{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:00:21Z","timestamp":1768798821726,"version":"3.49.0"},"publisher-location":"Berlin, Heidelberg","reference-count":23,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540648918","type":"print"},{"value":"9783540685159","type":"electronic"}],"license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998]]},"DOI":"10.1007\/bfb0040797","type":"book-chapter","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T13:05:14Z","timestamp":1139231114000},"page":"449-461","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Fully automated and rapid flexible docking of inhibitors covalently bound to serine proteases"],"prefix":"10.1007","author":[{"given":"Daniel K.","family":"Gehlhaar","sequence":"first","affiliation":[]},{"given":"Djamal","family":"Bouzida","sequence":"additional","affiliation":[]},{"given":"Paul A.","family":"Rejto","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2005,12,10]]},"reference":[{"key":"44_CR1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/ar00041a001","volume":"27","author":"I. D. Kuntz","year":"1994","unstructured":"Kuntz, I. D.; Meng, E. C.; Shoichet, B. K. Accts. Chem. Res. 1994, 27, 117\u2013123.","journal-title":"Accts. Chem. Res."},{"key":"44_CR2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"G. Jones","year":"1997","unstructured":"Jones, G.; Willett, P., Glen, R. C.; Leach, A. R.; Taylor, R. J. Mol. Biol. 1997, 267, 727\u2013748.","journal-title":"J. Mol. Biol."},{"key":"44_CR3","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/(SICI)1096-987X(19971115)18:14<1812::AID-JCC10>3.0.CO;2-H","volume":"18","author":"I. D. Kuntz","year":"1997","unstructured":"Kuntz, I. D.; Makino, S. J. Comp. Chem, 1997, 18, 1812\u20131825.","journal-title":"J. Comp. Chem"},{"key":"44_CR4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1096\/fasebj.11.2.9039959","volume":"11","author":"J. Desmet","year":"1997","unstructured":"Desmet, J.; Wilson, I. A.; Joniau, M.; DeMaeyer, M.; Lasters, I. FASEB J. 1997, 11, 164\u2013172.","journal-title":"FASEB J."},{"key":"44_CR5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1074-5521(96)90093-9","volume":"3","author":"W. Welch","year":"1996","unstructured":"Welch, W.; Ruppert, J.; Jain, A. N. Chem. Biol. 1996, 3, 449\u2013463.","journal-title":"Chem. Biol."},{"key":"44_CR6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1006\/jmbi.1996.0477","volume":"261","author":"M. Rarey","year":"1996","unstructured":"Rarey, M.; Kramer, B.; Lengauer, T.; Klebe, G. J. Mol. Biol. 1996, 261, 470\u2013489.","journal-title":"J. Mol. Biol."},{"key":"44_CR7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/1074-5521(95)90050-0","volume":"2","author":"D. K. Gehlhaar","year":"1995","unstructured":"Gehlhaar, D. K.; Verkhivker, G. M.; Rejto, P. A.; Sherman, C. J.; Fogel, D. B.; Fogel, L. J.; Freer, S. T. Chem. Biol. 1995, 2, 317\u2013324.","journal-title":"Chem. Biol."},{"key":"44_CR8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0092-8674(00)80157-9","volume":"86","author":"P. Chen","year":"1996","unstructured":"Chen, P.; Tsuge, H.; Almassy, R. J.; Gribskov, C. L.; Katoh, S.; Vanderpool, D. L.; Margosiak, S. A.; Pinko, C; Matthews, D. A.; Kan, C.-C. Cell 1996, 86, 835\u2013843.","journal-title":"Cell"},{"key":"44_CR9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)81350-1","volume":"86","author":"R. A. Love","year":"1996","unstructured":"Love, R. A.; Parge, H. E.; Wickersham, J. A.; Hostomsky, Z.; Habuka, N.; Moomaw, E. W.; Adachi, T.; Hostomska, Z. Cell 1996, 86, 331\u2013342.","journal-title":"Cell"},{"key":"44_CR10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0092-8674(00)81351-3","volume":"87","author":"J. L. Kim","year":"1996","unstructured":"Kim, J. L. Morgenstern, K. A.; Lin, C.; Fox, T.; Dwyer, M. D.; Landro, J. A.; Chambers, S. P.; Markland, W.; Lepre, C. A.; O'Malley, E. T.; Harbeson, S. L.; Rice, C. M.; Murcko, M. A.; Caron, P. R.; Thomson, J. A. Cell 1996, 87, 343\u2013355.","journal-title":"Cell"},{"key":"44_CR11","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/cr960370z","volume":"97","author":"R. E. Babine","year":"1997","unstructured":"Babine, R. E.; Bender, S. L. Chem. Rev. 1997, 97, 1359\u20131472.","journal-title":"Chem. Rev."},{"key":"44_CR12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1146\/annurev.bi.62.070193.002551","volume":"62","author":"A. Wlodawer","year":"1993","unstructured":"Wlodawer, A.; Erickson, J. W. Annu. Rev. Biochem. 1993, 62, 543\u2013585.","journal-title":"Annu. Rev. Biochem."},{"key":"44_CR13","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1021\/jm00111a001","volume":"34","author":"K. Appelt","year":"1991","unstructured":"Appelt, K.; Bacquet, R. J.; Bartlett, C. A.; Booth, C. L.; Freer, S. T.; Fuhry, M. A. M.; Gehring, M. R.; Herrmann, S. M.; Howland, E. F.; Janson, C. A.; Jones, T. R.; Kan, C.; Kathardekar, V.; Lewis, K. K.; Marzoni, G. P.; Matthews, D. A.; Mohr, C.; Moomaw, E. W.; Morse, C. A.; Oatley, S. J.; Ogden, R. C.; Reddy, M. R.; Reich, S. H.; Schoettlin, W. S.; Smith, W. W.; Varney, M. D.; Villafranca, J. E.; Ward, R. W.; Webber, S.; Webber, S. E.; Welsh, K. M.; White, J. J. Med. Chem. 1991, 34, 1925\u20131934.","journal-title":"J. Med. Chem."},{"key":"44_CR14","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1128\/JVI.70.7.4819-4824.1996","volume":"70","author":"R. L. LaFemina","year":"1996","unstructured":"LaFemina, R. L.; Bakshi, K.; Long, W. J.; Pramanik, B.; Veloski, C. A.; Wolanski, B. S.; Marcy, A.; Hazuda, D. J. J. Virology 1996, 70, 4819\u20134824.","journal-title":"J. Virology"},{"key":"44_CR15","doi-asserted-by":"crossref","first-page":"8897","DOI":"10.1021\/j100389a010","volume":"94","author":"S. L. Mayo","year":"1990","unstructured":"Mayo, S. L.; Olafson, B. D.; Goddard, W. A. J. Phys. Chem. 1990, 94, 8897\u20138909.","journal-title":"J. Phys. Chem."},{"key":"44_CR16","first-page":"75","volume-title":"Evolutionary Computation: Towards a New Philosophy of Machine Intelligence","author":"D.B. Fogel","year":"1995","unstructured":"Fogel, D.B. Evolutionary Computation: Towards a New Philosophy of Machine Intelligence. IEEE Press: New York, NY, 1995; 75\u2013155."},{"key":"44_CR17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1107\/S010876739101067X","volume":"A47","author":"S. R. Hall","year":"1991","unstructured":"Hall, S. R.; Allen, F. H.; Brown, I. D. Acta Cryst. 1991, A47, 655\u2013685.","journal-title":"Acta Cryst."},{"key":"44_CR18","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jcc.540110405","volume":"11","author":"F. Mohamadi","year":"1990","unstructured":"Mohamadi, F.; Richards, N. G. J.; Guida, W. C.; Kiskamp, M.; Caufield, C; Chang, G.; Hendrickson, T.; Still, W. C. J. Comput. Chem. 1990, 11, 440\u2013467.","journal-title":"J. Comput. Chem."},{"key":"44_CR19","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/ja00315a051","volume":"106","author":"S. J. Weiner","year":"1984","unstructured":"Weiner, S. J.; Kollman, P. A.; Case, D. A.; Singh, U. C.; Ghio, C.; Algona, G.; Profeta, S. Jr.; Weiner, P. J. J. Am. Chem. Soc. 1984, 106, 765\u2013784.","journal-title":"J. Am. Chem. Soc."},{"key":"44_CR20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-2836(77)80200-3","volume":"112","author":"F. C. Bernstein","year":"1977","unstructured":"Bernstein, F. C.; Koetzle, T. F.; Williams, G. J.; Meyer, E. F. Jr.; Brice, M. D.; Rodgers, J. R.; Kennard, O.; Shimanouchi, T.; Tasumi, M. J. Mol. Biol. 1977, 112, 535\u2013542.","journal-title":"J. Mol. Biol."},{"key":"44_CR21","volume-title":"Computer-Assisted Molecular Design Course","author":"P. W. Rose","year":"1997","unstructured":"Rose, P. W. In Computer-Assisted Molecular Design Course, UCSF; San Francisco, CA, 1997; Chapter 12."},{"key":"44_CR22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00126743","volume":"8","author":"H. J. Bohm","year":"1994","unstructured":"Bohm, H. J. J. Comput. Aided Mol. Des. 1994, 8, 243\u2013256.","journal-title":"J. Comput. Aided Mol. Des."},{"key":"44_CR23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1006\/jmbi.1994.1334","volume":"238","author":"I. K. McDonald","year":"1994","unstructured":"McDonald, I. K.; Thornton, J. M. J. Mol. Biol. 1994, 238, 777\u2013793.","journal-title":"J. Mol. Biol."}],"container-title":["Lecture Notes in Computer Science","Evolutionary Programming VII"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BFb0040797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T13:22:06Z","timestamp":1586697726000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BFb0040797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"ISBN":["9783540648918","9783540685159"],"references-count":23,"URL":"https:\/\/doi.org\/10.1007\/bfb0040797","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998]]},"assertion":[{"value":"10 December 2005","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}