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A central ethical concern is the compatibility of these systems with the moral preferences of their users\u2014an issue especially relevant to participatory approaches within the ethics-by-design debate. However, users\u2019 incapacity to communicate preferences or to participate in design processes, e.g., due to dementia, presents a hurdle for participatory ethics-by-design approaches. In this paper, we explore the question of how the value preferences of users in the field of dementia care can be integrated into AI-based MATs. First, we briefly introduce different ethics-by-design approaches and explain the challenges they face in dementia care. Next, we introduce a novel approach for addressing these challenges. Through a qualitative content analysis of interviews with persons with dementia and their family caregivers (<jats:italic>n<\/jats:italic>\u00a0=\u00a027), we identified multiple ideal\u2013typical value preference profiles. We then applied these profiles in a computer simulation, by which we also introduce the concept of ethical compliance quantification to scale the moral preferences of the interviewees for the simulation. Finally, we discuss study results, the advantages of using computer simulations, and general study limitations before drawing conclusions for further research. The study contributes to the ongoing debate on participatory ethics-by-design by defining on the basis of empirical data ideal\u2013typical value preference frameworks that can be used to guide MAT actions and their outcomes. Going forward, MAT end-users with dementia and other communication-impaired persons could be enabled to choose a value profile that best fits their moral preferences.<\/jats:p>","DOI":"10.1007\/s00146-024-01947-7","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T12:52:08Z","timestamp":1714567928000},"page":"1209-1225","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Value preference profiles and ethical compliance quantification: a new approach for ethics by design in technology-assisted dementia care"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-0827","authenticated-orcid":false,"given":"Eike","family":"Buhr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-4335","authenticated-orcid":false,"given":"Johannes","family":"Welsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-4879","authenticated-orcid":false,"given":"M. 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