S.; Luyten, F. P.; Reddi, A. H. Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc. Natl. Acad. Sci. USA 86:8793\u20138797; 1989.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BF02634049_CR24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/bj1310343","volume":"131","author":"P. Whiteman","year":"1973","unstructured":"Whiteman, P. The quantitative measurement of alcian blue-glycosaminoglycan complexes. Biochem. J. 131:343\u2013350; 1973.","journal-title":"Biochem. J."}],"container-title":["In Vitro Cellular &amp; Developmental Biology - Animal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02634049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02634049\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02634049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T23:34:59Z","timestamp":1628897699000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02634049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["BF02634049"],"URL":"https:\/\/doi.org\/10.1007\/bf02634049","relation":{},"ISSN":["0883-8364","1543-706X"],"issn-type":[{"value":"0883-8364","type":"print"},{"value":"1543-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}