{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:22:34Z","timestamp":1771957354674,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T00:00:00Z","timestamp":1269993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Chemother Pharmacol"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1007\/s00280-010-1310-4","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T11:34:27Z","timestamp":1269948867000},"page":"201-213","source":"Crossref","is-referenced-by-count":51,"title":["Streptomycin alleviates irinotecan-induced delayed-onset diarrhea in rats by a mechanism other than inhibition of \u03b2-glucuronidase activity in intestinal lumen"],"prefix":"10.1007","volume":"67","author":[{"given":"Akinobu","family":"Kurita","sequence":"first","affiliation":[]},{"given":"Shoichi","family":"Kado","sequence":"additional","affiliation":[]},{"given":"Tsuneo","family":"Matsumoto","sequence":"additional","affiliation":[]},{"given":"Naoyuki","family":"Asakawa","sequence":"additional","affiliation":[]},{"given":"Norimasa","family":"Kaneda","sequence":"additional","affiliation":[]},{"given":"Ikuo","family":"Kato","sequence":"additional","affiliation":[]},{"given":"Kazumi","family":"Uchida","sequence":"additional","affiliation":[]},{"given":"Masaharu","family":"Onoue","sequence":"additional","affiliation":[]},{"given":"Teruo","family":"Yokokura","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,3,31]]},"reference":[{"key":"1310_CR1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/jnci\/86.6.446","volume":"86","author":"D Abigerges","year":"1994","unstructured":"Abigerges D, Armand J-P, Chabot GG, da Costa L, Fadel E, Cote C, H\u00e9rait P, Gandia D (1994) Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. J Natl Cancer Inst 86:446\u2013449","journal-title":"J Natl Cancer Inst"},{"key":"1310_CR2","first-page":"6921","volume":"60","author":"Y Ando","year":"2000","unstructured":"Ando Y, Saka H, Ando M, Sawa T, Muro K, Ueoka H, Yokoyama A, Saitoh S, Shimokata K, Hasegawa Y (2000) Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. Cancer Res 60:6921\u20136926","journal-title":"Cancer Res"},{"key":"1310_CR3","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3109\/00498259109039556","volume":"21","author":"R Atsumi","year":"1991","unstructured":"Atsumi R, Suzuki W, Hakusui H (1991) Identification of metabolites of irinotecan, a new derivative of camptothecin, in the rat bile and its biliary excretion. Xenobiotica 21:1159\u20131169","journal-title":"Xenobiotica"},{"key":"1310_CR4","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1634\/theoncologist.11-8-944","volume":"11","author":"FA Jong De","year":"2006","unstructured":"De Jong FA, Kehrer DFS, Mathijssen RHJ, Creemers GJ, de Bruijn P, van Schaik RHN, Planting AST, van der Gaast A, Eskens FAL, Janssen JTP, Ruit JB, Verweij J, Sparreboom A, de Jonge MJA (2006) Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study. Oncologist 11:944\u2013954","journal-title":"Oncologist"},{"key":"1310_CR5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1200\/JCO.1992.10.1.16","volume":"10","author":"M Fukuoka","year":"1992","unstructured":"Fukuoka M, Niitani H, Suzuki A, Motomiya M, Hasegawa K, Nishiwaki Y, Kuriyama T, Ariyoshi Y, Negoro S, Masuda N, Nakajima S, Taguchi T (1992) A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer (see comment citation in Medline). J Clin Oncol 10:16\u201320","journal-title":"J Clin Oncol"},{"key":"1310_CR6","first-page":"2757","volume":"15","author":"T Furuta","year":"1998","unstructured":"Furuta T, Yokokura T, Mutai M (1998) Antitumor activity of CPT-11 against rat Walker 256 carcinoma (in Japanese). Jpn J Cancer Chemother 15:2757\u20132760","journal-title":"Jpn J Cancer Chemother"},{"key":"1310_CR7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1200\/JCO.1993.11.1.196","volume":"11","author":"D Gandia","year":"1993","unstructured":"Gandia D, Abigerges D, Armand J-P, Chabot GG, da Costa L, de Forni M (1993) CPT-11-induced cholinergic effects in cancer patients. J Clin Oncol 11:196\u2013197","journal-title":"J Clin Oncol"},{"key":"1310_CR8","first-page":"3723","volume":"54","author":"E Gupta","year":"1994","unstructured":"Gupta E, Lestingi TM, Mick R, Ramirez J, Vokes EE, Ratain MJ (1994) Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res 54:3723\u20133725","journal-title":"Cancer Res"},{"key":"1310_CR9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s002800050595","volume":"39","author":"E Gupta","year":"1997","unstructured":"Gupta E, Wang X, Ramirez J, Ratain MJ (1997) Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital. Cancer Chemother Pharmacol 39:40\u2013444","journal-title":"Cancer Chemother Pharmacol"},{"key":"1310_CR10","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1200\/JCO.2004.07.173","volume":"22","author":"F Innocenti","year":"2004","unstructured":"Innocenti F, Undevia SD, Iyer L, Chen PX, Das S, Kocherginsky M, Karrison T, Janisch L, Ram\u00edrez J, Rudin CM, Vokes EE, Ratain MJ (2004) Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22:1382\u20131388","journal-title":"J Clin Oncol"},{"key":"1310_CR11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1172\/JCI915","volume":"101","author":"L Iyer","year":"1998","unstructured":"Iyer L, King CD, Whitington PF, Green MD, Roy SK, Tephly TR, Coffman BL, Ratain MJ (1998) Genitic Predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest 101:847\u2013854","journal-title":"J Clin Invest"},{"key":"1310_CR12","first-page":"1721","volume":"50","author":"N Kaneda","year":"1990","unstructured":"Kaneda N, Yokokura T (1990) Nonlinear pharmacokinetics of CPT-11 in rats. Cancer Res 50:1721\u20131725","journal-title":"Cancer Res"},{"key":"1310_CR13","first-page":"7407","volume":"24","author":"Y Kawato","year":"1990","unstructured":"Kawato Y, Tsumori T, Akahane K, Sekiguchi M, Sato K (1990) Inhibitory effect of CPT-11, a derivative of camptothecin, on acetylcholinesterase, and its binding ability to acetylcholine receptors (in Japanese). Clin Rep 24:7407\u20137412","journal-title":"Clin Rep"},{"key":"1310_CR14","first-page":"4187","volume":"51","author":"Y Kawato","year":"1991","unstructured":"Kawato Y, Aonuma M, Hirota Y, Kuga H, Sato K (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51:4187\u20134191","journal-title":"Cancer Res"},{"key":"1310_CR15","first-page":"1136","volume":"7","author":"DFS Kehrer","year":"2001","unstructured":"Kehrer DFS, Sparreboom A, Verweij J, de Bruijn P, Nierop CA, van de Schraaf J, Ruijgrok EJ, de Jonge MJA (2001) Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients. Clin Cancer Res 7:1136\u20131141","journal-title":"Clin Cancer Res"},{"key":"1310_CR16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/(SICI)1097-0215(19991112)83:4<491::AID-IJC10>3.0.CO;2-M","volume":"83","author":"K Kobayashi","year":"1999","unstructured":"Kobayashi K, Bouscarel B, Matsuzaki Y, Ceryak S, Kudoh S, Fromm H (1999) pH-dependent uptake of irinotecan and its active metabolite, SN-38, by intestinal cells. Int J Cancer 83:491\u2013496","journal-title":"Int J Cancer"},{"key":"1310_CR17","first-page":"116","volume":"23","author":"A Kojima","year":"1993","unstructured":"Kojima A, Shinkai T, Saijo N (1993) Cytogenetic effects of CPT-11 and its active metabolite, SN-38 on human lymphocytes. Jpn J Clin Oncol 23:116\u2013122","journal-title":"Jpn J Clin Oncol"},{"key":"1310_CR18","first-page":"5944","volume":"47","author":"T Kunimoto","year":"1987","unstructured":"Kunimoto T, Nitta K, Tanaka T, Uehara M, Baba H, Takeuchi M, Yokokura T, Sawada S, Miyasaka T, Mutai M (1987) Antitumor activity of 7-ethyl-10-(4-(1-piperidino)-1-piperidino) carbonyloxycamptothecin, a novel water-soluble derivative of camptothecin, against murine tumors. Cancer Res 47:5944\u20135947","journal-title":"Cancer Res"},{"key":"1310_CR19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0378-4347(98)00554-4","volume":"724","author":"A Kurita","year":"1999","unstructured":"Kurita A, Kaneda N (1999) High-performance liquid chromatographic method for the simultaneous determination of the camptothecin derivative irinotecan hydrochloride, CPT-11, and its metabolites SN-38 and SN-38 glucuronide in rat plasma with a fully automated on-line solid phase extraction system, PROSPEKT. J Chromatogr B 724:335\u2013344","journal-title":"J Chromatogr B"},{"key":"1310_CR20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1124\/dmd.30.7.763","volume":"30","author":"FR Luo","year":"2002","unstructured":"Luo FR, Paranjpe PV, Guo A, Rubin E, Sinko P (2002) Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos 30:763\u2013770","journal-title":"Drug Metab Dispos"},{"key":"1310_CR21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0360-3016(02)03863-4","volume":"55","author":"VK Mehta","year":"2003","unstructured":"Mehta VK, Cho C, Ford JM, Jambalos C, Poen J, Koong A, Lin A, Bastidas JA, Young H, Dunphy EP, Fisher G (2003) Phase II trial of preoperative 3D conformal radiotherapy, protracted venous infusion 5-fluorouracil, and weekly CPT-11, followed by surgery for ultrasound-staged T3 rectal cancer. Int J Radiat Oncol Biol Phys 55:132\u2013137","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1310_CR22","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/jnci\/84.12.972","volume":"84","author":"Y Ohe","year":"1993","unstructured":"Ohe Y, Sakai Y, Shinkai T, Eguchi K, Tamura T, Kojima A, Kunikane H, Okamoto H, Karato A, Ohmatsu H, Kanzawa F, Saijo N (1993) Phase I study and pharmacokinetics of CPT-11 with 5-day continuous infusion. J Natl Cancer Inst 84:972\u2013974","journal-title":"J Natl Cancer Inst"},{"key":"1310_CR23","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1200\/JCO.1990.8.11.1907","volume":"8","author":"R Ohno","year":"1990","unstructured":"Ohno R, Okada K, Masaoka T, Kuramoto A, Arima T, Yoshida Y, Ariyoshi H, Ichimaru M, Sakai Y, Oguro M, Ito Y, Morishima Y, Yokomaru S, Ohta K (1990) An early II phase study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma. J Clin Oncol 8:1907\u20131912","journal-title":"J Clin Oncol"},{"key":"1310_CR24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00280-007-0512-x","volume":"61","author":"M Onoue","year":"2008","unstructured":"Onoue M, Kurita A, Kado S, Matsumoto T, Kaneda N, Uchida K, Kato I, Yokokura T (2008) Involvement of UDP-glucuronosyltransferase activity in Irinotecan-induced delayed-onset diarrhea in rats. Cancer Chemother Pharmacol 61:595\u2013605","journal-title":"Cancer Chemother Pharmacol"},{"key":"1310_CR25","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1200\/JCO.1993.11.11.2194","volume":"11","author":"ML Rothenberg","year":"1992","unstructured":"Rothenberg ML, Kuhn JG, Burris HA III, Morales MT, Nelson J, Eckardt JR, Rock MK, Terada K, von Hoff DD (1992) Phase I and pharmacokinetic trial of CPT-11 in patients with refractory solid tumors. Proc Am Soc Clin Oncol 11:2194\u20132204","journal-title":"Proc Am Soc Clin Oncol"},{"key":"1310_CR26","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1200\/JCO.1998.16.8.2745","volume":"16","author":"F Saliba","year":"1998","unstructured":"Saliba F, Hagipantelli R, Misset J-L, Bastian G, Vassal G, Bonnay M, Herait P, Cote C, Mahjoubi M, Mignard D, Cvitkovic E (1998) Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. J Clin Oncol 16:2745\u20132751","journal-title":"J Clin Oncol"},{"key":"1310_CR27","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/annonc\/mdh310","volume":"15","author":"A Schmittel","year":"2004","unstructured":"Schmittel A, Jahnke K, Thiel E, Keiholz U (2004) Neomycin as secondary prophylaxis for irinotecan-induced diarrhea. Ann Oncol 15:1296","journal-title":"Ann Oncol"},{"key":"1310_CR28","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1124\/dmd.106.010397","volume":"34","author":"MK Shelby","year":"2006","unstructured":"Shelby MK, Klassen CD (2006) Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways. Drug Metab Dispos 34:1772\u20131778","journal-title":"Drug Metab Dispos"},{"key":"1310_CR29","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1200\/JCO.1993.11.5.909","volume":"11","author":"Y Shimada","year":"1993","unstructured":"Shimada Y, Yoshino M, Wakui A, Nakao I, Futatsuki K, Sakata Y, Kambe M, Taguchi T, Ogawa N (1993) Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group. J Clin Oncol 11:909\u2013913","journal-title":"J Clin Oncol"},{"key":"1310_CR30","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1200\/JCO.1997.15.3.921","volume":"15","author":"K Shirao","year":"1997","unstructured":"Shirao K, Shimada Y, Kondo H, Saito D, Yamao T, Ono H, Yokoyama T, Fukuda H, Oka M, Watanabe Y, Ohtsu A, Boku N, Fujii T, Oda Y, Muro K, Yoshida S (1997) Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancer. J Clin Oncol 15:921\u2013927","journal-title":"J Clin Oncol"},{"key":"1310_CR31","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1349-7006.1995.tb03010.x","volume":"86","author":"K Takasuna","year":"1995","unstructured":"Takasuna K, Kasai Y, Kitano Y, Mori K, Kobayashi R, Hagiwara T, Kakihata K, Hirohashi M, Nomura M, Nagai E, Kamataki T (1995) Protective effects of Kampo medicine and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats. Jpn J Cancer Res 86:978\u2013984","journal-title":"Jpn J Cancer Res"},{"key":"1310_CR32","first-page":"3752","volume":"56","author":"K Takasuna","year":"1996","unstructured":"Takasuna K, Hasegawa T, Hirohashi M, Kato M, Nomura M, Nagai E, Yokoi T, Kamataki T (1996) Involvement of \u03b2-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride. Cancer Res 56:3752\u20133757","journal-title":"Cancer Res"},{"key":"1310_CR33","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s002800050818","volume":"42","author":"K Takasuna","year":"1998","unstructured":"Takasuna K, Hagiwara T, Hirohashi M, Kato M, Nomura M, Nagai E, Yokoi T, Kamataki T (1998) Inhibition of intestinal microflora \u03b2-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11), in rats. Cancer Chemother Pharmacol 42:280\u2013286","journal-title":"Cancer Chemother Pharmacol"},{"key":"1310_CR34","first-page":"1681","volume":"18","author":"S Takeuchi","year":"1991","unstructured":"Takeuchi S, Dobashi K, Fujimoto S, Tanaka K, Suzuki M, Terashima Y, Hasumi K, Akiya K, Negishi Y, Tamiya T, Tanizawa O, Sugawa T, Umesaki N, Sekiba K, Aono T, Nakano H, Noda K, Shirota M, Yakushiji M, Sugiyama T, Hashimoto M, Yajima A, Takamizawa H, Sonoda T, Takeda Y, Tomoda Y, Ohta M, Ozaki M, Hirabayashi K, Hiura M, Hatae M, Nishigaki K, Taguchi T (1991) A late phase II study of CPT-11 on uterine cervical cancer and ovarian cancer. Research groups of CPT-11 in Gynecologic Cancers (in Japanese). Jpn J Cancer Chemother 18:1681\u20131689","journal-title":"Jpn J Cancer Chemother"},{"key":"1310_CR35","first-page":"223","volume":"24","author":"PAM Leeuwen Van","year":"1986","unstructured":"Van Leeuwen PAM, Drukker J, van der Kleyn NM, van den Boogaard AEJM, Soeters PB (1986) Morphological effects of high dose neomycin sulphate on the small and large intestine. Acta Morphol Neerl-Scand 24:223\u2013234","journal-title":"Acta Morphol Neerl-Scand"},{"key":"1310_CR36","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/carcin\/bgg117","volume":"24","author":"EMJ der Logt Von","year":"2003","unstructured":"Von der Logt EMJ, Roelofs HMJ, Nagengast FM, Peters WHM (2003) Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. Carcinogenesis 24:1651\u20131656","journal-title":"Carcinogenesis"}],"container-title":["Cancer Chemotherapy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-010-1310-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00280-010-1310-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00280-010-1310-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T10:07:07Z","timestamp":1559038027000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00280-010-1310-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,31]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["1310"],"URL":"https:\/\/doi.org\/10.1007\/s00280-010-1310-4","relation":{},"ISSN":["0344-5704","1432-0843"],"issn-type":[{"value":"0344-5704","type":"print"},{"value":"1432-0843","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,31]]}}}