{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:47Z","timestamp":1762100447834},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,26]],"date-time":"2005-11-26T00:00:00Z","timestamp":1132963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The angiogenic factor called vascular endothelial growth factor (VEGF)\u2010D is a ligand for VEGF receptor\u20102 (VEGFR\u20102\/KDR) and receptor\u20103 (VEGFR\u20103\/Flt\u20104). It is implicated in the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to investigate the prognostic significance of VEGF\u2010D expression in patients with gastric carcinoma. We assessed the expression of VEGF\u2010D in gastric carcinoma by immunohistochemistry on 143 consecutive patients\u2019 stored sections and evaluated the lymphatic vessel count (LVC) in tumors using the novel selective lymphatic endothelium marker D2\u201040. VEGF\u2010D expression was observed in 55 (39%) tumor sections. The expression of VEGF\u2010D correlated significantly with tumor size, T of the TNM classification, lymphatic and venous system invasion, LVC, lymph node metastasis, M of TNM, and pTNM stage. Multivariate analysis indicated that VEGF\u2010D expression was an independent prognostic factor for both relapse\u2010free survival (RFS) and overall survival (OS). Our data indicate the involvement of VEGF\u2010D in tumor progression via lymphoangiogenic pathways. Practically, VEGF\u2010D expression can be useful for predicting RFS and OS in patients with gastric carcinoma.<\/jats:p>","DOI":"10.1007\/s00268-005-0076-z","type":"journal-article","created":{"date-parts":[[2005,11,26]],"date-time":"2005-11-26T08:38:23Z","timestamp":1132994303000},"page":"1600-1607","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic Significance of Vascular Endothelial Growth Factor D in Gastric Carcinoma"],"prefix":"10.1002","volume":"29","author":[{"given":"Atsuo","family":"Shida","sequence":"first","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine Nishi\u2010shinbashi, 3\u201025\u20108 105\u20108461 Minato\u2010ku Tokyo Japan"}]},{"given":"Shuichi","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Surgery Jikei University School of Medicine Nishi\u2010shinbashi, 3\u201025\u20108 105\u20108461 Minato\u2010ku Tokyo 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