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Agents are one of the most promising technologies for the development of Semantic Web software products. However, agent-based technologies will not become widespread until there are adequate infrastructures for the development of semantic multi-agent systems (MAS). Some challenges, such as turning software agents into practical abstractions for dealing with ontologies, taking advantage of the distributed nature of the Web to create distributed agents and making a seamless integration with existing Web tools, e.g. the browser, still need to be addressed. This paper describes the main features of the SemantiCore framework, an agent infrastructure to develop semantic MAS. 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